Cell Biology

nottingham.edu.my

Cell Biology

Cultured

Neuronal Network


Cultured

Neuronal Network

Virtual

Environment


Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

Cultured

Neuronal Network

Spike Stimulation

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Cell Biology

- Rat hippocampal cells

Glia, Neuroprogenitors)

Cultured

Neuronal Network

Spike Stimulation

- Microcultures (~100 cells)

S E N S O R Y I N P U T

- Characterisation (Neurons,

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

- Human stem cells?

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


- Temperature, O2/CO2,

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

pH, media

Cultured

supply

Neuronal Network

Spike Stimulation

- Constant physicochemical

environment

S E N S O R Y I N P U T

- Drug delivery (neuromodulators)

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- High-speed, adaptive,

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Optical Engineering

Cultured

compressive

Neuronal Network

sampling

Spike Stimulation

- Intelligent-camera development

- Custom CMOS sensor

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling


- Neuromodulation

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuropharmacology

- Rapid drug delivery

- Network-state control

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

(Reward /

Cultured

Punishment)

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling


- Experimental design

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Mathematics

- Network modelling

Cultured

Neuronal Network

Spike Stimulation

- Formalism & representation

- Rule-set design

- Neural computation

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

I(q)

Stimulation

R(q)

Q

Virtual

I(q)

Environment

view

q

view

Sensory Neurons N i

Bin i

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

q


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


- Virtual environment

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Computer Science

- System control (imaging,

- Real-time

Cultured

data analysis

Neuronal Network

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

stimulation, microfluidics)

and feedback

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Computer Science

- System control (imaging,

stimulation, microfluidics)

- Virtual environment

- Real-time data analysis

and feedback

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


- Spatial Light Modulator

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Optical Engineering

- Patterned Illumination

- LED light sources

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Computer Science

- System control (imaging,

stimulation, microfluidics)

- Virtual environment

- Real-time data analysis

and feedback

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Optical Engineering

- Patterned Illumination

- LED light sources

- Spatial Light Modulator

Computer Science

- System control (imaging,

stimulation, microfluidics)

- Virtual environment

- Real-time data analysis

and feedback

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


- Light sensitive ion channels (Rhodopsins)

S E N S O R Y I N P U T

- Lentiviral vector

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Molecular Biology

- Optogenetics

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Optical Engineering

- Patterned Illumination

- LED light sources

- Spatial Light Modulator

Computer Science

- System control (imaging,

stimulation, microfluidics)

- Virtual environment

- Real-time data analysis

and feedback

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q


Molecular Biology

- Optogenetics

- Light sensitive ion channels (Rhodopsins)

- Lentiviral vector

Surface Chemistry

- Analysis and modification

- Patterned cell adhesion

- Long term cell survival

Cell Biology

- Rat hippocampal cells

- Microcultures (~100 cells)

- Characterisation (Neurons,

Glia, Neuroprogenitors)

Microfluidics

- Constant physicochemical

environment

- Temperature, O2/CO2,

pH, media supply

- Drug delivery (neuromodulators)

Neuroelectronics

- Spike detection

- Multielectrode arrays

Neurophotonics

- Novel imaging technology

(Surface Plasmon

Resonance Imaging)

Cultured

Neuronal Network

Spike Stimulation

S E N S O R Y I N P U T

R E W A R D S I G N A L S

Neuromodulation

M O T O R O U T P U T

Spike Detection

Virtual

Environment

Optical Engineering

- Patterned Illumination

- LED light sources

- Spatial Light Modulator

Computer Science

- System control (imaging,

stimulation, microfluidics)

- Virtual environment

- Real-time data analysis

and feedback

Neuropharmacology

- Rapid drug delivery

- Network-state control

- Neuromodulation

(Reward / Punishment)

Optical Engineering

- Intelligent-camera development

- Custom CMOS sensor

- High-speed, adaptive,

compressive sampling

Mathematics

- Formalism & representation

- Rule-set design

- Experimental design I(q)

- Network modelling

- Neural computation

R(q)

Stimulation

I(q) q

Q

view

view

Sensory Neurons N i

Bin i

q

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