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Kompendium 2020 Forschung & Klinik

Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen. Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien Prof. Dr. R. Windhager ISBN 978-3-200-07715-7

Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen.

Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie
MedUni Wien und AKH Wien
Prof. Dr. R. Windhager

ISBN 978-3-200-07715-7

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Kompendium 2020

Forschung & Klinik

Universitätsklinik für

Orthopädie und Unfallchirurgie

MedUni Wien und AKH Wien

ISBN 978-3-200-07715-7

www.meduniwien.ac.at/ortho-unfall


.O.R.E.

I N S T I T U T E


Inhalt/Impressum

3

Die Klinik

4 Editorial

6 Klinische Leistungen und Operationen

9 Hohe Ambulanzfrequenz durch Spezialangebote

10 Interview mit o. Univ.-Prof. Dr. Reinhard Windhager:

„Seltene Erkrankungen und komplizierteste Behandlungen

sind unser Standard“

14 Die Expertinnen und Experten auf einen Blick

20 Ambulanzverzeichnis der Universitätsklinik

für Orthopädie und Unfallchirurgie

Impressum:

Herausgeber:

Universitätsklinik für

Orthopädie und

Unfallchirurgie MedUni Wien

und AKH Wien

o. Univ.-Prof. Dr. Reinhard

Windhager

Währinger Gürtel 18–20

1090 Wien

Redaktion & Gestaltung:

Unlimited Media

www.unlimitedmedia.at

Lektorat: Sophie Hermann,

BSc, Alexandra Lechner

Fotos: iStock-120190423,

Unlimited Media, MedUni

Wien/Christian Houdek,

Mark Glassner

Druckerei: Copydruck KG

Sandleitengasse 9–13

1160 Wien

Wien, Juli 2021

ISBN 978-3-200-07715-7

TOP-Studien

22 Quantitative Biochemical MRI of Hyaline Cartilage

26 Analysis of Running-Related Injuries: The Vienna Study

30 Rheumatoid Arthritis Disease Activity and the Risk

of Aseptic Arthroplasty Loosening

34 OSTEOGROW: Acceleration of Bone Healing

37 A Prediction Model for Total Knee Arthroplasty

40 tPA Serum Antigen Levels Predict ARDS

in Polytraumatized Patients

43 3D Biochips for Research on Inflammatory

Musculoskeletal Diseases

46 Biological Regeneration in Early Osteoarthritis

49 Total Hip Arthroplasties after Chiari Pelvic Osteotomy

52 The MOCART 2.0 Knee Score: Morphological MRI

for the Assessment of Cartilage Repair

55 The Genetic Landscape of Axonal Neuropathies:

Focus on MME

58 Distal Femur Replacement – Differences between

Oncologic and Non-Oncologic Conditions

62 Biomechanical Evaluation of Intramedullary

Jones Fracture Fixation

65 Development of a New Electronic Navigation System

Publikationen

68 Originalarbeiten 2020

E-Book

www.meduniwien.ac.at/orthopaedie

www.unlimitedmedia.at/orthopaedie2020


Editorial

4

Liebe Leserinnen und Leser!

Es freut mich, Ihnen zum vierten Mal das Kompendium der gemeinsamen

Klinik für Orthopädie und Unfallchirurgie, drei Jahre nach der Gründung dieser

Klinik und nach einem bemerkenswerten Jahr, präsentieren zu können.

o. Univ.-Prof. Dr. Reinhard Windhager

Viel wurde in den letzten Monaten über die Auswirkungen der Pandemie

reflektiert und publiziert, und es braucht nicht weiter ausgeführt zu werden,

wie sehr sich diese weltweite Katastrophe auf unsere Leistungszahlen im

klinischen Alltag niedergeschlagen hat. Trotz all dieser Belastungen ist es

gelungen, spitzenmedizinische Leistungen weiter und in unveränderter

Frequenz durchzuführen. Es sei allen Entscheidungsträgern gedankt, dass

dies in einem tertiären Versorgungszentrum möglich gemacht wurde. Auch

andere Aspekte dieser durch die Pandemie belasteten Zeit sollten nicht

unerwähnt bleiben, wie die Intensivierung der Digitalisierung, die sich positiv

im klinischen Alltag, aber vor allem im Bereich der wissenschaftlichen

Kommunikation ausgewirkt hat.

War es anfangs schwer vorstellbar, dass Workshops, Seminare, Symposien

und auch größere Kongresse digital abgehalten werden, so ist dies mittlerweile

zum Alltag geworden und wird in gewissem Ausmaß auch in Zukunft

nicht mehr wegzudenken sein. Diese gewonnene Zeit hat sich auch in der

regen Publikationstätigkeit niedergeschlagen und dazu beigetragen, dass

zahlreiche neue Projekte initiiert werden konnten. Die folgenden Seiten

sollen Ihnen einen kurzen Einblick in die Spitzenleistungen der Forschungsaktivitäten

unserer Klinik, die wie viele andere in Top-Journalen publiziert

werden konnten, geben.

An dieser Stelle sei auch allen Mitarbeiterinnen und Mitarbeitern für ihren

unermüdlichen Einsatz in diesen schwierigen Zeiten gedankt und dafür, dass

diese belastende Zeit positiv genutzt werden konnte.

Ich wünsche Ihnen viel Vergnügen beim Studium dieser Lektüre und würde

mich freuen, durch den einen oder anderen für Sie bemerkenswerten Aspekt,

Interesse an einer zukünftigen Kooperation zu wecken.

Ihr Reinhard Windhager


Zahlen und Fakten

6

Klinische Leistungen

und Operationen

Die Universitätsklinik für Orthopädie und Unfallchirurgie ist

eine Großklinik mit einem umfassenden Leistungsspektrum.

Trotz der umfangreichen Einschränkungen durch die Corona-Pandemie

wurden im Jahr 2020 an der Universitätsklinik für Orthopädie und Unfallchirurgie

insgesamt 6.530 Operationen durchgeführt. Im Jahr davor waren

es 7.039 – allerdings ohne Corona-Einschränkungen.

2.449 Operationen fielen in den Bereich der Orthopädie. Wobei hier betont

werden muss, dass es sich zumeist um hochspezifische Eingriffe handelte, die

an anderen Spitälern in Österreich gar nicht durchgeführt werden können. Es

wurden 315 Hüftendoprothesen, 277 Knieendoprothesen und 149 Fusionen der

Wirbelsäule durchgeführt. Hinzu kamen 341 Arthroskopien, 78 Fußoperationen,

286 Tumorresektionen und 83 Osteosynthesen. An der Klinischen Abteilung für

Unfallchirurgie wurden 3.265 Operationen durchgeführt.

Klinische Leistung Orthopädie 2019 2020

Operationen gesamt 2.945 2.449

unter anderem:

Fusionen der Wirbelsäule 173 149

Endoprothetische Versorgungen (gesamt) 731 653

davon Hüftendoprothesen 349 315

davon Knieendoprothesen 343 277

Arthroskopien (alle Gelenke) 435 341

Fußoperationen 132 78

Tumorresektionen 372 286

Osteosynthesen 94 83

Klinische Leistung Unfallchirurgie

Stationäre Aufnahmen 6.729 6.054

Anzahl Operationen 4.094 3.265

unter anderem:

Endoprothetische Versorgungen (gesamt) 249 192

Schädel-Hirn-Trauma 39 57

Wirbelsäulen-OP 72 70

Becken-/Acetabulum-Frakturen 13 32

Knie-Binnenverletzungen 474 334

Rekonstruktive Operationen an der Schulter 78 83

Handverletzungen 409 329

Thorax-/Abdomenverletzungen 34 24

periprothetische Frakturen 43 46

Osteosynthesen 763 606


Die bewährte

Hüfte

Qualität,

die bewegt.

www.implan-tec.at


Zahlen und Fakten

9

Hohe Ambulanzfrequenz

durch Spezialangebote

Die Universitätsklinik für Orthopädie und Unfallchirurgie versteht

sich als universitäres Zentrum zur Diagnose, Therapie

und Prävention von angeborenen und erworbenen Erkrankungen

des Bewegungsapparates. Durch den hohen Grad an Spezialisierung

und das große Angebot an Spezialambulanzen sind

die Ambulanzen einer sehr starken Frequenz ausgesetzt. Die

im Vergleich zu 2019 niedrigen Zahlen sind der Corona-Pandemie

geschuldet – wobei bei den Versorgungen im Gipszimmer

sogar eine massive Steigerung im Vergleich zu den Vorjahren

bemerkbar war.

In der Klinischen Abteilung für Orthopädie werden 21 höchst spezialisierte

Ambulanzen auf internationalem Niveau angeboten. Insgesamt kam es im

Jahr 2020 zu 23.306 Ambulanzbesuchen. Die höchsten Frequenzen wiesen

folgende Ambulanzen auf: Schmerztherapie (2.343), Tumororthopädie

(2.872), Rheumaorthopädie (2.486), Kinderorthopädie (1.805), Wirbelsäule

(1.550), Sportorthopädie (1.512), Endoprothetik (1.133), Sarkome (852) und

die Fußambulanz (403).

2019 2020

Ambulante Frequenzen Orthopädie (gesamt) 31.800 23.306

Schmerztherapie 5.097 2.343

Tumororthopädie 3.738 2.872

Rheumaorthopädie 3.019 2.468

Kinderorthopädie 2.145 1.805

Wirbelsäule 1.718 1.550

Sportorthopädie 1.712 1.512

Endoprothetik 1.320 1.133

Knochen- und Weichteilsarkome 951 852

Fußambulanz 694 403

Ambulante Frequenzen Unfallchirurgie

Ambulante Frequenzen (ABF) Erstversorgung 71.216 49.342

Ambulante Kontrollen (ABK) Nachbehandlung 51.452 34.704

SchockraumpatientInnen 566 507

Eingriffe in der Wundversorgung 4.675 3.616

Versorgungen im Gipszimmer 15.273 19.579


Klinik

10

Seltene Erkrankungen und

komplizierteste Behandlungen

sind unser Standard

Die Universitätsklinik für Orthopädie und Unfallchirurgie ist eine

der größten im AKH Wien und der MedUni Wien und genießt

vor allem im Bereich der hochspezialisierten Operationen

internationalen Ruhm. Die Corona-Pandemie hat aber, bei der

Behandlung der Patientinnen und Patienten, den über die letzten

Jahre steigenden Operationsfallzahlen und auch im Bereich der

Forschung massive Probleme bereitet und Rückgänge bewirkt.

o. Univ.-Prof. Dr. Reinhard Windhager

Welche Herausforderungen bewirkte die Corona-Krise im Jahr 2020 in

Bezug auf die Behandlung der Patientinnen und Patienten?

Das im Rahmen der Corona-Krise notwendige Schließen und konsekutive

Öffnen von Spitalsressourcen ging mit einem enormen organisatorischen

Aufwand einher, insofern als die Patientinnen und Patienten nicht auf einen

bestimmten Termin verschoben werden konnten, sondern in permanenter

Warteposition verharren mussten. Die sich ständig ändernde Verfügbarkeit

von Ressourcen war mit einer massiven organisatorischen Belastung des

gesamten ärztlichen und pflegerischen Personals verbunden.

Welche Teile der Patientenversorgung kamen zu kurz? Was wurde an

wichtigen Operationen verschoben, was wieder aufgeholt?

Grundsätzlich kann festgehalten werden, dass medizinische Versäumnisse

in keiner Weise zu verzeichnen waren, insofern als eine klare Priorisierung

von medizinisch dringlich notwendigen Eingriffen erfolgte. So wurden auch

während der Zeit des harten Lockdowns alle Tumoroperationen ebenso wie

septische Eingriffe entsprechend der Notwendigkeit durchgeführt. Unter

Berücksichtigung der Dringlichkeitsabstufung wurden Patientinnen und

Patienten mit chronischen Erkrankungen ohne dringenden medizinischen

Handlungsbedarf aufgeschoben und nach Ende des Lockdowns, spätestens

mit 1. Juni 2020, als alle Ressourcen wieder zu 100 Prozent zur Verfügung

standen, bis zum Herbst operativ versorgt. Erfreulicherweise haben viele

nicht dringliche Patientinnen und Patienten aufgrund der allgemeinen

Verunsicherung und der Schwierigkeiten in der Nachbehandlung ihre

Operationstermine bereits auf einen späteren Zeitpunkt verschoben.

Welche Leistungen/Operationen bietet nur die Universitätsklinik für

Orthopädie und Unfallchirurgie an, die sonst kaum oder gar nicht in

Österreich gemacht werden können?


Klinik

11

Neben der Polytrauma-Versorgung im unfallchirurgischen Bereich, die auf

wenige Trauma-Zentren konzentriert ist, sind es vor allem komplexe Tumoroperationen

und rekonstruktive Eingriffe im Bereich der Extremitäten und

der Wirbelsäule. Hierunter fallen komplexe Gliedmaßenfehlbildungen wie

Skolioseoperationen und En-bloc-Resektionen an der Wirbelsäule bei primär

malignen Knochentumoren. Als tertiäres Versorgungszentrum sind wir auch

die einzige Anlaufstelle für alle multimorbiden Patientinnen und Patienten,

die sonst nirgendwo zur Operation aufgenommen werden.

„Auch während der Zeit des harten

Lockdowns in der Corona-Krise wurden

alle Tumoroperationen ebenso

wie septische Eingriffe entsprechend

der Notwendigkeit durchgeführt.“

Reinhard Windhager

Hat sich die Krise auch auf die Forschungstätigkeit ausgewirkt?

Die Zeit des Lockdowns hat sicherlich mehr Möglichkeiten geboten, Studien

die bereits durchgeführt oder in Ausarbeitung waren, fertigzustellen und

abzuschließen. Andererseits konnten interessante Konzepte für weitere Studien

in dieser Zeit geboren werden. Dank dem Einsatz aller Mitarbeiterinnen

und Mitarbeiter wurden prospektiv randomisierte Studien nur geringgradig

in Bezug auf Rekrutierung während des Lockdowns beeinträchtigt, jedoch

insgesamt nicht unterbrochen.

Welche herausragenden Forschungsgebiete sehen Sie – in der Gegenwart,

aber auch in der Zukunft?

Entsprechend dem allgemeinen Trend der Personalisierung konzentrieren

wir uns seit längerer Zeit nicht nur auf die Individualisierung von Behandlungskonzepten,

sondern auch auf die differenzierte Planung und Durchführung

von Operationen im Rahmen des institutionsübergreifenden Projektes

des 3D-Druckverfahrens, das sowohl für Kunststoff als auch Metalle an der

Universität umgesetzt werden kann. Weiter ausgebaut werden auch die Analyse

von Biomarkern als Prognosefaktoren im Polytrauma-Management, die

Anbindung verschiedenster differenzierter bildgebender Verfahren inklusive

der biochemischen Bildgebung und das zukunftsträchtige Forschungsgebiet

der Biochip-Technologie, mit der organtypische, gewebsähnliche Mikrosysteme

als dreidimensionales Krankheitsmodell des Gelenkes dargestellt

werden können und die degradative sowie inflammatorische Prozesse

simulieren lässt.

Wie liegt die MedUni bei der Forschung im internationalen Vergleich?

Der wissenschaftliche Output der MedUni Wien kann der Homepage

entnommen werden und ist mehr als beeindruckend. Auch in unserem

Bereich ist eine kontinuierliche Zunahme des wissenschaftlichen Out -

puts über die letzten Jahre und entsprechend der Zunahme der Impact-

Faktoren auch ein kontinuierlicher Anstieg der Qualität der publizierten

Forschungsergebnisse zu verzeichnen. Direkte Vergleiche mit anderen

Institutionen sind nur schwer möglich, da die Ergebnisse öffentlich nur

als Gesamtergebnis wiedergegeben werden und somit ein direktes

Benchmarking verunmöglichen.

Welche Kooperationen gibt es mit Firmen bzw. anderen Kliniken?

Die Interaktion mit verschiedenen Kliniken ist durch die zahlreichen

klinischen Boards bestens etabliert und im Alltag vollkommen integriert.

Aus diesen klinischen Kooperationen, die alle wesentlichen Schwerpunkte

der Klinik betreffen, ergeben sich zahlreiche Fragestellungen und damit

Ansatzpunkte für neue Forschungsprojekte. Die Kooperationen mit den

Firmen sind jahrelang etabliert, wobei für neue, interessante Aspekte

weiterhin Platz sein wird.


Klinik

12

Wie wirkt sich die Forschung auf die Patientinnen und Patienten aus?

Entsprechend unserem Zugang als klinische Wissenschaftler ergeben sich

die Fragestellungen aus dem klinischen Alltag, sodass die Ergebnisse in

jedem Fall als klinisch relevant bezeichnet werden können und somit Auswirkungen

auf klinische Entscheidungsprozesse oder Behandlungsmodalitäten

von Patientinnen und Patienten haben.

Wie haben sich die Änderungen in der Ausbildung an der Klinik etabliert?

Durch die Umsetzung des neuen Ausbildungscurriculums ist eine intensivere

Verbindung der beiden klinischen Abteilungen für Orthopädie und

Unfallchirurgie eingetreten. Einzig und allein die hohe Vorhaltekapazität,

welche durch die für den Akutbereich notwendige personelle Vorhaltekapazität

der Unfallchirurgie bedingt ist, bewirkt ein Missverhältnis in der

Rotation, sodass vereinzelt Teile der orthopädischen Ausbildungszeit an

einer auswärtigen Institution verbracht werden müssen. Diesem Umstand

kann allerdings durch die Notwendigkeit eines Auslandsaufenthaltes,

der als Voraussetzung für eine klinische Karriere von der MedUni vorgeschrieben

ist, Rechnung getragen werden.

„Entsprechend dem allgemeinen Trend

der Personalisierung konzentrieren

wir uns seit längerer Zeit nicht nur auf

die Individualisierung von Behandlungskonzepten,

sondern auch auf die

differenzierte Planung und Durchführung

von Operationen im Rahmen des

institutionsübergreifenden Projektes

des 3D-Druckverfahrens, das sowohl

für Kunststoff als auch Metalle an der

Universität umgesetzt werden kann.“

Reinhard Windhager

Welche Ausbildungsinhalte sind für Sie wichtig?

Die an unserer Universitätsklinik in Ausbildung Stehenden haben die einzigartige

Möglichkeit, seltene Erkrankungen und komplizierteste Behandlungen

in hoher Frequenz zu sehen, wodurch das Spektrum der Ausbildung wesentlich

vergrößert wird.

Wie wichtig ist die Zertifizierung zum Endoprothetikzentrum mit

Maximalversorgung für die Klinik?

Die frühere Universitätsklinik und jetzige klinische Abteilung für Orthopädie

wurde als erstes Zentrum in Österreich zertifiziert und anerkannt.

Die dadurch eingetretene Steigerung der Behandlungsqualität sollte

eigentlich keiner Patientin, keinem Patienten vorenthalten werden, sodass

zu fordern ist, dass eine flächendeckende Zertifizierung forciert wird.

Patientinnen und Patienten haben das Recht, in transparenter Form über

Behandlungserfolge informiert zu werden und darauf pochen zu können,

dass das Minimum an Operationsfrequenz für die Durchführung des bevorstehenden

Eingriffs zur Verfügung steht. Dies betrifft in weiterer Folge

auch Revisionen, die ab einem gewissen Grad an ein Zentrum überwiesen

werden sollten, um der Patientin, dem Patienten die maximale Behandlungsoption

bieten zu können.

Welche Fortschritte hat die Endoprothetik in den letzten Jahren gemacht?

Neben einigen relevanten Neuerungen in der Implantologie, die sich auch

klinisch ausgewirkt haben, sind es vor allem die verbesserte Planung und

Planungsmöglichkeit der Endoprothetik mit entsprechender differenzierter

Umsetzung, aber auch neue Methoden, wie die 3D-Drucktechnologie,

die vor allem bei individuell angefertigten Prothesen im Beckenbereich Anwendung

findet und durch neue Modifikationen eine deutlich verbesserte

Osteointegration ermöglicht. Durch diese verschiedenen Differenzierungen

sind jedoch mehr Fragen als Lösungen aufgetaucht, die die Forschung

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Das ÄrztInnenteam

14

Die Expertinnen und

Experten auf einen Blick

Neben dem Fortschritt in der Medizintechnik und innovativen

Medikamenten sind vor allem die Mitarbeiterinnen und Mitarbeiter

ein essenzieller Garant für den optimalen medizinischen

Erfolg. Die rund 100 Ärztinnen und Ärzte der Universitätsklinik

für Orthopädie und Unfallchirurgie im AKH Wien profitieren

dabei auch vom exzellenten Netzwerk, dem wertschätzenden

Umgang miteinander und der zielorientierten, individuellen

Fort- und Weiterbildung.


Das ÄrztInnenteam

15

Universitätsklinik für Orthopädie und Unfallchirurgie

Leiter: o. Univ.-Prof. Dr. Reinhard Windhager

Klinische Abteilung für Orthopädie

o. Univ.-Prof. Dr. Reinhard Windhager

ao. Univ.-Prof. in Dr. in Catharina Chiari, MSc

Univ.-Prof. Dr. Alexander Giurea

Klinische Abteilung für Unfallchirurgie

Assoz. Prof. Priv.-Doz. Dr. Stefan Hajdu, MBA

Assoz. Prof. in Priv.-Doz. in Dr. in Silke Aldrian

Mitarbeiterinnen und Mitarbeiter:

(in alphabetischer Reihenfolge)

Dr. Lukas Albrecht

Dr. Jürgen Alphonsus

Dr. in Anna Antoni

Dr. Sebastian Apprich

Univ.- Prof. in Dr. in Michaela Auer-Grumbach

Mag. a Dr. in Rita Babeluk

Dr. Sebastian Bachl

Dr. Oskar Bamer

Dr. in Elena Batrina

DI Dr. Emir Benca

Mag. a Marilena Bertacco

Dr. Harald Binder

Priv.-Doz. DDr. Christoph Böhler

Dr. Robert Breuer (karenziert)

Dr. Alexander Bumberger

Dr. in Miroslava Cernakova

Dr. in Britta Chocholka (karenziert)

Dr. in Theresia Dangl

Dr. Michél Dedeyan (karenziert)

Dr. Stephan Döring

Dr. in Nevenka Drmic

Dr. Alexander Egkher

Dr. Lukas Eichelberger

Dr. Jozsef-Tibor Erdös

Dr. in Emilia Eredansky

Mag. a Seyma Ergün

Dr. Georg Fraberger

Dr. Stephan Frenzel

Ass.-Prof. Dr. Martin Frossard (Internist)

Assoz. Prof. Priv.-Doz. Dr. Philipp Funovics, MSc

Dr. Markus Gregori

Ass.-Prof. Dr. Manfred Greitbauer

Univ.-Prof. Dr. Josef Grohs

Dr. in Luiza Grünberg

Dr. Thomas Haider, PhD

Dr. Gabriel Halát

Dr. in Martina Hamböck

Dr. in Martina Hauser-Shinhan

ao. Univ.-Prof. Dr. Thomas Heinz

Dr. Stephan Heisinger

Priv.-Doz. Dr. Gerhard Hobusch, MSc

Assoz. Prof. Priv.-Doz. Dr. Marcus Hofbauer

Dr. Florian Hofmann

Dr. in Katharina Hohenstein-Scheibenecker

Dr. in Sabrina Holzer, BA (karenziert)

Dr. in Laura Hruby, PhD

Dr. Florian Hruska

Dr. Zhaohui Hu

Dr. Michael Humenberger

Dr. in Manuela Jaindl

Dr. in Nina Janjic

Dr. Nikolaus Jantsch

Dr. Fatmir Kabashi

Dr. Georg Kaiser

Priv.-Doz. Dr. Maximilian Kasparek, MSc

Univ.-Prof. Dr. Richard Kdolsky

Dr. in Anne Kleiner

Priv.-Doz. Dr. Alexander Kolb

Dr. Paul Kolbitsch

Dr. Ulrich Koller, MSc

Dr. in Irena Krusche-Mandl

Assoz. Prof. Priv.-Doz. Dr. Bernd Kubista, MSc

Dr. in Roberta Laggner

Dr. Nikolaus Lang, MSc

Priv.-Doz. Dr. Richard Lass, MSc

Assoz. Prof. Priv.-Doz. Dr. Johannes Leitgeb

Dr. in Monika Luxl

Ass.-Prof. Dr. Wolfgang Machold

Dr. Bernhard Maier

Dr. in Ulrike Marquart

Dr. Michael Matzner

Dr. Timon Moftakhar

Dr. in Claudia Müller

Priv.-Doz. Dr. Lukas Negrin, PhD, MSc

Dr. Georgios Neophytou

Dr. Arastoo Nia

Dr. in Sylvia Nürnberger

Dr. in Karin Pagano-Braun

Ass.-Prof. Dr. Gholam Pajenda

Assoz. Prof. Priv.-Doz. Dr. Joannis Panotopoulos

DDr. Stephan Payr

Dr. Stefan Plesser

Dr. in Sigrid Polzer

Dr. Domenik Popp

Priv.-Doz. Dr. Stephan Puchner

Dr. in Colleen Rentenberger

Dr. Gregor Rettl


Das ÄrztInnenteam

16

Weitere Teammitglieder

DI Dr. in Anna Rienmüller

Dr. Stephan Salzmann

Ass.-Prof. Dr. Klaus-Dieter Schatz

Dr. Philip Schefzig

Dr. Philipp Scheider

Dr. in Eleonora Schneider

Dr. Markus Schreiner

Dr. Rupert Schuster

Dr. Gilbert Schwarz

Ass.-Prof. in Dr. in Elisabeth Schwendenwein

Dr. Florian Sevelda, MSc

Dr. in Irene Sigmund

Ass.-Prof. Dr. Gobert Skrbensky

Dr. Bernhard Springer

Dr. Kevin Staats

Dr. in Julia Starlinger, PhD (karenziert)

Dr. in Beate Stelzeneder

Dr. in Sandra Stenicka (karenziert)

Priv.-Doz. Dr. Christoph Stihsen

Ass.-Prof. Dr. Walter Stoik

Dr. in Geraldine Sturz

Dr. in Gerhild Thalhammer

Dr. Thomas Tiefenböck, MSc

Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel

Dr. Klemens Vertesich

Dr. Rainer Wagner

Ap. Prof. Priv.-Doz. Dr. Wenzel Waldstein-Wartenberg

Dr. in Valerie Weihs

Priv.-Doz. Dr. Harald K.Widhalm

Dr. in Madeleine Willegger

ao. Univ.-Prof. Dr. Gerald E. Wozasek

Dr. Lukas Zak

Dr. in Cornelia Zeitler

Mag. a Dominika Zurawaska

GastärztInnen und Beobachter im Jahr 2020

Dr. Jamal Abdel-Karim Al-Omari,

Dr. Chang-Bae Kong


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Wiener Gesundheitsverbund

Teilunternehmung AKH Wien

Universitätsklinik für

Klinische Abteilung für Orthopädie

PatientInnenversorgung

Forschung

Spezialambulanzen

Schulter und Ellbogen

Sportchirurgie Knie

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Das ÄrztInnenteam

19

Medizinische Universität Wien

Orthopädie und Unfallchirurgie

Klinische Abteilung für Unfallchirurgie

Lehre

PatientInnenversorgung

Orthopädie

Studierendenausbildung

im Diplom- und

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Traumatische Knorpelschäden

Posttraumat. Deformitäten

und Gliedmaßenrekonstruktion

Kindertraumatologie

Sportambulanz

Handambulanz

Schulterambulanz

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Ambulanzen

20

Ambulanzverzeichnis der

Universitätsklinik für

Orthopädie und Unfallchirurgie

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Bettenhaus und werden als Bestellambulanz geführt (telefonische

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der Patientinnen und Patienten erfolgt durch die niedergelassenen

Fachärztinnen und -ärzte für Orthopädie. Die Spezialambulanzen

der Klinischen Abteilung für Unfall chirurgie und die Nachbehandlung

in der Unfallambulanz sind auf Ebene 6 angesiedelt

(telefonische Terminvereinbarung unter +43/1/404 00-59380).


Ambulanzen

21

Spezialambulanzen Klinische Abteilung für Orthopädie

Spezialambulanz für orthopädische Schmerztherapie

Endoprothesenzentrum der Maximalversorgung

• Spezialambulanz für Endoprothetik

• Spezialambulanz für Knie

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• Spezialambulanz für komplexe Revisionen und Extremitätenrekonstruktionen

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• Spezialambulanz für Knochen- und Weichteilsarkome

• Spezialambulanz für Rehabilitation und Prothetik

Wirbelsäulenorthopädie

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• Spezialambulanz für Skoliose und Wirbelsäulendeformitäten

Kinderorthopädie

• Spezialambulanz für Kinderorthopädie

• Spezialambulanz für Knorpelschäden

• Spezialambulanz für Klumpfuß

• Spezialambulanz für Extremitätendeformitäten

• Neuromuskuläre Fußambulanz

Rheumaorthopädie

• Spezialambulanz für Rheumaorthopädie

• Spezialambulanz für Fuß

• Spezialambulanz für Hand

Sportorthopädie

• Spezialambulanz für Sportorthopädie

• Spezialambulanz für Sportchirurgie Knie

• Spezialambulanz für Schulter und Ellbogen

Spezialambulanzen Klinische Abteilung für Unfallchirurgie

• Allgemeine Unfallambulanz – Erstversorgung

• Allgemeine Unfallambulanz – Nachbehandlung

• Ambulanz für Kindertraumatologie

• Ambulanz für Handchirurgie

• Ambulanz für Hüftverletzungen und posttraumatische Hüftbeschwerden

• Schulterambulanz

• Ambulanz für traumatische Knorpelschäden

• Ambulanz für posttraumatische Deformitäten und Gliedmaßenrekonstruktion

• Ambulanz für Sportverletzungen

• Ambulanz für posttraumatische Wirbelsäulenbeschwerden


TOP-Studien

22

Quantitative Biochemical MRI

of Hyaline Cartilage

„Our study demonstrated that T2

mapping enables the quantification

of patellar cartilage defect progression

in untreated defects over time,

[indicating its potential as a]

predictive marker of patellar

cartilage degeneration.“

Sebastian Apprich

The department of Orthopedic and Trauma Surgery at the Medical

University of Vienna has conducted a successful interdisciplinary

collaboration with the onsite High Field MR Centre of Excellence

of Prof. Trattnig for years. A major goal is the implementation and

improvement of new imaging techniques to explore the natural

course of cartilage defects and its potential repair techniques.

As a result of this collaboration the article „Potential predictive value of

axial T2 mapping at 3 Tesla MRI in patients with untreated patellar cartilage

defects over a mean follow-up of four years“ was published in the Journal of

Osteoarthritis and Cartilage in 2020. Magnetic resonance imaging (MRI), with

its high spatial resolution and its capability for superior soft tissue contrast,

represents the gold standard for diagnosis of incipient osteoarthritis, the

follow up of its natural course, and the treatment options.

High resolution MRI and newly developed semi-quantitative scoring systems

allow for the morphological assessment of the whole joint in patients

with Osteoarthritis (OA) (e.g. MOAKS (MRI Osteoarthritis Knee Score) and

in patients after surgical cartilage repair (Whole joint MRI assessment of

surgical cartilage repair of the knee: cartilage repair osteoarthritis knee

score (CROAKS)). Additionally, new imaging techniques (T2/T2* Mapping,

dGEMRIC, Sodium Imaging, gagCEST Imaging, …) have evolved over the

recent year, which enable a deeper sight into the compositional structure

of hyaline cartilage itself.

Study:

Apprich SR, Schreiner MM,

Szomolanyi P, Welsch GH, Koller

UK, Weber M, Windhager R,

Trattnig S. Potential predictive

value of axial T2 mapping at

3 Tesla MRI in patients with

untreated patellar cartilage

defects over a mean follow-up

of four years. Osteoarthritis

Cartilage. Osteoarthritis Cartilage.

2020 Feb;28(2):215–222

Advantages of T2 Mapping

T2 mapping has proven the capability to gain information about water

content and structure of the collagen fiber network of hyaline cartilage

by assessment of quantitative T2 relaxation times. For several reasons, T2

mapping provides some major advantages over other techniques. On one

hand it is relatively independent from the available field strength of the MRI

scanners and can be performed using a 1.5 Tesla scanner and upwards, on

the other hand it does not require the administrations of a contrast agent

and is feasible within a reasonable scan time.

Within the aforementioned publication, we demonstrated the potential of

axial T2 mapping for quantification of untreated early-stage patellar cartilage

lesions over time and assessed its capability as a potential predictive

marker for future progression. Our study cohort consisted of thirty patients

(mean age, 36.7 ± 11.1 years; 16 males), with early-stage patellar cartilage


TOP-Studien

23

defects (≤ International cartilage repair Society (ICRS) grade 2) at baseline

and no surgical or invasive treatment during the follow up (4.0 ± 1.6 years).

To ensure the technical consistency especially of the T2 mapping, hardware,

including the MR scanner and the knee coil, as well as the MR sequence

protocol, was identical for all subjects at both time points.

Following the ICRS grading system, morphological cartilage changes over

time were subdivided into a progression group, a non-progression group and

regression group. Quantitative analysis of cartilage defects was performed

by means of global and zonal T2 mapping (deep and superficial cartilage T2

values) at both time points.

Figure 1:

A 34-year-old female patient with an ICRS

grade 1 cartilage defect of the lateral facet on

high-resolution axial PD TSE morphological

image at baseline MRI. The corresponding axial

T2 map verifies a significant increase in global

cartilage T2 values. Furthermore, on the medial

apex of the T2 map, a punctual increase of T2

values can be seen at the superficial layer,

whereas the morphological image seems to

prove that the cartilage is intact (A). At follow

up after 3 ½ years (B), the morphological image

showed a progression of the cartilage defect,

not only for the lateral facet, but also for the

medial apex. The corresponding T2 map shows

a significant increase.


TOP-Studien

24

Figure 2:

A 42-year-old male patient with suspected

cartilage lesion at the apex of the patella on

high-resolution axial PD TSE morphological

image at baseline. The corresponding T2 map

shows a diffuse and slight increase of T2 values

in the same area (A). After 4 years (B), morphological

cartilage status seems to have improved,

together with a decrease of T2 values. The

bisected white frames symbolize typical ROI

placement for zonal assessment of deep and

superficial T2 values.

Results & Conclusions

As a result, we found significantly higher global T2 values at baseline in the

progression group (N = 11; 57.4 ± 7.8 ms), compared to patients without

progression of cartilage defect size (N = 17; 40.6 ± 6.9 ms). Furthermore, the

non-progression group showed only a minor increase in global T2 relaxation

times (43.1 ± 7.9 ms; P = 0.07) at follow up, whereas in the progression group

global (68,7 ± 19 ms; P = 0.02) and superficial T2 values (65,8 ± 8.2–79.8 ±

24.4 ms; P = 0.03) increased significantly. T2 values for healthy reference cartilage

remained stable (Figure 1). Surprisingly, in two patients an improvement

in ICRS grading was observed (regression group), with decreasing T2 values.

The ROC analysis showed an area under the curve of 0.92 (95%CI 0.82–1.0).

At a cut-off value of 47.15 ms, we found a sensitivity of 92% (false-positive

rate of 18%) for future progression of cartilage defects.

Dr. Sebastian Apprich

Author:

Since 2019 Sebastian Apprich

has been a consultant for

Orthopedic and Trauma Surgery

and coordinates the research

activities of the Magnetic

resonance Imaging Cluster.

His clinical interests focus on

joint preserving therapy as well

as hand and foot surgery. As a

result of his expanded research

activities, he has (co)authored

36 pubmed-listed articles and

holds an actual h-index of 17

points (scopus.com).

Taken together, our study demonstrated that T2 mapping enables quantification

of patellar cartilage defect progression in untreated defects

over time. Furthermore, elevated cartilage T2 values at baseline were

associated with longitudinal morphologic degeneration. Within this small

patient cohort with early-stage patellar cartilage defects, T2 mapping

seemed to be a potential predictive marker of patellar cartilage degeneration.

Therefore, this axial T2 mapping sequence, in combination with the

unique characteristics of the patella cartilage (thick cartilage, superficial

and parallel position to the body surface) might be well suited for future

prospective studies to evaluate the natural course of cartilage defects and

their treatment in vivo.

In the Future

Furthermore, our future research will focus to overcome current limitations

of 2-dimensional (2D) multi-echo-spin echo T2 mapping techniques in the

quantitative assessment of hyaline cartilage of the whole joint. Therefore,

further development of 3-D imaging techniques with possibility for multiplanar

reconstruction and, even more important, improvements of the timeconsuming

evaluation process of T2 maps by implementing automated segmentation

techniques in combination with Gray-Level Co-Occurrence Matrix

(GLCM) features will hopefully make quantitative T2 mapping more feasible

for clinical OA-research purposes.


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TOP-Studien

26

Analysis of Running-Related

Injuries: The Vienna Study

„Running-related injuries are multifactorial,

associated with personal data,

training load, anatomic malalignments,

and injury history. While it is impossible

to define a one-fits-all formula to reduce

the risk for RRI in general, runners with

a high risk of a specific injury could be

identified based on patient-specific training

profiles and running gaits, as well as

on pre-existing malalignments […], with

their diagnosis leading to an appropriate

and balanced training adaptation.“

Emir Benca

Most injuries related to running training manifest themselves

during the month of March. Knee injuries are particularly common,

and women seem to injure themselves more often than men. This

was the finding of a study conducted by the MedUni Vienna and

the Orthopädiezentrum Innere Stadt using data from Viennese

runners. The study has recently been published in the Journal of

Clinical Medicine.

According to current surveys, running is one of the favorite sport activities

across the globe. Fourteen percent of Austria’s population, age 15 and older,

are running at least once-, while another 17% are running less than once a

week, but still regularly. Despite the well-known health benefits of regular

running exercises, running is associated with running-related injuries (RRI)

with a yearly incidence of up to 79%. Studies suggest 7.7 running-related

injuries for recreational runners, and 17.8 for novice runners per 1,000 hours

of running, and the vast majority of them are related to overuse. The aims of

this study were the presentation of a heterogeneous running population with

running-related injuries, the analysis of a broad range of potential contributing

factors for most common RRIs and their combinations, and the investigation

if different running footwear categories affect injury incidences.

Study:

Benca E, Listabarth S, Flock

FKJ, Pablik E, Fischer C,

Walzer SM, Dorotka R, Windhager

R, Ziai P. Analysis of

Running-Related Injuries:

The Vienna Study. J Clin Med.

2020 Feb 6;9(2):438

Methods & Data

Using a thorough questionnaire in combination with malalignment and injury

data, a detailed description of a large population with running-related injuries

was presented. The running population is characterized by its heterogeneity, a

long running history, and a detailed description of the training data. The presentation

of the number of injured runners over the months shows a normal distribution

with a peak in March (Figure 1). An increase was observed during the

early winter months. This observation coincides with the onset of the „Vienna

City Marathon“, the largest national running event with over 40,000 participants,

which is held on the second weekend in April each year. While there

is no evidence that participating in long-distance races is associated with

overuse injuries, the presented data suggest that the accompanying increase

in training load must occur incrementally and include regeneration periods.

The observed injuries came exclusively from overuse. 178 patients suffered

from 244 injuries with 44 specific diagnoses, 45 were secondary injuries

to the one and same location. The injuries were mainly located at the knee

(41.2%), followed by the ankle joint (15.0%), and the foot (10.6%). Most

common were the patellofemoral pain syndrome (PFPS) (13.4%), the iliotibial


TOP-Studien

27

5

5

Patients (-)

10 15 20 25 30

Injury frequenca (-)

10 15 20

Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug Sep

PFPS

ITBFS Patellar tendinopathy Spinal injuries Ankle instability

Figure 1: Month of presentation.

Figure 2: Distribution of most common RRIs across sexes and age groups.

band friction syndrome (ITBFS) (12.3%), patellar tendinopathy (12.3%), spinal

injuries (11.2%), and instability of the ankle joint (8.4%) (Figure 2).

Results

The authors evaluated the association between the following factors: sex, age,

height, BMI, activity history, weekly activity hours, weekly mileage, weekly frequency,

as well as individual training habits (e.g. warming up, stretching) and

various anatomic malalignments with the five most common injury locations

including most common specific injuries in these sites. Knee injuries were positively

associated with lower BMI, and previous injury with similar complaints

as well as with malalignments (knee malalignment, especially varus knee,

and pes planus). The patellofemoral pain syndrome was positively associated

with lower training frequency, knee malalignment, and with lower height. The

iliotibial band friction syndrome showed a positive association with previous

injury and a negative association with BMI. Patients with patellar tendinopathy

had a lower BMI, showed a lower running pace, but more often knee and less

often hip malalignments than the others. Patients with injuries at the foot/

ankle reported less often a history of similar previous injuries and showed

a negative association with knee malalignment and pes planus, while ankle

instability was positively associated with weekly activity and pes cavus. Hip/

pelvis patients showed a positive association with running experience, scoliosis,

and patellar squinting, and a negative one with stretching after the run.

Lower back (spinal) injury patients showed a high proportion of scoliosis and

were positively related to higher BMI, but negatively to the varus knee. Injuries

to the lower leg were observed in patients with a higher running pace but had

a negative relationship with malalignment of the knee.

It is important to mention that single variables associated with a specific injury

or injury location must not be regarded as isolated contributing factors.

A RRI is the result of multiple associated factors in terms of anthropometrics

and malalignments in combination with previous injury history and exposure

to certain training load. None of the sustained RRI’s is associated with a

single variable only. An injury is sustained when the interaction of predisposing

factors, positive injury history, and a reached threshold in training load

becomes significant. Research questions should not focus on the effect of

single variables on a specific injury, but on specific injuries as a combination

of multiple variables as well as on the weighting of those variables in injury


TOP-Studien

28

prediction models. For example, our data showed BMI to be associated with

multiple injuries or injury sites, however, never as predominant regression

weight, when compared with other significant variables. On the other hand,

the odds to suffer PFPS, patellar tendinopathy or a knee injury in general, are

much higher in patients with knee malalignments. In other words, a present

knee malalignment will contribute more to the risk to suffer from a RRI than

BMI does, and therefore shows different clinical relevance. The patients

were not able to provide sufficient data to properly address the question if

different running footwear categories modify injury incidences. Interestingly,

a relatively low proportion of runners with the pes valgus deformity wear

motion-controlled traditional running shoes, even though they are recommended

specifically for them.

DI Dr. Emir Benca

Author:

Emir Benca holds a masters’

degree from TU Wien and a

PhD from Medical University of

Vienna. He is the head of the

Adolf Lorenz Lab for Biomechanics

and coordinates the

rapid prototyping cluster at

the Department of Orthopedics

and Trauma Surgery. He

is currently working at the AO

Research Institute Davos as a

visiting scientist. Dr. Benca has

participated in several half- and

full marathons, as well as the

Ironman 70.3 Austria in 2018.

Sex Discrepancy

A possible sex discrepancy (56% female, 44% male, ratio female: male: 1.25)

was observed in this study, indicating either a generally higher number of

female runners, women consulting a medical doctor sooner, or a higher injury

rate in women than men. While earlier studies showed lower ratios (0.76),

more recent literature shows a higher incidence in female injured runners

(1.16), suggesting that running nowadays is not predominantly a male sport.

Data from a nationwide survey have reported a ratio over the past five years

between female and male Austrians, who run at least once a week, to be

0.78 (range: 0.65 – 0.89). The „Vienna City Marathon” showed a finisher ratio

of 0.52 (range 0.48 – 0.55) for the half- and 0.24 (range 0.22 – 0.28) for the

full marathon (both increasing) over the same period. If the injury incidence

across sexes was equal, the anticipated result would be a higher incidence of

RRIs in men, especially across runners with higher total activity. Those runners

are more likely to participate in long-distance races. However, the sex ratio in

runners in the present study with five or more years of experience was 1.04. To

investigate if there was a difference in visit rates to doctors among sexes, the

patients were asked to indicate how often they visited a doctor per year. Women

reported 2.6 visits, which is 0.35 times more than men, which corresponds to

the well documented average yearly gynecologist visit rate of 0.41, which could

explain the higher rate in medical visits in women. In summary, the female to

male discrepancy seems to be based on a higher injury rate in women rather

than a higher number of female runners in general, a higher participation rates

in race events, or more frequent medical consultations in women.

Conclusion

In conclusion, running-related injuries are multifactorial, associated with

personal data, training load, anatomic malalignments, and injury history. While

it is impossible to define a one-fits-all formula to reduce the risk for RRI in

general, runners with a high risk of a specific injury could be identified based on

patient-specific training profiles and running gaits, as well as on pre-existing

malalignments, such as scoliosis, patellar squinting, knee malalignments,

and/or varus knee, with their diagnosis leading to an appropriate and balanced

training adaptation. Furthermore, awareness of injury risks and prevention

should be raised in running schools and by medical specialists.

In the end, running has remained a popular activity over decades, even though

it has been associated with a high incidence of overuse injuries. By presenting

the injuries the authors did not aim to discourage from running, but to provide

data for better understanding and to contribute to their prevention. We believe

running is still beneficial in many respects, enriching, and simply fun.


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TOP-Studien

30

Rheumatoid Arthritis Disease

Activity and the Risk of Aseptic

Arthroplasty Loosening

Rheumatoid arthritis (RA) is characterised by typical joint inflammation

and synovitis, which, if not treated effectively, leads to joint

destruction and functional disability. Although new treatment

strategies improved long-term outcomes tremendously, rates of

total hip and knee arthroplasty (THA/TKA) in patients with RA

remain considerable.

As RA differs fundamentally from osteoarthrosis (OA) in terms of prognosis,

pathogenesis, and medical treatment, outcomes of total joint arthroplasty

(TJA) and rates of complications would be expected to be different between

these two diseases. Aseptic loosening is the most common cause for surgical

revision after TJA with far-reaching implications, including an exchange of the

implant associated with decreased function, loss of bone stock and an increased

risk for further complications. Reasons for aseptic loosening are not

fully understood, but local inflammation is suspected to play a crucial role.

Systemic inflammation in RA might influence this process of local inflammatory-mediated

osteolysis and could lead to higher aseptic loosening rates

in RA patients, especially in those with increased inflammatory activity. The

objective of this study was to assess the influence of RA disease activity on

the risk of aseptic loosening after TJA. Furthermore, we evaluated if antirheumatic

therapy has an influence on the risk of aseptic loosening. Additionally,

we analysed the rates of radiographic aseptic loosening in OA patients, as a

control group without systemic inflammation.

Study:

Böhler C, Weimann P, Alasti F,

Smolen JS, Windhager R, Aletaha

D. Rheumatoid arthritis

disease activity and the risk of

aseptic arthroplasty loosening.

Semin Arthritis Rheum. 2020

Apr; 50(2):245–251

Patients and Methods

We ascertained data of 49 RA patients who underwent primary TJA with a

fully documented disease activity as well as a complete clinical and radiological

follow-up for analysis. Further we investigated a cohort of OA patient,

who were matched 2:1 for sex, age, date of surgery, and location of TJA as a

control group without systemic inflammation. We obtained demographic data,

comorbidities, antirheumatic therapy results, clinical and functional scores,

duration of surgery, and the type of implant. Due to the restricted number of

revision surgery because of aseptic loosening, we used radiological signs of

component loosening (RCL) as a more sensitive surrogate outcome parameter

for our main analysis. These included radiolucent lines (RLL) with a width

of ≥2mm, osteolysis exceeding 2mm in thickness, and implant migration of

≥2mm. Two independent observers, who were blinded for levels of disease ac-


TOP-Studien

31

Aseptic loosening is the most common

cause for surgical revision after TJA with

far-reaching implications.

„Inflammation in RA patients, as

evidenced by higher levels of disease

activity, increases the risk for radiographic

loosening after TJA. In OA

patients, as a control disease without

systemic inflammation, the risk is

significantly lower.“

Christoph Böhler

tivity and the clinical diagnosis (OA/RA), evaluated the radiographs. Patients

were seen after 6 weeks, 3 and 12 months, and then annually after the TJA.

The Simplified Disease Activity Index (SDAI) was used to determine disease

activity levels. At our rheumatology outpatient clinic, RA patients are followed

every 3 months, and their clinical and laboratory variables are documented

prospectively in an observational database. For statistical analysis we

performed Cox regression to estimate RCL based on SDAI, adjusting for the

anti-rheumatic therapy (conventional vs. biological disease modifying drugs,

DMARDs). Furthermore, we compared the rates of aseptic loosening and RCL

in RA and OA patients using the Chi-Square-Test, the Kaplan Meier method,

and applied the Log-Rank test to statistically compare survival distributions.

Results

32 patients (65.3%) underwent TKA, and 17 (34.7%) THA. All TKA were

cemented and all THA were fixated cementless. In total 18 (36.7%) showed

signs of RCL. Time integrated SDAI was significantly higher in patients with

RCL (median; 25th and 75th percentile: 10.8; 8.6 and 15.8) than in controls

without RCL (7.0; 2.7 and 15.5) (Figure 1; p=0.043).

When comparing RCL across patient groups in different RA disease activity states,

we found that in the remission group no patient showed signs of RCL (0/10),

whereas in the low and moderate/high disease activity groups 10/21 (47.6%)

and 8/17 (47.1%) patients, respectively, showed signs of RCL (p=0.023). RA

patients receiving biologicals had clearly lower rates of RCL (4/18; 22.2%) compared

to RA patients under traditional DMARD therapy (14/28; 50%). In logistic

regression analyses biologicals significantly reduced the risk of RCL with an

odds ratio (OR) of 0.192 (95% CI 0.042-0.891; p=0.035). The RCL rate was 36.7%

in the RA group and 13.6% in the OA group (p=0.002). This was mainly explained

by a higher rate of RCL in the TKA group (RA: 34.4%; OA: 6.5%; p=0.001), while

the rates in the THA group were only numerically higher in patients with RA

compared to OA (41.2% vs. 30.8%, respectively; p=0.528).

Discussion

The current study for the first time links the risk of aseptic loosening in RA

patients to the level of inflammation with higher disease activity being associated

with more frequent occurrence of radiographic loosening. Biological


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Figure 1: Time integrated SDAI was significantly

higher in patients with RCL (median; 25th and 75th

percentile: 10.8; 8.6 and 15.8) than in controls

without RCL (7.0; 2.7 and 15.5) (Figure 1; p=0.043).

DMARDs had a protective effect on such risk. This link between inflammation

and RCL was further substantiated in the comparison between RA and OA,

being particularly evident for TKA.

Priv.-Doz. DDr. Christoph Böhler

Author:

Christoph Böhler is a specialist

for Orthopaedics and Traumatology

at the Medical University of

Vienna. His clinical and scientific

focus are on primary and

revision arthroplasty. In August

2021 he will start a clinical

Adult Reconstruction Fellowship

at the University of Toronto,

Canada.

Local inflammation plays a pivotal role in the pathogenesis of aseptic loosening,

by which generation of wear debris between the bearing surfaces

leads to activation of macrophages and immune cells, which then release

pro-inflammatory cytokines like TNF-alpha and IL-6. These induce osteoclast

activation and lead to increased bone resorption, osteolysis and eventually to

aseptic loosening. The systemic inflammation of RA may play a role in enhancing

the local inflammation underlying the described processes leading to

aseptic loosening. The implication of these findings for clinical practice are

potentially substantial, at least for individuals with RA and TJA: no patients

in remission showed RCL. Analogously to the observation that in sustained

remission of RA joint damage does not progress, this makes the case that

in the presence of TJA even stricter disease control should be pursued, with

clinical remission being the clear treatment target. Biological DMARDs had

a protective effect on the risk of RCL. Previously, it has been shown that

TNF-inhibitors are able to stop the progression of joint destruction. The

majority of the patients in the biological DMARDs group were treated with

TNF-inhibitors, potentially also suggesting a role of TNF alpha in the mediation

of the inflammatory process leading to aseptic loosening.

Conclusion

Taken together, inflammation in RA patients, as evidenced by higher levels

of disease activity, increases the risk for radiographic loosening after TJA. In

OA patients, as a control disease without systemic inflammation, the risk is

significantly lower. Biological DMARDs may reduce the risk of RCL, although

this would need prospective evaluation. Our data suggest that RA patients

with TJA should regularly undergo orthopaedic and radiographic evaluation

and, in the context of treating RA to target, might be considered for a more

stringent control of disease activity.


Integriertes Patientenversorgungskonzept zur MACT-

Gelenksknorpelrekonstruktion

Exakte Indikationsstellung

Indikations- und Durchführungs empfehlungen

der Arbeits gemeinschaft „Geweberegeneration

und Gewebe ersatz“ zur Autologen

Chondrozyten-Transplanta tion (ACT). Behrens

P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier

C, Krackhardt T, Löhnert J, Marlovits S, Meenen NM,

Mollenhauer J, Nehrer S, Niethard FU, Nöth U, Perka C,

Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K

(2004). Z Orthop 142: 529-539

Hohe Zelldichte und hohe Zellvitalität

des Implantats

Effect of cell seeding concentration on the quality

of tissue engineered constructs loaded with adult

human articular chondrocytes. Concaro S, Nick lasson E,

Ellowsson L, Lindahl A, Brittberg M, Gatenholm P (2008).

J Tissue Eng Regen Med

Flexible Anpassung des Implantats bei

der Trans plantation und Wahrung einer

homogenen Zellmatrix

Stabilization of fibrin-chondrocyte constructs for

cartilage reconstruction. Meinhart J, Fussenegger M, Höbling W

(1999), Ann Plast Surg 42(6): 673-678

Knorpelbiobsat­Entnahme

Zellkultur züchten

MACT­Transplantation

Seit 2001 züchtet das Institut

für Gewebe- und Organrekonstruk

tion, kurz igo®,

autologe Zell kul turen für die

Knorpel zell rekon struk tion für mehr als 1.500 Patienten

erfolgreich an.

igo® ist ein privates biopharmazeutisches Unternehmen

und Pionier auf dem Gebiet der Zellkulturtechnik

und des Tissue Engineerings und aktiv

beteiligt an Entwicklung neuer Heilmethoden. Als

österreichisches Unternehmen glänzen wir mit

der besonderen räumlichen Nähe und dem direkten

Kontakt zu unseren Kunden.

Informieren Sie sich unter www.igor.at

Hohe Compliance des Patienten: Die für

die Nachtherapie verwendeten Geräte,

CPM Schiene sowie HPM Gerät verfügen

über eine Compliance­Überwachung. Wenn

der Patient hier compliant ist, kann man

davon ausgehen, dass er auch bei der

Physio therapie konsequent mitarbeitet, was

für den Erfolg der Therapie wesentlich ist.

Low frequency EMF regulates chondrocyte

differentiation and expression of matrix proteins.

Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002).

J Orthop Res, Vol. 20(1): 40-50

Postoperative Therapie

Die Kontrollierte Nachtherapie: wird

durch das Netz werk von geschulten Physiotherapeuten

unterstützt

MACT­Langzeittherapie

Autologous chondrocyte implantation postoperative

care and rehabilitation. Hambly K, Bobic V, Wondrasch B,

VanAssche D, Marlovits S (2006). Science and Practice.

Am J Sports Med 34(6): 1020-1038

A prospective, randomized comparison of traditional

and accelerated approaches to postoperative

rehabilitation following autologous chondrocyte

implantation: 2-year clinical outcomes. Jay R. Ebert,

William B. Robertson, David G. Lloyd, M.H. Zheng, David J. Wood,

Timothy Ackland (2010). Catilage 1(3)180-187

Wissenschaftliche Publikationen

mit igor Chondro­Systems

Clinical experience with matrix associated

autologous chondrocyte transplantation

(MACT). Ramadani F, Orthner E, Kitzler B,

Wallner B, Burghuber C, Fußenegger M, Meinhart J

(2005). Revista de ortopedie si traumatologie 1(6):

106-110

Transplantation of chondrocytes – longtime

experiments. Prof. Dr. Lars Peterson (2006)

Ergebnis nach ca. 18 Monaten

Quelle:

Klinik Diakonissen

Schladming

Seit 2006 läuft das Koopera ti onsprojekt Leomed/

Igor der integrierten Patientenver sorgung für

Knor pel rekon struktion.

Nach Implantation unterstützt Leomed die

Patienten bei der Organisation der Nachtherapie.

Informieren Sie sich unter www.leomed.at


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OSTEOGROW: Acceleration

of Bone Healing

Study:

Chiari C, Grgurevic L, Bordukalo-Niksic

T, Oppermann H,

Valentinitsch A, Nemecek E,

Staats K, Schreiner M, Trost C,

Kolb A, Kainberger F, Pehar S,

Milosevic M, Martinovic S, Peric

M, Sampath TK, Vukicevic S,

Windhager R. Recombinant

Human BMP6 Applied Within

Autologous Blood Coagulum

Accelerates Bone Healing:

Randomized Controlled Trial

in High Tibial Osteotomy

Patients. J Bone Miner Res.

2020 Oct;35(10):1893–1903.

The presented study was undertaken within the OSTEOGROW

collaborative project and has received funding from the European

Union’s Seventh Framework Programme for research, technological

development, and demonstration under grant agreement

No. 279239. The Department of Orthopedics at the Medical University

of Vienna (MUV) served as the study site for the clinical

study on a first in human application of recombinant BMP-6

(bone morphogenic protein – 6).

Prof. Reinhard Windhager (principal investigator) and Prof. Catharina Chiari

(sub-investigator) were the responsible scientists at the MUV. The international

consortium was coordinated by Prof. Slobodan Vukicevic (University of

Zagreb), who is a renowned expert in the field of BMP research.


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Figure 1: Bone mineral density (BMD) measurements.

BMD measured in the wedge of two

groups of high tibial osteotomy (HTO) patients

(autologous bone graft substitute [ABGS] and

placebo [PBO]) from baseline (measured before

the treatment) to weeks 9 and 14 after surgery.

BMD values in the reference cube at baseline

and weeks 9 and 14 after surgery.

„First in human application of rhBMP-6

in high tibial osteotomy for the acceleration

of bone healing.“

Catharina Chiari

The Study

Recombinant human bone morphogenetic proteins (rhBMPs) 2 and 7 have

been used in the treatment of long bone fractures in conjunction with

bovine collagen matrices. They showed side effects like redness and

swelling and induction of osteolysis in cancellous bone, i.e., metayphyis

of the tibia, radius, and hip 1 . Therefore, this project aimed to develop a

rh-BMP-based therapy with a carrier made from autologous blood. This

novel autologous bone graft substitute (ABGS) was composed of rhBMP6

applied within autologous blood coagulum (ABC) 2 . In the present study,

we assessed intraosseal administration of ABGS, i.e., rhBMP (rhBMP6)

loaded within autologous blood coagulum in adult patients who underwent

a high tibial osteotomy (HTO). This study was a randomized, double-blind,

and placebo-controlled phase I/II trial. The primary objective of the study

was to assess safety, tolerability, anti-BMP6 antibody response, if any, and

systemic pharmacokinetics (PK) of the application 100 μg rhBMP6/mL ABC

locally into the wedge gap after osteotomy. The secondary objective was to

assess the acceleration of bone healing in the wedge gap. The total number of

patients enrolled was 20 with a final assignment ABGS/PBO 1:1, 6 included

in phase I and 14 in phase II.


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Figure 2: X-ray images of isolated defect areas

from 2 patients treated with autologous bone

graft substitute (ABGS) or placebo (PBO) from day

1 to month 24. Black arrows shown for the defect

area at month 18 indicate more pronounced BMD

on X-rays of a PBO-treated patient compared with

ABGS. However, at 12 months, still there is a gap

in zone 4 (Z4) for both groups as shown on X-ray

images. At month 24, in the medial site of the gap

for both groups, an incomplete cortical-periosteal

surface restoration after plate removal is indicated

(yellow arrows).

Our Patients

Patients were followed for 0 to 24 months by clinical examination (safety),

computed tomography (CT), and serial radiographic analyses (efficacy) 3 .

The results showed no detectable anti-rhBMP6 antibodies in the blood of

any of the 20 patients at 14 weeks after implantation. During the following

24 months no serious adverse reactions were recorded. The CT scans from

defects of patients treated with rhBMP6/ABC showed an accelerated bone

healing compared with placebo at 9 weeks (47.8 ± 24.1 versus 22.2 ± 12.3

mg/cm 3 ; p = 0.008) and at 14 weeks (89.7 ± 29.1 versus 53.6 ± 21.9 mg/cm 3 ;

p = 0.006) follow-up (Figure 1). Radiographic analyses at weeks 6 and 24 and

months 12 and 24 suggested the advanced bone formation and remodeling

in rhBMP6/ABC-treated patients (Figure 2).

Conclusion

We were able to show that rhBMP6/ABC at a dose of 100 μg/mL accelerates

bone healing in patients undergoing HTO without serious adverse events

and with good tolerability compared with placebo alone. For the first time,

a BMP-based osteogenic implant was examined against a placebo for bone

healing efficacy in the trabecular bone surface, using an objective bone

mineral density measurement system.

ao. Univ.-Prof. in Dr. in Catharina Chiari, MSc

Author:

Catharina Chiari is head of the

Pediatric Orthopedic Team.

Additionally, she has a strong

interest in joint preservation

and regenerative medicine.

Currently she is the president

elect of the Austrian Orthopedic

Society (ÖGO).

References:

1

Vukicevic S, Sampath TK. Bone morphogenetic proteins: systems biology regulators. 1st ed. New

York: Springer International Publishing; 2017.

2

Grgurevic L, Oppermann H, Pecin M, Erjavec I, Capak H, Pauk M, Karlovic S, Kufner V, Lipar M,

Bubic Spoljar J, Bordukalo-Niksic T, Maticic D, Peric M, Windhager R, Sampath TK, Vukicevic S.

Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum

restores critical size segmental defects of ulna in rabbits. JBMR Plus. 2019;3(5):e10085.

3

Nemecek E, Chiari C, Valentinitsch A, Kainberger F, Hobusch G, Kolb A, Hirtler L, Trost C, Vukicevic

S, Windhager R. Analysis and quantification of bone healing after open wedge high tibial osteotomy.

Wien Klein Wochenschr. 2019;131(23–24):587–98.


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A Prediction Model for

Total Knee Arthroplasty

A collaborative group of researchers consisting of clinicians,

biostatisticians and anatomists initiated this study in order to

determine patient specific factors that could predict whether a

patient will have to undergo Total Knee Arthroplasty (TKA) within

two years. This work resulted in the establishment of an easily

applicable prediction model based on Artificial Neural Networks

(ANN), as well as in a publication entitled „Predicting Total Knee

Replacement from Symptomology and Radiographic Structural

Change Using Artificial Neural Networks—Data from the Osteoarthritis

Initiative (OAI)“ in the Journal of Clinical Medicine 1 .

As our clinic is a well renowned excellence center for total joint arthroplasty

(EndoCert), we are constantly concerned with improving patient care

by ongoing research. Considering the crucial role of timing of TKA, as well

as the progression of osteoarthritis as the underlying disease, we aimed to

determine factors that could predict TKA two years in advance. In this effort

clinicians from our department teamed up with a biostatistics professor

from Paracelsus Medical University and an anatomy professor from Mayo

Clinic College of Medicine. By using artificial neural networks we succeeded

to establish a prediction model that was able to correctly predict 80%

of the classified individuals to undergo TKA surgery, with a positive predictive

value of 84% and a negative predictive value of 73% 1 .

As commonly known, osteoarthritis of the knee contributes significantly to

the patient’s individual disability and impaired health-related quality of life,

and its treatment imposes a great socioeconomic burden, which is likely to

increase further, as we have shown in a previous study 2 .

Study:

Heisinger S, Hitzl W, Hobusch

GM, Windhager R, Cotofana S.

Predicting Total Knee Replacement

from Symptomology

and Radiographic Structural

Change Using Artificial

Neural Networks-Data from

the Osteoarthritis Initiative

(OAI). J Clin Med. 2020 May

1;9(5):1298.

Patients and Methods

In this study we included the radiographic and clinical data of 165 patients that

were enrolled in the Osteoarthritis Initiative study, representing a well-established

database for osteoarthritis research, which is accessible at nda.nih.gov 3 .

Patient data were analyzed longitudinally and changes were identified as

shown in Figure 1 (WOMAC total: 9.7 95% CI (7–12.5), p = < 0.0001; WOMAC

pain subscore: 0.5 (1.5–3), p = < 0.0001; quality of life 9.4 (6.3–12.6), p = <

0.0001; and pain intensity 1.5 (1–2), p = < 0.0001 ). While the radiographic

status constantly worsened between the timepoints prior to TKA, the symptomology

started to significantly worsen 1 year before surgery. In order to

develop a prediction model we used Artificial neural networks (ANNs) 1 .


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Figure 1: Longitudinal change of WOMAC totalscore, WOMAC pain subscore,

quality of life and pain intensity.

„Our model is based on easily accessible

patient data, making it easily applicable

in a primary care setting to evaluate the

need for TKA surgery within the next

two years and to give the patient an idea

about their status quo.“

Stephan Heisinger

In total 14 variables were included, and the most predictive group consisting

of pain intensity, Kellgren and Lawrence grades, WOMAC total score, use of

pain medication, and body mass index was identified by the integrated neural

network variable selection algorithm to have the best outcome performance

for predicting TKA surgery within 2 years. Furthermore, more than 250 neural

networks models with different network architecture were created, tested,

and protected against overlearning by splitting the patient sample into a

training, a verification, and a test sample, and monitored accordingly (ratio

2:1:1). We used two prediction thresholds for acceptance and for rejection,

i.e., if data of a subject fall into this area, no prediction is made. All analyses

were done using PASW 22 (IBM SPSS Statistics for Windows, Version 19.0.,

Armonk, NY, USA), StatXact 10 (Cytel Software 2013, Cambridge MA, USA),

Mathematica 7 (Wolfram Research, Inc., Mathematica, Version 7.0, Champaign,

IL, USA), STATISTICA for neural networks 1.2 and STATISTICA 13 (Hill, T. &

Lewicki, P. Statistics: Methods and Applications. StatSoft, Tulsa, OK, USA) 1 .

After the application of the variable selection algorithm and testing more

than 250 models, KL grades, WOMAC total score, body mass index measures,

pain intensity, and pain medication revealed the following performance: a

negative predictive value of 73% (52–88%), a positive predictive value of

84% (71–94%), and total percentage of correctly predicted knees of 80%

(69–89%) (1). To graphically visualize the neural network output and thereby

our prediction model we created a simplified and easily applicable chart, as

depicted in Figure 2.


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Figure 2: Graphic visualization of the neural network output illustrating the three-layer perceptron decision areas, including the variables pain intensity,

Kellgren and Lawrence grades, WOMAC total score, use of medication (for pain, aching, or stiffness in the knee), and body mass index into the neural

network. Areas represent: green area = no TKA within next 2 years, red area = TKA within next 2 years, and grey area = no prediction is made (1).

Results and Conclusion

Concludingly, our results indicate that significant worsening of pain, function,

and quality of life in the year prior to the TKA seems to be the more dominant

decision driving factor as compared to the radiographic structural changes

of the knee. Furthermore, we were able to establish a model that correctly

predicted 80% of the classified individuals to undergo TKA surgery within the

next 2 years, with a positive predictive value of 84%, and a negative predictive

value of 73% 1 . Our model is based on easily accessible patient data,

making it easily applicable in a primary care setting to evaluate the need for

TKA surgery within the next two years and to give the patient an idea about

their status quo.

Dr. Stephan Heisinger

Author:

Stephan Heisinger completed

his residency at the Department

of Orthopedics and Trauma Surgery

at the Medical University of

Vienna and is currently engaged

in a broad variety of research

fields with a focus on the

application of novel research

tools, such as Artificial Neural

Networks.

References:

1

Walzer SM, Toegel S, Chiari C, Farr S, Rinner B, Weinberg AM, Weinmann D, Fischer MB, Windhager

R.; A three dimensional model of zonally organized cartilaginous matrix in vitro. (in submission)

2

Kolb A, Robinson S, Stelzeneder D, Schreiner M, Chiari C, Windhager R, Trattnig S, Bohndorf K;

Vessel architecture in human knee cartilage in children: an in vivo susceptibility-weighted

imaging study at 7 T; Eur Radiol. 2018 Aug;28(8):3384-3392. doi: 10.1007/s00330-017-5290-1.

Epub 2018 Feb 26.

3

Kolb A, Benca E, Willegger M, Puchner SE, Windhager R, Chiari C.; Measurement considerations on

examiner-dependent factors in the ultrasound assessment of developmental dysplasia of the hip;

Int Orthop. 2017 Jun;41(6):1245–1250.(2)


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tPA Serum Antigen Levels Predict

ARDS in Polytraumatized Patients

Acute respiratory distress syndrome (ARDS) is a highly lifethreatening,

clinically defined, heterogeneous condition, regarding

both etiology and clinical course, which is triggered by

either a direct or an indirect insult to the lung, causing epithelial

and endothelial injuries. A variety of cellular and molecular

mechanisms contribute to the complex pathophysiology of ARDS,

including inflammation-induced coagulation and reduced fibrinolysis,

which favor excessive intra-alveolar fibrin deposition.

„The choice of the right treatment

strategy for polytraumatized patients

has to be based on an individual

risk stratification. The ambition of

contributing to the implementation

of a personalized polytrauma care

encouraged me to establish the

research group ‚Biomarkers‘ in 2011.“

Lukas Negrin

Study:

Negrin LL, Dedeyan M, Plesser

S, Hajdu S. Impact of Polytrauma

and Acute Respiratory

Distress Syndrome on Markers

of Fibrinolysis: A Prospective

Pilot Study. Front Med

(Lausanne). 2020 Jun 2;7:194.

ARDS is a common complication in polytrauma victims, particularly in

those with chest injuries, and a major cause of mortality and morbidity.

Its development is difficult to anticipate, as candidate biomarkers for the

prediction of ARDS were found not to be reliable for clinical use. By assessing

the time-dependent course of the serum antigen levels of the tissue

plasminogen activator (tPA) and the plasminogen activator inhibitor type-1

(PAI-1), which are both thought to reflect endothelial damage, we strived to

identify a cut off value or a clear curve characteristic that might predict the

development of ARDS in polytraumatized patients.

Our prospective study enrolled 28 consecutive blunt polytrauma survivors

(mean age, 38.4 [18-85] years; mean ISS, 35.1 [21-50]), who were directly

admitted to our level I trauma center within one year and transferred to the

ICU after initial treatment fulfilling the inclusion criteria minimum age of 18

years (1), Injury Severity Score (ISS) equal or higher than 16 (2), no anticoagulant

medication before trauma (3), and no treatment with tranexamic acid

(4) to avoid hyperfibrinolysis. To investigate the natural history of biomarker

levels, blood samples for tPA and PAI-1 analysis using Luminex multi-analyte

technology were taken at admission (day 0) and on days 1, 3, 5, 7, 10, 14,

and 21 during hospitalization, as long as the patient consented. Ten healthy

adults, who had responded our call for volunteers, were combined to our

control group. Only one blood sample was taken from them. Mann-Whitney

U-test, Chi-square test, and Wald test were performed to reveal significant

differences (p 3-fold higher than the mean level of the healthy control

group. After decreasing by 36% from day 0 to day 3 (p = 0.004), it basically

remained stable for up to 21 days (included).


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Figure 1: Individual tPA antigen levels

(grey lines) and mean tPA antigen level

(black bold line) in the study group.

Mean ± standard error of the mean

of tPA in healthy controls (green).

tPA is secreted into the plasma primarily by vascular endothelial cells through

two pathways: consecutive secretion, in which proteins are continuously

released as fast as they are synthesized, and regulated secretion, in which

newly synthesized tPA is stored at high concentrations in organelles and

secreted only in response to an appropriate stimulus such as a vascular injury.

We speculate that the physical impact at the time of injury and pathophysiological

processes hereafter might trigger enhanced consecutive secretion,

causing a long-term increase in biomarker levels, whereas regulated secretion

might further raise this „steady-state“ level for a short period in response to

additional endothelial damage.

At day 0 the mean PAI-1 antigen level was 2.6-fold higher than that of healthy

controls. Despite the 20% decrease from day 0 to day 5 (p = 0.007), it remained

elevated for at least three weeks. Mean PAI-1 antigen levels were higher in

poly trauma victims developing pneumonia compared to those not developing

the complication. The Wald test calculated p = 0.128 and 0.044 for the first

week and first three weeks from admission, respectively. Noteworthy, PAI-1

antigen levels increased between day 7 and day 10 in ten of 12 patients sustaining

pneumonia, all ten patients also suffering from ARDS.

A strong positive correlation between tPA and PAI-1 antigen levels within

the first week post-trauma was revealed, indicating that tPA and PAI-1

synthesis and their clearance from circulation by hepatic cells might be biologically

linked. The significant subject correlation over time between each

pair of tPA antigen levels might be explained by a predominant consecutive

secretion, ensuring high continuity in tPA antigen levels. Contrarily, correlation

coefficients between PAI-1 antigen levels were only significant in some


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Figure 2: tPA antigen levels (mean ± standard

error of the mean) in a subgroup of patients with

ARDS (ARDS 1 black bold line) and a subgroup

with no ARDS (ARDS 0, gray bold line). * indicates

significant difference between ARDS 1 and ARDS

0 group. Mean ± standard error of the mean of tPA

in healthy controls (green).

cases, which might be explained by its regulated secretion from platelets

caused by post-trauma triggers, as they vary between individuals.

Priv.-Doz. Dr. Lukas L. Negrin, PhD, MSc

Author:

Lukas Negrin has been working

as a specialist in trauma surgery

at the University Department

for Orthopedics and Trauma

Surgery since 2016. He completed

his habilitation in 2018

and deepened his knowledge

through numerous stays abroad.

His main focus lies on severely

injured and polytraumatized

patients, having already drawn

his interest early on during

his career. Currently he is the

head of the interdisciplinary

working group „Biomarkers in

polytrauma“, the head of the

research cluster „Polytrauma

and traumatic brain injury“, and

deputy head of the task force

„Polytrauma“ of the Austrian

Society for Trauma Surgery.

In our study group 11 patients developed ARDS (mean age, 29.7 [18-48]

years; mean ISS, 35.1 [29-50]), whereas 17 patients (mean age, 44.0 [18-85]

years; mean ISS, 33.7 [21-50] remained unaffected. As displayed in Figure 2,

the mean tPA antigen level was higher in polytraumatized patients developing

ARDS (group ARDS 1) than in those without ARDS (group ARDS 0) for

the entire observation period. A significant difference in tPA antigen levels

was observed at day 1 (p = 0.020), which was confirmed by the Wald test

(p = 0.004 for the period from day 0 to day 7 and p = 0.007 for the period from

day 0 to day 21).

Conclusion

Nevertheless, tPA antigen levels at days 0 and 1 were not suitable to predict

ARDS, as the levels observed at these days presented high variance due to

the different individual injury patterns. Particularly noticeable, however, is

the fact that in each polytrauma victim developing ARDS, the tPA antigen level

steadily increased or suffered a second increase up to the onset of the syndrome,

decreasing immediately thereafter. As each increase in tPA antigen

levels during hospitalization may indicate the imminent development of ARDS,

it should be considered as a warning sign for the timely implementation of

effective therapies that can prevent or at least weaken the manifestation of

the syndrome. Our findings indicate the potential of serum tPA antigen, when

repeatedly assessed, as a reliable biomarker to identify polytraumatized

patients at high risk of developing this syndrome. This approach is not only

cost- and resource-effective, but can also be easily implemented in the clinic

by using bedside tests. If included in the routine of daily blood sampling and

analysis, the assessment of tPA antigen levels would not result in significant

additional work and expenses.


3D Biochips for Research on

Inflammatory Musculoskeletal

Diseases

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43

In 2020, a cooperative project of researchers of the „Karl Chiari Lab

for Orthopaedic Biology“, co-coordinated with the „Division of

Rheumatology“, and the CellChipGroup at the Vienna University

of Technology developed a lab-on-a-chip system for analysis

of tissue-level remodeling in arthritic synovium, resulting in

the article entitled „Monitoring Tissue-Level Remodeling during

Inflammatory Arthritis Using a Three-dimensional Synoviumon-a-Chip

with Non-invasive Light Scattering Biosensing“ in RSC

Lab on a Chip (IF: 6.774). The work is a result of years of interdisciplinary

research at the interface of basic biological research

and bioengineering.

Study:

Rothbauer M, Höll G, Eilenberger

C, Kratz SRA, Farooq

B, Schuller P, Olmos Calvo I,

Byrne RA, Meyer B, Niederreiter

B, Küpcü S, Sevelda F,

Holinka J, Hayden O, Tedde

SF, Kiener HP, Ertl P. Monitoring

tissue-level remodelling

during inflammatory arthritis

using a three-dimensional

synovium-on-a-chip with

non-invasive light scattering

biosensing. Lab Chip. 2020

Apr 21;20(8):1461-1471. doi:

10.1039/c9lc01097a

Since 2019, the study of musculoskeletal tissues in microfluidic biochips is

a new additional research focus of tissue engineer Dr. Mario Rothbauer at

the „Karl Chiari Lab for Orthopedic Biology“ (KCLOB) of the Department of

Orthopedics and Trauma Surgery. The biochip team wants to use organotypic

tissue-like microsystems as three-dimensional disease models of the human

joint to recapitulate onset and progression of degradative and inflammatory

processes in arthritic diseases including rheumatoid arthritis (RA) and

osteoarthritis (OA), ranging from molecular pathways up to cellular and

tissue-level architecture and communication.

A systematic in vitro investigation of disease factors and co-factors that

mediate arthritic diseases, using three-dimensional human organotypic

biochips, may be key in identifying basic biological processes that govern

the onset and progression of musculoskeletal diseases. As active member

of the European Society for Alternatives to Animal Experiments (EUSAAT),

Dr. Rothbauer aims at a patient-derived approach for his team’s basic and

applied research, focusing on complimentary or even alternative methods to

animal experiments that include, i.e., the well-established collagen-induced

or collagen-antibody-induced rodent models (CIA/CAIA). The challenging

project idea to establish an animal-product-free synovial organoid biochip

platform for drug screening was awarded in 2019 with the Herbert Stiller

Prize of the Doctors Against Animal Experiments Association. 1

For several years, Dr. Rothbauer has focused on the development of microphysiological

sensor-integrated microsystems (i.e., microvasculature, blood brain

barrier, placenta) 2-4 , with special attention on synovium as inflammatory tissue


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3D Synovium-on-a-chip with scattering biosensing.

„Researchers were able to develop a

non-invasive lab-on-a-chip system for

the modelling of architectural changes

inside RA patient-derived synovial

organoids during inflammatory

remodeling. This constitutes as a

major technological advance as the

study presents the first translation

of human synovium organoids into

a miniaturized biochip format.“

Mario Rothbauer

in arthritic disease modelling. Currently his team is expanding this technological

platform for other musculoskeletal structures, including osteochondral,

adipose, and fibrous tissues. Essentially, patient-derived tissue microsystems

comprise microfluidic microchannels, isolated primary patient cells (i.e.,

fibroblast-like synoviocytes, chondrocytes, fibroblasts, or adipocytes), and

three-dimensional hydrogels as scaffolding material. In contrast to bioprinting,

where the basic shape is defined a priori by the printing technique, the microsystems

of the KCLOB form complex tissue-like structures resembling patient

joint tissues solely by the patient cells’ potential to remodel a bulk scaffold and

organize themselves into functional tissue-like structures.

Development of a Non-invasive Lab-on-a-chip System

Based on almost a decade of collaborative synovium-on-a-chip development,

basic researchers at the „Karl Chiari Lab for Orthopaedic Biology“

and the „Division of Rheumatology“ joined forces with Vienna University of

Technology, the University of Natural Resources and Life Sciences (BOKU),

and the TranslaTUM of Technical University of Munich, to develop a non-invasive

lab-on-a-chip system for the modelling of architectural changes inside

RA patient-derived synovial organoids during inflammatory remodeling. This

constitutes as a major technological advance as the study presents the first

translation of human synovium organoids into a miniaturized biochip format.

It demonstrated the formation of synovial organoids by in situ polymerization of

hydrogel with a high degree of position accuracy as well as a more reproducible

environment for organoid reorganization. Time-resolved light scattering

signals of 3D synovial organoids subjected to a TNF-α-mediated inflammatory

stimulus showed a significant scatter signal increase of 16% and

21% already at day 3 and 4, respectively. These alterations in light scattering

are a direct result of the structural and architectural changes within the

inflamed synovial organoid, featuring Cadherin-11-mediated thickening of

the synovial lining as well as the cellular network structures of the synovial

sublining with a strong Interleukin-6 and Interleukin-8 response.

Further Findings

The basic approach of combining multiple self-organizing biochip organoids

for crosstalk studies is currently under investigation for molecular RA and OA

research. While microfluidic models recapitulating molecular aspects of bone


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Chondro-Synovial Crosstalksing.

erosion between bone-derived cells and synoviocytes have been established,

RA’s synovial-chondral axis has not been realized using a microfluidic 3D

model based on human patient cells in vitro. Consequently, our collaborative

team has established a chip-based three-dimensional tissue co-culture model,

simulating the reciprocal crosstalk between individual synovial and chondral

organoids. Preliminary results recently published as BioRxiv preprint 5 already

indicate differential dynamics of organoid formation and remodeling in

co-cultures of chondro-synovial organoids. Particularly, a chondral organoid

in co-culture with synovium showed less condensation and VEGF secretion

in early cultivation phases, where – interestingly –a slightly elevated initial

inflammatory environment has been observed. As proof of principle, the

chondro-synovial biochip was then used to screen the effect of TGF-β3-induced

fibrotic remodeling under low serum conditions, which resulted in

a particularly strong condensation reaction of the synovial organoid, while

interleukin as well as matrix metalloprotease levels were comparable to less

fibrotic conditions. Based on these initial results, the effect of TNFα on the

architecture and soluble crosstalk is currently under investigation to learn more

about the molecular contribution of the chondro-synovial axis in arthritis.

Dr. Mario Rothbauer

Author:

Since 2019, Mario Rothbauer

has been a Post-Doc at the

‚Karl Chiari Lab for Orthopedic

Biology‘. In 2015, he received

his doctorate in biotechnology

from the University of Natural

Resources and Life Sciences

Vienna (BOKU). The main focus

of his research is the bioengineering

of human disease

models using organ- and labon-a-chip

technologies.

References:

1

Herbert Stiller Preis 2019 https://www.aerzte-gegen-tierversuche.de/de/news/aktuellenews/3005-herbert-stiller-foerderpreis-fuer-tierversuchsfreie-forschung-vergeben.

2

Eilenberger, C.; Rothbauer, M.; Selinger, F.; Gerhartl, A.; Jordan, C.; Harasek, M.; Schädl, B.; Grillari, J.;

Weghuber, J.; Neuhaus, W.; Küpcü, S.; Ertl, P. A Microfluidic Multisize Spheroid Array for Multiparametric

Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties. Adv. Sci. 2021,

n/a (n/a), 2004856. https://doi.org/https://doi.org/10.1002/advs.202004856.

3

Schuller, P.; Rothbauer, M.; Kratz, S. R. A.; Höll, G.; Taus, P.; Schinnerl, M.; Genser, J.; Bastus, N.;

Moriones, O. H.; Puntes, V.; Huppertz, B.; Siwetz, M.; Wanzenböck, H.; Ertl, P. A Lab-on-a-Chip

System with an Embedded Porous Membrane-Based Impedance Biosensor Array for Nanoparticle

Risk Assessment on Placental Bewo Trophoblast Cells. Sensors Actuators B Chem. 2020, 127946.

https://doi.org/https://doi.org/10.1016/j.snb.2020.127946.

4

Rothbauer, M.; Charwat, V.; Bachmann, B.; Sticker, D.; Novak, R.; Wanzenböck, H.; Mathies, R. A.; Ertl, P.

Monitoring Transient Cell-to-Cell Interactions in a Multi-Layered and Multi-Functional Allergy-on-a-

Chip System. Lab Chip 2019, 19 (11), 1916–1921. https://doi.org/10.1039/c9lc00108e.

5

Rothbauer, M.; Byrne, R. A.; Schobesberger, S.; Calvo, I. O.; Fischer, A.; Reihs, E. I.; Spitz, S.; Bachmann,

B.; Sevelda, F.; Holinka, J.; Holnthoner, W.; Redl, H.; Tögel, S.; Windhager, R.; Kiener, H. P.; Ertl, P.

Establishment of a Human Three-Dimensional Chip-Based Chondro-Synovial Co-Culture Joint

Model for Reciprocal Cross-Talk Studies in Arthritis Research. bioRxiv 2021, 2021.02.19.431936.

https://doi.org/10.1101/2021.02.19.431936.


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Biological Regeneration

in Early Osteoarthritis

In 2020, researchers of the Department of Orthopedics and Trauma

Surgery published an article entitled „Biological Regeneration of

Articular Cartilage in an Early Stage of Compartmentalized Osteoarthritis:

12-Month Results“ in the American Journal of Sports

Medicine 1 . The paper was the result from fruitful interdisciplinary

cooperation between clinical scientists, orthopedic surgeons, and

basic researchers. For her work, Dr. Martina Hauser-Schinhan was

awarded the Research Award of the „Österreichische Gesellschaft

für Orthopädie und Orthopädische Chirurgie (ÖGO)“ which honors

outstanding scientific contributions that have an impact on the

entire field of orthopedics.

Background

Osteoarthritis is the most common joint disease in the western world. It is

characterized by degenerative chondropathy, subchondral bone sclerosis,

and the presence of osteophytes. In contrast to focal cartilage defects,

osteoarthritis affects the entire joint. To date, the curative treatment of

osteoarthritis is limited to joint replacement surgery. However, this entails

certain surgical risks and limited implant survival, especially in young sportive

patients. The demands regarding regeneration, which are also made more

and more by older patients due to their increased activity, can often not be

met with artificial joints. In localized cartilage defects without osteoarthritis,

cartilage regeneration using different methods depending on the size of the

defect has already become clinical reality 2 .

Study:

Schinhan M, Toegel S, Weinmann

D, Schneider E, Chiari C,

Gruber M, Nehrer S, Windhager

R. Biological Regeneration of

Articular Cartilage in an Early

Stage of Compartmentalized

Osteoarthritis: 12-Month

Results. Am J Sports Med.

2020 May;48(6):1338–1346.

The autologous chondrocyte transplantation technique was already described

in 1994 by Brittberg et al. 3 . A further development of this approach is

MACT (matrix-assisted autologous chondrocyte transplantation), in which

chondrocytes are inserted into the cartilage defect on a carrier matrix. Due

to the poor results of this technique in arthritic joint conditions 4 , the patient

group with early osteoarthritis can only be treated with symptomatic therapy.

Methods

To find a solution for this group of patients, two large animal studies with

follow-up periods of 4 and 12 months, respectively, were carried out as

part of an EU-funded project 1,5 . In total, 48 Austrian mountain sheep were

operated twice. First, unicompartmental osteoarthritis was induced in the

stable joint by removing a standardized cartilage cylinder (7 mm defect with

a loading time of 12 weeks). The removed cartilage was used for the isolation

and cultivation of autologous chondrocytes. In a second procedure, the sheep


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Figure 1. (A) Intraoperative picture of the medial

femoral condyle after spongialization. The size of

the defect was standardized to remove the most

degenerated cartilage areas. Macroscopic image

of the (B) MACT group at the 12-month follow-up.

were separated into three different treatment groups (SPONGIO, MATRIX,

MACT) and one control group in which the cartilage defect and the surrounding

tissue were not treated.

In the sheep of the SPONGIO group, the cartilage of the load-bearing zone of

the medial femoral condyle was removed with a standardized oval punch and

a curette. The bone was then removed to a depth of 2.5 mm using a burr with

a spherical and a cylindrical attachment. This technique is called „spongialization“

6 . Bleeding was stopped with a thin layer of fibrin glue (Figure 1A).

„To date, the curative treatment of

osteoarthritis is limited to joint

replacement surgery. However, this

entails certain surgical risks and

limited implant survival, especially

in young sportive patients.“

Stefan Toegel

The animals in the MATRIX group received the same treatment as those in the

SPONGIO group, with the difference that a hyaluronic acid matrix was applied

on top of the fibrin layer. In the MACT group, the procedure was similar to that

in the MATRIX group. The difference was that the hyaluronic acid matrix was

colonized with autologous cultured chondrocytes (1 x 10 6 cells per cm 2 ) before

implantation. The macroscopic evaluation of the cartilage regeneration was

carried out using the Brittberg Score, whereas the histological evaluation was

performed using the Mankin Score and the O’Driscoll Score.

Results

Results of the control group showed a gradual, significant deterioration of

osteoarthritis over 4 and 12 months. There was no regeneration in the defect

area, and the adjacent cartilage showed increasing degeneration both

macroscopically and histologically. In all treatment groups, the regenerated

cartilage showed a zonal structure. After 4 months, the MACT group yielded

significantly better results than the other two regeneration groups (MATRIX,

SPONGIO) regarding macroscopic and histological parameters. The SPONGIO

group showed good chondrocyte quality after 4 months, but the cartilage

surface was very uneven. The MATRIX group was dominated by the formation

of regenerated tissue, which did not correspond to hyaline cartilage.

In the course of 4 to 12 months, an improvement in all regeneration groups

was detected. In 4 out of 6 sheep of the MACT group, the regenerate filled

the full height of the 2.5 mm deep and 20x10 mm large defect (Figure 1B).

Excessive regeneration above the normal cartilage cell height was not

present in any of the animals. Safranin O staining of the regenerated mate-


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Figure 2. Histological sections of regenerated

articular cartilage in the MACT group stained with

safranin O at the 12-month follow-up. Shown is

the center of the regenerated area at 2 magnifications.

Blood vessels crossing the tidemark

are marked with arrows, and the chondrocyte

arrangement in the deep zone of cartilage is

presented at a higher magnification. Scale bar:

200 µm (100x), 50 µm (400x).

rial revealed only a slight reduction in staining in MACT and SPONGIO groups

compared to healthy cartilage tissue. In contrast, the MATRIX group showed

strongly reduced staining. The tidemark was broken by blood vessels in all regeneration

groups. Chondrocytes arranged in columns in the central defect area

of the MACT group, suggesting the formation of hyaline cartilage (Figure 2).

In summary, the analysis of the histological evaluation of the 12-month

results showed significant superiority of the MACT and SPONGIO groups

compared to the MATRIX group.

Conclusion

Early OA was treated successfully in a large animal model, with the MACT group

showing the best regeneration after 4 months, persisting until 12 months with

even further improvement during this time. The good results of the SPONGIO

group can be attributed to the use of fibrin glue which was used to stop the

bleeding and standardize the model, and which might have also acted as a

matrix for cells. The poor results of the MATRIX group could be explained by the

sealing of the cancellous bone with flat fibrin glue preventing the migration of

stem cells from the bone into the matrix, suggesting implications for clinical

application in terms of matrix fixation. Further studies are needed to assess

whether these results can be directly transferred to the human knee joint.

Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel

References:

Author:

Stefan Toegel is head of the

„Karl Chiari Lab for Orthopaedic

Biology“. In 2015, he became an

Associate Professor at the Medical

University of Vienna and

obtained his habilitation in Cell

Biology in 2018. The main focus

of his research is on the pathomechanisms

of osteoarthritis.

1

Schinhan M, Toegel S, Weinmann D, et al. Biological regeneration of articular cartilage in an early

stage of compartmentalized osteoarthritis: 12-month results. Am J Sports Med. 2020;48:1338–46.

2

Aldrian S, Zak L, Wondrasch B, et al. Clinical and radiological long- term outcomes after matrixinduced

autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years.

Am J Sports Med. 2014;42:2680–2688.

3

Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous

chondrocyte transplantation. N Engl J Med. 1994;331:889–895.

4

Brix MO, Stelzeneder D, Chiari C, et al. Treatment of full-thickness chondral defects with Hyalograft

C in the knee: long-term results. Am J Sports Med. 2014;42:1426–1432.

5

Schinhan M, Gruber M, Dorotka R, et al. Matrix-associated autologous chondrocyte transplantation

in a compartmentalized early stage of osteoarthritis. Osteoarthr Cartilage. 2013;21:217–225.

6

Ficat RP, Ficat C, Gedeon P, et al. Spongialization: a new treatment for diseased patellae.

Clin Orthop Relat Res. 1979;144: 74–83.


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Total Hip Arthroplasties

after Chiari Pelvic Osteotomy

Total hip arthroplasty (THA) in untreated developmental dysplasia

of the hip (DDH) poses a challenge on the surgeon, as unusual

anatomy, deficient acetabular bone stock, proximal femoral

malrotation, leg length differences, and soft tissue contractions

need to be considered 1-3 . Studies report higher complication rates

and worse outcomes for THA in patients with DDH compared to

primary osteoarthritis 1, 4 . Controversy exists whether prior pelvic

osteotomies have negative effects on subsequent THA.

Many authors have noted that a successful CPO would facilitate the initial

situation for THA by improving the coverage of the femoral head, thus increasing

the bone stock for implantation and fixation of the acetabular component,

and therefore possibly leading to better clinical results 5-8 . The aim of our study

was to carry out a retrospective analysis focusing on the long-term results

of THA after prior CPO and to look at the rate of and reasons for early THA

failures and revision surgery.

Materials and Methods

We screened patient charts and X-rays from all patients who had undergone

a CPO at our department between 1953 and 1986 and invited them to attend

a follow-up examination. Of this consecutive series of 1536 CPOs, follow-up

was completed in 405 patients, with 504 CPOs after a mean time of 36 years

(±8; range, 22-54 years) 9 . The mean age of all patients at CPO was 25.3 years

(±12.8; range, 1.8-55.3). All patients who had already undergone THA (301 hips;

60%) at the time of follow-up examination were included in the study cohort.

Study:

Schneider E, Stamm T, Schinhan

M, Peloschek P, Windhager R,

Chiari C. Total Hip Arthroplasty

after Previous Chiari Pelvic

Osteotomy-A Retrospective

Study of 301 Dysplastic Hips.

J Arthroplasty. 2020

Dec;35(12):3638–3643.

Study Population and Patient Assessment

The study cohort comprised 221 female (90%) and 24 male (10%) patients.

The mean time between CPO and THA was 24.5 years (±10; range,

1 months-45.9). Revision operations were conducted on average 9.6 years

(±6.1; range 4 months-25.4 years) after conversion THA. Patient’s average

age at the time of revision was 57.9 years (±10; range, 33.2-78.5).

Follow up was performed after an average time of 12.7 years (±7.4; range,

2 weeks-36.9 years) after THA.

66 patients (81 THAs) followed our invitation and underwent clinical examination,

179 patients (220 hips) were interviewed on the phone. Information

on former medical history, date and side of THA, peri- and postoperative

complications, and revision surgery was collected and the Harris Hip Score

(HHS) concerning pain and function was completed.


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A

B

C

Figure 1: Case: male patient borne 1939;

An arthrodesis of his right hip was performed

in 1956 after seven years of conservative

treatment for tuberculosis. In 1979 his left hip

was treated with a Chiari PO for dysplasia with

subluxation. In 1992 the patient underwent THA

on the right side and in 1995 (16 years after PO)

on the left side. Latest FU 2017 (22 years after

THA): the patient’s satisfaction was good, the

Trendelenburg sign was positive, he showed

almost no pain and good mobility.

(A) Preoperative X-ray

(B) Post PO left (1979)

(C) 1 Year post -PO left (1980)

(D-E) implantation of THA 1995, X-ray

22 years post THA (2017)

D

E

Radiological Evaluation and Results

60 patients with 74 hips attended the radiological follow up. We compiled the

inclination angle of the acetabular cup, signs of radiolucency, ossifications,

and the presence of acetabular roof plasty. The overall survival (OS) of the THA

after 8-, 10-, 20- and 25 years was 95%, 93%, 76% and 68%, respectively.

„This retrospective study supports the

hypothesis that prior CPO does not compromise

the prerequisites for successful

conversion THA at a later stage.“

Eleonora Schneider

12% (N=37) of all patients underwent a revision THA procedure after an

average time period of 9.6 years (±6.1; range 4 months-25.4). Four patients

(11% of all revisions) underwent revision surgery within two years after THA.

Two patients had the acetabular component revised (50% of the early revision),

one for aseptic loosening after four months, the other for breakage of the acetabular

component after nine months. One patient had a total revision (25%)

for aseptic loosening and shaft fracture after 23.9 months. One patient underwent

revision surgery at another hospital due to unknown reasons (25%)

after twelve months. Of the remaining 33 patients one third needed revision

of the acetabular component (N = 11, 33%). Reasons for acetabular revision

surgery were twice aseptic loosening, one dislocation of the component and

once wear. In seven cases the patient could not specify the reason. Total revisions

were performed in nine patients (27%; 3 aseptic loosening, 1 infection,

1 luxation, 3 unknown). Seven hips (21%) had the head and inlay revised, the

reason being excessive wear in five of them, and no identifiable reason in the

other two. Three femoral stems had to be revised for unknown reasons (9%).

In one patient a Girdlestone surgery was performed due to infection (3%). Two

patients reported on a revision surgery on the phone but could not give any

valid details on reason or extent of the performed procedures (6%).

Neither patient’s age at the time of CPO (p= 0.199) nor the age at the time of

THA (p = 0.210) had significant influence on the incidence of revision surgery.

Out of 245 patients (301 hips), 81 were clinically investigated and nine of

them (11%) reported about early complications: two intraoperative femoral

fractures, two postoperative deep venous thrombosis, and five postoperative


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nerve lesions (1 N. femoralis, 1 N. peronaeus, 3 unspecified). The average

acetabular component inclination angle was 42° (±7.3; range 21°-63°).

Twelve hips (16%) showed an acetabular roof plasty, its presence had no

significant influence on the probability of revision surgery (p = 0.3368). Four

hips (5%) showed radiolucent lines around the acetabular component, but

none of them had revision surgery so far. In eight hips (11%) radiolucency

was detected around the stem, two (25%) of them were in the group of patients

who had already undergone revision surgery (one due to loosening of the stem,

the other due to polyethylene wear).

Discussion and Conclusion

We found a revision rate of 12% for THA after CPO at an average follow up of

12.7 years (±7.4; range, 2 weeks-36.9 years). The revision rate of 12% could

be partly owed to the long follow up interval, as complications probably had

time to develop, be detected, and addressed. Secondly, 62% of all conversion

THAs were performed prior to the year 2000 and may have resulted in higher

revision rates as older polyethylene components were used. However, the

revision rate compares to other studies in the literature seems to be at the

lower end.

Regarding the overall survival rate, we found out, that conversion THAs after

CPO (10-year OS 93%) would show a similar 10-year survival rate to primary

THA due to osteoarthritis, as reported in the Swedish (95,8%), US (95.2%)

and Australian (93.5%) registries. We could also show that our 10- and 20-

year survival rates (93% and 76%, respectively) were superior to the ones of

patients younger than 35 years with primary THA for osteoarthritis (87% and

61%, respectively) or untreated DDH (87% and 55%) 10,11 . This retrospective

study supports the hypothesis that prior CPO does not compromise the

prerequisites for successful conversion THA at a later stage.

References:

1

Garvin, K.L., et al., Long-term results of total hip arthroplasty in congenital dislocation and

dysplasia of the hip. A follow-up note. J Bone Joint Surg Am, 1991. 73(9): p. 1348–54.

2

Gill, T.J., J.B. Sledge, and M.E. Muller, Total hip arthroplasty with use of an acetabular reinforcement

ring in patients who have congenital dysplasia of the hip. Results at five to fifteen years.

J Bone Joint Surg Am, 1998. 80(7): p. 969–79.

3

Numair, J., et al., Total hip arthroplasty for congenital dysplasia or dislocation of the hip.

Survivorship analysis and long-term results. J Bone Joint Surg Am, 1997. 79(9): p. 1352–60.

4

Crowe, J.F., V.J. Mani, and C.S. Ranawat, Total hip replacement in congenital dislocation

and dysplasia of the hip. J Bone Joint Surg Am, 1979. 61(1): p. 15–23.

Dr. in Eleonora Schneider

5

Hoffman, D.V., E.H. Simmons, and T.W. Barrington, The results of the Chiari osteotomy.

Clin Orthop Relat Res, 1974(98): p. 162–70.

6

Hogh, J. and M.F. Macnicol, The Chiari pelvic osteotomy. A long-term review of clinical and

Author:

Eleonora Schneider is currently

completing her residency at the

Department of Orthopaedics and

Trauma Surgery at the Medical

University of Vienna. The main

focus of her research lies on

joint preserving techniques (hip

and knee).

radiographic results. J Bone Joint Surg Br, 1987. 69(3): p. 365–73.

7

Lack, W., et al., Chiari pelvic osteotomy for osteoarthritis secondary to hip dysplasia. Indications

and long-term results. J Bone Joint Surg Br, 1991. 73(2): p. 229–34.

8

Ohashi, H., K. Hirohashi, and Y. Yamano, Factors influencing the outcome of Chiari pelvic osteotomy:

a long-term follow-up. J Bone Joint Surg Br, 2000. 82(4): p. 517–25.

9

Chiari C, K.R., Windhager R, , Chiari and Salvage Osteotomy for the Treatment of Symptomatic

Acetabular Dysplasia, in The Adult Hip: Hip Preservation Surgery, B.P. Clohisy JC, Della Valle CJ,

Callaghan JJ, Rosenberg AG, Rubash HE, Editor. 2015, Wolters Kluwer: Philadelphia, PA.

10

Swarup, I., et al., Implant Survival and Patient-Reported Outcomes After Total Hip Arthroplasty in

Young Patients. J Arthroplasty, 2018. 33(9): p. 2893–2898.

11

Swarup, I., et al., Implant survival and patient-reported outcomes after total hip arthroplasty

in young patients with developmental dysplasia of the hip. Hip Int, 2016. 26(4): p. 367–73.


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The MOCART 2.0 Knee Score:

Morphological MRI for the

Assessment of Cartilage Repair

„Orthopedic surgeons and radiologists

with a special focus on musculoskeletal

radiology and cartilage repair joint

forces to develop a new and updated

version of the original MOCART score,

which would incorporate the developments

in cartilage repair surgery and

MR imaging alike. This culminated in

the publication of the MOCART 2.0 knee

score and atlas.“

Markus Schreiner

Symptomatic focal cartilage defects in young and active patients

pose a significant challenge to the orthopedic surgeon. Left untreated,

focal cartilage defects may increase in size and ultimately

progress to OA. With an increasing number of different surgical

techniques and scaffolds having become available, the comparison

of clinical outcome between these techniques becomes

increasingly important.

While clinical scores provide information on the overall joint-health and

patient satisfaction, morphological and quantitative MRI may provide

additional information on the status of the repair tissue. The qualitative and

quantitative assessment of cartilage repair tissue has been the focus of the

interdisciplinary research group between the Department for Orthopedics

and Trauma surgery and the High-Field MR Center of the Medical University

of Vienna for some time and lead to the introduction of the MOCART (Magnetic

Resonance Observation of Cartilage Repair Tissue) score.

Study:

Schreiner MM, Raudner M,

Marlovits S, Bohndorf K,

Weber M, Zalaudek M, Röhrich

S, Szomolanyi P, Filardo G,

Windhager R, Trattnig S.

The MOCART (Magnetic Resonance

Observation of Cartilage

Repair Tissue) 2.0 Knee Score

and Atlas. Cartilage. 2019 Aug

17:1947603519865308. doi:

10.1177/1947603519865308.

[Epub ahead of print]

However, since the introduction of the MOCART 2.0 knee score, MRI hardware

as well as MR sequences evolved. Similarly, surgical cartilage repair

techniques were refined, and the MOCART score did not reflect these new

developments. In addition, continuous use of the score for more than a

decade exposed some weaknesses of the scoring system. Hence, orthopedic

surgeons and radiologists with a special focus on musculoskeletal radiology

and cartilage repair joint forces to develop a new and updated version of the

original MOCART score, which would incorporate the developments in cartilage

repair surgery and MR imaging alike. This culminated in the publication

of the MOCART 2.0 knee score and atlas.

Main improvements of the score

The main improvements of the score include the elimination of the assessment

of adhesions, the variable „subchondral lamina“, and the variable

„synovitis“. Regarding the variables that were adapted, the variable „volume

of cartilage defect filling“ now allows for a more precise evaluation of defect

filling in 25% increments. Furthermore, hypertrophic filling of up to 150%

being is now being scored with the same scoring as complete repair, as it has

been previously shown that minor hypertrophy has no detrimental effects

on clinical symptoms or long-term outcome. The variable „integration“

was changed in a way that it now only assesses integration to neighboring


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53

1 Volume fill of cartilage defect Scoring

1 Complete filling OR minor hypertrophv: 100 to 150 % filling of total defect volume 20

2 Major hypertrophy ≥ 150 % (1_2a) OR 75 - 99 % filling of total defect volume (1_2b) 15

3 50 - 74% filling of total defect volume 10

4 25 -49% filling of total defect volume 5

5 < 25% filling of total defect volume (1_5a) OR complete delamination in situ (1_5b) 0

2 Integration into adjacent cartilage

1 Complete integration 15

2 Split-like defect at repair tissue and native cartilage interface ≤ 2mm 10

3 Defect at repair tissue and native cartilage interface > 2mm, but < 50 % of repair tissue length 5

4 Defect at repair tissue and native cartilage interface ≥ 50 % of repair tissue length 0

3 Surface of the repair tissue

1 Surface intact 10

2 Surface irregular < 50 % of repair tissue diameter 5

3 Surface irregular ≥ 50 % of repair tissue diameter 0

4 Structure of the repair tissue

1 Homogeneous 10

2 lnhomogeneous 0

5 Signal intensity of the repair tissue

1 Normal 15

2 Minor abnormal - minor hyperintense (5_2a) OR minor hypointense (5_2b) 10

3 Severely abnormal - almost fluid like (5_3a) OR close to subchondral plate signal (5_3b) 0

6 Bony defect or bony overgrowth

1 No bony defect or bony overgrowth 10

2 Bony defect: depth < thickness of adjacent cartilage (6_2a) OR overgrowth

< 50 % of adjacent cartilage (6_2b) 5

3 Bony defect: depth ≥ thickness of adjacent cartilage (6_2a) OR overgrowth ≥ 50 %

of adjacent cartilage (6_2b) 0

7 Subchondral changes

1 No major subchondral changes 20

2 Minor edema-like marrow signal – maximum diameter < 50 % of repair tissue diameter 5

3 Severe edema-like marrow signal – maximum diameter ≥ 50 % of repair tissue diameter 10

4 Subchondral cyst ≥ 5mm in longest diameter (7_4a) or osteonecrosis-like signal (7_4b) 0

Figure 1: Scoring sheet of the Magnetic Resonance

Observation of Cartilage Repair Tissue (MOCART)

2.0 knee score.

cartilage and not underlying bone. Surface irregularities are now subdivided

with respect to cartilage repair length rather than depth to reduce overlap

with the variable filling of the repair tissue. The variable „structure of the

repair tissue“ was kept unchanged. The variable „signal intensity of the repair

tissue“ was adapted to better reflect the reality of current imaging protocols

in clinical routine. Whereas it used to be common practice to measure both

a dual T2w TSE and a T1 3D GRE fs sequence at the time of the introduction

of the original MOCART score, nowadays most protocols do not contain both

sequences anymore. Hence, the signal intensity of the repair tissue is now

recommended to be assessed on a single PDw TSE sequence. Both hypointense

and hyperintense signal changes can now be scored in one variable.

To acknowledge the recent focus on subchondral bone, assessment of bony

defects and subchondral bone is more prominently featured in the MOCART

2.0 knee score. The introduction of the variable „bony defect or bony overgrowth“

allows for the scoring of bony defects as well as intrachondral

osteophytes, which are commonly observed after microfracture and were not

accounted for in the original MOCART score. Furthermore, the variable „sub-


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54

Figure 2: Sagittal proton-density-weighted turbo spin-echo image without fat saturation (A) and

coronal proton-density-weighted turbo spin-echo image with fat saturation of a 31-year-old

female patient 29 months after MACI of a grade IV cartilage lesion of the medial femoral condyle

of the right knee with an overall MOCART 2.0 knee score of 80 points.

chondral bone“ was changed to the variable „subchondral changes“ and now

incorporates the assessment of the presence of bone-marrow edema-like

marrow signal, which can be further subdivided into minor and severe, as

well as the presence of subchondral cysts and osteonecrosis like signals.

Dr. Markus Schreiner

Author:

Markus Schreiner has been a

resident at the Department of

Orthopedics and Trauma Surgery

at the Medical University

of Vienna since 2016 and is a

member of the biomedical MRimaging

Cluster of orthopedic

disorders. Since 2019 he has

coordinated the scientific collaborations

between the Orthopedic

department and the High

Field MR Centre (Prof. Siegfried

Trattnig) at the Medical University

of Vienna, together with

Sebastian Apprich M.D.

Within the biomedical MRimaging

cluster, his research

focuses on the development

and implementation of MR

imaging techniques used for

qualitative and quantitative assessment

of cartilage, tendons,

and intervertebral discs as well

as clinical projects on cartilage

repair surgery.

Evaluation of the MOCART 2.0

The new MOCART 2.0 knee score was then used by two senior radiologists

and two junior radiologists with little or no previous exposure to musculoskeletal

radiology to assess the MRI examination of 24 patients after MACT. All

MRI imaging studies were performed on 3T MR systems with dedicated knee

coils. The average age of the included 24 patients (11 female, 13 male) was

34.8 ± 10.9 years. The median postoperative follow-up interval was 2.3 years.

Median lesion size was 3.8cm2, ranging from 0.9. to 12cm.

When designing the MOCART 2.0 knee score, special emphasis was put on

reproducibility. To ensure that scorings would be consistent between readers

and therefore studies, an atlas was developed alongside the score, which

contains example images for every possible scoring of the MOCART 2.0. knee

score. To assess whether use of this additional resource would provide any

additional value, the inexperienced readers assessed all imaging studies for

a second time after a four-week interval, with the difference that for the second

reading, access to the atlas of the MOCART 2.0. knee score was granted.

The expert readers demonstrated almost perfect overall intrarater

(ICC=0.88, p


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The Genetic Landscape

of Axonal Neuropathies:

Focus on MME

55

Study:

Senderek J, Lassuthova P,

Kabzińska D, Abreu L, Baets J,

Beetz C, Braathen GJ, Brenner

D, Dalton J, Dankwa L, Deconinck

T, De Jonghe P, Dräger B,

Eggermann K, Ellis M, Fischer

C, Stojkovic T, Herrmann DN,

Horvath R, Høyer H, Iglseder

S, Kennerson M, Kinslechner

K, Kohler JN, Kurth I, Laing

NG, Lamont PJ, Wolfgang N

L, Ludolph A, Marques W Jr,

Nicholson G, Ong R, Petri

S, Ravenscroft G, Rebelo A,

Ricci G, Rudnik-Schöneborn S,

Schirmacher A, Schlotter-

Weigel B, Schoels L, Schüle R,

Synofzik M, Francou B, Strom

TM, Wagner J, Walk D, Wanschitz

J, Weinmann D, Weishaupt

J, Wiessner M, Windhager

R, Young P, Züchner S,

Toegel S, Seeman P, Kochański

A, Auer-Grumbach M. The

genetic landscape of axonal

neuropathies in the middleaged

and elderly: Focus on

MME. Neurology. 2020 Dec

15;95(24):e3163-e3179

The genetic diversity of Charcot-Marie-Tooth (CMT) syndrome,

a hereditary motor-sensory neuropathy, is still not fully explored.

CMT consists of several subtypes, however, CMT1 (demyelinating

form) and CMT2 (axonal form) are the most common types 1 .

The disease onset of CMT usually starts in childhood, but lateonset

forms have been described 2 . For the latter, rare variants

in MME, encoding the metalloprotease neprilysin, have been

published earlier by our group 3 . Here, this international and interdisciplinary

study reveals new gene variants of CMT2 for midelderly

and individuals older than 65 years, leading to late-onset

manifestations.

To investigate unexplained axonal neuropathies and disease onset in

patients older than 35 years, 230 individuals were included into this study.

From 2012 until 2016 clinical and electrophysiological screenings were

conducted and genetic analyses were performed. For the latter, DNA was

isolated from patient’s blood and samples underwent either whole-exome

sequencing (WES, n = 126) or MME single-gene sequencing (n = 104).

Furthermore, the concentration of neprilysin was measured by ELISA in

patients’ blood.

Genetic Causes Identified by WES

126 DNA samples were screened by WES and for 23 samples rare nonsynonymous

likely pathogenic variants were identified, related to CMT2

or resembling the CMT2 phenotype. The most frequently involved gene

was MME (n = 8), followed by LRSAM1 (n = 3), MPZ (n = 2), TTR (n = 2)

and HMBS, VCP, WARS, AARS, DHTKD1, GARS, HARS and HSPB8 (n = 1,

respectively). Concerning the MME gene, three patients carried rare

biallelic variants consistent with autosomal recessive inheritance, while

five patients carried single heterozygous loss-of-function (frameshift,

nonsense or splice) variants.

Targeted sequencing of the MME gene

104 DNA samples were screened independently for MME variants and

revealed private or rare variants in 14 patients. One individual was consistent

with autosomal recessive inheritance, four patients carried single


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56

Late-onset gnomAD all gnomAD European HZN GENESIS

neuropathies exomes exomes exomes exomes

Number of 230 123,136 55,860 11,225 3,793

samples (alleles) (460) (246,272) (111,720) (22,500) (7,586)

Loss-of-function 9 (0.01957) 172 (0.0007024) 91 (0.0008187) 15 (0.0000667) 3 (0.0004653)

variants * P = 9.35E-11 P = 4.33E-10 P = 4.82E-10 P = 1.14E-9

Rare missense 14 (0.03043) 1,562 (0.006361) 592 (0.005319) 206 (0.009156) 50 (0.006591)

variants # P = 2.3E-6 P = 3.22E-7 P = 0.00015 P = 0.00001

Rare, serious 13 (0.02826) 926 (0.003771) 414 (0.003720) 131 (0.005822) NA

missense variants † P = 4.78E-9 P = 3.70E-8 P = 6.89E-6

p.Pro15 6Leufs * 14 2 (0.004348) 62 (0.0002525) 33 (0.0002965) 6 (0.0002667) 2 (0.0002036)

P = 0.00652 P = 0.0092 P = 0.01 P = 0.018

p.Tyr347Cys 8 (0.01739) 128 (0.0005202) 117 (0.001049) 41 (0.001822) 10 (0.001318)

P = 2.64E-10 P = 5.88E-8 P = 5.36E-6 P = 2.83E-60

p.Met8Val 26 (0.05652) 4,041 (0.01641) 2,719 (0.02435) 544 (0.02418) NA

P = 8.76E-8 P = 0.0001 P = 0.00025

p.Val345lle 4 (0.008696) 463 (0.001882) 354 (0.003174) 67 (0.002978) NA

P=0.012 P = 0.061 P = 0.054

p.Gly225Ala 0 (0) 393 (0.001635) 230 (0.002126) 78 (0.003467) NA

P = 0.99 P = 0.99 P = 0.99

Table 1: Frequencies of MME variants in cases and control.

Figure 1: Manifestations of MME variants ; adapted from 4

(A) Disease severity of cases with autosomal recessive and assumed autosomal dominant inherited MME variants are

shown as proportional distribution (Scores: mild = 1, very severe = 4).

(B) Boxplots comparing neprilysin levels in EDTA plasma obtained from healthy controls (n = 22), late-onset neuropathy

patients without MME variants (n = 34), serious MME variants (n = 15), and the p.Met8Val low-frequency polymorphism

(n = 9).


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57

rare heterozygous loss-of-function variants, and nine patients carried rare

heterozygous missense variants.

„For individuals older than 65 years we

observed that MME variants may act as

completely penetrant recessive alleles

but also lead to dominantly inherited

susceptibility to axonal neuropathies.“

Katharina Pichler

In Table 1 frequencies of MME variants of 230 individuals (cases and controls)

with late-onset neuropathies were compared to all exomes of gnomAD,

European descent exomes of gnomAD, the exomes of Helmholtz Zentrum

München or exomes of GENESIS. The comparison to control datasets

revealed that, for instance, heterozygous MME loss-of-function variants

showed a statistically significant enrichment in our screening cohort.

Clinical manifestations of MME variants

Although the disease manifested with advanced age, it showed a progressive

and severe behaviour. Patients complained of neuropathic pain, with muscle

wasting and weakness with sensory deficits in the lower legs. CMAP amplitudes

were usually below the normal range (


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Distal Femur Replacement –

Differences between Oncologic

and Non-Oncologic Conditions

[…] this study is of vital importance since

it is the first one to show the differences

between patients with and without

oncologic conditions undergoing DFR.

Cementation might be a better fixation

method for patients with oncologic

condition […]

Kevin Staats

Study:

Staats K, Vertesich K, Sigmund

IK, Sosa B, Kaider A, Funovics

PT, Windhager R. Does a

Competing Risk Analysis Show

Differences in the Cumulative

Incidence of Revision.

Clin Orthop Relat Res. 2020

May;478(5):1062–1073.

The use of megaprosthetic reconstruction of the extremities

originated from extended bone loss due to wide resection of

bone or soft-tissue tumors. However, due to the growing number

of primary total knee arthroplasty (TKA) and the expanding life

expectancy of patients, information about the outcome of distal

femur replacement (DFR) due to non-oncologic conditions in

revision-TKA (rTKA) is becoming more and more important.

We therefore raised the question, whether differences in patient

population and DFR fixation (cemented or cementless) have an

impact on the outcome after DFR.

In a retrospective cohort study, we analyzed patients undergoing DFR due

to oncologic and non-oncologic indications from 1986 to 2016. We were

able to include 229 patients, in total of which 183 patients underwent DFR

due to oncologic, and 46 patients due to non-oncologic conditions. Patients

undergoing DFR due to oncologic reasons were – as expected – significantly

younger than the cohort with non-oncologic conditions. Cementless fixation

was more often performed in oncologic cases, whereas in the non-oncologic

cohort cementation and cementless fixation were almost equally distributed.

Table 1 displays the basic demographics and differences between

patients with oncologic and non-oncologic reasons undergoing cemented

and cementless DFR. The decision whether patients received cemented or

cementless distal femoral replacements was not based on a strict algorithm.

We strongly believe the indications for cemented or cementless fixation have

not changed dramatically in our institution over time. Usually, cementless

fixation is preferred in young, active patients and in those with primary bone

tumors, whereas cemented fixation is mainly used in older patients with

expected poor bone quality or metastatic bone lesions. However, bone quality

and patient activity level were not assessed for the entire patient cohort.

Regardless of which distal femoral replacement system was used, it always

consisted of a cemented or cementless modular component fitting the metaphyseal

and diaphyseal portion of the distal femur.

Patients and Method

In our study, the 149 patients receiving cementless fixation were younger

(median age 31 years [range 16-55 years]) than the 80 patients with cemented

distal femoral replacement (median age: 54 years [range 27-72 years];


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Figure 1: Example of a Distal Femur Replacement

due to a low comminuted periprosthetic distal

femur fracture.

p = 0.001). The endoprosthetic systems used in this study are a fixed-hinge type

of prosthesis (Howmedica Modular Replacement System, Kiel, Germany)

and, beginning in 1999, a modified rotating-hinge version of the fixed-hinge

type (Global Modular Replacement System, Stryker, Kalamazoo, MI, USA)A.

Instead of using a Kaplan-Meier analysis, we performed a competing risk

analysis (Fine-Gray model) for the evaluation of incidence of revision surgery

after DFR. Since patients with oncologic conditions and patients undergoing

DFR due to rTKA have a higher mortality rate than the general population,

we defined “death” as a competing event for revision surgery. Competing risk

analyses have proven to be more accurate than Kaplan-Meier calculations

in patients with higher mortality rates because life expectancy might be too

short for experiencing a revision surgery.

Results

The median follow-up duration in the overall cohort was 85 months (range

0.1-391 months). Thirty-two percent (58 of 183) of oncologic patients and

48% (22 of 46) of non-oncologic patients underwent cemented distal femoral

replacement, representing 35% of the overall cohort. During the observation

period, 30% of the patients (69 of 229) died after DFR, 64 of whom were in

the oncologic cohort. According to the International Society of Limb Salvage’s

classification system, complications leading to revision surgery during the

observation period (1983 to 2016) were either soft-tissue failure (Type 1) in

24 patients (16 with oncologic disease), aseptic loosening (Type 2) in 35 patients

(30 with oncologic disease), structural failure (Type 3) in 19 patients (17 with

oncologic disease), infection (Type 4) in 33 patients (27 with oncologic disease),

or tumor progression (Type 5) in five patients.


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Dr. Kevin Staats

Statistical Analysis

The competing risks analysis revealed cumulative revision incidences of

26% (95% CI, 20.3%-31.9%) at 12 months, 37.9% (95% CI, 31.3%-44.4%)

at 24 months, 52.6% (95% CI, 45.1%-59.5%) at 5 years, and 58.2% (95% CI,

50.1%-65.4%) at 10 years for all patients in this study.

Author:

Kevin Staats started his residency

at the Department of

Orthopedics and Trauma Surgery

at the Medical University

of Vienna in 2016. His research

interests are total joint replacement

and revision arthroplasty

and he is deputy director of the

Arthroplasty Research Cluster.

Dr. Staats was awarded the

Ines Mandl Research Fellowship

and had the opportunity to

expand his clinical and research

focus at the Hospital of Special

Surgery/Weill Cornell University,

New York City. His research on

the antimicrobial effect of electrochemically

modified titanium

surfaces received institutional

funding by CEST Wr. Neustadt

through the FFG-COMET program.

Dr. Staats is currently an

extended board member of the

Austrian Orthopedic Society as

the representative for Austrian

orthopedic residents.

The multivariate analysis adjusted for important variables such as age, sex,

disease (oncologic versus non-oncologic), cementation, and year of surgery

clearly showed that patients with oncologic diagnoses have a lower risk of

undergoing revision surgery than patients with non-oncologic diagnoses (HR

0.44 for oncologic versus non-oncologic; 95% CI, 0.22-0.87; p = 0.02).

Additionally, the multivariate Fine and Gray model yielded an interaction

between the two prognostic factors of oncologic disease and cementation

(p = 0.03), revealing a reduction in the risk of revision with cemented fixation

in patients with oncologic disease (HR 0.53; 95% CI, 0.29-0.98).

According to our results, implant fixation may have a major impact on the

risk of revision surgery in patients with oncologic disease.

Cementation did not have any effect on the cumulative incidence of revision

surgery for any cause in our overall cohort. However, cemented distal femoral

replacements were less frequently revised because of aseptic loosening than

cementless endoprostheses in patients who underwent surgery for oncologic

indications (with an incidence of 6.9% (95% CI, 2.5%-14.3%) at 2 years and

8.6% (95% CI, 3.4%-16.8%) at 5 years, compared with 11.8% (95% CI, 7%-

17.9%) and 19.7% (95% CI, 13.2%-27.1%; p = 0.04), respectively. Due to the

rate of aseptic loosening of cementless implants being almost 12% in the

first two years, we believe that initial implant fixation or osseointegration was

not achieved in patients with oncologic disease.

In conclusion, this study is of vital importance since it is the first one to

show the differences between patients with and without oncologic conditions

undergoing DFR. Cementation might be a better fixation method for

patients with oncologic condition, however further studies are needed to

prove this hypothesis.


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62

Biomechanical Evaluation of Intramedullary

Jones Fracture Fixation

Jones fractures or meta-diaphyseal fractures of the proximal fifth

metatarsal (zone II) have a notoriously high rate of nonunion and

delayed union with conservative treatment. Therefore, surgical

fixation using an intramedullary screw is currently recommended

as the primary treatment for active patients, as well as recreational

and professional athletes. Besides early functional mobilization

and a faster return to sports, higher rates of primary fracture

healing have been demonstrated in clinical studies. Nevertheless,

implant choice is a matter of concern since active patients are

prone to failure including nonunion, screw failure, and refracture.

A variety of screw types have been used to treat Jones fractures. Currently,

neither clinical nor biomechanical studies comparing different screws

provide decisive results, so there is no consensus on the ideal screw design

or diameter. Cannulated screws are easy to use and insert but may have a

detrimental biomechanical behavior compared to solid screws. Standard

solid screw insertion can be technically demanding and a prominent screw

head can lead to discomfort and pain at the base of the fifth metatarsal.

A countersinkable or low-profile screw head may reduce this potential

complication, but recent advances in implant design have even developed

fracture-specific screws with combined properties for the treatment of

Jones fractures. To seek clarification in the biomechanical aspects of recent

screw designs regarding the treatment of Jones fractures, this study compares

a solid, fracture-specific screw with a cannulated headless compression

screw in a biomechanical Jones fracture fixation model by simulating initial

postoperative weight-bearing and ultimate loading.

Study:

Willegger M, Benca E, Hirtler L,

Kasparek MF, Bauer G, Zandieh

S, Windhager R, Schuh

R. Evaluation of Two Types of

Intramedullary Jones Fracture

Fixation in a Cyclic and

Ultimate Load Model. J Orthop

Res. 2020 Apr;38(4):911–917.

doi: 10.1002/jor.24530.

Materials and Methods

Ten matched pairs of fresh human foot specimens were used for this biomechanical

study. The specimens were obtained from voluntary donors who

consented to donate their body for research and teaching purposes to the

Center for Anatomy and Cell Biology, Medical University of Vienna during

lifetime. Donor age ranged from 64 to 92 years (mean 78.8 ± 8.7 years). The

specimens were stored at –80°C and thawed at +4°C 48 hours prior to

testing in order to prevent tissue dehydration. After screening for previous

injuries or surgeries at the fifth metatarsal, all specimens proved valid for

inclusion. Bone mineral density (BMD) was assessed prior to biomechanical

testing by use of dual-energy X-ray absorptiometry (DEXA). Scans of the

calcaneus were reported as g/cm 2 . To minimize possible left-right bias, one

foot of each pair was assigned to fracture-specific Jones screw fixation


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Figure 1: Biomechanical test setup: The potted fifth

metatarsal specimen was fixed into a machine vice

on an adjustable platform. A metal rod attached to

the loading frame was used for force transmission

in a plantar to dorsal direction. Light-reflecting

hemispherical markers were glued onto the distal

part of the Jones fracture specimen and onto the

pot and rod for kinematic tracking.

„To seek clarification in the biomechanical

aspects of recent screw

designs regarding the treatment of

Jones fractures, this study compares

a solid, fracture-specific screw with

a cannulated headless compression

screw in a biomechanical Jones

fracture fixation model.“

Madeleine Willegger

(Jones Screw; Arthrex Inc., Naples FL, USA) (JFXS group) and the contralateral

foot was assigned to conventional cannulated headless compression

screw fixation (HCS; DePuySynthes, Solothurn, Switzerland) (HCS group),

with equal numbers of right and left feet in each group. The fifth metatarsals

were further dissected and disarticulated from the feet. Jones fractures at

the meta-diaphyseal junction were created using an oscillating saw. Both

screw types were inserted according to the manufacturer’s instructions. The

intramedullary screw had to „fit and fill“ the medullary canal with the threads

across the fracture site. HCS were available in diameters 4.5-mm and 6.5-

mm, and Jones Screws were used in diameters 4.5-mm and 6.0-mm.

An experimental setup was designed to simulate the postoperative in vivo

loading conditions after surgical Jones fracture treatment. The specimens

of the fifth metatarsal were placed with their proximal aspects in Wood’s

metal in specially fabricated custom-made steel cups, which were fixed

in a machine vice. The biomechanical testing was performed with an 858

Mini Bionix ® (MTS ® Systems Corporation, Eden Prairie, MN). (Figure 1) A

metal rod was used for force transmission onto the plantar aspect of the

metatarsal head. An opto-electronic motion capture system (Smart-E; BTS

Bioengineering, Milan, Italy) with four cameras was used during the loading

process to track kinematic changes. Specimens were loaded with a cyclic

load mean of 12 N at 0.5 Hz for 1000 cycles. The number of load cycles

was chosen based on the loading rate for a physiologically normal lower

limb, which is approximately 5000 cycles per day. One thousand cycles per

day were assumed to realistically simulate post-operative loading during


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64

Figure 2: Box plots representing the ultimate

load to failure, in Newton, per screw.

The horizontal line indicates the median,

the box extends from the 25th to the 75th

percentile, and the bars indicate the largest

and smallest observed value.

early active rehabilitation. After completion of cyclic loading, an ultimate

load to failure test was performed. Failure was defined as gross failure due

to fracture, screw bending or breakage, or dorsal angulation of the distal

fragment exceeding 10°. Stiffness (slope), displacement, angulation, and

ultimate loads were compared between both groups. Modes of failure were

classified and analyzed with reference to screw type.

Results

There was no significant difference in stiffness and machine displacement

between fifth metatarsals fixed with the solid Jones Fracture-specific

screw (JFXS group) or the cannulated headless compression screw (HCS

group) at any point during the cyclic loading (stiffness:0.324 ≤ p ≤ 0.986;

displacement: 0.131 ≤ p ≤ 0.635). Interfragmentary angulation increased

from 1st to 1000st cycle in both groups, but not statistically significant.

According to preliminary failure criteria, we found a construct survival of

100% in the JFXS group and 90% in the HCS group during cyclic loading.

Priv.-Doz. in Dr. in Madeleine Willegger, FEBOT

Author:

Madeleine Willegger started

her career at the Department

of Orthopaedics at the Medical

University of Vienna in 2014.

She is a specialist in Paediatric

Orthopaedics and Foot and

Ankle Surgery. Dr. Willegger is

Fellow of the European Board

of Orthopaedics and Trauma

Surgery (FEBOT). Her research

activity covers biomechanical

and arthroscopic studies on the

foot and ankle, evaluation of

prognostic factors in soft tissue

sarcoma, and clinical studies on

lower limb rotation in children.

The mean ultimate load to failure was 236.9 ± 107.8 N in the JFXS group

compared with 210.8±150.7 N in the HCS group. Intergroup difference was

not statistically significant (p = 0.429). The most common mode of failure

in HCS constructs was proximal screw head cut out (n = 6, 60%), followed

by loosening of the screw head (n = 3, 30%). In JFXS constructs metatarsal

shaft fracture was the most observed mode of failure (n=4, 40%), followed

by screw head cut out (n = 3, 30%). There was no statistically significant

difference of BMD between the groups. BMD showed a positive correlation

with the pooled ultimate load (R = 0.580, p = 0.007) for all constructs. It

correlated negatively with angulation (angulation at first loading cycle:

R=−0.676, p = 0.003), which was significant for every load cycle among

all tested constructs (angulation at cycle 10: R=−0.552, p=0.002; cycle

100–1,000: p≤0.001).

Conclusion

This biomechanical study shows that both screw constructs (solid fracture-specific

screws versus conventional cannulated headless compression

screws) provide equal ultimate loads and stiffness in a Jones

fracture fixation model. In addition, low BMD seems to be related to a

diminished primary stability and impaired ultimate load in intramedullary

Jones fracture fixation.


TOP-Studien

65

Development of a New

Electronic Navigation System

Development of an electronic navigation system for elimination

of examiner-dependent factors in the ultrasound screening for

developmental dysplasia of the hip in newborns: The presented

paper demonstrates an innovative problem solution to improve

the quality of sonographic hip dysplasia screening, which is

established in the mother-child-pass screening program. It was

developed based on scientific preliminary work at the Medical

University of Vienna.

„Compared to established aids such as

positioning aids for the baby (cradles)

and mechanical transducer guiding

devices, the main advantage of the

presented system is the accurate

detection of the pelvic position.“

Alexander Kolb

Sonography of the infant hip, according to Graf, is the gold standard for early

diagnosis of hip dysplasia 1 . Despite this standardization, examinerdependent

influences on the measurement results have been repeatedly

discussed 2,3 , with tilt of the transducer position in relation to the hip joint

(tilt error) being of importance 4 . In addition to structured training of the

examiners, the aforementioned tilt errors were addressed in particular by

aids such as a positioning aid for the baby (cradle) and a mechanical transducer

guiding device („Sono Guide“ according to Graf). The importance of

these tilt errors was demonstrated using an opto-electronic motion capture

system to capture the transducer position 4 . However, one limitation of the

opto-electronic system is due to its sensor size, making it impossible to capture

the pelvic/hip position of the baby. Thus, analogous to the mechanical

transducer guiding device („Sono Guide“), a defined transducer orientation is

achievable, but the pelvic/hip position remains an uncertainty factor.

Study:

Kolb A, Chiari C, Schreiner M,

Heisinger S, Willegger M, Rettl

G, Windhager R. Development

of an electronic navigation

system for elimination of

examiner-dependent factors

in the ultrasound screening for

developmental dysplasia of

the hip in newborns. Sci Rep.

2020 Oct 2;10(1):16407.

The aim of this work is the development of a new electronic navigation system,

which is able to detect both pelvic/hip position and transducer position,

and thus contributes to the minimization of examiner-dependent influences

in the sense of relative transducer tilts.

Materials and Methods

A novel electronic navigation system was used to quantify relative tilts

between the pelvis and the transducer (tilt errors) as part of the Graf sonographic

hip dysplasia screening 5,6 : This system consists of two spatial

position sensors, with one sensor fixed to the transducer and the second

sensor epicutaneously attached centrally dorsally over the os sacrum (see

Figure 1). The two sensors are each composed of an accelerometer, a gyroscope

and a magnetometer. Software calculates the relative tilt between the

pelvis and the transducer at three angles (in the frontal, axial, and sagittal

planes) and displays it visually as a navigation aid for the examiner 6 . For

each of the children examined, a sonogram was prepared without the aid of


TOP-Studien

66

Figure 1: Illustration of the position of the

two 3D spatial position sensors: spatial

position sensor epicutaneously centrally

dorsally over the os sacrum for recording

the pelvic position (white arrow (A and B)),

transducer with 3D-printed adapter and

spatial position sensor (white star (A)).

Figure 2: Illustration of the relative tilt

angles between the pelvis/hip joint and the

transducer in the frontal plane (roll) and

axial plane (pitch): (a) transducer alignment

using the navigation system, (b) conventional

alignment of the transducer without

navigation system.

the electronic navigation system (conventional), as well as a sonogram using

the electronic navigation system (navigated), whereby here the transducer

was aligned by the examiner according to the displayed measurement data.

In both sonograms, care was taken to ensure that the sonographic criteria

according to Graf were met.

Results

In total, data from 25 infant hips could be used in 15 consecutive infants;

in five infants, measurement was unilateral due to increasing restlessness.

The tilt angles between the transducer and pelvic sensor of conventional hip

sonography and navigated hip sonography are shown for the frontal plane

(roll angle) and axial plane (pitch angle) in Figure 2 and Table 1.

This test of variance showed significant differences for tilt in the frontal

plane (roll angle, p


TOP-Studien

67

Table 1: Relative roll and pitch angles (between

infant pelvis and transducer in the frontal and

axial planes) for measurements without navigation

(conventional) and for measurements with

navigation system (nav); boldface = significant.

Table 1 min max mean std.-deviation

pitch-angle (conventionel) -23,8° 14,2° 0,6° 9,26

roll-angle (conventionel) -12,5° 14,3° -0,9° 7,68

pitch-angle (nav) -2,8° 4,5° 0,4° 2,23

roll-angle (nav) -3,0° 3,5° 0,3° 2,15

the navigation system significantly reduces the variance of the roll and pitch

angles, i.e. the relative tilt between the infant’s pelvis and the transducer, but

also that the mean value remains unchanged by the alignment with navigation

with regard to these two tilt angles. This means that a more accurate alignment

of the transducer with respect to the pelvis is achieved by the navigation

system, while the target alignment to the original method according to Graf

remains unchanged.

Compared to established aids such as positioning aids for the baby (cradles)

and mechanical transducer guiding devices, the main advantage of the

presented system is the accurate detection of the pelvic position. An additional

strength is not only the accuracy achieved, but also the documentation

of the 3D data, which increases the safety of the method for patients and

examiners.

A limitation of this work is the small size of the collective. Therefore, although

a highly significant improvement in transducer alignment in the frontal and

axial planes could be shown, no significant effect on sonographic alpha

angle could be presented. However, there seems to be a tendency for the

alpha-angles to be reduced under a transducer alignment corresponding to

the navigation data.

Conclusion

This work shows that the alignment between pelvis and transducer can be

significantly improved by the presented navigation system. This represents

a promising approach to increase the quality of the screening program.

Further studies in a large collective are necessary to analyze the effects on

the sonographically measured hip parameters.

Priv.-Doz. Dr. Alexander Kolb

Author:

Alexander Kolb, senior physician,

head of the outpatient clinic

for femoropatellar pathologies

at the Department of Orthopaedics

and Trauma Surgery,

Medical University of Vienna.

Endocert surgeon; 2014 GOTS

fellow. Specialties: Pediatric

orthopedics, endoprosthetics,

sports orthopedics.

References:

1

Graf, R. Fundamentals of sonographic diagnosis of infant hip dysplasia. J. Pediatr. Orthop. 4,

735–740 (1984).

2

Ea, S. et al. Inter-observer agreement of ultrasonographic measurement of alpha and beta angles

and the final type classification based on the Graf method. 671–678

3

Roposch, A., Graf, R. & Wright, J. G. Determining the reliability of the Graf classification for hip

dysplasia. Clin. Orthop. Relat. Res. 447, 119–24 (2006).

4

Kolb, A. et al. Measurement considerations on examiner-dependent factors in the ultrasound

assessment of developmental dysplasia of the hip. Int. Orthop. 41, 1245–1250 (2017).

5

Kolb, A. et al. Development of an electronic navigation system for elimination of examiner-dependent

factors in the ultrasound screening for developmental dysplasia of the hip in newborns. Sci. Rep. 10,

1–5 (2020).

6

Kolb, A. Electronic Transducer Guiding Device for the Sonographic Screening for Developmental

Dysplasia of the Hip. MUW Technol. Offer. 782.18 (2019). doi:10.1007/s00264-017-3455-9


Publikationen

68

Originalarbeiten 2020

Der Impact Factor ist eine errechnete Zahl, deren Höhe den Einfluss einer wissenschaftlichen

Fachzeitschrift wiedergibt. Er gibt an, wie häufig im Durchschnitt ein in

dieser Zeitschrift veröffentlichter Artikel von anderen wissenschaftlichen Artikeln

pro Jahr zitiert wird. Die ersten 20 Prozent der Zeitschriften des Fachgebietes im

Journal Citation Reports (geordnet nach Höhe des Impact Factors) sind Top-Journale.

Die zwischen 20 und 60 Prozent liegenden Zeitschriften gelten als Standard-Journale.

Folgend sind hier die Top- und Standard-Publikationen des Jahres 2020 angeführt.

Universitätsklinik für

Orthopädie und Unfallchirurgie

Top-Publikationen 2020

Agibetov A, Seirer B, Dachs TM, Koschutnik M, Dalos D, Rettl

R, Duca F, Schrutka L, Agis H, Kain R, Auer-Grumbach M,

Binder C, Mascherbauer J, Hengstenberg C, Samwald M,

Dorffner G, Bonderman D. Machine Learning Enables Prediction

of Cardiac Amyloidosis by Routine Laboratory Parameters:

A Proof-of-Concept Study. J Clin Med. 2020 May

3;9(5):1334. (5.688)

Acem I, Verhoef C, Rueten-Budde AJ, Grünhagen DJ, van

Houdt WJ, van de Sande MAJ; PERSARC study group:

Aston W, Bonenkamp H, Desar IME, Ferguson PC, Fiocco

M, Gelderblom H, van Ginkel RJ, van der Graaf W, Griffin

AM, Haas RL, van der Hage JA, Hayes AJ, Jeys LM, Keller

J, Laitinen MK, Leithner A, Maretty-Kongstad K, Ozaki T,

Pollock R, van Praag VM, Smith MJ, Smolle MA, Styring E,

Szkandera J, Tanaka K, Tunn P-U, Willegger M, Windhager

R, Wunder JS, Zaikova O. Age-related differences of oncological

outcomes in primary extremity soft tissue sarcoma:

a multistate model including 6260 patients, Eur J Cancer.

2020 Dec;141:128-136. (7.275)

Andreou D, Ranft A, Gosheger G, Timmermann B, Ladenstein

R, Hartmann W, Bauer S, Baumhoer D, van den Berg

H, Dijkstra PDS, Dürr HR, Gelderblom H, Hardes J, Hjorth L,

Kreyer J, Kruseova J, Leithner A, Scobioala S, Streitbürger

A, Tunn PU, Wardelmann E, Windhager R, Jürgens H, Dirksen

U; GPOH-Euro-EWING99 consortium. Which Factors

Are Associated with Local Control and Survival of Patients

with Localized Pelvic Ewing‘s Sarcoma? A Retrospective

Analysis of Data from the Euro-EWING99 Trial. Clin Orthop

Relat Res. 2020 Feb;478(2):290-302. doi: 10.1097/

CORR.0000000000000962. (4.154)

Apprich SR, Schreiner MM, Szomolanyi P, Welsch GH, Koller

UK, Weber M, Windhager R, Trattnig S. Potential predictive

value of axial T2 mapping at 3 Tesla MRI in patients with untreated

patellar cartilage defects over a mean follow-up of

four years. Osteoarthritis Cartilage. Osteoarthritis Cartilage.

2020 Feb;28(2):215-222 (4.879)

Benca E, Listabarth S, Flock FKJ, Pablik E, Fischer C, Walzer

SM, Dorotka R, Windhager R, Ziai P. Analysis of Running-Related

Injuries: The Vienna Study. J Clin Med. 2020

Feb 6;9(2):438. (5.688)

Boettner F, Sculco P, Faschingbauer M, Rueckl K, Windhager

R, Kasparek MF. Clinical outcome of posterior-stabilized

total knee arthroplasty using an increased flexion gap

in patients with preoperative stiffness. Bone Joint J. 2020

Apr;102-B(4):426-433. (4.301)

Boettner F, Springer B, Windhager R, Waldstein W. The tibial

spine sign does not indicate cartilage damage in the central

area of the distal lateral femoral condyle. Knee Surg Sports

Traumatol Arthrosc. 2020 Aug;28(8):2592-2597. (3.166)

Böhler C, Weimann P, Alasti F, Smolen JS, Windhager R,

Aletaha D. Rheumatoid arthritis disease activity and the risk

of aseptic arthroplasty loosening. Semin Arthritis Rheum.

2020 Apr;50(2):245-251 (5.072)

Breuer R, Fiala R, Schrenk N, Tiefenboeck TM. Prospective

Short-Term and Return-to-Sports Results of a Novel Uncemented

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Anchorage. J Clin Med. 2020 Jun 24;9(6):1972. (5.688)

Buchtele N, Herkner H, Schörgenhofer C, Merrelaar A, Laggner

R, Gelbenegger G, Spiel AO, Domanovits H, Lang I, Jilma

B, Schwameis M. High Platelet Reactivity after Transition

from Cangrelor to Ticagrelor in Hypothermic Cardiac Arrest

Survivors with ST-Segment Elevation Myocardial Infarction.

J Clin Med. 2020 Feb 21;9(2):583 (5.688)


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69

Bumberger A, Koller U, Hofbauer M, Tiefenboeck TM, Hajdu

S, Windhager R, Waldstein W. Ramp lesions are frequently

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2020 Mar;28(3):840-854 (3.170)

Chiari C, Grgurevic L, Bordukalo-Niksic T, Oppermann H, Valentinitsch

A, Nemecek E, Staats K, Schreiner M, Trost C, Kolb

A, Kainberger F, Pehar S, Milosevic M, Martinovic S, Peric M,

Sampath TK, Vukicevic S, Recombinant Human BMP6 Applied

Within Autologous Blood Coagulum Accelerates Bone Healing:

Randomized Controlled Trial in High Tibial Osteotomy Patients.

J Bone Miner Res. 2020 Oct;35(10):1893-1903 (5.854)

Carlson BB, Salzmann SN, Shirahata T, Ortiz Miller C, Carrino

JA, Yang J, Reisener MJ, Sama AA, Cammisa FP, Girardi

FP, Hughes AP. Prevalence of osteoporosis and osteopenia

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fusion patients. Neurosurg Focus. 2020 Aug;49(2):E5 (3.642)

Cortese, A., Zhu, Y., Rebelo, A.P. Negri S., Courel S., Abreu L.,

Bacon C, Bai Y, Bis-Brewer D, Bugiardini E, Buglo E., Danzi

MC, Feely S, Athanasiou-Fragkouli A, Haridy NA, Inherited

Neuropathy Consortium*, Isasi R, Khan A, Laurà M, Magri

S, Pipis M, Pisciotta C, Powell E, Rossor AM, Saveri P, Sow den

JE, Tozza S, Vandrovcova J, Dallman J, Grignani E, Marchioni

E, Scherer SS, Tang B, Lin Z, Al-Ajmi A, Schüle R, Synofzik

M, Maisonobe T, Stojkovic T, Au er-Grumbach M, Abdelhamed

MA, Hamed SA, Zhang R, Manganelli F, Santoro L,

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Shy ME, R. Zhai G, Zuchner S. Biallelic mutations in SORD

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with implications for diabetes. Nat Genet. 2020

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Reichel H, Boettner F. Cartilage survival of the knee strongly

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Arthrosc. 2020 May;28(5):1346-1355. (3.170)

Frenzel S, Horas K, Rak D, Boelch SP, Rudert M, Holzapfel

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van Calster B, Steyerberg EW; CENTER-TBI collaborators

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2020 Mar 20. (4.952)

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Lecky F, Klimek M, Lingsma HF; CENTER-TBI collaborators

(Antoni A, Schwendenwein E). Tracheal intubation in

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10.1016/j.bja.2020.05.067. Epub 2020 Jul 31 (6.880)

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Heisinger S, Hitzl W, Hobusch GM, Windhager R, Cotofana S.

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Pala E, Funovics PT, Groundland JS, Lozano-Calderon S,

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FJ, Letson GD, Temple HT. Nonmechanical Revision

Indications Portend Repeat Limb-Salvage Failure Following

Total Femoral Replacement. J Bone Joint Surg Am. 2020 Sep

2;102(17):1511-1520 (4.578)

Jacob L, Cogné M, Tenovuo O, Røe C, Andelic N, Majdan M,

Ranta J, Ylen P, Dawes H, Azouvi P; CENTER-TBI Participants

and Investigators (Antoni A, Schwendenwein E). Predictors

of Access to Rehabilitation in the Year Following Traumatic

Brain Injury: A European Prospective and Multicenter Study.

Neurorehabil Neural Repair. 2020 Sep;34(9):814-830. doi:

10.1177/1545968320946038. Epub 2020 Aug 7. (3.982)

Jamsher M, Ballarati C, Viganò M, Hofbauer M, Togninalli D,

Lafranchi S, de Girolamo L, Denti M. Graft Inclination Angles in

Anterior Cruciate Ligament Reconstruction Vary Depending on

Femoral Tunnel Reaming Method: Comparison Among Transtibial,

Anteromedial Portal, and Outside-In Retrograde Drilling

Techniques. Arthroscopy. 2020 Apr;36(4):1095-1102. (4.433)

Kalsi-Ryan S, Rienmueller AC, Riehm L, Chan C, Jin D, Martin

AR, Badhiwala JH, Akbar MA, Massicotte EM, Fehlings MG.

Quantitative Assessment of Gait Characteristics in Degenerative

Cervical Myelopathy: A Prospective Clinical Study. J Clin

Med. 2020 Mar 10;9(3):752 (5.688)

Kelley LM, Schlegel M, Hecker-Nolting S, Kevric M, Haller B,

Rössig C, Reichardt P, Kager L, Kühne T, Gosheger G, Windhager

R, Specht K, Rechl H, Tunn PU, Baumhoer D, Wirth T,

Werner M, von Kalle T, Nathrath M, Burdach S, Bielack S, von

Lüttichau I. Pathological Fracture and Prognosis of High-Grade

Osteosarcoma of the Extremities: An Analysis of 2,847

Consecutive Cooperative Osteosarcoma Study Group (COSS)

Patients. J Clin Oncol. 2020 Mar 10;38(8):823-833 (28.349)

Koller U, Springer B, Rentenberger C, Szomolanyi P, Waldstein

W, Windhager R, Trattnig S, Apprich S. Radiofrequency

Chondroplasty May Not Have A Long-Lasting Effect in the

Treatment of Concomitant Grade II Patellar Cartilage Defects

in Humans. J Clin Med. 2020 Apr 22;9(4):1202 (5.688)


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Lass R, Olischar B, Kubista B, Waldhoer T, Giurea A, Windhager

R. Total Hip Arthroplasty Using Imageless Computer-Assisted

Navigation-2-Year Follow-Up of a Prospective Randomized

Study. J Clin Med. 2020 May 27;9(6):1620 (5.688)

Negrin LL, Dedeyan M, Plesser S, Hajdu S. Impact of

Polytrauma and Acute Respiratory Distress Syndrome

on Markers of Fibrinolysis: A Prospective Pilot Study.

Front Med (Lausanne). 2020 Jun 2;7:194. doi: 10.3389/

fmed.2020.00194. eCollection 2020. (3.900)

Okano I, Salzmann SN, Jones C, Ortiz Miller C, Shirahata T,

Rentenberger C, Shue J, Carrino JA, Sama AA, Cammisa FP,

Girardi FP, Hughes AP. The impact of degenerative disc disease

on regional volumetric bone mineral density (vBMD)

measured by quantitative computed tomography. Spine J.

2020 Feb;20(2):181-190. doi:10.1016/j.spinee.2019.02.017.

Epub 2019 May 21. PMID: 31125693 (3.196)

Okano I, Ortiz Miller C, Salzmann SN, Hoshino Y, Shue J,

Sama AA, et al. Minimal Clinically Important Differences

of the Hospital for Special Surgery Dysphagia and Dysphonia

Inventory and Other Dysphagia Measurements in

Patients Undergoing ACDF. Clin Orthop Relat Res. 2020

Oct;478(10):2309-2320 (4.329)

Raudner M, Schreiner MM, Hilbert T, Kober T, Weber M,

Szelényi A, Windhager R, Juras V, Trattnig S. Clinical implementation

of accelerated T 2 mapping: Quantitative magnetic

resonance imaging as a biomarker for annular tear

and lumbar disc herniation. Eur Radiol. 2020 Dec 3 (4.101)

Raudner M, Schreiner M, Hilbert T, Kober T, Weber M, Windhager

R, Trattnig S, Juras V. Accelerated T2 Mapping of the

Lumbar Intervertebral Disc: Highly Undersampled K-Space

Data for Robust T2 Relaxation Time Measurement in Clinically

Feasible Acquisition Times. Invest Radiol. 2020

Nov;55(11):695-701 (5.156)

Rienmüller A, Maffiuletti NA, Schwyzer HK, Eggspühler A.

Shoulder Muscle Strength and Neuromuscular Activation 2

Years after Reverse Shoulder Prosthesis-An Experimental

Case Control Study. J Clin Med. 2020 Jan 29;9(2):365 (5.688)

Rothbauer M, Höll G, Eilenberger C, Kratz SRA, Farooq B,

Schuller P, Olmos Calvo I, Byrne RA, Meyer B, Niederreiter B,

Küpcü S, Sevelda F, Holinka J, Hayden O, Tedde SF, Kiener HP,

Ertl P. Monitoring tissue-level remodelling during inflammatory

arthritis using a three-dimensional synovium-on-a-chip

with non-invasive light scattering biosensing. Lab Chip. 2020

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Rothbauer M, Eilenberger C, Spitz S, Bachmann B, Pajenda

J, Schwaighofer A, Höll G, Helmke PS, Kohl Y, Lendl B, Ertl P.

“FTIR spectroscopy as a novel analytical approach for investigation

of glucose transport and glucose transport inhibition

studies in transwell in vitro barrier models”,Spectrochimica

Acta Part A: Molecular and Biomolecular Spectroscopy, 2020

Aug 15;237:118388 (3.232)

Salzmann SN, Okano I, Ortiz Miller C, Chiapparelli E, Reisener

M-J, Winter F, et al. Regional bone mineral density differences

measured by quantitative computed tomography in

patients undergoing anterior cervical spine surgery. Spine J

2020 Jul;20(7):1056-1064 (3.191)

Schieder S, Nemecek E, Schuh R, Kolb A, Windhager R,

Willegger M. Radiographic Sagittal Tibio-Talar Offset in Ankle

Arthrodesis-Accuracy and Reliability of Measurements.

J Clin Med. 2020 Mar 16;9(3):801 (5.688)

Schinhan M, Toegel S, Weinmann D, Schneider E, Chiari C,

Gruber M, Nehrer S, Windhager R. Biological Regeneration

of Articular Cartilage in an Early Stage of Compartmentalized

Osteoarthritis: 12-Month Results. Am J Sports Med.

2020 May;48(6):1338-1346 (6.093)

Schneider E, Stamm T, Schinhan M, Peloschek P, Wind hager

R, Chiari C. Total Hip Arthroplasty after Previous Chiari Pelvic

Osteotomy-A Retrospective Study of 301 Dysplastic Hips. J

Arthroplasty. 2020 Dec;35(12):3638-3643 (3.709)

Schreiner MM, Raudner M, Marlovits S, Bohndorf K, Weber

M, Zalaudek M, Röhrich S, Szomolanyi P, Filardo G,

Windhager R, Trattnig S. The MOCART (Magnetic Resonance

Observation of Cartilage Repair Tissue) 2.0 Knee Score

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Vande Vyvere T, De La Rosa E, Wilms G, Nieboer D, Steyerberg

E, Maas AIR, Verheyden J, van den Hauwe L, Parizel

PM; CENTER-TBI Participants and Investigators (Antoni

A, Schwendenwein E). Prognostic Validation of the NINDS

Common Data Elements for the Radiologic Reporting of

Acute Traumatic Brain Injuries: A CENTER-TBI Study. J

Neurotrauma. 2020 Jun 1;37(11):1269-1282. doi: 10.1089/

neu.2019.6710. Epub 2020 Feb 25. (4.056)

Voormolen DC, Polinder S, von Steinbuechel N, Feng Y, Wilson

L, Oppe M, Haagsma JA; CENTER-TBI participants and

investigators (Antoni A, Schwendenwein E). Health-related

quality of life after traumatic brain injury: deriving value

sets for the QOLIBRI-OS for Italy, The Netherlands and The

United Kingdom. Qual Life Res. 2020 Nov;29(11):3095-

3107. doi: 10.1007/s11136-020-02583-6. Epub 2020 Jul 15.

(2.773)

Vukicevic S, Grgurevic L, Erjavec I, Pecin M, Bordukalo-

Niksic T, Stokovic N, Lipar M, Capak H, Maticic D, Windhager

R, Sampath TK, Gupta M. Autologous blood coagulum is a

physiological carrier for BMP6 to induce new bone formation

and promote posterolateral lumbar spine fusion in rabbits. J

Tissue Eng Regen Med. 2020 Jan;14(1):147-159. doi: 10.1002/

term.2981 (3.319)

Weihs V, Heel V, Dedeyan M, Lang NW, Frenzel S, Hajdu S,

Heinz T, Age and traumatic brain injury as prognostic factors

for late-phase mortality in patients defined as polytrauma

according to the New Berlin Definition: experiences

from a level I trauma center. Arch Orthop Trauma Surg. 2020

Oct 17 (2.021)

Willegger M, Benca E, Hirtler L, Moser L, Zandieh S, Windhager

R, Schuh R. Peroneus brevis as source of instability

in Jones fracture fixation. Int Orthop. 2020 Jul;44(7):1409-

1416 (2.854)

Willegger M, Seyidova N, Schuh R, Windhager R, Hirtler

L. The tibialis posterior tendon footprint: an anatomical

dissection study. J Foot Ankle Res. 2020 May 19;13(1):25

(1.604)

Wilson N, Hurkmans E, Adams J, Bakkers M, Balažova P,

Baxter M, Blavnsfeldt AB, Briot K, Chiari C, Cooper C, Dragoi

R, Gabler G, Lems W, Mosor E, Pais S, Simon C, Studenic

P, Winter F, Okano I, Salzmann SN, Rentenberger C, Shue

J, Sama AA, et al. A Novel and Reproducible Classification

of the Vertebral Artery in the Subaxial Cervical Spine. Oper

Neurosurg (Hagerstown). 2020 Jun 1;18(6):676-683 (1.470)

Zak L, Tiefenboeck TM, Wozasek GE, Intramedullary Bone

Lengthening Following Preceding Hip Surgery-A Case Series.

J Clin Med. 2020 Dec 19;9(12):4104. (3.303)

Supplement/Abstract

Beitzke D, Gremmel F, Senn D, Laggner R, Kammerlander

A, Wielandner A, Nolz R, Hülsmann M, Loewe C. Effects of

Levosimendan on cardiac function, size and strain in heart

failure patients. Int J Cardiovasc Imaging. 2020 Oct 24.

doi: 10.1007/s10554-020-02077-z. Online ahead of print.

(1,970)

Breitenbach J, Fischer A, von Dalwigk K, Sevelda F, Goldhahn

K, Galardon E, Toegel S, Steiner G, Klosch B. Resveratrol

Derivatives for the Treatment of Inflammatory and

Degenerative Joint Diseases. Effects on Fibroblast-Like

Synoviocytes and Chondrocytes. Abstracts / Osteoarthritis

and Cartilage 28 (2020) S86eS527

Hayer S, Niederreiter B, Windhager R, Aletaha D, Gabius HJ,

Toegel S. Distinct Galectin Profile in inflammation-mediated

cartilage damage. Abstracts/ Osteoarthritis and Cartilage

28 (2020) S86eS527

Hilmarsen HT, Fernandes Rosenegger P, Holla OL, Reiter SBCF,

Strand L, Braathen GJ, Senderek J, Hoyer H, Auer-Grumbach

M. Allele dropout caused by an AT-repeat in MME. European

Journal of Human Genetics 28 (Suppl. 1): 956-957., 2020

Hofer C, Trost C, Panotopoulos J, Funovics TP, Windhager R,

Hobusch MG. Using means of transport and walking aids after

treatment for primary malignant bone tumors in the lower

extremity – A minimum follow-up of 20 years. EMSOS 2019

Kirchen N, Reich L, Waldstein W, Hopf T, Heller KD, Wienert

S, Krenn V [ARMD reaction patterns in knee arthroplasty : A


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novel hypothetical mechanism: hingiosis]. Orthopade. 2020

Feb;49(2):183-189. doi: 10.1007/s00132-019-03776-9

Karner M, Stihsen C, Grohs J. Die Progressionsgeschwindigkeit

der idiopathischen Adoleszentenskoliose und die Möglichkeit

der Adaptierung des Untersuchungsintervalls. Jatros

Orthopädie, Traumatologie, Rheumatologie 5/2020:43

Koller U, Springer B, Rentenberger C, Szomolanyi P, Waldstein-Wartenberg

W, Windhager R, Trattnig S, Apprich S.

Radiofrequency Chondroplasty Is Not Recommended For

The Treatment Of Concomitant Grade II Patellar Cartilage

Defects. Abstracts / Osteoarthritis and Cartilage 28 (2020)

S86eS527

Winkler S, Grohs JG. A clinical 20-years follow-up on PLIF

operation. Eurospine 2020, QF65

Feuerstein L. Winkler S, Grohs JG. Long Term Evaluation of

PLIF after 20 Years. DWG 2020, online 9.-11.12.2020, V5

Nia A: Varos-Schaftsystem - eine Pilotstudie für den klinischen

Einsatz in der Frühphase der Rehabilitation, A. Nia,

S.Domayer, OTWorld 2020

Rothbauer M, Schobesberger S, Byrne R, Kiener HP, Toegel S,

Ertl P. A human joint-on-a-chip as alternative to animal models

in osteoarthritis. OARSI Abstracts Volume 28, Supplemant

1, S89, APRIL 01, 2020

Schinhan M, Toegel S, Weinmann D, Schneider E, Chiari C,

Gruber M, Nehrer S, Windhager R. Biological Regeneration

In A Compartmentalized Early Stage Of Osteoarthritis:

12-Month Results Of A Randomized Trial In Sheep. Abstracts

/ Osteoarthritis and Cartilage 28 (2020) S86eS527

Steinecker-Frohnwieser B, Kullich W, Kratschmann C, Cezanne

M, Toegel S, Weigl L. Activation of the Mechanosensitive

Ion Channel Piezo1/2 by Yoda1 Modulates Cellular Functions

of Human Oa Chondrocytes. Abstracts / Osteoarthritis and

Cartilage 28 (2020) S86eS527

Toegel S, Führer J, Pichler KM, Gabius HJ, Kubista B, Martelanz

L, Windhager R, Altmann F. Glycophenotyping of Osteoarthritic

Fibroblast-Like Synoviocytes. Abstracts / Osteoarthritis

and Cartilage 28 (2020) S86eS527

Toegel S, Pichler KM, Weinmann D, Fiebrich J, Kenn M,

Schreiner W, Lass R, Windhager R, Gabius HJ. Galectin-4

Triggers Disease Markers In Osteoarthritic Chondrocytes

Via Nf-Kappa B. Abstracts / Osteoarthritis and Cartilage 28

(2020) S86eS527

Sonstige Publikationen und Substandard

Antoni A, Trautinger F, Heinz T, Hajdu S. Hemiarthroplasty in

a patient with femoral neck fracture and pyoderma gangrenosum:

a case report and review of the literature. J Med Case

Rep. 2020 Jan 14;14(1):8. doi: 10.1186/s13256-019-2329-8

Beck-Tölly A, Eder M, Beitzke D, Eskandary F, Agibetov A,

Lampichler K, Hamböck M, Regele H, Kläger J, Nackenhorst

M, Böhmig GA. Magnetic Resonance Imaging for Evaluation

of Interstitial Fibrosis in Kidney Allografts. Transplant Direct.

2020 Jul 15;6(8)

Benca E, Dlaska C, Di Franco M, Hobusch G, Windhager R,

Angeli T, von Skrbensky T. Biomechanical comparison of

knotless vs. knotted suture anchors in the acetabular rim

with respect to bone density. Clin Biomech (Bristol, Avon).

2020 Apr;74:21-26. (1,977)

Benca E, Amini, M, Pahr DH. Effect of CT imaging on the accuracy

of the finite element modelling in bone. Eur Radiol Exp

4, 51 (2020)

Boettner F, Bechler U, Springer B, Faschingbauer M, Jungwirth-Weinberger

A. Impaction Bone Grafting in Revision

Total Knee Arthroplasty-Using Mesh and Cone to Contain

the Defect: A Report of 3 Cases. Arthroplast Today. 2020 Aug

10;6(3):578-584. doi: 10.1016/j.artd.2020.07.001

Bonderman D, Pölzl G, Ablasser K, Agis H, Aschauer S, Auer-Grumbach

M, Binder C, Dörler J, Duca F, Ebner C, Hacker

M, Kain R, Kammerlander A, Koschutnik M, Kroiss AS, Mayr

A, Nitsche C, Rainer PP, Reiter-Malmqvist S, Schneider M,

Schwarz R, Verheyen N, Weber T, Zaruba MM, Badr Eslam R,

Hülsmann M, Mascherbauer J. Diagnosis and treatment of

cardiac amyloidosis: an interdisciplinary consensus statement.

Wien Klin Wochenschr. 2020 Dec;132(23-24):742-761

Chiari C. Wachstumsschmerzen von Kindern: Immer mit Ausschlussdiagnose

arbeiten. SCHMERZ NACHRICHTEN Nr. 4 |

Dezember 2020

Chiari C. Interview, Mesenchymale Stammzellen | Knochendefekte

| Im Blickpunkt | Orthopädie & Rheuma, Ausgabe

1/2020

Döring K, Puchner S, MTP-I-Arthrodese – Komplikationen-

MTP-I-Arthrodesis – Complications. FussSprungg 18 (2020),

287-294

Eilenberger Ch, Selinger F, Rothbauer M, Lin Y, Limbeck A,

Schädl B, Grillari J, Kavok NS, Klochkov VK, MalyukinYV,

Margitich V, Ert P. „Cytotoxicity, Retention, and Anti-inflammatory

Effects of a CeO2 Nanoparticle-Based Supramolecular

Complex in a 3D Liver Cell Culture Model”, ACS

Pharmacology & Translational Science, DOI: https://doi.

org/10.1021/acsptsci.0c00170 New Journal no JCR index

Giurea A. Kolumne in: Sport in Wien, Echo Verlag Wien. Kolumne

in: Running, Echo Verlag Wien

Gregori M, Zott S, Hajdu S, Braunsteiner T. Response to Kholinne

et al regarding: „Preserving the radial head in comminuted

Mason type III fractures without fixation to the radial

shaft: a mid-term clinical and radiographic follow-up study“.

J Shoulder Elbow Surg. 2020 Sep;29(9):e359-e360. doi:

10.1016/j.jse.2020.04.043. Epub 2020 Jun 9

Greistorfer S, Suppan J, Cyran N, Klepal W, Farkas R, Rudoll

L, von Byern J. Characterization of the Anion vulgaris pedal

gland system. Journal of Morphology. 10.1002/jmor.21231

(1,560)

Heisinger S, Aspalter S, Grohs JG. Regarding „Radiation

Exposure in Posterior Lumbar Fusion: A Comparison of CT

Image-Guided Navigation, Robotic Assistance, and Intraoperative

Fluoroscopy” by Wang et al, Letter to the Editor, Global

Spine Journal, 10 issue: 8, page(s): 1084-1085

Hohenberger G, Dreu M, Kreurthaler H, Gruber G, Ried R,

Schwarz A, Vielgut I, Widhalm HK, Sadoghi P. Patellar Tendon

Length is Associated with Lower Extremity Length but Not

Gender Indian Journal of Orthopaedics. 10.1007/s43465-

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Holzer G, Kokešová H. [Adolf Lorenz und Tomáš Garrigue Masaryk-an

extraordinary encounter]. Wien Med Wochenschr.

2020 Jun;170(9-10):238-245.

Krestan C, Greitbauer M. Trauma to the thoracic spine and

chest. Der Radiologe. 10.1007/s00117-020-00712-3 (0,460)

Negrin LL. Perioperatives Management des Polytraumas. Jatros

Orthopädie & Traumatologie Rheumatologie 6/2020

Noebauer-Huhmann IM, Chaudhary SR, Papakonstantinou

O, Panotopoulos J, Weber MA, Lalam RK, Albtoush OM, Fueger

BJ, Szomolanyi P, Grieser T, Bloem. Soft Tissue Sarcoma

Follow-up Imaging: Strategies to Distinguish Post-treatment

Changes from Recurrence.JL.Semin Musculoskelet

Radiol. 2020 Dec;24(6):627-644. doi: 10.1055/s-0040-

1721464. Epub 2020 Dec 11.PMID: 33307581

Nürnberger S, Wiener Editorial, Sylvia Nurnberger is Researcher

of the Month December 2020 Klinische Wochenschrift

2020, 132 (23-24), S.: 801

Okano I, Salzmann SN, Ortiz Miller C, Rentenberger C,

Schadler P, Sax OC, Shue J, Sama AA, Cammisa FP, Girardi FP,

Hughes AP. Correlation between Urine N-Terminal Telopeptide

and Fourier Transform Infrared Spectroscopy Parameters: A

Preliminary Study J Osteoporos. 2020 Feb 11;2020:5725086.

doi: 10.1155/2020/5725086. eCollection 2020

Payr S. Perioperatives Management in der Kindertraumatologie.

Jatros Orthopädie & Traumatologie Rheumatologie

Payr S. Thorakolumbale Frakturen: eine Herausforderung bei

älteren Patienten. Jatros Orthopädie & Traumatologie Rheumatologie

Rentenberger C, Okano I, Salzmann SN, Shirahata T, Reisener

MJ, Shue J, Sama AA, Cammisa FP, Girardi FP, Hughes AP.

Determinants of Postoperative Spinal Height Change among

Adult Spinal Deformity Patients with Long Construct Circumferential

Fusion. Asian Spine J. 2020 Sep 3. doi: 10.31616/

asj.2020.0010. Online ahead of print. PMID: 32872760

Rentenberger C, Okano I, Salzmann SN, Winter F, Plais N,

Burkhard MD, Shue J, Sama AA, Cammisa FP, Girardi FP,

Hughes AP. World Neurosurg. Perioperative Risk Factors

for Early Revisions in Stand-Alone Lateral Lumbar Interbody

Fusion. 2020 Feb;134:e657-e663. doi: 10.1016/j.

wneu.2019.10.164. Epub 2019 Nov 4. PMID: 31698117

Richter K, Chiari C. Epiphyseolysis capitis femoris (ECF),

Sports.Orthop. Traumatol. 36. 296-299 (2020).

Rothbauer M, Schuller P, Afkhami R, Wanzenboeck HD, Ertl

P, Zirath H. Microfluidic microarray for single-cell analysis.

e & i Elektrotechnik und Informationstechnik volume 137,

pages108–112(2020).

Salzmann SN, Okano I, Shue J, Hughes AP. Disabling Pruritus

in a Patient With Cervical Stenosis. J Am Acad Orthop Surg

Glob Res Rev 2020 Mar 9;4(3):e19.00178.

Schwarz-Nemec U, Friedrich KM, Prayer D, Trattnig S,

Schwarz FK, Weber M, Bettelheim D, Grohs JG, Nemec SF.

Lumbar Intervertebral Disc Degeneration as a Common Incidental

Finding in Young Pregnant Women as Observed on

Prenatal Magnetic Resonance Imaging. J Womens Health

(Larchmt). 2020 Jan 14. doi: 10.1089/jwh.2019.7964. [Epub

ahead of print]

Schwarz-Nemec U, Friedrich KM, Arnoldner MA, Schwarz FK,

Weber M, Trattnig S, Grohs JG, Nemec SF. When an incidental

MRI finding becomes a clinical issue: Posterior lumbar subcutaneous

edema in degenerative, inflammatory, and infectious

conditions of the lumbar spine. Wien Klin Wochenschr.

2020 Jan;132(1-2):27-34. doi: 10.1007/s00508-019-01576-x

Sigmund IK, Windhager R. Management der intraoperativen

Diagnostik bei periprothetischen Gelenksinfektionen. JAT-

ROS, Orthopädie & Traumatologie Rheumatologie 6 / 2020

Simon S, Resch H. Treatment of hypophosphatasia. Wiener

Medizinische Wochenschrift volume 170, pages 112–

115(2020)

Staals EL, Sambri A, Campanacci DA, Muratori F, Leithner A,

Gilg MM, Gortzak Y, Van De Sande M, Dierselhuis E, Mascard

E, Windhager R, Funovics P, Schinhan M, Vyrva O, Sys G,

Bolshakov N, Aston W, Gikas P, Schubert T, Jeys L, Abudu A,

Manfrini M, Donati DM. Expandable distal femur megaprosthesis:

A European Musculoskeletal Oncology Society study

on 299 cases. J Surg Oncol. 2020 Jun 7

Starlinger J, Balls-Berry J, Amadio PC. RE: Aliuskevicius M,

Ostgaard SE, Hauge EM, et al. 2019. Influence of ibuprofen

on bone healing after Colles‘ fracture: A randomized controlled

clinical trial. J Orthop Res. 2020 Jun;38(6):1204-

1205. doi: 10.1002/jor.24582. Epub 2020 Jan 9. (2,730)

Toegel S, Benca E, Negrin L, Windhager R. Neustrukturierung

der Forschungslandschaft im neuen Fach Orthopädie und

Traumatologie am Beispiel einer Universitätsklinik. Jatros

Orthpädie & Traumatologie, Rheumatologie

Willegger M, Schuh R. Arthroscopically Assisted Tape Augmentation

for Anterior Talofibular Ligament Repair. Arthrosc

Tech. 2020 May 14;9(6):e809-e816. doi: 10.1016/j.

eats.2020.02.017. eCollection 2020 Jun.

Willegger M, Schuh R, Trnka HJ. Komplikationen chirurgischer

Eingriffe an den Kleinzehen. FussSprungg (2020),

https://doi.org/10.1016/j.fuspru.2020.06.002

Willegger M, Schuh R. Komplikationen der Tarsometatarsale

I Arthrodese (modifizierte Lapidus Arthrodese). FussSprungg

(2020), https://doi.org/10.1016/j.fuspru.2020.08.005

Winter F, Okano I, Salzmann SN, Rentenberger C, Shue J,

Sama AA, Girardi FP, Cammisa FP, Hughes AP. A Novel and

Reproducible Classification of the Vertebral Artery in the

Subaxial Cervical Spine Oper Neurosurg (Hagerstown). 2020

Jun 1;18(6):676-683. doi: 10.1093/ons/opz310.

Windhager R, Hobusch GM. The role of surgery in soft tissue

sarcoma: Can we improve outcome and function towards

sporting activities? March 2020. memo - Magazine of European

Medical Oncology 13(1)

Wozasek GE: Mythos und Tatsachen der Knochenverlängerung.

Jatros Orthopädie & Traumatologie Rheumatologie

06/2020

Buchbeiträge

Benca E. Das instabile Sprunggelenk richtig stabilisieren.

In R. Windhager. Kompendium Forschung & Klinik 2019. (S.

22–24). Wien: Unlimited Media

Grohs, Kainberger. Rückenbeschwerden. In Klinisches und


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ritisches Denken. Manual klinischer Symptome, Syndrome

und anderer Anlassfälle inklusive e-Learning-Plattform.

Franz Kainberger, Georgios Karanikas, Gerit Schernthaner,

Thomas Szekeres. ISBN: 978-3-7089-2071-9; 1. Auflage

2020; 185-8

Trattnig S, Welsch GH, Röhrich S, Schreiner MM, Zalaudek M,

Magnetic resonance imaging of the ultrastructural composition

of articular cartilage in disease and repair - Articular

Cartilage of the Knee: Health, Disease and Therapy. 1 January

2020, Pages 343-369

Rothbauer M, Ertl P. (2020) Emerging Biosensor Trends in

Organ-on-a-Chip. In: Advances in Biochemical Engineering/Biotechnology.

Springer, Berlin, Heidelberg. https://doi.

org/10.1007/10_2020_129

Diplomarbeiten/Dissertationen

Chiari C, Willegger M: Karin Hebenstreit. Assessment of the

lower limb torsion in rotational MRI of children – A reliability

study

Egkher A: Wendelken Moritz. Entwicklung einer Diagnosestraße

zur Propriozeptionsmessung bei Pathologien der

unteren Extremität – traumatische Epiphysenlösungen des

Hüftkopfes bei Jugendlichen – Spätergebnisse nach Abschluss

des Wachstums. 07.04.2020

Giurea A: Franz Xaver Feichtinger. Vergleich: Navigationsdaten

und Röntgenanalyse

Giurea A: Richard Koza. Outcome von Knierevisionsprothesen

7 Jahresergebnisse

Gregori M, Aldrian S: Simek Rosemarie. Clinical und radiological

results after conservative and operative treatment of

bony Bankart lesions 24.08.2020

Gregori M, Aldrian S: Hegenbart Denise. Epidemiologie und

Behandlungsmöglichkeiten bei traumatischer hinterer

Schulterluxation 09.07.2020

Grohs J: Feuerstein Laurin. Adjacent Segment Degeneration

with Floating Fusions: A Prospective Study 2020

Grohs J: Winkler Sebastian. A long-term evaluation of patient

satisfaction after posterior lumbar interbody fusion: 20-years

follow-up 2020

Haider T, Hajdu S: Seiler und Aspang Jesse. Postoperative

blood loss in patients with femoral neck fractures treated

with hip arthroplasty – Comparison of lateral and supine positioning.

A retrospective data analysis. 05.12.2019

Haider T, Hajdu S: Fornather Christina. Retrospective evaluation

of endoprosthetic treatment in femoral neck fracture

patients with emphasis on perioperative hospitalisation and

complication rates. 07.04.2020

Halát G: Lichtnecker Bernadette. Verletzungsassoziierte

Charakteristika, Therapiealgorithmen und Komplikationspotential

bei animalischen Bissverletzungen im Erwachsenenalter

– eine retrospektive Datenanalyse.

Halát G: Dissertation: Clinical and biomechanical characteristics

of surgical repair in bony avulsions of the flexor digitorum

profundus tendon and introduction of an innovative

repair technique

Hofbauer M, Tiefenböck T: Gruber Samuel. Operative Behandlung

der symptomatischen anterioren glenohumeralen

Instabilität mittels Labral-Bridge-Technique – eine Single

Center Analyse. 03.06.2020

Lass R, Rentenberger C: Daniel Birgsteiner. Navigierte Hüftendoprothetik

– Verlaufsbeobachtung einer prospektiv randomisierten

Kontrollstudie

Lass R, Co-Betreuer: Lukas Rabitsch. 10-Jahres Untersuchung

nach zementfreier Knietotalendoprothese

Maier B, Aldrian S: Hauer Ulrike. Das akute Kompartmentsyndrom

im Kindes- und Jugendalter: Evaluation von Prädiktoren,

Risikofaktoren und Outcome. 04.06.2020

Negrin L: Moftakhar Timon. Suprakondyläre Humerusfrakturen

bei Kindern – eine retrospektive Datenanalyse.

31.10.2019

Negrin L: Zejnilovic Sara. Erhöht das Vorliegen einer Suizidabsicht

das Sterberisiko bei Polytrauma-Patienten.

10.06.2020

Negrin L: Masterabschluss Sportmedizin an der Donauuniversität

Krems

Sarahrudi K, Payr S: Plötzl Anna. Retrospektive Analyse

radiologischer Parameter von Wirbelkörperfrakturen des

thorakolumbalen Überganges an der Universitätsklinik für

Orthopädie und Unfallchirurgie, Medizinische Universität

Wien. 30.10.2019

Sarahrudi K, Hingsammer A: Voscak Simon. Clinical Outcome

of Conservative Treatment of Isolated Lateral Clavicular Fractures

- A Retrospective Data Analysis. 21.11.2019

Thalhammer G: Peyman Kheder. Ultraschall-basierte Evaluation

des Musculus pronator quadratus nach beugeseitiger

Verplattung bei distaler Radiusfraktur – Vergleich zweier

operativer Zugänge. 24.10.2019

Thalhammer G: Maria-Theresia Rattasits. Injuries of flexor

tendons in zone 2: a retrospective analysis to compare two

suture materials. 03.12.2019

Thalhammer G: Michaela Pröll. Behandlung von Kahnbeinpseudarthrosen

mittels avaskulärem Knochentransplantat

und Schraube – Retrospektive Evaluation der klinischen und

radiologischen Ergebnisse. 09.01.2020

Toegel S: Dr. Mahmoud Elshamly. PhD thesis: Intervertebral

disc degeneration: Role of galectins in its pathogenesis and

postoperative complications in its surgical treatment. PhD

defense: 27.11.2020.

Waldstein W: Pottmann Christoph.Erstellung von Lernkurven

in der präoperativen Planung der azetabulären Komponente

zur endoprothetischen Versorgung der Coxarthrose.

06.04.2020

Widhalm H: Huber Felix. Evaluation des klinischen Outcomes

von PatientInnen, die sich eine proximale Humerusfraktur

zugezogen haben – Operation vs. konservative Therapie.

05.12.2019

Zak L, Aldrian S: Vandermuntert Maxime. Vergleich pedobarometrischer

und koordinativer Ergebnisse nach konservativ

oder operativ behandelten Weber B Außenknöchelfrakturen

– eine Pilotstudie zur Untersuchung der kurzfristigen Insta-


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bilität und Sportfähigkeit – eine exploratorische prospektive

Studie. 06.07.2020

Preise

Benca E: Stefan-Schuy-Preis der Österreichischen Gesellschaft

für Biomedizinische Forschung. QCT-based finite element

prediction of pathologic fractures in proximal femora

with metastatic lesions. November 2020, online

Böhler C: Arthur Vick Preis (5.000 Euro)

Haider T: AO Trauma Fellowship

Haider T: Open Access Förderung der Österreichischen

Gesellschaft für Unfallchirurgie

Halát G: Grand Rounds Award „Docere cum Laude” Medizinische

Universtiät Wien – Grand Rounds

Humenberger M: Open-Access-Förderpreis der Österreichischen

Gesellschaft für Unfallchirurgie, 1. Platz

Moftakhar T: Emanuel-Trojan-Posterpreis der Österreichischen

Gesellschaft für Unfallchirurgie

Negrin L: Open Access Förderung der Österreichischen

Gesellschaft für Unfallchirurgie

Nia A: Österreichische Gesellschaft für Knochen und Mineralstoffwechsel

(ÖGKM) – Projektpreis 2019/20 für das Projekt:

Bone metabolism, bone microarchitecture, bone marrow

fat composition and vascular calcifications in men with and

without type- 2 diabetes mellitus and fragility fractures

Nürnberger S: Researcher of the Month Dezember 2020 der

MedUni Wien

Rienmüller A.: „Orthopaedic fellow research award best poster

prize 2020” 28.5.2020, University of Toronto, Division of

Orthopaedic Surgery.

Rothbauer M: FFG Innovationsscheck, Stabilität von Oberflächenbeschichtungen

für Zellkultur. Gesamtsumme: 12.500 €

Staats K: 3. Posterpreis Endoprothetikkongress, Berlin

Deutschland, 13.-15.02.2020, „Osseointegrative Effekte von

intermittierender Parathormongabe bei initialer Instabilität

von zementfreien Implantaten“

Toegel S (Senior and corresponding author): „Wissenschaftspreis

2020” (Science Award) of the Association for

Orthopaedic Research (AFOR) für Daniela Weinmann für die

Publikation „Galectin-8 induces functional disease markers

in human osteoarthritis and cooperates with galectins-1

and -3”.

Toegel S (Senior and corresponding author): „Wissenschaftspreis

2020” (Science Award) of the Austrian Spine

Society to Mahmoud Elshamly for publication DOI:10.1002/

jor.24351. Galectins-1 and -3 in Human Intervertebral Disc

Degeneration: Non‐Uniform Distribution Profiles and Activation

of Disease Markers Involving NF-κB by Galectin-1.

Waldstein W: - ‚Reviewer of the Year‘: Archives of Orthopaedic

and Trauma Surgery – Featured Author im Juli 2020 im Journal

‚Bone & Joint Research‘ für die Publikation: Serum cobalt

concentrations remain at low levels at a minimum of 20 years

following metal-on-metal total hip arthroplasty.

Drittmittelfinanzierte Projekte

Projektleitung: Halát G

Vorstellung einer innovativen, Ankerbasierten Rekonstruktionstechnik

in der chirurgischen Therapie der A2-Ringband

Ruptur

Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters

der Bundeshauptstadt Wien - Projektnummer 20029

Zuteilungsdatum: 04.06.2020

Laufzeit: 6 Monate bis Mai 2021

Gesamtsumme: 1.000 Euro

Projektleitung: Humenberger M

In-vivo Testung einer magnesiumbasierten, intramedullären

Spannosteosynthese im Kaninchenmodell (MgBioISOS)

Förderung der Österreichischen Gesellschaft für Unfallchirurgie

Start: 22.10.2018

Laufzeit: 30 Monate

Projektlaufzeit: 22.10.2018–01.04.2021

Gesamtfördersumme: 17.039,84 Euro

Projektleitung: Maier B

Beurteilung des Heilungsprozesses bei konservativ behandelten

distalen Radiusfrakturen sowie Identifizierung

osteoporotischer Frakturen bei postmenopausalen Frauen

mittels HrPQCT (hochauflösende periphere quantitative

Computertomographie)

Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters

der Bundeshauptstadt Wien – Projektnummer 20043

Zuteilungsdatum: 04.06.2020

Laufzeit: 18 Monate bis Juni 2022

Gesamtsumme: 2.000 Euro

Projektleitung: Negrin L

Welche Schlussfolgerungen lässt der zeitliche Verlauf von

Biomarkerspiegeln, die im Blut von Polytrauma-Patienten

erhoben werden, zu? – Eine Pilotstudie

Förderung der Österreichischen Gesellschaft für Unfallchirurgie

Start: Jänner 2019

Laufzeit: 48 Monate

Projektlaufzeit: 01.2019–12.2022

Gesamtfördersumme: 10.000 Euro

Projektleitung: Nürnberger S

Cartilage for Cartilage regeneration: Laser engraved decellularized

cartilage as biomaterial for defect treatment

FFG Bridge 1 Projekt

Bewilligung: Juni 2019

Laufzeit: 36 Monate

Projektlaufzeit: 01.10.2019–30.09.2022

Gesamtfördersumme: 317.936 Euro (UCO 40.748 Euro)

Projektleitung: Nürnberger S

Laserbasierte Methode zur Wiederbesiedelung von dezellularisierter

Knorpelmatrix (LaserScaffold) für die Knorpelregeneration

Lorenz Böhler Fonds

Bewilligung: Mai 2019

Projektlaufzeit: 01.09.2019–28.02.2021

Lauzzeit: 18 Monate

Gesamtfördersumme: 33.464 Euro

Projektleitung: Nürnberger S

Biological skin plug system – Characterization of the attachment

cement in ticks


Publikationen

79

Zuteilungsdatum: 28.04.2016

Laufzeit: bis 27.04.2021

Gesamtsumme: 351.254,40 Euro (davon MedUniWien:

196.702 Euro)

Projektleitung: Staats K

Titel: Functionalization of Nanopatterned Titanium (Ti) for

Biomedical Application (FTiBA)

Geldgeber: CEST

Zuteilungsnummer: FA737A1701

Zuteilungsdatum: 15.09.2020

Laufzeit: 15,5 Monate

Voraussichtliche Fertigstellung: 31.12.2021

Gesamtsumme: 33.696 Euro

Projektleitung: Toegel S.

Titel: Identifizierung von Galektinrezeptoren in arthrotischen

Knorpelzellen

Geldgeber: Johnson&Johnson

Zuteilungsdatum: 01.08.2019

Laufzeit: 18 Monate

Vorraussichtliche Fertigstellung des Projekts: Ende 2021

Gesamtsumme: 75.000 Euro

Projektleitung: Widhalm HK

The Clinical Relevance of micro RNAs in Mild Traumatic

Brain Injury– A Pilot Study

Thema: Micro RNA Diagnostik bei Schädelhirntrauma

Geldgeber: Bürgermeisterfonds der Stadt Wien

Zuteilungsdatum: 01.12.2015

Laufzeit in Monaten: 60 Monate

Voraussichtliche Fertigstellung des Projekts: Ende 2020

Gesamtsummer: 13.000 Euro

Projektleitung: Windhager R.

Titel: Allofit IT with HXPE in Total Hip Arthroplasty

Geldgeber: Zimmer Biomet Austria GmbH

Zuteilungsdatum: 30.05.2012

Laufzeit: 30.05.2012–31.01.2024

Vorraussichtliche Fertigstellung des Projekts: 31.01.2024

Gesamtsumme: 156.800 Euro

Projektleitung: Windhager R.

Titel: Attune Kurz-, mittel- und langfristige Haltbarkeit von

Attune primären Knie-Totalendoprothesen

Geldgeber: DePuy Synthes

Zuteilungsdatum: 15.02.2013

Laufzeit: 15.02.2013–15.12.2029

Vorraussichtliche Fertigstellung des Projekts: 15.12.2029

Gesamtsumme: 52.767 Euro

Projektleitung: Windhager R.

Titel: OSTEOproSPINE

Geldgeber: EU H2020

Zuteilungsdatum: 01.01.2018

Laufzeit: 01.01.2018–31.12.2022

Vorraussichtliche Fertigstellung des Projekts: 31.12.2022

Gesamtsumme: 740.000 Euro

Projektleitung: Windhager R.

Titel: Educational Grant

Geldgeber: Johnson&Johnson

Zuteilungsdatum: 02.05.2018

Laufzeit: 02.05.2018–31.12.2020

Vorraussichtliche Fertigstellung des Projekts: 31.12.2020

Gesamtsumme: 16.500 Euro

Projektleitung: Windhager R.

Titel: Ausbildungsstipendium/Funktionalität des Galektin-

Netzwerks in der arthrotischen Knorpeldegeneration

Geldgeber: Johnson&Johnson

Zuteilungsdatum: 01.07.2018

Laufzeit: 01.07.2018–31.12.2020

Vorraussichtliche Fertigstellung des Projekts: 31.12.2020

Gesamtsumme: 30.000 Euro

Projektleitung: Windhager R.

Titel: Lopain-Studie

Geldgeber: MESTEX

Zuteilungsdatum: 27.06.2018

Laufzeit: 27.06.2018–31.12.2020

Vorraussichtliche Fertigstellung des Projekts: 31.12.2020

Gesamtsumme: 62.000 Euro

Projektleitung: Windhager R.

Titel: ACTIS

Geldgeber: Johnson&Johnson/DePuyProducts,Inc.

Zuteilungsdatum: 01.12.2010

Laufzeit: 01.12.2010–31.12.2022

Vorraussichtliche Fertigstellung des Projekts: 31.12.2022

Gesamtsumme: 100.000 Euro

Projektleitung: Windhager R.

Titel: Reference Center Agreement

Geldgeber: Medacta

Zuteilungsdatum: 01.06.2020

Laufzeit: 01.06.2020–31.05.2022

Vorraussichtliche Fertigstellung des Projekts: 31.05.2022

Gesamtsumme: 10.000 Euro

Vorsitz bei Tagungen/Wissenschaftliche Leitung

Aldrian S: Vorsitz und Organisation. Novel Cartilage, Bone &

Joint Approaches, Austrian Cluster for Tissue Regeneration

Annual Meeting February 17th – 19th 2020 Österreich

Aldrian S: Vorsitz. Wirbelsäule und Neurologie, 56. Jahrestagung

der Österreichischen Gesellschaft für Unfallchirurgie

(ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie (ÖGOuT),

01.–03.10.2020, Salzburg, Österreich

Chiari C: Kursorganisation. Ausbildungskurs der Medizinischen

Universität Wien – Sonografie der Säuglingshüfte

nach Graf – 15.–16.Oktober 2020

Frenzel S: Vorsitz. Workshop des Jungen Forums der ÖGU

– Wirbelsäule – Wesentliche Grundlagen für AssistentInnen,

56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.-03.10.2020, Salzburg, Österreich

Frenzel S: Vorsitz. Sitzung des Jungen Forums der ÖGU,

56. Jahrestagung der Österreichischen Gesellschaft für

Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.-03.10.2020, Salzburg, Österreich

Grohs J: 21. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.

Die Säulen der Wirbelsäule, Wien 25.01.2020

Grohs J: Webinar. Die Wirbelsäulenchirurgie in der Corona-

Krise – Degenerative Wirbelsäulenerkrankungen. 07.05.2020


Publikationen

80

Humenberger M: Vorsitz. Klausursitzung der Zukunftskommission

der ÖGU, 21.–22.02.2020 Österreich

Humenberger M: Vorsitz. Grundlagen Schaftfrakturen, 1. ÖGU

& 1. ÖGOuT WEBINAR Versorgung von Schaftfrakturen –Teil 1

29. April 2020 Österreich

Humenberger M: Vorsitz. Versorgung von Schaftfrakturen

–Teil 2, 2. ÖGU & 2. ÖGOuT WEBINAR Versorgung von Schaftfrakturen

–Teil 2 19. Mai 2020 Österreich

Humenberger M: Vorsitz. Becken & Hüfte –Teil 1, 3. ÖGU & 3.

ÖGOuT WEBINAR Becken & Hüfte –Teil 1 19. Juni 2020 Österreich

Humenberger M: Vorsitz. Ellbogen und Unterarm, 69. ÖGU

Fortbildung/5. ÖGU & 5. ÖGOuT Webinar Ellbogen und Unterarm

20.–21. November 2020 Österreich

Humenberger M: Wissenschaftliche Leitung. Grundlagen

Schaftfrakturen, 1. ÖGU & 1. ÖGOuT WEBINAR Versorgung

von Schaftfrakturen – Teil 1 29. April 2020 Österreich

Humenberger M: Wissenschaftliche Leitung. Versorgung

von Schaftfrakturen –Teil 2, 2. ÖGU & 2. ÖGOuT WEBI-

NAR Versorgung von Schaftfrakturen –Teil 2 19. Mai 2020

Österreich

Kdolsky R: Vorsitz. ESTES Webinar „Proximal humerus fractures“,

28 SEP 2020

Kdolsky R: Vorsitz. ESTES Webinar „Geriatric polytrauma –

what is different?”, 23 NOV 2020

Nürnberger S: Vorsitz. Novel Cartilage, Bone & Joint

Approaches, Austrian Cluster for Tissue Regeneration Annual

Meeting February 17th – 19th 2020 Österreich

Nürnberger S: Vorsitz. Cartilage & Joints, Austrian Cluster for

Tissue Regeneration Annual Meeting February 17th – 19th

2020 Österreich

Pajenda G: Vorsitz. Postervorträge, 56. Jahrestagung der

Österreichischen Gesellschaft für Unfallchirurgie (ÖGU)

und 1. Jahrestagung der Österreichischen Gesellschaft für

Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Sigmund I: Vorsitz: SYMPOSIUM OF ORTHOPEDIC SEPTIC

REVISION 2 (Graz) 25.01.2020

Sigmund I: Vorsitz: Interactive PJI Webinar, 17.06.2020 (Austria)

Windhager R: Wissenschaftliche Leitung. Medacta Surgical

Days, 13.–16. Oktober 2020, Graz

Präsidentschaften und Funktionen bei Journalen

Antoni A: Reviewer Journal of Clinical Medicine

Antoni A: Beratendes Mitglied der ADNANI (Interdisziplinäre

Arbeitsgemeinschaft Neuromedizin)

Antoni A: Kassenprüferin der ÖGU (Österreichische Gesellschaft

für Unfallchirurgie)

Böhler C: Reviewer Bone and Joint Journal

Böhler C: Reviewer Journal of Bone Oncology

Böhler C: Reviewer BMJ Open

Böhler C: Reviewer Rheumatology Oxford Journal

Chiari C: Vizepräsidentin der Österreichischen Gesellschaft

für Orthopädie

Chiari C: Der Orthopäde, Rubrikherausgeberin CME Zertifizierte

Fortbildung

Frenzel S: Reviewer Plos ONE

Gregori M: Reviewer Archives of Orthopaedic and Trauma

Surgery

Giurea A: Guest Editor: Acta Chirurgica Austriaca

Giurea A: Wissenschaftlicher Beirat bei IATROS

Grohs J: Corresponding Member der North American Spine

Society (NASS)

Grohs J: Beirat der Österreichischen Gesellschaft für Wirbelsäulenchirurgie

Grohs J: Preiskommittee Otto Kraupp Preis 24.10.2020

Grohs J: Reviewer Wiener Klinische Wochenschrift

Grohs J: Reviewer Journal of clinical Medicine

Grohs J: Reviewer British Journal of Neurosurgery

Haider T: Reviewer Injury – International Journal of the Care

of the Injured

Haider T: Reviewer European Journal of Trauma and Emergency

Surgery

Haider T: Reviewer British Medical Journal (BMJ) Open

Holzer S: Präsidiumsmitglied der Österreichische Gesellschaft

für Musik und Medizin (ÖGfMM) Leitung der AG Musikermedizin

2020–2022

Humenberger M: Reviewer Injury – International Journal of

the Care of the Injured

Humenberger M: Reviewer Thrombosis and Haemostasis –

International Journal for Vascular Biology and Medicine

Humenberger M: Reviewer PLOS ONE

Humenberger M: Reviewer Journal of Clinical Medicine

Kdolsky R: Section chair ESTES: skeletal trauma and sports

medicine

Lang N: Reviewer Journal of Clinical Medicine

Lang N: Reviewer Scientific Reports

Lang N: Reviewer Diagnostics

Lass R: Editorial Board Austin Journal of Orthopedics &

Rheumatology

Lass R: Editorial Board World Journal of Orthopedics

Lass R: Reviewer Journal of Orthopedic Research

Lass R: Reviewer Bone & Joint Research

Lass R: Reviewer BMC Muskuloskeletal Disorders

Lass R: Reviewer Diagnostic Microbiology

Lass R: Reviewer European Journal of Clinical Microbiology

& Infectious Diseases

Lass R: Reviewer Expert Reviews

Lass R: Reviewer Journal of Functional Biomaterials

Negrin L: Editorial Board Member Journal of Trauma & Treatment

Negrin L: Editorial Board Member Journal of Clinical Trials

Negrin L: Reviewer Bioscience Reports

Negrin L: Reviewer BMC Pulmonary Medicine

Negrin L: Reviewer Journal of Orthopaedic Surgery and Research

Nürnberger S: Reviewer Acta Biomaterialia

Nürnberger S: Reviewer Ticks and Tick born deseases

Pajenda G: Reviewer Archives of Orthopaedic and Trauma

Surgery


Publikationen

81

Payr S: Reviewer Journal of Orthopedic Surgery and Research

Rothbauer M: Editor Organs-on-a-chip

Salzmann S: Reviewer Spine (Phila Pa 1976)

Salzmann S: Reviewer World Neurosurgery

Salzmann S: Reviewer Current Sports Medicine Reports

Salzmann S: Reviewer Osteoporosis International

Staats K: Journal of Arthroplasty

Staats K: Journal of Clinical Medicine

Staats K: Assistent*innenvertreter Österreichische Gesellschaft

für Orthopädie

Starlinger J: Reviewer International Orthopaedics

Starlinger J: Reviewer Scientific Reports

Stelzeneder B: Reviewer European Radiology

Thalhammer G: Reviewer Arthroscopy

Thalhammer G: Reviewer Zeitschrift für Orthopädie und Unfallchirurgie

Tiefenböck T: Reviewer Journal of Orthopedic Surgery and

Research

Tiefenböck T: Reviewer Journal of Clinical Medicine

Tiefenböck T: Reviewer Plos One

Toegel S: Reviewer Biomedicine & Pharmacotherapy

Toegel S: Reviewer Molecular Medicine Reports

Toegel S: Reviewer Cells Tissues Organs, Osteoarthritis and

Cartilage

Toegel S: Reviewer Scientific Reports

Toegel S: Referent für die Österreichische Akademie der

Wissenschaften (OeAW)

Toegel S: Referent Förderprogramm DOC

Toegel S: Gutachter für die Deutsche Forschungsgemeinschaft

(DFG)

Toegel S: Gutachter einer Dissertation für die Medizinische

Universität Wien

Toegel S: Gutachter einer Dissertation für die Universität für

Bodenkultur Wien

Waldstein W: Reviewer Archives of Orthopaedic and Trauma

Surgery

Waldstein W: Reviewer Bone and Joint Journal

Widhalm HK: Reviewer Journal of Clinical Medicine

Widhalm HK: Reviewer American Journal of Sportsmedicine

(AJSM)

Widhalm HK: Reviewer Knee Surgery Sports Traumatology

Arthroscopy (KSSTA)

Widhalm HK: Reviewer Neuosurgical Review

Widhalm HK: Reviewer Obesity Surgery

Willegger M: Reviewer International Orthopaedics, BMC

Musculoskeletal Disorders, Journal of Oncology

Willegger M: Generalsekretärin – Österreichische Gesellschaft

für Fußchirurgie

Willegger M: Genderbeauftrage – Österreichische Gesellschaft

für Orthopädie

Windhager R: Mitherausgeber von Journal of Ortopaedic

and Traumatology (SIOT)

Windhager R: Mitherausgeber der Z ORTHOP

Windhager R: Editorial Board Member, Journal of Orthopaedic

Translation

Windhager R: Mitglied des wissenschaftlichen Beirates der

Zeitschrift „Arzt + Patient“

Windhager R: Reviewer Acta Orthopedica

Windhager R: Reviewer British Journal of Surgery

Windhager R: Reviewer Clinical Orthopaedics and Related

Research

Windhager R: Reviewer Der Orthopäde

Windhager R: Reviewer EFORT Open Reviews

Windhager R: Reviewer Journal of Orthopaedic Translation

Windhager R: Reviewer Journal of Clinical Medicine

Windhager R: Reviewer Vorstandsmitglied ÖGO

Windhager R: Mitglied des Wissenschaftlichen Komitees

der ÖGO

Windhager R: Korrespondierendes Mitglied der Deutschen

Gesellschaft für Orthopädie und orthopädische Chirurgie

(DGOOC) ab Oktober 2016

Windhager R: Mitglied der AE-Akademie (Arbeitsgemeinschaft

Endoprothetik) ab 06.12.2013

Windhager R: Mitglied des Vereins zur Förderung von Wissenschaft

und Forschung in den neuen Universitätskliniken

am Allgemeines Krankenhaus der Stadt Wien

Windhager R: Mitglied des Advisory Board, Comprehensive

Cancer Center, Graz ab Juli 2014

Windhager R: Mitglied der MedUni Ethikkommission ab

01.03.2010

Windhager R: Ordentliches Mitglied der Europäischen Akademie

der Wissenschaften und Künste März, 2013

Windhager R: Ehrenmitglied: Italienische Gesellschaft für

Orthopädie und Traumatologie (SIOT)

Windhager R: Ehrendmitglied: Böhmischen Gesellschaft für

Orthopädie und Traumatologie

Wozasek GE: Reviewer Injury – International Journal of the

Care of the Injured

Wozasek GE: Fachgruppenobmann der Fachgruppe Unfallchirurgie

Wien

Besuchte Kurse und Kongresse

Aldrian S: ÖGU-Arbeitskreis Knie, 10.1.2020, AUVA, Wien

Aldrian S: Austrian Cluster for Tissue Regeneration Annual

Meeting February 17.2.–19.2.2020, Wien

Aldrian S: Austrian Knee Symposium 6.3.2020 Graz

Aldrian S: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der

Österreichischen Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Antoni A: AO Spine Principles Seminar – Intraoperative Imaging,

14. Februar 2020, Lille, Frankreich

Antoni A: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der

Österreichischen Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.-03.10.2020, Salzburg, Österreich

(online)

Antoni A: Deutscher Wirbelsäulenkongress/15. Jahrestagung

der Deutschen Wirbelsäulengesellschaft 09.12.2020

11.12.2020 (online)

Böhler C: 13. Endoprothetik Kongress Berlin. 13.02.2020

15.02.2020

Chiari C: Bernese Hip Symposium 2020 – 27.–29. Februar

2020, Bern, Schweiz

Chiari C: AGA-Jahreskongress-Online, 16.–19.9.2020

Chiari C: Virtual EFORT Congress 28.-30. October 2020 (online)


Publikationen

82

Döring K: 56. ÖGU Jahrestagung der ÖGU & 1. Jahrestagung

der ÖGOuT „Wirbelsäule“ – ONLINE. 1.–3.10.2020

Frenzel S: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich (online)

Frenzel S: AO Trauma Online Masters Course–Fragility

Fractures December 03.–04.12.2020, Davos, Switzerland

Grohs J: 21. Symposium der Österr. Ges. für Wirbelsäulenchirurgie,

Wien 25.1.2020

Halát G: Grund- und Spezielle Ausbildung zum Strahlenschutzbeauftragten.

Nuclear Engineering Seibersdorf, Österreichisches

Forschungszentrum Juni 2020

Halát G: ITS Kurs „Becken und proximaler Humerus“ Anatomisches

Institut, Graz

03.09.2020–04.09.2020

Humenberger M: Frenzel S: 56. Jahrestagung der Österreichischen

Gesellschaft für Unfallchirurgie (ÖGU) und 1. Jahrestagung

der Österreichischen Gesellschaft für Orthopädie

und Traumatologie (ÖGOuT), 01.–03.10.2020, Salzburg,

Österreich (online)

Lang N: AE Masterkurs Knie, München

Lang N: AE Masterkurs Hüfte, München

Negrin L: Swiss Pelvic & Acetabular Course, 17. Jänner 2020,

Zürich (Schweiz)

Negrin L: Swiss Pelvic & Acetabular Course, 18. Jänner 2020,

Solothurn (Schweiz)

Negrin L: Internationaler Fortbildungskongress für Sportmedizin,

8.–14. März 2020, St. Christoph

Negrin L: Notarztrefresher-Kurs (Schockraum + Pädiatrie),

8–9. Juni 2020, Natters

Negrin L: Zertifikatskurs: Anti-Doping und Dopingprävention

(Basismodul und Spezialmodule), 17–19. September

2020, Hall in Tirol

Negrin L: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.-03.10.2020, Salzburg, Österreich (online)

Negrin L: ITS Masterclass: Professionell, konstruktiv und

kreativ – Shaping the Future, 22. Oktober 2020, online

Negrin L: ÖÄK-Zertifikat Antidoping und Dopingprävention

Nürnberger S: Erste Schritte mit Webex (Distant Learning)

Nürnberger S: Der virtuelle Hörsaal mit Webex (Distant Learning)

Nürnberger S: PE-Seminar „Woran erkennt man schlechte

Forschung

Payr S: AE-Masterkurs Hüfte, München, 09.–10.10.2020

Payr S: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Rentenberger C: 56. Jahrestagung der Österreichischen

Gesellschaft für Unfallchirurgie (ÖGU) und 1. Jahrestagung

der Österreichischen Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Rothbauer M: SELECTBIO Innovations in Microfluidics conference

17–18th August 2020 in Boston MA

Rothbauer M: Annual Conference EUROoCS 2020, Uppsala,

Sweden, 8–9 July 2020

Schreiner MM: AE-Basis-Kompaktkurs „Hüft- und Knieendoprothetik“

03.–04.09.2020 Berlin

Sigmund I: OBIC (Webinar) 08.12.2020 (best paper)

Sigmund I: EBJIS (Webinar) 05.10.2020 How to build a BIU

Sigmund I: EBJIS (Webinar) 15.12.2020 Diabetic Foot Infection

Springer B: Wiener Handkurs – Basiskurs, 29.06.–03.07.2020

Staats K: Endoprothetikkongress 2020, Berlin, Deutschland,

13.–15.02.2020

Staats K: Current Concepts in Joint Replacement, (online)

08.–12.12.2020

Stelzeneder B: 10. Jan. 2020: Öffentliche Sitzung des Arbeitskreises

Knie der ÖGU

Stelzeneder B: 28. und 29. Feb. 2020: Leistungsphysiologisch-Internistisch-Pädiatrischer

Grundkurs II, Praxisseminar

(ÖÄK Diplom Sportmedizin), Wien

Stelzeneder B: 29. Feb. und 01. März 2020: Orthopädisch-Traumatologisch-Pädiatrischer

Grundkurs I (ÖÄK Diplom

Sportmedizin), Wien

Stelzeneder B: 29. April 2020: 1. ÖGU & 1. ÖGOuT Webinar

„Versorgung von Schaftfrakturen – Teil 1“

Stelzeneder B: 19. Mai 2020: 2. ÖGU & 2. ÖGOuT Webinar

„Versorgung von Schaftfrakturen – Teil 2“

Stelzeneder B: 19. Juni 2020: 3. ÖGU & 3. ÖGOuT Webinar

„Becken & Hüfte – Teil 1“

Stelzeneder B: 02. Juli 2020: 4. ÖGU & 4. ÖGOuT Webinar

„Becken & Hüfte – Teil 2“

Stelzeneder B: 01.–03. Okt. 2020: 56. ÖGU & 1. ÖGOuT Jahrestagung

2020: Wirbelsäule (Online)

Stelzeneder B: 14. Nov. 2020: Neue Leitlinie Sportkardiologie

der European Society Cardiology (ESC): Aktuelles für Ihre

tägliche Routine. D-A-CH Sportkardiologie (ÖÄK Sportmedizin

Diplom) (online)

Stelzeneder B: 20.+21.Nov. 2020: 5. ÖGU & 4. ÖGOuT Webinar

„Ellbogen und Unterarm“

Thalhammer G: 1. ÖGU & 1. ÖGOuT Webinar „Versorgung von

Schaftfrakturen – Teil 1“, am 29. April 2020

Thalhammer G: 2. ÖGU & 2. ÖGOuT Webinar „Versorgung von

Schaftfrakturen – Teil 2“, am 19. Mai 2020

Thalhammer G: ISAKOS Webinar, Difficult Elbow Problems:

Heterotopic Ossification and Calcification, held on June 5,

2020

Thalhammer G: Touching Hands Webinar: Practical Details

that Make Tendon and Nerve Transfer Successful, Saturday,

November 7, 2020

Thalhammer G: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung

der Österreichischen Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Thalhammer G: 4. ÖGU & 4. ÖGOuT Webinar „Becken & Hüfte

– Teil 2“ teilgenommen, am 25. Juni 2020

Thalhammer G: 69. ÖGU Fortbildung / 5. ÖGU & 5. ÖGOuT Webinar

„Ellbogen und Unterarm“, am 20.–21. November 2020

Thalhammer G: AO Webinar – Extra-Articular Distal Radius

Malunion and its Correction

Thalhammer G: AO Webinar – Bail-Out in Complex Distal Radial

Fractures

Thalhammer G: AO Webinar – Distal Radial Fractures - The

Good, the Bad, and the Ugly

Thalhammer G: IWAS WEBINAR, Arthroscopy in Scaphoid


Publikationen

83

fracture, Wrist Arthroscopy in scaphoid non-union, 3D Printing

Assisted Percutaneous Fixation of Scaphoid Fracture

and undisplaced non-union, 11. Dez. 2020

Tiefenböck T: ÖGU-Arbeitskreis Knie, 10.1.2020, AUVA, Wien

Tiefenböck T: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Tiefenböck T: GOTS Kongress online, 16.–18. Juni 2020

Tiefenböck T: 37. AGA-Kongress 2020 AGAnywhere – Virtual.

Global.Local 17.–19. September 2020

Weihs V: ASSH 2020 – American Society for Surgery of the

Hand Annual Meeting – San Antonio - ONLINE, October 1,

2020 - October 3, 2020

Weihs V: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich (online)

Widhalm HK: Konsensusmeeting – „Das Knie- Arbeitskreis

Knie“ der ÖGU: AUVA Wien, 10.01.2020

Widhalm HK: Zukunftskommissions-Meeting der ÖGU,

AUVA Meidling, 21.–22.02.2020

Widhalm HK: 1.ÖGU & 1.ÖGOuT Webinar: „Versorgung von

Schaftfrakturen Teil 1“, 29.04.2020

Widhalm HK: 2.ÖGU & 2.ÖGOuT Webinar: „Versorgung von

Schaftfrakturen Teil 2“, 19.05.2020

Widhalm HK: 3.ÖGU & 3.ÖGOuT Webinar: „Becken und Hüfte“,

Teil 1“, 19.06.2020

Widhalm HK: 4.ÖGU & 4.ÖGOuT Webinar: „Becken und Hüfte“,

Teil 2“, 02.07.2020

Widhalm HK: Virtuelles Jahrestreffen 2020 – DGU – Traumaregister,

11.09.2020

Widhalm HK: AGA-Jahreskongress-Online, 16.–19.09.2020

Widhalm HK: 56. Jahrestagung der Österr.Gesellschaft für

Unfallchirurgie,„Wirbelsäule “, Wien-Online, 01.–03.10.2020

Willegger M: Bernese Hip Symposium Pre-Course 2020

26. Februar 2020, Bern, Schweiz

Willegger M: Workshop Kinderfuß der D.A.F. am 13.11.2020

in Stuttgart (online)

Willegger M: Bernese Hip Symposium 2020 – 27.–29.Februar

2020, Bern, Schweiz

Willegger M: Virtual EFORT Congress 28.–30.October 2020

(online)

Willegger M: AOFAS Annual Meeting 2020 09.–12. September

– San Antonio, Texas, USA (online)

Willegger M: Kursorganisation: Ausbildungskurs der Medizinischen

Universität Wien – Sonografie der Säuglingshüfte

nach Graf – 15.–16.Oktober 2020

Zak L: ÖGU-Arbeitskreis Knie, 10.1.2020, AUVA, Wien

Zak L: Austrian Cluster for Tissue Regeneration Annual

Meeting February 17.2.–19.02.2020, Wien

Zak L: 2.ÖGU Web. „Versorgung Schaftfrakturen“, 19.05.2020

Zak L: Bonesupport Webinar – CeramentG, 28.05.2020

Zak L: 4. ÖGU Webinar „Becken & Hüfte“, 02.06.2020

Zak L: Nuvasive Webinar – Bone Transport Nail, 27.08.2020

Zak L: MSc Sportmedizin - Modul 1, 21.–26.09.2020

Zak L: EFAS Webinar - Adult Flatfoot, 23.09.2020

Zak L: GOTS Schweiz Webinar, 24.09.–25.09.2020

Zak L: 56. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österreichischen

Gesellschaft für Orthopädie und Traumatologie

(ÖGOuT), 01.-03.10.2020, Salzburg, Österreich

Zak L: MSc Sportmedizin – Modul 3, 12.–17.10.2020

Zak L: NewClip Webinar – Umstellungsosteotomien,

23.10.2020

Zak L: 69. ÖGU Webinar „Ellbogen und Unterarm“, 21.11.2020

Zak L: STORZ Webinar „Pre-Xmas Special”, 08.12.2020

Zak L: MSc Sportmedizin – Modul 3, 18.–23.01.2021

Vorträge

Aldrian S: Eingeladener Vortrag: Möglichkeit bei der Behandlung

von Knorpeldefekten, Austrian Knee Symposium – Orthopädie

und Traumatologie rund um das Kniegelenk Österreich

Benca E: Thermal effects during bone preparation for- and

during insertion of osseointegrated transfemoral implants.

General Assembly of the Austrian Chapter of the European

Society of Biomechanics. November 2020, online

Chiari C: 29.10.2020 Eingeladener Vortrag – Women in Orthoedics:

The supported surgeon – How to maximize your potential

Chiari C: 30.10.2020 Live Interview: Subject: Receive an

EFORT Award and learn from the best! and specifically ‚How

to maximize your chances and how to write your abstract‘. In

the studio with Prof Soren Overgaard.

Döring K, Puchner S, Pastl K, Scarf-Osteotomie und Hallux

valgus nach Austin, ASK THE EXPERT // Webinar Firma Surgebright

– 05. Oktober 2020

Fischer A, Toegel S: The glycobiology of OA: An update. Oral

presentation at the 9th Scientific Meeting of the Ludwig

Boltzmann Institute for Arthritis and Rehabilitation, virtual

meeting. 21.–22. September 2020.

Frenzel S: Visionen für das Fach Orthopädie und Traumatologie

aus Sicht der AssistentInnenvertreter der ÖGO und ÖGU,

56. Jahrestagung der Österr. Ges. für Unfallchirurgie (ÖGU)

und 1. Jahrestagung der Österr. Ges. für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Frenzel S: Begrüßung, Eröffnung der Sitzung und Überblick

über das vergangene Jahr, 56. Jahrestagung der Österr. Ges.

für Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österr. Ges.

für Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Gregori M: Speichenkopffrakturen, 69. ÖGU Fortbildung/

5. ÖGU & 5. ÖGOuT Webinar Ellbogen und Unterarm, 20.–21.

November 2020, Österreich

Grohs JG: Wer braucht eine aufrechte Säule? 21. Symposium

der Österr. Ges. für Wirbelsäulenchirurgie, Wien 25.01.2020

Grohs JG: Webinar: Die Wirbelsäulenchirurgie in der Corona-Krise

– Degenerative Wirbelsäulenerkrankungen.

07.05.2020

Grohs JG: Belastungsmuster in verschiedenen Sportarten.

ULG Public Health, online 12.05.2020

Grohs JG: Überlastungsschäden. ULG Public Health, online

12.5.2019

Grohs JG: 21. Symposium der Österr. Ges. für Wirbelsäulenchirurgie,

Die Säulen der Wirbelsäule, Wien 25.01.2020

Grohs JG: Wirbelsäulenbeschwerden Block21

Grohs JG: Prüfer Returnweek 16.07.2020

Grohs JG: Planungsteam OSCE 2020

Grohs JG: Planungsteam Block21 2020

Grohs JG: Planungsteam Block 25 2020


Publikationen

84

Grohs JG: Planungsteam TUT3

Grohs JG: Planungsteam TUT2

Grohs JG: Koordinator KPJ 2020

Grohs JG: Gutachter Habilitation Jöstl

Grohs JG: Prüfer PHD Halat

Hajdu S: Eingeladener Vortrag: Welcome, Austrian Cluster

for Tissue Regeneration Annual Meeting February 17th –

19th 2020 Österreich

Holzer S: Thorakale und thorakolumbale Wirbelkörperfrakturen:

die endoskopisch assistierte ventrale und dorsoventrale

Frakturversorgung, 56. Jahrestagung der Österr. Ges. für

Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österr. Ges.

für Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Humenberger M: Tibiakopffrakturen, 1. Online Fortbildung

MUW, 31. März. 2020 Österreich

Humenberger M: Grundlagen der Versorgung von Schaftfrakturen,

1. ÖGU & 1. ÖGOuT WEBINAR Versorgung von

Schaftfrakturen –Teil 1 29. April 2020 Österreich

Humenberger M: Ellenbogenluxationsfrakturen, GOTS Sportarzt

Zertifikatskurs, 31.07.2020, Österreich

Humenberger M: Bericht aus der Zukunftskommission, 56.

Jahrestagung der Österr. Ges. für Unfallchirurgie (ÖGU) und

1. Jahrestagung der Österr. Ges. für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Kdolsky R: Eingeladender Vortrag: Komplikationen der Versorgung

von Schaftfrakturen, 2. ÖGU & 2. ÖGOuT WEBINAR Versorgung

von Schaftfrakturen – Teil 2 19. Mai 2020 Österreich

Laggner R: Die Versorgung von Verletzungen am zervikothorakalen

Übergang an einem Level I Traumazentrum – eine

retrospektive Analyse, 56. Jahrestagung der Österr. Ges. für

Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österr. Ges.

für Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Lass R: Senior Mentoring-Programm der MedUniWien im

Studienjahr 2019/2020

Nürnberger S: CartiScaff, Austrian Cluster for Tissue Regeneration

Annual Meeting February 17th–19th 2020 – Highlights

of Musculoskeletal Research and Imaging Österreich

Pajenda G: Verletzungen der unteren Halswirbelsäule – Diagnostik

und Therapiealgorithmus, 56. Jahrestagung der

Österr. Ges. für Unfallchirurgie (ÖGU) und 1. Jahrestagung

der Österr. Ges. für Orthopädie und Traumatologie (ÖGOuT),

01.–03.10.2020, Salzburg, Österreich

Pajenda G: Fallpräsentation: Mein schlimmster Fall, 56.

Jahrestagung der Österr. Ges. für Unfallchirurgie (ÖGU) und

1. Jahrestagung der Österr. Ges. für Orthopädie und Traumatologie

(ÖGOuT), 01.–03.10.2020, Salzburg, Österreich

Pajenda G: Eingeladener Vortrag: Trauma und Versorgung

der unteren Halswirbelsäule, Webinar Johnson & Johnson

Institute, 03.07.2020

Rienmüller A: Functional objective assessment using the

TUG-test is a useful tool to evaluate outcome in lumbar spinal

stenosis. 20th Annual Scientific Conference of the Canadian

Spine Society, Whistler BC, Canada 26.02.–29.02.2020

Rienmüller A: Gait variability is a valid tool to characterize

severity of degenerative cervical myelopathy: a prospective

clinical study. 20th Annual Scientific Conference of the Canadian

Spine Society, Whistler BC, Canada 26.02.–29.02.2020

Rothbauer M: Eingeladender Vortrag. SELECTBIO Innovations

in Microfluidics conference 17-18th August 2020 in Boston

MA on ‚Joint-on-a-Chip as Alternative to Animal Models in

Arthritis Research‘

Rothbauer M: Plus Lucis training week for chemistry and

physics teachers (VFPC), Vienna, Austria (2020) on „Research

without animal experiments – interdisciplinary research at

the interface between chemistry, physics and biology“

Schwarz G: Quality and Readability of Online Resources

on Chronic Ankle Instability, 37. AGA-Kongress 2020 AG-

Anywhere – Virtual.Global.Local, 17.–19. September 2020

Schweiz, 17.09.2020

Staats K: Sitzung des Jungen Forums der ÖGU, 56. Jahrestagung

der Österr. Ges. für Unfallchirurgie, 01.–02.10.2020

Staats K: Vorlesung (Wahlfach): „Grundlagen der Hüft- und

Knieendoprothetik

Starlinger J: Eingeladener Vortrag: Polytraumaversorgung

in Österreich – aktuelle Konzepte und Perspektiven, BÖC

Webinar Österreich

Toegel S: The glycobiology of OA: Status quo and ongoing

research. Oral presentation at the 8th Scientific Meeting of

the Ludwig Boltzmann Institute for Arthritis and Rehabilitation,

Vienna, Austria, 17. June 2020.

Toegel S: The glyobiology of OA: Recent progress and future

perspectives. Oral presentation at the Scientific Advisory

Board Meeting, Ludwig Boltzmann Institute for Arthritis and

Rehabilitation, Vienna, Austria, 23. November 2020.

Toegel S: Basic Lecture: Osteoarthritis biology. #850.701, Vo.

Study: N790 Doctoral Programme of Applied Medical Science.

Thematic programme: Regeneration of Bones and Joints.

Toegel S: SSM 3-Projektstudie (Wahlpflichtteil). #808.008,

SK. Study: N202 Human medicine.

Toegel S: Practical Seminar, #850.320, Se. Study: N790 Doctoral

Programme of Applied Medical Science. Thematic programme:

Regeneration of Bones and Joints.

Toegel S: SSM2 - Arthrose: Von der klinischen Wissenschaft

bis zur Grundlagenforschung, # 806.087, Se. Study: N202

Human medicine.

Toegel S: Basic Lecture: Gene expression anaylsis. #850.022,

Vo. Study: N790 Doctoral Programme of Applied Medical Science.

Thematic programme: Regeneration of Bones and Joints.

Weihs V: Eingeladener Vortrag: Stress-induced cardiomyopathy:

clinical and echocardiographic features, treatment and

prognosis, 62nd Annual World Congress – ICA 2020 International

College of Angiology Back to Back Online Meeting – 52.

Jahrestagung ÖGG 2020 Österreichische Gesellschaft für

Gefäßchirurgie Österreich

Widhalm H: Erste Erfahrungen aus Österreich: Einsatz des

Allograft- Transplantates bei der Rekonstruktion des vorderen

Kreuzbandes, 37. AGA-Kongress 2020 AGAnywhere –

Virtual.Global.Local, 17.–19. September 2020, Schweiz

Willegger M: Excellent Reliability But Significant Difference

Exists Among MRI Measurement Methods For Femoral

Torsion In Paediatric Patients. Virtual EFFORT Congress

28.–30. October 2020 – Paediatric Orthopaedics / Hip

Windhager R: WP1 Phase II clinical trial „Clinical update

and protocol amendments“. Osteoprospine, 2nd Progress

Meeting, 30.–31. Januar 2020, Zagreb

Windhager R: Lecture: „Resection and Reconstruction of bone


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Publikationen

86

tumors -lessons learnt from the last 3 decades“, 21.02.2020,

Catholic University of Rome, Institute of Orthopedics, Rom

Windhager R: Moderation: Medacta Surgical Days, 13.–16.

Oktober 2020, Graz

Windhager R: Online Vortrag, „Current status of the trial (incl.

the 2nd IDSMB report) and management under COVID-related

safety measures”, 26.–27. November 2020 OSTEOproSPI-

NE, Virtual Progress Meeting.

Poster

Hayer S: Distinct galectin profile in inflammatory-mediated

cartilage damage. Poster presentation at the OARSI 2020, Vienna,

Austria

Karner M, Stihsen C, Grohs J. Die Progressionsgeschwindigkeit

der idiopathischen Adoleszentenskoliose und die

Möglichkeit der Adaptierung des Untersuchungsintervalls.

Jatros. Orthopädie & Traumatologie Rheumatologie 5 /2020

Moftakhar T: Inzidenz und Verletzungsmuster von Elektro-Scooter-assoziierten

Verletzungen nach Einführung

eines städtischen Leihprogramms in Wien – eine retrospektive

multizentrische Studie, 56. Jahrestagung der Österr.

Ges. für Unfallchirurgie (ÖGU) und 1. Jahrestagung der

Österr. Ges. für Orthopädie und Traumatologie (ÖGOuT), 01.–

03.10.2020, Salzburg, Österreich

Nia A: Varos-Schaftsystem – eine Pilotstudie für den klinischen

Einsatz in der Frühphase der Rehabilitation, OTWorld,

27.10.2020, Deutschland

Payr S: Epidemiologischer Überblick über Frakturen der Wirbelsäule

bei Kindern und Jugendlichen – Daten eines Level

1 Traumazentrums, 56. Jahrestagung der Österr. Ges. für

Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österr. Ges.

für Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Payr S: Thorakolumbale Wirbelkörperfrakturen: Eine Herausforderung

beim älteren Patienten, 56. Jahrestagung der

Österr. Ges. für Unfallchirurgie (ÖGU) und 1. Jahrestagung

der Österr. Ges. für Orthopädie und Traumatologie (ÖGOuT),

01.-03.10.2020, Salzburg, Österreich

Payr S: Wirbelsäulenverletzungen beim kindlichen und jugendlichen

Polytrauma, 56. Jahrestagung der Österr. Ges. für

Unfallchirurgie (ÖGU) und 1. Jahrestagung der Österr. Ges.

für Orthopädie und Traumatologie (ÖGOuT), 01.–03.10.2020,

Salzburg, Österreich

Rienmüller A: Function as objective assessment using the

TUG-Test is a useful tool to evaluate outcome in lumbar spinal

stenosis surgery. 28.05.2020

Rothbauer M: Organs-on-a-chip as alternative to animal models

in orthopedic musculoskeletal disease research, Annual

Conference EUROoCS 2020, Uppsala, Sweden, 8–9 July 2020

Staats K: Osseointegrative Effekte von intermittierender

Parathormongabe bei initialer Instabilität von zementfreien

Implantaten, Endoprothetikkongress 2020, Berlin, Deutschland,

13.–15.02.2020

Starlinger J: Post-intervention changes in the relative motion

between the surrounding subsynovial connective tissue (SSCT)

and tendon in the carpal tunnel, Orthopedic Research Society

Phoenix, Arizona, 08.-11.02.2020, Vereinigte Staaten (USA)

Steinecker-Frohnwieser B: Activation of the mechanosensitive

ion channel Piezo1/2 by Yoda1 modulates cellular functions

of human OA chondrocytes. Poster presentation at the

OARSI 2020, Vienna, Austria

Toegel S: Distinct galectin profile in inflammation-mediated

cartilage damage. Poster presentation at the European Workshop

for Rheumatology Research 2020, Leuven, Belgium,

13.–15.2.2020

Toegel S: Galectin-4 triggers disease markers in osteoarthritic

chondrocytes via NF-kB. Poster presentation at the OARSI

2020, Vienna, Austria

Toegel S: Glycophenotyping of osteoarthritic fibroblast-like

synoviocytes. Poster presentation at the OARSI 2020, Vienna,

Austria

Schinhan M: Biological regeneration in a compartmentalized

early stage of osteoarthritis: 12-month results of a randomized

trial in sheep. Poster presentation at the OARSI 2020,

Vienna, Austria

Fischer A: The novel H2S-releasing compound DP* reduces

inflammation in osteoarthritic chondrocytes and fibroblast-like

synoviocytes. Poster presentation at the OARSI

2020, Vienna, Austria

Weihs V: Psychokardiologische Aspekte in der akuten Phase

des Takotsubo-Syndroms (TTS): Eine Untersuchung von

TTS-Patienten hinsichtlich somatischer und depressiver

Störungen, Resilienz und Krankheitswahrnehmung, DGPPN

Kongress 2020, 26.11.–28.11.2020, ONLINE, Deutschland

Willegger M: Arthroscopic accessibility of the metatarsal

head comparing distraction and plantarflexion in a 2 portal

technique for the first metatarsophalangeal (MTP 1) joint

AOFAS Annual Meeting 2020 9.–12. September – San Antonio,

Texas, USA (online)

Willegger M: Tibial Coverage Of The Talar Dome In Different

Ankle Positions

Virtual EFFORT Congress 28.–30.October 2020 – Selected for

Best Poster Session

Willegger M: Intraoperative Glove Perforation During Implantation

Of Cephalomedullary Nails For Pertrochanteric Fracture

Fixation, Virtual EFFORT Congress 28.–30. October 2020

Gastärzte/Beobachter

Name Land Dauer

Jamal Al-Omari Jordanien 1.09.2019-

Fellow 31.03.2020

01.04.2020-

31.03.2021

Dr. Chang-Bae Kong Süd-Korea 24.02.2020-

Fellow 23.02.2021


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