7 months ago

Coyne Healthcare - Bio-Curcumin

Boswellia serrata

Boswellia serrata Boswellia (also commonly known as Frankincense) is a plant native to India and Pakistan, used extensively in traditional Ayurveda medicine and to a lesser degree Chinese traditional medicine. The gum resin is extracted from which one obtains the active boswellic acids. The major anti-inflammatory benefit arises from its novel inhibition of a pro-inflammatory enzyme called 5-Lipoxygenase (LOX) as well as it’s positive effect on NF-kB. Over and above the anti-inflammatory benefit, Boswellia has also been proven to have an effective analgesic effect and is well tolerated with a strong long term safety profile. This makes it an excellent consideration for those challenged with chronic conditions resulting in pain and inflammation. There are two major points of consideration when wanting to utilise boswellic acids therapeutically. 3-Acetyl-11-keto-beta-boswellic acid = 3-Acetyl-11-keto-beta-boswellic acid - referred to as AKBA - has been clinically shown to be the most potent anti-inflammatory acid of boswellia, whereas β-boswellic acid has been shown to stimulate the platelet-induced generation of thrombin, liberate arachidonic acid, and induce platelet aggregation. It therefore makes sense to consider supplementation rich in AKBA which is free from β-boswellic acid for the purpose of reducing pain and inflammation. AKBA 3% - 10% - 30% Comparison of efficacy across concentrations 5-LOX activity 15-LOX activity 4 5 3 4 IC50 values in µM 2 1 IC50 values in µM 3 2 1 3% AKBA 10% AKBA 30% AKBA 0 0 3% AKBA 10% AKBA 30% AKBA Study of lipoxygenase inhibitory effect - In vitro study in human monocytes • 5-LOX and 15-LOX inhibited in a dose dependant manner • 3% vs 10%: significent inhibiton • 10% vs 30%: no further significant inhibition

AKBAMAX A high quality standardised extract of Boswellia serrata containing a rich supply of AKBA and no β-boswellic acid in a therapeutic and safe concentration. • Standardized with 10% AKBA • Enriched with acetyl group of boswellic acids • Does not contain β-boswellic acids • Total boswellic acids minimum 40% (HPLC) • Does not use strong acids for acetylation • Natural inhibitor of leukotrienes (LOX) • Clinically proven and produced under GMP BCM-95 & AKBAMAX Synergistic Effect of BCM- 95 & AKBAMAX Linoleic acid 18:2 present in most of vegetable oils gamma-linolenic acid ki/Gamma-Linolenic_acid Dihomo-gamma-lin olenic acid 20:3 28 Delta 5 desaturase Arachidonic acid 20:4 w6 Good PGE 1 Cycloxygenase 2 (COX 2) BCM-95 (INHIBITS) 5 Lipoxygease (AKBA INHIBITS) Most of the anti-arthritic drugs are COX 2 inhibitors COX 2 inhibitors do not block 5 Lipoxygenase pathway Prostaglandin E2 (PGE 2) Leukotriene B(4) Inflammation, pain and joint destruction

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