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Email: firstname.lastname@example.org Whatsapp:+8618928439036 neurons controlling food intake is present. Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus.Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetiteIn therapeutic doses lorcaserin acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin also acts on 5-HT 2B and 5-HT 2A receptors. (2) Lorcaserin hydrochloride • Pharmacokinetics: Lorcaserin hydrochloride is rapidly absorbed in gastrointestinal tract and is delayed with fatty meals. Peak plasma concentration is achieved in 1.5-2 h, with half-life of 11h. It is evenly distributed in cerebrospinal fluid and central nervous system. Lorcaserin hydrochloride is 70% plasma protein bound and metabolized in liver, with major metabolite being lorcaserin hydrochloride sulfamate, and its excretion is mainly through urine (92%) and minor excretion through faces. (3) Lorcaserin hydrochloride works on Obesity The lorcaserin hydrochloride works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Serotonin is also involved in mood; many antidepressant drugs work by preventing the reuptake of serotonin and keeping brain receptors bathed in the chemical. Researchers at Arena say their drug is designed to seek out only the serotonin receptors that affect appetite. 4
Email: email@example.com Whatsapp:+8618928439036 6. How should Lorcaserin hydrochloride be used? Lorcaserin hydrochloride comes as a tablet to take by mouth. It is usually taken with or without food twice a day. Take lorcaserin hydrochloride at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lorcaserin hydrochloride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Lorcaserin hydrochloride may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.If you do not lose a certain amount of weight during the first 12 weeks of your treatment, it is not likely that you will benefit from taking lorcaserin hydrochloride. Your doctor may tell you to stop taking lorcaserin hydrochloride if you do not lose enough weight during the first 12 weeks of your treatment. Lorcaserin hydrochloride will help control your weight only if you continue to take it. Do not stop taking lorcaserin hydrochloride without talking to your doctor.Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. 5