Man's physical universe

xanabras

C

H

C

II I

I

H

H—

H—

RELIEF OF PAIN REVOLUTIONIZED SURGERY 781

0=C—OCH2N(C2H5)2

C H H

C—

C

\ I

C— H— C—C=C—

\ / I

C H—

I \ /

/ \ II

I II /

o

I

C2H5

intracaine

nupercaine

c

H

O—N—CH2—CH2—N(C2H5)2

C—N=C—O—C4H9

Some of the newer substances used for injection are apothesin,

tutocaine, procaine borate, and intracaine. A comparison of the

formulas of procaine and intracaine will serve to show how the chemist

alters compounds in order to change their properties for special

purposes.

Intracaine is more effective, quicker, and less toxic than procaine.

Nupercaine is another local anaesthetic that is characterized by

its high degree of efificiency in great dilution and in its duration of

action. You may be interested in comparing the formulas of procaine

and intracaine with that of nupercaine.

There is another class of local anaesthetics which, owing to their

insolubility in water, must be applied in the form of dusting powders

or ointments. One of the best of these anaesthetics which are used for

direct application (and therefore called topical anaesthetics) is butesin.

Butesin is nontoxic and nonhabit-forming. Butesin will combine with

the antiseptic, picric acid, to yield butesin picrate, which possesses

antiseptic as well as anaesthetic properties and is therefore used in

ointments for burns in spite of the fact that some people are very

sensitive to butesin picrate; it should not be used indiscriminately.

Many of the commonly used local anaesthetics have produced fatal

accidents due to improper dosage, idiosyncrasies, and other conditions.

A study of the structural formulas for cocaine, j8-eucaine, and

procaine would show the organic chemist that certain organic groups

must be present to produce local-anaesthetic properties. On the other

hand, the presence of certain other groups may have no physiological

value, but it may mean a considerable saving in manufacturing costs.

Hjrpnotics Are Useful in the Treatment of Insomnia.

Hypnotics resemble narcotics and anaesthetics in that they produce

sleep, but hypnotics generally do not stop pain. When there is a need

More magazines by this user
Similar magazines