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Email: firstname.lastname@example.org Whatsapp:+8618928439036 intention to treat. This study is registered with ClinicalTrials.gov, number NCT00263042. (3) Findings At a mean follow-up of 13·8 months (95% CI 13·6–14·0), the trial was prematurely discontinued because of concerns by health regulatory authorities in three countries about suicide in individuals receiving rimonabant. All randomised participants were analysed. At the close of the trial (Nov 6, 2008), the composite primary endpoint of cardiovascular death, myocardial infarction, or stroke occurred in 364 (3·9%) patients assigned to rimonabant and 375 (4·0%) assigned to placebo (hazard ratio 0·97, 95% CI 0·84–1·12, p=0·68). With rimonabant, gastrointestinal (3038 [33%] vs 2084 [22%]), neuropsychiatric (3028 [32%] vs 1989 [21%]), and serious psychiatric side-effects (232 [2·5%] vs 120 [1·3%]) were significantly increased compared with placebo. Four patients in the rimonabant group and one in the placebo group committed suicide. (4) Interpretation The premature termination of this trial has important lessons for drug development. A drug that was being marketed for weight loss, but being tested for improving cardiovascular outcomes, induced a level of serious neuropsychiatric effects that was deemed unacceptable by regulatory authorities, and both the drug and the trial were abruptly terminated. Also Checkout: rimonabant fda,rimonabant china, rimonabant cb1, rimonabant drug, rimonabant production, rimonabant reddit,rimonabant clinical trials.rimonabant buy,rimonabant weight loss. 18. Buy Rimonabant Powder online 14
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