2022 Spring/Summer Highlights of Hope
This is the 2022 Spring/Summer edition of Van Andel Institute's Highlights of Hope donor publication.
This is the 2022 Spring/Summer edition of Van Andel Institute's Highlights of Hope donor publication.
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HIGHLIGHTS OF<br />
HOPE<br />
SPRING/SUMMER ’22 ISSUE<br />
2 VAI welcomes six new scientists 4 New program launched in cancer research<br />
5 Rallying to the grand challenge <strong>of</strong> Parkinson’s<br />
6 VAI scientists have record-breaking year for scientific grants<br />
8 VAI scientists recognized as top <strong>of</strong> their fields 9 Research highlights<br />
10 Newest Grad School cohort illustrates growth<br />
12 A day in the life <strong>of</strong> a VAI grad student 13 Graduate School highlights<br />
14 From Afterschool Cohort to Fulbright Scholar 16 In-person field trips return<br />
17 Education highlights 18 Events 24 Event sponsors<br />
26 VAI Purple Community partners put in the time, effort & talent<br />
28 VAI Marathon Team runners back in action<br />
29 VAI Student Ambassador Program making moves<br />
30 Gifts in action: Funding new equipment to peer into cells 32 Memorials & Tributes
RESEARCH<br />
VAI welcomes six new scientists<br />
and their labs<br />
In the past year, VAI recruited six new faculty — an achievement that expands our scientific capacity and impact in Grand Rapids and<br />
beyond. These exceptional experts, each <strong>of</strong> whom leads their own lab at the Institute, bring with them a wealth <strong>of</strong> expertise at the<br />
forefront <strong>of</strong> scientific innovation and discovery.<br />
Nick Burton, Ph.D., Assistant Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Epigenetics<br />
Joined VAI from University <strong>of</strong> Cambridge<br />
Dr. Nick Burton explores how our environment,<br />
especially microbes, can impact our health and<br />
the health <strong>of</strong> our <strong>of</strong>fspring — even before they<br />
are born. His research has extensive implications<br />
for understanding how epigenetics contributes to<br />
human disease and how the environment we are<br />
exposed to today affects not only our own health,<br />
but also our children’s.<br />
“In the last decade, it has become increasingly<br />
clear that an individual’s environment and their<br />
epigenetics play a major role in determining<br />
whether or not they will go on to develop many<br />
different pathologies, ranging from diabetes to<br />
autism. We are now beginning to understand<br />
the mechanisms underlying many <strong>of</strong> these<br />
observations. At Van Andel Institute, I look<br />
forward to working alongside many world-class<br />
researchers looking to solve these mechanisms<br />
and find new ways to improve human health.”<br />
— Dr. Nick Burton<br />
Yvonne Fondufe-Mittendorf, Ph.D., Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Epigenetics<br />
Joined VAI from University <strong>of</strong> Kentucky<br />
Dr. Yvonne Fondufe-Mittendorf investigates how<br />
environmental factors, such as toxicants, impact our<br />
genetic code and contribute to cancer. Her research<br />
is illuminating powerful new insights that could<br />
influence our understanding <strong>of</strong> health and disease,<br />
providing a path forward for new strategies for<br />
cancer prevention and treatment.<br />
“Our environment has a pr<strong>of</strong>ound impact on our<br />
health, down to the molecular level. My research<br />
addresses some <strong>of</strong> today’s health challenges<br />
by developing a deeper understanding <strong>of</strong><br />
the mechanisms underpinning this critical<br />
relationship. Van Andel Institute is a global<br />
center for leading-edge epigenetics research,<br />
and I am thrilled to be part <strong>of</strong> it.”<br />
— Dr. Yvonne Fondufe-Mittendorf<br />
Stephanie Grainger, Ph.D., Assistant Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Cell Biology<br />
Joined VAI from San Diego State University<br />
Stem cells give rise to every cell type in the human<br />
body and play important roles in health and disease.<br />
Dr. Stephanie Grainger seeks to understand how<br />
these special cells develop, how they are maintained,<br />
and how they can become cancerous, with the goal<br />
<strong>of</strong> developing new strategies for combating cancer.<br />
“Traditional cancer therapies do not target<br />
the rare cells that initiate cancer growth, and<br />
instead take a brute force approach <strong>of</strong> killing<br />
any cells that are growing. This includes the<br />
cells in your intestines, skin and hair and is why<br />
chemotherapy causes side effects like an upset<br />
stomach and hair loss. These rare cells, which<br />
behave similarly to a specialized group <strong>of</strong> cells<br />
in our bodies called stem cells, are <strong>of</strong>ten able to<br />
regrow tumors once therapy is withdrawn. One<br />
<strong>of</strong> the main goals <strong>of</strong> my research group at VAI<br />
is to figure out how these rare cells talk to each<br />
other in normal and cancerous conditions. Once<br />
we figure that out, we can more effectively kill<br />
<strong>of</strong>f these cells that initiate cancer.”<br />
— Dr. Stephanie Grainger<br />
2 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Sara Nowinski, Ph.D., Assistant Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Metabolism and Nutritional<br />
Programming<br />
Joined VAI from University <strong>of</strong> Utah<br />
Dr. Sara Nowinski investigates how cells determine<br />
the amount <strong>of</strong> energy needed for everyday life<br />
and how they adjust to meet those requirements.<br />
Her research has uncovered new insights into the<br />
intricate balance between nutrient availability and<br />
cellular respiration — both critical components for<br />
maintaining health.<br />
“Mitochondria are well known for their role in<br />
energy production as the ‘powerhouses <strong>of</strong> the<br />
cell,’ but there is still so much we don’t know<br />
about how cells control and fine-tune their<br />
activity in different situations. I’m incredibly<br />
excited to join the Department <strong>of</strong> Metabolism<br />
and Nutritional Programming at VAI and<br />
look forward to the discoveries we will make<br />
together.”<br />
— Dr. Sara Nowinski<br />
Evan Worden, Ph.D., Assistant Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Structural Biology<br />
Joined VAI from Johns Hopkins University<br />
Dr. Evan Worden leverages VAI’s powerful suite <strong>of</strong><br />
cryo-electron microscopes to explore the complex<br />
molecular interactions that give rise to cancer. To<br />
date, his research has revealed novel insights into<br />
poorly understood regulatory elements in the genetic<br />
code and illuminated how aberrations in these<br />
processes can transform healthy cells into malignant<br />
ones.<br />
“Our understanding <strong>of</strong> how epigenetics<br />
contributes to cancer has exploded in the last<br />
decade. This opened the door for us to use<br />
structural biology to answer really detailed<br />
questions about how the genetic elements<br />
expressed in cancer are regulated. I’m excited to<br />
continue this work at Van Andel Institute.”<br />
— Dr. Evan Worden<br />
Qiang Zhu, Ph.D., Assistant Pr<strong>of</strong>essor<br />
Department <strong>of</strong> Neurodegenerative Science<br />
Joined VAI from University <strong>of</strong> California, San Diego<br />
Dr. Qiang Zhu investigates the genetic, epigenetic<br />
and cellular factors that lead to neurodegenerative<br />
diseases such as ALS and frontotemporal dementia.<br />
To date, his work has revealed the complex<br />
mechanisms underlying the most common genetic<br />
cause for both <strong>of</strong> these diseases — an insight that<br />
has provided novel targets for the development <strong>of</strong><br />
new therapies.<br />
“The lack <strong>of</strong> therapies that impede progression<br />
<strong>of</strong> ALS and frontotemporal dementia is a major<br />
gap in patient care. I’m heartened that my<br />
research to date has contributed to clinical<br />
exploration <strong>of</strong> potential treatments and am<br />
excited to expand my efforts at VAI. The Institute<br />
has exceptional research facilities and a highly<br />
supportive, collaborative scientific environment.<br />
I look forward to teaming up with my colleagues<br />
to achieve our shared goal — new, more effective<br />
treatments for neurodegenerative diseases.”<br />
— Dr. Qiang Zhu<br />
In 2021, VAI was ranked by Nature Index as no. 24 in the Life Sciences<br />
category out <strong>of</strong> the top 100 nongovernmental/nonpr<strong>of</strong>it organizations<br />
(up from no. 29 in 2020).<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 3
RESEARCH<br />
New program launched to develop<br />
future leaders in cancer research<br />
The scientific leaders <strong>of</strong> tomorrow are the trainees <strong>of</strong> today —<br />
and Van Andel Institute is committed to helping them achieve<br />
success and improve human health, now and in the future.<br />
As part <strong>of</strong> our dedication to this goal, we launched VAI’s Cancer<br />
Epigenetics Training Program for exceptional postdoctoral fellows.<br />
These trainee scientists have completed their Ph.D.s but are<br />
pursuing additional training before starting their own independent<br />
laboratories.<br />
Cancer epigenetics is a growing field with untold potential to impact<br />
human health. Epigenetic abnormalities are universally found<br />
across cancers and serve as major drivers for transforming healthy<br />
cells into sick ones, making epigenetic alterations promising new<br />
targets for the development <strong>of</strong> life-changing cancer treatments.<br />
The Cancer Epigenetics Training Program combines extensive<br />
pr<strong>of</strong>essional development with comprehensive, interdisciplinary<br />
research training by VAI’s internationally recognized cadre <strong>of</strong><br />
experts. Postdoctoral trainees in the program also have access<br />
to the Institute’s state-<strong>of</strong>-the-art shared scientific resources and<br />
technologies as well as opportunities to participate in established<br />
translational research programs and partnerships led by VAI<br />
investigators.<br />
“In the past few years, VAI has become a global destination for<br />
groundbreaking, collaborative cancer epigenetics research,” said<br />
VAI Chief Scientific Officer Dr. Peter A. Jones. “Postdoctoral trainees<br />
will emerge from our Cancer Epigenetics Training Program with<br />
extensive, rigorous training and a solid foundation from which to<br />
launch their independent research careers.”<br />
The program is supported by a five-year, $1.7 million grant from<br />
the National Cancer Institute <strong>of</strong> the National Institutes <strong>of</strong> Health.<br />
Jones and VAI Associate Pr<strong>of</strong>essor Dr. Scott Rothbart will lead the<br />
program in collaboration with Dr. Erica Gobrogge, program director<br />
<strong>of</strong> VAI’s Office <strong>of</strong> Postdoctoral Affairs. The program also benefits<br />
from the guidance <strong>of</strong> its advisory committee, which includes<br />
renowned scientists from across the U.S.<br />
By supporting exceptional trainees today, VAI is helping to ensure a<br />
brighter, healthier future fueled by innovation and discovery.<br />
The Cancer Epigenetics Training program is supported by a National<br />
Cancer Institute T32 training grant (no. T32CA251066). The content is<br />
solely the responsibility <strong>of</strong> VAI and does not necessarily represent the<br />
<strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health.<br />
“In the past few<br />
years, VAI has<br />
become a global<br />
destination for<br />
groundbreaking,<br />
collaborative<br />
cancer epigenetics<br />
research.”<br />
— Peter A. Jones,<br />
Ph.D., D.Sc. (hon)<br />
4 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Rallying to the<br />
grand challenge<br />
<strong>of</strong> Parkinson’s<br />
disease<br />
How do a person’s genetics impact their risk for<br />
Parkinson’s disease?<br />
That’s the question more than 500 people from around the<br />
world explored during Van Andel Institute’s annual Grand<br />
Challenges in Parkinson’s Disease scientific symposium and<br />
parallel Rallying to the Challenge meeting for people with<br />
Parkinson’s and care partners, co-hosted with the U.K.’s Cure<br />
Parkinson’s. Held virtually in October 2021, these events tackled<br />
how two specific genes — LRRK2 and GBA1 — contribute to<br />
Parkinson’s disease risk and how they may be leveraged to<br />
develop new and urgently needed treatments. Attendees<br />
heard scientific presentations from leading researchers and<br />
participated in panel discussions with advocates and people<br />
with Parkinson’s.<br />
As part <strong>of</strong> Grand Challenges in Parkinson’s Disease and Rallying to<br />
the Challenge, we recognized two scientists for their exceptional<br />
contributions to the Parkinson’s field and community. VAI<br />
presented the 2021 Jay Van Andel Award for Outstanding<br />
Achievement in Parkinson’s Disease Research to Dr. Ted Dawson,<br />
<strong>of</strong> Johns Hopkins University for his groundbreaking research<br />
into the molecular and genetic mechanisms underlying<br />
Parkinson’s disease — many <strong>of</strong> which have informed the<br />
development <strong>of</strong> potential new medications.<br />
Cure Parkinson’s and VAI presented Dr. Camille Carroll, <strong>of</strong><br />
University <strong>of</strong> Plymouth with the 2021 Tom Isaacs Award, which<br />
honors individuals who have had a significant impact on the<br />
lives <strong>of</strong> people with Parkinson’s and/or involved them in a<br />
participatory way in research. This award recognizes Carroll’s<br />
commitment to engage people with Parkinson’s in research and<br />
to foster collaboration between scientists, physicians and the<br />
Parkinson’s community.<br />
Save the date! The next Grand Challenges in Parkinson’s<br />
Disease and Rallying to the Challenge will be held Sept. 28–29,<br />
<strong>2022</strong>. Visit grandchallengesinpd.org to learn more.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 5
RESEARCH<br />
VAI scientists have recordbreaking<br />
year for scientific grants<br />
Our scientists surpassed the Institute’s<br />
all-time funding record in 2021, earning<br />
more external grants than ever before.<br />
These important awards do more than<br />
support our groundbreaking research —<br />
they are vital, objective validation <strong>of</strong> this<br />
research.<br />
In 2021, VAI scientists earned 33 new<br />
grants, totaling more than $39 million.<br />
Achieving this milestone would not have<br />
been possible without the exceptional<br />
support from VAI donors, whose generous<br />
gifts <strong>of</strong>ten fuel the early, foundational<br />
research required to attain these highly<br />
competitive grants.<br />
Many <strong>of</strong> this year’s grants will support<br />
projects that harness the collective<br />
expertise <strong>of</strong> VAI scientists and collaborators<br />
across the U.S. Here’s a snapshot.<br />
Specialized Programs <strong>of</strong> Research<br />
Excellence (SPORE) | National Cancer<br />
Institute <strong>of</strong> the National Institutes<br />
<strong>of</strong> Health<br />
This five-year grant, estimated at $12.4 million,<br />
will support nearly 20 scientists as they<br />
work to improve epigenetic therapies for<br />
cancer. The project is co-led by Coriell<br />
Institute for Medical Research’s President<br />
and CEO Dr. Jean-Pierre Issa, Van Andel<br />
Institute’s Chief Scientific Officer<br />
Dr. Peter A. Jones and Johns Hopkins<br />
University and VAI’s Dr. Stephen Baylin. 1<br />
Read more at bit.ly/vaispore<br />
Transformative Research Award | National<br />
Institutes <strong>of</strong> Health Common Fund<br />
VAI’s Dr. J. Andrew Pospisilik and Maine<br />
Medical Center Research Institute’s<br />
Dr. Joseph Nadeau earned a five-year,<br />
$9.6 million Transformative Research Award<br />
from the National Institutes <strong>of</strong> Health<br />
to answer a set <strong>of</strong> questions that could<br />
fundamentally transform our understanding<br />
<strong>of</strong> health and disease: If you were born<br />
multiple times under the exact same<br />
circumstances, would you turn out to be the<br />
same person each time? And if not, what<br />
implications could the differences have for<br />
your health? Although they may sound like<br />
science fiction, the answers could provide<br />
real-world insights into new strategies for<br />
combating cancer, obesity and a host <strong>of</strong><br />
other health concerns and diseases. 2<br />
Read more at bit.ly/vaitransform<br />
6 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE<br />
VAI GRADUATE SCHOOL STUDENT SVETLANA DJIRACKOR
Collaborative Research Network grants |<br />
Aligning Science Across Parkinson’s<br />
Two VAI scientists and their collaborators<br />
were awarded more than $15 million to<br />
advance Parkinson’s disease research<br />
and accelerate the development <strong>of</strong> new<br />
therapies.<br />
This pair <strong>of</strong> awards, called Collaborative<br />
Research Network grants, comes from<br />
Aligning Science Across Parkinson’s, a<br />
coordinated research initiative to accelerate<br />
the pace <strong>of</strong> discovery and inform the<br />
path to a cure for Parkinson’s through<br />
collaboration, research-enabling resources<br />
and data sharing.<br />
VAI’s Dr. Michael Henderson and colleagues<br />
at Yale University and University <strong>of</strong><br />
Pennsylvania were awarded $9 million to<br />
identify areas and cell types in the brain<br />
that may be particularly vulnerable to<br />
Parkinson’s disease. 3<br />
VAI’s Dr. Hong-yuan Chu and colleagues at<br />
Emory University were awarded $6.3 million<br />
to investigate the brain’s motor cortex —<br />
which helps manage movement — and its<br />
role in Parkinson’s. Changes to the cells<br />
that comprise this critical brain region have<br />
long been implicated in the disease. They<br />
also will collaborate with scientists at SUNY<br />
Downstate and Inscopix. 4<br />
Read more at bit.ly/ASAPChu and bit.ly/<br />
ASAPHend<br />
Maximizing Investigators’ Research Award<br />
| National Institute <strong>of</strong> General Medical<br />
Sciences <strong>of</strong> the National Institutes<br />
<strong>of</strong> Health<br />
Maximizing Investigators’ Research Awards<br />
are highly competitive and prestigious fiveyear<br />
grants and, in 2021, one was awarded<br />
to VAI Assistant Pr<strong>of</strong>essor Dr. Stephanie<br />
Grainger. The award is worth nearly<br />
$2.4 million over the life <strong>of</strong> the award.<br />
Grainger’s project will explore a critical<br />
type <strong>of</strong> cellular communication that drives<br />
healthy development and, when disrupted,<br />
can spur cancer, osteoporosis, heart<br />
conditions and other diseases. 5<br />
Research Scholar’s Grant | American<br />
Cancer Society<br />
VAI’s Dr. Scott Rothbart earned a four-year,<br />
$792,000 Research Scholar’s Grant from<br />
the American Cancer Society to investigate<br />
the mechanisms that power a promising<br />
class <strong>of</strong> potent anti-cancer drugs. Called<br />
EZH2 inhibitors, these drugs work by<br />
targeting an enzyme named EZH2 that has<br />
long been <strong>of</strong> interest to cancer researchers<br />
because it interacts with the proteins that<br />
support DNA. As such, EZH2 plays a major<br />
role in switching genes that regulate cell<br />
proliferation “on” or “<strong>of</strong>f” — a process that<br />
can lead to cancer if it goes awry. It<br />
also helps tumors evade attack by the<br />
In 2020, VAI<br />
ranked among<br />
the top five<br />
National<br />
Institutes <strong>of</strong><br />
Health-funded<br />
organizations<br />
in Michigan,<br />
just after the<br />
state’s larger<br />
universities and<br />
health systems.<br />
immune system. 6 VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 7<br />
Source: United for Medical Research.<br />
2020. NIH in Your State: Michigan.<br />
unitedformedicalresearch.org/nih-in-yourstate/<br />
Funding Acknowledgements<br />
Research reported in this publication was supported by the National Institutes <strong>of</strong> Health under award numbers: 1 P50CA254897;<br />
2<br />
1R01HG012444; and 5 R35GM142779. The content is solely the responsibility <strong>of</strong> the authors and does not necessarily<br />
represent the <strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health<br />
3<br />
Research reported in this publication was supported by funds from Emory University as part <strong>of</strong> an Aligning Science Across<br />
Parkinson’s Collaborative Research Network award.<br />
4<br />
Research reported in this publication was supported by funds from Yale University as part <strong>of</strong> an Aligning Science Across<br />
Parkinson’s Collaborative Research Network award.<br />
6<br />
Scott B. Rothbart, Ph.D., is supported by a Research Scholar Grant, RSG-21-031-01-DMC, from the American Cancer Society.<br />
The content is solely the responsibility <strong>of</strong> the authors and does not necessarily represent the <strong>of</strong>ficial views <strong>of</strong> the granting<br />
organizations.
RESEARCH<br />
VAI scientists recognized<br />
as top <strong>of</strong> their fields<br />
It’s no secret that VAI<br />
scientists are among the<br />
world’s best. This year,<br />
five <strong>of</strong> our investigators<br />
were honored with<br />
inclusion on the Clarivate<br />
Highly Cited Researchers<br />
List, a distinction marking<br />
them as leaders in<br />
their fields.<br />
The annual list identifies<br />
scientists from around the<br />
world who demonstrate<br />
significant influence in<br />
their area <strong>of</strong> study through<br />
the publication <strong>of</strong> multiple<br />
highly cited papers during<br />
the last decade. Citations,<br />
or references, to a<br />
scientist’s published work<br />
by other researchers is<br />
universally considered to<br />
be a measure <strong>of</strong> influence<br />
and impact in the scientific<br />
community. Only about<br />
1 in 1,000 scientists in the<br />
world make this elite list,<br />
according to Clarivate.<br />
Peter A. Jones, Ph.D., D.Sc. (hon)<br />
Chief Scientific Officer<br />
Director, VAI Cancer Center<br />
Patrik Brundin, M.D., Ph.D.<br />
Deputy Chief Scientific Officer<br />
Director, VAI Parkinson’s Disease Center<br />
Read more online at bit.ly/<br />
vaihrc21<br />
Russell Jones, Ph.D.<br />
Chair, Department <strong>of</strong> Metabolism and Nutritional<br />
Programming<br />
Peter Laird, Ph.D.<br />
Pr<strong>of</strong>essor, Department <strong>of</strong> Epigenetics<br />
X. Edward Zhou, Ph.D.<br />
Senior Research Scientist, Li Lab<br />
Department <strong>of</strong> Structural Biology<br />
8 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Research highlights<br />
Looking for the latest from VAI’s scientists? Here’s a snapshot <strong>of</strong><br />
advances from the Institute’s labs.<br />
Understanding gut inflammation may hold clues to mitigating Parkinson’s onset<br />
Chronic inflammation in the gut may propel processes in the body that give rise<br />
to Parkinson’s disease, according to a study by Dr. Patrik Brundin’s lab at VAI and<br />
colleagues at Roche. The findings add to a growing list that links the gut and the<br />
immune system to Parkinson’s, and track with several large-scale studies that<br />
show an association between Parkinson’s and inflammatory bowel diseases, such<br />
as ulcerative colitis and Crohn’s disease. 1<br />
Read more at bit.ly/vaicolitis<br />
‘Roadmaps’ <strong>of</strong> the brain reveal regions vulnerable to Alzheimer’s disease<br />
Much like a supply truck crossing the countryside, the misfolded proteins<br />
that damage neurons in Alzheimer’s disease travel the “roads” <strong>of</strong> the brain,<br />
sometimes stopping or even re-routing to avoid roadblocks, reports a study by<br />
VAI’s Dr. Michael Henderson and collaborators at University <strong>of</strong> Pennsylvania.<br />
Understanding how and why this happens could clear the way for the<br />
development <strong>of</strong> new therapies to slow or stop disease progression. 2<br />
Read more at bit.ly/vaitau<br />
‘Tasty’ protein may lead to new ways to treat metabolic and immune diseases<br />
The same taste-sensing molecule that helps you enjoy a meal from your favorite<br />
restaurant may one day lead to improved ways to treat diabetes and other<br />
metabolic and immune diseases. TRPM5 is a specialized protein concentrated in<br />
the taste buds, where it helps relay messages to and from cells. It has long been<br />
<strong>of</strong> interest to researchers due to its roles in taste perception and blood sugar<br />
regulation. VAI scientists Dr. Wei Lü and Dr. Juan Du have published the firstever<br />
high-resolution images <strong>of</strong> TRPM5, which reveal two areas that may serve as<br />
targets for new medications for diseases like diabetes. These structures also may<br />
aid in the development <strong>of</strong> low-calorie alternative sweeteners that mimic sugar. 3<br />
Read more at bit.ly/vaitrpm5<br />
Study sheds light on how DNA mutates in<br />
melanoma, a deadly skin cancer<br />
The mutations that give rise to melanoma result<br />
from a chemical change in DNA fueled by sunlight<br />
— not just a DNA copying error as previously<br />
believed, reports a study by VAI’s Dr. Gerd Pfeifer.<br />
The findings upend long-held beliefs about the<br />
mechanisms underlying the disease, reinforce<br />
the importance <strong>of</strong> prevention efforts and <strong>of</strong>fer a<br />
path forward for investigating the origins <strong>of</strong> other<br />
cancer types. 4<br />
Read more at bit.ly/vaimelanoma<br />
An overactive sweet tooth may spell trouble for<br />
our cellular powerplants<br />
Although we’ve long known that eating too much<br />
sugar can contribute to Type 2 diabetes and other<br />
disorders, the exact way this overconsumption<br />
sets the stage for metabolic diseases on a cellular<br />
level has remained elusive. But now, a study led<br />
by VAI’s Dr. Ning Wu has shown that surplus<br />
sugar may cause our cellular powerplants —<br />
called mitochondria — to become less efficient,<br />
reducing their energy output. The findings<br />
highlight the cellular implications <strong>of</strong> excessive<br />
sugar consumption and provide an important<br />
new model to study the initial metabolic events<br />
that may contribute to diabetes development. 5<br />
Read more at bit.ly/vailipids<br />
Funding Acknowledgements<br />
Research reported in this publication was funded by:<br />
1<br />
Van Andel Institute and Roche. Early work on this project was supported in part by the European Research Council.<br />
2<br />
Michael J. Fox Foundation for Parkinson’s Research award no. 16879 (Henderson); the National Institute on Aging <strong>of</strong> the National Institutes <strong>of</strong> Health under awards T32AG000255 (Lee),<br />
P30AG10124 (Trojanowski) and U19AG062418 (Trojanowski);the National Institute <strong>of</strong> Neurological Disorders and Stroke <strong>of</strong> the National Institutes <strong>of</strong> Health under award nos. P50NS053488<br />
(Trojanowski) and R01NS099348 (Bassett); the National Institute <strong>of</strong> Mental Health <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. F30 MH118871-01 (Cornblath); and the National<br />
Science Foundation under award nos. PHY1554488 (Bassett) and BCS1631550 (to Bassett). Bassett also acknowledges support from the John D. and Catherine T. MacArthur Foundation, the ISI<br />
Foundation, the Alfred P. Sloan Foundation, and the Paul G. Allen Foundation.<br />
3<br />
Van Andel Institute; the National Heart, Lung, and Blood Institute <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R56HL144929 (Lü) and R01HL153219 (Lü); a McKnight Scholar Award (Du);<br />
a Klingenstein-Simons Scholar Award (Du); a Sloan Research Fellowship in neuroscience (Du); and a Pew Scholars in Biomedical Research Award from the Pew Charitable Trusts (Du).<br />
4<br />
Van Andel Institute and the National Cancer Institute <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R21CA228089 (Pfeifer).<br />
5<br />
Van Andel Institute; the National Institute <strong>of</strong> General Medical Sciences <strong>of</strong> the National Institutes <strong>of</strong> Health under award no. R01GM120129 (Wu); and the National Institute on Aging <strong>of</strong> the<br />
National Institutes <strong>of</strong> Health under award no. RF1AH061872 (Han).<br />
The content is solely the responsibility <strong>of</strong> the authors and does not necessarily represent the <strong>of</strong>ficial views <strong>of</strong> the National Institutes <strong>of</strong> Health or other granting organizations.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 9
RESEARCH<br />
Newest<br />
cohort<br />
illustrates<br />
growth at<br />
Graduate<br />
School<br />
Van Andel Institute Graduate School<br />
trains the biomedical research leaders<br />
<strong>of</strong> tomorrow, a focus that dovetails with<br />
the Institute’s overarching mission to<br />
transform human health for generations<br />
to come. We move ourselves — and the<br />
world — closer to lasting breakthroughs<br />
by welcoming a diversity <strong>of</strong> experiences,<br />
cultures and thoughts.<br />
Richard Cassidy<br />
Kansas City, Kansas<br />
Svetlana Djirackor<br />
Nairobi, Kenya<br />
In Fall 2021, the Graduate School’s largest<br />
and most diverse cohort arrived —<br />
14 students representing eight countries.<br />
The new cohort bolsters VAI’s growing<br />
reputation as a global destination for<br />
doctoral students.<br />
This array <strong>of</strong> students and perspectives<br />
helps us to better understand the full scope<br />
<strong>of</strong> health threats facing humanity. Every new<br />
cohort that arrives at VAI strengthens our<br />
organization and gives new shape to our<br />
mission; indeed, for the last few years, each<br />
successive cohort has grown larger and<br />
more diverse.<br />
S<strong>of</strong>ia Ievleva<br />
Voronezh, Russia<br />
Yanqing Liu<br />
Shandong Province, China<br />
The 2021 cohort includes students from<br />
The Bahamas, China, India, Iran, Kenya,<br />
Russia, the U.K. and the U.S. Although their<br />
paths were different, they arrived here<br />
united in one goal: to become the leaders<br />
who take us into the bright future where<br />
diseases like cancer and Parkinson’s are met<br />
with life-changing treatment and care.<br />
Kate Thurlow<br />
London, United Kingdom<br />
Xiao Wang<br />
Yunnan Province, China<br />
10 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
James Eapen<br />
Cochin, India<br />
Abigail Godec<br />
Denver, Colorado<br />
Thomas Goralski<br />
Livonia, Michigan<br />
Paige Matusiak<br />
LaGrange Highlands, Illinois<br />
Shantinique Miller<br />
Nassau, The Bahamas<br />
Christina Straham<br />
Flint, Michigan<br />
Riley Wedan<br />
Savage, Minnesota<br />
Mehrshid Faraji Zonooz<br />
Tehran, Iran<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 11
RESEARCH<br />
A day in the life <strong>of</strong> a VAI<br />
Graduate School student<br />
The life <strong>of</strong> a VAI graduate student varies greatly from year to year.<br />
Some years are spent more in the classroom, and others in the lab.<br />
But no matter how a student’s typical day looks, they are all working<br />
toward careers as biomedical research leaders.<br />
Nadia Dehghani is a third-year Ph.D. student in the labs <strong>of</strong> Dr. Rita<br />
Guerreiro and Dr. José Brás. Nadia studies genetic contributors to<br />
dementia. We caught up with her to get a glimpse into the life <strong>of</strong> a<br />
VAI grad student.<br />
What does a typical day with your thesis research look like?<br />
Days can be vastly different from one another, or vastly different<br />
from what was “ideally” planned! My time is generally spread across<br />
ongoing projects at varying milestones — data generation and<br />
troubleshooting, data analysis and write-up, and responding to peer<br />
reviewers who <strong>of</strong>fer feedback on my research.<br />
Additional daily constants include discussing and consolidating<br />
approaches to projects and reading newly published scientific<br />
studies. These can be directly related to my thesis research, or may<br />
<strong>of</strong>fer a new approach for me to consider. Most days, I also engage<br />
with a scientific seminar or a formal class; this semester,<br />
I have enrolled in the fantastic Lab Leadership class organized by<br />
Dr. J. Andrew Pospisilik, chair <strong>of</strong> VAI’s Department <strong>of</strong> Epigenetics.<br />
How has the Graduate School’s unique setup benefited your<br />
studies and research?<br />
We are very fortunate to be led by the vision and philosophy <strong>of</strong><br />
Dean Dr. Steven J. Triezenberg. With our highly dedicated and<br />
supportive Graduate School staff, we’ve cultured a stimulating and<br />
collegial environment where graduate students are seamlessly<br />
integrated within VAI.<br />
Most recently, we moved into new, designated facilities on VAI’s<br />
campus for students’ scholarly and pr<strong>of</strong>essional development — a<br />
result <strong>of</strong> the Graduate School’s exciting growth and recognition. As<br />
students, developments in our research approaches are aided by<br />
perspectives from peers and mentors; the growing diversity within<br />
the Graduate School makes this possible and increasingly practical.<br />
To learn more about VAI Graduate School, visit vaigs.vai.org.<br />
(STARTING AT LEFT, GOING ACROSS) NADIA DEHGHANI<br />
& DR. RITA GUERREIRO; LEENA KARIAPPER PRESENTING AT VAI GRADUATE SCHOOL<br />
12 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Graduate School<br />
highlights<br />
Origins <strong>of</strong> Cancer probes intersection <strong>of</strong> cancer, neuroscience<br />
The 2021 Origins <strong>of</strong> Cancer symposium, held in July, explored the intersection <strong>of</strong> cancer<br />
and neuroscience, an area that holds great promise for better understanding the complex<br />
biological interactions that give rise to disease. Students and scientists joined together<br />
for the virtual conference to discuss how the future <strong>of</strong> cancer research may combine two<br />
discrete areas <strong>of</strong> study by exploring the common threads that unite them. This annual<br />
event, organized and hosted by VAI Graduate School students, serves as a shining example<br />
<strong>of</strong> collaboration — a value that is at the heart <strong>of</strong> VAI’s ethos.<br />
Taylor Boyd joins Graduate School leadership<br />
The Institute’s commitment to training the scientific leaders <strong>of</strong> tomorrow leapt forward in<br />
October 2021 with the hiring <strong>of</strong> Taylor Boyd as director <strong>of</strong> assessment and pr<strong>of</strong>essional<br />
development. Boyd, who previously served in the Office <strong>of</strong> the Provost at Grand Valley<br />
State University, is responsible for assessing the Graduate School’s curriculum and cocurricular<br />
activities. He also assists VAI faculty in enhancing their teaching and mentoring<br />
skills, as well as in monitoring the progress <strong>of</strong> student learning. Boyd will also lead the work<br />
to sustain the Graduate School’s accreditation.<br />
3 quick facts<br />
about VAI<br />
Graduate School<br />
• The Graduate School has<br />
graduated 34 students to date: 30<br />
Ph.D. and four M.S. Of the<br />
30 Ph.D. graduates:<br />
70% have gone to postdoctoral or<br />
research associate positions<br />
20% have taken positions in industry<br />
• As <strong>of</strong> September 2021, 44 students<br />
were enrolled in our Ph.D. program.<br />
The student body includes:<br />
28 women<br />
13 international students<br />
2 students from populations<br />
underrepresented in the biomedical<br />
workforce (by NIH standards)<br />
4 students enrolled in dual-degree<br />
(M.D.-Ph.D.) programs<br />
• In 2020, Graduate School<br />
students and alumni contributed<br />
24 authorships on 17 research<br />
publications, with 12 authorships on<br />
11 papers in 2021.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 13
EDUCATION<br />
From Afterschool Cohort to<br />
Fulbright Scholar: One student’s<br />
journey with VAI<br />
Van Andel Institute for Education strives to foster a love <strong>of</strong><br />
learning in every student who walks through our doors. Whether<br />
they join us for a field trip or attend one <strong>of</strong> VAI’s Afterschool<br />
Cohorts, our mission is to teach them how to think and act like<br />
a scientist.<br />
Former Afterschool Cohort student Eli Bieri exemplifies the impact<br />
<strong>of</strong> our work. Bieri, a passionate and curious scientist, was recently<br />
awarded a Fulbright Scholarship to pursue work in amphibian<br />
conservation.<br />
“I remember hearing toad calls when I was a little kid, in the<br />
summertime from my backyard, and I was just innately drawn to<br />
that noise,” Bieri said. “From then on, I spent so much free time<br />
just wading through ponds and swamps, looking for frogs and<br />
snakes and turtles.”<br />
“I remember doing this project where I was testing what effect<br />
common pesticides or herbicides would have on African Clawed<br />
Frogs. What I really loved about that project was that I felt like the<br />
instructor really treated me like a scientist,” Bieri said. “He was like,<br />
‘You are scientists! You’re doing science!’ That’s the kind <strong>of</strong> thinking<br />
that translates into a career in science, and I’m really grateful<br />
for that.”<br />
These days, as a Fulbright Scholar, Bieri is participating in a two-year<br />
master’s program at the University <strong>of</strong> New South Wales in Sydney,<br />
Australia. Working with Dr. Jodi Rowley, he studies how aggressive<br />
wildfire suppression may negatively impact the country’s amphibian<br />
population. Bieri and Rowley hope their research will lead to better,<br />
more sustainable practices for both humans and amphibians<br />
alike. Eventually, Bieri would like to work at the intersection <strong>of</strong> land<br />
management and public policy.<br />
“I remember hearing toad calls when I was a little kid,<br />
in the summertime from my backyard, and I was just<br />
innately drawn to that noise. From then on, I spent<br />
so much free time just wading through ponds and<br />
swamps, looking for frogs and snakes and turtles.”<br />
— Eli Bieri<br />
As he grew, Bieri searched for new ways to satisfy his inquisitive<br />
nature. When a family friend received a pamphlet on VAI’s student<br />
programs, she thought <strong>of</strong> Bieri and passed the information on to<br />
his mother. That small decision would ultimately set Bieri on his<br />
trajectory toward a career in science and biology.<br />
While enrolled in Afterschool Cohort, Bieri quickly realized<br />
he’d found a place where his curiosity could be channeled into<br />
something productive and fun. Cohorts are designed around<br />
hands-on investigations where students ask questions and<br />
discover answers using scientific tools and resources. In fact, the<br />
classrooms at VAI for Education are home to many <strong>of</strong> the same<br />
reptiles and amphibians Bieri <strong>of</strong>ten searched for in his backyard.<br />
“VAI had a significant impact on Eli’s natural curiosity,” said his<br />
mother, Gail Greco-Bieri. “It was the spark that lit the fire for him to<br />
validate the ‘whys’ he thought about, and he continues to question<br />
today. VAI taught Eli to think like a scientist, and he’s not stopped<br />
ever since.”<br />
We are grateful to the Rottman Family Charitable Foundation for their<br />
support <strong>of</strong> Afterschool Cohort.<br />
ELI BIERI<br />
14 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 15
EDUCATION<br />
In-person field trips return at<br />
Van Andel Institute for Education<br />
In the early days <strong>of</strong> the pandemic, Van Andel Institute<br />
for Education pivoted to <strong>of</strong>fer our suite <strong>of</strong> student and<br />
teacher programs in a virtual format. We knew that<br />
educators, parents and kids were in uncharted territory,<br />
and we worked swiftly to support them where they needed<br />
us most.<br />
At the start <strong>of</strong> the 2021–22 academic year, the Institute<br />
returned to an in-person format for one <strong>of</strong> our most<br />
popular <strong>of</strong>ferings: field trips. With appropriate safety<br />
protocols and masking in place, we welcomed classrooms<br />
back to our educational labs at 216 Division Ave. As <strong>of</strong><br />
January <strong>2022</strong>, there have been 23 field trips serving more<br />
than 400 students for this academic year.<br />
Our educational philosophy is guided by the principle that<br />
immersive, hands-on scientific investigations are best for<br />
creating classrooms where curiosity, creativity and critical<br />
thinking thrive. Although we successfully <strong>of</strong>fered virtual<br />
field trips for months, and continue to do so upon request,<br />
it was clear that all <strong>of</strong> us missed the benefits <strong>of</strong> in-person<br />
learning.<br />
“We are so happy to have students back in our labs,<br />
doing experiments that get them thinking and acting like<br />
scientists and nurturing a curiosity for the world around<br />
us,” said Terra Tarango, director and chief education <strong>of</strong>ficer<br />
<strong>of</strong> Van Andel Institute for Education. “We will always work<br />
tirelessly to create fun, safe learning environments for<br />
every student who walks through our doors.”<br />
To learn more about our field trip <strong>of</strong>ferings, visit vaei.org.<br />
(STARTING AT TOP RIGHT, GOING CLOCKWISE) STUDENTS FROM<br />
CROSSROADS CHARTER ACADEMY COLLABORATE; TWO CLASSMATES<br />
EXAMINE THE PROPERTIES OF GLITTER; STUDENTS PREPARE TO CONDUCT<br />
AN EXPERIMENT DURING THEIR FIELD TRIP TO VAI FOR EDUCATION;<br />
STUDENTS WORK TOGETHER DURING FIELD TRIPS TO VAI FOR EDUCATION<br />
16 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Education highlights<br />
The pandemic has brought many challenges to the classroom. Our educators worked<br />
hard to make sure that teachers and administrators could support students to the<br />
best <strong>of</strong> their ability with a suite <strong>of</strong> instructions, resources, projects and pr<strong>of</strong>essional<br />
development <strong>of</strong>ferings to help create classrooms where curiosity, creativity and critical<br />
thinking continue to thrive. Resources mentioned here can be found at vaei.org.<br />
Better Together: A Virtual Event for K–12 Administrators<br />
To combat learning loss, VAI hosted several networking events for K–12<br />
administrators to help address concerns related to the pandemic. More than<br />
350 administrators from 20 states and two continents have registered for Better<br />
Together events.<br />
VAI’s Admin Guides<br />
These relevant and comprehensive guides are designed to equip administrators<br />
with strategies for school development. This year featured “Beyond Learning<br />
Loss: Six Ways Schools Can Thrive in the Aftermath <strong>of</strong> the Pandemic” and “7 Tips<br />
for Successful School Improvement Planning.” The Admin Guides have been<br />
downloaded more than 500 times.<br />
Blue Apple Timely Topics<br />
Our expert educators created nine free Blue Apple Timely Topics connecting to<br />
current events, such as “Celebrating Black History Month,” “Respectful Debate”<br />
and “Spooktacular STEAM.” In 2021, these lessons were downloaded more<br />
than 2,800 times and were used throughout the U.S. and more than 25 other<br />
countries.<br />
Flex PD<br />
VAI’s popular Flex PD is a comprehensive, affordable pr<strong>of</strong>essional development<br />
model that promotes tangible shifts in instruction for teachers and<br />
administrators. Our plans are customizable to fit educators’ individual needs and<br />
include immersive workshops, learning sessions and coaching.<br />
NexGen Inquiry Quests<br />
Our new NexGen Inquiry Quests are story-driven video lessons that capture<br />
student interest by introducing them to real-world problems they can solve<br />
with hands-on, scientific investigations. Each Quest includes three inquirybased<br />
investigations that help students exercise critical and creative thinking,<br />
collaboration with peers, and the application <strong>of</strong> solutions that will make the world<br />
a better place. In one Quest, students play the role <strong>of</strong> an electrical engineer who<br />
is troubleshooting a power outage. In another, students learn “crime scene”<br />
forensics to locate a reptile that’s gone “missing” from VAI’s classrooms.<br />
“Once again, thank<br />
you for supporting<br />
our teachers. You<br />
(VAI) have been a<br />
wonderful asset and<br />
support system as<br />
our teachers navigate<br />
implementing projectbased<br />
learning in our<br />
schools.”<br />
— Hilary B.,<br />
Allegan Public Schools<br />
Field Trips<br />
Our field trips immerse students — and their teachers — in learning science<br />
through investigation. Students conduct unique, grade-specific investigations and<br />
participate in hands-on discovery with activities like mock fossil digs, engineering<br />
challenges and robotics coding. After being held virtually for the 2020–21<br />
school year, field trips returned to an in-person format with appropriate safety<br />
precautions in fall 2021.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 17
EVENTS<br />
VAI Golf Outing<br />
In September, golfers gathered at the majestic Wuskowhan<br />
Players Club in West Olive, Michigan, for the 14th annual<br />
VAI Golf Outing. The 2021 event featured a scramble<br />
tournament, lunch, dinner and a brief award presentation.<br />
For nearly 15 years, the VAI Golf Outing has brought the golf<br />
community <strong>of</strong> West Michigan together in support <strong>of</strong> the<br />
Institute’s biomedical research and educational programs.<br />
Thank you to our Title Sponsor, the Veldheer, Long, Mackay &<br />
Bernecker Group <strong>of</strong> Merrill Lynch.<br />
(STARTING AT TOP RIGHT, GOING CLOCKWISE) CAROL VAN ANDEL; MOLLY KRAUSE, KAREN CUSTER, KELLIE CUSTER & TERRI DEBOER;<br />
DAVID VAN ANDEL KICKS OFF THE DAY; ANN CALLAHAN & SHAWN PREMER; RYAN FORMSMA,<br />
ERIC HELZER, CHRISTOPHER STRALKOWSKI & STAN ELENBAAS<br />
18 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Please note: All events followed health and safety protocols related to the<br />
COVID-19 pandemic in place at the time <strong>of</strong> occurrence.<br />
Couture for a Cure<br />
Back live and in action, Couture for a Cure brought glitz, glam and<br />
generosity together at the Institute for a 16th year. The event<br />
featured a New York-style runway show by Leigh’s and highlighted<br />
the Fall 2021 collection <strong>of</strong> designer Veronica Beard. Co-founders<br />
<strong>of</strong> the eponymous brand — Veronica Miele Beard and Veronica<br />
Swanson Beard — shared a special virtual message with the<br />
evening’s guests, who also enjoyed a seated dinner, table service<br />
and fabulous musical stylings from AB. Guests also learned more<br />
about VAI’s work into ovarian cancer research. New products and<br />
on-trend looks from Artistry appeared on the runway, and all<br />
guests took home swag bags <strong>of</strong> exclusive gifts, treats and Artistry<br />
products.<br />
Thank you to our Presenting Sponsor, Leigh’s, and our<br />
Title Sponsor, Amway.<br />
(STARTING AT TOP RIGHT, GOING CLOCKWISE) SCOTT & REBECCA WIERDA WITH DAVID & CAROL VAN ANDEL; MODEL ON THE RUNWAY; MODEL SHOWING<br />
OFF ONE OF THE NIGHT’S CHIC LOOKS; CAROL VAN ANDEL; CONSUMERS CREDIT UNION’S LYNNE JARMAN-JOHNSON (CENTER, IN BLACK & GOLD)<br />
WITH A GREAT GROUP OF GUESTS AT THE EVENT ENTRANCE; MODEL SHOWS OFF A GLAMOROUS LOOK ON THE RUNWAY<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 19
EVENTS<br />
<strong>Hope</strong> on the Hill Gala<br />
As the culminating event <strong>of</strong> our 25th anniversary, the 21st<br />
annual <strong>Hope</strong> on the Hill Gala marked a quarter century <strong>of</strong><br />
progress at the Institute with a night <strong>of</strong> glamour, mystery<br />
and support <strong>of</strong> VAI’s mission. Guests broke out their best<br />
black-tie attire to celebrate those who, for the past 25 years,<br />
have helped make great strides at the Institute: our donors,<br />
our community, and the scientists and educators they support.<br />
The event included a seated dinner <strong>of</strong> delectable cuisine and<br />
artisan cocktails, live entertainment from AB and world-class<br />
electroviolinist Svet, and presentations from Institute leaders on<br />
VAI’s history, breakthroughs and dreams for the future.<br />
Thank you to our Title Sponsor, Fifth Third Private Bank.<br />
20 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Thank you to all donors and guests who<br />
supported us through our virtual events in<br />
2021, including:<br />
• VAI Forum on Depression & Inflammation<br />
• Carol Van Andel Angel <strong>of</strong> Excellence Virtual Dinner<br />
& Award Presentation<br />
• Grand Rapids Griffins VAI Purple Community Game<br />
• Board <strong>of</strong> Governors Annual Dinner<br />
• Around the World<br />
• VAI Public Lecture Series<br />
• Virtual C<strong>of</strong>fee Connection Events<br />
While we wish we could have seen more <strong>of</strong> you in person<br />
in 2021, we are so happy you were able to join us in some<br />
capacity to celebrate VAI’s research and education efforts<br />
from the last year — and the last quarter century.<br />
(STARTING AT TOP LEFT, GOING CLOCKWISE) SENATOR MARK HUIZENGA<br />
& KRIS HUIZENGA, BILL & MARY JACKSON, RUSTY & JENN MERCHANT &<br />
MAUREEN WATSON-BOLGER & MATT BOLGER (FAR RIGHT);<br />
DAVID & CAROL VAN ANDEL; JAKE KENNARD & KATE ZWIERS &<br />
NICOLE & DAVID ZWIERS; SVET; DAVID VAN ANDEL;<br />
ENTRYWAY TO THE EVENT; DJ AB<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 21
EVENTS<br />
A Conversation About Pancreatic<br />
Cancer — Hosted by<br />
Carol Van Andel<br />
Despite incredible advances in cancer detection and treatment,<br />
pancreatic cancer continues to pose a particular challenge to<br />
physicians and patients because it <strong>of</strong>ten lacks obvious early<br />
symptoms. By the time the disease is found, it is typically quite<br />
advanced, complicating treatment and leading to poorer patient<br />
outcomes.<br />
Thanks to new breakthroughs, there is hope. In November,<br />
guests at A Conversation About Pancreatic Cancer — Hosted by<br />
Carol Van Andel learned about the latest advances in pancreatic<br />
cancer research, with a focus on promising opportunities for<br />
early detection. Speakers included pancreatic cancer experts<br />
Dr. Brian Haab, a VAI pr<strong>of</strong>essor whose lab is at the forefront <strong>of</strong><br />
new diagnostic efforts, and Dr. J. Bradley Morrow, director <strong>of</strong><br />
endoscopy at Mercy Health St. Mary’s. For the past five years,<br />
Drs. Haab and Morrow have collaborated on developing new<br />
diagnostics for pancreatic cancer.<br />
Thank you to our Presenting Sponsor, The Howard Miller Company.<br />
(STARTING AT TOP RIGHT, GOING CLOCKWISE) CAROL VAN ANDEL; GUESTS HEAR FROM DR. BRIAN HAAB;<br />
DR. J. BRADLEY MORROW AND MARANDA; DR. J. BRADLEY MORROW<br />
22 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Gaming for <strong>Hope</strong><br />
In 2021, VAI hosted our inaugural Gaming for <strong>Hope</strong>, a fully<br />
online, 24-hour gaming marathon that blended a passion for<br />
online gaming and streaming with raising funds to support the<br />
Institute’s work. Streamers <strong>of</strong> all ages and experience levels played<br />
numerous games over the course <strong>of</strong> the day, including singleplayer<br />
FIFA 21, Super Smash Bros. Ultimate, League <strong>of</strong> Legends,<br />
and Counter-Strike: Global Offensive. Featured streamers joined in<br />
on the action, and giveaways and prizes were up for grabs for those<br />
who fundraised for the Institute.<br />
Thank you to our Presenting Sponsor, Element Four.<br />
(STARTING AT TOP LEFT, GOING CLOCKWISE) COLIN GRAHAM & DAVENPORT ESPORTS INTERN; MAE LEXI ZURITA;<br />
COLIN GRAHAM; MIKE “POROSAURUS” NAVARRO<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 23
EVENTS<br />
Thank you to our generous<br />
event sponsors<br />
To learn more about sponsoring an event, contact Sarah Rollman at<br />
sarah.rollman@vai.org.<br />
Winterfest Celebration<br />
Rob & Dawn Arnoys<br />
Steven & Amanda Barbour<br />
Bluewater Technologies<br />
Jerry & Suzanne Callahan<br />
Custer Inc.<br />
Mike & Jean Dery<br />
Edge Natural Resources<br />
Ernst & Young<br />
Grand Rapids Christian Schools<br />
HB Wealth Management<br />
Hines Corporation<br />
Dr. Jurgen & Becky Luders<br />
Macatawa Bank<br />
McShane & Bowie PLC<br />
Mercy Health<br />
MMS Education<br />
Mike & Sally Murdock<br />
Owen-Ames-Kimball Co.<br />
P.L. Capital<br />
Pioneer Construction<br />
Red Glasses Movement<br />
Rockford Construction<br />
Sharpe<br />
Warner Norcross + Judd LLP<br />
Ge<strong>of</strong>f & LeeAnne Widlak<br />
Around the World<br />
James & Shirley Balk<br />
Jerry & Suzanne Callahan<br />
Brian DeVries & Barbara Pugh<br />
Caledonia Dental Group<br />
Greenridge Realty, Inc.<br />
Huizenga Group<br />
John Hancock Financial Services<br />
Lake Michigan Credit Union<br />
Leigh’s<br />
The Meijer Foundation<br />
Mike & Rachel Mraz<br />
Lee & Alexandra Perez<br />
Lisa M. Rose & Dr. Ken H<strong>of</strong>fman<br />
West Michigan Woman<br />
This list includes sponsors <strong>of</strong> 2021 signature events.<br />
Design & Discovery<br />
Alpine Events<br />
Autocam Medical<br />
Franco & Alessandra Bianchi<br />
Bluewater Technologies<br />
Robert & Sandra Borsos<br />
The Brooks Family<br />
Byrne Electrical Specialists<br />
Cascade Engineering<br />
Cauley Ferrari <strong>of</strong> Detroit<br />
Cottage Home<br />
The Currie Foundation<br />
Randy Damstra & Julie Duisterh<strong>of</strong><br />
David & Carol Van Andel Family<br />
Foundation<br />
Dominique & Julie DeNooyer<br />
Dunn & Laug Wealth<br />
Mike & Barb Ellis<br />
Ernst & Young<br />
EV Construction<br />
Geerlings Development<br />
Company/Midwest Construction<br />
Group<br />
Jeff & Ann Harten<br />
Matt & Jen Haworth<br />
Heidi Huizenga<br />
The Hilldore Group — Baird<br />
Holland Hospital<br />
Inontime<br />
James Group<br />
Jeffery Roberts Design<br />
Kyle Geenen Group<br />
Al & Linda Lanning<br />
Management at Morgan Stanley<br />
Michigan Homes & Cottages<br />
Mike Schaap Builders, Inc.<br />
Paul & Anne Nemsch<strong>of</strong>f<br />
Nicolai North America<br />
Padnos<br />
Priority Health<br />
Progressive AE<br />
Rowerdink Inc.<br />
Marc & Jeanne Schupan<br />
SeyferthPR<br />
SIBSCO<br />
24 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE<br />
Spectrum Health<br />
Craig & Wendy Spoelh<strong>of</strong><br />
John & Judy Spoelh<strong>of</strong><br />
Scott & Jan Spoelh<strong>of</strong><br />
Kathleen Stewart Ponitz<br />
Kenneth & Nancy Teutsch<br />
Visbeen Architects Inc.<br />
Warner Norcross + Judd LLP<br />
West Michigan Woman<br />
Woodways International<br />
YMCA <strong>of</strong> Greater Grand Rapids<br />
VAI Golf Outing<br />
Applied Imaging<br />
Bluewater Technologies<br />
Bouma Corporation<br />
Consumers Credit Union<br />
Cornerstone University<br />
Custer Inc.<br />
Erhardt Construction<br />
First National Bank<br />
Gallagher Insurance<br />
Grand Rapids Christian Schools<br />
Ben & Molly Hunting<br />
Loomis, Sayles & Company, L.P.<br />
Macatawa Bank<br />
Merrill Lynch — Veldheer, Long,<br />
Mackay & Bernecker Group<br />
Metro Health — University <strong>of</strong><br />
Michigan Health<br />
Midwest Capital Advisors<br />
Northern Jet Management<br />
Owen-Ames-Kimball Co.<br />
Pine Rest<br />
Priority Health<br />
John & Therese Rowerdink<br />
Secrest Wardle<br />
Sharpe<br />
Standard Lumber<br />
Thomas & Mary Stuit<br />
Summit Point Ro<strong>of</strong>ing<br />
US Signal<br />
Brian & Lori Vander Baan<br />
Dave & Beth VanPortfliet<br />
Wells Fargo<br />
West Michigan Woman<br />
Couture for a Cure<br />
Amway<br />
Andy J. Egan Company<br />
Bluewater Technologies<br />
Chuck & Christine Boelkins<br />
Cheeky Strut<br />
Consumers Credit Union<br />
Mimi Cummings<br />
CWD Real Estate Investment<br />
David & Carol Van Andel Family<br />
Foundation<br />
Deloitte<br />
Brian DeVries & Barbara Pugh<br />
Eileen DeVries Family Foundation<br />
Eurest<br />
First National Bank <strong>of</strong> Michigan<br />
Gallagher<br />
Jana Hall<br />
Paul & Sheryl Haverkate<br />
J.C. & Tammy Huizenga<br />
Bill & Starr Humphries<br />
Jandernoa Foundation<br />
Jeffery Roberts Design<br />
Dr. Peter & Veronica Jones<br />
Kool Auto Group<br />
Lake Michigan Credit Union<br />
McAlvey Merchant & Associates<br />
Priority Health<br />
Rockford Construction<br />
The Steve & Amy Van Andel<br />
Foundation<br />
West Michigan Woman<br />
Greg & Meg Willit<br />
Zip Xpress, Inc.<br />
<strong>Hope</strong> on the Hill Gala<br />
Advantage Commercial Real<br />
Estate<br />
Al & Robin Koop Foundation<br />
Amway<br />
Aon<br />
Aquinas College<br />
AssurancePlus<br />
Autocam Medical<br />
John & Ginny Baysore<br />
Jeff & Meg Bennett<br />
Betz Industries
BHS Insurance<br />
Dave & Jill Bielema<br />
Bluewater Technologies<br />
Chuck & Christine Boelkins<br />
Buist Electric<br />
Jerry & Suzanne Callahan<br />
Cancer & Hematology Centers <strong>of</strong><br />
Western Michigan, P.C.<br />
Consumers Credit Union<br />
Ryan & Jessica Cook<br />
Crowe LLP<br />
Tom & Tracy Curran<br />
Custer Inc.<br />
Czech Asset Management<br />
Davenport University<br />
David & Carol Van Andel Family<br />
Foundation<br />
Deloitte<br />
Dick & Betsy DeVos Family<br />
Foundation<br />
The Douglas & Maria DeVos<br />
Foundation<br />
Eenhoorn<br />
Pete & LeAnn Engles<br />
Fifth Third Private Bank<br />
Gallagher Insurance<br />
Grand Valley State University<br />
Martin & Peggy Greydanus<br />
Jana Hall<br />
Kurt & Madelon Hassberger<br />
<strong>Hope</strong> College<br />
Howard Miller<br />
Huizenga Group<br />
ICN Foundation<br />
Jandernoa Foundation<br />
Matt & Sarah Jones<br />
Dr. Peter & Veronica Jones<br />
Craig & Debra Kinney<br />
Blake & Mary Krueger<br />
John & Katie Kuiper<br />
Lake Michigan Credit Union<br />
Ray & Jeannine Lanning<br />
Gary & Vicky Ludema<br />
Macatawa Bank<br />
McAlvey Merchant & Associates<br />
Meijer<br />
The Meijer Foundation<br />
Merrill Lynch — The Veldheer,<br />
Long, Mackay & Bernecker<br />
Group<br />
Michigan State University College<br />
<strong>of</strong> Human Medicine<br />
Bill & Pat Mills<br />
New Holland Brewing Co.<br />
Northern Jet Management<br />
NPF Investment Advisors<br />
Owen-Ames-Kimball Co.<br />
Pageworks<br />
Peter C. & Emajean Cook<br />
Foundation<br />
The Peter F. Secchia Family<br />
Pioneer Construction<br />
Pitsch Companies<br />
Plastic Surgery Associates/Grand<br />
Pearl Spa<br />
Priority Health<br />
Quality Air Service<br />
Rockford Construction<br />
Eve Rogus & Paul Becker<br />
Rowerdink Inc.<br />
Tony & Dawn Semple<br />
Sharpe<br />
Spectrum Health<br />
David & Linda Spencer<br />
Rob & Susan Stafford<br />
Steelcase Inc.<br />
Stephen Klotz Family Foundation<br />
The Steve & Amy Van Andel<br />
Foundation<br />
Taconic<br />
Thomas S. Fox Family<br />
Truscott Rossman<br />
University <strong>of</strong> Michigan Health<br />
West<br />
Mike & Michelle Van Dyke<br />
Dan & Ann Van Eerden<br />
Christian & Kara VerMeulen<br />
Russ & Chris Visner<br />
Warner Norcross + Judd LLP<br />
Wells Fargo<br />
West Michigan Woman<br />
Williams Kitchen & Bath<br />
Wolverine Worldwide<br />
Jim & Jane Zwiers<br />
A Conversation About Pancreatic<br />
Cancer — Hosted by<br />
Carol Van Andel<br />
Autocam Medical<br />
Bluewater Technologies<br />
Gallagher Insurance<br />
Howard Miller<br />
Leigh’s<br />
West Michigan Woman<br />
Dr. Bart & Wendy Williams<br />
Gaming for <strong>Hope</strong><br />
Bluewater Technologies<br />
Element Four<br />
Herman Miller<br />
Mercantile Bank <strong>of</strong> Michigan<br />
NVINT<br />
Service Express<br />
Varnum<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 25
VAI PURPLE COMMUNITY<br />
VAI Purple Community<br />
partners put in the time,<br />
effort and talent<br />
As one <strong>of</strong> Van Andel Institute’s core values, collaboration plays a central role in all<br />
work done at the Institute.<br />
Whether it’s the latest research breakthroughs in cancer and Parkinson’s,<br />
educational innovations for K–12 and graduate students, or well-crafted plans for<br />
signature events, we know the meaning <strong>of</strong> working together for something bigger<br />
than us.<br />
Our incredible community partners hold collaboration in high esteem, too. They<br />
work directly with the grassroots fundraising program VAI Purple Community to<br />
put their time, effort and connections to use in supporting VAI’s work. In 2021, VAI<br />
Purple Community programs raised more than $380,000, which — like all funds<br />
raised through VAI community and signature events — goes directly to the research<br />
and education programs at VAI.<br />
Here are just a few highlights from last year’s VAI Purple Community events:<br />
• West Ottawa Public Schools put on fundraisers all year long in support <strong>of</strong> VAI.<br />
In a typical year, each West Ottawa sports team holds a Purple Game, with the<br />
proceeds going directly to VAI’s work. While 2021 was certainly not a normal year,<br />
the girls’ soccer team was able to hold their Purple Game at the end <strong>of</strong> the 2020–21<br />
school year. The players wore specially made jerseys featuring the names <strong>of</strong> people<br />
dear to them who have been affected by cancer, Parkinson’s or another disease — a<br />
tangible reminder <strong>of</strong> why we do the work we do here at the Institute.<br />
• Otsego Public Schools hold a huge football game in support <strong>of</strong> VAI every other<br />
year, thanks in large part to Holly McCaw, Otsego’s director <strong>of</strong> communications and<br />
a 2020 recipient <strong>of</strong> the Carol Van Andel Angel <strong>of</strong> Excellence Award. In 2021, they had<br />
to postpone their VAI Purple Community event to the spring, which required some<br />
creativity. Out <strong>of</strong> that came the first-ever VAI Purple Community Otsego 5K, featuring<br />
purple shirts, purple dust throws at race checkpoints and more. Organizers hosted<br />
games throughout the week leading up to the race, and a carnival closed out<br />
race day.<br />
• Duncan Lake Middle School has partnered with VAI for many years for its<br />
annual cancer walk. In 2021, the walk was held outside in the spring. Attendees<br />
could donate to dunk a teacher, participate in a silent auction online, or purchase a<br />
variety <strong>of</strong> popsicles, ice cream and other cool treats, with all funds going directly to<br />
cancer research at the Institute.<br />
To learn more about VAI Purple Community and how to start your own event, visit<br />
purplecommunity.org.<br />
(STARTING AT TOP, GOING DOWN) RUNNERS RACE<br />
ACROSS THE FINISH LINE AT VAI PURPLE COMMUNITY<br />
OTSEGO 5K; WHEN NOT RACING, ATTENDEES COULD TRY<br />
TO DUNK A TEACHER; A GOLF CART DECKED OUT FOR<br />
THE OCCASION; RUNNERS WERE COVERED IN PURPLE<br />
POWDER AT RACE CHECKPOINTS<br />
26 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
(STARTING AT TOP LEFT,<br />
GOING CLOCKWISE) WALKERS<br />
DECKED OUT IN PHOTO PROPS<br />
BEFORE THE RACE; ATTENDEE<br />
SHIRTS FEATURED NAMES OF<br />
LOVED ONES HONORED IN<br />
THE WALK; WALKERS TAKE A<br />
BREAK TO HAVE FUN HULA<br />
HOOPING; A GROUP OF<br />
WALKERS MOVES AROUND<br />
THE TRACK; AN ATTENDEE<br />
SHARING WHAT THE CANCER<br />
WALK MEANS TO HER;<br />
WALKERS PARTICIPATING IN<br />
FUN AND GAMES WHEN NOT<br />
ON THE TRACK<br />
(STARTING AT FAR LEFT, GOING<br />
CLOCKWISE) SPECTATORS<br />
CHEER ON THE ATHLETES;<br />
ATTENDEES SHOWING OFF<br />
THEIR VAI PURPLE COMMUNITY<br />
SWAG IN THE STANDS; A WEST<br />
OTTAWA PLAYER LAUNCHES<br />
THE BALL DOWN THE FIELD;<br />
WEST OTTAWA GIRLS’ SOCCER<br />
TEAM CELEBRATING THEIR<br />
SUCCESSFUL FUNDRAISING<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 27
VAI PURPLE COMMUNITY<br />
VAI Marathon Team runners back<br />
in action at four global marathons<br />
With marathons around the world<br />
canceled, postponed or downsized in<br />
2020 and 2021 due to the COVID-19<br />
pandemic, Van Andel Institute Marathon<br />
Team runners also found themselves in<br />
a holding pattern. They were ready and<br />
excited to run a world-class marathon and<br />
raise funds in support <strong>of</strong> VAI’s research and<br />
education efforts, but many had to wait to<br />
put all that energy to good use.<br />
After two years <strong>of</strong> waiting and a smallerthan-usual<br />
number <strong>of</strong> runners in the 2021<br />
races — the number <strong>of</strong> runners allowed in<br />
each race was capped as part <strong>of</strong> health and<br />
safety precautions — the VAI Marathon<br />
Team is coming back strong in <strong>2022</strong>, with<br />
a limited number <strong>of</strong> complimentary entries<br />
to four races for runners fundraising on<br />
behalf <strong>of</strong> the Institute:<br />
• BMW Berlin Marathon: Sept. 25<br />
• TCS London Marathon: Oct. 2<br />
• Bank <strong>of</strong> America Chicago Marathon: Oct. 9<br />
• TCS New York City Marathon: Nov. 6<br />
Each year, dedicated runners train for<br />
these world-renowned races while raising<br />
funds for the Institute. They have each<br />
been touched by the diseases studied by<br />
VAI scientists (including cancer, Parkinson’s,<br />
and Alzheimer’s and related dementias),<br />
whether through a loved one’s diagnosis or<br />
even their own. Each <strong>of</strong> them understands<br />
the incredible value <strong>of</strong> the Institute’s K–12<br />
and graduate education programs that are<br />
training the next generation <strong>of</strong> scientific<br />
leaders. And each <strong>of</strong> them wants to do their<br />
part to make sure our efforts can continue<br />
to improve health and enhance lives for<br />
years to come.<br />
“Running a marathon is tough, and training<br />
for a marathon is grueling,” said former VAI<br />
Marathon Team member McKenzie Hollern<br />
Southerington. “But I ran for VAI because<br />
I knew I’d be helping bring hope to people<br />
who are fighting something much more<br />
difficult.”<br />
Did you know?<br />
In 2021, six athletes ran the<br />
New York City Marathon and<br />
11 ran the Chicago Marathon.<br />
Comparatively, in 2019 — the<br />
last year these races were held<br />
prior to COVID-19 pandemic<br />
restrictions — nearly 40 athletes<br />
ran these two marathons on<br />
behalf <strong>of</strong> VAI. We look forward to<br />
being back at it in full force for<br />
both races (and more) this year!<br />
Entries for the <strong>2022</strong> Berlin Marathon are sold out. To<br />
learn more about the VAI Marathon Team and how<br />
to join, visit vai.org/marathon-team/.<br />
28 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAI Student<br />
Ambassador Program<br />
making moves<br />
Van Andel Institute’s Student<br />
Ambassador Program serves as<br />
a tangible reminder <strong>of</strong> the power<br />
and passion exuded by the younger<br />
generations. Twenty-eight students<br />
came together virtually at the beginning<br />
<strong>of</strong> the 2021–22 school year to form the<br />
program’s third cohort. These bright,<br />
driven students meet once a month<br />
throughout the school year to connect<br />
with Institute scientists, educators and<br />
staff and learn how their efforts make a<br />
concrete difference to VAI’s work. They<br />
also meet with Institute staff to explore<br />
topics such as crafting a communications<br />
plan to support a fundraiser and how to<br />
pursue support from business sponsors.<br />
VAI Student Ambassadors combine<br />
everything they learn in the program<br />
to launch a fundraiser on behalf <strong>of</strong> the<br />
Institute, with 100% <strong>of</strong> proceeds going<br />
directly to our research and education<br />
programs. They also receive exclusive<br />
mentorship from the Institute’s heart and<br />
soul: Carol Van Andel, executive director<br />
<strong>of</strong> The David and Carol Van Andel Family<br />
Foundation and wife <strong>of</strong> VAI Chairman and<br />
CEO David Van Andel.<br />
Our current Student Ambassadors are hard<br />
at work on their culminating fundraiser —<br />
a movie night at Celebration Cinema on<br />
March 5 featuring the highly anticipated film<br />
“The Batman,” with the goal <strong>of</strong> selling out<br />
the 330-seat movie theater.<br />
To learn more about the Student Ambassador<br />
Program, or if you know someone who<br />
may be interested in applying, visit<br />
purplecommunity.org. Applications for the<br />
<strong>2022</strong>–23 school year will open May 1, <strong>2022</strong>.<br />
Upcoming Volunteer<br />
Opportunities<br />
Grand Rapids Griffins Purple Community Game<br />
(March 18)<br />
Volunteer C<strong>of</strong>fee and Catch Up<br />
(May 6 and Nov. 4)<br />
VAI Volunteer Celebration<br />
(Aug. 4)<br />
Weekly Volunteer Team<br />
(Wednesday mornings, 9–11 a.m.)<br />
Volunteer with VAI<br />
Van Andel Institute Purple Community<br />
is our grassroots fundraising program,<br />
bolstered by dedicated volunteers<br />
supporting VAI’s mission to improve<br />
health and enhance the lives <strong>of</strong> current<br />
and future generations.<br />
We have more than 50 active<br />
volunteers who support a variety <strong>of</strong><br />
VAI events each year that raise critical<br />
funds in support <strong>of</strong> the Institute’s<br />
groundbreaking research into diseases<br />
like cancer and Parkinson’s, as well as<br />
our science education programs.<br />
VAI Purple Community volunteers<br />
support the Institute for a multitude<br />
<strong>of</strong> reasons. Some have been<br />
personally impacted by the diseases<br />
our scientists study or have a friend<br />
or family member who has been<br />
affected. Others want to help foster<br />
and encourage the next generation<br />
<strong>of</strong> scientific minds, and Van Andel<br />
Institute for Education and Van Andel<br />
Institute Graduate School do just that!<br />
With an average <strong>of</strong> nearly 40<br />
community-led events per year, there<br />
are plenty <strong>of</strong> ways to get involved with<br />
VAI Purple Community, including:<br />
• Organizing and hosting an event<br />
• Volunteering at a VAI Purple<br />
Community event<br />
• Corporate partnerships<br />
• Becoming a VAI Student Ambassador<br />
To learn more about how you can get<br />
involved, visit purplecommunity.org or<br />
email purplecommunity@vai.org.<br />
Please note: Volunteer opportunities,<br />
especially for in-person events, are<br />
subject to change based on health and<br />
safety recommendations at the time <strong>of</strong><br />
the event.<br />
(AT LEFT) 2019 BANK OF AMERICA CHICAGO MARATHON<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 29
PHILANTHROPY<br />
Gifts in action:<br />
Funding new<br />
equipment to<br />
peer into cells<br />
Each gift to Van Andel Institute helps our scientists move another<br />
step closer to improving health and enhancing lives, especially with<br />
regard to diseases like cancer, Parkinson’s, and Alzheimer’s and related<br />
dementias. When these contributions come together in support <strong>of</strong> VAI’s<br />
work, their potential impact grows larger yet.<br />
In 2021, VAI received an incredible gift from the estate <strong>of</strong> the late Gasper<br />
“Gabe” Amodeo, a long-time supporter <strong>of</strong> our work who passed away in<br />
February 2021. Amodeo was diagnosed with Parkinson’s disease in the<br />
years prior to his passing, and he had a specific interest in supporting<br />
research into this insidious disease.<br />
Paired with a substantial gift from Richard and Paula Nelson — two<br />
dedicated supporters <strong>of</strong> VAI who have been personally touched by<br />
Parkinson’s disease through Richard’s own diagnosis — these funds have<br />
allowed VAI to purchase two ZEISS Axioscan 7 microscope slide scanners<br />
to be housed in the Institute’s Optical Imaging Core. These instruments<br />
will help facilitate the research <strong>of</strong> many VAI scientists and collaborators,<br />
including those focused on understanding the underpinnings <strong>of</strong><br />
Parkinson’s in the hopes <strong>of</strong> guiding the creation <strong>of</strong> new treatments for<br />
this disease and others like it. They are scheduled to be delivered and<br />
installed in March <strong>2022</strong>.<br />
VAI currently has a single ZEISS Axio Scan.Z1 — a previous version <strong>of</strong> the<br />
Axioscan 7 — that is utilized nearly 24 hours a day, seven days a week.<br />
The newest iteration <strong>of</strong> this technology digitizes specimens to create highquality,<br />
virtual microscope slides, and will be <strong>of</strong> great use to researchers<br />
in the Department <strong>of</strong> Neurodegenerative Science and throughout the<br />
Institute.<br />
Whether through new equipment or the support <strong>of</strong> a new study, the<br />
generosity <strong>of</strong> our donors powers research and education initiatives with<br />
the potential to change lives. Pairing gifts together allows VAI to make the<br />
biggest impact possible with donor funds.<br />
Remembering VAI in your estate plans helps ensure the Institute<br />
can continue its work to improve health and enhance lives for<br />
generations to come. For more information on ways to give,<br />
please contact Philanthropy Directors Kate Frillmann (kate.<br />
frillmann@vai.org) or Steve Ozinga (steve.ozinga@vai.org).<br />
30 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
(STARTING AT LEFT)<br />
GASPER “GABE” AMODEO;<br />
RICHARD & PAULA NELSON<br />
High-tech equipment at the Institute —<br />
including tools like the Leica microscope<br />
(pictured here) and the ZEISS Axioscan 7<br />
microscope slide scanners (funded in part by<br />
donor support) — enables VAI scientists to<br />
move their research further toward improving<br />
health and enhancing lives.<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 31
PHILANTHROPY<br />
MEMORIALS<br />
We appreciate your trust in us to fight disease in memory or in honor <strong>of</strong> your family and friends — with hope for a healthier tomorrow.<br />
To make a gift in memory or in honor <strong>of</strong> a loved one, please call 616.234.5392.<br />
Dominic Amante<br />
Scott & Audrey Olth<strong>of</strong><br />
Gasper J. Amodeo<br />
Catherine Amodeo<br />
Cindy Catalano<br />
Joseph & Marianne DiLorenzo<br />
The Grand Rapids Community<br />
Foundation<br />
Inglenook Condominium Association<br />
Patrick Leikert<br />
Daniel Veneklase<br />
William E. Anderson<br />
David & Ardith Robinson<br />
Allan L. Arnoys<br />
Joanne Arnoys<br />
Philip H. Battershall<br />
Martin & Susan Allen<br />
John Barrows<br />
Evie Bowers<br />
Joan Buchanan<br />
Gordon & Janice Bundy<br />
Martha Chalmers<br />
Diane Comfort<br />
David & Judith Devlin<br />
Marilyn Garter<br />
Shane & Ann Hansen<br />
Barnaby Jacob<br />
Jeffrey Koeze<br />
Madelaine Lane<br />
Gordon Lewis<br />
Rodney & Mimi Martin<br />
William & Ruselle Petchauer<br />
Frank & Lynette Spies<br />
Star Truck Rentals, Inc.<br />
Peter & Joan Steketee<br />
Jan Michel & Elisa ter Kuile<br />
David & Garnet Vanderleek<br />
William & Pat Waanders<br />
Warner<br />
Thomas Wisnom<br />
G. Thomas & Doris Worthington<br />
Raymond C. Becker<br />
James & Connie Becker<br />
Robert & Jane Boonstra<br />
Janice Buckley<br />
Roger & Karen Grinwis<br />
Lisa Locatis<br />
Philip & Marcia Mejeur<br />
Robert & Carolyn Walton<br />
Elizabeth Belson<br />
Lenora Lowe<br />
Nicole L. Beuschel<br />
Sue & James Baar<br />
Ernest C. Bevins<br />
David Bevins<br />
George W. Blasen<br />
Robert & Paula Hampson<br />
Thomas & Pamela Palmer<br />
Steven & Elizabeth<br />
Scharphorn<br />
Kathryn Thwaites<br />
Dale J. Bordewyk<br />
Shirley Bordewyk & family<br />
Robert L. Bradford<br />
Marvin & Ruth Bradford<br />
Patsy Jo Brinkert<br />
Kim Maurice<br />
Tom Brownell<br />
Tony Brownell<br />
Peter G. Bylsma<br />
Carol Bylsma<br />
Michael Calvaruso<br />
Jeffrey & Kelli Wynsma<br />
Richard A. Cebelak<br />
Mike & Sue Anderson<br />
Teresa Casey<br />
John & Nancy DeWildt<br />
Krin & Kevin Dreuth<br />
John & Mary Fix<br />
Paul & Carolyn Grady<br />
Pauline Jones<br />
Kellie & Kent Koth<br />
Ron & Kathy Mysliwiec<br />
Frank Palczewski<br />
Linda & Steven Parks<br />
John & Patricia Peters<br />
Marsha Potter<br />
Richard H Brown Foundation<br />
Norma J. Chapman<br />
Norma Chapman<br />
Roger Cook<br />
Roger & Judy Abbott<br />
Marilyn Cramer<br />
Helen & Ronald Van Farowe<br />
Lawrence DeSantis<br />
Kenneth & Arlynn Beimers<br />
Michelle Brainard & Julie O’Brien<br />
Ben & Gwen DeSantis<br />
Jon & Vicki Gardner<br />
Robert & Katie Kluting<br />
Ed & Susan Labanowski<br />
Christine & John Ritzenhein<br />
Kyle Rogers & Jerry Rogers<br />
Rodney Rothley & Mary Jensen<br />
Dave & Kimberly Shelton<br />
Darlene Snyder<br />
Kathleen Sparkman<br />
Anna Steinbrecher<br />
Jennifer Stevens<br />
Nate & Jeni Thomasma<br />
Sandra & Steve Vander Molen<br />
Todd Wawee<br />
Robert C. DuHadway<br />
Bill & Linda Peterson<br />
Ron Dykstra<br />
Christopher Chea<br />
Melissa A. Eden<br />
Keith & Carolyn Murphy<br />
John S. Edison<br />
Edith Vasu<br />
Carla Fail<br />
Andrew Hoeksema<br />
Patsy R. Ferrell<br />
Gretchen & Michael LaBell<br />
Joyce A. Fortier<br />
Jacqueline Kozal<br />
William R. Foster<br />
John Marshall<br />
Susan Freyer<br />
Jonathan & Julie Freyer<br />
Gerald Goeldel<br />
Kim Maurice<br />
Betty & Richard Goodenough<br />
Frieda Jaynes<br />
Marjorie R. Haan<br />
Jacqueline Kozal<br />
Carol A. Haarman<br />
Stephen Haarman<br />
James F. Hass<br />
Richard Hillman & Barbara<br />
Burby Hillman<br />
Olivia Haverkamp<br />
Derek Jacobsen<br />
Billie M. Janer<br />
Andrew & Courtney Kolanowski<br />
32 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
Gisela Kah<br />
Greg Northrup & Birgit Klohs<br />
Mark L. Kastner<br />
Brenda Kastner<br />
Nathanael Kastner<br />
John R. Kendall<br />
Carole DuHadway<br />
Min Ja Kim<br />
Dr. Chung Yul Kim<br />
Leah E. Koldenhoven<br />
David & Carol Van Andel<br />
Family Foundation<br />
James M. Kozal<br />
Jacqueline Kozal<br />
Steven Kruith<strong>of</strong>f<br />
Edward & Karen Bezilla<br />
Joann Lehman<br />
Bernie Lehman<br />
MaryKay Lehman<br />
Laura Miersen<br />
Gertrude A. L<strong>of</strong>gren<br />
Kim Maurice<br />
Michelle Marie Lunn<br />
Michelle Lunn <strong>Hope</strong> Foundation<br />
Donald W. Maine<br />
Kenneth & Jill Peirce<br />
William R. McCallister<br />
Kathryn & Richard Hansen<br />
Robert H. McDowell<br />
Richard Hillman & Barbara<br />
Burby Hillman<br />
Sandra McNeil<br />
Joyce Snow<br />
Eleanor Medendorp<br />
Mark & Mary Fletcher<br />
Jack & Marcy Medendorp<br />
Randall L. Meredith<br />
Donna & Ervin Miller<br />
Mary H. Milidonis<br />
Mike Everett<br />
Richard L. Miller<br />
Paul & Mary Jane Jackman<br />
Micheline Jura<br />
Caroline Stacy<br />
Claudette Wandt<br />
Barb & Gary Woodhull<br />
Verne Miller<br />
Jacqueline Kozal<br />
Betty Ann Morin<br />
J. Brooks<br />
Jane Nichols<br />
John Nichols<br />
Robert D. Oberto<br />
Carole DuHadway<br />
Gregory D. Olson<br />
J. Brooks<br />
Angela N. Pasteur<br />
David & Carol Van Andel<br />
Family Foundation<br />
Patty Peck<br />
Theresa Kettlewell<br />
Thomas M. Peck<br />
Susan Van Dellen<br />
Denise Picardat<br />
Brian Picardat<br />
Valerie J. Poppema<br />
Mike & Lieschen Jacobs<br />
Cindy Keson<br />
Richard L. Pullen<br />
Ruth Kemp<br />
Neda L. Raterink<br />
Gary Raterink<br />
Rosie Ridder<br />
Dawn & Shawn Walton<br />
Harvey Ringerwole<br />
Timothy Sanders<br />
Nicole A. Robach<br />
West Michigan Tag & Label, Inc.<br />
Ellen K. Roberts<br />
Florence Benson<br />
Gerald & Betty Hecht<br />
Eileen McKenna<br />
James Kilduff & Shannon<br />
Neumann Kilduff<br />
Mel & Mary Pasch<br />
Robert & Judy Plumer<br />
Lucy Roberts<br />
Douglas & Tina Rudd<br />
Austin & Miriam Zimmerman<br />
Daniel T. Robinson<br />
Anonymous<br />
Richard D. Roetman<br />
David & Sallie Brinks<br />
Ken A. Ross<br />
Margaret Fondren<br />
David L. Rossi<br />
Anne Rossi<br />
Fred R. Rozema<br />
James & Jeri Kett<br />
Roger & Susan Levering<br />
The Rozema Family Fund<br />
James R. Schenden<br />
Pamela Allen<br />
Donald & Marilyn Cory<br />
James & Becki Hansen<br />
Randy & Linda Lincoln<br />
Luce Plumbing, LLC<br />
Joanne Schenden<br />
Kirk & Cindy Warner<br />
James R. Schmalz<br />
Leslie Schmalz<br />
Teri Sivertson<br />
Martha Elias<br />
Robyn R. Sorrell<br />
Kim Maurice<br />
Heather Sturr<br />
Eric Sturr<br />
Randall S. Sullivan<br />
Ryan Bassett<br />
Mark Bryan & Juan Carlos<br />
Carretero<br />
Larry & Edith Young<br />
Susan L. Suwyn<br />
Dale & Susan Prins<br />
Morris W. Symon<br />
Rick & Willow Chapla<br />
Marilyn Van Portfliet<br />
David & Carol Van Andel<br />
Family Foundation<br />
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 33
PHILANTHROPY<br />
MEMORIALS (continued)<br />
Dr. George F. Vande Woude<br />
David & Susan Birdsall<br />
David & Carol Van Andel<br />
Family Foundation<br />
James & Gail Fahner<br />
David Garfinkel & Janet<br />
Westpheling & John Hibbard<br />
Dr. Anthony Hunter<br />
Emily Knowles Kellett<br />
Eun Mi Koo<br />
Michigan State University<br />
College <strong>of</strong> Human Medicine<br />
Michael & Pamela Murray<br />
Ann Schoen<br />
Bill VanDenBerge<br />
Connor & Mallory Millar<br />
Steven R. VandenBrink<br />
Kim Maurice<br />
Elizabeth F. VanderJagt<br />
Grandville Bible Church<br />
Lake Michigan Dental<br />
Lois Mol<br />
Casey Tjalsma<br />
Steven Vanderjagt<br />
William J. VanRegenmorter<br />
William & Rosemary Stevenson<br />
Katherine A. Veldink<br />
Kim Maurice<br />
Nina C. Veneklase<br />
Catherine Amodeo<br />
Rebecca M. Vogelsang<br />
Stephen & Jennifer Czech<br />
Katelyn M. Wallace<br />
Walter & Nina Gorak<br />
Maryrita Weiss<br />
Thomas & Susan Swaney<br />
Eric Westra<br />
Hilary Hoekwater<br />
David Wiersema<br />
Kilwins<br />
Carol L. Winton<br />
Dave & Jody Lockwood<br />
Nicole A. Wyble<br />
Joseph & Sara Robach<br />
Dan Young<br />
Joseph & Kelley Young<br />
William R. Zoller<br />
Mark Miller<br />
Maria Van Til<br />
Bill Zollverein<br />
Merrill Lynch, Pierce, Fenner<br />
& Smith Inc.<br />
Charles Zwiers<br />
David & Carol Van Andel<br />
Family Foundation<br />
TRIBUTES<br />
Darrin Batdorff<br />
Grandville Middle School<br />
Raymond Becker<br />
Priscilla Becker<br />
Liz Sadlowski Burns<br />
Jonathan & Beth Mast<br />
Rachel Ducat<br />
Michelle & Brian Retzler<br />
Pauline Flaga<br />
Cathy & Mike Flaga<br />
Lee W. Formwalt<br />
Sanders Foundation<br />
Tom Halstead<br />
Eugene & Barbara Gutting<br />
David H. Kammeraad<br />
Richard Spruit & Marisa Fahnenstiel<br />
Sandy Kelly<br />
Lesley Goebel<br />
Matthew Kirkwood<br />
Kristen Mahoney<br />
Belinda Klein<br />
Cassandra & Brandon Zeivel<br />
Kathleen P. Maine<br />
Kenneth & Jill Peirce<br />
David M. Munn<br />
Ann & Herbert Alvarado<br />
Olivia Nino<br />
Esperanza Watt<br />
Kenneth & Jill Peirce<br />
M. Rodrick & Kathleen Bolhous<br />
Ronald K. Rutkowski<br />
Nancy & Leonard Fouty<br />
Steve Sanxter<br />
Meghan Sanxter<br />
Ruth Secor<br />
Steve Secor<br />
Nikki Stevenson Serrano<br />
Toni Sadlowski<br />
Louie Stein<br />
Carolyn Stein<br />
Todd Stevens<br />
Kathleen Teunis<br />
David & Carol Van Andel<br />
Mike & Lynette Ellis<br />
James & Gail Fahner<br />
Judy VanEk<br />
Beth Andringa<br />
Char Veenstra<br />
Karen & Brian Meidema<br />
Richard Vokes<br />
Carolyn Stein<br />
Dona Whitehouse<br />
Greg Northrup & Birgit Klohs<br />
Karen Zylstra<br />
Grandville Middle School<br />
Graham Hoekstra<br />
Sara & Scott Pedersen<br />
Ashley K. Owen<br />
Sheldon & Emma Weiss<br />
Brian Toronyi<br />
Susan Toronyi<br />
These lists represent gifts made between Jan. 1, 2021, and Dec. 31, 2021. The accuracy <strong>of</strong> these lists is very important to us. Please contact 616.234.5392 if an error has been made.<br />
34 | VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE
VAN ANDEL INSTITUTE HIGHLIGHTS OF HOPE | 35
Van Andel Institute<br />
represents a family<br />
legacy. Founded by<br />
Join the Jay and Betty Van Andel<br />
Circle <strong>of</strong> <strong>Hope</strong><br />
A significant and growing number <strong>of</strong> individuals and households have<br />
remembered VAI in their estate plans. These planned giving intentions<br />
will greatly benefit the Institute’s research into diseases like cancer,<br />
Parkinson’s, and Alzheimer’s and related dementias, as well as our work<br />
to educate the next generation <strong>of</strong> scientific leaders and foster curiosity,<br />
creativity and critical thinking in K–12 classrooms.<br />
Jay and Betty<br />
Van Andel, that<br />
VAI honors those who have included the Institute in their estate plans<br />
through the Jay and Betty Van Andel Circle <strong>of</strong> <strong>Hope</strong>. When you notify<br />
us <strong>of</strong> your intentions, you are invited to become a member. More<br />
information about the benefits <strong>of</strong> membership can be found at<br />
vai.org/plannedgiving.<br />
legacy is now<br />
carried forward by<br />
Chairman and CEO<br />
David Van Andel<br />
and his wife, Carol.<br />
We welcome a conversation about estate giving that<br />
makes the most sense for you while also supporting<br />
the mission <strong>of</strong> VAI. Additional information about<br />
estate giving can be found at vai.giftlegacy.com.<br />
Please contact:<br />
Kate Frillmann, Philanthropy Director<br />
616.234.5515<br />
Kate.Frillmann@vai.org<br />
Steve Ozinga, Philanthropy Director<br />
616.234.5040<br />
Steve.Ozinga@vai.org<br />
JAY VAN ANDEL<br />
BETTY VAN ANDEL