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HEALTH<br />

THURSdAY,<br />

JANUARY <strong>17</strong>, 2<strong>01</strong>9<br />

5<br />

Why exercise alone won’t save us<br />

Vybarr Cregan-Reid<br />

This is the time of year when<br />

trainers are mined from<br />

under beds and gym kits are<br />

disinterred from the bottom<br />

drawer. Google searches<br />

relating to physical fitness<br />

peak in January. Many<br />

people even trawl the web to<br />

find out about "desk<br />

exercises" and "workouts on<br />

the go" in case they are too<br />

busy to use their new gym<br />

memberships.<br />

Our relationship with<br />

exercise is complicated.<br />

Reports from the UK and<br />

the US show it is something<br />

we persistently struggle<br />

with. As the new year rolls<br />

around, we anticipate<br />

having the drive to behave<br />

differently and become<br />

regular exercisers, even in<br />

the knowledge that we will<br />

probably fail to do so. Why<br />

do we want to exercise?<br />

What do we expect it to do<br />

for us? We all know we are<br />

supposed to be exercising,<br />

but hundreds of millions of<br />

us can't face actually doing<br />

it. It is just possible the<br />

problem lies at the heart of<br />

the idea of exercise itself.<br />

Exercise is movement of<br />

the muscles and limbs for a<br />

specific outcome, usually to<br />

enhance physical fitness. As<br />

such, for most of us, it is an<br />

optional addition to the<br />

working day - yet another<br />

item on a long list of<br />

responsibilities alongside<br />

the fulfilment of parental<br />

duties or earning money to<br />

put food on the table. But<br />

because the principal<br />

beneficiary of exercise is<br />

ourselves, it is one of the<br />

easiest chores to shirk. At<br />

the end of the working day,<br />

millions of us prefer to<br />

indulge in sedentary leisure<br />

activities instead of what we<br />

all think is good for us: a<br />

workout.<br />

We need to step out of sedentary lifestyles.<br />

Fitness crazes are like<br />

diets: if any of them worked,<br />

there wouldn't be so many.<br />

CrossFit, the intensely<br />

physical, communal<br />

workout incorporating free<br />

weights, squats, pull-ups<br />

and so forth, is still less than<br />

20 years old. Spin classes -<br />

vigorous group workouts on<br />

stationary bikes - have only<br />

been around for about 30.<br />

Aerobics was a craze about a<br />

decade before that, although<br />

many of its high-energy<br />

routines had already been<br />

around for a while. (The<br />

pastel horror of 1970s<br />

Jazzercise is probably best<br />

forgotten.) Before that, there<br />

was the jogging revolution,<br />

which began in the US in the<br />

early 1960s. The Joggers<br />

Manual, published in 1963<br />

by the Oregon Heart<br />

Foundation, was a leaflet of<br />

about 200 words that sought<br />

to address the postwar panic<br />

about sedentary lifestyles by<br />

encouraging an accessible<br />

form of physical activity,<br />

explaining that "jogging is a<br />

bit more than a walk". The<br />

jogging boom took a few<br />

years to get traction, hitting<br />

its stride in the mid- to late-<br />

80s, but it remains one of<br />

the most popular forms of<br />

exercise, now also in groups.<br />

The exercise craze that<br />

dominated the 1950s was,<br />

oddly, not even an exercise.<br />

The vibrating exercise belt<br />

Photo: Laurène Boglio<br />

promised users could<br />

achieve effortless weight loss<br />

by having their midriffs<br />

violently jiggled. It didn't<br />

work, but you can still find<br />

similar machines available<br />

for purchase today.<br />

These fads even came with<br />

their own particular fashions<br />

- legwarmers, leotards,<br />

Lycra. So is our obsession<br />

with fitness doomed to be<br />

the stuff of embarrassing<br />

passing "phases"? Is exercise<br />

itself a fad?<br />

t is not news that we are<br />

becoming more sedentary as<br />

a species. The problem has<br />

been creeping up on us for<br />

generations. As industry and<br />

technology solved the<br />

physical demands of manual<br />

labour, they created new<br />

challenges for the human<br />

body.<br />

Evidence about bone<br />

strength and density gleaned<br />

from fossils of early humans<br />

suggests that, for hundreds<br />

of thousands of years,<br />

normal levels of movement<br />

were much higher than ours<br />

today. And the range of work<br />

required of the human body<br />

to subsist was sizeable:<br />

everything from foraging for<br />

food and finding water to<br />

hunting, constructing basic<br />

shelters, manufacturing<br />

tools and evading predators.<br />

The fossil record tells us that<br />

many prehistoric humans<br />

were stronger and fitter than<br />

today's Olympians.<br />

A hundred years ago,<br />

while life was easier than it<br />

had been for our huntergatherer<br />

forebears, it was<br />

still required that shopping<br />

was fetched, floors<br />

scrubbed, wood chopped<br />

and washing done by hand.<br />

Modern<br />

urban<br />

environments do not invite<br />

anything like the same kinds<br />

of work from the body. It is<br />

not easy to clock up those<br />

miles when cities are built to<br />

prioritise cars and treat<br />

pedestrians as secondary.<br />

We are not assisted by our<br />

environments to move like<br />

we used to, for reasons tied<br />

up with motivation, safety<br />

and accessibility.<br />

Technological innovations<br />

have led to countless minor<br />

reductions of movement. To<br />

clean a rug in the 1940s,<br />

most people took it into their<br />

yard and whacked the<br />

bejeezus out of it for 20<br />

minutes. Fast-forward a few<br />

decades and we can set<br />

robot vacuum cleaners to<br />

wander about our living<br />

rooms as we order up some<br />

shopping to be delivered,<br />

put on the dishwasher, cram<br />

a load into the washer-dryer,<br />

admire the self-cleaning<br />

oven, stack some machinecut<br />

logs in the grate, pour a<br />

glass of milk from the frostfree<br />

fridge or thumb a<br />

capsule into the coffee<br />

maker. Each of these devices<br />

and behaviours is making it<br />

a bit more difficult for us to<br />

keep moving regularly<br />

throughout our day.<br />

Cause of polycystic ovary<br />

syndrome discovered<br />

Alice Klein<br />

The most common cause of female<br />

infertility - polycystic ovary<br />

syndrome - may be caused by a<br />

hormonal imbalance before birth.<br />

The finding has led to a cure in mice,<br />

and a drug trial is set to begin in<br />

women later this year.<br />

Polycystic ovary syndrome affects<br />

up to one in five women worldwide,<br />

three-quarters of whom struggle to<br />

fall pregnant. The condition is<br />

typically characterised by high levels<br />

of testosterone, ovarian cysts,<br />

irregular menstrual cycles, and<br />

problems regulating sugar, but the<br />

causes have long been a mystery.<br />

"It's by far the most common<br />

hormonal condition affecting<br />

women of reproductive age but it<br />

hasn't received a lot of attention,"<br />

says Robert Norman at the<br />

University of Adelaide in Australia.<br />

Treatments are available for<br />

helping affected women get<br />

pregnant, but their success rates are<br />

typically less than 30 per cent across<br />

five menstrual cycles. Now, Paolo<br />

Giacobini at the French National<br />

Institute of Health and Medical<br />

Research and his colleagues have<br />

found that the syndrome may be<br />

triggered before birth by excess<br />

exposure in the womb to a hormone<br />

called anti-Müllerian hormone.<br />

The researchers discovered that<br />

pregnant women with polycystic<br />

ovary syndrome have 30 per cent<br />

higher levels of anti-Müllerian<br />

hormone than normal. Since the<br />

syndrome is known to run in<br />

families, they wondered if this<br />

hormonal imbalance in pregnancy<br />

might induce the same condition in<br />

their daughters.<br />

To test this idea, they injected<br />

excess anti-Müllerian hormone into<br />

pregnant mice. As their female<br />

offspring grew up, they displayed<br />

many of the hallmarks of polycystic<br />

ovary syndrome, including later<br />

puberty, infrequent ovulation,<br />

delays in falling pregnant, and fewer<br />

offspring.<br />

The excess hormone seemed to<br />

trigger this effect by overstimulating<br />

a set of brain cells that raise the level<br />

of testosterone. The team were able<br />

to reverse this effect in the mice<br />

using cetrorelix, an IVF drug<br />

routinely used to control women's<br />

hormones. After treatment with this<br />

drug, the mice stopped showing<br />

symptoms of polycystic ovary<br />

syndrome.<br />

The team is now planning a clinical<br />

trial of cetrorelix in women with the<br />

condition, which they hope to start<br />

before the end of the year. "It could<br />

be an attractive strategy to restore<br />

ovulation and eventually increase<br />

the pregnancy rate in these women,"<br />

says Giacobini. "It's a radical new<br />

way of thinking about polycystic<br />

ovary syndrome and opens up a<br />

whole range of opportunities for<br />

further investigation," says Norman.<br />

If the syndrome is indeed passed<br />

from mothers to daughters via<br />

hormones in the womb, that could<br />

explain why it's been so hard to<br />

pinpoint any genetic cause of the<br />

disorder, says Norman. "It's<br />

something we've been stuck on for a<br />

long time," he says. The findings<br />

may also explain why women with<br />

the syndrome seem to get pregnant<br />

more easily in their late 30s and<br />

early 40s, says Norman. Anti-<br />

Müllerian hormone levels are known<br />

to decline with age, usually<br />

signalling reduced fertility. But in<br />

women who start out with high<br />

levels, age-related declines may<br />

bring them into the normal fertility<br />

range - although this still needs to be<br />

tested, says Norman.<br />

Polycystic ovaries are the most common cause of fertility issues in<br />

women.<br />

Photo: Science Photo Library<br />

Our workplaces are making us sick, but there are clever ways to be careful about germiest corners.<br />

Photo: Chris Turner<br />

How to avoid getting sick<br />

in the office<br />

Yvaine Ye<br />

The headlines are lurid. One 2<strong>01</strong>2<br />

University of Arizona study swabbed<br />

chairs, phones, keyboards, computer<br />

mice and desktops in offices in New<br />

York, San Francisco and Tucson,<br />

Arizona. It found traces of more than<br />

500 different types of bacteria, the<br />

most abundant "common inhabitants<br />

of the human skin, nasal, oral or<br />

intestinal cavities". A study last year<br />

found that the "average desk contains<br />

400 times more germs than a toilet<br />

seat". In excess of 130 million UK<br />

working days were lost to sickness in<br />

20<strong>17</strong>, well over half of them due to<br />

complaints that could be picked up in<br />

the office, from colds and coughs to flu<br />

and gastroenteritis. Should we be<br />

donning hazmat suits at our desks?<br />

Probably not, says Sally Bloomfield at<br />

the London School of Hygiene and<br />

Tropical Medicine, as focusing on how<br />

many microbes there are in the<br />

working environment is highly<br />

misleading. "We're constantly<br />

shedding stuff into our environment,<br />

but these organisms are mostly<br />

harmless," she says. Unless we are<br />

made to hot-desk (see "Winning at<br />

work: Why hot-desking and open-plan<br />

offices are bad for you"), our desks are<br />

our safe havens: the microbes there are<br />

largely our own. Besides the daily<br />

commute if you use public transport,<br />

the danger zones at work are<br />

communal areas, says Bloomfield,<br />

especially shared surfaces<br />

Which fitness policy to adopt<br />

and which to ignore<br />

Sam Wong<br />

Do you start your day with a visit<br />

to a hyperbaric oxygen chamber?<br />

Or do you prefer to stare at the<br />

sun while doing yoga? These are<br />

among the rituals of four<br />

"wellness" obsessives who were<br />

profiled by The Times on 12<br />

January.<br />

The pursuit of good health is, of<br />

course, to be encouraged, but it's<br />

hardly surprising that some of the<br />

measures they reported - such as<br />

Himalayan salt lamps and a<br />

device called the<br />

"HumanCharger" - raised a few<br />

eyebrows on social media.<br />

Devotees of wellness clearly<br />

have a strong interest in the<br />

science of human health, and<br />

many of their habits have some<br />

basis in research. However, they<br />

could perhaps do with a little help<br />

at sifting evidence-based lifestyle<br />

advice from pseudoscientific guff.<br />

For anyone hoping to improve<br />

their own health, we've picked<br />

out a few of the good bits from<br />

their daily routines - and a few<br />

you should probably ignore.<br />

Sun staring - "I sun-stare<br />

because the UV rays aren't<br />

harmful to my retina the first<br />

hour after sunrise," Dasha<br />

Maximov told The Times.<br />

Though fewer UV rays will hit<br />

your retina when the sun is not<br />

yet up, they are still harmful.<br />

Staring at the sun is not a good<br />

idea at any time.<br />

HumanCharger - "It looks like<br />

an iPod and shines light into my<br />

ear to give me energy," says<br />

photographer Alex Beer. Light<br />

therapy may be useful for all<br />

sorts of things, including<br />

depression and neurological<br />

diseases, but it works best<br />

through the eyes.<br />

Seawater supplements - Tim<br />

Gray, a digital marketing agency<br />

CEO, said he takes Quinton<br />

Isotonic - "a supplement that<br />

comes from plankton and<br />

contains enzymes that help me<br />

stay hydrated". According to one<br />

website selling these products,<br />

they are 29 per cent sea water<br />

and 71 per cent spring water, so a<br />

10 ml shot of it is unlikely to do<br />

anything much.<br />

Brain-enhancing drugs - Gray<br />

also takes aniracetam, a drug he<br />

says "switches my brain on and<br />

gives me clearer thinking".<br />

Though studies have found a<br />

benefit in patients with<br />

dementia, there is minimal<br />

evidence that the drug is helpful<br />

to people with normal cognitive<br />

function.<br />

Staying hydrated - "I wake up<br />

and immediately rehydrate,"<br />

says Beer. Gray has a<br />

spreadsheet recording his<br />

hydration. Wellness enthusiasts<br />

seem to have a particular<br />

concern about staying hydrated,<br />

but the truth is if you just obey<br />

your thirst, you'll be fine.<br />

Ditching processed food -<br />

We're told we must eschew<br />

processed food, but there's no<br />

good reason to do so. They have<br />

helped us overcome hunger and<br />

reduce waste. Yoga and<br />

meditation - Yoga has wellestablished<br />

benefits for physical<br />

strength and psychological<br />

health. Mindfulness meditation<br />

can alleviate depression and<br />

anxiety, improve learning, and<br />

perhaps even slow ageing. There<br />

is also evidence that yoga and<br />

meditation can dampen the<br />

activity of genes associated with<br />

inflammation. To enhance their<br />

benefits further, you can even<br />

combine them with brain<br />

zapping.<br />

Avoid blue light in the evening -<br />

There is growing evidence that<br />

exposure to blue light in the<br />

evening disrupts our circadian<br />

rhythms and affects the quality of<br />

sleep. Switching off screens<br />

before bed, or using an app to<br />

filter out blue light, may be<br />

helpful. "When I'm working on<br />

the computer, I use a program<br />

that dims the screen according to<br />

the sun's timing in my location,<br />

Thinking of getting into wellness? Here's a helpful guide.<br />

Photo: Getty<br />

and I wear blue-light-blocking<br />

glasses," says Maximov.<br />

Get plenty of sleep - Gray has<br />

analysed his sleep for four years<br />

and found that seven hours and<br />

forty-one minutes' sleep is "the<br />

perfect amount for me". Getting<br />

less than seven hours' sleep<br />

raises your risk of obesity, heart<br />

disease, depression and early<br />

death.

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