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NEW ZEALAND SEPTEMBER <strong>2018</strong><br />

Feature<br />

DRY EYE <strong>2018</strong><br />

The latest research<br />

Page 17<br />

Business<br />

Measuring practice<br />

intelligence<br />

Page 46<br />

Education<br />

Allergic to glasses?<br />

Page 52<br />

THE MAGAZINE FOR NEW ZEALAND’S OPHTHALMIC COMMUNITY<br />

PO Box 106 954, Auckland City 1143<br />

NEW<br />

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WWW.EYEONOPTICS.CO.NZ | 1<br />

13/8/18 12:53 pm


<strong>2018</strong> • Voted by Australians • <strong>2018</strong><br />

<strong>2018</strong> • Voted by New Zealanders • <strong>2018</strong><br />

Voted by New Zealanders<br />

ROLLOUT ALMOST COMPLETE!<br />

OCT IN EVERY<br />

PRACTICE<br />

EYE HEALTH IMPACTS, INVESTMENT UNDERWAY<br />

At Specsavers, our optometrists are at the forefront of improving detection, referral and diagnosis<br />

rates for eye disease and a range of eye conditions in both New Zealand and Australia.<br />

With the rollout of OCT technology into every practice now underway across<br />

New Zealand, linked to our patient management and electronic referral<br />

systems, our optometrists are already starting to make a marked difference<br />

to eye health outcomes. In one of the most ambitious screening programs<br />

ever undertaken, we are using OCT as a standard element of our pre-test<br />

routine, with every patient.<br />

Our aim? To give Specsavers optometrists access to the readings, data and<br />

3-D images that will enable them to deliver a new standard in eye health<br />

assessment and patient care.<br />

That’s why we’re making multi-million-dollar investments into technology,<br />

the latest equipment and professional development, while our optometry<br />

support team is developing ever closer working relationships with<br />

ophthalmology and eye disease stakeholders. And we continue to make<br />

parallel investments into dispensing qualifications and professional<br />

development.<br />

It all adds up to the fact that we’re on a clear mission to transform eye health<br />

in Australia and New Zealand – and we’d like you to join us on that mission.<br />

To find out more about optometry and dispensing roles across the country at all levels, contact Chris Rickard on<br />

027 579 5499 or email chris.rickard@specsavers.com. Alternatively, visit spectrum-anz.com for all the opportunities.<br />

Reader’s<br />

Digest<br />

Quality Service<br />

Award<br />

Reader’s<br />

Digest<br />

Quality Service<br />

Award<br />

AITD<br />

Reader’s Digest<br />

Quality Service<br />

Award<br />

2017<br />

Best<br />

Wellbeing<br />

Project<br />

<strong>2018</strong><br />

Best Customer<br />

Service in AU<br />

Optometry<br />

<strong>2018</strong><br />

Best Customer<br />

Service in NZ<br />

Optometry<br />

<strong>2018</strong><br />

Best Talent<br />

Development<br />

Program<br />

2017<br />

Best Talent<br />

Development<br />

Program<br />

2017<br />

Best Customer<br />

Service in NZ<br />

Optometry<br />

2017<br />

Millward Brown<br />

Research<br />

No.1 for eye tests<br />

2016<br />

Excellence in<br />

Marketing<br />

Award<br />

2016<br />

Retail<br />

Store Design<br />

Award<br />

2016<br />

Transforming eye health


4 EDITORIAL<br />

NEWS<br />

6 Empowering disabled choice<br />

15 Retinal surgery trends<br />

44 Personalising glaucoma<br />

48 EyeBall’s island of vision<br />

48<br />

DRY EYE <strong>2018</strong><br />

17 A year on from TFOS DEWS II<br />

30 Cataract surgery and dry eye<br />

34 Dry eye and autologous serum<br />

40 Setting up a dry eye clinic<br />

BUSINESS<br />

46 Measuring practice intelligence<br />

EDUCATION<br />

52 Allergic to glasses?<br />

53 A celebrity’s corneal erosion pain<br />

15<br />

26<br />

FASHION<br />

47 Jono: time for design<br />

50 News and warmth from the O-Show<br />

55 CLASSIFIEDS<br />

58 CHALKEYES PRESENTS<br />

6<br />

53<br />

www.eyeonoptics.co.nz | PO Box 106954, Auckland 1143 | New Zealand<br />

For general enquiries or classifieds please email info@nzoptics.co.nz<br />

For editorial, please contact Lesley Springall at lesley@nzoptics.co.nz or +64 27 445 3543, or Heather Douglas at heather@nzoptics.co.nz<br />

For all advertising/marketing enquiries, please contact Susanne Bradley at susanne@nzoptics.co.nz or +64 27 545 4357 in the first instance, or Lesley Springall at lesley@nzoptics.co.nz<br />

To submit artwork, or to query a graphic, please email susanne@nzoptics.co.nz<br />

NZ Optics magazine is the industry publication for New Zealand’s ophthalmic community. It is published monthly, 11 times a year, by New Zealand Optics 2015 Ltd. Copyright is held by NZ Optics 2015 Ltd.<br />

As well as the magazine and the website, NZ Optics publishes the annual New Zealand Optical Information Guide (OIG), a comprehensive listing guide that profiles the products and services of the industry.<br />

NZ Optics is an independent publication and has no affiliation with any organisations. The views expressed in this publication are not necessarily those of NZ Optics 2015 Ltd or the editorial team.


EDITORIAL<br />

Delving into dry eye, and more<br />

PHEW! THIS IS OUR BIGGEST issue ever, 60<br />

pages, and I couldn’t be more proud of it or our<br />

fourth and biggest Dry Eye <strong>2018</strong> special feature.<br />

There’s no denying that in the wake of the<br />

TFOS DEWS II report, dry eye has become<br />

big business and not just for those looking to<br />

profit, but among researchers who are finally<br />

receiving the funding they need to unravel<br />

the complexities of this too-long-ignored<br />

disease. We are lucky to have one of the<br />

world’s emerging gurus on all things dry eye,<br />

Associate Professor Jennifer Craig, based in<br />

New Zealand, leading and collaborating on<br />

much of the research tackling dry eye disease<br />

conundrums. Under Jen’s careful eye we have<br />

pulled together updates on much of this<br />

research (p17-43); shared insights into some<br />

big dry eye discussions - dry eye and cataract<br />

surgery (p30), allergies (p32) and autologous<br />

serum (p34); reviewed advances in eye drops<br />

(p37); and provided advice on setting up your<br />

own dry eye clinic (p40).<br />

To accommodate this very special annual<br />

feature we’ve had to move a lot of our news to<br />

online, so do check out www.eyeonoptics.co.nz<br />

when you can. That said, we’ve still got plenty of<br />

non-dry eye news in this month’s issue, including<br />

the latest funding changes for the country’s low<br />

vision population (p6); international retinal<br />

surgery trends (p15); and the big drawcards at<br />

the <strong>2018</strong> OSO and RANZCO conferences (p44<br />

and p47).<br />

We review what happened at this year’s<br />

O-Show (p50) and Silmo Sydney (p54) and<br />

feature the glamorous outfits from this year’s<br />

EyeBall (p48). Plus, don’t miss this month’s<br />

Stars and their Eyes which reviews Fox News<br />

queen Shannon Bream’s nightmare corneal<br />

erosion misdiagnosis, and the appalling<br />

attitude of her first ophthalmologist (p53); Style<br />

Eyes, which tackles patients’ spec allergies; and<br />

Chalkeyes presents, which fuels our imagination<br />

with a bit of shark waving.<br />

Enjoy!<br />

Lesley Springall, editor,<br />

NZ Optics<br />

CONTRIBUTORS<br />

Associate Professor Jennifer Craig<br />

It’s hard to imagine anyone who is anyone<br />

within dry eye research today who has not<br />

heard of our own dry eye specialist, Associate<br />

Professor Jennifer Craig. Vice chair of the<br />

hugely influential Tear Film & Ocular Surface<br />

Society’s second international dry eye<br />

workshop (TFOS DEWS II), Jen has travelled<br />

the world discussing the workshop’s findings;<br />

something she describes as “a privilege” given<br />

it’s in a field where the unmet need is so great.<br />

“If we persevere in our quest to seek answers and learn more through<br />

our research, we might be able to make a real difference to the quality<br />

of life of our patients.” Given the rise in interest and funds for dry eye,<br />

she says she’s hopeful we might see similar advances within the next<br />

decade to those we’ve seen over the last 25 years.<br />

Of all the places she’s visited, one stand-out was Transylvania and<br />

the obligatory visit to ‘Dracula’s castle’, she says. Peru also sparked<br />

her interest in exploring Latin America and perhaps visiting the real<br />

Machu Picchu (see p17) next time she’s there.<br />

When not spreading the dry eye-word internationally or focusing on<br />

her own or her growing team’s research into dry eye, her family keeps<br />

her busy, she says. “With two teenage sons and an ophthalmologist<br />

husband who all live life to the full, there’s always plenty going on.<br />

We all get a lot of enjoyment from music, jamming together and<br />

contributing to various bands as musicians, or in my case as a ceilidh<br />

dance caller and demonstrator. I love to dance when I get the chance<br />

and aspire to becoming a better fiddle (violin) player.”<br />

Jen is the hard-working clinical editor on our very special, annual dry<br />

eye feature (p17-43).<br />

4 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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WWW.EYEONOPTICS.CO.NZ | 5


NEWS<br />

Empowering disabled choice<br />

By Heather Douglas<br />

A NEW DISABILITY support system, including<br />

a new funding model, will be trialled from 1<br />

October in the MidCentral District Health Board<br />

(DHB).<br />

The new Enabling Good Lives (EGL) initiative<br />

shifts the decision-making power to the<br />

disabled person to make choices about what<br />

works best for them and includes a personal<br />

budget, moving the funding model away from<br />

government-contracted services, to allow each<br />

disabled person to buy the services they need.<br />

While personal budgets have been around<br />

for several years, the key difference with<br />

the MidCentral roll-out is that anyone who<br />

currently receives funding from the Ministry of<br />

Health or Ministry of Social Development will<br />

automatically qualify for a personal budget,<br />

said Dr Garth Bennie, CEO of the New Zealand<br />

Disability Support Network (NZDSN). This<br />

personal budget is also more flexible than either<br />

the individualised funding (IF) scheme or the<br />

enhanced individualised funding (EIF) scheme<br />

currently offered in some regions, he says. The new<br />

MidCentral initiative “is about disabled people and<br />

their whānau having more options and greater<br />

decision making over what supports they need<br />

to live the life they want, rather than their lives<br />

having to fit around what has been on offer,”<br />

explains disability issues minister Carmel <strong>Sep</strong>uloni.<br />

In the longer term, the new funding model<br />

could lead to major changes for governmentfunded<br />

disability organisations, says Dr Bennie,<br />

noting that communities are looking forward<br />

to the coming changes while providers are<br />

variously enthusiastic, tentative, nervous and<br />

terrified by them.<br />

Feedback from disabled<br />

people… has been<br />

overwhelmingly positive,<br />

with most feeling<br />

significantly more<br />

independent”<br />

What it means for low vision patients<br />

“We have a contract with the Ministry of Health<br />

to deliver New Zealand vision rehabilitation<br />

services… That’s not up for challenge at the<br />

moment,” says Blind Foundation policy manager<br />

Dianne Rogers, but this initiative will still mean<br />

the Foundation has to offer the best services it<br />

can to what is essentially a new market where<br />

people get to choose the services they need.<br />

It is a big challenge, she concedes, but the<br />

changes won’t affect everyone, mostly just the<br />

younger market. “So, we want to make sure<br />

that we’re agile, we’re flexible, we’re thinking<br />

about what their needs are. We’re looking at our<br />

infrastructure and systems, making sure that<br />

people will want to engage with them on a oneon-one<br />

basis.”<br />

Australia’s model<br />

Across the Tasman, disability support providers<br />

have faced a shake-up with the introduction<br />

of Australia’s National Disability Insurance<br />

Scheme (NDIS), which is being rolled out<br />

nationwide over three years (2016-9). Although<br />

there are significant differences, it, too, aims<br />

to give people with disability better access to<br />

personalised support services. Vision Australia<br />

NDIS programme manager Scott Jacobs says the<br />

shift has been exceptionally positive, but warns<br />

the change can be challenging for support<br />

organisations. “The NDIS funds more services,<br />

to more people, in the blindness and low vision<br />

community than ever before. The biggest shift<br />

has been changing the relationship dynamic<br />

between clients and the organisation… Don’t<br />

underestimate the burden of change. Everything<br />

from administration and service agreements<br />

through to billing and financials will be different,<br />

and it requires methodical planning.”<br />

Jason Abrahams, Australasian general<br />

manager of Humanware, a manufacturer and<br />

supplier of low vision and blindness-assistive<br />

technologies, agrees the change to NDIS has<br />

been hugely disruptive. In hindsight, he says,<br />

he would have worked quicker to arm his team,<br />

his advocates and his clients with literature<br />

to help them with funding submissions.<br />

Providing simple ‘Why fund me?’ sheets and<br />

website content alongside product and service<br />

information would have avoided many lengthy<br />

funding refusals.<br />

But with most teething problems now ironed<br />

out, overall the change has been positive, he says.<br />

Returning to New Zealand<br />

There would be no overnight avalanche of<br />

applications in New Zealand, stressed Dr Bennie.<br />

While NZDSN supported the direction of<br />

change, questions still needed answering, such<br />

as, who’s doing the maths? “We are engaged<br />

right now in some very difficult conversations<br />

with government around appropriate levels of<br />

funding, which has been exacerbated by the<br />

recent pay settlement.”<br />

Feedback from disabled people who have<br />

had more say in shaping their support has been<br />

overwhelmingly positive, however, with most<br />

feeling significantly more independent, while<br />

many families say they feel their burden has<br />

been eased.<br />

The MidCentral initiative will be implemented<br />

on a ‘try, learn and adjust’ approach in the first<br />

year with changes expected following feedback<br />

from disabled people using the scheme, their<br />

whānau and others in the disability sector. No<br />

decisions have been made about expanding the<br />

new support system beyond MidCentral region,<br />

but ministers will be provided with advice on<br />

this in late 2020, said MoH spokesperson Emily<br />

Barrett. <br />

For the longer version of this story, please visit<br />

www.eyeonoptics.co.nz<br />

More news? See<br />

online…<br />

• How blue light speeds blindness<br />

• Amniotic membrane for dry eye?<br />

• Ethnicity and trabeculectomy outcomes<br />

• Cold as ocular anaesthetic alternative<br />

For more news, more international<br />

stories and all your favourite stories and<br />

columns from NZ Optics,<br />

visit www.eyeonoptics.co.nz<br />

6 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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on their treatment<br />

post-consultation<br />

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Find out more at myhealth1st.co.nz<br />

or by calling 0800 424 303


NEWS<br />

New smartphone<br />

ophthalmoscope<br />

oDocs Eye Care is set to release the<br />

oDocs nun, a portable smartphone<br />

ophthalmoscope, capable of both<br />

mydriatic and non-mydriatic retinal<br />

imaging. The device can be used<br />

independently as a handheld<br />

ophthalmoscope or with a broad<br />

range of smartphone gadgets<br />

running on the iOS and Android<br />

platforms.<br />

“The direct ophthalmoscope was<br />

invented 160 years ago. The optics<br />

remain the same. No wonder many<br />

physicians struggle with it,” said the company’s founder Dr Sheng Chiong<br />

Hong. “It is time for a complete upgrade.”<br />

The ODocs nun has already achieved the CE Mark as a Class 1 medical<br />

device and is registered with MedSafe and the Therapeutic Goods<br />

Administration (TGA). Pre-orders should be available from November,<br />

ahead of the official launch planned for the first quarter of 2019. Customers<br />

who pre-order the device will save up to $170 and receive it before the end<br />

of this year, said Dr Hong.<br />

oDocs Eye Care is a New Zealand social enterprise which designs and<br />

manufactures professional, portable eye care adaptors that can be used by<br />

anyone with a smartphone. Its mission is to end preventable blindness by<br />

ensuring professional eye care is accessible to anyone who needs it. <br />

For more information see ad on p47.<br />

<strong>2018</strong> Spring Update<br />

Retina Specialists invites you to an educational evening<br />

(This event has been accredited by NZAO for 1.75 CPD points)<br />

Speakers<br />

Dr Rachel Barnes<br />

Interpreting OCTs: tips, tricks and pitfalls to avoid<br />

Dr Andrea Vincent<br />

Stem cells in eye disease treatment - myths, risks and reality<br />

Dr Narme Deva<br />

Myopic maculopathy<br />

Dr Peter Hadden<br />

Retinal Detachment and its differential diagnosis<br />

When: Tuesday 4 th <strong>Sep</strong>tember – 6pm to 8.30pm or<br />

Tuesday 18 th <strong>Sep</strong>tember – 6pm to 8.30pm<br />

Where: Retina Specialists,1 st Floor, 20 Titoki Street, Parnell<br />

Nibbles and drinks will be provided.<br />

RSVP to:<br />

09-307-2020 or email: practicemanager@retinaspecialists.co.nz<br />

by 3 rd <strong>Sep</strong>tember <strong>2018</strong>. Please state which event you would like<br />

to attend and provide NZAO No. and Board Registration.<br />

The Texas A&M University team and their NOVA cane prototype.<br />

White cane goes high-tech<br />

FOUR ENGINEERING STUDENTS at Texas A&M University have<br />

developed a white cane attachment that detects objects and helps the<br />

user navigate around them using an ultrasonic sensor and a variety of<br />

vibrations.<br />

Electronics systems engineering technology students Garrett<br />

Friedrichs, Hunter Schwedler, Brady Langston, Jason Belmares and Lathan<br />

Moore spent more than a year developing the Navigational and Object<br />

Visual Assistant (NOVA), which uses an ultrasonic sensor and vibration<br />

motors to alert white cane users of any obstacles above the waist with<br />

specific vibration patterns. The team also created a mobile application that<br />

interacts with NOVA to signal directions to the user (eg. turn left, turn<br />

right).<br />

“[NOVA] has no auditory feedback at all, which is a big thing that<br />

visually impaired students stressed they wanted,” said Schwedler. “They<br />

need to closely listen to their surroundings and any sort of unnecessary<br />

sound can be distracting.” <br />

AOA complains to Facebook<br />

THE AMERICAN OPTOMETRIC ASSOCIATION (AOA) has written to<br />

Facebook founder Mark Zuckerberg, asking the social media giant not<br />

to accept advertising from online eye test developer, Opternative.<br />

Fighting fire from the health industry, Opternative, which is finalising<br />

partnerships to enter New Zealand and Australia, is also the subject<br />

of enforcement action by the US Food and Drug Administration (FDA)<br />

for what the FDA said is a lack of review of the product’s safety and<br />

efficacy and premarket approval prior to marketing.<br />

“Given the serious nature of the FDA warning against Opternative,<br />

we wanted to ensure that you are aware that your platform is being<br />

used to advertise a company that has marketed its app-based vision<br />

test without clearance or approval required by the government, in<br />

violation of federal law,” AOA recent past president Christopher Quinn<br />

told Zuckerberg.<br />

Opternative claims its digital refractive test can be used by its<br />

partners to offer vision tests and acuity screenings, anywhere at any<br />

time and said it is working with the FDA to comply with regulatory<br />

requirements.<br />

The Facebook letter is the latest weapon employed by the AOA<br />

against Opternative, which has previously raised questions about<br />

the Opternative product’s safety and efficacy and concerns about<br />

inaccurate prescriptions and the inability of the product to diagnose<br />

more serious health conditions.<br />

Credit: Taylor Phillips-Rodriguez<br />

8 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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NEWS<br />

1st Group eyes ophthalmology<br />

AFTER TAKING THE Australasian optometry<br />

market by storm, 1st Group, the parent company<br />

of online booking and patient referral software<br />

platform MyHealth1st, is branching into<br />

ophthalmology.<br />

Just a week after announcing it had signed<br />

25% of New Zealand’s optometry practices in<br />

a few months*, the Australian Stock Exchange<br />

(ASX)-listed company issued another ASX<br />

announcement to say it had signed Vision Eye<br />

Institute (VEI) to its online patient engagement<br />

platform. With 16 sites across Victoria, New South<br />

Wales and Queensland, VEI is one of the biggest<br />

ophthalmology service providers in Australia.<br />

“This is an important strategic extension of our<br />

dominant market presence in the optometry<br />

market, where MyHealth1st will become<br />

increasingly involved in assisting the referral<br />

process to the ophthalmology sector by<br />

simplifying the experience for patients,” said<br />

Klaus Bartosch, 1st Group’s managing director in<br />

the ASX announcement.<br />

“Our collaboration with 1st Group will streamline<br />

the appointment making process and give us<br />

the opportunity to obtain real time feedback<br />

from our patients,” said James Thiedeman, VEI<br />

managing director.<br />

Promoting its role as patient booking and<br />

contact facilitator between optometry and<br />

ophthalmology, 1st Group can also operate<br />

with Oculo, the cloud-based secure messaging<br />

and clinical communication software company<br />

formed specifically to improve communication<br />

between optometry and ophthalmology,<br />

Bartosch told NZ Optics.<br />

“Ophthalmology patient referral processes are<br />

changing. Oculo now enables the clinical referral<br />

to be seamlessly transferred electronically, but<br />

the patient who had conveniently and easily<br />

booked their appointment online with their<br />

optometrist through MyHealth1st, is now<br />

Klaus Bartosch<br />

back to the dark ages, having to pick up the<br />

telephone to make their appointment to see the<br />

ophthalmologist. Over 65% of consumers find<br />

that process frustrating and inconvenient and<br />

many simply don’t bother at all or worse, wait<br />

until their condition worsens.”<br />

With 65% of the Australian independent<br />

optometry market along with 25% of the New<br />

Zealand market now using the MyHealth1st<br />

platform, Bartosch said it made sense to<br />

add ophthalmology to the mix, bringing the<br />

ophthalmic industry in-line with just about every<br />

other industry globally.<br />

“Patients increasingly prefer digital channels<br />

when accessing their healthcare services. I<br />

predict it won’t be long before all referrals<br />

between optometrists, GP’s and other referrers<br />

to specialists are conveniently handled through<br />

MyHealth1st, improving the connection<br />

between patient and their chosen healthcare<br />

service providers and complementing clinical<br />

referral systems like Oculo.” <br />

*www.eyeonoptics.co.nz/articles/archive/kiwipractices-embrace-online-booking/<br />

Kat Rollings Photography<br />

Negating<br />

poor practise<br />

RANZCO IS DEVELOPING a process<br />

to provide active assurance of safe<br />

practise across the region to safeguard<br />

the public from poorly performing or<br />

incompetent doctors. While the number<br />

of practitioners not performing up<br />

to standard was small, they are overrepresented<br />

in complaints and reflect<br />

poorly on the rest of the profession, said<br />

RANZCO president Associate Professor<br />

Mark Daniell in his address in RANZCO’s<br />

Eye2Eye magazine.<br />

Two of the biggest risk factors for<br />

under-performance are increasing age<br />

and professional isolation. RANZCO’s<br />

process will closely align to the Medical<br />

Board of Australia’s (MBA’s) five pillars<br />

of professional performance and will<br />

build on structures RANZCO already<br />

has in place, said A/Prof Daniell,<br />

including strengthened assessment<br />

of practitioners with multiple<br />

substantiated complaints against them<br />

and a formal peer review. It is also likely<br />

peer reviews and health checks will be<br />

required for doctors aged 70 and every<br />

three years after that.<br />

Details of this process are being<br />

finalised in conjunction with the MBA<br />

and the Australian Health Practitioner<br />

Registration Agency (AHPRA), and<br />

the College will have a key role in<br />

supporting those with performance<br />

issues so they are carefully rehabilitated<br />

back into safe practise and assisted with<br />

remediation strategies, said RANZCO.<br />

Assistant Professor Amy Schefler<br />

Targeted therapy for eye cancer?<br />

LIGHT-ACTIVATED AU-011 has the potential<br />

to be the first targeted therapy for the primary<br />

treatment of ocular melanoma, said Clinical<br />

Assistant Professor Amy Schefler from New<br />

York’s Weill Cornell Medicine, at the 36th<br />

American Society of Retina Specialists meeting<br />

in Vancouver, Canada.<br />

Dr Schefler presented data from an openlabel<br />

phase 1b/2 study on 30 adult subjects with<br />

clinically diagnosed small to medium primary<br />

choroidal melanoma. Early efficacy results<br />

continue to be promising, with several subjects<br />

in the multiple-ascending-dose cohorts showing<br />

evidence of reduction in tumour height and<br />

100% of patients meeting the endpoint of stable<br />

disease at three months, she said.<br />

No targeted therapies are available at<br />

present and current radiotherapy treatments<br />

can be associated with severe visual loss and<br />

other long-term sequelae such as dry eye,<br />

glaucoma, cataracts and radiation retinopathy,<br />

said Dr Schefler, who is an investigator for<br />

Aura Biosciences, which developed the new<br />

treatment.<br />

AU-011 therapy consists of patented viral<br />

capsid conjugates (VCC) with IR-700DX dye<br />

molecules that are activated with an ophthalmic<br />

laser, which causes the drug to disrupt the cell<br />

membrane of tumour cells while sparing key<br />

eye structures. AU-011 has been granted orphan<br />

drug and fast track designations by the US Food<br />

and Drug Administration. <br />

10 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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WWW.EYEONOPTICS.CO.NZ | 11


NEWS<br />

Pierre Longerna:<br />

optometry’s opportunities<br />

Essilor ANZ’s new French-born chief operating officer,<br />

Pierre Longerna, is optimistic about independent<br />

optometry’s future. Lesley Springall asked him about that<br />

future and ‘that merger’.<br />

Essilor New Zealand’s revenue held up well<br />

compared to Australia’s after the Luxottica<br />

merger announcement. Why was that?<br />

The combination of Essilor and Luxottica has<br />

raised a lot of questions for a lot of people. What<br />

the New Zealand team has done very well is to<br />

stay close to our customers, showing them that<br />

things are not going to change. Essilor is going<br />

to remain Essilor and Luxottica is going to remain<br />

Luxottica. In Australia, the situation was a little<br />

different because the team has not been as<br />

stable as in New Zealand. We had some gaps in<br />

the team at the wrong time, when our customers<br />

had a lot of questions. But it’s a combination<br />

of many factors in Australia that we’re now<br />

addressing.<br />

So, are Essilor ANZ’s closest customers not<br />

worried about the Luxottica merger?<br />

No, they are. Everywhere<br />

people are wondering<br />

what’s it about and that’s<br />

very fair. Most of our<br />

clients are independent<br />

and most are small, and<br />

they are dealing with a<br />

big company. So, they are<br />

looking at Essilor and are<br />

saying, ‘Now you are going<br />

to be part of something<br />

that’s even bigger. Am I<br />

going to be relevant to<br />

you? Are you going to<br />

continue to support me?’<br />

And that’s a fair concern<br />

because, for them, bigger<br />

doesn’t mean better.<br />

It’s our job is to explain that Essilor is not going<br />

to leave them; Essilor is just going to be stronger.<br />

We are going to be the same Essilor, it’s just that<br />

in our group there will be more assets, there will<br />

be more expertise, and we will find ways to use<br />

that expertise to give them additional services,<br />

additional solutions to continue to grow their<br />

business.<br />

What about concerns about competing<br />

against Luxottica’s OPSM chain?<br />

Again, our customer base is the same as it was<br />

yesterday, mainly independent optometrists.<br />

Our job is to continue to grow that segment of<br />

the market. But there are different segments in<br />

the market. OPSM focuses on Luxottica frames.<br />

It’s about fashion. Whereas an independent<br />

optometrist is all about vision care. So, when we<br />

introduce something like (our new progressive<br />

lens) the new Varilux X<br />

lens, that goes to the<br />

independent segment;<br />

those who have the<br />

training to understand and<br />

sell the lens. And that will<br />

remain the case tomorrow;<br />

it won’t go to OPSM.<br />

What are the key issues<br />

facing independent<br />

optometry today?<br />

Many people are<br />

pessimistic, they talk<br />

about fierce competition<br />

and difficulties in the<br />

industry and so on. But<br />

we are in a good industry.<br />

The industry is growing and there are drivers for<br />

that - the population is growing, the population<br />

is aging, we are introducing new solutions for<br />

their needs.<br />

We are also in an industry where people are<br />

used to good products, premium products so<br />

there are opportunities. There are plenty of<br />

people who need eyeglasses, but they only have<br />

one pair of eyeglasses, they don’t even have<br />

prescription sunglasses.<br />

Yes, there are new players in the market -<br />

Specsavers, Bailey Nelson, George & Matilda -<br />

they are investing into the market because they<br />

understand there is a lot of potential. But… you<br />

have different segments in the market. You have<br />

businesses whose first criteria is price; you have<br />

people where it’s all about fashion; then the final<br />

segment is about vision.<br />

The main challenge for optometrists is to be<br />

clear about where they are going to compete<br />

and how they are going to make a difference.<br />

For independent optometrists, it’s about leading<br />

the vision care segment. They also have to keep<br />

investing; investing in their business, investing in<br />

their customers, investing in what makes them<br />

different if they want to grow. If we stop investing<br />

in research and development (R&D), what can<br />

we expect? To continue to sell the same thing at<br />

the same price? No. It will become a price war.<br />

So, we are investing in R&D, we are investing in<br />

our customers, we are investing in training, in<br />

marketing, that’s the way to continue to grow the<br />

business and it’s the same for our customers. <br />

For the full interview go to www.eyeonoptics.co.nz<br />

EVF update<br />

NEARLY HALF OF the students screened<br />

for undiagnosed eye conditions in one<br />

Manawatu school were referred for further<br />

treatment, while 31% of all students across<br />

the five schools screened were referred, reveal<br />

the latest results from the Essilor Vision<br />

Foundation screening programme.<br />

To date, about 4000 Kiwi children have<br />

been screened by the charity since launching<br />

its screening initiative in New Zealand more<br />

than two years ago, with almost a third found to<br />

have a range of eyesight conditions. Manawatu,<br />

Taranaki and Wanganui are the most recent<br />

regions to be screened, with South Auckland<br />

next in line.<br />

Helping in the Manawatu region were<br />

volunteers from Visique Eye Spy and Visique<br />

Naylor Palmer. “The work of the charity has<br />

made a real difference in the lives of thousands<br />

of these low decile school children who were<br />

living with undiagnosed vision conditions,” said<br />

Eye Spy optometrist Maile Tarsau (pictured).<br />

12 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


NEWS<br />

The Gordon Sanderson Award<br />

Richard Grills<br />

NEW<br />

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She wears Sensity Shine,<br />

Light Copper Mirror Brown<br />

RICHARD GRILLS, THE founder<br />

of Designs for Vision, well-known<br />

optometry and ophthalmology<br />

educator and long-time friend<br />

of Associate Professor Gordon<br />

Sanderson who died last year, has<br />

been named the inaugural winner<br />

of a new award named in honour<br />

of his friend.<br />

The Gordon Sanderson Award<br />

was introduced this year by the<br />

Australian Save Sight Institute and<br />

the Department of Ophthalmology<br />

at the University of Sydney, where<br />

both A/Prof Sanderson and Grills<br />

taught.<br />

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Aimed at ophthalmology<br />

educators, it was introduced to<br />

recognise the legacy of Gordon<br />

Sanderson as a pre-eminent<br />

teacher, said Professor Peter<br />

McCluskey, director of the Institute<br />

and chair of ophthalmology at<br />

Sydney University. “It recognises<br />

others who have made similar<br />

outstanding contributions to<br />

teaching… Richard was the<br />

obvious choice for the inaugural<br />

award. He has taught optics with<br />

Gordon from the time Gordon<br />

first arrived in Dunedin. They<br />

have both been involved in various<br />

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teaching courses - the old firstpart<br />

ophthalmology courses<br />

and the Collaborative Otago and<br />

Sydney Masters of Ophthalmology<br />

programme started by Gordon.<br />

Like Gordon, Richard is an<br />

outstanding teacher who has<br />

taught optics to generations of<br />

ophthalmologists in Australia and<br />

New Zealand. He is a most worthy<br />

and fitting recipient.”<br />

On being asked about what the<br />

award meant to him, Grills said it<br />

was a great honour and reminisced<br />

about the good times he’d had with<br />

his friend. “Gordon was an iconic<br />

teacher of ophthalmic optics who<br />

I have known as a colleague and<br />

a great friend for about 45 years.<br />

We had several fishing outings<br />

together, both in New Zealand and<br />

Australia, and of course a few jars<br />

on too many occasions to count.”<br />

The Gordon Sanderson Award<br />

is the second award in the region<br />

introduced in memory of<br />

A/Prof Sanderson. The first, the<br />

Gordon Sanderson Scholarship,<br />

was introduced by Glaucoma<br />

New Zealand in 2017 and is<br />

awarded annually to an optometry<br />

or medical trainee from the<br />

Universities of Auckland, Otago or<br />

Sydney (reflecting where A/Prof<br />

Sanderson taught) for research or<br />

education into glaucoma. <br />

Dead eye<br />

IN TRUE JAMES BOND<br />

style, researchers from<br />

Warsaw University of Technology<br />

have trained artificial intelligence<br />

(AI) algorithms to tell the difference<br />

between the irises of dead and<br />

live people to prevent a dead<br />

person’s eyeball from being used to<br />

circumvent security measures. The<br />

team used a database of iris scans<br />

from dead bodies and living people<br />

to train the algorithm, resulting<br />

in dead irises being detected<br />

with 100% accuracy, and giving<br />

the probability of live irises being<br />

misclassified at just 1%.<br />

However, this level of accuracy<br />

is only reached after the person<br />

has been dead for 16 hours or<br />

more, said the study’s authors in<br />

MIT Technology Review. “Samples<br />

collected briefly after death can fail<br />

to provide post-mortem changes<br />

pronounced enough to serve as<br />

cues for liveness detection… giving<br />

these gruesome hackers a window<br />

of opportunity since freshly plucked<br />

eyeballs should work a treat.” <br />

NZOptics_HP_Sensity_209x147mm.indd 1<br />

14 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong><br />

15/8/18 10:51 am


Retinal surgery trends<br />

ACCORDING TO THE<br />

American Society of Retina<br />

Specialists’ (ASRS’) <strong>2018</strong> Global<br />

Trends in Retina survey, most<br />

ophthalmologist respondents<br />

had learned a new technique via<br />

online video less than 24 hours<br />

before performing it. The trend<br />

was greatest in Africa/Middle<br />

East (72.6%) and least in the US<br />

(53.8%).<br />

Most respondents also felt the<br />

greatest unmet need relating to wet<br />

age-related macular degeneration<br />

(wAMD) treatment was the<br />

availability of long-acting/sustained<br />

delivery options. While the firstline<br />

anti-vascular endothelial<br />

growth factor (anti-VEGF) agent<br />

for wAMD in Africa/Middle<br />

East and the United States was<br />

bevacizumab (Avastin), at 79.3%<br />

and 70.2% respectively, Aflibercept<br />

(Eylea) was the leading option<br />

in Asia/Pacific (41.7%), Central<br />

& South America (47.3%) and<br />

Europe (37.2%). The majority<br />

of respondents said they would<br />

consider switching anti-VEGF<br />

agents due to inadequate response<br />

after three to six injections.<br />

Treatment preference for a submacular<br />

haemorrhage due to AMD<br />

with visual acuity (VA) =20/200<br />

varied, with Africa/Middle East<br />

favouring vitrectomy with tissue<br />

plasminogen activator (t-PA)<br />

injection over anti-VEGF injection<br />

therapy, while the majority of<br />

other regions opted for anti-VEGF<br />

injection over vitrectomy with<br />

t-PA, though in Europe preference<br />

for the two options was almost<br />

evenly split.<br />

Just over half of all respondents<br />

said they performed pneumatic<br />

retinopexy less than once a month<br />

while a significant majority (70.2%-<br />

89.7%) said they had not used<br />

intraoperative optical coherence<br />

tomography (OCT). <br />

For the full article, see www.<br />

eyeonoptics.co.nz/articles/archive/<br />

global-trends-in-retina/.<br />

LaHood joins EI<br />

REFRACTIVE SURGEON<br />

Dr Ben LaHood has joined<br />

the team at Eye Institute.<br />

After graduating with<br />

distinction from Otago<br />

Medical School, Dr<br />

LaHood undertook<br />

subspecialty training in<br />

laser and cataract surgery,<br />

including astigmatism<br />

management, in Sydney<br />

before gaining further experience<br />

in the US.<br />

“Being the only candidate of<br />

the post-graduate diploma in<br />

ophthalmology to be awarded all<br />

three prizes in ophthalmic anatomy,<br />

physiology and optics from the<br />

University of Sydney, there is no<br />

denying that Ben is knowledgeable<br />

and passionate about his field,” said<br />

Eye Institute’s Dr Adam Watson.<br />

“This coupled with his warm<br />

personality and genuine interest<br />

in patient health, drives him to<br />

continue his academic<br />

pursuits in improving<br />

outcomes for his<br />

patients.”<br />

This recently resulted<br />

in Dr LaHood being<br />

awarded a grant<br />

from the European<br />

Society of Cataract and<br />

Refractive Surgeons<br />

to present his findings<br />

on his master’s topic of posterior<br />

corneal astigmatism. He also<br />

specialises in ocular surface disease<br />

as well as the management of<br />

keratoconus.<br />

Dr LaHood said it’s greatly<br />

rewarding to provide patients<br />

with refractive solutions they had<br />

considered impossible. “Joining Eye<br />

Institute has been wonderful as our<br />

technology is absolutely state of the<br />

art and the team are so experienced<br />

and helpful. I already feel like part<br />

of the family.” <br />

WWW.EYEONOPTICS.CO.NZ | 15


EDUCATION<br />

SOVS: ADVANCING CLINICAL PRACTICE<br />

The second School of Optometry and Vision<br />

Science conference promised to be thoughtprovoking<br />

and informative. It didn’t fail to<br />

deliver, reports Rebecca Findlay.<br />

AFTER THE WELCOME and<br />

mihi, Jack Phu from the Centre<br />

for Eye Health in Sydney opened<br />

this year’s University of Auckland<br />

School of Optometry and Vision<br />

Science (SOVS) conference with a<br />

talk on reconciling structure and<br />

function in disease diagnosis.<br />

He illustrated the clinical<br />

conundrum whereby some patients<br />

have a deficit in structure with<br />

an accompanying loss of visual<br />

function, whereas other patients do<br />

not appear to have loss of function.<br />

He underlined the need to use<br />

pathophysiology of the disease to<br />

understand the structure-function<br />

relationship and the importance of<br />

identifying the most appropriate<br />

clinical tests by changing how we<br />

take a patient’s history.<br />

With an increasing number<br />

of migrants in New Zealand,<br />

SOVS professional teaching fellow<br />

John McLennan challenged us<br />

to consider glaucoma in people<br />

of European ethnicity to be the<br />

exception rather than the norm.<br />

He presented a literature review<br />

highlighting the variations in<br />

prevalence of primary glaucoma<br />

with ethnicity.<br />

Robert Ng reported on his time<br />

at SUNY (the State University<br />

of New York) on his Snowvision<br />

Scholarship and discussed some<br />

of the similarities and differences<br />

between the American and New<br />

Zealand models of eye care,<br />

highlighting the lack of identity<br />

of medical optometry in New<br />

Zealand. In the US, this is more<br />

clearly defined with dilation the<br />

minimum standard of care and<br />

systemic blood pressure routinely<br />

measured by optometrists.<br />

An update on treatment for<br />

adenovirus was presented by fellow<br />

SOVS staffer Dr Geraint Phillips.<br />

A combination of povidone iodine<br />

and steroid reduces the course of<br />

the condition and prevents corneal<br />

complications. A commercial<br />

formulation is not yet available, so<br />

the drops require compounding.<br />

Dr Phillips also clarified the ability<br />

of optometrists to issue medical<br />

certificates under the Holidays<br />

Amendment Act so we can keep<br />

these patients from sharing their<br />

viruses with their colleagues.<br />

Dr Angelica Ly, also from the<br />

Centre for Eye Health, presented<br />

on multimodal imaging. She<br />

provided a concise review of<br />

imaging technologies currently<br />

available and demonstrated the<br />

multimodal imaging use with<br />

a series of case studies showing<br />

how it can improve diagnosis<br />

and disease prognostication and<br />

allow better case management.<br />

Multimodal imaging allows<br />

clinicians to ensure nothing is<br />

missed and, in some cases, it may<br />

dramatically alter the best practice<br />

management plan.<br />

Tauranga optometrist Alex Petty<br />

then discussed the need to develop<br />

a New Zealand myopia action<br />

group and undertake research to<br />

establish the prevalence of myopia<br />

Jean Choi, Zaria Burden, Grace Elliott, Zane Stellingwerf and Bradley Pillay<br />

Angelica Ly, visiting<br />

presenter, and Jenny<br />

Ogier at the low vision<br />

workshop<br />

here to support prevention and<br />

intervention measures to reduce<br />

future economic and social<br />

costs. CooperVision’s Joe Tanner<br />

continued this theme, providing<br />

a study update on MiSight 1-day<br />

contact lenses for myopia control.<br />

The lenses continue to be effective<br />

after four years and are showing<br />

good results in older children, he<br />

said.<br />

Vision science research<br />

updates<br />

Associate Professor Sam<br />

Schwarzkopf opened his talk<br />

by demonstrating variability in<br />

response to ocular illusions. He<br />

described his visual cortex tuning<br />

research and its links to perception<br />

and illustrated functional MRI<br />

methods used to model how visual<br />

objects are represented in the visual<br />

cortex.<br />

The results of a series of<br />

studies measuring recognition<br />

acuity in children were shared<br />

by Dr Lisa Hamm. She described<br />

the development of a new set of<br />

optotypes for use in children as<br />

well as the use of technology to<br />

reduce scoring variability and to<br />

estimate viewing distance.<br />

A group of current optometry<br />

undergraduate students presented<br />

results from their summer student<br />

projects on a range of topics<br />

including visual impairment in<br />

stroke (Carla Fasher), virtual<br />

reality on tear film quality and<br />

dry eye (Joyce Wong, see p39),<br />

erythropoietin on the premature<br />

sheep eye (Muthana Noori) and<br />

a novel eyelid massage device for<br />

meibomian gland dysfunction<br />

(Jasmine Feng).<br />

Workshops<br />

The afternoon consisted of<br />

two workshop sessions, with<br />

attendees able to choose from a<br />

variety of topics: myopia control,<br />

ocular imaging, orthokeratology,<br />

low vision, colour vision and a<br />

glaucoma peer review session.<br />

These workshops provided an<br />

in-depth and hands on approach<br />

to the subjects and were a great<br />

opportunity to refresh and expand<br />

knowledge of these specialist areas.<br />

Posters provided by optometry<br />

staff and postgraduate students<br />

were available for viewing<br />

throughout the day, during session<br />

breaks.<br />

The conference concluded<br />

with drinks and nibbles and a<br />

‘prize draw’ for those who had<br />

visited each of the trade displays<br />

during the day and stamped their<br />

“passports”. Congratulations to all<br />

the winners and to the School of<br />

Optometry and Vision Science on<br />

a second conference that exceeded<br />

expectations and set the bar for<br />

future events.<br />

Rebecca Findlay is a PhD candidate with<br />

the School of Optometry and Vision<br />

Science and a paediatric optometrist for<br />

Counties Manukau Health.<br />

For more from SOVS, see p48<br />

for all the glamour from this<br />

years EyeBall.<br />

16 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


DRY EYE <strong>2018</strong><br />

Dry eye in practice By<br />

Lesley Springall, editor NZ Optics<br />

SINCE OUR LAST dry eye special feature,<br />

dry eye has gone mainstream. My in-box<br />

never empties of news about the latest dry<br />

eye products and dry eye research or different<br />

organisations offering the next best thing for dry<br />

eye sufferers. Spurred on by the hard-working TFOS DEWS II team and<br />

the multitude of international ambassadors who have come to the<br />

organisation’s aid to champion dry eye in their region (see main story,<br />

this page), dry eye is finally beginning to get the attention it deserves.<br />

Since the TFOS DEWS II report was released last year, there’s been a<br />

plethora of research started, completed and ongoing; a great deal more<br />

sharing of ideas; and a far greater focus on dry eye from across the eye<br />

health spectrum, all of which can only be good for patients whose lives<br />

are often severely affected by the pain and discomfort of dry eye disease.<br />

We are proud to bring you the latest update on all things dry eye from<br />

this part of the world and further afield, recognising the collaborative<br />

efforts ongoing in dry eye today, many initiated or involving our own<br />

University of Auckland.<br />

We would like to thank the many contributors to this year’s Dry Eye<br />

Special Feature, but especially our clinical editor, Associate Professor<br />

Jennifer Craig, New Zealand’s own international dry eye expert who,<br />

with considerable time and effort on her part, makes this feature<br />

possible. Jennifer not only helps us celebrate the work on dry eye on<br />

this side of the world, but also ensures the quality and breadth of the<br />

dry eye research and news we share continues to further all of our<br />

understanding and knowledge of dry eye.<br />

TFOS DEWS II:<br />

a year on…<br />

By A/Prof Jennifer Craig, vice-chair, TFOS DEWS II<br />

IT’S BEEN A full year since the outcomes of the Tear Film & Ocular<br />

Surface Society’s second Dry Eye Workshop (now better known as TFOS<br />

DEWS II) were released to the world in a series of 10 reports that distilled<br />

the scientific evidence and provided an updated global consensus view on<br />

various aspects of dry eye… and what a year it’s been!<br />

Whether it was greater public awareness; increased recognition of<br />

the impact dry eye has on quality of life; a sense of optimism that there<br />

are more available therapeutic options than ever to make a difference<br />

to affected patients’ lives; or simply a lack of patience to see the longpromised<br />

outcomes of the two and a half years’ of effort by more than<br />

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in Washington DC in 2017. In Washington, interest was so keen, the<br />

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optometrists throughout the country, beyond just the main centres.<br />

We’ve tried to maximise the relevance of the workshop’s outcomes to<br />

clinicians in optometric practice, so a practical format to the presentations<br />

has been adopted. A conventional slide presentation has been supplemented<br />

with a relatable, live demonstration of the recommended TFOS DEWS<br />

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DRY EYE <strong>2018</strong><br />

from the first TFOS DEWS II presentation of this kind I delivered along with<br />

Professor James Wolffsohn (UK) and Professor Lyndon Jones (Canada).<br />

This was recorded by the British Contact Lens Association (BCLA) at<br />

their conference in June 2017 and is freely available at www.tearfilm.org/<br />

dettconferences-tfos_dews_ii_live_presentations/5857_5581/eng/.<br />

Attempts have been made to address different practitioner learning<br />

styles and opportunities by providing the material in multiple formats:<br />

editorials and continuing education articles as well as podcasts and online<br />

CPD. Moderating an online CPD session for international online medical<br />

information provider Medscape was a novel experience (see picture).<br />

Encouraging education and discussion…<br />

Supplementing the recommendations from the report, TFOS has<br />

further sponsored the creation of nine educational videos on diagnostic<br />

techniques – tear film stability assessment and evaluation of ocular<br />

surface staining, including lid margin staining , amongst others - www.<br />

tearfilm.org/dettconferences-diagnostic_videos/5582_5581/eng/ - as well<br />

as five videos on recommended management strategies, covering a range<br />

of therapies from lid hygiene to punctal plugging - www.tearfilm.org/<br />

dettconferences-therapeutic_treatment_videos/5583_5581/eng/. These<br />

have been designed to encourage global consistency in technique and are<br />

suitable for use by practitioners who wish to expand their skills in dry eye<br />

or brush-up on existing skills and students learning the techniques for the<br />

first time.<br />

Getting the word out to all those who might benefit was always a major<br />

goal of TFOS DEWS II. As a result, and thanks to industry sponsorship,<br />

the executive summary and in some cases, the entire report (close to 400<br />

pages) have been, or are in the process of being, translated into multiple<br />

languages, including French, Italian, German, Spanish (sponsored by<br />

Allergan), Chinese, Korean, Portuguese, Vietnamese (sponsored by<br />

Novartis), Romanian, and Turkish (sponsored by SIFI). In addition, a<br />

more layman’s version of the executive summary has been written for<br />

English-speaking patients to encourage awareness and understanding of<br />

Add data to your insights.<br />

There is quantitative data in every eye. Uncovering this information<br />

can help guide your diagnosis and management of the ocular surface.<br />

In fact, the point-of-care TearLab Diagnostic Test provides precise<br />

and predictive information regarding tear osmolarity, an important<br />

biomarker of ocular surface health.<br />

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A/Prof Craig moderating Medscape’s online CPD session<br />

the disease amongst those directly affected. This is currently also being<br />

considered for translation into other languages.<br />

…and further research and awareness<br />

The report continues to help increase awareness and recently has been<br />

used in an attempt to encourage better government funding in the US<br />

for dry eye research. In July <strong>2018</strong>, TFOS and the Alliance for Eye and<br />

Vision Research (AEVR) joined with the vision community and coalition<br />

partners (including major US stakeholders in eye care and research such as<br />

ARVO and the American Academies of Optometry and Ophthalmology)<br />

to attend a Congressional Briefing and delegation visits on Capitol Hill<br />

in Washington DC. This was the second year that the Dry Eye Awareness<br />

Month of July has been recognised in this way. The Briefing focused on<br />

TFOS DEWS II and its impact on clinical practice and research.<br />

Recognising that the work of TFOS is not possible without the help<br />

of many people, TFOS has appointed ambassadors across the world to<br />

facilitate the dissemination of ocular surface knowledge gained through<br />

TFOS DEWS II. I’m honoured to have been appointed the ambassador for<br />

New Zealand while Dr Maria Markoulli and Dr Laura Downie serve as<br />

the ambassadors for Australia. So, if you’re aware of an unmet need where<br />

TFOS might be able to assist, be sure to let us know.<br />

Where to next – creating benchmarks<br />

One of the major gaps in knowledge identified by TFOS DEWS II was the<br />

management of different subtypes and severities of DED. Certainly, we<br />

no longer expect all patients to achieve adequate resolution of symptoms<br />

from aqueous tear supplementation alone, but as we introduce a range<br />

of therapies to manage lid disease as well as lacrimal gland insufficiency,<br />

TFOS DEWS II recognises there’s a need for better evidence regarding<br />

which therapies will best suit which patients and at which point in their<br />

disease. As a starting point, a survey, to which many New Zealand clinicians<br />

contributed, has been conducted. Once analysed, the outcomes will<br />

describe how practitioners in different parts of the world are diagnosing<br />

and managing dry eye to provide a benchmark of standard of care and to<br />

highlight areas where scientific evidence is lacking and where adequately<br />

masked, randomised and controlled clinical trials should be conducted.<br />

Understanding the natural history of DED<br />

Another gap to be filled is in better understanding the natural history<br />

of DED and its common cause, meibomian gland dysfunction. To that<br />

end, through collaborations at Aston University in the UK with Professor<br />

James Wolffsohn, I was able to participate in the Royal Society’s Summer<br />

Science Symposium in London in early July. Members of the public who<br />

visited the seven-day exhibition, were offered an opportunity to learn<br />

about dry eye and to contribute to the research. This resulted in more<br />

than 1750 individuals providing data on their demographics, symptoms<br />

and comfortable staring capabilities (see p26), and around 1400 of those<br />

undergoing a rapid dry eye workup on the Oculus Keratograph 5M.<br />

This initiative has generated a wealth of data which it is anticipated will<br />

contribute to our understanding of how commonly dry eye occurs and<br />

offer insights into its relationship with age, sex and other risk factors. <br />

Associate Professor Jennifer Craig is head of the Ocular Surface Laboratory at the<br />

University of Auckland, was vice-chair of TFOS DEWS II and is clinical editor of NZ Optics’<br />

annual special feature on dry eye.<br />

18 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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DRY EYE <strong>2018</strong><br />

Ocular Surface Laboratory update<br />

By A/Prof Jennifer Craig, head of OSL<br />

OVER THE YEAR there’s been<br />

a strong team of individuals<br />

working under the Ocular Surface<br />

Laboratory (OSL) banner.<br />

We’ve had some fantastic<br />

research support on the latest stage<br />

of our exploratory work on manuka<br />

honey as a treatment for blepharitis<br />

(www.eyeonoptics.co.nz/articles/<br />

archive/honey-for-blepharitis/)<br />

from part-time research fellow Dr<br />

Andrea Cruzat, who joined us from<br />

Schepens Eye Institute in Boston.<br />

A difficult career choice required<br />

Andrea to relocate to Chile recently,<br />

sadly, but we plan to continue our<br />

collaborations and hope to work<br />

together again in future. Helping<br />

to soften the blow of Andrea’s<br />

departure, we’ve been delighted to<br />

welcome clinician scientist and full-time research fellow, Dr Alex Muntz,<br />

who joins us from the University of Waterloo where he completed his PhD<br />

under the supervision of Professor Lyndon Jones. His article in this special<br />

feature describes the research he’s been involved in, evaluating the eyelid<br />

margin at a cellular level.<br />

The lab supports a large number of research students who work<br />

diligently to complete degrees at doctoral, masters and honours level,<br />

or join us for shorter-term projects for medical programme selectives,<br />

research electives or as summer students. It’s exciting to see senior PhD<br />

students, Sanjay Marasini and Ally Xue, close to completion of their PhD<br />

studies, and we were delighted to see Dr Priyanka Agarwal, who was<br />

supervised by Dr Ilva Rupenthal and myself, successfully defend her PhD<br />

thesis recently and receive the honour of placement on the Dean’s list of<br />

Excellence.<br />

We also welcome Dr Michael Wang as the newest PhD candidate in<br />

the group. His project will focus largely on epidemiological studies of<br />

dry eye, but his extensive experience in the tear film and ocular surface,<br />

from his collaboration with the lab over many years, will no doubt see<br />

his involvement across many other areas during this time. Doctoral cosupervision<br />

opportunities extend as far as Melbourne where second-year<br />

PhD student, Ceecee Zhang (University of Auckland optometry graduate)<br />

is exploring the neurotrophic potential of omega-3 in a study in diabetes,<br />

under the primary supervision of senior lecturer, Dr Laura Downie.<br />

BOptom honours students Lexia Ah Kit, Brinda Mamidi, Alicia Han and<br />

Kylie Mann completed projects with us last year, some published examples<br />

of which are described below.<br />

We were delighted to have optometrist and now junior doctor Dr<br />

William Shew, return to the OSL to conduct a repeatability evaluation<br />

of infrared meibography and to work with Dr Simon Dean, Dr Kosar<br />

Kheirabi and the team, on projects evaluating the impact of chalazion<br />

surgery on the meibomian glands, in collaboration with Dr Brian Sloan,<br />

Olga Brochner and Kathryn Lee at Auckland Hospital. Results of this<br />

work are currently in preparation for publication, after which we hope to<br />

share the outcomes in a future issue of NZ Optics.<br />

Publishing more than 20 articles in peer-reviewed scientific optometry<br />

and ophthalmology literature last year alone, the OSL was a veritable<br />

hive of industry and all credit goes to those who worked hard to get these<br />

papers to this level.<br />

During the year, our team focused on three main dry eye disease<br />

research areas including studies relating to its epidemiology and<br />

diagnostic test refinement as well as clinical trials that seek, through<br />

clinical and laboratory testing, to evaluate the outcomes of the increasing<br />

number of therapeutic and management strategies. The following articles<br />

(entitled OSL) provide an overview of some of the recently published<br />

projects from the OSL team in each of these three areas. <br />

The Ocular Surface Laboratory (OSL) is a research facility located within the<br />

Department of Ophthalmology at the University of Auckland. Led by A/Prof Jennifer<br />

Craig, a team of clinical researchers contribute to the better understanding of ocular<br />

surface disease to improve patient management of anterior segment disorders and, in<br />

particular, dry eye disease.<br />

20 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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DRY EYE <strong>2018</strong><br />

OSL: Blinking<br />

and the tear film<br />

By Dr Michael Wang, Leslie Tien, Alicia Han, Jung Min Lee, Dabin Kim, A/Prof Jennifer<br />

Craig (Auckland) and Dr Maria Markoulli (Sydney)<br />

ALTHOUGH BLINKING TRAINING is<br />

commonly recommended as part of the multimodal<br />

management of dry eye disease, the<br />

relationship between clinical measurements<br />

of blinking patterns and markers of dry eye<br />

severity remains yet to be established. The<br />

influence of blinking patterns on tear film<br />

parameters, ocular surface characteristics<br />

and dry eye symptomology was therefore<br />

explored in a recently published age, gender<br />

and ethnicity-matched cross-sectional study 1 ,<br />

conducted by the University of Auckland Ocular<br />

Surface Laboratory (OSL), in collaboration with<br />

senior lecturer Dr Maria Markoulli from the<br />

School of Optometry and Vision Science at the<br />

University of New South Wales.<br />

A total of 154 participants were recruited<br />

in the study, of which 77 exhibited clinically<br />

detectable incomplete blinking and 77 did not.<br />

Blink rate, dry eye symptomology, tear film<br />

parameters and ocular surface characteristics<br />

were assessed in a single clinical session. The<br />

results demonstrated<br />

that incomplete blinking<br />

was associated with a<br />

two-fold increased risk<br />

of dry eye disease, as<br />

defined by the global<br />

consensus TFOS DEWS<br />

II dry eye diagnostic<br />

criteria. Participants exhibiting incomplete<br />

blinking exhibited significantly higher levels<br />

of symptoms and meibomian gland dropout,<br />

as well as poorer tear film stability, lipid layer<br />

thickness, expressed meibum quality, eyelid<br />

notching and anterior blepharitis grades.<br />

Interestingly, no significant correlations were<br />

observed between blinking frequency and<br />

ocular surface parameters.<br />

The findings of the study provide evidence<br />

in favour of the hypothesis that incomplete<br />

blinking may predispose towards the<br />

development of meibomian gland dysfunction<br />

and evaporative dry eye, through diminishing<br />

Fig 1. Partial meibomian gland drop out<br />

the flow of meibomian lipids into the tear film,<br />

which may potentially contribute towards<br />

dropout and atrophy of the meibomian glands<br />

(Fig 1). Furthermore, the potential association<br />

between incomplete blinking and development<br />

of meibomian gland dysfunction would also<br />

support current recommendations of offering<br />

blinking training as part of the multi-modal<br />

management of dry eye disease. <br />

References<br />

1. Wang MT, Tien L, Han A, Lee JM, Kim D, Markoulli M, Craig JP. Impact<br />

of blinking on ocular surface and tear film parameters. doi: 10.1016/j.<br />

jtos.<strong>2018</strong>.06.001. Ocul Surf. <strong>2018</strong>.<br />

OSL: Ethnic differences in the paediatric ocular surface<br />

By Ji Soo Kim, Dr Michael Wang and A/Prof Jennifer Craig<br />

ASIAN ETHNICITY IS recognised to be a<br />

significant risk factor for the development of dry<br />

eye disease, with a higher prevalence and severity<br />

of dry eye signs and symptoms consistently<br />

reported in Asian populations relative to<br />

Caucasian cohorts in the literature. However,<br />

the effects of environmental differences<br />

between Asian and Caucasian population<br />

studies conducted in different parts of the<br />

world, as well as the lack of consistency<br />

in methodology of earlier studies, created<br />

significant challenges when interpreting<br />

their findings.<br />

In a previous age and environmentallycontrolled<br />

cross-sectional study 1 conducted<br />

by the University of Auckland Ocular Surface<br />

Laboratory (OSL), involving 74 co-located young<br />

adults, aged between 18 to 30 years, the Asian<br />

eye was found to exhibit a significantly higher<br />

degree of meibomian gland dropout and<br />

incomplete blinking, although no significant<br />

ethnic difference in dry eye symptomology was<br />

identified in this age group. It was hypothesised<br />

that incomplete blinking may predispose towards<br />

eventual meibomian gland atrophy (see story this<br />

page) through reducing the flow of meibomian<br />

secretions and potential blockage and<br />

inflammation of the ductal system. In addition, it<br />

was thought the ethnic differences in the ocular<br />

surface observed may predispose towards a<br />

greater severity of dry eye symptomology and<br />

signs in the Asian eye with advancing age.<br />

Asian ethnicity: a significant risk factor for dry eye<br />

The TFOS DEWS II epidemiology report, released<br />

in July last year, identified limited literature<br />

on the natural history of dry eye disease, as<br />

well as studies surrounding the status of the<br />

ocular surface and tear film in the paediatric<br />

population. To help address some of these gaps<br />

in knowledge, an age and environmentallycontrolled<br />

cross-sectional study 2 of 70 co-located<br />

paediatric participants, aged between 5 and 18<br />

years, was recently conducted by the OSL.<br />

The results showed there were no significant<br />

overall ethnic differences in tear film quality, dry<br />

eye symptomology or meibomian gland dropout<br />

between the Asian and Caucasian paediatric<br />

cohorts. Nevertheless, in agreement with the<br />

previous young adult study, a higher proportion<br />

of Asian participants demonstrated incomplete<br />

blinking than Caucasian participants. Ethnic<br />

differences in meibomian gland morphology<br />

patterns were also observed, with gland<br />

shortening being more common in the Asian<br />

paediatric eye, while gland tortuosity was<br />

more frequently observed in the Caucasian<br />

eye, although the reasons for this are as yet<br />

unknown. Furthermore, Asian participants<br />

without an eyelid crease were found to exhibit a<br />

higher degree of inferior lid wiper epitheliopathy<br />

and corneal astigmatism, which would both<br />

appear to suggest possible effects from higher<br />

levels of eyelid tension.<br />

Overall, the findings of the study suggest that<br />

eyelid anatomy and tensions may potentially<br />

be implicated in the Asian ethnic predisposition<br />

towards incomplete blinking and meibomian<br />

gland dysfunction, which may eventually<br />

manifest with increased prevalence and severity<br />

of dry eye disease with advancing age. <br />

References<br />

1. Craig JP, Wang MT, Kim D, Lee JM. Exploring the Predisposition of the Asian<br />

Eye to Development of Dry Eye. Ocul Surf. 2016 Jul;14(3):385-92.<br />

2. Kim JS, Wang MT, Craig JP. Exploring the Asian ethnic predisposition to dry<br />

eye disease in a paediatric population. Ocul Surf. <strong>2018</strong> (in press).<br />

22 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


LAUNCHING<br />

LATE <strong>2018</strong>


DRY EYE <strong>2018</strong><br />

OSL: Fluorescein and tear<br />

film stability assessment<br />

By Dr Michael Wang, Dr Jennifer Mooi, Joevy Lim, Dr Andreas Müller and A/Prof Jennifer Craig<br />

TEAR FILM STABILITY measurement is<br />

an integral component of the assessment of<br />

dry eye disease. Although ocular instillation<br />

of sodium fluorescein via impregnated strips<br />

is conventionally used to visualise tear film<br />

breakup, it is also recognised to destabilise<br />

the tear film, reducing stability measurements<br />

obtained. In recent years, however, automated,<br />

non-invasive measurement techniques have<br />

become available and are recommended by<br />

the global consensus TFOS DEWS II dry eye<br />

diagnostic criteria, in preference to fluorescein<br />

breakup time measurement.<br />

Two recent studies conducted by the<br />

University of Auckland Ocular Surface<br />

Laboratory (OSL) compared tear film stability<br />

measurements obtained by the traditional<br />

fluorescein and contemporary non-invasive<br />

methods.<br />

The first, recently published randomised<br />

crossover study 1 of 74 participants (including<br />

37 dry eye patients and 37 age, gender and<br />

ethnicity-matched healthy participants)<br />

compared measurements obtained by the<br />

conventional fluorescein method with those<br />

from an automated non-invasive corneal<br />

topographer (Oculus Keratograph 5M) and<br />

evaluated their respective discriminative ability<br />

in detecting symptomatic dry eye.<br />

Automated non-invasive keratograph<br />

breakup time (NIKBUT) measurements were<br />

found to be significantly longer than fluorescein<br />

breakup time in both dry eye patients and<br />

healthy participants. The optimal diagnostic<br />

cut-off for NIKBUT was also longer, at ≤9<br />

seconds, than the best cut-off point for the<br />

fluorescein breakup time, which was shown<br />

to be ≤5 seconds. Furthermore, NIKBUT<br />

measurements had better discriminative ability,<br />

sensitivity and specificity than the conventional<br />

fluorescein breakup time test.<br />

The other prospective crossover study 2 of<br />

41 participants compared tear film breakup<br />

time measurements obtained non-invasively,<br />

with minimal fluorescein instillation (1μL),<br />

and conventional fluorescein strips (15-30<br />

μL). The results showed that breakup time<br />

values measured with conventional fluorescein<br />

instillation were significantly shortened, while<br />

those obtained with tiny amounts of fluorescein<br />

instillation compared much better to noninvasive<br />

measurement techniques.<br />

The findings suggest, that where noninvasive<br />

measures are not available, we can<br />

reduce the destabilising impact of fluorescein on<br />

clinical measurements of tear film stability by<br />

minimising the volumes we instil! <br />

References<br />

1. Wang MT, Craig JP. Comparative Evaluation of Clinical Methods of Tear Film<br />

Stability Assessment: A Randomized Crossover Trial. JAMA Ophthalmology.<br />

<strong>2018</strong>;136(3):291-294.<br />

2. Mooi JK, Wang MT, Lim J, Müller A, Craig JP. Minimising instilled volume<br />

reduces the impact of fluorescein on clinical measurements of tear film<br />

stability. Contact Lens Anterior Eye. 2017;40(3):170-174.<br />

Automated non-invasive keratograph breakup time measurements<br />

OSL: Lid cleanser versus baby shampoo for blepharitis<br />

By Dr Justin Sung, Dr Michael Wang, Sang Lee, Dr Isabella Cheung, Salim Ismail, Prof Trevor Sherwin and A/Prof Jennifer Craig<br />

BLEPHARITIS IS A common ophthalmic<br />

condition characterised by chronic eyelid<br />

inflammation and associated symptoms<br />

of ocular irritation and dry eye. It can have<br />

a profound impact on quality of life. The<br />

management of blepharitis involves both<br />

the prevention and treatment of intermittent<br />

episodes of inflammatory exacerbation and<br />

regular eyelid hygiene regimens. Warm compress<br />

therapies are commonly advised for long-term<br />

symptomatic relief.<br />

The efficacy of a dedicated eyelid cleansing<br />

formulation (TheraTears SteriLid) and diluted<br />

baby shampoo in blepharitis patients was<br />

compared in a recently published, doublemasked,<br />

randomised trial conducted by<br />

the University of Auckland Ocular Surface<br />

Laboratory (OSL) 1 . A total of 43 participants<br />

with clinical signs of blepharitis were recruited<br />

and were randomised to apply the dedicated<br />

eyelid cleanser to one eye and diluted baby<br />

shampoo to the fellow eye (from bottles that<br />

Blepharitis<br />

were identical other than the marking of right<br />

and left eye), twice daily for four weeks. Ocular<br />

symptoms, tear film quality, ocular surface<br />

characteristics and inflammatory markers were<br />

assessed at baseline and following the treatment<br />

period.<br />

The results of the trial showed that blepharitis<br />

was improved, clinically, by both treatments,<br />

including SPEED symptomology scores, superior<br />

lid wiper epitheliopathy, seborrhoeic lash<br />

crusting and lash misdirection grading. However,<br />

improvements in tear film lipid layer thickness,<br />

inferior lid wiper epitheliopathy, cylindrical<br />

collarette grading and MMP-9 expression (a<br />

marker of ocular surface inflammation), as well<br />

in SANDE symptom scores, occurred only with<br />

the dedicated eyelid cleanser. Furthermore,<br />

meibomian gland orifice capping and MUC5AC<br />

expression (a marker of goblet cell function)<br />

were found to actually worsen with baby<br />

shampoo treatment.<br />

Overall, the dedicated eyelid cleansing<br />

formulation demonstrated superior efficacy and<br />

was the preferred treatment among blepharitis<br />

patients. The findings also highlighted potential<br />

long-term adverse effects of baby shampoo<br />

treatment on goblet cell function that warrant<br />

further exploration in future studies. <br />

References<br />

1. Sung J, Wang MT, Lee SH, Cheung IM, Ismail S, Sherwin T, Craig JP.<br />

Randomized double-masked trial of eyelid cleansing treatments for<br />

blepharitis. Ocular Surface. <strong>2018</strong>;16(1):77-83.<br />

24 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


OSL: Desktop humidifier for DED relief?<br />

By Dr Michael Wang, Evon Chan, Linda Ea, Clifford Kam,<br />

Yvonne Lu, Dr Stuti Misra and A/Prof Jennifer Craig<br />

IN RECENT DECADES, the significant<br />

increase in digital screen use, both at home and<br />

at work, has been accompanied by a growing<br />

prevalence of dry eye disease worldwide. The<br />

high visual and cognitive load associated with<br />

digital screen use, along with sustained visual<br />

attention, can result in a reduction of blinking<br />

frequency by a factor of two or three times.<br />

Reduced blinking frequency or quality can<br />

compromise the delivery and distribution of<br />

tear film components over the ocular surface,<br />

leading to tear film destabilisation and breakup,<br />

and the consequent development of dry eye<br />

symptoms.<br />

Furthermore, low humidity environments<br />

are common in the modern workplace with the<br />

widespread use of air conditioning and central<br />

heating. These are recognised to exacerbate<br />

dry eye severity through creating a larger water<br />

vapour pressure gradient between the ocular<br />

surface and external environment, increasing<br />

the rate of aqueous tear evaporation.<br />

The efficacy of a USB-powered desktop<br />

humidifier to provide dry eye relief was<br />

examined in a recently published, masked,<br />

randomised, crossover trial conducted by<br />

the University of Auckland Ocular Surface<br />

Laboratory (OSL) 1 . A total of 44 participants<br />

were recruited and randomised, on separate<br />

days, to a one-hour period of continuous<br />

computer use, with and without exposure to the<br />

desktop humidifier. Tear film parameters and<br />

ocular comfort were assessed before and after<br />

computer use.<br />

The results of the study showed that while<br />

the desktop humidifier effected only a modest<br />

increase in relatively humidity locally, a<br />

significant increase in tear film stability was<br />

observed, which was associated with a higher<br />

proportion of participants reporting greater<br />

subjective ocular comfort. <br />

References<br />

1. Wang MT, Chan E, Ea L, Kam C, Lu Y, Misra SL, Craig JP. Randomized Trial<br />

of a Desktop Humidifier for Dry Eye Relief in Computer Users. Optometry &<br />

Vision Science. 2017;94(11):1052-1057.<br />

14th Annual<br />

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Saturday afternoon<br />

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Venue: Waipuna Hotel & Conference Centre.<br />

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Email: professionaleducation@eyeinstitute.co.nz<br />

We are honoured to present our <strong>2018</strong> international<br />

guest speaker, Professor Joanne Wood.<br />

Joanne is<br />

a Professor in the School of Optometry and Vision<br />

Science and has extensive research experience in<br />

several areas: vision and driving, vision and falls and<br />

clinical psychophysics. Her research experience spans<br />

over 25 years and includes a PhD in Visual Science<br />

at Aston University UK, followed by a Post-Doctoral<br />

Fellowship in Clinical Psychophysics. In 1991, Professor<br />

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laboratory. This lab uses an experimental design, incorporating measurements of actual<br />

driving performance on a closed circuit driving course, as well as on the open road,<br />

rather than making indirect judgements via crash rate data or driving simulators. This<br />

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Thanks to our Conference Sponsors<br />

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WWW.EYEONOPTICS.CO.NZ | 25


DRY EYE <strong>2018</strong><br />

OSL:Tear supplements vs the environment<br />

By Dr Akilesh Gokul, Dr Michael Wang and A/Prof Jennifer Craig<br />

ADVERSE ENVIRONMENTAL<br />

CONDITIONS, including high airflow velocity<br />

and low relative humidity, are recognised to<br />

exacerbate dry eye signs and symptoms. Topical<br />

artificial tear supplements are among the most<br />

commonly used therapies for dry eye disease,<br />

although the protective effects of eye drop<br />

application prior to the exposure of adverse<br />

environmental conditions have not yet been<br />

established.<br />

The prophylactic efficacy of a lipomimetic<br />

eye drop (Systane Balance) and a non-lipid<br />

containing drop (Systane Ultra) were compared<br />

in a recently published, double-masked,<br />

randomised trial conducted by the University<br />

of Auckland Ocular Surface Laboratory (OSL)¹.<br />

A total of 30 patients with symptomatic dry eye<br />

were recruited and randomised to lipomimetic<br />

drop application in one eye and the non-lipid<br />

containing drop in the fellow eye. Participants<br />

were then exposed to a validated simulated<br />

adverse environment model and tear film<br />

quality and dry eye symptomology assessed<br />

at baseline and following exposure to the<br />

simulated adverse environment.<br />

The results of the trial showed that<br />

both therapies resulted in an immediate<br />

improvement in tear film stability and<br />

prevented its decline below baseline following<br />

simulated adverse environment exposure.<br />

However, improvements in tear film lipid layer<br />

quality and the prevention of its decline below<br />

baseline was limited only to the lipomimetic<br />

drop which, interestingly, also demonstrated<br />

superior post-instillation and post-exposure<br />

tear film stability, lipid layer thickness and<br />

ocular comfort than the non-lipid containing<br />

eye drop.<br />

Overall, the findings demonstrated<br />

that application of both lipid and nonlipid<br />

containing eye drops conferred<br />

prophylactic efficacy against exposure<br />

to adverse environmental conditions in<br />

patients with symptomatic dry eye. However,<br />

the lipomimetic drop conferred superior<br />

protective effects and was the preferred<br />

treatment among dry eye patients. <br />

References<br />

1. Gokul A, Wang MTM, Craig JP. Tear lipid supplement prophylaxis<br />

against dry eye in adverse environments. Cont Lens Anterior Eye. <strong>2018</strong><br />

Feb;41(1):97-100.<br />

Blink test for DED<br />

By Prof James Wolffsohn, Maria Vidal-Roht,<br />

Sonia Trave Huarte, A/Prof Jennifer Craig, Lexia Ah-Kit<br />

and Dr Michael Wang<br />

THE OPTREX DRY EYE BLINK TEST 1 is a simple,<br />

online self-assessment tool which provides<br />

patients and clinicians with a convenient and<br />

rapid preliminary screening instrument for dry<br />

eye disease, without the need for specialist<br />

instrumentation or the instillation of ocular<br />

dyes. The Blink Test measures the amount of<br />

time taken following two, non-forceful blinks<br />

for a patient to experience symptoms of ocular<br />

discomfort or dry eye.<br />

A recently published diagnostic accuracy study,<br />

jointly conducted by the Aston University<br />

Ophthalmic Research Group and the University<br />

of Auckland Ocular Surface Laboratory,<br />

evaluated the discriminative ability of the Blink<br />

Test in detecting patients with dry eye disease,<br />

as defined by the global consensus TFOS DEWS II<br />

diagnostic criteria.<br />

A total of 87 participants were recruited and<br />

the study results demonstrated that the Blink<br />

Test values were significantly correlated with<br />

tear film stability, dry eye symptomology<br />

scores, conjunctival staining and lid wiper<br />

epitheliopathy. At the optimal diagnostic cut<br />

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for the latest news, features, research updates,<br />

event photos, job adverts and more.<br />

28 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


DRY EYE <strong>2018</strong><br />

OSL: Cosmetics and the tear film<br />

By Dr Michael Wang and A/Prof Jennifer Craig<br />

Eye cosmetics are widely used by mostly female populations of all age<br />

groups globally for religious, cultural and cosmetic purposes. The literature<br />

surrounding the effects of eye cosmetics on tear film quality and dry<br />

eye disease was assessed by a recent review 1 conducted by University of<br />

Auckland Ocular Surface Laboratory (OSL) researchers.<br />

Consistent evidence, both cross-sectional and prospective, was identified<br />

for the migration of cosmetic products across the eyelid margin and into<br />

the tear film. This compromises the quality of the surface lipid layer of<br />

the tear film and predisposes towards tear film instability and dry eye<br />

symptoms. Multiple adverse effects and complications associated with<br />

eye cosmetic wear have also been reported, raising the possibility that<br />

tear film contamination with cosmetic products may be associated with<br />

ocular surface inflammatory responses, which can contribute to further<br />

predisposition towards the development of dry eye disease. Prospective<br />

studies have also shown that eyeliner application at the inner eyelash line,<br />

known as ‘tightlining’, results in a higher degree of tear film contamination<br />

and ocular discomfort than application to the outer periocular skin.<br />

Finally, a recently published investigator-masked randomised trial of 50<br />

participants 2 , conducted by OSL, also demonstrated that eye cosmetic wear<br />

may have the potential to compromise the efficacy of topical lipid-based<br />

dry eye treatments. <br />

References<br />

1. Wang MT, Craig JP. Investigating the effect of eye cosmetics on the tear film: current insights. Clinical Optometry.<br />

<strong>2018</strong>;10:33-40.<br />

2. Wang MT, Cho ISH, Jung SH, Craig JP. Effect of lipid-based dry eye supplements on the tear film in wearers of eye<br />

cosmetics. Contact Lens Anterior Eye. 2017;40(4):236-241.<br />

Microblepharon exfoliation to improve CL comfort<br />

By Sowjanya Siddireddy, Dr Ajay Kumar Vijay, Dr Jackie Tan-Showyin and Prof Mark Willcox<br />

CONTACT LENS WEAR is associated with discomfort. This presents a<br />

real problem for wearers, practitioners and industry as discomfort is one<br />

of the main reasons for contact lens wearers to drop out of lens wear.<br />

At the School of Optometry and Vision Science at the University of<br />

New South Wales we have recently studied whether changes to ocular<br />

microbiota are associated with discomfort during wear and whether<br />

microblepharon exfoliation of the lid margin changes the ocular<br />

microbiota and if this is associated with improved comfort.<br />

We enrolled 30 contact lens wearers, measured their comfort during<br />

lens wear using the CLDEQ-8 questionnaire and swabbed their eyelids.<br />

The swabs were then cultured to identify and enumerate the types of<br />

microbes colonising the lids. Culture and identification used standard<br />

microbiological techniques. We then either washed their eyelids once with<br />

a foam cleanser or used the foam cleanser along with microblepharon<br />

exfoliation with BlephEx. After treatment, we gave them the CLDEQ-8<br />

questionnaire again and swabbed their eyelids for microbial identification<br />

and enumeration. We then left the subjects for 7-10 days and repeated the<br />

CLDEQ-8 and microbial workup to assess which changes lasted for that<br />

time period.<br />

Treating eyes with either a foam cleanser or the foam cleanser with<br />

microblepharon exfoliation improved the comfort of symptomatic lens<br />

wearers (CLDEQ-8 >12 points). By 7-10 days after treatment, with the<br />

foam cleanser alone, the scores of symptomatic wearers improved by two<br />

points on the CLDEQ-8 scale, but they remained above the cut-off of 12<br />

and so were still classified as symptomatic. On the other hand, use of the<br />

foam cleanser with the microblepharon exfoliation improved the CLDEQ-8<br />

scores by six points and most symptomatic wearers had scores below 12,<br />

converting them to asymptomatic wearers.<br />

Symptomatic lens wearers were found to have approximately 50% more<br />

microbes on their lids than asymptomatic wearers. The foam cleanser<br />

alone reduced the number of microbes on eyelids of symptomatic wearers<br />

by approximately 50% within 7-10 days after treatment. Treatment with<br />

microblepharon exfoliation reduced microbe numbers by 60% in the<br />

same post-treatment timeframe. Gram-negative bacteria were isolated<br />

from symptomatic lens wearers only and were significantly reduced from<br />

baseline to follow-up with both treatments.<br />

This data points to the importance of contact lens wearers maintaining<br />

good lid hygiene. Practitioners should consider treating the lids of contact<br />

lens wearers who are complaining of discomfort during wear and also<br />

talking to the wearers about how they could improve the hygiene of their<br />

lids. <br />

Sowjanya Siddireddy is a clinician and researcher at the School of Optometry and Vision<br />

Science at the University of New South Wales in Sydney, working with research fellows Dr<br />

Ajay Kumar Vijay and Dr Jackie Tan-Showyin, and with Professor Mark Willcox. Prof Wilcox<br />

specialises in ocular microbiology, ocular inflammation and infection and bio-prospecting.<br />

His current research focuses on understanding the aetiology of adverse events and<br />

comfort during contact lens wear, including adhesion and biofilm formation of ocular<br />

pathogenic microbes and development of novel antimicrobial surfaces.<br />

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DRY EYE <strong>2018</strong><br />

Cataract surgery and dry eye<br />

By Dr Stuart Carroll<br />

CATARACT SURGERY IS one of the most<br />

common elective surgical procedures performed<br />

worldwide. Advancements with surgical<br />

instrumentation and lens implant technology<br />

have made it increasingly popular as a treatment<br />

for both visual rehabilitation and refractive<br />

correction. Patient expectations have never been<br />

higher, and superb results with rapid recovery<br />

are readily achievable. Sounds great, right, so<br />

what’s the problem? “My eyes are constantly<br />

irritated… they were never like that before the<br />

surgery, doctor!”<br />

Unfortunately, dry eye disease (DED), while<br />

frequently dismissed as a minor annoyance<br />

following cataract surgery, can be a significant<br />

cause of patient dissatisfaction, visual symptoms<br />

and poor surgical outcomes. Preoperatively,<br />

accurate biometric measurements require an<br />

optimal ocular surface state 1 . Furthermore, the<br />

numerous presbyopia-correcting IOL options that<br />

are becoming increasingly popular, are notoriously<br />

unforgiving with regard to visual quality in the<br />

presence of a suboptimal ocular surface.<br />

The prevalence of ocular surface signs in the<br />

patient demographic that undergoes cataract<br />

surgery is extremely high. In the PHACO<br />

study, 77% of patients had corneal staining<br />

preoperatively 2 . Although, many of these<br />

patients may be asymptomatic 3 , disruption of<br />

the delicate homeostasis of the tear film and<br />

ocular surface can lead to manifestation of<br />

symptoms which then become frustratingly<br />

difficult to manage reliably, despite the<br />

significant advances in our understanding of<br />

DED and its treatment options. Several studies<br />

have indicated that patient symptoms and signs<br />

are negatively influenced by cataract surgery<br />

and some may take up to six months to recover 4 .<br />

The TFOS DEWS II report represents an<br />

extensive body of work led by world experts in<br />

dry eye, and their recently published iatrogenic<br />

dry eye report presents a comprehensive<br />

literature review which includes cataract<br />

surgery 5 . There is no question that many<br />

interventions involved in cataract surgery are<br />

responsible for post-operative DED. The most<br />

likely perpetrators are topical medications<br />

(and their preservatives) used pre- and postoperatively,<br />

oxygen free radicals and proinflammatory<br />

cytokines generated in response<br />

to surgical trauma, and the corneal incisions<br />

which invariably sever corneal nerves. Similar,<br />

though more extensive, corneal nerve injury is<br />

well described following LASIK surgery where<br />

postoperative dry eye is one of the chief sources<br />

of postoperative dissatisfaction. Light toxicity<br />

from the operating microscope has also been<br />

implicated. Diabetic patients in particular seem<br />

to be more at risk of iatrogenic DED 5 .<br />

Therefore, a comprehensive dry eye<br />

evaluation should be performed for all<br />

prospective cataract surgery patients. Preoperative<br />

recognition and optimisation of DED<br />

signs and symptoms is a critically important<br />

factor in managing such patients. Ideally this<br />

should begin at the point of referral, when<br />

surgery is being considered. The TFOS DEWS<br />

II reports are an ideal source for up-to-date<br />

diagnosis and management recommendations.<br />

Avoiding topical preservatives in at-risk<br />

patients, minimising postoperative drop toxicity<br />

and actively managing dry eye symptoms with<br />

Fig 1. Fluorescein dye showing poor tear film homogeneity and<br />

break-up. Credit: Dr Dean Corbett<br />

topical lubricants where necessary are simple<br />

measures that can help post-operatively.<br />

On the horizon, “dropless cataract surgery”<br />

(where intraocular slow-release preparations of<br />

steroid and antibiotic are used instead of topical<br />

post-operative medications) may be a useful<br />

step forward in preventing DED in cataract<br />

surgery patients. Stay tuned!<br />

Laser refractive surgeons recognised all of<br />

this long ago and consider it standard care to<br />

treat dry eye pre- and post-operatively. We<br />

should all adopt the same standard of care for<br />

our cataract patients. <br />

References<br />

1. Epitropolous AT et al. Effect of tear osmolarity on repeatability of keratometry<br />

for cataract surgery planning. J Cat Refract Surg 41(8):1672-7.<br />

2. Trattler WB et al. The Prospective Health Assessment of Cataract Patients’<br />

Ocular Surface (PHACO) study: the effect of dry eye. Clin Ophthalmol. 2017;<br />

7(11):1423-30.<br />

3. Cochener B et al. Prevalence of meibomian gland dysfunction at the time<br />

of cataract surgery. J Cataract Refract Surg. <strong>2018</strong> Feb;44(2):144-148<br />

4. Xue W et al. Long-term impact of dry eye symptoms on vision-related quality<br />

of life after phacoemulsification surgery. Int Ophthalmol. <strong>2018</strong> Feb 1. doi:<br />

10.1007/s10792-018-0828-z. [Epub ahead of print]<br />

5. Gomes JAP et al. TFOS DEWS II iatrogenic report. The Ocular Surface<br />

(2017) 15(3):511-38.<br />

Dr Stuart Carroll is a consultant ophthalmologist<br />

at Auckland Eye and Greenlane Clinical Centre in<br />

New Zealand with specialist knowledge in cataract<br />

and refractive surgery, strabismus and paediatric<br />

ophthalmology.<br />

Castor oil for dry eye? Demodex?<br />

By Dr Emma Sandford and Grant Watters, with A/Prof Jennifer Craig<br />

CASTOR OIL HAS a long and ancient history<br />

as a traditional remedy for skin, scalp and hair<br />

ailments, and internally for gastrointestinal<br />

and reproductive applications. It is even<br />

mentioned in herbal medicine lists on papyrus<br />

from ancient Egypt.<br />

Today, castor oil continues to appear<br />

intermittently in online searches for natural<br />

treatments for blepharitis, so we’ve decided<br />

to study its effects in relation to dry eye,<br />

specifically with respect to anterior blepharitis<br />

and Demodex mites, and examine its likely<br />

mechanisms of action, in a scientific manner.<br />

Castor oil’s main constituent is ricinoleic acid,<br />

which has a number of properties applicable<br />

to the different facets of the pathophysiology<br />

of blepharitis and dry eye. It is an emollient,<br />

anti-inflammatory, anti-microbial, anti-oxidant,<br />

and a surfactant with lipid layer-forming<br />

abilities, so it spreads across the tear film in<br />

a thin layer. It penetrates the lash follicles<br />

and there is every reason to<br />

suspect it might interfere with<br />

the physiology of Demodex mites,<br />

rather like tea tree oil.<br />

We are employing a unique<br />

rollerball application method,<br />

which ensures application of a thin<br />

film close to the lid margins. The<br />

hypothesis is this may have some<br />

therapeutic benefit in controlling blepharitis and<br />

Demodex, along with the possibility that a small<br />

degree of ingress into the tear film will enhance<br />

the lipid layer and could potentially address lipid<br />

layer deficiency which leads to dry eye symptoms<br />

associated with blepharitis.<br />

Under the guidance of Associate Professor<br />

Jennifer Craig, we are conducting a prospective,<br />

randomised, investigator-masked trial of<br />

topically-applied castor oil for blepharitis as<br />

an optometry honours research project. This<br />

is being conducted by Part V students, Marna<br />

Auckland optometry student<br />

Marna Claassen demonstrating the<br />

castor oil rollerball lid applicator<br />

Claassen, Lauren Curd and Alice<br />

Jackson, who are recording<br />

a range of subjective and<br />

objective parameters to elicit<br />

symptomatic and biometric<br />

changes of the eyelids and<br />

tear film, including changes in<br />

ocular surface inflammatory<br />

biomarkers. We are excited to<br />

find out, when the data are<br />

unmasked at the conclusion<br />

of the study, whether a onemonth<br />

application period has<br />

resulted in improvements in these parameters<br />

and lower titres of inflammatory markers.<br />

If so, this could infer long-term benefits<br />

with respect to minimising ocular surface<br />

inflammation and reducing the incidence of<br />

dry eye in blepharitis patients.<br />

We are currently recruiting for this study. For<br />

more information and to check eligibility<br />

please call or text us on 022 EYE PAIN.<br />

Dr Emma Sandford is a GP in the Bay of Plenty and<br />

an honorary academic, and Grant Watters is an<br />

optometrist and researcher at the University of<br />

Auckland.<br />

30 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


Understanding the “lid wiper”<br />

By Dr Alex Muntz<br />

WE BLINK AROUND 10,000 times a day, with the eyelids traversing the<br />

length of a football pitch in distance each day. Wiping over the eye’s<br />

surface with every blink is the “lid wiper”, a 1-2mm thin portion of the<br />

inner eyelid margin. We assume that friction is increased here during<br />

blinking, especially when lubrication is sub-par because of an altered<br />

tear film, or by wearing contact lenses. Higher friction may induce a<br />

mechanical or hyperosmotic insult<br />

of the lid wiper, driving symptoms<br />

of dryness and discomfort in dry eye<br />

and contact lens patients.<br />

Fig 1. LWE on the everted upper eyelid<br />

margin, shown by lissamine green staining<br />

Clinically, this association appears<br />

to be reflected in “lid wiper<br />

epitheliopathy” (LWE), a staining<br />

pattern observed at the upper<br />

and/or lower lid margins following<br />

lissamine green instillation and lid<br />

eversion (Fig 1). But if vital stains<br />

are able to highlight a degree of cellular damage, what does this damage<br />

look like at a cellular level?<br />

While dry eye and contact lens wear are recognised to be associated<br />

with cellular changes of the ocular surface (including within the cornea,<br />

limbus and bulbar conjunctiva), we know surprisingly little about<br />

clinically-relevant variations in the cellular anatomy and physiology<br />

of the lid wiper; the area in exclusive apposition with the eye’s surface<br />

during blinking. The cornea, bulbar or tarsal conjunctival are commonly<br />

and easily assessed by application and removal of a membrane to<br />

which superficial cells adhere. This “impression cytology” technique is<br />

a quick and convenient tool for sample collection from patient prior<br />

to histological cellular analysis. However, the narrow, sharply curved<br />

lid margin does not easily lend itself to such a sampling method. The<br />

optimisation of impression cytology for lid marginal use was the focus of<br />

my PhD studies at the University of Waterloo in Canada. During this time,<br />

we determined the ideal membrane material, the optimal location, angle<br />

and pressure, and the duration of application (Fig 2). We chose specialised<br />

histological dyes that change their colour according to the keratinisation<br />

level of cells to reflect friction at the lid margin (Fig 3).<br />

Armed with this new tool, lid marginal epithelial cells were collected from<br />

patients presenting with varying levels of LWE, including contact lens<br />

wearers and non-lens wearers with a range of self-reported discomfort<br />

and dryness levels. By investigating the cellular morphology (size, shape,<br />

state, type, number of cells etc.) of the lid margin and its correlation with<br />

clinical signs and subjective symptoms, we are hoping to shed new light<br />

on the role of this region for dry eye and contact lens patients.<br />

A video demonstrating this technique as well as our published methods<br />

paper are available at www.imuntz.com/ic. Stay tuned for a full report on<br />

these studies in an upcoming issue of<br />

NZ Optics! <br />

Reference and pictures reproduced with permission, courtesy<br />

of A Muntz, K van Doorn, L N Subbaraman, L W Jones,<br />

Impression cytology of the lid wiper area, J Vis Exp. (2016)<br />

e54261–e54261.<br />

Dr Alex Muntz, an optometrist, is a postdoctoral<br />

research fellow in the Ocular Surface<br />

Laboratory at the University of Auckland and<br />

was previously a clinical research scientist<br />

with the University of Waterloo’s Centre for<br />

Ocular Research & Education<br />

Dry Eye<br />

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Fig 2. Impression cytology on<br />

the upper lid wiper region<br />

Fig 3. Cells of the lid wiper region<br />

show varying morphology and<br />

different keratinisation degrees<br />

through differential staining dyes: no<br />

keratinisation (a); advanced keratinisation<br />

(c); and incipient keratinisation (b)<br />

WWW.EYEONOPTICS.CO.NZ | 31


DRY EYE <strong>2018</strong><br />

Ocular allergy<br />

and dry eye<br />

By Prof James Wolffsohn<br />

OCULAR ALLERGY REPRESENTS a group of<br />

hypersensitivity disorders that primarily affects<br />

the conjunctiva.<br />

The most common form of ocular allergy<br />

is seasonal allergic conjunctivitis (SAC),<br />

accounting for 90% of cases¹ , ². The most<br />

prevalent allergens in SAC are grass, tree and<br />

weed pollen, and outdoor moulds². In the<br />

United Kingdom, the prevalence of ocular<br />

allergy to grass pollen in patients attending<br />

optometric practice is estimated to be 8%³ – no<br />

data is currently available from Australasian<br />

countries.<br />

Similar to dry eye, although the signs and<br />

symptoms of SAC are usually mild, they may<br />

hinder school performance, work productivity<br />

and everyday tasks such as driving 4 . The<br />

primary treatment strategy for SAC involves<br />

avoidance of the offending allergen to prevent<br />

the initiation of the allergic response. However,<br />

complete avoidance is not often possible and<br />

use of topical anti-allergic medications is<br />

required when signs and symptoms occur 5 .<br />

While non-pharmacological treatments, such<br />

as artificial tears developed for dry eye and cold<br />

compresses have been used for many years, in<br />

conjunction with allergen avoidance strategies<br />

and anti-allergic medications to help bring<br />

about symptomatic relief 5,6 , evidence showing<br />

the effectiveness of this approach has only<br />

relatively recently been published 7 . In this study,<br />

patients had controlled exposure to grass pollen<br />

and either used cold compresses or artificial<br />

tears, resulting in therapeutic effects on the<br />

signs and symptoms of allergic conjunctivitis. A<br />

cold compress enhanced the use of epinastine (a<br />

mast cell stabiliser/antihistamine combination)<br />

and was the only treatment to reduce symptoms<br />

to baseline within an hour of antigenic<br />

challenge. Signs of allergic conjunctivitis were<br />

generally reduced most by a combination of<br />

cold compress and artificial tears or epinastine.<br />

In a separate, recent study, acute allergic<br />

rhinoconjuctivitis has been shown to be<br />

characterised by tear hyperosmolarity, which<br />

can be rehabilitated with the administration of<br />

hypotonic artificial tears, much like dry eye 8 .<br />

Considerable overlap of reported symptoms<br />

of itch and dryness has been reported in groups<br />

with presumed dry eye and seasonal allergic<br />

conjunctivitis 9 . As with ocular allergy, there can<br />

be seasonal (summer and winter) and weatherrelated<br />

aspects to dry eye symptoms 10 . Similar<br />

biomarkers for the biological ‘diagnosis’ of both<br />

dry eye and ocular allergy have been proposed 11 ,<br />

along with imaging techniques such as in-vivo<br />

confocal microscopy 12 , but these have not been<br />

adopted clinically.<br />

Dry eye symptoms are generally greater in<br />

those with ocular allergy 13 and some ocular<br />

allergy medications can induce signs and<br />

symptoms of dry eye 14 . Hence it would seem<br />

that clinically the conditions are often confused<br />

and careful questioning of when the symptoms<br />

occur is advised to aid with the selection of<br />

appropriate management. <br />

References<br />

1. Abelson MB, Leonardi A, Smith L. The mechanisms, diagnosis and treatment<br />

of allergy. Rev Ophthalmol 2002;9:74-84.<br />

2. Bielory L. Ocular allergy overview. Immunology Allergy Clin 2008;28:1-23.<br />

3. Wolffsohn JS, Naroo SA, Gupta N, Emberlin J. Prevalence and impact of<br />

ocular allergy in the population attending UK optometric practice. Contact<br />

Lens Ant Eye 2011;34:133-8.<br />

4. Smith AF, Pitt AD, Rodruiguez AE, et al. The economic and quality of life<br />

impact of seasonal allergic conjunctivitis in Spanish setting. Ophthalmic<br />

Epidemiol 2005;12:233-42.<br />

5. Bielory L. Ocular allergy treatment. Immunology Allergy Clin 2008;28:189-<br />

224.<br />

6. Chigbu DI. The management of allergic eye disease in primary care. Contact<br />

Lens Ant Eye 2009;32:260-72.<br />

7. Bilkhu PS, Wolffsohn JS, Naroo SA, Robertson L, Kennedy R. Effewctivenes<br />

of non-pharmaceutical treatments for acute seasonal conjunctivitis.<br />

Ophthalmology 2014;121:72-8.<br />

8. Nitoda E, Lavaris A, Laios K, Androudi S, Kalogeropoulos CD, Tsatsos M,<br />

Damaskos C, Garmpis N, Moschos MM. Tear Film Osmolarity in Subjects<br />

with Acute Allergic Rhinoconjunctivitis . In Vivo <strong>2018</strong>;32:403-8.<br />

9. Hom MM, Nguyen AL, Bielory L. Allergic conjunctivitis and dry eye<br />

syndrome. Annals Allergy, Asthma, Immunol 2012;108:163-6.<br />

10. van Setten G, Labetoulle M, Baudouin C, Rolando M. Evidence of seasonality<br />

and effects of psychrometry in dry eye disease. Acta Ophthalmol 2016;94:499-<br />

506.<br />

11. Enriquez-de-Salamanca A, Bonini S, Calonge M. Molecular and cellular<br />

biomarkers in dry eye disease and ocular allergy. Curr Opin Allergy Clin<br />

Immunol 2012;12:523-33.<br />

12. Villani E, Mantelli F, Nucci P. In-vivo confocal microscopy of the ocular<br />

surface: ocular allergy and dry eye . Curr Opin Allergy Clin Immunol<br />

2013;13:569-76.<br />

13. Vehof J Smitt-Kamminga NS, Nibourg SA, Hammond CJ. Predictors of<br />

discordance between symptoms and signs in dry eye disease. Ophthalmol<br />

2017;124:280-6<br />

14. Ousler GW, Workman DA, Torkildsen GL. An open-label, investigatormasked,<br />

crossover study of the ocular drying effects of two antihistamines,<br />

topical epinastine and systemic loratadine, in adult volunteers with seasonal<br />

allergic conjunctivitis. Clin Therapeutics 2007;29:611-6.<br />

Professor James Wolffsohn is pro-vice chancellor of<br />

Aston University, Birmingham, England and was a subcommittee<br />

chair for TFOS DEWS II. His main research<br />

areas include the development and evaluation of<br />

ophthalmic instrumentation, contact lenses, intraocular<br />

lenses and the tear film.<br />

32 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


DED and the<br />

Dunedin Study<br />

By Dr Graham Wilson, A/Prof Jennifer Craig and Dr<br />

Michael Wang<br />

THE DUNEDIN MULTIDISCIPLINARY<br />

Health and Development Study is a wellestablished,<br />

large longitudinal study on human<br />

health, development, ageing and behaviour,<br />

which has been ongoing for more than 40 years.<br />

The study has been tracking more than 1000<br />

participants since they were born in 1972 or<br />

1973. In 2017, for the first time, dry eye disease<br />

(DED) was included as part of the study, as the<br />

participants turn 45.<br />

TFOS DEWS II identified significant gaps in<br />

the existing dry eye literature, including a lack<br />

of population-based prevalence studies from the<br />

Southern Hemisphere over the past decade, as<br />

well as limited scientific literature investigating<br />

the natural history of DED. The TFOS DEWS<br />

II epidemiology subcommittee also identified<br />

a significant shortage of scientific evidence,<br />

which is needed to provide a comprehensive<br />

understanding of the risk factors for DED and<br />

to better understand the relationship between<br />

medical conditions and dry disease.<br />

It is hoped that the dry eye arm of the<br />

Dunedin Study will be able to help address<br />

some of the identified gaps in the current dry<br />

eye literature, through characterising ocular<br />

surface and tear film parameters within a<br />

large, age-controlled cohort based in the<br />

Southern Hemisphere, exploring the potential<br />

interactions between systemic conditions and<br />

DED and assessing whether dry eye may be a<br />

biomarker of the ageing process.<br />

Data collection is currently well underway<br />

and it is hoped the findings will be released over<br />

the next two years. <br />

Dr Graham Wilson is a Gisborne-based ophthalmologist<br />

and principal investigator for all eye-related matters on<br />

the Dunedin Study. A/Prof Jennifer Craig and Dr Michael<br />

Wang are based at the Ocular Surface Laboratory at the<br />

University of Auckland.<br />

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33


DRY EYE <strong>2018</strong><br />

Dry eye and autologous serum<br />

By Dr Nick Mantell<br />

THE TEAR FILM and ocular<br />

surface are extremely complex,<br />

with tear film playing a vital role<br />

in maintaining ocular surface<br />

health. Not only does it provide<br />

lubrication but also many<br />

neuropeptides, vitamins and<br />

growth factors essential for the<br />

health of the corneal epithelium.<br />

Given the complexity of the tear<br />

film, it seems a small miracle that it<br />

functions normally in anyone.<br />

Meanwhile dry eye disease<br />

(DED) is encountered on a daily<br />

basis by eye health professionals<br />

and accounts for a range of mild<br />

to severe discomfort symptoms<br />

(pain, burning sensations, eye<br />

fatigue, light sensitivity, redness<br />

etc.) made worse by virtually<br />

all types of ocular surgery. The<br />

worsening of this condition<br />

post-surgery is fortunately<br />

present for only a finite period for<br />

most people and will eventually<br />

return to its preoperative level.<br />

As ophthalmologists, we see this<br />

regularly after refractive laser<br />

procedures, but also after cataract<br />

and retinal surgery (see p30). Less<br />

commonly, surgery exacerbates<br />

severe ocular surface disease<br />

following chemical trauma, or<br />

associated with neurotrophic<br />

epithelial defects, or conjunctival<br />

cicatrising conditions like Stevens<br />

Johnston syndrome.<br />

“...SEDs are recognised by most<br />

factors in the tear film are vital to<br />

the health of the ocular surface,<br />

supplementing these proteins<br />

has not, to date, been an integral<br />

component of DED treatment.<br />

This has, in part, been because<br />

the actions of these factors have<br />

not been well understood, but it<br />

has also been difficult to isolate<br />

ophthalmologists as an important option<br />

for some dry eye disease patients who have<br />

not responded to other treatments.”<br />

Traditionally when treating<br />

DED, we focus on optimising the<br />

lipid layer on the surface of the<br />

tear film to reduce the evaporation<br />

of tears and facilitate spreading of<br />

the tear film on the ocular surface;<br />

maintaining or supplementing the<br />

aqueous layer to normalise the<br />

osmolarity of the tear film; and<br />

treating any concurrent ocular<br />

inflammation, typically with<br />

steroids.<br />

Although it is recognised that<br />

the neuropeptides and growth<br />

and produce these proteins. With<br />

the increasing recognition of<br />

the prevalence and significant<br />

socioeconomic costs of this<br />

condition, however, there has been<br />

renewed interest in DED.<br />

In the 1970s, doctors recognised<br />

that many of the proteins and<br />

growth factors present in the tear<br />

film were also present in serum.<br />

Autologous serum eye drops<br />

have been used with considerable<br />

success in patients with severe<br />

chemical burns. Then, in the 1980s,<br />

the application of serum eye drops<br />

was extended to the treatment<br />

of other forms of severe ocular<br />

surface disease and non-healing<br />

neurotrophic corneal ulcers,<br />

resulting in significant clinical<br />

evidence for the benefit of serum<br />

in these conditions (Fig 1 and Fig<br />

2).<br />

In 1984, Fox et al published a<br />

paper showing autologous serum<br />

eye drops (SEDs) were helpful in<br />

treating severe DED, leading to<br />

increasing interest in this area.<br />

However, it is still not considered<br />

a mainstream therapy for this<br />

condition. This is partly because<br />

of the logistics of generating SEDs,<br />

but also because clinical trials have<br />

demonstrated variable benefits<br />

with respect to treating dry eye.<br />

A recent Cochrane review,<br />

based on a limited number<br />

of randomised clinical trials,<br />

demonstrated that SEDs alleviate<br />

dry eye symptoms better than<br />

artificial eye drops for the first<br />

couple of weeks, but data still<br />

remains inconclusive regarding<br />

clinical efficacy over long-term<br />

periods.<br />

SEDs are essentially prepared by<br />

taking a patient’s blood, allowing<br />

it to clot, then spinning it in a<br />

centrifuge to separate the red<br />

blood cells from serum. The serum<br />

is then removed and mixed in<br />

varying proportions with normal<br />

saline, before being separated into<br />

bottles, each with enough serum to<br />

provide up to a week’s treatment.<br />

These are then frozen and, at the<br />

beginning each week’s treatment, a<br />

single bottle is defrosted.<br />

Preparing SEDs involves a<br />

considerable amount of resource<br />

and there is a small risk of<br />

contamination if not handled<br />

appropriately, so it’s important the<br />

patient is fully informed about the<br />

need for careful handling. There<br />

are also strict protocols regarding<br />

drop preparation. These may<br />

vary from one service to another,<br />

although my understanding is<br />

that this is standardised across<br />

the New Zealand blood service,<br />

where the drops are 25% serum<br />

and 75% saline. In other countries<br />

50% or 100% serum mixtures<br />

may be used. Unfortunately, there<br />

isn’t consensus in the literature<br />

regarding the most effective serum<br />

concentration.<br />

If a patient is unable to give<br />

blood due to concurrent medical<br />

conditions, it is also possible to<br />

prescribe allogenic serum eye<br />

drops. These are prepared in the<br />

same way as autologous serum eye<br />

drops, except the blood is sourced<br />

from another patient.<br />

As medical professionals, we<br />

like our practices to be guided<br />

by sound scientific evidence<br />

regarding clinical efficacy. The<br />

clinical evidence for treating<br />

chemical ocular burns, severe<br />

ocular surface disease (Stevens<br />

Johnston Syndrome) and nonhealing<br />

neurotrophic ulcers<br />

is relatively strong, however a<br />

similar level of evidence does not<br />

yet exist for DED. Despite this,<br />

SEDs are recognised by most<br />

ophthalmologists as an important<br />

option for some DED patients<br />

who have not responded to other<br />

treatments. It is generally accepted<br />

that not all, but many patients<br />

show clinical improvement on this<br />

treatment, when other traditional<br />

treatments fail.<br />

The lack of evidence highlights<br />

the difficulties in running clinical<br />

trials on conditions that have, until<br />

34 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


ecently with TFOS DEWS II, been<br />

relatively ill-defined, and where<br />

clinical signs often show very<br />

little relationship to the patient’s<br />

symptoms.<br />

Serum drops remain an evolving<br />

therapeutic option. Some groups<br />

are now using other blood-derived<br />

products which may offer superior<br />

therapeutic benefits over standard<br />

SEDs. The first is Eye PRP which<br />

uses a process to create platelet<br />

enriched plasma with a reportedly<br />

higher concentration of growth<br />

factors. The second is ‘plasma rich<br />

in growth factors’ PRGF which uses<br />

a different process again to increase<br />

the concentration of growth<br />

factors. Preliminary trials involving<br />

both preparations have shown<br />

clinical benefits.<br />

Finally, Moorfield’s Eye Hospital<br />

ran a small trial where patients<br />

were taught how to use a drop<br />

of whole blood from a pinprick<br />

on their finger, four times a<br />

day for eight weeks. Significant<br />

improvements were noted in<br />

several parameters, such as visual<br />

acuity, corneal staining, tear<br />

break-up time (TBUT) and ocular<br />

comfort index (OCI), but not the<br />

Schirmer’ test.<br />

So, we can expect more exciting<br />

developments to come in this area.<br />

<br />

References<br />

1. Alio JL, Arnalich-Montiel F, Rodriguez AE. The role of<br />

“eye platelet rich plasma (E-PRP)” for wound healing in<br />

ophthalmology. Curr Pharm Biotechnol (2012)<br />

2. Anitua E, de la Fuente M, Riestra A, Merayo-Lloves J,<br />

Muruzabal F, Orive G. Preservation of biological activity<br />

of plasma and platelet-derived eye drops after their<br />

different time and temperature conditions of storage.<br />

Cornea (2015)<br />

3. Del Castillo JM, de la Casa JM, Sardina RC, et al.<br />

Treatment of recurrent corneal erosions using autologous<br />

serum. Cornea 2002;21:781–3.<br />

4. Fox RI, Chan R, Michelson JB, et al. Beneficial effect<br />

of artificial tears made with autologous serum in<br />

patients with keratoconjunctivitis sicca. Arthritis Rheum<br />

1984;27:459–61<br />

5. Lopez-Plandolit S, Morales MC, Freire V, Grau AE,<br />

Duran JA. Efficacy of plasma rich in growth factors for<br />

the treatment of dry eye. Cornea (2011)<br />

6. Pan Q, Angelina A, Marrone M, Stark WJ, Akpek EK.<br />

Autologous serum eye drops for dry eye. Cochrane<br />

Database Syst Rev (2017)<br />

7. Than J, Balal S, Wawrzynski J, Nesaratnam N, Saleh<br />

GM, Moore J, Sharma A et al. Fingerprick autologous<br />

blood: a novel treatment for dry eye syndrome. Eye<br />

(Lond) (2017)<br />

8. Tsubota K , Goto E, Fujita H, et al. Treatment of dry eye<br />

by autologous serum application in Sjögren’s syndrome.<br />

Br J Ophthalmol 1999;83:390–5<br />

9. Tsubota K , Satake Y, Ohyama M, et al. Surgical<br />

reconstruction of the ocular surface in advanced ocular<br />

cicatricial pemphigoid and Stevens-Johnson syndrome<br />

[see comments]. Am J Ophthalmol 1996;122:38–52.<br />

Dr Nick Mantell specialises in cataract,<br />

laser vision correction and vitreoretinal<br />

surgery with the Eye Institute in Auckland<br />

and is a former clinical senior lecturer<br />

with the Department of Ophthalmology<br />

at Auckland University<br />

Fig 1. Neurotrophic ocular surface disease, due to presumed HSV,<br />

prior to treatment with SEDs<br />

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the oily lipid layer of the tear, reduce inflammation resulting in improved tear production and<br />

tear film break-up time. Lacritec is specially formulated based from this research and because it is<br />

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WWW.EYEONOPTICS.CO.NZ | 35


DRY EYE <strong>2018</strong><br />

Diabetes, dry eye and ‘substance P’?<br />

By Drs James Slater and Stuti Misra<br />

DIABETES HAS NOW reached epidemic<br />

proportions affecting millions of people across<br />

the world. It is estimated around 54% of patients<br />

with diabetes suffer from some degree of dry eye<br />

syndrome 1 .<br />

Patients with diabetes commonly complain of<br />

burning and foreign body sensation in their<br />

eyes. In severe cases, this may result in reduced<br />

corneal sensitivity, aberrant wound healing<br />

ability of the cornea, increased risk of infection<br />

and the eventual development of diabetic<br />

neurotrophic keratopathy 2 . Interestingly, there<br />

is growing evidence of the involvement of<br />

neurotransmitters in the tear film offering an<br />

interesting potential pathway for future ocular<br />

surface treatment strategies 3 .<br />

Chronic hyperglycaemia, diabetic peripheral<br />

neuropathy, decreased insulin levels,<br />

microvasculopathy and systemic hyperosmotic<br />

disturbances are the most common risk<br />

factors for diabetes mellitus associated dry<br />

eye syndrome (DMDES). Insulin is critical for<br />

proliferation of the acinar lacrimal gland and<br />

corneal epithelial cells, whereas hyperglycaemia<br />

induces significant histological changes in the<br />

lacrimal gland. This suggests a strong role of<br />

oxidative stress in dry eye syndrome. A number<br />

of factors, however, are responsible for ocular<br />

surface changes in patients with diabetes which<br />

ultimately may lead to corneal nerve damage<br />

(fig 1).<br />

Substance P is a neuropeptide released from the<br />

trigeminal nerve endings located in the cornea,<br />

lacrimal gland and conjunctiva 4 . In isolation and<br />

with other hormones (including neuropeptide Y,<br />

gene-related peptide, insulin-like growth factor<br />

1 and vasoactive-intestinal peptide) substance<br />

P plays a crucial role in wound healing while<br />

providing maintenance and nutrition to the<br />

cornea by promoting the migration, proliferation<br />

and differentiation of corneal epithelial cells.<br />

In diabetes, substance P levels decrease,<br />

contributing to poorer wound healing and<br />

increased susceptibility to corneal neurotrophic<br />

ulcers, due to decreased epithelial migration 5 .<br />

This finding has been confirmed in a recent<br />

pilot study by Markoulli et al (see p38). which<br />

compared patients with diabetes to a healthy<br />

control group 5 . Substance P also decreases in<br />

spinal fluid and the peripheral nervous system<br />

which plays an important role in causing<br />

diabetic peripheral neuropathy 6 . Evidently,<br />

diclofenac decreases the levels of Substance P in<br />

the tear film, something one might want to take<br />

into account when using Voltaren eye drops in<br />

patients with diabetes 7 . Substance P and insulin<br />

growth factor-1, however, reportedly show<br />

good efficacy in healing neurotrophic diabetic<br />

keratopathy, but these treatment options are yet<br />

to be completely explored.<br />

Where to from here<br />

A number of studies focusing on<br />

neurotransmitters and their potential role<br />

in treating diabetes-associated dry eye are<br />

underway or planned. As well as focusing on<br />

diabetic retinopathy, the leading cause of<br />

blindness in diabetes, significant attention<br />

needs to be paid to DMDES in clinical practice<br />

as it can have a severe effect on quality of life.<br />

The pathogenesis of DMDES, however, remains<br />

elusive and further clinical trials are warranted<br />

and ongoing by different research groups in the<br />

UK, Australia and also Auckland.<br />

We will certainly have more to report on this<br />

interesting topic in next year’s review of dry eye<br />

research in the region. <br />

References<br />

1. Manaviat MR, Rashidi M, Afkhami-Ardekani M, Shoja MR. Prevalence of<br />

dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC<br />

Ophthalmol 2008;8:10.<br />

2. Alves Mde C, Carvalheira JB, Modulo CM, Rocha EM. Tear film and ocular<br />

surface changes in diabetes mellitus. Arq Bras Oftalmol 2008;71:96-103.<br />

3. Nishida T, Inui M, Nomizu M. Peptide therapies for ocular surface<br />

disturbances based on fibronectin–integrin interactions. Progress in retinal<br />

and eye research 2015;47:38-63.<br />

4. Davidson HJ, Kuonen VJ. The tear film and ocular mucins. Veterinary<br />

ophthalmology 2004;7:71-77.<br />

5. Markoulli M, You J, Kim J, et al. Corneal nerve morphology and tear film<br />

substance P in diabetes. Optometry and Vision Science 2017;94:726-731.<br />

6. Marfurt CF, Echtenkamp SF. The effect of diabetes on neuropeptide content<br />

in the rat cornea and iris. Investigative ophthalmology & visual science<br />

1995;36:1100-1106.<br />

7. Yamada M, Ogata M, Kawai M, Mochizuki H, Mashima Y. Topical<br />

diclofenac sodium decreases the substance P content of tears. Archives of<br />

Ophthalmology 2002;120:51-54.<br />

Dr James Slater is a clinical research fellow in the<br />

New Zealand National Eye Centre at the University of<br />

Auckland, where he is focusing on corneal nerves and<br />

diabetes. Dr Stuti Misra is a lecturer and researcher at<br />

the University’s Department of Ophthalmology. Her<br />

research focus includes ocular surface abnormalities<br />

and corneal imaging.<br />

Fig 1. A range of factors lead to nerve damage in diabetes<br />

36 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


Image modified from "Stern, Beuerman, & Pflugfelder (2004)<br />

Fig 1. Healthy tear film (left) and unstable tear film (right), typically characterised by (A) a<br />

discontinuous lipid layer, (B) a hyperosmolar aqueous layer and (C) reduced mucins and goblet cells<br />

Not all eye drops are created equal!<br />

By Drs Priyanka Agarwal and Ilva Rupenthal<br />

DEFICIENCY IN TEAR film quality and<br />

quantity are often considered key defining<br />

characteristics of dry eye disease (DED).<br />

The complex, dynamic multi-component<br />

structure, which comprises an underlying<br />

aqueous-mucous layer and a superficial lipid<br />

layer, synergistically maintains ocular surface<br />

homeostasis. Functionally, the aqueous-mucus<br />

layer is believed to improve the wettability<br />

and support corneal adhesion of the tear film,<br />

while the lipid layer tends to form a superficial<br />

protective “blanket”, providing an occlusive<br />

effect. “Holes” in the blanket (see Fig 1), as<br />

typically observed in evaporative DED and<br />

especially in meibomian gland dysfunction, can<br />

increase exposure of the underlying aqueous<br />

layer of the tear fluid to the environment and<br />

evaporation, leading to hyperosmolarity of the<br />

tear film and epithelial apoptosis. Consequently,<br />

artificial tears are frequently used for the<br />

management of tear film deficiencies. However,<br />

the term “artificial tears” is a misnomer as<br />

most products do not mimic the complex<br />

composition of human tears and contrary to<br />

their name, they typically “supplement” rather<br />

than “replace” the tear fluid.<br />

Artificial tear supplements can be isotonic<br />

or hypotonic aqueous eye drops, which may<br />

have additional viscosity building agents<br />

such as carboxymethylcellulose (Refresh,<br />

Allergan), hydroxypropyl guar (Systane, Alcon)<br />

or sodium hyaluronate (Hylo-Forte, AFT<br />

Pharmaceuticals). They typically function by<br />

augmenting the aqueous layer and transiently<br />

reducing tear fluid osmolarity; however, their<br />

effect is generally short-lived due to rapid<br />

drainage and evaporation from the ocular<br />

surface. Osmoprotective agents, such as<br />

trehalose and erythritol (believed to reduce<br />

the concentration of intracellular organic salts<br />

without disturbing cellular macromolecular<br />

components) may also be added to aqueous<br />

eye drops to reduce hyperosmolar stress. On<br />

the other hand, lipid-based eye drops, which<br />

generally contain amphiphilic lipids and/or<br />

surfactants, fortify the tear film lipid layer to<br />

inhibit excessive evaporation.<br />

Lipid-based artificial tear supplements are<br />

generally believed to have a more sustained<br />

effect than non-lipid eye drops and may be<br />

superior in the management of DED, especially<br />

when it is associated with meibomian gland<br />

dysfunction. For instance, instillation of lipidbased<br />

eye drops has shown a significantly<br />

greater improvement in tear film lipid layer<br />

thickness and consequent reduction in tear<br />

evaporation in patients with DED, resulting in<br />

superior prophylactic efficacy on exposure to<br />

desiccating environmental stress 1 .<br />

Consequently, several lipid-based artificial<br />

tear supplements have been developed with<br />

the objective of reducing tear evaporation and<br />

providing long-term relief to patients with dry<br />

eyes. Lipid-based eye drops are most frequently<br />

available in the form of oil-in-water emulsions<br />

such as Cationorm (Santen SAS) or ointments<br />

such as VitA-POS (AFT Pharmaceuticals).<br />

Liposomal sprays such as Optrex ActiMist<br />

(Optima Pharmazeutische), which potentially<br />

improve tear film integrity by replenishing<br />

the phospholipid layer at the aqueouslipid<br />

interface, have also shown significant<br />

improvement in tear film quality 2 .<br />

A significant concern with long-term eye<br />

drop use, however, is the presence of irritating<br />

preservatives, which can compromise the<br />

ocular surface and worsen patient discomfort.<br />

Surfactants typically used to prepare oil-inwater<br />

lipid-based eye drops may also exacerbate<br />

dry eye symptoms by transiently destabilising<br />

the tear film. Consequently, several surfactants<br />

have been listed in the TFOS DEWS II<br />

iatrogenic report as agents that potentially<br />

cause dry eye 3 . In an attempt to avoid such<br />

components, a preservative-free lipid layer<br />

stabilising eye drop has recently been developed<br />

by Novaliq using a novel, optically transparent,<br />

non-aqueous, semifluorinated alkane. This<br />

product is currently marketed as EvoTears<br />

(Ursapharm) in Europe and as NovaTears<br />

(AFT) in Australia and New Zealand and has<br />

shown promising results in multi-centre clinical<br />

trials performed in patients with evaporative<br />

dry eye disease 4 . Recent research has also shown<br />

that semifluorinated alkanes can be used as a<br />

vehicle for delivery of therapeutic agents to the<br />

eye 5 and potentially simplify the dosage regimen<br />

for patients with chronic dry eye disease. <br />

References<br />

1. Gokul A, Wang MTM, Craig JP. Tear lipid supplement prophylaxis against<br />

dry eye in adverse environments. Contact Lens and Anterior Eye. 2017.<br />

2. Craig JP, Purslow C, Murphy PJ, et al. Effect of a liposomal spray on the preocular<br />

tear film. Contact Lens and Anterior Eye. 2010;33(2):83-7.<br />

3. Gomes JAP, Azar DT, Baudouin C, et al. TFOS DEWS II iatrogenic report.<br />

The Ocular Surface. 2017;15(3):511-38.<br />

4. Steven P, Scherer D, Krösser S, et al. Semifluorinated Alkane Eye Drops for<br />

Treatment of Dry Eye Disease--A Prospective, Multicenter Noninterventional<br />

Study. Journal of Ocular Pharmacology and Therapeutics. 2015;31(8):498-<br />

503.<br />

5. Agarwal P, Scherer D, Günther B, et al. Semifluorinated alkane based systems<br />

for enhanced corneal penetration of poorly soluble drugs. International<br />

Journal of Pharmaceutics. <strong>2018</strong>;538(1):119-29.<br />

Dr Priyanka Agarwal is currently a research fellow in the<br />

University of Auckland’s School of Pharmacy. Her research<br />

interests include drug delivery and bench-to-bedside<br />

formulation development. Dr Ilva Rupenthal is a senior<br />

lecturer in the University of Auckland’s Department of<br />

Ophthalmology and director of the Buchanan Ocular<br />

Therapeutics Unit (www.botu.nz), which aims to translate<br />

ocular therapeutic-related scientific research into the<br />

clinical setting. Disclosure: Dr Agarwal’s doctoral studies,<br />

supervised by Dr Rupenthal, were funded by Novaliq GmbH,<br />

manufacturer of NovaTears.<br />

WWW.EYEONOPTICS.CO.NZ | 37


DRY EYE <strong>2018</strong><br />

Trans-Tasman dry eye research collaborators Dr Maria Markoulli, Dr Stuti Misra, A/Prof Jennifer Craig and Dr Laura Downie at ARVO <strong>2018</strong><br />

The immune system, the nervous system<br />

and the ocular surface<br />

By Drs Maria Markoulli, Luisa Colorado and Katie Edwards<br />

A CHARACTERISTIC OF dry eye disease (DED)<br />

is the presence of inflammation, a significant<br />

driving factor of the vicious circle that is<br />

DED. TFOS second dry eye workshop (TFOS<br />

DEWS II) aptly described this process as being<br />

initiated by evaporative water loss leading to<br />

hyperosmolar tissue damage. This contributes<br />

to the inflammatory cascade, with an increased<br />

presence of inflammatory markers in the<br />

tear film, such as matrix metalloproteinase-9<br />

(MMP-9)¹. These changes cause damage to<br />

both epithelial and goblet cells, manifesting in<br />

the clinical signs of corneal and conjunctival<br />

staining and reduced tear break-up time. This<br />

further feeds into the initial hyperosmolarity,<br />

perpetuating the process². This cycle of events<br />

also causes damage to the corneal nerves³<br />

which provide nutritional support to the corneal<br />

epithelium by releasing factors important for<br />

growth and wound healing, such as substance<br />

P⁴. Epithelial cells reciprocate by providing<br />

support to corneal nerves by secreting growth<br />

factors that promote nerve growth⁴. In DED, the<br />

equilibrium of these supporting growth factors<br />

and inflammatory markers is affected.<br />

A possible relationship has been described<br />

between the ocular surface immune and<br />

nervous systems⁵. To understand what impact<br />

DED has on these systems, it is important to<br />

first understand what is normal in the healthy<br />

eye. This can help us understand what we need<br />

to do to maintain the equilibrium of the ocular<br />

surface. To do this, we set out to understand the<br />

relationship between corneal nerve structure<br />

and the presence of inflammatory mediators<br />

and neuromediators in the tear film. We<br />

collected the tears of 21 healthy participants<br />

and also took images of their corneal nerves<br />

using an in vivo corneal confocal microscope.<br />

We found that neuromediator substance P in<br />

the tear film correlated with measures of nerve<br />

fibre morphology, where higher levels were<br />

associated with a greater number of nerves.<br />

We also found that higher levels of tissueinhibitor<br />

of MMPs (TIMP-1) and the inflammatory<br />

mediator interleukin-6 (IL-6) were associated<br />

with a reduced presence of corneal nerves.<br />

These results confirm the immune and nervous<br />

systems in the ocular surface are interlinked and<br />

that what affects one, may affect the other.<br />

Another exciting finding from our research was<br />

that a higher number of hours spent sleeping<br />

meant a higher number of corneal nerves being<br />

present, and more hours spent exercising was<br />

associated with thicker corneal nerves. This<br />

reinforces the need for a greater understanding<br />

into the impact that exercise and sleep have on<br />

the nervous system and the impact that such<br />

modifiable factors might have on ocular health.<br />

With the understanding of the healthy ocular<br />

surface, we can now look towards understanding<br />

how this changes in DED and work towards<br />

restoring its equilibrium. <br />

References<br />

1. Chotikavanich, S, CS de Paiva, Q Li de, JJ Chen, F Bian, WJ Farley and SC<br />

Pflugfelder (2009). “Production and activity of matrix metalloproteinase-9<br />

on the ocular surface increase in dysfunctional tear syndrome.” Invest<br />

Ophthalmol Vis Sci 50(7): 3203-3209.<br />

2. Bron, AJ, CS de Paiva, SK Chauhan, S Bonini, EE Gabison, S Jain, E Knop,<br />

M Markoulli, Y Ogawa, V Perez, Y Uchino, N Yokoi, D Zoukhri and DA<br />

Sullivan (2017). “TFOS DEWS II pathophysiology report.” Ocul Surf 15(3):<br />

438-510.<br />

3. Belmonte, C, JJ Nichols, SM Cox, JA Brock, CG Begley, DA Bereiter, DA<br />

Dartt, A Galor, P Hamrah, JJ Ivanusic, DS Jacobs, NA McNamara, MI<br />

Rosenblatt, F Stapleton and JS Wolffsohn (2017). “TFOS DEWS II pain and<br />

sensation report.” Ocul Surf 15(3): 404-437.<br />

4. Muller, LJ, CF Marfurt, F Kruse and TM Tervo (2003). “Corneal nerves:<br />

structure, contents and function.” Exp Eye Res 76(5): 521-542.<br />

5. Cruzat, A, D Witkin, N Baniasadi, L Zheng, JB Ciolino, UV Jurkunas, J<br />

Chodosh, D Pavan-Langston, R Dana and P Hamrah (2011). “Inflammation<br />

and the nervous system: the connection in the cornea in patients with<br />

infectious keratitis.” Invest Ophthalmol Vis Sci 52(8): 5136-5143.<br />

Dr Maria Markoulli is an optometrist and senior<br />

lecturer at the University of New South Wales School<br />

of Optometry and Vision Science. Dr Luisa Colorado is<br />

a post-doctoral research fellow and Dr Katie Edwards a<br />

lecturer at the School of Optometry and Vision Science<br />

at the Queensland University of Technology.<br />

38 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


VR to tackle work DED?<br />

By Dr Philip Turnbull<br />

THE MODERN WORKPLACE is a<br />

hostile environment for a dry eye sufferer.<br />

Computer use decreases blink frequency and<br />

completeness, leading to lipid layer breakdown<br />

and increased aqueous tear evaporation, while<br />

air-conditioned office environments frequently<br />

further aggravate the disrupted tear film.<br />

As an academic, I spend a large part of<br />

my day in front of a computer and I am not<br />

immune to the feeling of tired, gritty eyes at the<br />

end of the day. When developing applications<br />

for virtual reality (VR), however, my eyes<br />

felt some relief. To explore this, optometry<br />

student Joyce Wong joined Associate Professor<br />

Jennifer Craig and me in the Ocular Surface<br />

Laboratory at the University of Auckland to<br />

complete a summer studentship, investigating<br />

whether the use of VR can influence the tear<br />

film. Participants attended two visits that were<br />

randomised in order: one where they used a<br />

desktop computer; and another where they<br />

wore a VR headset. Within the VR headset we<br />

projected a ‘virtual desktop’, which meant an<br />

image of the real desktop monitor could be<br />

seen and used within the headset, like a movie<br />

projecting onto a cinema screen. A battery<br />

of dry eye tests were performed before and<br />

immediately after 40 minutes of computer use.<br />

There was little change in the temperature<br />

and relative humidity during the desktop<br />

condition, but there was a significant increase<br />

in the temperature of the air within the VR<br />

headset (from the ambient 22°C to 31°C),<br />

which warmed the anterior eye by 0.6°C. This is<br />

hypothesised to have increased meibum output<br />

as the lipid layer thickness was, on average,<br />

almost one grade higher after VR, whereas<br />

thinning of the lipid layer was observed after<br />

desktop use. This translated to a functional<br />

change in tear film quality, such that the tear<br />

breakup time increased by about three seconds<br />

following VR use while it decreased by three<br />

seconds after desktop viewing.<br />

VR headsets also offer other advantages, like<br />

shifting the focal plane towards the distance<br />

so that only distance spectacle prescriptions<br />

need to be worn and no accommodation is<br />

required and the ability to transform the work<br />

environment to somewhere more pleasant,<br />

perhaps a mountaintop or beach.<br />

The promising results of our study,<br />

combined with improvements in virtual reality<br />

By providing a heated microenvironment, VR headsets may<br />

improve the comfort of computer use for dry eye sufferers<br />

technologies and ergonomics, suggest VR may<br />

become a viable option for dry eye suffers who<br />

are otherwise unable to use a computer. <br />

Dr Philip Turnbull is a lecturer in the School of<br />

Optometry and Vision Science at the University of<br />

Auckland. His research involves developing new tools<br />

using technology such as eye tracking and virtual reality<br />

to investigate visual function.<br />

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WWW.EYEONOPTICS.CO.NZ | 39


DRY EYE <strong>2018</strong><br />

So you want to set up a dry eye clinic?<br />

By A/Prof Jennifer Craig<br />

IT’S BECOME CLEAR, as<br />

our knowledge has evolved,<br />

that dry eye management, if<br />

performed thoroughly, cannot<br />

be squeezed into a normal<br />

examination as part of a standard<br />

eye examination. You wouldn’t<br />

expect to perform a full glaucoma<br />

work-up within a standard<br />

eye examination and neither<br />

should you expect to perform a<br />

detailed dry eye assessment in<br />

this time. This specialised area<br />

requires time, dedicated staff<br />

and an individualised approach,<br />

in the development of the final<br />

management plan.<br />

Preliminary testing<br />

The TFOS DEWS II diagnostic<br />

process leads us through the most<br />

important features of a dry eye<br />

assessment 1 . The first critical<br />

component is history-taking<br />

as this allows the clinician to<br />

develop an understanding of the<br />

individual presenting patient. In a<br />

symptomatic patient, the clinician<br />

must first establish that dry eye<br />

is the most likely problem. This<br />

requires a triaging process, to<br />

help differentiate dry eye from<br />

other underlying causes of ocular<br />

surface discomfort, such as allergy<br />

or infection. Having the patient<br />

answer such triaging questions,<br />

with the aid of a questionnaire<br />

either prior to their appointment<br />

or via an interview with the<br />

assistance of ancillary staff, before<br />

diagnostic testing takes place<br />

can help streamline the process,<br />

especially when it comes to<br />

recording successes and failures<br />

of previous dry eye treatment<br />

attempts. The same is true in<br />

determining relevant risk factors.<br />

A pre-attendance checklist will<br />

allow key information to be passed<br />

to the clinician about possible dry<br />

eye aetiologies and modifiable risk<br />

factors, that will allow for more<br />

focused history-taking on site and<br />

can be addressed as appropriate<br />

within the management plan.<br />

TFOS DEWS II recommends<br />

using one of two validated<br />

questionnaires for evaluating the<br />

symptoms component of a dry<br />

eye diagnosis: the Ocular Surface<br />

Disease Index (OSDI) and the<br />

five-item Dry Eye Questionnaire<br />

(DEQ-5). One or other should be<br />

chosen, noting the appropriate<br />

cut-off for a positive score for each.<br />

Adopting the same questionnaire<br />

within any one practice is advisable<br />

to facilitate monitoring even if the<br />

patient sees a different practitioner.<br />

The symptom recording, like the<br />

triaging and risk factor assessment,<br />

can be undertaken prior to<br />

attendance but is ideally completed<br />

in the waiting room immediately<br />

before consultation as symptoms<br />

are best recorded on the same day<br />

as the clinical signs are evaluated.<br />

Clinical testing<br />

Dry eye can be diagnosed with<br />

instrumentation ranging from<br />

the slit lamp that’s available in<br />

every clinical practice, through to<br />

complex standalone equipment<br />

such as the Keratograph 5M<br />

(Oculus) or TearScience Lipiview<br />

II (Johnson & Johnson). A variety<br />

of other standalone devices and<br />

slit-lamp-mounted instruments<br />

offer diagnostic capabilities<br />

somewhere in between. The<br />

instrumentation available for<br />

clinical testing in any individual<br />

practice will dictate the order<br />

in which testing should be<br />

Clinical<br />

parameter<br />

Basic testing<br />

Advanced testing<br />

Symptoms OSDI or DEQ-5 OSDI or DEQ-5<br />

Global testing<br />

Subtype testing<br />

for aqueous<br />

deficiency<br />

Subtype testing<br />

for evaporative<br />

dry eye<br />

1. Stability testing with minimal<br />

fluorescein<br />

2. Osmolarity may be unavailable<br />

3. Fluorescein and lissamine green<br />

staining of cornea, conjunctiva and lid<br />

margin<br />

Tear meniscus height (slit lamp estimate)<br />

Phenol red thread (moderately invasive)<br />

Schirmer test (useful when applied<br />

without anaesthetic only for confirming<br />

severe aqueous deficiency, as highly<br />

invasive test)<br />

1. Lid margin assessment (thickening,<br />

rounding, notching, telangiectasia,<br />

capped orifices, etc.)<br />

Table 1. Standard and advanced tests for DED diagnosis<br />

performed. Tests must be<br />

conducted the same way each time,<br />

and ordered from least invasive<br />

to most invasive to minimise<br />

the effect of reflex tearing on<br />

subsequent test results.<br />

Encompassing as many of the<br />

global tests that contribute to a<br />

diagnosis of dry eye (according<br />

to TFOS DEWS II) as possible is<br />

ideal – along with symptoms: at<br />

least one positive result from tests<br />

for tear film stability, osmolarity,<br />

and ocular surface staining is<br />

needed to make a diagnosis.<br />

Conducting additional tests for<br />

subtyping is also important as this<br />

helps confirm whether the dry eye<br />

is primarily aqueous-deficient or<br />

evaporative in nature (see Table 1).<br />

The move towards more<br />

non-invasive and objective<br />

testing of the tear film may mean<br />

well-trained ancillary staff could<br />

perform (although not interpret)<br />

parts of the assessment, rather<br />

than the clinician themselves.<br />

Interpretation of the combined<br />

set of results (the more tests, the<br />

better) by the clinician should<br />

2. Lash assessment for madarosis, poliosis,<br />

misdirection, crusting and cylindrical<br />

collarettes<br />

3. Diagnostic gland expression performed<br />

digitally to evaluate meibum<br />

expressibility and quality<br />

be used to inform the patient’s<br />

tailored management strategy.<br />

Management strategies<br />

Consideration must be given to the<br />

treatments and recommendations<br />

that will be offered to patients who<br />

are diagnosed with dry eye disease<br />

(DED). Artificial tear supplements<br />

remain the mainstay of treatment,<br />

but therapies that address both<br />

evaporative as well as aqueousdeficient<br />

subtypes of dry eye need<br />

to be considered (see other articles<br />

in this feature). This may involve<br />

stocking lipid supplements, lid<br />

hygiene products, including those<br />

that tackle Demodex infestation,<br />

and microwaveable wheat or bead<br />

bags for warm compress therapy,<br />

through to offering punctal<br />

plugging for aqueous deficiency<br />

or advanced treatments such as<br />

IPL (intense pulsed light) therapy<br />

and LipiFlow for evaporative dry<br />

eye associated with meibomian<br />

gland dysfunction. Offering<br />

other in-practice therapies<br />

such as BlephEx to remove<br />

crusting associated with anterior<br />

blepharitis (see article, p29),<br />

1. Non-invasive tear film stability<br />

assessment (using reflected mires)<br />

2. Osmolarity testing<br />

3. Fluorescein and lissamine green staining<br />

of cornea, conjunctiva and lid margin<br />

Tear meniscus height quantified digitally<br />

from infrared imaging (IR minimises risk of<br />

reflex tearing)<br />

1. Lid margin assessment (as for basic<br />

testing, plus infrared meibography)<br />

2. Lash assessment (as for basic, plus<br />

epilation for Demodex evaluation under<br />

100x light microscopy)<br />

3. Diagnostic gland expression for meibum<br />

expressibility and quality performed with<br />

Korb Meibomian Gland Evaluator<br />

4. Lipid layer interferometry<br />

40 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


SOVS’ dry eye clinic opens<br />

By Dr Geraint Phillips<br />

OPTOMETRISTS ARE BECOMING<br />

increasingly aware of the<br />

challenges facing dry eye<br />

patients. Compliance with home<br />

treatments for dry eye can be<br />

variable and patient adherence<br />

to treatment instructions tend to<br />

diminish following an enthusiastic<br />

start. The recent TFOS DEWS II<br />

report provides excellent current<br />

information about the diagnosis<br />

and management of dry eye.<br />

With this in mind, the University<br />

of Auckland School of Optometry<br />

and Vision Science (SOVS) is<br />

planning to establish a dry eye<br />

clinic which will be open to referrals<br />

from community optometrists.<br />

The clinic will be well equipped,<br />

and its aim will be to expose our<br />

final year optometry students to<br />

evidence-based, best practice dry<br />

eye care. This in turn will give our<br />

new graduates the confidence to<br />

take their skills and knowledge<br />

into practice to ensure the public<br />

receives world-class care in this<br />

field. As well as providing detailed<br />

diagnoses and recommendations for<br />

home therapies, a range of in-office<br />

treatments will also be available.<br />

We are very fortunate to have<br />

Associate Professor Jennifer Craig<br />

as our advisor and the clinic will<br />

be led by Dr Marcy Tong, a SOVS<br />

professional teaching fellow who<br />

already has significant experience<br />

in diagnosing and manging dry<br />

eye disease. To attract referrals and<br />

maximise student exposure to dry<br />

eye cases, we will endeavour to set<br />

fees for this service at a level that<br />

will allow access by all patients who<br />

might benefit.<br />

Planning for this clinic is now well<br />

underway and SOVS will announce<br />

more details in the coming months.<br />

The start date will be the beginning<br />

of March 2019.<br />

We look forward to offering<br />

comprehensive dry eye care<br />

to the patients of community<br />

optometrists while at the same<br />

time providing research-led, first<br />

class teaching to our students.<br />

Dr Geraint Phillips, clinic director,<br />

University of Auckland School of<br />

Optometry and Vision Science<br />

Ed’s note: In separate news, the<br />

University of New South Wales<br />

School of Optometry and Vision<br />

Science (SOVS) announced it has<br />

newly launched a dry eye clinic<br />

which it hopes will become a statewide<br />

referral centre for the diagnosis,<br />

imaging and management of the<br />

disease.<br />

diluted tea tree oil application<br />

for Demodex eradication (see Eye<br />

on Ophthalmology, overleaf), lid<br />

margin debridement to manage<br />

excess lid margin keratinisation<br />

and therapeutic gland expression<br />

to relieve meibomian gland<br />

blockage might also be considered.<br />

Eye care professionals are<br />

assuming greater responsibility<br />

than ever in addressing their<br />

patients’ needs through more<br />

targeted management of dry eye.<br />

Whether in a specialist practice<br />

offering a dedicated ‘Dry Eye<br />

Clinic’ or in a general practice,<br />

the commitment to following<br />

consensus recommendations<br />

in diagnosing and managing<br />

dry eye will offer consistency to<br />

patients and help advance our<br />

understanding of the disease. This,<br />

in turn, will improve the care we<br />

can offer to the increasing number<br />

of affected patients. Recognising<br />

risks and limitations in dry<br />

eye and ocular surface disease<br />

management, however, remains<br />

critical. Patients with significant<br />

corneal involvement continue to<br />

require ophthalmological review<br />

and those with a neuropathic<br />

component to their ocular surface<br />

condition might benefit from<br />

referral to a pain clinic for the most<br />

appropriate care, so having suitable<br />

referral options for particularly<br />

complex cases is advisable. <br />

Reference<br />

1. Wolffsohn JS et al. TFOS DEWS II Diagnostic<br />

Methodology report. Ocul Surf 2017; 15(3): 539-74.<br />

Associate Professor Jennifer Craig is<br />

head of the Ocular Surface Laboratory<br />

at the University of Auckland, vice-chair<br />

of TFOS DEWS II and clinical editor of NZ<br />

Optics’ annual special feature on dry eye.<br />

86%<br />

Treat<br />

MGD has been shown<br />

to affect 86% of<br />

patients with dry eye 1<br />

INDICATIONS FOR USE: The LipiFlow System is intended for the application of localized heat and pressure therapy in adult patients with chronic cystic conditions<br />

of the eyelids, including Meibomian Gland Dysfunction (MGD), also known as Evaporative Dry Eye or Lipid Deficiency Dry Eye. CONTRAINDICATIONS:<br />

Do not use the LipiFlow System in patients with the following conditions. Use of the device in patients with these conditions may cause injury. Safety and effectiveness<br />

of the device have not been studied in patients with these conditions.•Ocular surgery within prior 3 months, including intraocular, oculo-plastic, corneal or<br />

refractive surgery procedure•Ocular injury within prior 3 months Ocular herpes of eye or eyelid within prior 3 months•Active ocular infection (e.g., viral,<br />

bacterial, mycobacterial, protozoan, or fungal infection of the cornea, conjunctiva, lacrimal gland, lacrimal sac, or eyelids including a hordeolum or stye)•Active<br />

ocular inflammation or history of chronic, recurrent ocular inflammation within prior 3 months (e.g., retinitis, macular inflammation, choroiditis, uveitis, iritis, scleritis,<br />

episcleritis, keratitis)•Eyelid abnormalities that affect lid function (e.g., entropion, ectropion, tumor, edema, blepharospasm, lagophthalmos, severe trichiasis,<br />

severe ptosis)•Ocular surface abnormality that may compromise corneal integrity (e.g., prior chemical burn, recurrent corneal erosion, corneal epithelial<br />

defect, Grade 3 corneal fluorescein staining, or map dot fingerprint dystrophy) PRECAUTIONS: The Activator or Activator II (Disposable) may not fit all eyes,<br />

such as eyes with small palpebral fornices. Use of the LipiFlow System in patients with the following conditions may result in reduced treatment effectiveness<br />

because these conditions may cause ocular symptoms unrelated to cystic meibomian glands and require other medical management. Safety and effectiveness<br />

of the device have not been studied in patients with these conditions.•Moderate to severe (Grade 2-4) allergic, vernal or giant papillary conjunctivitis•Severe<br />

(Grade 3 or 4) eyelid inflammation(e.g., blepharochalasis, staphylococcal blepharitis or seborrheic blepharitis). Patients with severe eyelid inflammation should<br />

be treated medically prior to device use•Systemic disease conditions that cause dry eye(e.g., Stevens-Johnson syndrome, vitamin A deficiency, rheumatoid<br />

arthritis, Wegener’s granulomatosis, sarcoidosis, leukemia, Riley-Day syndrome, systemic lupus erythematosus, Sjögren’s syndrome)•Taking medications known<br />

to cause dryness (e.g., isotretinoin (Accutane ® ) and systemic antihistamines)•Esthetic eyelid and eyelash procedures (e.g., blepharoplasty, lash extensions,<br />

eyelid tattooing). In addition, the treatment procedure may loosen previously inserted punctal plugs, which may worsen the patient’s dry eye symptoms.<br />

Reference: 1. Lemp, M. A., Crews, L. A., Bron, A. J., Foulks, G. N., & Sullivan, B. D. (2012). Distribution of Aqueous-Deficient and Evaporative Dry Eye in a<br />

Clinic-Based Patient Cohort. Cornea, 31(5), 472-478. doi:10.1097/ico.0b013e318225415a. Australia: AMO Australia Pty Ltd, 1-5 Khartoum Road, North<br />

Ryde, NSW 2113, Australia. Phone: 1800 266 111. New Zealand: AMO Australia Pty. Ltd. 507 Mount Wellington Hwy, Mount Wellington, Auckland 1060,<br />

New Zealand. Phone: 0800 266 700.| PP<strong>2018</strong>TS4191<br />

WWW.EYEONOPTICS.CO.NZ | 41


DRY EYE <strong>2018</strong><br />

EYE ON OPHTHALMOLOGY<br />

FOR ALL EYE CARE PROFESSIONALS<br />

Antiparasitic efficacy of eyelid cleansers for<br />

the treatment of Demodex blepharitis<br />

By Dr Michael Wang and A/Prof Jennifer Craig<br />

Ocular surface infestation with Demodex<br />

mites is recognised as a significant risk factor<br />

for the development of chronic blepharitis 1 .<br />

Although 50% tea tree oil (Melaleuca<br />

alternifolia) is currently the mainstay for<br />

anti-demodectic treatment, it can cause<br />

considerable ocular irritation, restricting its<br />

use to brief in-office application 2 .<br />

This article briefly reviews the relationship<br />

between ocular Demodex and blepharitis,<br />

as well as two recent studies conducted by<br />

the University of Auckland Ocular Surface<br />

laboratory exploring the anti-demodectic<br />

efficacy of commercially-available eyelid<br />

cleansers and manuka honey 3,4 .<br />

Ocular Demodex and blepharitis<br />

Blepharitis is among the most commonly<br />

encountered ophthalmic conditions in<br />

clinical practice, affecting up to 47% of<br />

patients presenting to eye care practitioners.<br />

The condition is characterised by chronic<br />

inflammation of the eyelids and is recognised<br />

to have profound impacts on ocular comfort,<br />

vision and quality of life. It is commonly<br />

associated with signs and symptoms of<br />

ocular surface irritation, dry eye syndrome,<br />

intermittent visual disturbance, conjunctival<br />

hyperaemia, palpebral erythema and eyelid<br />

crusting. In severe cases, the inflammatory<br />

processes can also contribute to the<br />

development of irreversible sight-threatening<br />

corneal damage 5,6 .<br />

Although the complex pathophysiological<br />

mechanisms underlying the development of<br />

chronic blepharitis are not fully understood,<br />

Fig 1. Cylindrical collarettes suggestive of Demodex<br />

recent research would suggest that ocular<br />

infestation with Demodex might be an<br />

important cause. Indeed, ocular demodicosis is<br />

observed in up to 68% of patients with chronic<br />

blepharitis and 60% of those with meibomian<br />

gland dysfunction, the most common subtype of<br />

posterior blepharitis. Infestation with Demodex<br />

folliculorum and Demodex brevis species (Fig<br />

1), predominantly in the eyelash follicles and<br />

meibomian glands respectively, is thought to<br />

trigger an over-activation of host immune and<br />

inflammatory responses through a number of<br />

different mechanisms. Mechanical obstruction<br />

of the eyelash follicles and meibomian glands,<br />

as well as direct consumption and physical<br />

damage of the epithelium by the sharp<br />

appendages of the Demodex mites can directly<br />

induce inflammatory cascades. The associated<br />

reduction in the quality and quantity of<br />

meibomian gland secretions may also exacerbate<br />

aqueous tear evaporation, leading to tear film<br />

instability, hyperosmolarity, and ocular surface<br />

inflammation. In addition, chitin (the main<br />

constituent of the Demodex exoskeleton),<br />

as well as mite break-down products are<br />

strongly antigenic in some individuals. Finally,<br />

Demodex mites are also a potential vector<br />

for bacteria, especially Bacillus oleronius, and<br />

ocular infestation can contribute to bacterial<br />

hypercolonisation of the eyelids 7-9 .<br />

The diagnosis of ocular demodicosis is<br />

usually made clinically by the pathognomonic<br />

observation of cylindrical eyelash collarettes<br />

under slit lamp bio-microscopy (Fig 2), although<br />

the examination of epilated eyelashes for the<br />

presence of mites under light microscopy<br />

remains the gold standard diagnostic test.<br />

Treatment with 50% tea tree oil is the<br />

current mainstay for demodectic blepharitis<br />

management, although the considerable ocular<br />

irritation triggered by topical application limits<br />

its use to brief in-office application periods<br />

of less than 30 minutes. Self-administered<br />

eyelid cleansing formulations containing lower<br />

concentrations are usually recommended for<br />

patient use during intervening periods. The<br />

anti-demodectic efficacy of tea tree oil is thought<br />

to be primarily mediated by its terpinen-4-ol<br />

constituent, although the exact mechanisms by<br />

which inhibition of Demodex viability occurs<br />

has not yet been fully established 1,2,10-12 .<br />

Anti-demodectic efficacy of commercial<br />

eyelid cleansers<br />

A number of dedicated eyelid cleansing<br />

formulations are available commercially and<br />

are marketed to facilitate ocular hygiene<br />

in the management of chronic blepharitis.<br />

However, the antiparasitic efficacy of these<br />

topical formulations has not been previously<br />

established. A recent in vitro study conducted<br />

by the University of Auckland Ocular Surface<br />

Laboratory compared the anti-demodectic<br />

activity of four commercially available dedicated<br />

eyelid cleansers (Cliradex towelette cleanser,<br />

Oust Demodex cleanser, Blephadex eyelid<br />

foam and TheraTears SteriLid eyelid cleanser)<br />

with 50% tea tree oil. The study also sought to<br />

identify and quantify the active antiparasitic<br />

constituents of the commercial formulations 3 .<br />

Consistent with the results of earlier studies,<br />

potent antiparasitic activity of undiluted<br />

terpinen-4-ol was observed against ocular<br />

Demodex mites acquired from epilated eyelashes<br />

of blepharitis patients. Interestingly, linalool, a<br />

42 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


Professors Charles McGhee<br />

& Dipika Patel, series editors<br />

constituent of TheraTears SteriLid, was found to<br />

exhibit comparable anti-demodectic efficacy to<br />

terpinen-4-ol in its undiluted form. The specific<br />

antiparasitic activity of linalool against ocular<br />

Demodex has not been previously described<br />

in the literature and this novel finding would<br />

support future clinical studies exploring the<br />

efficacy of linalool-based formulations in the<br />

management of demodectic blepharitis.<br />

Although anti-demodectic activity was<br />

demonstrated by all four commercial eyelid<br />

cleansers, the Cliradex towelette cleanser<br />

was the only formulation that demonstrated<br />

comparable antiparasitic efficacy to 50% tea tree<br />

oil. This was thought to be potentially related to<br />

Cliradex containing the highest terpinen-4-ol<br />

content among the commercial formulations.<br />

Anti-demodectic efficacy of manuka<br />

honey<br />

Natural honey is well known for its antiinflammatory<br />

and antimicrobial capacities,<br />

which is likely attributed to its low pH, high<br />

Consistent with the results of earlier<br />

studies, potent antiparasitic activity<br />

of undiluted terpinen-4-ol was<br />

observed against ocular Demodex<br />

mites acquired from epilated<br />

eyelashes of blepharitis patients.<br />

osmolarity hydrogen peroxide content, and nonperoxide<br />

constituents, including methylglyoxal.<br />

New Zealand native manuka (Leptospermum<br />

scoparium) honey, in particular, has gained<br />

significant interest in recent years, due to its<br />

high concentrations of methylglyoxal, which is<br />

recognised to be more resistant to inactivation<br />

Fig 2. Adult Demodex brevis<br />

by heat and catalases then antimicrobial<br />

peroxide constituents. A cyclodextrincomplexed<br />

microemulsion formulation of MGO<br />

manuka honey has recently been developed<br />

for overnight topical eyelid application and is<br />

currently under investigation with regard to<br />

its to ocular hygiene potential in the clinical<br />

management of blepharitis. The eyelid cream<br />

has been observed to exhibit manuka honey<br />

in vitro anti-bacterial activity against ocular<br />

microbiota and successfully underwent<br />

safety and tolerability testing in a two-week<br />

randomised masked clinical trial of healthy<br />

human participants 13,14 .<br />

The in vitro anti-demodectic activity of<br />

MGO manuka honey was compared with<br />

50% tea tree oil in a recently published study<br />

conducted by the University of Auckland Ocular<br />

Surface Laboratory 4 . The findings demonstrated<br />

that cyclodextrin-complexed manuka honey<br />

exhibited comparable antiparasitic efficacy to<br />

50% tea tree oil against ocular Demodex mites<br />

acquired from blepharitis<br />

patients. Together with the<br />

results from the earlier clinical<br />

tolerability trial, this would<br />

suggest that manuka honey<br />

shows the potential to offer<br />

an alternative non-irritating<br />

topical treatment to 50% tea<br />

tree oil. Clinical trials exploring<br />

the efficacy of manuka honey<br />

in demodectic and nondemodectic<br />

blepharitis are<br />

already underway.<br />

Conclusions<br />

Ocular surface infestation with<br />

Demodex mites is emerging as a<br />

significant cause of chronic blepharitis. Topical<br />

50% tea tree oil formulations are the current<br />

mainstay of treatment for demodectic blepharitis,<br />

although the significant ocular irritation restricts<br />

its use to brief application periods under<br />

clinical supervision. A recent study conducted<br />

by the University of Auckland Ocular Surface<br />

Laboratory demonstrated antiparasitic activity<br />

of four commercially available, dedicated eyelid<br />

cleansers, although among the formulations<br />

tested, only Cliradex exhibited comparable<br />

efficacy to 50% tea tree oil. A separate study<br />

showed that comparable anti-demodectic<br />

activity was observed between MGO manuka<br />

honey and 50% tea tree oil, which would suggest<br />

promise for complexed manuka honey to offer<br />

an alternative non-irritating topical treatment for<br />

ocular Demodex infestation. <br />

References<br />

1. Nicholls SG, Oakley CL, Tan A, Vote BJ. Demodex species in human<br />

ocular disease: new clinicopathological aspects. Int Ophthalmol.<br />

2017;37(1):303-312.<br />

2. Koo H, Kim TH, Kim KW, Wee SW, Chun YS, Kim JC. Ocular Surface<br />

Discomfort and Demodex: Effect of Tea Tree Oil Eyelid Scrub in Demodex<br />

Blepharitis. J Korean Med Sci. 2012;27(12):1574-1579.<br />

3. Cheung IMY, Xue AL, Kim A, Ammundsen K, Wang MTM, Craig JP.<br />

In vitro anti-demodectic effects and terpinen-4-ol content of commercial<br />

eyelid cleansers. Contact Lens Anterior Eye. <strong>2018</strong> (in press).<br />

4. Frame K, Cheung IMY, Wang MTM, Turnbull PR, Watters GA, Craig JP.<br />

Comparing the in vitro effects of MGO Manuka honey and tea tree oil on<br />

ocular Demodex viability. Contact Lens Anterior Eye. <strong>2018</strong> (in press).<br />

5. Duncan K, Jeng BH. Medical management of blepharitis. Curr Opin<br />

Ophthalmol. Jul 2015;26(4):289-294.<br />

6. Sung J, Wang MTM, Lee SH, Cheung IMY, Ismail S, Sherwin T, Craig<br />

JP. Randomized double-masked trial of eyelid cleansing treatments for<br />

blepharitis. Ocul Surf. <strong>2018</strong>;16(1):77-83.<br />

7. Liu J, Sheha H, Tseng SCG. Pathogenic role of Demodex mites in<br />

blepharitis. Curr Opin Allergy Cl. 2010;10(5):505-510.<br />

8. English FP, Nutting WB. Feeding characteristics in demodectic mites of the<br />

eyelid Aust J Opthalmol. 1981;9(4):311-313.<br />

9. Kim JH, Chun YS, Kim JC. Clinical and Immunological Responses in<br />

Ocular Demodecosis. J Korean Med Sci. 2011;26(9):1231-1237.<br />

10. Gao YY, Di Pascuale MA, Li W, et al. In vitro and in vivo killing of ocular<br />

Demodex by tea tree oil. Br J Ophthalmol. 2005;89(11):1468-1473.<br />

11. Gao Y-Y, Di Pascuale MA, Elizondo A, Tseng SCG. Clinical Treatment<br />

of Ocular Demodecosis by Lid Scrub With Tea Tree Oil. Cornea.<br />

2007;26(2):136-143.<br />

12. Kheirkhah A, Casas V, Li W, Raju VK, Tseng SC. Corneal manifestations<br />

of ocular demodex infestation. Am J Opthalmol. 2007;143(5):743-749.<br />

13. Craig JP, Rupenthal ID, Seyfoddin A, Cheung IMY, Uy B, Wang MTM,<br />

Watters GA, Swift S. Preclinical development of MGO Manuka Honey<br />

microemulsion for blepharitis management. BMJ Open Ophthalmol.<br />

2017;1(1):e000065.<br />

14. Craig JP, Wang MTM, Ganesalingam K, Rupenthal ID, Swift S, Loh CS,<br />

Te Weehi L, Cheung IMY, Watters GA. Randomised masked trial of the<br />

clinical safety and tolerability of MGO Manuka Honey eye cream for the<br />

management of blepharitis. BMJ Open Ophthalmol. 2017;1(1):e000066.<br />

Dr Michael Wang is a part-time<br />

PhD student in the Department<br />

of Ophthalmology at the<br />

University of Auckland, under<br />

the supervision of A/Prof<br />

Jennifer Craig.<br />

WWW.EYEONOPTICS.CO.NZ | 43


NEWS<br />

Personalising glaucoma<br />

By Lesley Springall<br />

PERSONALISED MEDICINE, MOVING away from a one-size-fits-all<br />

approach, is a big thing in today’s British National Health Service and<br />

this can make a big difference for glaucoma patients, said Professor Keith<br />

Martin, head of ophthalmology at the University of Cambridge.<br />

Speaking at Allergan’s Beyond glaucoma meeting in Sydney in July, Prof<br />

Martin, the meeting’s keynote speaker, said primary open-angle glaucoma<br />

(POAG) tends to be considered as one disease with one treatment path -<br />

lowering intraocular pressure (IOP) - despite patients being very different<br />

and having a range of other conditions.<br />

“If you look at what’s happened in other areas of medicine in recent<br />

years, they have been revolutionised by their ability to diagnose specific<br />

variants of their disease more accurately.” This is particularly true for breast<br />

cancer, with every UK patient now molecularly phenotyped and their<br />

treatment plan designed to fit to their specific form of breast cancer.<br />

Driving this personalisation are advancements in understanding our<br />

own genomes and technology innovations. Technologies like the Sensimed<br />

Triggerfish contact lens sensor which can detect IOP-related changes over<br />

a 24-hour period, may help provide a better understanding of a patient’s<br />

glaucoma: slow versus fast progression or stable ocular hypertension<br />

versus ocular hypertension converting to glaucoma, said Prof Martin.<br />

“Health systems and health providers are now looking at ways to integrate<br />

this knowledge into patient care… to help us predict risk for diseases like<br />

glaucoma; who’s going to do well and who’s going to do badly and so will<br />

need more resources devoted to them.”<br />

Within glaucoma there’s been a plethora of innovations in recent years,<br />

such as minimally invasive glaucoma surgery (MIGS) and Allergan’s<br />

Xen Gel stent. But that makes it even more important to work out which<br />

treatment is the best for each, individual patient, he said. “Because none of<br />

these treatments are right for everyone.”<br />

At Cambridge, Prof Martin and his team are conducting a number of<br />

different studies looking at new, more personalised treatments for glaucoma<br />

patients, including stem cell research and other cell therapies. These have<br />

been shown to work in animal models but, as yet, there’s been no real<br />

clinical evidence. More worrying, he said, are the complications shown by<br />

patients who have had unsanctioned stem cell treatments off-shore, such as<br />

severe retinal scarring.<br />

Advancements in gene therapy are showing particular promise for<br />

eye diseases, said Prof Martin, highlighting a number of ongoing clinical<br />

studies. “The main problem is you’re limited in the amount of information<br />

Professor Keith Martin from Cambridge University presenting at Allergan’s Beyond glaucoma<br />

meeting in Sydney<br />

you can send into cells by the virus (gene carrier). Instead of a long email,<br />

it’s more like a tweet. So, you can only deliver limited instructions into the<br />

cell.”<br />

Prof Martin and his team have the go-ahead and the funding to<br />

sequence the whole genome of up to 60,000 patients a year with glaucoma,<br />

macular degeneration and diabetic retinopathy in the UK. “Whole genome<br />

sequencing on that number of patients is mind blowing in terms of the<br />

amount of data that will be generated, but also a huge opportunity.”<br />

While we wait for the results of these studies and other gene therapy<br />

clinical trials to come to fruition (and the cost of gene therapies to come<br />

down) we can still improve care for our glaucoma patients today, by better<br />

individualising care to maximse the benefits of both the new and older<br />

glaucoma treatments currently available, said Prof Martin. “This is where<br />

we get to become doctors again, to actually understand what our patients’<br />

needs are, what their fears are, and to help them weigh up the risks and the<br />

benefits of different treatments and make sensible decisions.”<br />

Allergan’s Beyond glaucoma meeting ran concurrently with its sister<br />

meeting, Beyond the retina, focusing on diabetic macular oedema (DMO).<br />

The two events were designed to talk about current and future treatments<br />

for glaucoma and DMO and introduce Allergan’s Xen Gel stent, a surgical<br />

implant designed to lower eye pressure in open-angle glaucoma patients,<br />

and Ozurdex, a sustained-release dexamethasone intravitreal implant,<br />

designed to treat DMO, to the Australia market. Both products were<br />

introduced to New Zealand at the end of last year. For more on both, search<br />

“Xen” or “Ozurdex” on www.eyeonoptics.co.nz <br />

RANZCO’s golden jubilee<br />

THE ROYAL AUSTRALIAN and New Zealand College of Ophthalmology’s<br />

(RANZCO’s) 50th Annual Scientific Congress, and associated parallel<br />

conferences for Australasian ophthalmic nurses and practice managers,<br />

will take place at the Adelaide Convention Centre from 17-21 November.<br />

The Scientific Congress will feature a range of eminent international<br />

and local speakers including Profs Robyn Guymer, Giovanni Staurenghi<br />

and Stephanie Watson, A/Prof Angus Turner and Drs Marlene Moster,<br />

Ramin Salouti, Russell Van Gelder and Bradley Randleman. Convenor<br />

Dr Neil Gehling promises an exceptional programme with thoughtprovoking<br />

presentations, interactive workshops and distinguished<br />

keynote addresses.<br />

The practice manager’s conference will focus on different<br />

management aspects, including bench marking, social media<br />

security and environmental sustainability, and features more than 20<br />

presentations from specialist speakers and leaders within their fields.<br />

The ophthalmic nurses’ Pacific Rim Conference, will be held on<br />

Sunday 18 November and includes speakers such as: Elethia Dean, a USregistered<br />

nurse with specialist experience in clinical and administrative<br />

care in acute and ambulatory settings; and New Zealand’s David Garland,<br />

an ophthalmic nurse practitioner with more than 15 years’ experience in<br />

ophthalmology.<br />

Visitors will have ample opportunity to savour Adelaide’s renowned<br />

local wines and cuisine in the Congress centre precinct as well as in<br />

nearby Adelaide Hills, McLaren Vale and Barossa Valley. This year’s social<br />

programme also includes the opportunity to visit local treasures such as<br />

Adelaide Zoo, venue for the <strong>2018</strong> welcome reception, and the Adelaide<br />

Oval, which will host the congress dinner.<br />

RANZCO early bird rates close 12 <strong>Sep</strong>tember <strong>2018</strong>. For more and to<br />

register, please visit www.ranzco<strong>2018</strong>.com or www.aonavic.com.au<br />

44 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


ONZ Update<br />

By the ONZ Board<br />

OPHTHALMOLOGY NEW ZEALAND (ONZ) has had a busy start to the<br />

year, working behind the scenes on the introduction of minimally-invasive<br />

glaucoma surgery (MIGS) and devices into private ophthalmology and<br />

member queries.<br />

The annual Royal Australia and New Zealand College of Ophthalmology<br />

(RANZCO) NZ Branch meeting, held this year at the Hilton in Auckland,<br />

was another great opportunity for New Zealand ophthalmologists to meet<br />

the board members of ONZ, to hear the issues members face and to let those<br />

members know about the work that goes on behind the scenes by ONZ.<br />

The ONZ board consists of six members: Drs Michael Merriman, Kevin<br />

Taylor, Peter Hadden, Rebecca Stack, Dean Corbett and Shenton Chew, who<br />

all work tirelessly and voluntarily on the issues that are outside RANZCO’s<br />

normal remit. ONZ also works closely on a number of issues with RANZCO<br />

as many of our board members are also on committees and in advisorial<br />

roles with RANZCO.<br />

The key issues ONZ acts on range from commercial insurance matters<br />

to how to serve the ophthalmologists and their patients better. Of necessity,<br />

many of our discussions are around insurance relationships... but more about<br />

that later.<br />

Regarding representing and supporting our members, we now have two<br />

key events as part of our members’ calendar: our Clinical Leaders Forum,<br />

facilitated by Dr Rebecca Stack; and our Business Forum.<br />

Our Clinical Leaders Forum was held in Wellington in March and<br />

covered updates from the EAG (expert advisory group), RANZCO, the<br />

Ministry of Health and Health Workforce New Zealand and reviewed the<br />

new glaucoma and macular degeneration guidelines and RANZCO’s work<br />

on managing poorly-performing doctors (see p10).<br />

ONZ Business Forum – The Other Matters<br />

It was pleasing to see a good turnout at this year’s Business Forum, The Other<br />

Matters, despite the difficult timing around the RANZCO NZ meeting. We<br />

would like to thank our sponsors for their support of this event, especially<br />

Legacy Insurance for supporting our welcome drinks. It was great to relax<br />

together at the Hilton Bar.<br />

Despite the time restrictions, we still managed to cover a number of<br />

important topics at this year’s Business Forum including the legal structuring<br />

of our businesses, risk, engaging staff and ONZ strategy, plus an interesting<br />

presentation from Dr Stephen Childs, Southern Cross Healthcare’s chief<br />

medical officer.<br />

Feedback on both the Clinical and Business Forum events was positive<br />

and helps us to format a needs-based agenda for the next Forums.<br />

Insurance relationships<br />

It is no surprise to NZ Optics readers that costs in health care are rising<br />

and that providers have been forced to shoulder the burden of these costs<br />

to ensure a healthy public and private sector. There are many publications<br />

discussing the underlying factors in current and projected cost rises, but<br />

these are mainly due to an aging demographic needing more care; increasing<br />

life expectancies; rising costs in technology and aids; and the rising cost of<br />

pharmaceuticals.<br />

As these costs impact on the private health insurance industry bodies,<br />

and they struggle to maintain their funds, pressure is brought to bear on<br />

providers to shoulder the increased costs. ONZ seeks to support its members<br />

whilst ensuring a fair and transparent playing field for members, insurers<br />

and consumers of health care. Thus, we are working with insurance bodies to<br />

form robust relationships and provide consultation on clinical matters. We<br />

also made a recent submission to the Insurance Contracts Review, conducted<br />

by the MBIE, highlighting the need for reform in New Zealand Health<br />

Insurance law and identifying strategies used in other jurisdictions.<br />

ONZ also pointed out the perils of obscuring the rising costs in health<br />

care, encouraging a system which improves transparency and choice for<br />

private health consumers while limiting cost shifting to providers. If we<br />

cannot limit this shift to providers, it will become increasingly unattractive<br />

for providers to go into private care and the burden shifts to the public<br />

system. <br />

FULLY<br />

FUNDED<br />

FROM 1 JUNE <strong>2018</strong><br />

in both the community<br />

and hospital settings 1<br />

EYLEA is fully funded under Special Authority and Restricted criteria for<br />

Wet Age Related Macular Degeneration and Diabetic Macular Oedema. 1<br />

For information on the full reimbursement criteria view the Pharmac<br />

notification at www.pharmac.govt.nz 1<br />

Reference: 1. PHARMAC website www.pharmac.govt.nz accessed 13/6/<strong>2018</strong>.<br />

EYLEA® (aflibercept) EYLEA is used in ophthalmology. Prescription medicine. 40 mg/mL solution for<br />

intravitreal injection containing aflibercept. INDICATIONS: EYLEA (aflibercept) is indicated in adults for the<br />

treatment of neovascular (wet) age-related macular degeneration (wet AMD), visual impairment due to macular<br />

oedema secondary to central retinal vein occlusion (CRVO), visual impairment due to macular oedema secondary<br />

to branch retinal vein occlusion (BRVO), diabetic macular oedema (DME), visual impairment due to myopic<br />

choroidal neovascularisation (myopic CNV). DOSAGE REGIMEN AND ADMINISTRATION: 2 mg aflibercept<br />

(equivalent to injection volume of 50 μL). The interval between doses injected into the same eye should not<br />

be shorter than one month. Once optimal visual acuity is achieved and/or there are no signs of disease activity,<br />

treatment may then be continued with a treat-and-extend regimen with gradually increased treatment intervals<br />

to maintain stable visual and/or anatomic outcomes. If disease activity persists or recurs, the treatment<br />

interval may be shortened accordingly. Monitoring should be done at injection visits. There is limited information<br />

on the optimal dosing interval and monitoring interval especially for long-term (e.g. > 12 months) treatment.<br />

The monitoring and treatment schedule should be determined by the treating ophthalmologist based on the<br />

individual patient’s response. If visual and anatomic outcomes indicate that the patient is not benefiting from<br />

continued treatment, EYLEA should be discontinued. For wet AMD: Treatment is initiated with one intravitreal<br />

injection per month for three consecutive months, followed by one injection every two months. Long term, it<br />

is recommended to continue EYLEA every 2 months. Generally, once optimal visual acuity is achieved and/or<br />

there are no signs of disease activity, the treatment interval may be adjusted based on visual and/or anatomic<br />

outcomes. The dosing interval can be extended up to every 3 months. For CRVO: Treatment is initiated with<br />

one injection per month for three consecutive months. After the first three monthly injections, the treatment<br />

interval may be adjusted based on visual and/or anatomic outcomes. For BRVO: Treatment is initiated with one<br />

injection per month for three consecutive months. After the first three monthly injections, the treatment interval<br />

may be adjusted based on visual and/or anatomic outcomes. For DME: Treatment is initiated with one injection<br />

per month for five consecutive months, followed by one injection every two months. After the first 12 months,<br />

the treatment interval may be adjusted based on visual and/or anatomic outcomes. For myopic CNV: EYLEA<br />

treatment is initiated with one injection of 2 mg aflibercept (equivalent to 50 μL). Additional doses should be<br />

administered only if visual and/or anatomic outcomes indicate that the disease persists. Recurrences are treated<br />

like a new manifestation of the disease. CONTRAINDICATIONS: Known hypersensitivity to aflibercept or excipients;<br />

ocular or periocular infection; active severe intraocular inflammation. PRECAUTIONS: Endophthalmitis, increase<br />

in intraocular pressure; immunogenicity; arterial thromboembolic events; bilateral treatment; risk factors for<br />

retinal pigment epithelial tears; treatment should be withheld in case of rhegmatogenous retinal detachment,<br />

stage 3 or 4 macular holes, retinal break, decrease in best-corrected visual acuity of ≥ 30 letters, subretinal<br />

haemorrhage or intraocular surgery; treatment not recommended in patients with irreversible ischemic visual<br />

function loss; population with limited data (diabetic macular oedema due to type 1 diabetes, diabetic patients<br />

with HbA1c > 12 %, proliferative diabetic retinopathy, active systemic infections, concurrent eye conditions,<br />

uncontrolled hypertension, myopic CNV: no experience in the treatment of non-Asian patients, previous treatment<br />

for myopic CNV and extrafoveal lesions), see full Data Sheet for effects on fertility, pregnancy, lactation, effects<br />

on ability to drive or use machines. INTERACTIONS: No formal drug interaction studies have been performed.<br />

ADVERSE EFFECTS: Very common: conjunctival haemorrhage, visual acuity reduced, eye pain. Common: retinal<br />

pigment epithelial tear, detachment of retinal pigment epithelium, retinal degeneration, vitreous haemorrhage,<br />

cataract, cataract cortical, cataract nuclear, cataract subcapsular, corneal erosion, corneal abrasion, intraocular<br />

pressure increased, vision blurred, vitreous floaters, vitreous detachment, injection site pain, foreign body<br />

sensation in eyes, lacrimation increased, eyelid oedema, injection site haemorrhage, punctate keratitis,<br />

conjunctival hyperaemia, ocular hyperaemia. Serious: endophthalmitis, retinal detachment, cataract traumatic,<br />

cataract, vitreous detachment, intraocular pressure increased, arterial thromboembolic events, hypersensitivity<br />

including isolated cases of severe anaphylactic/anaphylactoid reactions. Others:<br />

see full Data Sheet. Based on DS: Dated 31 May 2016. Eylea is fully funded from<br />

1 June <strong>2018</strong>. A prescription fee will apply. This medicine has risks and benefits.<br />

Before prescribing, please review Data Sheet for further information on the risks<br />

and benefits. Full Data Sheet is available from www.medsafe.govt.nz or Bayer<br />

New Zealand Limited, 3 Argus Place, Hillcrest, Auckland 0627. Telephone<br />

0800 233 988. BY8749 Approval number NZ-EYL-00012-08-<strong>2018</strong> NA10154<br />

Prepared July <strong>2018</strong>. ® Registered trademark of the Bayer Group, Germany<br />

WWW.EYEONOPTICS.CO.NZ | 45


BUSINESS<br />

FOCUS ON BUSINESS SPONSORED BY<br />

THE INDEPENDENT<br />

OPTOMETRY GROUP<br />

Practice intelligence: What gets measured, gets done<br />

By Robert Springer<br />

TODAY’S PRACTICE OWNER has access to<br />

more information and insights into how the<br />

practice is performing than ever before. With a<br />

focused approach, you will be able to monitor<br />

key metrics delivering improved results.<br />

In our daily interactions with practice<br />

owners, we find that the most important term to<br />

be familiar with is “conversions”. A conversion<br />

is simply the successful result of a patient<br />

responding to your message with the desired<br />

outcome - a booked appointment, a practice<br />

visit, a purchase or a positive word-of-mouth<br />

testimonial.<br />

In the past, conversion tracking was an<br />

expensive exercise and tracking tools were<br />

not well integrated into practice management<br />

systems, often resulting in information gaps. Did<br />

the patient book an appointment? Did the patient<br />

buy something? If you can’t measure it, you are<br />

missing out on very valuable information which<br />

can help shape your future activities.<br />

Conversion measurement can be applied<br />

across all facets of practice management. Here<br />

are some of the more important ones:<br />

Recalls<br />

The most important conversion tracking is<br />

your recall process, which is usually entrenched<br />

within your practice management system.<br />

Although you can view recall statistics over<br />

a longer period of time, we recommend<br />

monitoring recall effectiveness at 90 days.<br />

Beyond this, there is an increasing probability<br />

the patient may find an interim eye care solution<br />

elsewhere. Recall rates can be split by phone,<br />

SMS or email, and you can use a combination to<br />

increase response effectiveness.<br />

Website<br />

You may already be familiar with Google<br />

Analytics as the most common way to track<br />

the performance of your website. An example<br />

of conversion tracking is to identify how many<br />

visitors click your “Request an appointment”<br />

button or web form. There are other website<br />

plugins that sync with your marketing list to<br />

reveal who within your database is viewing your<br />

webpage and how long they are engaged with<br />

reading your content.<br />

Social media<br />

Facebook is a viable way to generate new<br />

appointments and to showcase all the great<br />

things that you do in practice. Likes, shares<br />

and comments are all the visible ways you can<br />

monitor activity on your page, but this represents<br />

only a very small portion of people who are<br />

viewing your posts. Installing the Facebook Pixel,<br />

a tracking code, on your website will allow you to<br />

track conversions from Facebook to your website<br />

and through to online booking.<br />

Email newsletters<br />

Sending occasional email communications to<br />

your database can be an effective way to keep<br />

patients informed of your latest offers, campaign<br />

messages or promotions. Email is a way to<br />

create a digital on-going connection with your<br />

patients, which also brings additional insights<br />

because you can track what patients are viewing<br />

on your website after they click from the email.<br />

Promotional campaigns<br />

You have a message you want everyone to know<br />

about? Be sure to include a measurable call-toaction.<br />

SMS campaigns should use clickable<br />

links to capture who has shown interest to read<br />

more. Alternatively, you can use two-way SMS,<br />

asking the patient to reply via SMS in response<br />

to a yes/no question. Printed letters should<br />

include a call-to-action which uses a specific<br />

campaign phone number or a webpage that is<br />

unique to the message you are promoting so<br />

you can get some idea about patient response.<br />

Remember to ensure you have patient<br />

permissions in place before contacting them<br />

with any SMS or email promotions, however.<br />

How can you increase “conversions”?<br />

1. Reduce the points of friction - Put yourself<br />

in the shoes of your patient. How can you make<br />

the booking and eye care process as easy as<br />

possible? Which technology systems will you<br />

offer to appeal to your target audience: online<br />

self-booking appointments, pre-appointing<br />

with SMS reminders, Facebook Messenger,<br />

personalised letters, phone calls from your<br />

staff… all of these can make it easier for<br />

patients, so chose the technology stack that’s<br />

right for your practice.<br />

2. A/B message testing - How do you know<br />

if your message will be effective? You need to<br />

test it! Put simply, an A/B Test is running two<br />

simultaneous versions of a message to see which<br />

one gets the better response. Use the one that<br />

gets greater conversions more often!<br />

Ensure that everything you do can be<br />

measured and create a simple monthly<br />

dashboard for yourself which includes the areas<br />

you are actively investing time and money into.<br />

Every successful conversion will reinforce that<br />

you have a process that works and will build<br />

your confidence in taking proactive steps to<br />

grow your practice successfully. <br />

Robert Springer is<br />

the technical director<br />

of OptomEDGE, an optometryfocused<br />

marketing agency<br />

covering campaigns, printed<br />

and digital recalls and patient<br />

communications. To learn more,<br />

please call +64 9 889 3179 or<br />

email ask@optomedge.co.nz<br />

The Independent Optometry Group, providing the advice<br />

and service independents need to thrive.<br />

To find out more contact Neil Human on 0210 292 8683<br />

or neil.human@iogroup.co.nz<br />

46 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


NEWS<br />

Jono: time for design<br />

By Lesley Springall<br />

AUSTRALIAN EYEWEAR<br />

DESIGNER Jono Hennessy Sceats,<br />

creator of popular Australasian<br />

brands, Jono Hennessy, Carter<br />

Bond and Zeffer, says the best<br />

thing about joining international<br />

Australasian eyewear distributor<br />

Sunshades is he can get back to<br />

doing what he loves best - design.<br />

“We built an international<br />

company. We now sell 40% of<br />

our frames in Europe, but there<br />

were only four of us running the<br />

business. It got too hard… we<br />

needed help… we were spending<br />

too much time on administration<br />

and not enough time on the<br />

product.”<br />

So, it was exciting, he says,<br />

when Sunshades CEO Rodney<br />

Grunseit, son of Sunshades<br />

founder Bette Lasse, approached<br />

him and his business partner wife,<br />

Louise Sceats, 10 months ago<br />

with a business proposition to do<br />

something special together.<br />

Becoming part of Sunshades<br />

Eyewear business is the<br />

culmination of a personal and<br />

professional friendship first formed<br />

more than 30 years ago, says Jono.<br />

“Betty Lasse was my first account<br />

and she was so supportive and<br />

wonderful. My designs at the time<br />

were a totally new look and not<br />

getting great interest. Betty then<br />

sold them well and Vogue did a<br />

story, so it was all then accepted.”<br />

Even when the businesses were<br />

no longer connected, Jono was still<br />

welcome on Betty’s guest list, he<br />

says. “She was a very special person<br />

and I am grateful for her uplifting<br />

support. Today I see the same<br />

feelings surrounding the team<br />

at Sunshades, including her son<br />

Rodney who continues her legacy<br />

so proudly.”<br />

The decision to join Sunshades<br />

makes sense given the increasingly<br />

competitive nature of eyewear<br />

today, says Jono, as it allows him<br />

and Louise to concentrate on<br />

design while still being part of a<br />

family-run company, harnessing its<br />

larger distribution and back-end<br />

support infrastructure. “Sunshades<br />

is a design-led company. They<br />

export brands across the world<br />

from New Zealand and Australia,<br />

Jono Hennessy Sceats (left) with Sunshades’ Anthony Whittle and Alyssa Piva, and Louise Sceats,<br />

Kerry Carey and Jesse Nel<br />

brands like Karen Walker, its<br />

extraordinary and something to be<br />

proud of.”<br />

Being design-led is vital for<br />

businesses in Australia and<br />

New Zealand, he adds, because<br />

companies here can’t compete on<br />

price.<br />

With his newest accolade being<br />

made a member of the Design<br />

Institute of Australia’s Hall of Fame,<br />

Jono says he hopes to influence<br />

the Australian government to<br />

rank design more highly within its<br />

research and development business<br />

grants. But that’s a little way down<br />

the track.<br />

First, he’s getting back to<br />

basics with his eyewear brands,<br />

he says, researching and working<br />

new materials to provide the<br />

most comfortable fit, while still<br />

maintaining the style his brands<br />

have become known for.<br />

Without giving too much<br />

away, Jono says his current design<br />

influences include original wire<br />

frames made in China in the 1880s<br />

to 1890s, Japanese construction<br />

and car paint colours. Sounds like<br />

fun? “Yes, yes it is,” he says with a<br />

smile. <br />

Welcome to OSO18<br />

The 13th Congress of the<br />

Orthokeratology Society of Oceania,<br />

OSO18, will run from 5-7 October<br />

at the Royal Pines Resort on<br />

Queensland’s Gold Coast.<br />

The conference will feature some<br />

of the best practitioners and<br />

researchers in the world discussing<br />

the latest in ortho-k lens design and<br />

research, said Gavin Boneham, OSO<br />

president. “The programme has a<br />

strong focus on myopia control and<br />

will offer something for everyone<br />

who is, or wants to be, involved in<br />

the stimulating field of ortho-k and<br />

myopia control.”<br />

As well as lectures, the programme<br />

includes workshops on ortho-k,<br />

specialty lens fitting and advanced<br />

topography, with a special practical<br />

session on Sunday morning on how<br />

to set up and run a myopia control<br />

practice. International keynote is<br />

acclaimed Professor Earl Smith,<br />

College of Optometry dean at the<br />

University of Houston, who received<br />

the Glenn Fry Award and the<br />

Prentice Medal from the American<br />

Academy of Optometry for his<br />

research on the role of vision in<br />

regulating refractive development<br />

and eye growth.<br />

The popular “Meet the Speakers”<br />

Friday night drink is back,<br />

complementing the ‘world famous’<br />

themed gala dinner party on<br />

Saturday evening. To register, visit:<br />

www.oso.net.au/whats-on <br />

WWW.EYEONOPTICS.CO.NZ | 47


NEWS<br />

Most creative dress award went to Alice Jackson, Marna Claassen, Paddy Perrett and Lauren Curd<br />

EyeBall’s island<br />

of vision<br />

By Aimee Aitken, NZOSS executive team<br />

The fabulous SOVS staff: Bhav Solanki, Zaria Bradley, Jean Choi, Kristine Hammond,<br />

Alyssa Lie, Adina Giurgiu, Kathryn Sands, Zoe Smith and Lisa Silva<br />

DESPITE THE CHILLY winter weather, the atmosphere was warm at<br />

the Grand Millennium at the end of July as the University of Auckland’s<br />

School of Optometry and Vision Science celebrated their annual EyeBall,<br />

themed Utropia: Welcome to the Island of Vision!<br />

The evening was a success and thoroughly enjoyed by more than 200<br />

students, staff and sponsors, all of whom were dressed impeccably. An<br />

impressive number of guests dressed to the island theme, with prizes<br />

awarded for both Best dressed (Robert Burnie) and Most creative (Alice<br />

Jackson, Marna Claassen, Paddy Perrett and Lauren Curd). The Ball<br />

Committee was certainly faced with a difficult decision to determine the<br />

winners!<br />

The EyeBall is the most anticipated social event of the year for<br />

optometry students and staff at the university, and it would not be such<br />

an amazing night without the help of our generous sponsors: Specsavers,<br />

Eye Institute, OPSM, Essilor, NZAO, CooperVision, Designs for Vision,<br />

Optimed, Eyeline Optical and NZOSS. Thank you all!<br />

The Ball Committee also deserves thanks for all their hard work: Anna<br />

Chen, Mary Rush, Nileesha Parbhu and Maggie Xu, plus we’d like to say a<br />

special thank you to Muthana Noori for being a talented MC on the night<br />

and to the Red Frogs University support volunteers for all their help. We’re<br />

already waiting in anticipation for the 2019 EyeBall and can’t wait to see<br />

what the next committee comes up with! <br />

For more from SOVS, see p16<br />

Jason Kumar, Nadiah Madahi, Sushmita Chinchankar, Hannah Pike, Anna-Marie Rohs,<br />

and Amosa Lene at the EyeBall<br />

Part III students enjoying the EyeBall<br />

Photos courtesy of Alethea Lim.<br />

48 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


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WWW.EYEONOPTICS.CO.NZ | 49


NEWS<br />

Winter warmth at the O-Show<br />

By Lesley Springall<br />

Eyes Right and Modstyle’s Lisa and Mark Wymond<br />

OptiMed’s Craig Norman and the new Thermaeye<br />

50 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong><br />

STEPPING INTO THE darkened hall of the<br />

biennial O-Show, again held at Central Pier in<br />

Melbourne’s Docklands, is like stepping into a<br />

cocoon of warm hospitality.<br />

The larger exhibition halls of other<br />

conferences and fairs are a far cry from<br />

this boutique offering from the Optical<br />

Manufacturing Association of Australia<br />

(ODMA). There’s no CPD-session pressure to<br />

see exhibitors at certain times, allowing for a<br />

leisurely flow of visitors throughout the show’s<br />

two days.<br />

Exhibitor space at this year’s O-Show sold<br />

Clic’s Helen Najar (right)<br />

Eyepro’s Tom Frowde and Chris Clark<br />

out quickly to many of the region’s biggest<br />

frames and equipment suppliers. The <strong>2018</strong><br />

event also attracted more than 700 visitors; the<br />

majority from Victoria, but nearly a quarter<br />

from elsewhere in Australia and overseas,<br />

including New Zealand.<br />

Matt Wensor, Zeiss Australasia’s strategic<br />

marketing manager, said ODMA members<br />

didn’t just support the event because they were<br />

ODMA members, but because the event works.<br />

“The O-Show has a smaller boutique feel about<br />

it, which creates a good opportunity to catch up<br />

with customers and others within the industry<br />

in a relaxed and unhurried environment.”<br />

Eyes Right Optical’s new managing director<br />

Mark Wymond, son of founders Gaye and<br />

David Wymond, also commented on the show’s<br />

relaxed feel, allowing exhibitors to catch up with<br />

a lot of people in just a couple of days.<br />

Popular Australian eyewear designer Jono<br />

Hennessy Sceats is another fan, saying he’d be<br />

happy to attend O-Shows annually in different<br />

centres if ODMA decided to run them. “Other<br />

exhibitions have become too expensive,<br />

too commercial, while the O-Show is more<br />

personable. It’s like having a chat with someone<br />

at your house; there’s no pressure to spend<br />

$50,000 on doing your stand.”<br />

As well as the exhibition, this year’s O-Show<br />

included informal presentations from David<br />

Inderias from Techprint on his 3D-printed<br />

eyewear; Yvette Wadell, the newly appointed<br />

CEO of Brien Holden Vision Institute, on the<br />

myopia epidemic; and Vivienne Forbes from<br />

Social Ties, who provided some social media<br />

tips and tricks. Retail stylist, Kerry van Beuge,<br />

once again filled out her slots for her lowcost<br />

window display tips, while the Saturday<br />

evening’s cocktail party appeared to increase<br />

visitor numbers several-fold.


O-Show news<br />

There was also a good deal of news on offer with<br />

several companies introducing new products to<br />

the market. News highlights included:<br />

• OptiMed’s Thermawave – the latest offering<br />

in the intense pulsed light (IPL) equipment<br />

battle, Thermawave was developed by<br />

ophthalmologists in Spain, requiring no filters<br />

and no additional cooling systems; simple<br />

to use; and targeted to help patients with<br />

meibomian gland dysfunction, conjunctivitis,<br />

blepharitis and Demodex infection*<br />

• Clic brochure and Manhattan – Clic<br />

has launched a detailed brochure for eye<br />

professionals to discuss different styles with their<br />

patients. The brochure is available online or in<br />

hard copy and features Clic’s entire range from<br />

its traditional, smaller-lensed Clic reader styles,<br />

to its big ‘Manhattan’ with 50ml wide lenses, a<br />

large band and flex over the ear.<br />

• Little4eyes – introduced two new children’s<br />

brands to the market, Star Wars (inspired by<br />

the 40th anniversary of the film franchise) and<br />

Tartine et Chocolat. Like the company’s other<br />

brands, Catamini and Jacadi, Tartine et Chocolat<br />

is a high-end children’s clothing brand, which<br />

has introduced a cute eyewear range for kids.<br />

Tartine et Chocolat eyewear is available through<br />

Little4Eyes in New Zealand and Australia, though<br />

Star Wars is currently only available in Australia.<br />

ODMA chair, OptiMed’s Robert Sparkes, said<br />

he was delighted with this year’s show. “This<br />

pop-up boutique event is what the independent<br />

optical industry asked for and is now a<br />

confirmed favourite. This is the kind of show that<br />

could easily move to Sydney, Brisbane or other<br />

locations if there is a demand.”<br />

Next year, the O-Show has a break while its<br />

newly revamped big sister takes over, in the<br />

form of O=MEGA19 (see side story). Where the<br />

O-Show appears in 2020, however, is still under<br />

wraps. <br />

*For more on Demodex, see p42<br />

ODMA chairman Robert Sparkes, Optometry Victoria president Murray Smith, ODMA CEO Finola Carey and Optometry<br />

Victoria CEO Pete Haydon at the launch of O=MEGA19 at the O-Show <strong>2018</strong><br />

O=MEGA19, more mega?<br />

OPTOMETRY VICTORIA (OV) and Optometry<br />

South Australia (OSA) members will vote<br />

on their proposed merger to become one<br />

representative optometry body at their AGMs<br />

in October. Should the majority of members<br />

accept the proposal, the newly amalgamated<br />

organisation will become the co-partner of<br />

the Optical Distributors & Manufacturers<br />

Association of Australia (ODMA’s) recently<br />

announced new joint event, O=MEGA19,<br />

which is replacing OV’s Southern Regional<br />

Congress (SRC) and the biennial ODMA fair.<br />

Given the timing of the members’ vote,<br />

OSA’s annual BlueSky conference will be held<br />

in November as usual, but will then move to<br />

being biennial should the members accept<br />

the merger plans. Thus O=MEGA will be held<br />

every two years (2019, 2021 etc.) in Melbourne<br />

and Blue Sky every two years in Adelaide from<br />

2020.<br />

In the ‘off’ year in the two states, a<br />

comprehensive plan of one day CPD events is<br />

also being developed, said Pete Haydon, CEO<br />

of Optometry Victoria. This CPD potential will<br />

also extend to O=MEGA19 for New Zealandbased<br />

optometrists, he added.<br />

“We’ve welcomed hundreds of New<br />

Zealand optoms to SRC over the years, and<br />

offered accredited CPD for them… I anticipate<br />

we’ll continue this arrangement and am<br />

looking forward to making O=MEGA19 a truly<br />

regional event.”<br />

O=MEGA and the proposed merger of OV<br />

and OSA also have the backing of Australia’s<br />

national optometry body, Optometry<br />

Australia. “Optometry Victoria and Optometry<br />

South Australia are putting members first<br />

and working to provide enhanced services,<br />

while ensuring great value for members,” OA<br />

national president Andrew Hogan told the<br />

association’s online magazine of the same<br />

name. While OA’s national CEO Lyn Brodie told<br />

NZ Optics, “Optometry Australia is delighted<br />

that Optometry Victoria and ODMA have<br />

joined forces to launch the new education, eye<br />

care and eye wear event, O=MEGA. It is terrific<br />

to see sector leaders challenging existing<br />

ways of doing business and finding new and<br />

interesting ways to support optometrists in<br />

meeting their clinical, patient and practice<br />

management obligations.”<br />

O=MEGA19 will be held at the newlyexpanded<br />

Melbourne Convention and<br />

Exhibition Centre from July 19-21 2019 and<br />

will include dedicated exhibition-only time to<br />

suit both delegates and exhibitors.<br />

WWW.EYEONOPTICS.CO.NZ | 51


FASHION<br />

STYLE EYES<br />

Allergic to glasses?<br />

Why specs can make your patients suffer<br />

By Renee Lunder<br />

UGLY, RED BLOTCHES; itchy, inflamed spots;<br />

oozing sores. No, this is not a description of a<br />

zombie from the latest horror flick, but a patient<br />

suffering from an allergy to their glasses.<br />

Common allergies…<br />

According to the Australasian Society<br />

of Clinical Immunology and Allergy,<br />

approximately 8% of the population has a nickel<br />

allergy. Considering nickel is present in so<br />

many things – coins, jewellery, mobile phones,<br />

keys, pens, clothing (zips/buttons/bra hooks/<br />

hairpins) and spectacle frames – it can be tricky<br />

for sufferers to avoid it.<br />

The most common reaction to nickel is<br />

dermatitis which usually presents as itchy<br />

eczema or red blisters wherever the metal<br />

touches the skin.<br />

Another allergy that gets people all itchy<br />

and scratchy is silicone. While it is rarer than a<br />

nickel allergy, it still one of the more common<br />

complaints from allergy-suffering spec wearers,<br />

with silicon nose pads causing bumps or skin<br />

rashes across the nose.<br />

… and not-so-common allergies<br />

An allergy to chemical coatings on lenses, such<br />

as scratch-resistant and anti-reflective layers,<br />

can be another cause of distress for some specswearers.<br />

The usual sign is eye irritation.<br />

Plastic is yet another offender, but this one<br />

can be infinitely harder to diagnose as frames<br />

are usually made out of a combination of<br />

materials. The allergy could very well be linked<br />

to the solvents, rubbers, dyes or waxes used to<br />

make the frames. Reactions are similar to those<br />

who have a nickel allergy.<br />

Allergy versus irritant<br />

It’s hard to distinguish between an allergic<br />

reaction to something the glasses are made<br />

from and an irritation caused by the glasses<br />

themselves as symptoms are similar. With<br />

Nickel allergy<br />

irritations, repeated contact or<br />

friction with frames can cause<br />

a rash to appear; heat (sweat)<br />

can also be a factor here.<br />

Allergies, however, occur<br />

when a person is oversensitised<br />

to a substance in the<br />

specs and the patient’s immune<br />

system reacts by producing<br />

rashes and blisters. The best way to<br />

distinguish between the two is through<br />

allergy testing.<br />

Helping allergic specs-wearers<br />

There are a number of options for allergy<br />

patients. First, suggest they track their<br />

symptoms over a certain period of time to work<br />

out if it is their specs that are the problem. Ask<br />

them to carefully note down exactly<br />

where the rash appears and what it<br />

looks like – is it mask-like or behind<br />

their ears? If their glasses appear<br />

to be the perpetrator, suggest they<br />

are allergy tested for nickel, plastics,<br />

silicone and other common chemicals<br />

found in coatings. As a tip: if a customer<br />

has an allergy to costume jewellery, they<br />

are likely to have a nickel allergy.<br />

For nickel and plastic allergy sufferers,<br />

recommend titanium, stainless steel or noble<br />

metal (pure gold or silver) frames as these are<br />

far less likely to cause a reaction.<br />

But be cautious when suggesting titanium<br />

alloy frames as there’s a chance there’s some<br />

nickel mixed in. If you aren’t sure about the<br />

composition of a frame, you can invest in an<br />

inexpensive nickel-allergy testing kit. Test all<br />

components of the glasses from frame to screws<br />

to hinges, the solution won’t harm the frame so<br />

it will still be sellable!<br />

If a customer has a silicone allergy, there<br />

are plenty of alternative nose pad options on<br />

the market. Consider vinyl,<br />

titanium or stainless-steel<br />

pads instead.<br />

You may need to do some<br />

extra legwork contacting<br />

manufacturers and suppliers<br />

to find out what allergy-free<br />

alternatives are out there or<br />

to determine all the elements<br />

in a particular frame. So,<br />

it’s good to keep records about your patient’s<br />

reactions to frames and note down what works<br />

for them.<br />

If you wanted to go the extra mile and set<br />

yourself a little more apart from your peers,<br />

you might want to consider researching and<br />

stocking a number of hypoallergenic frames,<br />

which take all spec parts into consideration –<br />

the screws, hinges, pads and temples – ensuring<br />

none contain potential allergens.<br />

It’s a bit of added work, but your allergy<br />

patients will love you for it, and so will their<br />

families! <br />

Renee Lunder is an Australian<br />

freelance journalist and proud<br />

specs wearer.<br />

Allergy-friendly titanium and<br />

gold specs from Blackfin, and<br />

titanium nose pads<br />

52 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


Fashion update<br />

Kate Sylvester<br />

Kate Sylvester’s spring collection<br />

features three new sun- and five<br />

optical frames. The collection offers<br />

“strong, feminine shapes imbued<br />

with Kate’s understated, effortless<br />

aesthetic and introduces pops<br />

of rose pink and vibrant green<br />

alongside a tonal colour palette,”<br />

said the company. An avid reader,<br />

Sylvester has named her optical<br />

frames after authors she loves.<br />

Featured here is Renata (Renata<br />

Alder) while the sunglasses are<br />

named after some of her favourite<br />

book characters, for example Peggy<br />

(Guggenheim) and Dorian (Gray).<br />

Distributed by Phoenix Eyewear.<br />

Stars<br />

eyes<br />

and<br />

their<br />

Shannon<br />

Bream<br />

Dokomotto<br />

After a successful introduction of<br />

Dokomotto in New Zealand, Beni<br />

Vision is extending the French<br />

brand’s handmade frames portfolio,<br />

offering pairs from its classic frame<br />

collection “Seaman”.<br />

As with the designer range, the<br />

acetate collection is limited to 500<br />

pieces worldwide. Distributed by<br />

Beni Vision.<br />

WOOW and Face à Face<br />

Woow’s new season range has<br />

re-interpreted the big ʹ70s<br />

shapes and styles and introduced<br />

transparencies in new and<br />

different ways. Illustrated here<br />

by its bold Pop-Up frame featuring<br />

a combination of<br />

thin metal and<br />

colourful acetate.<br />

Face à Face’s<br />

new concepts have<br />

also arrived and<br />

like its sister brand Woow,<br />

they play with transparencies<br />

and colours. Blast, featured here,<br />

gives the wearer an “edgy look”<br />

and is available in two shapes, ʹ50s<br />

inspired high-square and wide<br />

Lacoste<br />

Lacoste Eyewear has extended its<br />

tweens design concept to include<br />

two new junior frames. Designed<br />

for sporty kids, the company says<br />

the frames are durable with vibrant<br />

colours and playful finishes. The oval<br />

Lacoste 3628 featured here has soft<br />

rubber nose pads for comfort and the<br />

distinctive Lacoste rubber croc on<br />

both temples. Available in a variety<br />

of happy colour combinations.<br />

Distributed by VSP Australia.<br />

classic cat-eye, and comes in five<br />

different colours. Distributed by<br />

Eyes Right Optical.<br />

Well-known US Fox News reporter Shannon Bream, a former lawyer and<br />

crowned beauty queen, battled through 18 months of excruciating pain<br />

and chronic fatigue as a result of undiagnosed recurring corneal erosions<br />

(epithelial basement membrane dystrophy).<br />

In a Washington Post interview, Bream described how it started in 2010,<br />

waking her up with a pain in her left eye “so searing it sat me straight up<br />

in bed”. Her eye was tearing profusely but after a few hours, the pain and<br />

tearing subsided. After a few recurring episodes, Bream sought help from<br />

her optometrist who suggested she could be suffering from dry eye and<br />

prescribed lubricating eye drops. When the problem kept recurring, the<br />

optometrist referred Bream to an ophthalmologist.<br />

Bream said she turned to a respected corneal specialist in Virginia who<br />

agreed that dryness was the most likely cause and prescribed Restasis, a<br />

treatment for chronic dry eye. Initially, this helped ease the pain, said<br />

Bream, but then the pain and tearing became more frequent, with both<br />

eyes suffering episodes several times a week.<br />

Her ophthalmologist urged her to be patient, but after several months,<br />

Bream said she was getting desperate; waking every two or three hours a<br />

night to put in her eye drops, and existing in a perpetual state of chronic<br />

fatigue and pain. She returned again to her ophthalmologist, but again<br />

he told her to be patient and said she was probably overreacting and<br />

“emotional”. This was a devastating blow, Bream told the Washington<br />

Post, adding by then she had started to doubt she would ever find<br />

relief. But her husband urged her to seek advice from a different<br />

ophthalmologist and Bream reluctantly set up an appointment with a<br />

Washington corneal specialist.<br />

Anxious at the prospect of not being taken seriously, Bream described<br />

her immense relief when during the examination, the specialist<br />

explained he could see her cornea was covered with tiny, superficial<br />

scratches and signs of a disorder called map-dot-fingerprint dystrophy,<br />

featuring clusters of dots resembling fingerprints on layers of the cornea.<br />

The Washington cornea specialist explained the condition, most<br />

common in people aged 40-70, results in cellular abnormalities causing<br />

the corneal epithelium to weakly adhere to the underlying membrane,<br />

exposing the underlying nerves, which can be excruciatingly painful.<br />

Several weeks later, as Bream’s eyes had finally begun to heal using the<br />

ointment and eye drops prescribed, she said she slept a whole night for<br />

the first time in a year.<br />

“It felt like I’d won the $300 million lottery,” she said.<br />

WWW.EYEONOPTICS.CO.NZ | 53


NEWS<br />

Silmo<br />

Sydney <strong>2018</strong><br />

By Lesley Springall<br />

THE SECOND SILMO Sydney was a quieter<br />

affair than its inaugural unveiling last year,<br />

with few of the major equipment and frames<br />

companies that were exhibiting the weekend<br />

prior, in Melbourne at its rival ODMA’s O-Show<br />

(see p50).<br />

That said, this year’s show still featured some<br />

eye-catching stands. One was the stunning,<br />

more avant garde frame offerings from Patrick<br />

Quinn, owner-operator of Perth-based<br />

optometrists Blink 138.<br />

Patrick and his son James, both dispensing<br />

opticians, have been making their own specs<br />

for about eight years before deciding to set up<br />

Quinn Eyewear and introduce them to others.<br />

The pair unveiled their collection at Vision<br />

Expo East in New York in March and, despite<br />

being in the boondocks of the show on a shared<br />

stand, quickly snapped up three American<br />

accounts. Silmo Sydney was their second show<br />

and father and son said they were both excited<br />

and terrified, but also pleasantly surprised at the<br />

interest they’d received.<br />

According to the show’s organisers, Expertise<br />

Events, despite the quieter turnout, other<br />

exhibitors were also pleased with event sales.<br />

“Came with zero expectations, happily surprised,”<br />

Sam Tomashover from Mattisse Handpainted<br />

Eyewear told Expertise. “An incredible success.<br />

Saw qualified and quality buyers,” added Mark<br />

Blackadder from MYM Group.<br />

The show was supported by its far larger<br />

European namesake through the presence of<br />

Silmo Paris director Eric Lenoir who flew into<br />

Sydney for just a few days to be there.<br />

“Silmo Sydney is proud to be a ‘buyer-led’<br />

show,” said Gary Fitz-Roy, managing director<br />

of Expertise Events. “The market has evolved<br />

– it’s no longer about the volume of visitors, it’s<br />

about delivering the right audience. Having a<br />

show that has a strong frame focus is important<br />

as they are constantly changing and evolving<br />

with market trends and are a major contributor<br />

to optometry practices’ and retail outlets’<br />

profitability.” <br />

An eye for music<br />

Mercury Bay optometrist Brett Howes has<br />

written and released his latest composition<br />

Lovelight, sung by New Zealand singer-song<br />

writer and Kiwi Indie music champion LA<br />

Thompson (aka Shirley Howe).<br />

When not an optometrist, specialising in sports<br />

vision and soft contact lenses, Howes has been<br />

creating music for 20 years and recording pieces<br />

for about 11 years.<br />

Described as a soulful ballad, Lovelight came to<br />

him at a close friend’s funeral. He wrote a few<br />

lyrics and chord sequences during the service<br />

and completed it later in collaboration with<br />

pianist Kevin Crowe, to honour his dear friend,<br />

he said. To hear the song for yourself, head to<br />

https://youtu.be/tXyOjByi8N<br />

Eschenbach Optik’s Brett Sheil and MSO’s Rae Long and<br />

Gethin Sladen<br />

Patrick and James Quinn and their new eye-catching frames range<br />

Silmo Sydney will return to Sydney’s International<br />

Convention Centre from 5-7 July 2019, two weeks<br />

ahead of its larger Australasian rival, ODMA’s<br />

new O=MEGA19 in Melbourne from 19-21 July<br />

2019 (see p51).<br />

Fleye Eyewear’s Annette Estø and<br />

Silmo Paris director Eric Lenoir<br />

will.i.am specs<br />

Specsavers has launched an exclusive, new<br />

eyewear range from musician, producer<br />

and entrepreneur will.i.am. Building on his<br />

lifelong passion for striking eyewear, the<br />

17-piece collection is inspired by the hip<br />

hop icons of his youth, such as Run DMC<br />

and Flava Flav, and references classic and<br />

iconic styles with a twist, said will.i.am.<br />

“What makes my collection and designs<br />

unique are the subtleties and attention to<br />

detail that gives them extra ‘oomph’, while<br />

remaining entirely wearable.” Any outfit is<br />

incomplete without a great pair of glasses,<br />

he added.<br />

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54 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


CLASSIFIEDS<br />

Transitions: light<br />

under control<br />

HOT ON THE heels of unveiling its new branding, Transitions Optical<br />

has launched a new consumer campaign Light Under Control.<br />

The new campaign and rejuvenated brand aims to recruit new<br />

wearers and attract a younger generation of single vision wearers to<br />

the photochromic lens category, and responds to research showing<br />

that 87% of glasses wearers report being sensitive to light, said Stuart<br />

Cannon, Transitions Optical general manager for Asia Pacific.<br />

“The Light Under Control campaign dramatises light, making light the<br />

hero of our story. Light is<br />

illuminating but it can also<br />

be harmful or inhibiting. So,<br />

it has to be under control.<br />

Our light-intelligent lenses<br />

allow a hassle-free life, with<br />

ultimate light protection.”<br />

Starting in October,<br />

Transitions is running an<br />

online consumer media<br />

campaign, aimed at<br />

younger wearers, using<br />

selected social media<br />

influencers.<br />

To order your new campaign<br />

free point-of-sale material,<br />

see Transitions’ ad on p9.<br />

To advertise in<br />

NZ Optics classified section<br />

contact Susanne Bradley<br />

susanne@nzoptics.co.nz<br />

Print and online<br />

SO MUCH MORE<br />

THAN JUST A FAIR<br />

FROM SEPTEMBER 28 TH<br />

TO OCTOBER 1 ST <strong>2018</strong><br />

PARIS NORD VILLEPINTE<br />

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• Choose to work with luxury brands<br />

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• Choose from varying locations across<br />

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• Choose higher hourly rates than agency<br />

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Meet extraordinary people, make new<br />

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CONTACT DAVID<br />

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OPSM.COM.AU<br />

WWW.EYEONOPTICS.CO.NZ | 55<br />

LX95_OPSM_Classified_NZOpticsLocum_102.5x142mm.indd 1<br />

15/8/18 4:51 pm


CLASSIFIEDS<br />

To advertise in<br />

NZ Optics classified<br />

section contact<br />

Susanne Bradley<br />

susanne@nzoptics.co.nz<br />

Print and online<br />

For all your<br />

optical and<br />

ophthalmic<br />

needs<br />

nzowa.org.nz<br />

FULL-TIME OPTOMETRIST<br />

Christchurch<br />

Our practices support independent optometric practice and value an<br />

optometrist who has a passion for clinical excellence and patient care.<br />

The Matthews group prides itself on being a family owned and operated<br />

business and professional growth in all optometry sub- specialties is<br />

encouraged.<br />

We are the largest independent optometry group in NZ, with plans for<br />

future growth. We are looking for someone to join us in our Christchurch<br />

practices, who is passionate about optometry and wants to be part of a<br />

company striving for excellence.<br />

Please contact John Grylls, john.grylls@seekapiti.co.nz or Michelle Diez,<br />

michelle.diez@matthews.co.nz for more information.<br />

Confidentiality is assured.<br />

BAILEY NELSON - OPTOMETRIST<br />

Riccarton, Christchurch<br />

Here at Bailey Nelson, we see things a little differently.<br />

We believe eye care doesn’t have to be boring, and that’s why it’s our<br />

mission to have passionate and caring Optometrists who ensure all<br />

patients enjoy an experience worth remembering.<br />

Our eye tests are tailored for each individual so everyone walks away<br />

feeling and looking different.<br />

Bailey Nelson currently has a vacancy in Riccarton. If you want to further<br />

yourself as a leader and business contributor, all while delivering amazing<br />

eye care then get in touch.<br />

To apply, please contact Maddy Mortiaux on 021 351 401<br />

or maddy@baileynelson.co.nz<br />

OPTOMETRISTS WANTED<br />

South Australia & Victoria<br />

Kevin Paisley Optometry is looking for confident and passionate<br />

optometrists to join our Mt Gambier, Naracoorte and Portland stores in<br />

<strong>Sep</strong>tember <strong>2018</strong>. If you have a focus on exceptional patient care, client<br />

service and enjoy working within an experienced team, this is for you!<br />

Attractive salary package, relocation allowance, fully-maintained car<br />

and bonus scheme is on offer as well as mentoring and professional<br />

development. This is an ideal opportunity to grow your optometry career.<br />

New graduates are encouraged to apply.<br />

Our Mt Gambier and Naracoorte stores are located in beautiful South<br />

Australia, and the Portland store is on the stunning Victoria coastline.<br />

If this sounds interesting to you, please forward CV to Darren Wills,<br />

darrenw@theopticalco.com.au or +61 424 989 600<br />

Thinking of selling your practice?<br />

Optics NZ specialises in optometry practice<br />

sales, we’ve helped dozens of Optometrists buy<br />

and sell their practices.<br />

WORKING AT OPSM<br />

MEANS YOU’RE PART<br />

OF SOMETHING BIGGER<br />

At OPSM, we are passionate about opening<br />

eyes to the unseen. Our advanced technology<br />

enables us to look deeper to ensure we give<br />

the best care to every customer.<br />

We currently have opportunities for passionate,<br />

energetic optometrists in a variety of metro and<br />

regional Queensland and Northern Territory<br />

locations: Brisbane, Gold Coast, Darwin, Cairns,<br />

Hervey Bay, Lismore, Townsville and Ballina.<br />

Whether you like the city, the surf or the outback,<br />

you will be welcomed into a dynamic and<br />

supportive team and work with our world-class<br />

technology including the Optos Daytona ultra-wide<br />

field scanner. Very attractive remuneration packages<br />

can be tailored to the right person and we can<br />

also offer you many opportunities for continuing<br />

professional development through financially<br />

supported industry training, conferences, peerlearning<br />

communities and product training.<br />

If you are a passionate professional, who is eager<br />

to build loyal and trusting relationships, this is the<br />

opportunity for you! You can look to take on a fixed<br />

period role or even consider a more permanent move.<br />

CONTACT: BRENDAN PHILP<br />

brendan.philp@luxottica.com.au or call 0418 845 197<br />

LEARN MORE OPSM.COM.AU/CAREERS<br />

Contact Stuart Allan on 03 546 6996 or 027 436 9091<br />

stu@opticsnz.co.nz www.opticsnz.co.nz<br />

Locum Service • Recruitment Services<br />

Practice Brokering • Business Consultants<br />

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OPTOMETRIST<br />

Invercargill<br />

SEEKING AMAZING OPTOMETRISTS<br />

Cambridge / Tokoroa / TeAwamutu / Waiuku<br />

We’re on the hunt for passionate optometrists! Whether you are looking to<br />

relocate to the Waikato or Waiuku for that lifestyle change or just wanting<br />

to base yourself outside the Auckland madness, we can make it worth your<br />

while!<br />

What do you need to apply for these amazing roles?<br />

Experience<br />

1-2 years’ experience will be beneficial but not essential<br />

Skills and abilities<br />

Excellent talent to interact with people in a positive and courteous manner<br />

Strong written and verbal communication skills<br />

Dependable and punctual<br />

Sparkling and caring personality that can provide our patients the best<br />

experience possible<br />

The benefits<br />

Competitive salary - we’ll make it worth your while!<br />

Opportunities to specialise in your personal field of interest<br />

Being part of an amazing independent company in a fun and supportive<br />

environment<br />

Flexible working arrangements<br />

We are looking for a friendly and enthusiastic Optometrist to join our busy<br />

and growing optometry practice in Invercargill. This position would suit<br />

someone who is seeking:<br />

Excellent work-life balance<br />

With a short, five to 10-minute drive to work, and a nine to five, Monday<br />

to Thursday working week, you can enjoy more free time with family and<br />

friends.<br />

An opportunity to get ahead<br />

With an extremely competitive remuneration package and an average<br />

house price in Invercargill of only $260,000, this position represents a great<br />

opportunity.<br />

A great place to live<br />

Invercargill is only a few hour’s drive/ferry from some of New Zealand’s<br />

most beautiful destinations, including Queenstown, Milford Sound,<br />

Stewart Island and the Catlins.<br />

Professional development<br />

Our friendly and supportive team, with over 40 years of optometry<br />

experience, and over 35 years of combined dispensing experience, can<br />

help take your career to the next level.<br />

If this sound like the ideal role for you, please email your CV and cover<br />

letter to 7720store@opsm.co.nz<br />

Recommend your friend (or yourself) to send their brilliant cover letter<br />

and CV (indicating which practice you would like to work in) to Sandri<br />

Killian on sandri.killian@patersonburn.co.nz<br />

READY FOR A CHANGE?<br />

When you join OPSM, you work within<br />

a team who are committed to providing<br />

the best possible eyecare solution with<br />

exceptional customer service. You will<br />

work with world class technology<br />

and have many opportunities for<br />

professional development. You can<br />

also make a real difference in the<br />

way people see the world by<br />

participating in our OneSight outreach<br />

program. OPSM New Zealand is looking<br />

for passionate Optometrists to join the<br />

team in these locations:<br />

– TAUPO<br />

– AUCKLAND<br />

– THAMES<br />

JOIN OUR TEAM<br />

If you are interested to find out more about<br />

joining the team, contact Jonathan Payne<br />

for a confidential chat.<br />

jonathan.payne@opsm.co.nz or<br />

call 021 195 3549<br />

OPSM.CO.NZ/CAREERS<br />

EXPERIENCED OPTOMETRISTS<br />

FULL-TIME AND PART-TIME<br />

Nelson Tasman / Top of the South<br />

Ever had the desire to move to Nelson, but finding the right role was always<br />

the challenge? Well, here is your chance.<br />

The Positions<br />

Nelson and Richmond Specsavers are looking to appoint a full-time<br />

experienced Optometrist and a part-time Optometrist. Both positions<br />

are available as soon as the right candidates are recruited, but ideally, the<br />

client would need the vacancies filled by 1 December <strong>2018</strong>. Top salary<br />

levels can be expected for the right candidates.<br />

Both practices (Nelson and Richmond) have a positive team culture, superb<br />

equipment (OCT in both practices) and highly-experienced support staff.<br />

The Richmond practice has just been refitted, with a spacious 240m2 and<br />

four consulting rooms. Both practices operate on 25 to 30-minutes testing.<br />

There is also the long-term opportunity to consider becoming a partner in<br />

the businesses and the risk/reward potential here is one of the most secure<br />

we have been involved with for a long time.<br />

The Location<br />

The Nelson region is blessed with a some of the country’s highest sunshine<br />

hours, with mild winters and warm summers and easy access to multiple<br />

national parks. The locale is also known for its wines, fruit, hops, and<br />

vibrant art and cafe culture. Nelson provides a slower pace of life and a<br />

lower cost of living. Everything is within easy access; there are seldom any<br />

traffic issues. The region also benefits from having nationally recognised<br />

education options, excellent healthcare professionals and the countries<br />

fourth busiest airport ensures you will remain well connected to the<br />

balance of the country.<br />

Next Steps<br />

To apply you must be eligible to work in New Zealand and have a current<br />

annual practising certificate. If you do not meet these criteria, please do<br />

not apply.<br />

Applications close at 5pm Thursday 25 October <strong>2018</strong>.<br />

Please send your CV and cover letter outlining your skills and experience<br />

to: Stuart Allan at OpticsNZ, PO Box 1300, Nelson T: (03) 5466 996,<br />

M: (027) 436 9091, E: stu@opticsnz.co.nz<br />

WWW.EYEONOPTICS.CO.NZ | 57


Chalkeyes presents...<br />

Slack Times<br />

By David Slack<br />

Not drowning, waving at sharks<br />

PEOPLE COME FROM all over to see the<br />

biggest tourist attraction in Auckland. Paris has<br />

a tower, San Francisco has a bridge, Auckland<br />

has an old sewage tank. Down under the ground<br />

you go, and for 30, 40 dollars you get to take a<br />

good old look around. Of course, it’s a bit more<br />

than a sewage tank. It has penguins. It has a gift<br />

shop. It has a perspex tunnel that makes it feel<br />

like you’re under the sea. And, it has sharks.<br />

People love Kelly Tarlton’s. I couldn’t count<br />

how many times we took our daughter and<br />

she stood patiently in line for an hour or more.<br />

Much more patiently than me. Years later, she<br />

told me the look I sometimes get is, “your Kelly<br />

Tarlton’s queue face.”<br />

But what a great object lesson. With a bit of<br />

imagination you can go so very far. I want to<br />

go from one side of the harbour to the other.<br />

My great dream of nearly 20 years now is an<br />

underwater tunnel between the picturesque<br />

seaside village of Devonport and the city. An<br />

under-harbour tunnel connecting us to the<br />

bottom of Queen Street, with one of those<br />

travellator things you get in big international<br />

airports. And all under a perspex cover, like<br />

Kelly Tarlton’s.<br />

acceleration from breaking people. The same<br />

in reverse at the other end... could you create<br />

an artificial tail wind to help negate the air<br />

resistance?”<br />

It turned out that very question was already<br />

being tackled elsewhere. In France - where<br />

they call it a trottoir - I found they had one at<br />

a station interchange inside the Paris metro.<br />

It was 180 metres long and accelerating up to<br />

11 km/hr. Hell, that’s nothing, I thought. We’re<br />

bungee jumpers here. I’d say we’re good for<br />

hanging on at 30km/hr, no worries!<br />

Another said: “Maybe you should get Kelly<br />

Tarlton’s in on the action and make the tunnel<br />

perspex. You’d probably want to clean up the<br />

You wrap the tunnel in another layer of perspex,<br />

and you fill that up with warm water and fill it up<br />

with beautiful tropical fish. A beautiful Samoan<br />

reef here in our chilly waters.<br />

that murky water?” And then I thought: no<br />

worries. You wrap the tunnel in another layer of<br />

perspex, and you fill that up with warm water<br />

and fill it up with beautiful tropical fish. A<br />

beautiful Samoan reef here in our chilly waters.<br />

Imagine it. You just stroll whenever you<br />

like from one side to the other. You get to the<br />

bottom of Queen St, you just keep on rolling,<br />

to Devonport. No need for a multi-billiondollar<br />

harbour crossing, just a beautiful tourist<br />

attraction to stroll across or glide through on<br />

your e-bike. My liberal-minded friends also like<br />

the idea that if the coming referendum takes us<br />

in the direction of legalised weed, well, people<br />

will be down there in the perspex with the<br />

tropical fish all day long, my dudes.<br />

You may say I’m a dreamer, but I’m not the<br />

only one who’s watched The Castle. The story of<br />

life is the way we can climb down into a sewage<br />

tank, take a look around and say: “Okay, here’s<br />

what we can do. Who’s got a tape measure? Who<br />

knows about sharks? And do we know anybody<br />

who makes perspex?”<br />

Just imagine! <br />

I have been banging on about this idea<br />

forever. I enthused about it to the mayor of<br />

Auckland. His eyes glazed over. I proposed it in<br />

a debate with our Prime Minister. She didn’t say<br />

no, reader, she didn’t say no. I live in hope.<br />

And, I offer this as a little object lesson<br />

in how a rough little nub of an idea can turn<br />

into something more through the magic of<br />

collaboration. As soon as I first wrote about it<br />

(at this point all I imagined was an underwater<br />

travellator in a tunnel) people were helpfully<br />

suggesting how to make it better.<br />

“I can’t help but wonder how fast you<br />

could make a travellator that long,” one<br />

said. “Obviously you’d need several abutting<br />

travellators of graduating speeds to keep the<br />

scum that is our harbour and you’d need some<br />

clever robot thingy to keep it clean, but wouldn’t<br />

it be cool to have the harbour as a sightseeing<br />

attraction?”<br />

This was the genius moment for me. Ever<br />

since, I have believed in the power of perspex.<br />

That particular responder also said: “Of course<br />

you’d want to make the harbour a marine<br />

reserve to get the fish back but seriously how<br />

many people do you know who are silly enough<br />

to eat fish caught in the inner harbour?”<br />

Years went on. I wrote about it; I talked on<br />

the radio about it; I bored New Zealand about<br />

it. “We love it,” said a few people. “Have another<br />

drink” said others. Various people said to me:<br />

“Well okay, but how will you see anything in<br />

David Slack is an author,<br />

radio and TV commentator and<br />

speechwriter. He established<br />

the website speeches.com, and<br />

has published several books<br />

including ‘Bullshit, Backlash<br />

and Bleeding Hearts’, exploring<br />

Treaty of Waitangi issues, and<br />

‘Bullrush’, a social history of the<br />

popular children’s game.<br />

58 | NEW ZEALAND OPTICS SEPTEMBER <strong>2018</strong>


<strong>2018</strong> • Voted by Australians • <strong>2018</strong><br />

<strong>2018</strong> • Voted by New Zealanders • <strong>2018</strong><br />

Voted by New Zealanders<br />

HERE TO HELP<br />

LOOKING FOR WORK? LOOK NO FURTHER.<br />

Are you an optometrist looking to advance to the next stage of your career? We’ve got good news for you.<br />

Specsavers Recruitment Services (SRS) is a team of professional recruitment specialists dedicated to placing<br />

talented and passionate optometrists from all stages of their careers into desired employment.<br />

With strong relationships with all Specsavers optometry business partners and a<br />

comprehensive understanding of the two markets we operate in, we’re the perfect<br />

solution to help you take the next step in your optometry journey.<br />

Our locally based consultants are readily available to answer any questions you have.<br />

We can assist with:<br />

• A dedicated consultant who will tailor their service to support your needs<br />

• Employment opportunities in our 52-strong store network across varying<br />

levels – locum, permanent, fixed-term contract, full-time and part-time<br />

• Guidance and support in helping you become a self-employed locum<br />

• Management of locum diaries (work as little or as much as you like)<br />

and travel bookings<br />

• Advice on market-rate salaries and assistance in negotiating the right<br />

salary for you<br />

• Guidance on the right store for you in your preferred area/s<br />

• The most up-to-date live locum and permanent vacancies across New Zealand<br />

(sent out twice a week)<br />

• Special offers and bonuses including referring a friend (up to $16K) and VIP<br />

packages to industry events<br />

• Exclusive FIFO / DIDO employment opportunities managed entirely by<br />

SRS – you could earn up to $150,000!<br />

Looking for a sea change? We can also help you relocate between Australia<br />

and New Zealand.<br />

We are a free service backed by experts who are experienced at getting our network<br />

of partners and optometrists the best possible outcomes.<br />

So – what are you waiting for? Get in touch today and find out more.<br />

For a confidential chat about the various opportunities we have available,<br />

contact Chris Rickard on 027 579 5499 or email chris.rickard@specsavers.com<br />

VIEW ALL THE OPPORTUNITIES AVAILABLE ON SPECTRUM-ANZ.COM<br />

Reader’s<br />

Digest<br />

Quality Service<br />

Award<br />

Reader’s<br />

Digest<br />

Quality Service<br />

Award<br />

AITD<br />

Reader’s Digest<br />

Quality Service<br />

Award<br />

2017<br />

Best<br />

Wellbeing<br />

Project<br />

<strong>2018</strong><br />

Best Customer<br />

Service in AU<br />

Optometry<br />

<strong>2018</strong><br />

Best Customer<br />

Service in NZ<br />

Optometry<br />

<strong>2018</strong><br />

Best Talent<br />

Development<br />

Program<br />

2017<br />

Best Talent<br />

Development<br />

Program<br />

2017<br />

Best Customer<br />

Service in NZ<br />

Optometry<br />

2017<br />

Millward Brown<br />

Research<br />

No.1 for eye tests<br />

2016<br />

Excellence in<br />

Marketing<br />

Award<br />

2016<br />

Retail<br />

Store Design<br />

Award<br />

2016<br />

Transforming eye health


LAUNCHING<br />

LATE <strong>2018</strong>

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