Hydralazine HCL(304-20-1): Work & Dosage & Side Effects | AASraw
Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. Visit: http://www.aasraw.com/products/hydralazine-hydrochloride-powder/
Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. Visit: http://www.aasraw.com/products/hydralazine-hydrochloride-powder/
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enhance the effects of nitrates and to mitigate the tolerance associated with<br />
chronic nitrate therapy. The antioxidant effect of hydralazine <strong>HCL</strong> can be<br />
attributed to its ability in inhibiting oxidase formation. The accumulation of<br />
oxidative free radicals creates an environment where chronic reductions in<br />
NO bioavailability contribute to a loss of skeletal muscle microvessels. This<br />
effect, in turn, leads to impaired muscle perfusion with elevated metabolic<br />
demand. Studies show that treatment with hydralazine <strong>HCL</strong> markedly inhibits<br />
oxidase which plays a role in regulating the bioactivity of NO, produced<br />
either endogenously or when administered exogenously.<br />
Cerebral, coronary, splanchnic, and renal blood flow usually increase<br />
following administration of hydralazine <strong>HCL</strong>, while urinary parameters are<br />
generally unaffected. hydralazine <strong>HCL</strong> increases renin activity in plasma,<br />
presumably by the renal juxtaglomerular cells in response to sympathetic<br />
nervous system stimulation; the increase in renin activity leads to the<br />
production of angiotensin II, which stimulates aldosterone and thus, sodium<br />
reabsorption. Due to fluid retention, plasma volume increases. As a result,<br />
tolerance can develop, which may account for the absence of improvement in<br />
some patients receiving the drug for prolonged periods of time.<br />
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