7 months ago

Coyne Healthcare - Bio-Curcumin

Notable Published

Notable Published Studies Completed on BCM-95 and AKBAMAX as of January 2018 A randomized, pilot study to assess the efficacy and safety of Curcumin in patients with active rheumatoid arthritis, Chandran B et al., Phytother Res, 2012;26(11):1719-25. A pilot clinical trial of radioprotective effects of Curcumin supplementation in patients with prostate cancer, Hejazi J et al., J Cancer Sci Ther, 2013;5:320-324. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis, Kizhakkedath R, Mol Med Rep, 2013;8(5):1542-8. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial, Sanmukhani J et al., Phytother Res, 2014:28(4):579-85. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Lopresti AL et al., J Affect Disord, 2014;167:368-75. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT, Buhrmann C et al., PLoS ONE 9(9): e107514. Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures, Shakibaei M et al., PLoS ONE 9(1): e85397. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer, Shakibaei M et al., BMC Cancer, 2015;15:250. Novel evidence for Curcumin and boswellic acid-induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer, Toden S et al., Cancer Prev Res (Phila), 2015;8(5):431-43. Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. Lopresti AL et al., Eu Neuropsychopharmacol, 2015;25(1):38-50. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer, Toden S et al., Carcinogenesis, 2015;36(3):355-67. BCM-95 and (2-hydroxypropyl)-ß-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts, Tatti M et al., Hum Mol Genet, 2015;24(15):4198-211. Evaluation of antidepressant like activity of Curcumin and its combination with Fluoxetine and Imipramine: an acute and chronic study, Sanmukhani J et al., Acta Pol Pharm, 2011;68(5):769-75. Comparative study of the efficacy of Curcumin and Turmeric oil as chemopreventive agents in oral submucous fibrosis: a clinical and histopathological evaluation, J Deepa Das A et al., Indian Acad Oral Med Radiol, 2010;22(2):88-92. A pilot cross-over study to evaluate human oral bioavailability of BCM-95 ® CG, a novel bioenhanced preparation of Curcumin, Antony B et al., Indian J Pharm Sci 2008;70(4):445-449. Six-month double-blind, placebo-controlled, pilot clinical trial of curcumin in patients with Alzheimer’s disease, Baum L et al., J Clin Psychopharmacol, 2008:28:110-113. Curcumin effects on blood lipid profile in a 6-month human study, Baum L et al., Pharmaco Res, 56 (2007) 2007;56(6):509-514.

Bioavailability of Biocurcumax TM (BCM-095TM), Benny M et al., Spice India, 2006 (Sept);11-15. Enhancing the absorption of curcuminoids, Benny M et al., Spice India, 2005(July); 23-26. Evaluation of antiepileptic and memory retention activity of Curcumin per se and in combination with antiepileptic drugs, Anovadiya AP et al., Asian J Pharm Clin Res, 2014;6(2):145-148. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer, Toden S et al., Carcinogenesis, 2015:36(3):355-367. Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty) compared to Curcumin in Wistar rats, Vinaykumar S et al., Pharmacognosy Journal, 2016;8(4):380-384. Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: a bioavailable turmeric formulation, Aggarwal ML et al., Mol Med Rep, 2016;13:592-604. Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults, Rainey-Smith SR et al., 2016;115(12):2106-2113. Effect of Curcumin supplementation during radiotherapy on oxidative status of patients with prostate cancer: a double blinded, randomized, placebo-controlled study; Hejazi J et al., Cancer, 2016;68(1):77-85. A randomized double-blind placebo-controlled phase IIB trial of curcumin in oral leukoplakia, Kuriakose MA et al., Cancer Prev Res (Phila), 2016;9(8):683-691. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and biocurcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebocontrolled study, Sterzi S et al., Eur J Phys Rehabil Med, 2016:52(3):321-330. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a randomised, double-blind, placebo-controlled study, Lopresti AL et al., J Affect Disord, 2017; 207:188-196. Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Siddappa G et al., Molecular Carcinog, 2017;56:2446–2460. Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood, Journal of Translational Medicine 201715:213 Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis,Toden S et al., Sci Rep, 2017;7(1):814. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study, Haroyan A et al., BMC Complement Altern Med, 2018;18(1):7

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