1587657 Hart&vaat jaarbeeld 2019_EN

UMCUTRECHT

UMC Utrecht

Center for

Circulatory Health

The UMC Utrecht Center for

Circulatory Health combines

all knowledge and expertise

concerning healthcare,

education and research in the

field of cardiovascular diseases.

Our mission is to reduce

the burden of cardiovascular

disease. This annual review

provides an overview of 2019.

Annual Review 2019


Facts & Figures

Outpatient clinic

In 2019, 335 unique patients

received multidisciplinary

treatment in the one-stop shop.

This is 70% more than in 2018.

Daily, the following specialties are

present in the multi disciplinary

outpatient clinic: cardiology,

vascular surgery and vascular

internal medicine.

Specialists in the following disciplines

are present occasionally and on call:

neurology, geriatrics, clinical genetics,

cardiothoracic surgery, nephrology and

hematology (amyloidosis).

Access time averages 16 days. 38% of

patients can come for a consultation

within 1 week and 75% of patients has

a multidisciplinary appointment (often

with functional examination) within

4 weeks.

Access time of new patients

Click here for the video

about Mrs Schultz van

Haegen-Hoogewerff

80

70

60

50

40

30

20

10

0

30%

20%

16%

15%

8%

7%

3%

0 - 1 8 wk

UMC Utrecht Center for Circulatory Health Annual Review 2019


Center for Circulatory Health receives

unique European accreditation

The UMC Utrecht Center for Circulatory

Health is the first center in the

Netherlands to receive accreditation

for prevention from the European

Association of Preventive Cardiology

(EAPC).This accreditation signifies

that the Center for Circulatory Health

works according to the standards and

guidelines of the European Society

of Cardiology (ESC) for primary and

secondary prevention and sports.

There are only five hospitals in

Europe with this accreditation.

Read the article

Center for Hereditary

Cardiovascular Diseases

In October 2019, Minister Bruno

Bruins (Medical Care and Sport)

extended the official recognition

of the Center for Hereditary Cardiovascular

Diseases of

UMC Utrecht by four years.

Patients, family members and

healthcare professionals can

come to this NFU Center of

Expertise for rare diseases for

expert and comprehensive care

for hereditary diseases of the

heart muscle (cardiomyopathy),

heart rhythm disorders and rare

hereditary vascular diseases.

Barbara Casadei and Hendrik Nathoe

Stijn Hazenberg,

Jan Westerink and

Hendrik Nathoe

UMC Utrecht Center for Circulatory Health Annual Review 2019


New multidisciplinary outpatient

clinic for Amyloidosis in the

Center for Circulatory Health

Marish Oerlemans

In June, cardiologist Marish Oerlemans set

up a special multidisciplinary outpatient

clinic for Amyloidosis in the Center

for Circulatory Health. In this clinic,

specialists see patients with left-ventricular

hypertrophy and heart failure that could

cause a specific form of cardiac amyloidosis.

The specialists in the outpatient clinic work

closely together with the Clinical Genetics

and Hematology departments.

Since the opening of the special outpatient

clinic last June, over 35 patients have

been seen in a multidisciplinary context.

In addition, control patients who were

checked at other outpatient clinics are also

transferred to this special outpatient clinic.

Cardio-oncology outpatient clinic

Patients with a healthy heart

may be given treatment that

damages their heart, such

as chemotherapy, which

causes heart failure. Moreover,

chemotherapy, immunotherapy

and radiation can induce about

every cardiac disorder we

know about. Given their many

comorbidities and relevant drug

interactions, these patients need

a very specific approach. In 2015,

a special outpatient clinic was

set up for the early detection of

adverse cardiovascular affects

of chemotherapy. Since its

establishment, over 800 unique

patients have come to this clinic

for consultation.

Arco Teske

Read more

UMC Utrecht Center for Circulatory Health Annual Review 2019


Facts & Figures

UCC-CVRM

Within the Utrecht Cardiovascular Cohort (UCC),

a standard cardiovascular intake based on the

applicable cardiovascular risk management

(CVRM) guideline is performed and we ask

patients for informed consent for biobank

storage and follow-up in the context of scientific

research. This has been ongoing for four years.

UCC-CVRM consent for

participation

Cumulative (n)

800

600

400

200

0

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Month

Year

2018

2019

Number of UCC-CVRM participants

according to specialty

Specialty

Requested Consent

Cardiology 1966 1156 (59%)

Cardiothoracic Surgery 3 3 (100%)

Diabetics 229 169 (74%)

Geriatrics 1362 465 (34%)

Gynecology 304 220 (72%)

Infectious diseases 80 32 (40%)

Center for Circulatory Health 4 4 (100%)

Nephrology 332 262 (79%)

Neurology 395 302 (76%)

Obstetrics 57 50 (88%)

Vascular surgery 75 62 (83%)

Vascular medicine 326 278 (85%)

Katrien Groenhof,

physician-researcher,

wins Frits de

Waard award

Before and after study

UMC Utrecht Center for Circulatory Health Annual Review 2019

1 in 3 participants has

experienced a previous

cardiovascular disease

1 in 2 participants has a high

blood pressure

1 in 5 participants has diabetes

1 in 10 participants has a high

cholesterol

1 in 5 participants has a reduced

kidney function

In a before UCC (8000 patients) - after UCC (2100 patients) study,

we compared the completeness of the cardiovascular risk profile.

We found a considerable increase in the availability of information;

in the 2013 - 2015 period, for instance, LDL cholesterol was measured

in 40% of patients, which in the 2016 - 2018 period had increased to

80% of patients.


Facts & Figures

UCC-SMART

UCC-SMART is a program for additional measurements

in healthcare and informed consent for additional

measurements, biobank storage and follow-up in the

context of scientific research for cardiovascular patients

with an increased risk of cardiovascular disease.

This program has been running for 23 years.

4157

507

1403

657

1890

2062

1119

359

1312

Diagnosis upon inclusion

Cerebrovascular disease

Peripheral vascular disease

Abdominal aortic aneurysm

Hyperlipidemia

Hypertension

Diabetes mellitus

Cardiovascular disease (other)

Pregnancy complication

Other

The total number of participants of whom we currently have a complete baseline is

13,466. The total number of people currently in active follow-up is 10,108.

The maximum number of follow-up years is 21 years, the average is 8.67.

Therapy advice in UCC-SMART:

Overweight 54%

Hyperglycemia 42%

Hypertension 28%

Hypercholesterolemia 21%

Age and gender at inclusion

in UCC-SMART

Number

3000

2000

1000

0

t/m 50 51-60 61-70 71 & up

Age catogories

Gender

male

female

SMART-MR

SMART-MR is one of the

9 cohorts participating in the

new Netherlands Consortium

of Dementia Cohorts

(NCDC), which will study the

prevention of dementia.

With a Veni grant from

ZonMw, the Netherlands

Organisation for Health

Research and Development,

Jet Vonk will study to

what extent specific

linguistic characteristics

of a neuropsychological

test (‘animal fluency’) are

related to preclinical markers

of Alzheimer’s disease.

SMART-MR is part of the new

Medea-7T cohort, which

studies micro-vascular and

microstructural damage to

the brain measured using

7- Tesla MRI.

UMC Utrecht Center for Circulatory Health Annual Review 2019


UMC Utrecht uses

unique 3D technology

in which X-rays are

replaced by light

Joost van Herwaarden

UMC Utrecht is the first hospital in

the world to use a new technology to

show guide wires and catheters using

light instead of X-rays. Since 2012,

Philips and the UMC Utrecht Center for

Circulatory Health have been working

together on the development of this

technology, and the first clinical results

are now available.

“The guide wires and catheters can

be shown in 3D without X-rays, as a

result of which they can be interpreted

more effectively, which makes surgery

easier. This is of significant added

value to patients and operating room

staff,” says vascular surgeon Joost van

Herwaarden.

UMC Utrecht Center for Circulatory Health Annual Review 2019


Eight new Associate Professors appointed

in strategic theme Circulatory Health

Janneke de Man-van Ginkel, Rieke van der Graaf, Rolf Urbanus,

Dineke Koek, Jeanine Prompers, Linda van Laake, Teun de Boer and

Saskia de Jager were appointed Associate Professor as part of

the strategic theme Circulatory Health.

Professors

As of May 1, 2019, Peter van Tintelen

has been appointed Professor of Clinical

Genetics, specifically cardiogenetics, and

Marco Alings has been appointed Professor

of Clinical Trials in Circulatory Health as of

January 1, 2020.

Peter van Tintelen

Marco Alings

UMC Utrecht Center for Circulatory Health Annual Review 2019


First PI meeting to enhance

mutual connection

The first PI meeting of the strategic

theme Circulatory Health was held on

October 17 in De Zagerij in Utrecht.

The afternoon’s objective was to

enhance mutual connection and

ownership. In addition, ideas were

exchanged on how the strategic

theme could fulfill the ambitions

for the next five years, centering on

the themes data science, clinical

trials and prevention.

UMC Utrecht Center for Circulatory Health Annual Review 2019


At the end of October, an

international committee of top

scientists visited UMC Utrecht

to evaluate our research.

Under the Standard Evaluation

Protocol (SEP) that applies to all

universities and UMCs, such a

statutory evaluation is mandatory

every six years. This evaluation

is not about the distribution of

money but about monitoring

quality. The final report is

expected in January 2020.

Mat Daemen, Rick Grobbee, Folkert Asselbergs, Cecilia Linde

and Marco Houterman.

UMC Utrecht can be proud

of its researchers

UMC Utrecht Center for Circulatory Health Annual Review 2019


Grand round

&

masterclass

visiting

Prof. Michael

S. Conte

Prof. Michael S. Conte

visited the Vascular Surgery

department and the strategic

theme Circulatory Health of

UMC Utrecht on March 4 and

5. Visiting by invitation,

Mr. Conte gave an interesting

keynote lecture and a

grand round. He also gave

a masterclass: Resolution of

Vascular Injury: Mechanisms

and Therapeutic Implications

for the members of the Jacob

Jongbloed Talent Society

and staff of UMC Utrecht.

This grand round is the first

in a series of grand rounds of

strategic theme Circulatory

Health.

Michael S. Conte and Gert Jan de Borst

UMC Utrecht Center for Circulatory Health Annual Review 2019


Education in the Center for Circulatory Health

The Center for Circulatory Health pays

a lot of attention to the development

and visibility of cardiovascular education

in the Utrecht medical and biomedical

curriculum. For example, two elective

courses were given for Bachelor’s

students of Medicine: “Cardiovascular

diseases: from cause to treatment”

and “The role of the vascular wall and

blood flow”. In addition, the Center for

Circulatory Health offers an educational

brochure for students of Medicine,

SUMMA and Biomedical Sciences. This

education brochure provides students

with an interest in circulatory health

information about cardiovascular

education in the different medical and

biomedical study programs in Utrecht

and options for internships, theses

and career.

Patients in education

“We introduce students to patients within

the master’s course ‘Cardiac Regenerative

Medicine’ , a 2- week course on research into

regenerative medicine for heart disorders,”

says Professor Suzanne Korporaal. In week 1,

the students receive lectures from researchers

about the current state of affairs within this

field of research. In week 2, the students write

a patient information letter about a specific

clinical investigation in accordance with the

guidelines of the CCMO, the Central Committee

on Research Involving Human Subjects. Prior

to the assignment we ask patients to explain to

students what they expect to read in the letter

and to share their experiences with clinical

research. We conclude the assignment with a

meeting between patients and students in a

lecture room.”

Max Groenhart

UMC Utrecht Center for Circulatory Health Annual Review 2019


New members of Jacob Jongbloed

Talent Society 2019

In 2019, 12 colleagues formed

what is already the third

generation of the Jacob

Jongbloed Talent Society (JJTS).

Together with the Education

Center, the strategic theme

Circulatory Health offers

JJTS members a customized

talent program that focuses

on personal development,

collaboration and leadership.

From left to right:

Back row: Judith van Waes, Gurbey Ocak, Niek van der Aa, Thomas Alderliesten, Martijn Froeling en Jannick Dorresteijn

Front row: Ivonne Sluijs, Elise Kessler, Monika Hollander, Heleen van der Zwaan, Jelmer Wolterink en Marish Oerlemans

UMC Utrecht Center for Circulatory Health Annual Review 2019


Public lecture: living with heart

failure clarified from four perspectives

Public lecture: lifelong care for

congenital heart defects,

from young to old

Alfred

Hagedoorn

“I am a lucky man, because care in the

Netherlands is good, I have been treated at

UMC Utrecht and have people around me

who care about me,” said Alfred Hagedoorn,

experience expert, during the public lecture

on heart failure on May 29. This lecture

of the strategic theme Circulatory Health

clarified the theme “living with heart failure”

from four perspectives.

Juul

How does a congenital heart defect, develop,

what treatments are available and what

consequences does treatment have for life

from child to adult? These were the central

themes of the public lecture “Lifelong care for

congenital heart defects” held in a comfortable

tent in the courtyard of Wilhelmina Children’s

Hospital on October 1.

Insight into new

developments during

national heart valve day

On October 26,

Harteraad and UMC

Utrecht Center for

Circulatory Health

organized a national

information day

about heart valves.

UMC Utrecht Center for Circulatory Health Annual Review 2019


Preventive exercise during Cardiovascular day on June 22

Anouk Vermeer, Steven Chamuleau

and Foeke Booy (ambassador)

On Saturday, June 22, the

UMC Utrecht Center for Circulatory

Health organized the Cardiovascular

Day in Galgenwaard stadium and

sports center in Utrecht. This day

was all about preventive exercise to

prevent cardiovascular disease or

make its consequences less serious.

A day full of interesting presentations,

fun exercise workshops and an

inspiring information market.

UMC Utrecht Center for Circulatory Health Annual Review 2019


Campaign for the prevention of cardiovascular disease:

How do you reduce the risks?

Everyone can get a cardiovascular disease. There are around 1.4 million

cardiovascular patients in the Netherlands. There are a number of risk factors

that cause someone to have a greater chance of getting a cardiovascular

disease. We are committed to reducing these risks. What can you do about it

yourself and what does UMC Utrecht do in this respect?

Click here for the video

about Jan Verheul

Jan Westerink

Frank Visseren

UMC Utrecht Center for Circulatory Health Annual Review 2019


UMC Utrecht researchers

receive Dekker grants from

Dutch Heart Foundation

Jessica van Setten Linda van Laake Pieter Vader

Researchers Jessica van Setten,

Linda van Laake and Pieter Vader

of the UMC Utrecht Center for

Circulatory Health have received a

Dekker grant from the Hartstichting,

the Dutch Heart Foundation. A total

of ten talented scientists working

for Dutch knowledge institutes

received a personal research grant.

These grants enable the scientists

to conduct innovative research into

cardiovascular diseases in the

years to come.

ZonMW grant for

Translational Research

In a translational study, a research

group will use a so-called dynamic

contrast-enhanced MRI (DCE-MRI)

to map the relationship between

leakage of the blood-brain barrier and

the development of epilepsy after

stroke in both patients and

laboratory animals.

The project is a collaboration between

UMC Utrecht (Rick Dijkhuizen, Wim

Otte) and Maastricht UMC, and

will start on January 1, 2020. The

preclinical study in Utrecht will be

conducted by Geralda van Tilborg.

UMC Utrecht Center for Circulatory Health Annual Review 2019


ERC Starting Grants

for Ynte Ruigrok and Pieter Vader

Ynte Ruigrok and Pieter

Vader received a 1.5 million

ERC Starting Grant. This

European grant is awarded to

promising researchers who

have the potential to become

independent research leaders.

ERC grant for research

into cardiovascular

diseases in women

Hester den Ruijter has received a 2 million

euro ERC Consolidator Grant for her

research into the molecular basis of arterial

calcification in women. Within the UCARE

study she examines vascular tissue and

looks at the differences between men and

women who develop atherosclerosis, which

can ultimately lead to a heart attack. In

the analyses to date, primarily male tissue

was studied. Hester and her team are now

investigating which specific female patterns

play a role in atherosclerosis.

She hopes to develop a risk test that

can better predict the development of

cardiovascular diseases in women.

Read more

UMC Utrecht Center for Circulatory Health Annual Review 2019


Facts & Figures

Strategic theme Focus Matrix

Expertise

area:

Genetics

Imaging

Patient group:

Heart

failure

Atherosclerosis

Cerebral

ischemia

Aneurysms

Clinical Epidemiology, Trials, Data Science

Global CV Health, Diversity

Prevention

High risk groups

Hypertension

Diabetes

Premature

& progressive

vasc.

disease

Chairpersons of

research tables

The strategic theme has four

research tables that meet

regularly:

Research table Heart

failure: Linda van Laake and

Frans Rutten

Research table Cerebral

ischemia: Bart van der Worp

Research table Aneurysms:

Dominique de Kleijn

Research table High risk:

diabetes/hypertension:

Wilko Spiering

Objective

For all patient groups

we focus on detection,

diagnosis, treatment and

prognosis of the disease.

By joining forces we

want to develop a strong

translational line with a

connection between basic

and clinical research and

vice versa.

UMC Utrecht Center for Circulatory Health Annual Review 2019


Asselbergs succeeds Grobbee as

chair of the strategic theme Circulatory Health

Folkert Asselbergs

Rick Grobbee

Folkert Asselbergs,

cardiologist and Professor

of Cardiovascular Genetics,

was appointed chairperson

of the strategic theme

Circulatory Health as of

August 1 by the Executive

Board. Folkert Asselbergs

succeeds Rick Grobbee,

Professor of Clinical

Epidemiology and Associate

Professor of International

Health Sciences and

Global Health.

Who is who in our

strategic theme?

Read more ‘about us’

New facilities

coordinators

The strategic theme has

appointed three facilities

coordinators: Yvonne

van der Schouw for the

theme prevention and

Charlotte Onland-Moret

and Daniel Oberski for

the theme data science.

UMC Utrecht Center for Circulatory Health Annual Review 2019


A happy and

healthy 2020!

UMC Utrecht

Center for Circulatory Health

UMC Utrecht Center for Circulatory Health Annual Review 2019

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