Cu_Zn_Organometallics

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Preparations Homocuprate reagents (Gilman reagent: R 2 CuLi, R 2 CuMgX) • widely used organocopper reagents. • prepared by reaction of copper(I) bromide or preferably copper(I) iodide with 2 equivalents of appropriate lithium or Grignard reagents in ether or THF • The initially formed (RCu) n are polymeric and insoluble in Et 2 O and THF but dissolve on addition of a second equivalent of RLi or RMgX. • The resultant organocuprates are thermally labile and thus are prepared at low temperatures.
Preparations Heterocuprate reagents • Since only one of the organic groups of homocuprates is usually utilized, a non-transferable group bonded to copper, such as RC≡C, 2-thienyl, PhS, t-BuO, R 2 N, Ph 2 P, or Me 3 SiCH 2 , is employed for the preparation of heterocuprate reagents. • These cuprates are usually thermally more stable (less prone toward β-elimination of Cu–H), and a smaller excess of the reagent may be used.
Page 1 and 2: Organometallic Chemistry Worawan Bh
Page 3 and 4: Organocopper Reagents (Gilman Reage
Page 5: Organocopper compounds • Use of o
Page 9 and 10: Preparations Grignard-Copper(I) rea
Page 11 and 12: Reaction of Organocuprates Substitu
Page 13 and 14: Reaction of Organocuprates Substitu
Page 15 and 16: Reaction of Organocuprates Reaction
Page 17 and 18: Reaction of Organocuprates Epoxide
Page 19 and 20: Reaction of Organocuprates Epoxide
Page 21 and 22: Reaction of Organocuprates Conjugat
Page 23 and 24: Reaction of Organocuprates Conjugat
Page 25 and 26: Reaction of Organocuprates • The
Page 27 and 28: Reaction of Organocuprates • Reac
Page 29 and 30: Reaction of Organocuprates • Conj
Page 31 and 32: Reaction of Organocuprates Tandem 1
Page 33 and 34: Reaction of Organocuprates O-Trappi
Page 35 and 36: Reaction of Organocuprates Stereoch
Page 37 and 38: Reaction of Organocuprates Stereoch
Page 39 and 40: Organozinc reagents • The first o
Page 41 and 42: Preparations Alkylzinc iodides (RZn
Page 43 and 44: Preparations Dialkylzinc (R 2 Zn)
Page 45 and 46: Reaction of Organozinc compounds T
Page 47 and 48: Reaction of Organozinc compounds T
Page 49 and 50: Reaction of Organozinc compounds R
Page 51 and 52: Reaction of Organozinc compounds C
Page 53 and 54: Reaction of Organozinc compounds s
Page 55 and 56: Reaction of Organozinc compounds C
Page 57 and 58:
Reaction of Organozinc compounds T
Page 59 and 60:
References - organometallics • Co
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Cu_Zn_Organometallics

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