Cellular Encounter

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How does drinking milk wage war on a cellular level? Because heat is applied to milk during the industrial preservation processes an inflammatory reaction is triggered in the intestines. The cells alert the body of a foreign element, or invader, to be eliminated. The Cellular Encounter Table Game makes the inside visible on the outside through reenacting this process. Two players drink milk while reproducing the inner invisible battle of the macrophages. The name of the game is to not play against each other but use the different pieces to win balance. Temperature, proteins (processed and not processed), sentry cells, cytokines (the chemical signals cells use to communicate) are moved on the ‘board-table’ in relation to their properties, reacting to each other in the intestinal battle field.

CELLULAR ENCOUNTER

An immunity story


How does drinking milk wage war on a cellular level?

Because heat is applied to milk during the industrial

preservation processes an inflammatory reaction is

triggered in the intestines. The cells alert the body

of a foreign element, or invader, to be eliminated.

To make the inside visible on the outside through reenacting

this process. Two players drink milk while

reproducing the inner invisible battle of the macrophages.

The name of the game is to not play against

each other but use the different pieces to win balance.

Temperature, proteins (processed and not processed),

sentry cells, cytokines (the chemical signals cells use

to communicate) are moved on the ‘board-table’ in

relation to their properties, reacting to each other in

the intestinal battle field. The two players have to

move their pawn to induce reactions releasing pro or

anti inflammatory signals and achieve a balance between

the two.


Glucose

NATURALLY PRESENT IN COW MILK


Milk protein

(original state)


Milk protein

(after UHT process)

THE SHAPE OF THE PROTEIN CHANGES DUE TO THE ACTION OF HEAT COMBINED WITH

GLUCOSE. THE INTERTWINED AMINO ACIDS COMPOSING THE PROTEIN UNFOLDS


Macrophage

PATROLING CELL IN CHARGE OF RECOGNIZING AND DESTROYING UNWANTED ELEMENTS.

THEY RELEASE CHEMICAL SIGNALS TO INFORM OTHER IMMUNE CELLS OF POSSIBLE

THREATS


B Lymphocyte

DEFENSE CELLS PRODUCING TARGETED ANTOBODIES IN RESPONSE TO A THREAT. THEY

CAN COMMUNICATE BETWEEN EACH OTHER AND RECEIVE INFORMATIONS FROM PATROL-

ING CELLS


Anti-inflammatory

cytokine

HORMON PRODUCED BY MACROPHAGES AFTER THEY DETECTED HARMLESS ELEMENTS.

THEY KEEP THE DEFENSES OF THE BODY TO A NORMAL ALERT LEVEL


Pro-inflammatory

cytokine

HORMON PRODUCED BY MACROPHAGES AFTER THEY DETECTED A THREAT (POTENTIAL OR

ALREADY KNOWN). THEY STIMULATE THE PRODUCTION OF NEW IMMUNE CELLS TO DE-

FEND THE BODY


Cellular communication

cytokine

HORMON PRODUCED BY IMMUNE CELLS IN RESPONSE TO A STIMULIS. THEY ALLOW THE

CELLS TO SEND SIGNALS TO OTHER THREAT TO INFLUENCE THEIR BEHAVIOR


Heat+Protein+Glucose : Maillard reaction

THE ACTION OF HEAT ON PROTEIN MIXED WITH GLUCOSE CREATES A REACTION CHANG-

ING THE SHAPE OF THE PROTEINS. WHEN THE PLAYERS HAVE COMBINED PROTEINS WITH

GLUCOSE AND ARRIVE ON A HEAT SPOT, THE REPLACE THEIR ORIGINAL PROTEIN PAWN

AND GLUCOSE PAWN WITH AN UNFOLDED PAWN. THE GLUCOSE STAYS IN THE GAME AND

THE FOLDED PROTEIN GOES AWAY


Reconnaissance of the protein by the

macrophages

THE MACROPHAGES RECOGNIZE THE PROTEINS AS ELEMENTS TO PROCESS


Absorbtion of the protein by the macrophage

THE MACROPHAGES ABSORB PROTEINS IN BOTH THEIR ORIGINEL AND MODIFIED

STATES. THEY CAN ONLY ABSORB ONE AT A TIME, THE PROTEIN PAWN GOES INSIDE THE

MACROPHAGE PAWN


Raw protein recognized as harmless : production

of anti inflammatory cytokines

THE MACROPHAGE ANALYZES THE PROTEIN AS HARMLESS : IT HAS THE NORMAL SHAPE

OF A PROTEIN. THE MACROPHAGE PAWN PRODUCES ONE ANTI-INFLAMMATORY

CYTOKINE


Heated protein recognized as a foreign element

: production of pro-inflammatory cytokines

THE MODIFIED PROTEIN IS DETECTED AS A DANGEROUS/UNUSUAL SO POTENTIALLY DAN-

GEROUS ELEMENT. TWO POSSIBILITIES : THE MACROPHAGE RELEASE A PRO INFLAMMA-

TORY CYTOKINE OR BOTH A COMMUNICATION AND PRO INFLAMMATORY CYTOKINE


Communication of the threat from macrophage

to macrophage

A MACROPHAGE RECEIVES A SIGNAL FROM ANOTHER ONE INDICATING THE PRESENCE OF

A THREAT, IN RESPONSE TO THIS SIGNAL, IT RELEASES A PRO INFLAMMATORY CYTOKINE.

IT IS POSSIBLE THAT THIS MACROPHAGE ALREADY ABOSRBED AN ORIGNAL OR MODIFIED

PROTEIN AND RELEASED THE CORRESPONDING CYTOKINE


Threat communicated from a macrophage to

a B cell

A MACROPHAGE WHICH ABSORBED A MODIFIED PROTEIN CAN SEND A COMMUNICATION

CYTOKINE TO A B CELL LOCATED IN THE LYMPH NODES


The B cells produce more pro-inflammatory

cytokine to increase the production of defense

cells by the organism

ONCE THE B CELL RECEIVED AN ALARMING SIGNAL FROM A MACROPHAGE IT RELEASES

THREE PRO INFLAMMATORY CYTOKINES


Threat communicated from one B cell to another

one to produce more pro-inflammatory

cytokines

B CELLS CAN COMMUNICATE TO EACH OTHER WITH COMMUNICATION CYTOKINES : THE B

CELL RECEIVING THE SIGNAL ALSO RELEASE THREE PRO INFLAMMATORY CYTOKINES


Destruction and further

digestion of th

protein

ONCE CYTOKINES RELEASED AND BROUGHT

TO THE CENTRE OF THE BOARD, THE PRO-

TEIN PAWN ARE TAKEN AWAY AND THE

MACROPHAGE CAN ABSORB NEW ELE-

MENTS

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