Man's physical universe

xanabras

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784 MAN'S PHYSICAL WELFARE

Inasmuch as hypnotics (sedatives) are habit-forming and poison

the body, they should be used only in time of real need and then only

under the observation of a competent physician.

Analgesics Give Relief from Pain.

Antipyretics are drugs which reduce the bodily temperature, particularly

when one has a fever.

All known antipyretics act, to some extent,

as analgesics. An analgesic is a pain-reliever. Nearly all of the antipyretics

are aromatic compounds.

Quinine is an effective antipyretic, but its former high price caused

the search for other substances such as the acetanilide and salicylic

acid derivatives.

It has been shown that the antipyretic action of the above compounds

resides in the benzene ring, yet benzene itself, CeHe, is not an

antipyretic; one of the hydrogen atoms must be substituted by radicals

to enable the CeHe ring to react with the bodily cells.

The continued use of acetanilide ("headache powders") has occasionally

caused the development of a drug habit and often does serious

damage because of its toxicity.

Antipyretics must be given in

larger doses to produce antipyretic

action than are required to produce analgesic action. Undesirable

effects frequently accompany the use of antipyretics; therefore they

should never be used except under the guidance of a competent

physician.

Sodium salicylate is an effective antipyretic and analgesic that is

used in the treatment of articular rheumatism. The desire to avoid

the disagreeable taste and undesirable effects of sodium salicylate led

to the introduction of such derivatives as aspirin and salol.

is noted for its analgesic properties.

Aspirin

Salicylates are probably safer to use than the derivatives of acetanilide,

when employed in small doses as analgesics.

H—

H—

OH OCOCH3 OH

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C—COONa H— C—COOH H— C—COOCeHa

C— H— C— H— C—

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c c c

sodium salicylate acetylsalicylic acid phenyl salicylate

(aspirin)

(salol)