Re s e arch De gre e s in Ch e m is try Sch ool of Ch e m is try Ne w ...

Re s e arch De gre e s in Ch e m is try
Sch ool of Ch e m is try
Ne w cas tle Unive rs ity, UK

Sch ool of Ch e m is try
Re s e arch in th e Sch ool of Ch e m is try
Introduction...............................................................................................1
Facilitie s ....................................................................................................2
Applications ..............................................................................................3
Staff re s e arch inte re s ts .......................................................................4-25
Ch e m is try laboratorie s at Ne w cas tle .
h ttp://w w w .ncl.ac.uk /ch e m is try

1
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try
Th e Sch ool of Ch e m is try at Ne w cas tle is a vibrant ce ntre of re s e arch in
ch e m is try w ith an inte rnational re putation in a w ide range of fie lds from
catalys is to anticance r drug de s ign and m ole cular ph otonics to
nanote ch nology. W e als o h ave s trong indus trial link s w ith m ajor com panie s
including GlaxoSm ith Kline , Joh ns on-Matth e y, Proctor and Gam ble ,
Am e rs h am , Davy Proce s s Te ch nology, BAE Sys te m s , Inte l, Du Pont and
Pfiz e r.
Co laborative e ngage m e nt and m ulti-dis ciplinarity are e ncourage d, as are
link s w ith oth e r Sch ools in th e Unive rs ity and th e cros s -Faculty Re s e arch
Ins titute s . Th riving co laborations e xis t w ith co le ague s in Biology, Me dicine ,
Ch e m ical Engine e ring and Mate rials , Ce l and Mole cular Biology, Ele ctrical
Engine e ring, and Civil Engine e ring. Se ve ral s taff are as s ociate d w ith th e
Ins titute for Nanos cale Scie nce and Te ch nology
(h ttp://w w w .ncl.ac.uk /ins at/), th e North e rn Ins titute for Cance r Re s e arch
(h ttp://w w w .ncl.ac.uk /nicr/), th e Re s e arch Ce ntre for Catalys is and
Inte ns ifie d Proce s s ing (h ttp://w w w .ncl.ac.uk /catalys is /), and th e Ins titute for
Re s e arch in Environm e nt and Sus tainability
(h ttp://w w w .ncl.ac.uk /e nvironm e nt/). Re s e arch opportunitie s are available in
a l th e s e are as .
Th e Sch ool offe rs a varie ty of opportunitie s for pos tgraduate re s e arch for
th e De gre e s of Mas te r of Ph ilos oph y (MPh il) and Doctor of Ph ilos oph y
(Ph D). Th e MPh il tak e s one ye ar fu l-tim e , and th e Ph D tak e s a m inim um of
th re e ye ars fu l-tim e or five ye ars part-tim e . Th e Sch ool als o offe rs a
num be r of taugh t MSc program m e s in applie d and drug ch e m is try. W e
w e lcom e e nq uirie s and applications at any tim e .
Dr Be n H orrock s
Dire ctor of Pos tgraduate Studie s (b.r.h orrock s @ ncl.ac.uk )

Sch ool of Ch e m is try
Facilitie s
Much of th e s pe cialis t s cie ntific e q uipm e nt for ch e m is try is locate d in
individual re s e arch laboratorie s (e .g., in Mole cular Ph otonics and Ch e m ical
Nanos cie nce ).
Synth e s is
Th e re is a s tate -of-th e -art laboratory for s ynth e tic w ork and a fu l s uite of
analytical e q uipm e nt
(h ttp://w w w .ncl.ac.uk /ch e m is try/pos tgrad/facilitie s /facilitie s .h tm ).
X-ray crys ta lograph y
W e h ave tw o m ode rn are a-de te ctor diffractom e te rs capable of co le cting a
fu l s e t of X-ray diffraction data in a fe w h ours , e nabling rapid de te rm ination
of crys tal s tructure s for organic, organom e ta lic and inorganic com pounds .
For m ore de m anding s am ple s s uch as ve ry s m a l crys tals , acce s s to th e
national s ynch rotron radiation facilitie s is available .
NMR
Th e Sch ool’s W olfs on NMR s uite is h ous e d in purpos e -built accom m odation
and is e q uippe d w ith th re e h igh re s olution m ultinucle ar puls e d Fourie r
trans form NMR s pe ctrom e te rs ope rating at proton fre q ue ncie s of 300 to 500
MH z . Alm os t a l m agne tic nucle i can be s tudie d ove r a te m pe rature range of
173 to 39 3 K. A ve ry w ide range of one - and tw o-dim e ns ional e xpe rim e nts
is available and m any inve rs e de te ction proce dure s for ach ie ving h igh
s e ns itivity.
Com puting
De dicate d s e rve rs and clus te rs for q uantum ch e m ical and m ole cular
dynam ics s im ulations are available in th e Sch ool and th e re is e xce le nt
acce s s to h igh pe rform ance com puting.
h ttp://w w w .ncl.ac.uk /ch e m is try
2

3
Applications
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try
A l pos tgraduate applications s h ould be m ade via th e Unive rs ity's online
application form
h ttp://w w w .ncl.ac.uk /pos tgraduate /apply/applicationform s /
Ple as e do not print th e form and pos t it: s ubm it online . Afte r s ubm itting th e
form , you s h ould as k your re fe re e s to s e nd th e ir le tte rs of re com m e ndation
to th e adm is s ions tutor, Dr Be n H orrock s (b.r.h orrock s @ ncl.ac.uk ).
Pos tgraduate Re s e arch De gre e s , Ph D/ MPh il
Your application w i l be cons ide re d on its acade m ic m e rit s e parate ly from
q ue s tions of funding and w e are inte re s te d prim arily in th e fo low ing
inform ation:
* Your unive rs ity q ualifications , e .g., BSc - s ubje ct, clas s or GPA, trans cript.
* Re le vant w ork e xpe rie nce , e .g., w ith a ch e m ical com pany.
* A brie f s tate m e nt of your re s e arch inte re s ts - 50 w ords is s ufficie nt. Ple as e
type th is into th e w e b form .
* W h ich s upe rvis ors you w ould pre fe r to w ork w ith . Ple as e fe e l fre e to
cons ult th e s taff page s and contact pote ntial s upe rvis ors by e m ail to as k
about th e ir re s e arch inte re s ts , facilitie s and pos s ible proje cts .
Inte rnational s tude nts
Applications are ve ry w e lcom e from inte rnational s tude nts . You w i l ne e d to
provide e vide nce of your Englis h language ability be fore be ginning your
program m e , h ow e ve r th e Unive rs ity can als o offe r language training and
s upport during your program m e of s tudy.
Furth e r inform ation, including funding, for ove rs e as pos tgraduate s is
available at h ttp://w w w .ncl.ac.uk /ch e m is try/pos tgrad/inte rnational.h tm

Sch ool of Ch e m is try
My inte re s ts lie in th e fie ld of
ch e m ical X-ray crys ta lograph y and
crys tal e ngine e ring at th e inte rface
be tw e e n inorganic coordination
ch e m is try and m ate rials s cie nce of
crys ta line rare e arth com pounds .
Ne w s olve nt-poor s ynth e tic path w ays
for crys ta line m ole cular ne tw ork s are
e xplore d, com bining ionic rare e arth
com ple xe s w ith carboxylato and
am ino functionalis e d organic and
inorganic te ctons .
Furth e rm ore , crys ta line m ate rial is
te s te d agains t th e e xis te nce of oth e r
crys ta line ph as e s of th e s am e
com pound (polym orph is m ), e .g. by
Dr Ulrich Bais ch
h ttp://w w w .ncl.ac.uk /ch e m is try
4
Dipl.-Ch e m ., Unive rs ity of Tübinge n, 2001
Dr. re r. nat., Unive rs ity of Munich , 2006
Pos tdoctoral fe low , CNRS LCC, Toulous e ,
2006-7
Pos tdoctoral fe low , Unive rs ity of Bologna,
2007-8
EC Marie -Curie Fe low (IEF), Unive rs ity of
Bris tol 2008-9
Le cture r, Ne w cas tle Unive rs ity, 2009 -pre s e nt
e m ail: ulrich .bais ch @ ncl.ac.uk
Re s e arch inte re s ts : Crys tal e ngine e ring, lanth anide ch e m is try
Se le cte d Publications
[1] [Yb(C 2 O 4 ) 4 ] 5- – a ve rs atile m e tal– organic
building block for laye re d coordination
polym e rs . U. Bais ch , D. Braga,
Crys tEngCom m , 2009 , 11, 40.
[2] Re m ark able s tructural s im ilaritie s be tw e e n
organic co-crys tals and a m e tal– organic
coordination ne tw ork – ins igh ts into h ydroge n
bonde d aliph atic am m onium ch loride s . U.
Bais ch , K. Rubini, D. Braga, Crys tEngCom m ,
2008, 10, 19 39 .
us ing oth e r re action conditions or
e xpos ing th e m ate rial to diffe re nt
te m pe rature and pre s s ure . In th is
m anne r, ofte n ne w gre e n ch e m is try
m e th ods are dis cove re d for th e
s ynth e s is of nove l crys ta line and
nanocrys ta line m ate rials .
Crys tal e ngine e ring is th e de libe rate
de s ign of crys ta line com pounds
w h e re building block s are conne cte d
by inte rm ole cular inte ractions (e .g.
h ydroge n bonding).Th is m ole cular
approach offe rs h igh -yie ld, low -
e ne rgy s ynth e tic alte rnative s for
crys ta line com pouinds .
[3] Nanocrys ta line lanth anide nitride m ate rials
s ynth e s is e d by th e rm al tre atm e nt of am ido and
am m ine m e ta loce ne s : X-ray s tudie s and DFT
calculations . U. Bais ch , M. Z e une r, N. Barros ,
L. Maron, W . Sch nick , Ch e m . Eur. J., 2006, 12,
4785.
[4] H om olytic bond s tre ngth s and form ation
rate s in h alf-s andw ich ch rom ium alk yl
com ple xe s : re le vance for contro le d radical
polym e riz ation. Y. Ch am poure t, U. Bais ch , R.
Poli, L. Tang, J. L. Conw ay, K. M. Sm ith ,
Ange w . Ch e m . Int. Ed. 2008, 47, 6069 .

5
Se le cte d Publications
[1] A Donor-Acce ptor Mole cular Dyad Sh ow ing
Multiple Ele ctronic Ene rgy-Trans fe r Proce s s e s
in Crys ta line and Am orph ous State s , A. C.
Be nnis ton, G. Cople y, A. H arrim an, D. B.
Re w ins k a, R. W . H arrington, W . Cle gg, J. Am .
Ch e m . Soc. 2008, 130, 7174.
[2] Re dox Contro le d Fluore s ce nce Modulation
in a BODIPY-q uinone Dyad, A. C. Be nnis ton,
G. Cople y, K. J. E liott, R. W . H arrington, W .
Cle gg, Eur. J. Org. Ch e m . 2008, 16, 2705.
Dr Andre w C. Be nnis ton
Ph D W arw ick Unive rs ity 19 9 1
Pos tdoctoral fe low , Unive rs ity of Stras bourg
19 9 1-19 9 2; Unive rs ity of Te xas at Aus tin
19 9 2-9 4
Unive rs ity of Glas gow 19 9 4-2001
Ne w cas tle Unive rs ity 2001-pre s e nt
Dr Be nnis ton co-founde d th e Mole cular
Ph otonics Laboratory (MPL) at Ne w cas tle .
te l: 44(0)19 1 222 5706
e m ail: a.c.be nnis ton@ ncl.ac.uk
Re s e arch inte re s ts : Mole cular ph otonics
Dr Be nnis ton's re s e arch is prim arily i lum ination of th e s piropyran is not
conce rne d w ith th e de s ign and ne ce s s ary, and s e cond-ge ne ration
s ynth e s is of m ulti-com pone nt s ys te m s are in th e pipe line bas e d on
s upe rm ole cule s for fundam e ntal s e le nos piropyrans .
s tudie s in e ne rgy and/or e le ctron A re curring th e m e is th e de ve lopm e nt
trans fe r. Applications include re al- of donor-s pace r-acce ptor as s e m blie s
tim e m onitoring of nano-
containing s e ve ral ch rom oph ore s .
e nvironm e nts , pre s s ure -s e ns itive Atte ntion h as turne d to organic-bas e d
m ate rials , ph otoch rom ic m ate rials for m ate rials s uch as th e boron
data re cording, and biological dipyrrom e th e ne - oligoth ioph e ne
im aging.
dyad w h ich dis plays s ingle t-s ingle t,
Multi-com pone nt s piropyran-bas e d s ingle t-triple t and triple t-triple t e ne rgy
s ys te m s h ave be e n s ynth e s iz e d trans fe r, and als o unde rgoe s ligh t-
w h ich function as ph otoch rom ic induce d e le ctron trans fe r.
s w itch e s th at are ope ne d via an Re m ark ably, fas t e le ctron e xch ange
e xciple x inte rm e diate . In th e s e , dire ct tak e s place w ith in th e crys tal lattice .
[3] Ele ctron Exch ange in Conform ationa ly
Re s tricte d Donor-Space r-Acce ptor Dyads :
Angle De pe nde nce and Involve m e nt of Uppe rlying
Excite d State s , A. C. Be nnis ton, A.
H arrim an, P. Li, P. V. Pate l, C. A. Sam s , Ch e m .
Eur. J., 2008, 14, 1710.
[4] Ele ctron-trans fe r Re actions in th e 9 -m e s ityl-
10-m e th ylacridinium ion: Im puritie s , Triple t
State s and Infinite ly Long-live d Ch arge -s h ift
State s ? A. C. Be nnis ton, A. H arrim an, J. W .
Ve rh oe ve n, Ph ys . Ch e m . Ch e m . Ph ys . 2008,
10, 5156.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Dr Céline Cano
BSc Unive rs ity of Poitie rs , France 19 9 9
Ph D Unive rs ity of Poitie rs , France 2004
Pos tdoctoral fe low , Unive rs ity of Manch e s te r
Ne w cas tle Unive rs ity 2005-pre s e nt.
Dr Cano is curre ntly Le cture r in Me dicinal
Ch e m is try.
te l: 44(0) 19 1 222 7060
e m ail: ce line .cano@ ncl.ac.uk
Re s e arch inte re s ts : organic ch e m is try and drug dis cove ry
Drug Dis cove ry Program m e :
North e rn Ins titute of Cance r
Re s e arch
Th e North e rn Ins titute of Cance r
Re s e arch is a cros s -faculty Ins titute
w ith in th e Unive rs ity bas e d in th e
ne w Paul O’Gorm an building and th e
Be ds on Building. Our re s e arch is
focus s e d on th e dis cove ry of
inh ibitors of nove l m ole cular targe ts ,
including k e y e nz ym e s link e d w ith
re s is tance to conve ntional radiation
and ch e m oth e rapy. In co laboration
w ith Agouron/Pfiz e r, w e dis cove re d
pote nt inh ibitors of th e e nz ym e
poly(ADPribos e ) polym e ras e 1, for
Se le cte d publications
[1] M. De s age -El Murr, C. Cano-Soum i lac, B.
T. Golding, I. R. H ardcas tle , M. G.
H um m e rs om e , M. Frige rio, N. J. Curtin, K. A.
Me ne ar, C. J. Rich ards on, G. C. M. Sm ith , R.
J. Griffin. Bioorg. Me d. Ch e m . Le tt. 2008, 185,
489 0.
us e w ith DNA-dam aging anticance r
th e rapie s . Ph as e II clinical trials are
curre ntly unde rw ay.
Th e m e dicinal ch e m is try group w ork s
in co laboration w ith groups in
indus try (As tra Z e ne ca) and
acade m ia (Oxford), to dis cove r s m a lm
ole cule inh ibitors of cance r targe ts .
Curre nt targe ts include DNAde
pe nde nt prote in k inas e , oth e r PIKK
fam ily m e m be rs , th e MDM2-p53 and
MDMX-p53 prote in prote in
inte ractions , th e cyclin de pe nde nt
k inas e s , m itotic k inas e s , and nove l
targe ts in pros tate cance r.
Aus tin, B. W . Durk acz Clin. Cance r Re s . 2008,
14, 39 84.
[3] C. Cano-Soum i lac. In: Com pre h e ns ive
H e te rocyclic Ch e m is try III, volum e 4, e d. A. R.
Katritz k y. Oxford: Els e vie r, 2008, pp. 1243-
1270; pp. 1271-1304.
[4] J. J. H o lick , L. J. M. Rigore au, C. Cano-
[2] E. W i lm ore , S. L. E liot, T. Mainou-Fow le r, Soum i lac, X. Cock croft, N. J. Curtin, M.
G. Sum m e rfie ld, G. H . Jack s on, F. O'Ne il, C. Frige rio, B. T. Golding, S. Guiard, I. R.
Low e , A. Carte r, R. H arris , A. R. Pe ttit, C. H ardcas tle , I. H ick s on, M. G. H um m e rs om e e t
Cano-Soum i lac, R. J. Griffin, I. G. Cow e l, C. A. al. J. Me d. Ch e m . 2007, 50, 19 58.
h ttp://w w w .ncl.ac.uk /ch e m is try
6

7
Se le cte d Publications
[1] M. A. Carro l, J. Nairne , G. Sm ith , D. A.
W iddow s on, Radical s cave nge rs : A practical
s olution to th e re producibility is s ue in th e
fluoridation of diaryliodonium s alts , J. Fluorine
Ch e m ., 2007, 128, 127.
[2] M. A. Carro l, R. A. W ood, Arylation of
aniline s : Form ation of diarylam ine s us ing
diaryliodonium s alts , Te trah e dron, 2007, 63,
11349 .
Dr Mich ae l Carro l
Ph D Im pe rial Co le ge , London 19 9 4
Pos tdoctoral fe low , Unive rs ity of
South am pton 19 9 4-9 5;
BP Ch e m icals 19 9 6-9 7
Unive rs ity of Cam bridge 19 9 7-9 8
Im pe rial Co le ge 19 9 8-2001
Ne w cas tle Unive rs ity 2001-pre s e nt
Dr Carro l is th e founde r of Ne w Im aging Ltd.
te l: 44(0)19 1 222 7074
e m ail: m .a.carro l@ ncl.ac.uk
Re s e arch inte re s ts : s ynth e tic ch e m is try and radioph arm ace uticals
A m ajor goal is th e s ynth e s is of Th e inclus ion of s table or
natural products , in particular radiois otope s a low s th e m ole cule to
e nz ym e inh ibitors and re late d be de te cte d w ith a h igh de gre e of
com pounds . H ype rvale nt iodine accuracy, ye t re tain th e activity profile
re age nts and inte rm e diate s h ave of th e ‘natural’ com pound. Th e
provide d a rapid, ve rs atile approach curre nt focus of our re s e arch is th e
to com ple x bioactive s tructure s . W e de ve lopm e nt and com m e rcializ ation
are als o purs uing th e s e le ctive of nove l radioph arm ace uticals (e .g. 6-
incorporation, into dive rs e organic [
fram e w ork s , of e le m e nts not us ua ly
as s ociate d w ith biological s ys te m s -
typica ly fl uorine and s ilicon. A nove l
s ilicon-bas e d clas s of antim icrobial
age nts , de rive d from bioactive
ch alcone s , h as be e n de m ons trate d.
18F]FluoroDOPA) for Pos itron
Em is s ion Tom ograph y (PET).
Innovative e xpe rim e ntal proce dure s
in both batch and flow ch e m is try us e
autom ate d s ynth e tic ch e m is try
platform s , m icrofluidic s ys te m s and
m ultiple advance d analytical
te ch niq ue s .
[3] R. Yan, M. A. Carro l, Th e firs t pre paration
of a l re giois om e rs of e th yl[ 18 F]fluorobe nz oate s ,
J. Labe l. Com pd. Radioph arm ., 2008, 51, 259 .
[4] M. A. Carro l, R. Yan, L. Brich ard, D.
Solovie v, F. I. Aigbirh io, Single -s te p s ynth e s is
of N-s uccinim idyl-4-[ 18 F]fluorobe nz oate , J.
Nucl. Me d., 2008, 49 S, 29 8P.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Profe s s or W i liam Cle gg
Ph D, ScD Unive rs ity of Cam bridge
Pos tdoctoral fe low , Göttinge n, Ge rm any
Ne w cas tle Unive rs ity 19 84-pre s e nt.
Profe s s or Cle gg is als o re s pons ible for th e
ope ration of th e EPSRC National
Crys ta lograph y Se rvice at th e Diam ond
Ligh t Source in Oxfords h ire .
te l: 44(0) 19 1 222 6649
e m ail: w .cle gg@ ncl.ac.uk
My m ain re s e arch activity is X-ray
crys ta lograph y, us ing m ode rn CCDbas
e d are a-de te ctor e q uipm e nt both
in th e local laboratory (late s t
e q uipm e nt ins ta le d in 2008) and th e
Diam ond Ligh t Source in Oxfords h ire .
W e provide facilitie s for crys tal
s tructure de te rm ination to co le ague s
in Ne w cas tle , in oth e r Unive rs itie s in
th e UK and abroad, and in indus try.
My re s e arch group are als o e ngage d
in th e pre paration and
ch aracte ris ation of a varie ty of s -
block (alk ali and alk aline e arth ) m e tal
com ple xe s w ith nitroge n and oxyge n
Se le cte d publications
Re s e arch inte re s ts : X-ray crys ta lograph y
[1] Synch rotron Ch e m ical Crys ta lograph y. J.
Ch e m . Soc. Dalton Trans ., 2000, 3223.
[2] Re gios e le ctive Te tram e talation of Fe rroce ne
in a Single Re action: Exte ns ion of s -Block
Inve rs e Crow n Ch e m is try to th e d-Block .
donor ligands , particularly organic
am ine s , pyridone s , cyanuric acid and
de rivative s ; th e s e range from
m ononucle ar m ole cular com ple xe s to
ne tw ork polym e ric s tructure s .
Anoth e r re s e arch th e m e conce rns
s upram ole cular coordination
ch e m is try, particularly of
polycarboxylic acids , w ith both m aingroup
and trans ition m e tals . One -,
tw o- and th re e -dim e ns ional polym e ric
ne tw ork s h ave be e n ge ne rate d, and
s om e of th e m are m icroporous .
of th e e ffe ct of re action s toich iom e try on th e
crys ta line products form e d in th e
potas s ium – cyanurate s ys te m . Acta Crys t.
2006, B62, 79 8.
[4] Synth e s is and s tructure s of alk ali m e tal
Ange w . Ch e m . Int. Ed., 2001, 40, 39 02 (journal com ple xe s of is oph th alic acid: th e inte rplay of
front cove r).
organic s upram ole cular inte ractions and
fle xible m e tal coordination as s tructure -
[3] Stoich iom e try-de pe nde nt s tructure s : an X- dire cting factors . Crys t. Grow th De s ., 2009 , 9 ,
ray and ne utron s ingle -crys tal dffraction s tudy 1158.
h ttp://w w w .ncl.ac.uk /ch e m is try
8

9
Se le cte d Publications
[1] Synth e s is of Biaryl Diph os ph ine s via a
Re gios e le ctive Double Die ls -Alde r
Cycloaddition Elim ination Se q ue nce : Efficie nt
Ligands for th e Pa ladium -Catalyz e d Am ination
of Arom atic Brom ide s . S. Doh e rty, C. H .
Sm yth , R. W . H arrington and W . Cle gg,
Organom e ta lics , 2009 , 28, 5273.
[2] Rh odium Com ple xe s of (S)-Me -CATPH OS
and (R)-(S)-JOSIPH OS: H igh ly
Enantios e le ctive Catalys ts for th e As ym m e tric
Dr Sim on Doh e rty
Ph D Unive rs ity Co le ge , London 19 9 0
Pos tdoctoral fe low , Unive rs ity of W ate rloo,
Canada 19 9 0-19 9 2; Indiana Unive rs ity 19 9 2-
9 4;
Unive rs ity of W ale s , Sw ans e a 19 9 4-19 9 5
Ne w cas tle Unive rs ity 19 9 5-2001
Que e n’s Unive rs ity of Be lfas t 2001-2004
Ne w cas tle Unive rs ity 2004-pre s e nt
te l: 44(0)19 1 222 6537
e m ail: s im on.doh e rty@ ncl.ac.uk
Re s e arch inte re s ts : organom e ta lic ch e m is try and catalys is
Synth e s is
Our re s e arch is bas e d in th e are a of
platinum group m e tal catalys is w ith
an e m ph as is on de ve loping
innovative route s to ne w fam ilie s of
ph os ph ine s , particularly th os e bas e d
on a biaryl or biaryl-lik e arch ite cture .
W e are particularly inte re s te d in
de ve loping ne w approach e s th at us e
ine xpe ns ive building block s , th at are
ope rationa ly s traigh tforw ard, h igh ly
m odular and th at can be us e d to
cons truct arch ite ctura ly uniq ue
ligand fram e w ork s . Re ce nt
de ve lopm e nts from our group include
NUPH OS, NU-BIPH EP, KITPH OS
and CATPH OS, a l of w h ich are
com m e rcia ly available from Stre m
Ch e m ical Co.
Catalys is
W e h ave a com pre h e ns ive catalys t
te s ting program m e to e valuate th e
ne w ph os ph ine s in a range of
platinum group m e tal catalyz e d
trans form ation. An e xciting
de ve lopm e nt involve s th e s ynth e s is
and re s olution of atropos CATPH OS
diph os ph ine s , a nove l clas s of biaryllik
e diph os ph ine th at give s e e ’s in
e xce s s of 9 9 % in rh odium catalyz e d
as ym m e tric h ydroge nation.
H ydroge nation of (E)- and (Z )-β-Aryl-β-
(Acylam ino)-vinylph os ph onate s . S. Doh e rty, J.
G. Knigh t, A. L. Be l, S. El-Me nabaw e y, C. M.
Voge ls , A. De ck e n, and S. A. W e s tcott,
Te trah e dron: As ym m e try, 2009 , 20, 1437.
[3] Can a 1,3-Butadie ne Arch ite cture Com pe te
w ith its Biaryl Counte rpart in As ym m e tric
Catalys is ? Enantiopure Me -CATPH OS, A
Re m ark ably Efficie nt Ligand for As ym m e tric
H ydroge nation. S. Doh e rty, C. H . Sm yth , A.
H arrim an, R. W . H arrington and W . Cle gg,
Organom e ta lics , 2009 , 28, 888.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Dr Joh n Errington
BSc Unive rs ity of Le e ds 19 77
Ph D Unive rs ity of Le e ds 19 80
Pos tdoctral fe low , Indiana Unive rs ity, 19 80-
19 81; QMC, London, 19 82-19 84
Ne w cas tle Unive rs ity 19 84-pre s e nt.
Dr Errington w as H e ad of Sch ool (2002-
2006) and is de puty dire ctor of th e ce ntre for
catalys is and inte ns ifie d proce s s ing.
te l: 44(0) 19 1 222 6643
e m ail: joh n.e rrington@ ncl.ac.uk
Re s e arch inte re s ts : Inorganic and m e talorganic s ynth e s is
My re s e arch involve s
inorganic/m e talorganic s ynth e s is and
re activity at th e boundary be tw e e n
th e m ole cular s cale and th e s olid
s tate , w h e re e ffe cts aris ing from th e
trans ition from s m a l m ole cule s to
e xte nde d s olid s ys te m s provide
opportunitie s for advance s in
catalys is and m ate rials s cie nce .
Me tal Alk oxide s
W e h ave an inte re s t in h e te rom e ta lic
alk oxide s as s ingle -s ource
pre curs ors to fe rroe le ctric, non-line ar
optical and catalytic m ate rials .
Se le cte d publications
[1] R. J. Errington, S. S. Pe tk ar, P. S.
Middle ton, W . McFarlane , W . Cle gg, R. W .
H arrington, Dalton Trans ., 2007, 5211
Mole cular m e tal oxide ch e m is try
Polyoxom e talate s are nanos cale
m ole cular oxide s w ith a varie ty of
s h ape s , s iz e s and e le ctronic
prope rtie s . W e s tudy fundam e ntal
aggre gation and dynam ic s olution
proce s s e s us ing m ultinucle ar NMR
and m as s s pe ctrom e try.
Catalys t de ve lopm e nt
W e are e xploring w ays of trans fe rring
catalytic re actions of h e te roge ne ous
m e tal oxide s into th e s olution ph as e .
Co laborators include Joh ns on-
Matth e y, Davy Proce s s Te ch nology
and ACAL Ene rgy.
A. H oulton, L. H . Lie , S. N. Patole , Ange w .
Ch e m . Int. Ed. Eng, 2005, 44, 1254
[4] S. Doh e rty, R. J. Errington, N. H ous le y, W .
Cle gg, Organom e ta lics , 2004, 23, 2382
[2] R. J. Errington, S. S. Pe tk ar, P. S.
[5] Ge ne ral Strate gie s for Non-Aq ue ous
Middle ton, W . McFarlane , W . Cle gg, R. A. Polyoxom e talate Synth e s is . R. J. Errington, in
Coxa l, R. W . H arrington, J. Am . Ch e m . Soc. Polyoxom e talate Mole cular Scie nce , J. J.
2007, 129 , 12181
[3] R. J. Errington, S. S. Pe tk ar, B. R. H orrock s ,
Borrás -Alm e nar, E. Coronado, A. Mü le r, M. T.
Pope Eds ., Kluw e r Dordre ch t, 2003, pp 55-77.
h ttp://w w w .ncl.ac.uk /ch e m is try
10

11
Se le cte d Publications
[1] Dynam ic Com binatorial Librarie s
Cons tructe d on Polym e r Scaffolds , D. A.
Fulton, Org. Le tt. 2008, 10, 329 1.
[2] Glycoconjugate s of gadolinium com ple xe s
for MRI applications , D. A. Fulton, E. M.
Ele m e nto, S. Aim e , L. Ch aabane , M. Botta, D.
Park e r, Ch e m . Com m un. 2006, 1064.
[3] Efficie nt Re laxivity Ench ance m e nt in
De ndritic Gadolinium Conjugate s : Effe ctive
Dr David Fulton
BSc Strath clyde Unive rs ity, 19 9 6
Ph D Unive rs ity of California Los Ange le s ,
2001
Quintile s 2002
Pos tdoctoral fe low , Unive rs ity of Durh am ,
2003-2005
Ne w cas tle Unive rs ity 2006-pre s e nt
Dr Fulton is an RCUK Acade m ic Fe low in
Nanos cie nce .
te l: 44(0)19 1 222 7065
Re s e arch inte re s ts : Organic s upram ole cular and polym e r ch e m is try
W e are organic ch e m is ts w ith
inte re s ts in s upram ole cular and
polym e r ch e m is try.
Polym e r-Scaffolde d Dynam ic
Com binatorial Librarie s
Can w h o ly s ynth e tic m acrom ole cule s
m im ic th e m ole cular re cognition and
catalytic prope rtie s of natural
prote ins ? W e are applying ide as from
th e fie ld of dynam ic com binatorial
ch e m is try to addre s s th is ch a le nge .
Dynam ic Covale nt Polym e r-Bas e d
Nanos tructure s
Synth e tic organic and polym e r
ch e m is trie s are be ing us e d to
pre pare nove l polym e r building
block s w ith th e ability to s e lfas
s e m ble into s tructure s , w h ich
pos s e s s re s pons ive and adaptive
prope rtie s . W e are us ing dynam ic
covale nt bonds to facilitate th e s e lfas
s e m bly proce s s .
Dynam ic Covale nt Se lf-As s e m bly
W e are applying dynam ic covale nt
ch e m is try, w h ich us e s re ve rs ible
covale nt bond-form ing re actions , to
as s e m ble de s igne d organic building
block s , to form e xotic m ole cule s w ith
unus ual arch ite cture s .
Motional Coupling in Me dium Mole cular W e igh t
Conjugate s , D. A. Fulton, M. O'H a loran, D.
Park e r, K. Se nanayak e , M. Botta, S. Aim e ,
Ch e m . Com m un. 2005, 474.
[4] Probing polyvale ncy in artificial s ys te m s
e xh ibiting m ole cular re cognition, D. A. Fulton,
S. J. Cantri l, J. F. Stoddart, J. Org. Ch e m .
2002, 67, 79 68.
[5] Ne oglycoconjugate s bas e d on cyclode xtrins
and calixare ne s , D. A. Fulton, J. F. Stoddart,
Bioconjug. Ch e m . 2001, 12, 655.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Profe s s or Be rnard Golding
BSc Unive rs ity of Manch e s te r, 19 62
Ph D Unive rs ity of Manch e s te r, 19 65
Pos tdoctoral fe low , ETH 19 65-67
Ne w cas tle Unive rs ity 19 83-pre s e nt.
Profe s s or Golding is a s e nior re s e arch
inve s tigator and is s cie ntific dire ctor of th e
com pany Ne w Ch e m Te ch nologie s .
te l: 44(0) 19 1 222 6647
e m ail: b.t.golding@ ncl.ac.uk
Re s e arch inte re s ts : Organic, m e dicinal and biological ch e m is try
Enz ym e Me ch anis m s
Es pe cia ly unus ual or ‘im pos s ible ’
re actions including th os e for w h ich
radicals are inte rm e diate s (e .g.
coe nz ym e B12-de pe nde nt re actions ,
flavin-de pe nde nt de h ydratas e s ,
h ydroge nas e s ).
Mole cular Toxicology
Us e of cob(I)alam in as an analytical
tool in toxicology; pos s ible role for
vitam in B12 as a de fe nce m e ch anis m
agains t e le ctroph ilic xe nobiotics ;
m ole cular m e ch anis m s in
carcinoge ne s is (e s pe cia ly be nz e ne ,
is opre ne and ch loropre ne ).
Se le cte d publications
[1] P. Frie drich , D. J. Darle y, B. T. Golding, W .
Buck e l, Th e com ple te s te re och e m is try of th e
e nz ym atic de h ydration of 4-h ydroxybutyryl
coe nz ym e A to crotonyl coe nz ym e A. Ange w .
Ch e m . Int. Ed. 2008, 47, 3254.
[2] W . Buck e l, C. Kratk y, B. T. Golding,
Stabilis ation of m e th yle ne radicals by
cob(II)alam in in coe nz ym e B12 de pe nde nt
m utas e s , Ch e m . Eur. J., 2006, 12, 352.
Anticance r Drug De s ign
Rational de s ign of ne w anticance r
age nts bas e d on th e m ole cular
path ology of cance r; prote in targe ts
include DNA-prote in k inas e , cyclin
de pe nde nt k inas e s and m dm 2/p53.
Synth e tic Organic Ch e m is try
Synth e s is of biologica ly active
m ole cule s including nove l am ino
acids and polyam ine s ; ne w
m e th odology including prote cting
groups ; us e of trifluoroe th anol as a
m agic s olve nt in s ynth e s is .
h ttp://w w w .ne w ch e m te ch nologie s .com
[3] R. J. Griffin, A. H e nde rs on, N. J. Curtin, A.
Ech alie r, J. A. Endicott, I. R. H ardcas tle , D. R.
Ne w e l, M. E. Noble , L. Z . W ang, B. T. Golding.
Se arch ing for cyclin-de pe nde nt k inas e
inh ibitors us ing a ne w variant of th e Cope
e lim ination. J. Am . Ch e m . Soc. 2006, 128,
6012.
[4] A. J. Pie rik , T. Graf, L. Pe m be rton, B. T.
Golding, J. Re te y. But-3-e ne -1,2-diol: A
m e ch anis m -bas e d active s ite inh ibitor for
coe nz ym e B-12-de pe nde nt glyce rol
de h ydratas e , Ch e m BioCh e m , 2008, 9 , 2268.
h ttp://w w w .ncl.ac.uk /ch e m is try
12

13
Se le cte d Publications
[1] C. Rie dinge r, J. A. Endicott, S. J. Ke m p, L.
A. Sm yth , A. W ats on, E. Vale ur, R. J. Griffin, B.
T. Golding, I. R. H ardcas tle , M. E. M. Noble , J.
M. McDonne l. Analys is of Ch e m ical Sh ift
Ch ange s Re ve als th e Binding-m ode s of
Is oindolinone Inh ibitors of th e MDM2-p53
Inte raction. J. Am . Ch e m . Soc. 2008, 130,
16038.
[2] E. W i lm ore , S. L. E liott, T. Mainou-Fow le r,
G. P. Sum m e rfie ld, G. H . Jack s on, C. Low e , N.
Profe s s or Roge r Griffin
BSc Ph arm acy, Unive rs ity of Ports m outh ,
19 81
Ph D, As ton Unive rs ity, 19 85
Ne w cas tle Unive rs ity 19 9 0-pre s e nt
Profe s s or Griffin is a m e m be r of th e
North e rn Ins titute for Cance r Re s e arch
(NICR)
te l: 44(0)19 1 222 859 1
e m ail: r.j.griffin@ ncl.ac.uk
Re s e arch inte re s ts : Me dicinal ch e m is try & anticance r drug dis cove ry
Th e de s ign, s ynth e s is and biological
e valuation of antitum our drugs acting
on nove l targe ts as s ociate d w ith th e
m ole cular path ology of cance r. Th e
de ve lopm e nt of age nts w ith th e
pote ntial to s yne rgis e th e antitum our
activity of e s tablis h e d drugs by
m odulating re s is tance proce s s e s
(re s is tance m odifying age nts ).
Anticance r Drug Dis cove ry
Th e Me dicinal Ch e m is try Group is a
core divis ion of th e Cance r Re s e arch
UK Drug Dis cove ry Program m e of
th e North e rn Ins titute for Cance r
Re s e arch (NICR) at Ne w cas tle
Unive rs ity. Th e ove ra l obje ctive s of
th e Group are th e de s ign, s ynth e s is
and biological e valuation of ne w
antitum our age nts . In addition to th e
de s ign of com pounds dire cte d at
targe ts ide ntifie d from an
unde rs tanding of th e m ole cular
path ology of cance r, th e de ve lopm e nt
of age nts (re s is tance -m odifie rs ) th at
pote ntiate th e antitum our activity of
e xis ting drugs by m odulating a
re s is tance m e ch anis m is a m ajor
re s e arch th e m e . Th e NICR Me dicinal
Ch e m is try Group h as e xte ns ive
co laborations w ith co le ague s w ith in
th e Sch ool of Ch e m is try.
Bow n, A. Carte r, A. Pe ttitt, C. Cano-Soum i lac,
R. J. Griffin, I. Cow e l, C. A. Aus tin, B. W .
Durk acz . DNA-de pe nde nt prote in k inas e is a
th e rape utic targe t and an indicator of poor
prognos is in B-ce l ch ronic lym ph ocytic
le uk ae m ia. Clin. Cance r Re s . 2008, 14, 39 84.
[3] O. R. Barbe au, R. J. Griffin, I. R.
H ardcas tle , G. C. M. Sm ith , C. Rich ards on, W .
Cle gg, R. W . H arrington, B. T. Golding.
Quinolinone and pyridopyrim idinone inh ibitors
of th e DNA-de pe nde nt prote in k inas e (DNA-
PK). Org. Biom ol. Ch e m . 2007, 5, 2670.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Dr Mich ae l H a l
MCh e m , Unive rs ity of Oxford, 19 9 9
DPh il, Unive rs ity of Oxford, 2003
Pos tdoctoral fe low , Unive rs ity Co le ge
Dublin, Ire land, 2004-5;
École Supérie ure de Ph ys iq ue e t de Ch im ie
Indus trie le s , Paris , 2006.
Ne w cas tle Unive rs ity 2007-pre s e nt.
Dr H a l als o runs our MSc in Drug Ch e m is try.
te l: 44(0) 19 1 222 7321
e m ail: m .h a l@ ncl.ac.uk
Re s e arch inte re s ts : Organic Synth e s is and Marine Natural Products
Synth e s is of Natural Products
Curre nt total s ynth e s is targe ts are
bas e d on th e pyrrole -im idaz ole
alk aloids , a large fam ily of com ple x
natural products found in m arine
s ponge s . W e are inve s tigating nove l
Die ls -Alde r initiate d cas cade
re actions as fle xible route s for th e
s te re os e le ctive s ynth e s is of th e core
s tructure s of th e s e com pounds .
Synth e tic Me th odology via
Organoe le m e nt Ch e m is try
W e are curre ntly de ve loping a ne w
m e th od for th e rapid s ynth e s is of α,βuns
aturate d δ lactone s (a com m on
Se le cte d publications
[1] V. Druais , M. J. H a l, C. Cors i, S. V.
W e nde born, C. Me ye r, J. Cos s y. A Conve rge nt
Approach tow ards th e C 1 – C 11 Subunit of
Ph os lactom ycins and Form al Synth e s is of
Ph os lactom ycin B. Org. Le tt. 2009 , 11(4), 9 35.
[2] J. Robe rts on, M. J. H a l, S. P. Gre e n.
Ste re os pe cific α-(m e th yl)a lylation of
h ydroxyalde h yde s by s ilatropic e ne cyclis ation.
Te trah e dron 2009 , 65(28), 5541.
cons titue nt of polyk e tide natural
products ) us ing e nantios e le ctive
Mannich re actions com bine d w ith
cum m ulate d ph os ph orous ylide
ch e m is try.
Is olation of Ne w Bioactive Natural
Products
W e are w ork ing w ith s taff from th e
Sch ools of Biology and Marine
Scie nce and Te ch nology to ide ntify
ne w bioactive (antibacte rial and
anticance r) natural products de rive d
from bacte ria is olate d from de e p s e a
s e dim e nts and tropical m arine
s ponge s .
[3] A. Loude t, R. Bandich h or, K. Burge s s , A.
Palm a, S. O. McDonne l, M. J. H a l, D.
O'Sh e a, B,O-Ch e late d Az adipyrrom e th e ne s
as Ne ar-IR Probe s . Org. Le tt. 2008, 10, 4771.
[4] J. Robe rts on, S. P. Gre e n, M. J. H a l, A. J.
Tyrre l, W . P. Uns w orth , Furth e r s tudie s on
s ilatropic carbonyl e ne cyclis ations : βcrotyl(diph
e nyl)s ilyloxy alde h yde s ubs trate s ;
s ynth e s is of 2-de oxy-2-C-ph e nylh e xos e s . Org.
Biom ol. Ch e m . 2008, 6, 2628.
h ttp://w w w .ncl.ac.uk /ch e m is try
14

15
Th e North e rn Ins titute of Cance r
Re s e arch is a cros s -faculty Ins titute
w ith in th e Unive rs ity bas e d in th e
ne w Paul O’Gorm an building and th e
Be ds on Building. Synth e tic organic
and m e dicinal ch e m is try form th e
back bone of th e drug dis cove ry
proje cts w ith in th e NICR. Our
re s e arch is focus s e d on th e
dis cove ry of inh ibitors of nove l
m ole cular targe ts w ith in cance r,
including k e y e nz ym e s link e d w ith
re s is tance to conve ntional radiation
and ch e m oth e rapy. One proje ct, in
co laboration w ith Agouron/Pfiz e r, le d
Se le cte d Publications
[1] F. March e tti, K. L. Sayle , J. Be ntle y, A. H .
Calve rt, W . Cle gg, N. J. Curtin, J. A. Endicott,
B. T. Golding, R. J. Griffin, K. H agge rty, R. W .
H arrington, V. Me s guich e , D. R. Ne w e l, M. E.
M. Noble , R. J. Pars ons , D. J. Pratt, L. Z .
W ang, I. R. H ardcas tle , Org. Biom ol. Ch e m .
2007, 1577.
[2] J. J. H o lick , Laure nt J. M. Rigore au, Ce line
Cano-Soum i lac, X. Cock croft, N. J. Curtin,
Mark Frige rio, Be rnard T. Golding, S. Guiard,
Dr Ian H ardcas tle
BSc Bris tol Unive rs ity, 19 87
Ph D Manch e s te r Unive rs ity, 19 9 0
Pos tdoctoral fe low , Ins titute of Cance r
Re s e arch , 19 9 0-19 9 9
Ne w cas tle Unive rs ity 19 9 9 -pre s e nt
Dr H ardcas tle is a m e m be r of th e North e rn
Ins titute for Cance r Re s e arch (NICR)
te l: 44(0)19 1 222 59 34
e m ail: i.r.h ardcas tle @ ncl.ac.uk
Re s e arch inte re s ts : Me dicinal ch e m is try and drug dis cove ry
th e e nz ym e poly(ADPribos e )
polym e ras e 1 (PARP 1), for us e w ith
DNA-dam aging anticance r th e rapie s .
Ph as e II clinical trials are curre ntly
unde rw ay w ith a PARP 1 inh ibitor
from th is program m e .
Th e m e dicinal ch e m is try group w ork s
in co laboration w ith groups in
indus try and acade m ia, to dis cove r
s m a l-m ole cule inh ibitors of cance r
targe ts and to find th e rapie s for
cance r w h ich can be us e d to tre at
patie nts .
h ttp://w w w .ncl.ac.uk /nicr
to th e dis cove ry of pote nt inh ibitors of
Ian R. H ardcas tle , Ian H ick s on, Marc G.
H um m e rs one , Ke ith A. Me ne ar, N. M. B.
Martin, Ian Matth e w s , David R. Ne w e l, Rach e l
Ord, Caroline J. Rich ards on, G. C. M. Sm ith ,
R. J. Griffin J. Me d. Ch e m . 2007, 50, 19 58.
[3] I. R. H ardcas tle , S. U. Ah m e d, H . Atk ins , G.
Farnie , B. T. Golding, R. J. Griffin, S. Guye nne ,
C. H utton, P. Kä lblad, S. J. Ke m p, M. S.
Kitch ing, D. R. Ne w e l, S. Norbe do, J. S.
North e n, R. J. Re id, K. Saravanan, H . M. G.
W i le m s , J. Lune c, J. Me d. Ch e m . 2006, 49 ,
6209 .
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try 16
Profe s s or Anth ony H arrim an
As s is tant Dire ctor, Royal Ins titution of Gre at
Britain (London) 19 78-88
Dire ctor, Ce nte r for Fas t Kine tics Re s e arch ,
Th e Unive rs ity of Te xas at Aus tin, 19 88-19 9 5
Unive rs ité Louis Pas te ur de Stras bourg 19 9 5-
2000
Ne w cas tle Unive rs ity 2000-pre s e nt
Co-founde r, Mole cular Ph otonics Laboratory
Te l: + 44 (0)19 1 222 8660
E-m ail: Anth ony.h arrim an@ ncl.ac.uk
Se le cte d publications
Re s e arch inte re s ts : Mole cular ph otoph ys ics
Ene rgy Trans fe r
Th e Förs te r th e ory w ork s w e l
provide d th e s e paration dis tance
gre atly e xce e ds th e s um of th e
m ole cular radii for donor and
acce ptor. W h e n th e re actants are
clos e ly s pace d and link e d via an
organic conne ctor, it is com m on to
find th at De xte r-type e le ctron
e xch ange com ple m e nts Förs te r-type
e ne rgy trans fe r and Förs te r th e ory
cannot be applie d. W e de s ign and
s tudy clos e ly-s pace d m ole cular
dyads pos s e s s ing rigid and w e lde
fine d ge om e trie s w h e re Förs te r
th e ory can be te s te d.
[1] R. Z ie s s e l, M. A. H . Alam iry, K. J. E liott, A.
H arrim an, Ange w . Ch e m . Int. Ed., 2009 , 48,
2772.
[2] F. Odobe l, M. Se ve rac, Y. Pe le grin, E.
Blart, C. Fos s e , C. Canniz z o, C. R. Maye r, K.
J. Eliott, A. H arrim an, Ch e m . Eur. J. 2009 , 15,
3130.
[3] A. H arrim an, L. J. Ma lon, R. Z ie s s e l, Ch e m .
Eur. J. 2008, 14, 11461.
Ph otoch rom ic m ate rials
Our w ork in th is are a is bas e d on th e
de s ign of ne w ph otoch rom ic s ys te m s
th at unde rgo an ultrafas t ge om e try
ch ange unde r puls e d ligh t e xcitation.
Com putational ch e m is try
Our w ork s e e k s an im prove d
unde rs tanding of h ow pote ntial
e ne rgy lands cape s e volve as k e y
parts of a m ole cule unde rgo
trans lational m otion. Such m ole cular
(or fluore s ce nt) rotors can be us e d to
m onitor frictional force s be tw e e n th e
rotor and th e s urrounding
e nvironm e nt.
[4] A. C. Be nnis ton, A. H arrim an, P. Y. Li, P. V.
Pate l, C. A. Sam s , Ch e m . Eur. J. 2008, 14,
1710.
[5] H . J. Van Ram e s donk , B. H . Bak k e r, M. M.
Groe ne ve ld, J. W . Ve rh oe ve n, B. D. A le n, J.
P. Ros tron, A. H arrim an, J. Ph ys . Ch e m . A
2006, 110, 13145.
[6] A. H arrim an, G. Iz z e t, R. Z ie s s e l, J. Am .
Ch e m . Soc. 2006, 128, 10868.
h ttp://w w w .ncl.ac.uk /ch e m is try

17
Iron-Sulfur-Bas e d Clus te rs
Fe -S-bas e d clus te rs are found in
m any m e ta loe nz ym e s , w h e re th e y
play role s as dive rs e as : e le ctrontrans
fe r m e diators ; iron s e ns ors and
th e s ubs trate binding s ite s in re dox
and non-re dox e nz ym atic re actions .
W e are inve s tigating th e re action
m e ch anis m s of s ynth e tic Fe -S-bas e d
clus te rs . Th e binding of acid
ch loride s to th e clus te r can be
de te cte d and th e w ay in w h ich th e
acid ch loride binds s h ow s s om e
unus ual ch aracte ris tics w h ich could
Se le cte d Publications
[1] As s e m bly of H e te rom e ta lic Clus te rs and
Coordination Polym e rs by Com bining Mo-S-
Bas e d Clus te rs w ith Mn 2+ , P. Lin, W . Cle gg, R.
W . H arrington, R. A. H e nde rs on, A. J. Fle tch e r,
J. Be l, K. M. Th om as , Inorg. Ch e m ., 2006, 45,
4284.
[2] Me ch anis m of th e Re actions of Synth e tic
Fe -S-Bas e d Clus te rs w ith Ph COCl: Para le l
Path w ays Involving Fre e and Coordinate d
Th iolate as Nucle oph ile s . K. Bate s , L. Joh ns on
Profe s s or Rich ard H e nde rs on
BSc Unive rs ity Co le ge London, 19 73
Ph D Unive rs ity Co le ge London, 19 76
Proje ct Le ade r, Nitroge n Fixation Laboratory,
19 79 -19 9 9
Ne w cas tle Unive rs ity 19 9 9 -pre s e nt
Profe s s or H e nde rs on w as th e firs t re cipie nt
of th e RSC Aw ard in Inorganic Re action
Me ch anis m s .
te l: 44(0)19 1 222 6636
e m ail: r.a.h e nde rs on@ ncl.ac.uk
Re s e arch inte re s ts : Inorganic m e ch anis m s and biom im e tic ch e m is try
inte ractions of s ubs trate s w ith
clus te rs .
Activation of Sm a l Mole cule s
Binding and activation of s m a l
m ole cule s at e le ctron-rich m e tal s ite s
h as be e n a long-te rm re s e arch
inte re s t, e s pe cia ly th e protonation
ch e m is try of coordinate d N2 , RNC,
RCN, N -
3 , CN- , uns aturate d
h ydrocarbons and h ydride s . Curre nt
s tudie s are focus s ing on th e
protonation of coordinate d th iolate
de rivative s bound to a {Ni(triph os )}
h ave broade r ram ifications in te rm s of
2+
s ite , w ith an aim to m e diate and
control long range proton trans fe rs .
and R. A. H e nde rs on. Inorg. Ch e m ., 2006, 45,
9 423.
[3] Rate s of Proton trans fe r to Fe -S-Bas e d
Clus te rs : Com paris on of Clus te rs containing
{MFe (µ 2 -S) 2 } n+ and {MFe 3 (µ 3 -S) 4 } n+ (M =
Fe , Mo or W ) Core s . K. Bate s , B. Garre tt, R. A.
H e nde rs on, Inorg. Ch e m ., 2007, 46, 11145.
[4] Me ch anis m of Single Me tal Exch ange in
Re actions of [M 4 (SPh ) 10 ] 2- (M=Z n or Fe ) w ith
CoX 2 (X=Cl or NO 3 ) or Fe Cl 2 . V. Autis s ie r, R.
A. H e nde rs on, Inorg. Ch e m ., 2008, 47, 639 3.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Dr Le e H igh am
Ph D Unive rs ity of Eas t Anglia, 2000
Pos tdoctoral fe low , BP & Unive rs ity of
Bris tol, 2000-2002; Rh odia & UoB 2002-2003
Marie Curie Re s e arch Fe low , UCD 2003-
2006
Ne w cas tle Unive rs ity 2006-pre s e nt
Dr H igh am is an EPSRC Care e r
Acce le ration Fe low 2009 -2014.
te l: 44(0) 19 1 222 5542
e m ail: le e .h igh am @ ncl.ac.uk
Re s e arch inte re s ts : Organoph os ph orus ch e m is try
Ph os ph orus com pounds play k e y
role s in are as s uch as bioch e m is try,
catalys is , s e m iconductors and
m ilitary te ch nology.
Me dicinal Ch e m is try
W e co laborate w ith Oxford to de s ign
fluore s ce nt, cance r ce l-s pe cific
radioph arm ace uticals and w ith our
Me dical Sch ool to s tudy bone -m ak ing
ce ls by s taining th e ir organe le s .
As ym m e tric Catalys is
W e pre pare ligands incorporating
planar, axial or P-s te re oge nic ch irality
and be nch m ark th e m .
Se le cte d publications
[3] P-ch iroge nic ph os ph ine s . MOP/diPAMP
[1] A re -e valuation of th e e le ctroph ilic h ybrids , th e ir oxide crys tal s tructure s , re duction
s ubs titution re actions of th e Ram ire z ylide , L. J. s tudie s and alte rnative s ynth e s e s , L. J.
H igh am , J. Muldoon, P. G. Ke ly, D. M. Corr, H . H igh am , E. F. Clark e , H . Mue le r-Bunz , D. G.
Mue le r-Bunz , D. G. Gilh e any, J. Org. Ch e m ., Gilh e any, J. Organom e t. Ch e m ., 2005, 69 0,
2007, 72, 8780.
211.
[2] Tam ing a functional group: Cre ating air-
s table , ch iral prim ary ph os ph ane s , R. M. H ine y,
L. J. H igh am , H . Mue le r-Bunz , D. G. Gilh e any,
Ange w . Ch e m . Intl. Ed., 2006, 45, 7248.
Organoph os ph orus Ch e m is try
Our pione e ring w ork h as found ch iral
prim ary ph os ph ine s th at are air
s table , th e ram ifications m e aning
m ole cular de s ign could re nde r
im portant indus trial proce s s e s m uch
s afe r.
Mate rials & Surface Te ch nology
W ith Im pe rial Co le ge and our
ch e m ical e ngine e rs w e h ave grafte d
ph os ph orus onto Si ch ips ,
s ynth e s is e d h igh ly conjugate d
ph os ph ole s for optoe le ctronics and
ph os ph ino am ino acids w h ich inte ract
w ith biom ine ral s urface s .
[4] W ate r-s oluble h ydroxyalk ylate d ph os ph ine s :
e xam ple s of th e ir diffe ring be h aviour tow ard
ruth e nium and rh odium , L. J. H igh am , M. K.
W h ittle s e y, P. T. W ood, Dalton Trans ., 2004,
4202.
h ttp://w w w .ncl.ac.uk /ch e m is try
18

19
Se le cte d Publications
[1] S. Prune anu, S. A. Farh a Al-Said, L. Dong,
T. A. H o lis , M. A. Galindo, N. G. W righ t, A.
H oulton, and B. R. H orrock s , Adv. Func. Mat.
2008, 18, 2444.
[2] Y. Ch ao, L. Si le r, S. Kris h nam urth y, P. R.
Coxon, U. Bange rt, M. Gas s , L. Kje ldgaard, S.
N. Patole , L. H . Lie , N. O’Farre l, T. A. Als op, A.
H oulton and B. R. H orrock s , Nature Nanote ch .
2007, 2, 486.
Dr Be njam in H orrock s
BSc Im pe rial Co le ge , London 19 88
Ph D Im pe rial Co le ge , London 19 9 2
Pos tdoctoral fe low , Unive rs ity of Te xas at
Aus tin 19 9 2-9 4
Ne w cas tle Unive rs ity 19 9 4-pre s e nt
Dr H orrock s is th e Pos tgraduate Adm is s ions
Tutor and th e Dire ctor of Pos tgraduate
Studie s for Ch e m is try.
te l: 44(0)19 1 222 5619
e m ail: b.r.h orrock s @ ncl.ac.uk
Re s e arch inte re s ts : Nanos cie nce and nanote ch nology
Curre nt proje cts focus on DNAte
m plate d nanow ire s , s ilicon
q uantum dots , organic m onolaye rs
on s ilicon and various type s of probe
m icros copy (AFM, EFM, SECM).
DNA-te m plate d nanow ire s
W e are us ing DNA as a te m plate on
w h ich to de pos it conductive m ate rials
(m e tals , s e m iconductors , conductive
polym e rs ) to pre pare nanom e tre -
th ick ne s s w ire s (nanow ire s ) [1].
Silicon q uantum dots
Stable s ilicon nanocrys tals can be
pre pare d by a route th at com bine s
e le ctroch e m ical e tch ing of s ilicon
w afe r w ith h ydros ilation of alk e ne s
[2]. W e are inve s tigating th e ir us e as
intrace lular s pe ctros copic probe s [3].
Monolaye rs on s ilicon s urface s
W e h ave be e n co laborating w ith
Profe s s or Andre w H oulton’s group to
de ve lop m e th ods for th e form ation of
organic m onolaye rs at s ilicon w afe rs
and porous s ilicon. Curre nt activitie s
include th e ge ne ration of prote in and
DNA-bas e d s tructure s and
inve s tigations of th e m onolaye r
s tructure , prope rtie s and form ation
m e ch anis m [4,5].
[3] N. H . Als h arif, C. E. M. Be rge r, S. S.
Varanas i, Y. Ch ao, B. R. H orrock s , H . K. Datta,
Sm a l, 2009 , 5, 221.
[4] C. Roge ro, B. T. Ch affe y, E. Mate o-Marti, J.
M. Sobrado, B. R. H orrock s , A. H oulton, J. H .
Lak e y, C. Brione s and J. A. Martin-Gago, J.
Ph ys . Ch e m . C 2008, 112, 9 308.
[5] M. W oods , S. Carls s on, Q. H ong, S. N.
Patole , L. H . Lie , A. H oulton, and B. R.
H orrock s , J. Ph ys . Ch e m . B 2005, 109 , 24035.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Profe s s or Andre w H oulton
BSc Unive rs ity of Es s e x, 19 85
Ph D Unive rs ity of Es s e x, 19 89
Pos tdoctoral fe low , Im pe rial Co le ge
London, 19 9 2-19 9 4
Ne w cas tle Unive rs ity 19 9 4-pre s e nt.
Profe s s or H oulton is dire ctor of th e ch e m ical
nanos cie nce laboratory.
te l: 44(0) 19 1 222 6262
e m ail: andre w .h oulton@ ncl.ac.uk
Bottom -up and s e lf-as s e m bly
m e th ods of s ynth e s is
W e are e xploring m e th ods for th e
fabrication of functional s ys te m s
us ing, s o-ca le d, bottom -up m e th ods .
Th is include s de ve loping s ynth e tic
ch e m is try for th e m ole cular
functionalis ation of s ilicon s urface s
and m ole cular com ple xe s capable of
s e lf-organis ation and s e le ctive
binding.
Nanom ate rials pre paration and
ch aracte ris ation
Confining m ate rials to th e nanom e tre
s cale can h ave profound e ffe cts on
Se le cte d publications
Re s e arch inte re s ts : Ch e m ical as pe cts of nanos cie nce
[1] DNA-bas e d route s to s e m iconducting
nanom ate rials , A. H oulton, A. R. Pik e , M. A.
Galindo, B. R. H orrock s . Ch e m . Com m un.,
2009 , 179 7-1806.
[2] Fe rroce nyl-Modifie d DNA: Synth e s is ,
Ch aracte riz ation and Inte gration w ith
Se m iconductor Ele ctrode s , A. R. Pik e , L. C.
Ryde r, B. R. H orrock s , W . Cle gg, B. A.
Conno ly, A. H oulton, Ch e m . Eur. J. 2004, 11,
344.
th e ir be h aviour including ch ange s to
th e ir ph ys ical and ch e m ical
prope rtie s . W e inve s tigate a range of
nano-laye rs , -w ire s and -particle s
w ith particular inte re s t in th e
e le ctronic and e le ctrical prope rtie s .
Mate rials ch e m is try w ith DNA
W e h ave m ajor inte re s ts in th e us e of
DNA, and its com pone nts , as a bas is
for ne w m ate rials . Th e s e range from
s m a l m ole cule com ple xe s w h ich
provide inform ation about
fundam e ntal as pe cts of m e tal
ion… DNA inte ractions to DNA-bas e d
m ole cular w ire s .
[3] Synth e s is , Manipulation and Conductivity of
Supram ole cular Polym e r Nanow ire s , L. Dong,
T. H o lis , Ste ve n Fis h w ick B. A. Conno ly N. G.
W righ t, B. R. H orrock s , A. H oulton. Ch e m . Eur.
J. 2007, 13, 822.
[4] DNA On Silicon De vice s : On-Ch ip
Synth e s is , H ybridiz ation, and Ch arge Trans fe r,
A. R. Pik e , L. H . Lie , R. A. Eagling, L. C.
Ryde r, S. N. Patole , B. A. Conno ly, B. R.
H orrock s , A. H oulton, Ange w . Ch e m ie Intl. Ed.
2002, 41(4), 617.
h ttp://w w w .ncl.ac.uk /ch e m is try
20

21
Se le cte d Publications
[1] An intram ole cularly bas e -s tabiliz e d
diph os ph age rm yle ne and tw o unus ual
ge rm anium (II) ate com ple xe s : a s tructural,
NMR and DFT s tudy. K. Iz od, W . McFarlane , B.
A le n, W . Cle gg, R. W . H arrington,
Organom e ta lics 2005, 24, 2157.
[2] H e avie r alk ali m e tal com ple xe s of a
ph os ph ine -borane -s tabiliz e d carbanion. K.
Iz od, C. W i ls , W . Cle gg, R. W . H arrington,
Organom e ta lics 2006, 25, 5326.
Dr Ke ith Izod
BSc Que e n Mary Co le ge , London 19 87
Ph D Que e n Mary Co le ge , London 19 9 1
Pos tdoctoral fe low , Unive rs ity of Sus s e x
19 9 3-9 5
Ne w cas tle Unive rs ity 19 9 6-pre s e nt
Dr Iz od w as a Royal Socie ty Re s e arch
Fe low and is curre ntly Re ade r in Main
Group Ch e m is try.
te l: 44(0)19 1 222 7101
e m ail: k .j.iz od@ ncl.ac.uk
Re s e arch inte re s ts : Main group ch e m is try
Lanth anide Ch e m is try
Our inte re s t lie s in tw o are as (i) th e
ch e m is try of low oxidation s tate
lanth anide com ple xe s (including
“nonclas s ical” s ys te m s containing
Tm (II) or Nd(II)) w ith s oft C-or Pdonor
ligands , and (ii) lanth anide (III)
alk yl and h ydride com ple xe s
s upporte d by s oft donor ligand
s caffolds as catalys ts for ole fin
trans form ation s uch as
polym e ris ation, h ydros ilylation and
h ydroam ination.
H e te roatom -Stabilis e d Carbanions
Carbanions s tabilis e d by h e te roatom s
s uch as P or Si play a m ajor role in
conte m porary organic s ynth e s is . W e
are inte re s te d in (i) s tructure -
re activity re lations h ips , (ii) th e
influe nce of pe riph e ral
functionalis ation on ligand binding
pre fe re nce s , and (iii) th e s tabilis ation
of carbanions by h e avie r h e te roatom s
s uch as As and Bi.
Main Group Organom e ta lics
W e are inte re s te d in th e s tabilis ation
of unus ual organom e ta lic de rivative s
of th e m ain group e le m e nts ,
e s pe cia ly of th e h e avie r e le m e nts
from groups 1 and 2 and group 14.
[3] Synth e s is and s tructure s of Ln(II) and Ln(III)
dialk yls de rive d from LnI 2 (Ln = Nd, Tm , Yb).
L. J. Bow m an, K. Iz od, W . Cle gg, R. W .
H arrington, Organom e ta lics , 2007, 26, 2646.
[4] Agos tic-type B-H … Pb inte ractions s tabiliz e
a dialk ylplum byle ne . Structure of and bonding
in [{nPr 2 P(BH 3 )}(Me 3 Si)C(CH 2 )] 2 Pb. K. Iz od,
W . McFarlane , C. W i ls , W . Cle gg, R. W .
H arrington, Organom e ta lics 2008, 27, 4386.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Dr Julian Knigh t
BSc, Unive rs ity of Cam bridge , 19 85
Ph D Unive rs ity of Cam bridge , 19 89
Pos tdoctoral fe low , Im pe rial Co le ge
London, 19 89 -19 9 1
Ne w cas tle Unive rs ity 19 9 1-pre s e nt.
Dr Knigh t is s e nior le cture r in organic
ch e m is try.
te l: 44(0) 19 1 222 7068
e m ail: j.g.k nigh t@ ncl.ac.uk
Synth e s is
Us ing pa ladium catalys e d
carbonylations , de ve lope d w ith in th e
group, w e h ave com ple te d th e
s ynth e s is of th e natural product
de oxym annojirim ycin and are
e xte nding th is to m ore com ple x
alk aloid targe ts .
Ne w Ligands for Catalys is
Oxaz oline s . W e h ave de s igne d a
num be r of ne w ch iral oxaz oline
ligands for e nantios e le ctive
organocatalys is .
Ph os ph ine s . W e are inte re s te d in
de s igning s traigh tforw ard route s to
Se le cte d publications
Re s e arch inte re s ts : Organic s ynth e s is and catalys is
[1] Enantios e le ctive Synth e s is of 3,6-Dih ydro-
1H -pyridin-2-one s : Une xpe cte d
Re gios e le ctivity in th e Pa ladium Catalyz e d
De carboxylative Carbonylation of 5-
Vinyloxaz olidin-2-one s . J. Am . Ch e m . Soc.,
2000, 122, 29 44.
[2] Total Synth e s is of De oxym annojirim ycin and
D-Mannolactam via Carbonylation of 5-
Vinyloxaz olidin-2-one s . Te trah e dron, 2003, 59 ,
281.
ne w ph os ph ine ligands for catalys is .
Th e s e include : a z irconium -m e diate d
one -pot s ynth e s is of a ne w range of
1,4-diph os ph ine s (NUPH OS), and a
Die ls -Alde r bas e d s ynth e s is of bulk y
e le ctron rich biaryl-lik e
m onoph os ph ine s (KITPH OS).
Polym e rs & Ionic Liq uids
W e are inte re s te d in th e de s ign of
im m obilis e d ligands s uch as
ph os ph ine s and oxaz oline s . W e are
inve s tigating covale nt im m obilis ation
into polym e ric fram e w ork s and
'ph as e -tagging' in s pe cific ionic
liq uids .
[3] Synth e s is of a Ne w Clas s of 1,4-
Bis (diph e nylph os ph ino)-1,3-Butadie ne Bridge d
Diph os ph ine , NUPH OS, via Z irconium -
Me diate d Re ductive Coupling of Alk yne s and
Diyne s : Applications in Pa ladium -Catalyz e d
Cros s -Coupling Re actions . Organom e ta lics ,
2002, 21, 1383.
[4] Biaryl-Lik e CATPH OS Diph os ph ine s via
Double Die ls – Alde r Cycloaddition be tw e e n 1,4-
Bis (diph e nylph os ph inoyl)buta-1,3-diyne and
Anth race ne s ...Organom e ta lics , 2008, 27, 1679 .
h ttp://w w w .ncl.ac.uk /ch e m is try
22

23
As ym m e tric catalys is
Th e th e m e of our w ork is th e de s ign
of ch iral Le w is acids as catalys ts for
carbon-carbon bond form ing
re actions . Th us , w e h ave de ve lope d
s ale n com ple xe s of titanium and
vanadium as catalys ts for as ym m e tric
cyanoh ydrin s ynth e s is by th e addition
of a cyanide s ource to an alde h yde or
k e tone . Unlik e oth e r catalys ts for th is
re action, our com ple xe s are active at
room te m pe rature and at
s ubs trate :catalys t ratios of 1000:1. As
a re s ult, our w ork h as be e n lice ns e d,
s cale d-up and com m e rcializ e d by
NPil Ph arm ace uticals .
Se le cte d Publications
[1] Me ch anis m -guide d de ve lopm e nt of
VO(s ale n)X com ple xe s as catalys ts for th e
as ym m e tric s ynth e s is of cyanoh ydrin
trim e th yls ilyl e th e rs . Ch e m . Eur. J. 2009 , 15,
2148.
[2] Synth e s is of cyclic carbonate s from
atm os ph e ric pre s s ure carbon dioxide us ing
e xce ptiona ly active alum inium (s ale n)
com ple xe s as catalys ts . Eur. J. Inorg. Ch e m .
2007, 3323.
Profe s s or Mich ae l North
DPh il Unive rs ity of Oxford 19 88
Pos tdoctoral fe low , Nottingh am 19 89 -19 9 0
Unive rs ity of W ale s , Bangor 19 9 0-19 9 5
Kings Co le ge , London 19 9 5-2004
Ne w cas tle Unive rs ity 2004-pre s e nt
Profe s s or North is co-Dire ctor of th e
Re s e arch Ce ntre in Catalys is and Inte ns ifie d
Proce s s ing.
te l: 44(0)19 1 222 7128
e m ail: m ich ae l.north @ ncl.ac.uk
Re s e arch inte re s ts : Organic s ynth e s is , m e ch anis m s & catalys is
Catalys ts to conve rt w as te CO 2 into
us e ful ch e m icals
Tw o of th e m ajor ch a le nge s in th e
21s t ce ntury are : com bating clim ate
ch ange and finding re ne w able
s ource s for bas ic organic
com pounds . W e are w ork ing on th e
de ve lopm e nt of catalys ts w h ich w i l
conve rt w as te CO2 at atm os ph e ric
pre s s ure and am bie nt te m pe rature
into us e ful ch e m icals . W e h ave
re ce ntly pate nte d and publis h e d a
uniq ue clas s of bim e ta lic catalys ts
w h ich w i l conve rt w as te CO2 into
cyclic carbonate s .
[3] Me ch anis m of cyclic carbonate s ynth e s is
from e poxide s and CO 2 , Ange w . Ch e m . Int.
Ed. 2009 , 48, 29 46.
[4] One -com pone nt catalys ts for cyclic
carbonate s ynth e s is , Ch e m . Com m un. 2009 ,
2577-2579 .
[5] In s itu form ation of h e te robim e ta lic s ale n
com ple xe s containing titanium and/or
vanadium ions . Inorg. Ch e m . 2008, 47, 3801.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try 24
Dr Andre w Pik e
BSc, Ne w cas tle Unive rs ity, 19 9 4
MSc H ok k aido Unive rs ity, Japan 19 9 8
Ph D Ne w cas tle Unive rs ity, 2001
INEX 2004-2005
Ne w cas tle Unive rs ity 2005-pre s e nt.
Dr Pik e is an RCUK acade m ic fe low in
nanos cie nce .
te l: 44(0) 19 1 222 7061
e m ail: a.r.pik e @ ncl.ac.uk
Re s e arch inte re s ts : Nanom ate rials and s ynth e tic biology
Nanos cale m ate rials
I am inte re s te d in th e DNA-dire cte d
as s e m bly of conductive m ate rials for
e le ctronic applications and in
particular 1D nanow ire s . DNA can be
m odifie d in s e ve ral w ays including (i)
covale nt attach m e nt of groups to th e
nucle obas e s th rough s ynth e tic
organic ch e m is try, (ii) as s ociation of a
cationic group to th e double h e lix
th rough e le ctros tatic inte ractions w ith
th e ph os ph ate back bone , and (iii) th e
non-covale nt inte gration of
inte rcalating and groove -binding
m ole cule s . W e aim to e xploit th e s e
th re e m ode s of DNA m odification to
Se le cte d publications
[1] Tow ards DNA bas e d m ole cular e le ctronics
on s ilicon, A. R. Pik e , B. R. H orrock s , B. A.
Conno ly, A. H oulton, Aus . J. Ch e m ., 2002, 55,
19 1.
[2] DNA on s ilicon de vice s : On-ch ip s ynth e s is ,
h ybridiz ation, and ch arge trans fe r, A. R. Pik e ,
L. H . Lie , R. A. Eagling, L. C. Ryde r, S. N.
Patole , B. A. Conno ly, B. R. H orrock s , A.
H oulton Ange w . Ch e m . Int. Ed., 2002, 41, 615.
as s e m ble conductive polym e rs , m e tal
nanoparticle s and re dox groups into
nove l nanos cale m ate rials .
Synth e tic biology
One de finition is "th e re -de s ign of
natural biological s ys te m s for anoth e r
us e ful purpos e ". 2D-ne tw ork s and 3Ds
tructure s can be cons tructe d us ing
com ple m e ntary s e q ue nce s of DNA.
W e are de ve loping e nz ym atic
m e th ods th at can be us e d not only to
fabricate DNA-bas e d s ys te m s , but
w i l als o a low for th e de s ign of nove l
functionalitie s th at are not natura ly
as s ociate d w ith DNA.
[3] Covale nt and non-covale nt attach m e nt and
patte rning of polypyrrole at s ilicon s urface s , A.
R. Pik e , S. N. Patole , N. C. Murray, T. Ilyas , B.
A. Conno ly, B. R.H orrock s , A.H oulton, Adv.
Mat., 2003, 15, 254.
[4] Fe rroce nyl-Modifie d DNA: Synth e s is ,
Ch aracte riz ation and Inte gration w ith
Se m iconductor Ele ctrode s , A. R. Pik e , L. C.
Ryde r, B. R. H orrock s , W . Cle gg, B. A.
Conno ly, A. H oulton, Ch e m . Eur. J. 2004, 11,
344.
h ttp://w w w .ncl.ac.uk /ch e m is try

25
DNA Re cognition
Targe ting s pe cific s e q ue nce s or
s tructure s in nucle ic acids is a
prom is ing s trate gy for th e
de ve lopm e nt of drugs to de te ct and
de fe at dis e as e at th e m os t
fundam e ntal le ve l.
Se le cte d Publications
[1] Dis pe rs ions Of Alk yl-Cappe d Silicon
Nanocrys tals In Aq ue ous Me dia:
Ph otolum ine s ce nce And Age ing. Analys t,
2008, 133, 1573.
[2] Me ch anical and Ele ctroconductive
Prope rtie s of Spatia ly Dis tribute d Double -
Strande d DNA Arrays on Au(111). Th in Solid
Film s , 2008, 516, 89 69 .
Dr Eim e r Tuite
BSc Trinity Co le ge , Dublin 19 89
Ph D Trinity Co le ge , Dublin 19 9 2
Pos tdoctoral fe low , As s ociate Profe s s or
Ch alm e rs Te k nis k a H ögs k ola (CTH ) in
Göte borg, Sw e de n 19 9 2-2000
Ne w cas tle Unive rs ity 2000-pre s e nt
Dr Tuite is a m e m be r of th e Ch e m ical
Nanos cie nce Laboratory.
te l: 44(0)19 1 222 5523
e m ail: e .m .tuite @ ncl.ac.uk
Re s e arch inte re s ts : Bioph ys ical ch e m is try & nanos cie nce
Oxidative DNA Dam age
Our s tudie s look at th e m e ch anis m s
of oxidative dam age and h ow to
pre ve nt it, and contro le d induction of
DNA dam age for various applications
(e .g. de s troying bacte ria and virus e s ).
Mole cular Ele ctronics
Bioanalytical Ch e m is try
W e are particularly inte re s te d in
W e s tudy h ow dye s , q uantum dots , ch arge trans fe r and m igration in DNA-
and m e tal nanoparticle s can be us e d bas e d as s e m blie s . Th e s e are s tudie d
to analys e biom ole cule s and at th e s ingle m ole cule le ve l us ing
biom ark e rs , us ing fluore s ce nce and STM and AFM, and in bulk us ing
Ram an s pe ctros copy and m icros copy. ph otoph ys ical m e th ods .
[3] Spatial and Me ch anical Prope rtie s of Dilute
DNA Monolaye rs on Gold Im age d by AFM. J.
Ph ys . Ch e m . B, 2003, 107, 359 1.
[4] Ph otoble ach ing of As ym m e tric Cyanine s
Us e d for Fluore s ce nce Im aging of Single DNA
Mole cule s . J. Am . Ch e m . Soc., 2001, 123,
79 85.
[5] Picos e cond Tim e -Re s olve d Re s onance
Ram an Probing of th e Ligh t Sw itch State s of
[Ru(ph e n) 2 dppz ] 2+ . J. Ph ys . Ch e m . B, 2001,
105, 12653.
h ttp://w w w .ncl.ac.uk /ch e m is try
Sch ool of Ch e m is try

Sch ool of Ch e m is try
Be ds on Building
Ne w cas tle Unive rs ity
Ne w cas tle upon Tyne
NE1 7RU
UK
te l: 44 (0)19 1 222 7102
fax: 44 (0)19 1 222 69 29
pg.ch e m is try@ ncl.ac.uk
Application form :
h ttp://w w w .ncl.ac.uk /pos tgraduate /apply/applicationform s /
h ttp://w w w .ncl.ac.uk /ch e m is try