final Program - Neurorepair 2012

7th International Symposium on 

THE magDEBUrg mEETing SEriES 

may 2–5, 2012 | Potsdam, germany 

final 

Program

Matching the Power 

of Stem Cells 

Active Matching for Single 

and Multiple Stem Cells 

Cytolon AG 

Am Karlsbad 15 

10785 Berlin - Germany 

Web Interface for Dialogue 

and Processing between 

all High End-Users 

Contact the Makers of CordMatch ® 

phone: +49 (0) 30 2639 2880 

e-mail: info@cytolon.com 

web: www.cytolon.com 

Or register directly at www.cordmatch.org

Main Sponsors 

supported by 

7 th InternatIonal SympoSIum 

on neuroprotectIon and neurorepaIr 2012 



may 2–5, 2012 | Potsdam, germany 

| 3

general InformatIon 

4 | 

Instruments that are music to your hands. 

FINE SURGI CAL INSTRUME N T S FOR RESEARC H 

SHIPPING GLOBALLY SINCE 1974 

Request a catalog at finescience.de or call +49 (0) 62 21 – 90 . 

50 50

ConTEnT 



Welcome _______________________________________________________________________ 7 

General Information _____________________________________________________________ 8–9 

Program Overview ____________________________________________________________ 10–11 

Program May 2, 2012 __________________________________________________________ 12–14 




Poster Exhibition _____________________________________________________________ 26–35 

Scholarship ____________________________________________________________________ 36 

Exhibition/ Sponsors __________________________________________________________ 38–39 

Evening Functions ____________________________________________________________ 40–42 

| 5


Discover the Leading 

Quantitative Tools 

in Neuroscience Research 

At MBF, we are dedicated to providing you with the most comprehensive 

microscopy image analysis solutions and the best support in the industry. 

We invite you to view our latest product offerings, recently updated to provide 

even more of the research tools your lab requires. 

Neurolucida ® 

for Neuroanatomical Analysis 

Stereo Investigator ® 

for Unbiased Stereology 

AutoNeuron ® 

for Automated Neuron Tracing 

Densita ® 

for Autoradiography 

web www.mbfbioscience.com 

email info@mbfbioscience.com 

phone +49 (0)391 732 6989 

Virtual Slice ® 

for Full-Slide Imaging 

MicroBrightfield Europe e.K. 

Providing trusted solutions to neuroscience researchers for more than 22 years 

6 |

DEar CollEagUES anD friEnDS, 



We are delighted to welcome more than 300 colleagues from 29 countries and 5 continents who joined us for 

the 7th International Symposium on Neuroprotection & Neurorepair. Thank you for making it the so far largest 

meeting of the renowned and successful Magdeburg Meeting Series. 

We come together in the Prussian residential city of Potsdam, being situated at the gates of Berlin, and 

housing some of the most important historical sites. Among them are Sanssouci, the former summer palace of 

Frederick the Great, King of Prussia, and Cecilienhof, the location of the Potsdam Conference immediately after 

World War II. For sure Potsdam looks back to a turbulent and rich history, but has always been a place of international 

atmosphere. Particularly, from the ground we are standing on, the mighty and elegant Zeppelin airships 

departed to connect people from different countries and continents in time when the idea of global travelling by 

fast jet airplanes was still nothing more than a utopian dream. 

Now, the city brings together researchers, colleagues and friends from all over the world to discuss the 

latest research findings. We are going to report results from ongoing endeavors regarding the clinical translation 

of thoroughly conducted research that hopefully will provide additional benefit to our patients. We will also 

discuss strategies for targeted neuroregeneration and rehabilitation, for enhanced diagnosis and visualization 

by novel imaging approaches as well as cell based therapies. A major, but not the sole focus will be given to the 

ageing brain as well as vascular aspects of neurodegeneration and dementia. We will also try to find novel and 

innovative ways to balance immune responses to central nervous system damage and to address metabolic and 

neurochemical processes as targets for neuroprotection and neurorepair. 

Most importantly, the unique and special philosophy of the meeting series, its scientific spirit, has always 

been the fusion of scientific excellence in exciting talks with the opportunity for ample time for fruitful 

discussions and exchange of ideas. The attendance of leading experts from internationally renowned scientific 

institutes initiates a straightforward and rewarding scientific debate which will be joined by the contributions of 

the younger colleagues. Moreover, we will have opportunities to refresh old friendships, as well as to make new 

ones during the carefully organized social program in well selected places. 

Finally, we want to thank all those who provided continuous support and helped us in making the 7th 

International Symposium on Neuroprotection and Neurorepair possible. We especially thank our sponsors from 

the industry for generous support and scientific contributions. Without this support, it would have been impossible 

to organize the meeting and to keep registration fees as low. Moreover, we would not be able to attract so 

many distinguished speakers without the support of the German Research Foundation (Deutsche Forschungsgemeinschaft, 

DFG) and the German Federal Ministry of Education and Research (Bundesministerium für Bildung 

und Forschung, BMBF). We also are grateful for the International Society on Neurochemistry (ISN) as well as the 

International Brain Research Organization (IBRO) which provided major support in form of scholarships for those 

young colleagues, who submitted excellent contributions, but still lack own travel budgets. 

We are now looking forward to four amazing days filled with cutting edge research, as well as stimulating 

scientific discussions which hopefully will provide you with even more fresh ideas for your further research 

endeavors. 

Sincerely yours, 

Klaus Reymann Georg Reiser Johannes Boltze Alexander Kranz Daniel-Christoph Wagner 

| 7


ConfErEnCE CoorDinaTorS 

fraunhofer institute for Cell Therapy and immunology 

Johannes Boltze, Alexander Kranz, Daniel-Christoph Wagner 

Perlickstr. 1, 04103 Leipzig 

otto-von-guericke-Universität magdeburg 

medizinische fakultät 

institut für neurobiochemie 

Georg Reiser 

Leipziger Str. 44, 39120 Magdeburg 

leibniz institute for neurobiology 

Klaus Reymann 

Brenneckestrasse 6, 39118 Magdeburg 

ConfErEnCE offiCE 

event lab. GmbH 

Dufourstrasse 15 on Site 

04107 Leipzig Phone: +49 (0) 177 2807770 

ConfErEnCE DaTES | oPEning HoUrS rEgiSTraTion DESk 

Wednesday, May 2, 2012 12:00 am – 08:30 pm 

Thursday, May 3, 2012 08:00 am – 08:00 pm 

Friday, May 4, 2012 08:00 am – 06:30 pm 

Saturday, May 5, 2012 08:00 am – 01:00 pm 

SPEakErS’ PrEviEw 

The speakers’ preview room, room 0-215, will be open at all times during the conference. Please come 

to the speakers’ preview room as soon as possible and no later than 2 hours before your session starts. 

Presentations will be delivered to the lecture hall. 

langUagE 

The official language of the symposium is English. There will be no translations. 

ParTiCiPaTion | namE TagS 

Official conference name tags will be required for admission to all conference functions, scientific sessions 

and exhibition areas. Participants who lose their name tags will have to pay a fee of 25,00 EUR to obtain a 

replacement tag. 

8 |

inTErnET 

Tickets for w-lan can be purchased at the hotel lobby per day. 



ExHiBiTion informaTion 

The exhibition will be located in the foyer area. The exhibition will be open as follows: 

Wednesday, May 2, 2012 01:00 pm – 10:00 pm 

Thursday, May 3, 2012 08:00 am – 08:00 pm 

Friday, May 4, 2012 08:00 am – 06:30 pm 

PoSTEr SESSionS 

Session I Thursday, May 3, 2012 01:00 pm – 02:00 pm 

Session II Thursday, May 3, 2012 01:00 pm – 02:00 pm 

Session III Friday, May 4, 2012 12:30 pm – 01:30 pm 

Session IV Friday, May 4, 2012 12:30 pm – 01:30 pm 

The poster exhibition will take place in the foyer area. 

mounting and dismounting of posters 

The poster boards will be marked with numbers referring to those stated in the program and on the abstract 

CD. Materials for mounting the posters will be provided. Posters will be on display during the whole 

conference. During the poster sessions times indicated above the presenting author should be ready to 

answer questions. Make sure to remove your poster before Saturday, May 5, 1:00 pm. Meeting organizers 

cannot take responsibility for material still displaced beyond that time. 

PoSTEr awarDS 

pluriSelect GmbH announced a 300,00 EUR poster prize including a ticket for the evening function and two 

cell separation kits from pluriSelect for the best PhD – poster displayed on the 7th International Symposium 

on Neuroprotection and Neurorepair. 

Please contact the plusiSelect staff at their stand that you are interested in winning the poster price. 

ASN NEURO announced a 300,00 EUR poster prize for the best-ranked poster abstract on the 7th International 

Symposium on Neuroprotection and Neurorepair. 

The poster prices will be awarded at the closing ceremony. 

CErTifiCaTion 

The Medical Association of Brandenburg certificates the meeting with 18 continuing education points. 

Certificates will be issued at the registration desk. 

| 9

Program ovErviEw 

08:00 am 

10 | 

wEDnESDay, may 2 THUrSDay, may 3 

main lECTUrE Hall foyEr main lECTUrE Hall foyEr 

08:30 am Imaging and Novel 

Diagnostics I 

09:00 am 

09:30 am 

10:00 am Coffee break 

10:30 am Vascular Aspects of 

Neurodegeneration 

11:00 am 

11:30 am 

12:00 am 12:15 pm 

Lunch break 

12:30 pm 12:30 pm 

Lunch Symposium Cytolon 

01:00 pm Opening Ceremony Room 0-214 

Poster sessions 

I + II 

01:30 pm 01:15 pm Presidential Lecture 

02:00 pm Hot News on Therapeutic Transla- 

Imaging and Novel 

tions – The Industrial Perspective 

Diagnostics II 

02:30 pm 02:40 pm 

Coffee break 

03:00 pm Balancing Immune Responses in 

Free Communications – 

Neurodegeneration 

Clinical Perspectives 

03:30 pm Neurodegeneration in Stroke, 

Alzheimer Dementia and 

04:00 pm 

Ageing I 

04:30 pm 04:40 pm 

Coffee break 

05:00 pm 

05:30 pm 05:20 pm 

Coffee break 

06:00 pm Best-ranked Abstracts 

Neurodegeneration in Stroke, 

Alzheimer Dementia and 

Ageing II 

06:30 pm Refreshment break 

07:00 pm Plenary Session and Podium 

Discussion 

07:30 pm Hot News on Therapeutic 

Translations – The Academic 

08:00 pm Perspective 

BBQ at the garden of the Kongresshotel 

08:30 pm Get together in the exhibition area

08:00 am 



friDay, may 4 SaTUrDay, may 5 

08:30 am The Janus Face of Reactive 

Astrogliosis 

09:00 am 

09:30 am 

main lECTUrE Hall foyEr main lECTUrE Hall foyEr 

Stem Cell Therapies 

10:00 am Coffee break Coffee break 

10:30 am Mitochondria as Cellular 

Targets for Neuroprotection I 

11:00 am 

Free Communications – 

Stem Cells 

11:30 am Supporting Lesioned and Aging 

Brains – Future Perspectives 

12:00 am 11:45 am 

Lunch break 

12:30 pm 

01:00 pm 

Poster sessions 

III + IV 

Closing session 

01:30 pm Mitochondria as Cellular 

Targets for Neuroprotection II 

02:00 pm 

02:30 pm Neuroregeneration, Plasticity 

and Rehabilitation I 

03:00 pm 

03:30 pm 

04:00 pm 

04:30 pm Coffee break 

05:00 pm Neuroregeneration, Plasticity 

and Rehabilitation II 

05:30 pm 

06:00 pm What Embryogenesis can teach 

us about Regeneration 

06:30 pm 

07:00 pm 

07:30 pm 

08:00 pm Social evening at the Biosphäre Potsdam 

| 11

SCiEnTifiC Program 

wEDnESDay, may 2, 2012 

main lecture hall 

1:00 – 1:15 Pm oPEning CErEmony 

12 | 

Reiser G., Reymann K., Boltze J. 

welcome address 

1:15 – 2:00 Pm PrESiDEnTial lECTUrE 

Chair: Reymann K. 

Baron J.-C. (Cambridge, UK) INVITED 

neuroprotection and neural repair after ischemic stroke: Pathophysiological 

insights from imaging in the clinical and experimental setting 

2:00 – 2:40 Pm HoT nEwS on THEraPEUTiC TranSlaTionS – THE inDUSTrial PErSPECTivE 

Chairs: Kleinschnitz C., Boltze J. 

2:00 – 2:20 PM Zahavi-Goldstein E. (Haifa, Israel) 

kindly supported by Pluristem Therapeutics Inc. 

3D cultured placental derived mSC-like cells for cell therapy – 

from the lab into the clinic 

2:20 – 2:40 PM Schliehe-Diecks R. (Berlin, Germany) 

kindly supported by Cytolon AG 

Hla-matching of non-autologous (stem) cell preparations – 

introduction of a novel search engine for time-critical cell therapies 

2:40 – 3:00 PM Coffee break, Exhibition area 

3:00 – 5:20 Pm BalanCing immUnE rESPonSES in nEUroDEgEnEraTion i 

kindly supported by Novartis Pharma GmbH 

Chairs: del Zoppo G., Reymann K. 

3:00 – 3:30 PM del Zoppo G. (Seattle, USA) INVITED 

Barrier function in the neurovascular unit: acute Pmn leukocyte trafficking and 

innate inflammation 

3:30 – 3:50 PM Iadecola C. (New York, USA) INVITED 

innate immunity, oxidative stress and beta-amyloid pathobiology: implications 

for neurodegeneration 

3:50 – 4:10 PM Engelhardt B. (Bern, Switzerland) INVITED 

Challenging the dogma of neutrophil invasion into the brain after ischemic stroke



4:10 – 4:30 PM Veltkamp R. (Heidelberg, Germany) INVITED 

T-cells after cerebral ischemia – protective versus deleterious mechanisms 

4:30 – 4:50 PM Kleinschnitz C. (Würzburg, Germany) 

The unexpected role of regulatory T-cells in ischemic stroke 

4:50 – 5:05 PM Low P.-C. (Brisbane, Australia) 

inhibition of phosphoinositide 3-kinase delta reduces reperfusion-induced 

inflammation in ischemic stroke 

5:05 – 5:20 PM Neumann J. (Magdeburg, Gemany) 

Taking neutrophils out of play in developing secondary neuronal damage after 

stroke by anti-vla-4 treatment? 


6:00 – 7:30 Pm BEST-rankED aBSTraCTS 

Chairs: Veltkamp R., Iadecola C. 

6:00 – 6:15 PM Bach A. (Copenhagen, Denmark) 

a high-affinity, dimeric inhibitor of PSD-95 protects against ischemic brain damage 

6:15 – 6:30 PM Bix G. (College Station, USA) 

Perlecan domain v promotes post-stroke neuroregeneration in transient and 

permanent ischemic stroke models 

6:30 – 6:45 PM Clarkson A. (Dunedin, New Zealand) 

modulating post-stroke tonic inhibition offers an extended therapeutic window 

for facilitating functional improvements 

6:45 – 7:00 PM Orsini F. (Milano, Italy) 

role of mannose binding lectin in ischemic injury 

7:00 – 7:15 PM Lykke-Hartmann K. (Aarhus, Denmark) 

assessing roles of aTP1α2 in familiar Hemiplegic migraine type 2 (fHm2) 

7:15 – 7:30 PM Freed W. (Baltimore, USA) 

alterations in the differentiation capacity of human embryonic stem cells 

associated with chromosome 17 copy number variations 

| 13



7:30 – 8:30 Pm HoT nEwS on THEraPEUTiC TranSlaTionS – THE aCaDEmiC PErSPECTivE 

14 | 

Chairs: Kleinschnitz C., Boltze J. 

7:30 – 7:50 PM Schäbitz W.-R. (Bielefeld, Germany) INVITED 

is neuroprotection for stroke treatment a realistic therapeutic target? lessons 

learned from the axiS ii trial. 

7:50 – 8:10 PM Savitz S. I. (Houston, USA) INVITED 

Bone marrow mononuclear cells for stroke treatment 

8:10 – 8:30 PM Steinberg G. (Stanford, USA) INVITED 

Human neural stem cell therapy for stroke: mechanisms underlying recovery 

and translation into the clinic. 

8:30 – 10:30 Pm gET TogETHEr in THE ExHiBiTion arEa

For some things in life 

there will never be an app. 

The new Boxster. 



Please visit www.porsche.com for further information. 

Fuel consumption in l/100 km (mpg) urban 12.2 (23.2)–10.6 (26.6) · extra urban 6.9 (40.9)–5.9 (47.9) 

combined 8.8 (32.1)–7.7 (36.7); C0 2 emissions 206–180 g/km 

| 15


THUrSDay, may 3, 2012 


8:30 – 10:00 am imaging anD novEl DiagnoSTiCS i 

16 | 

Chairs: Koretsky A., Barthel H. 

8:30 – 8:50 AM Koretsky A. (Bethesda, USA) INVITED 

Single vessel fmri in rat Somatosensory Cortex 

8:50 – 9:10 AM Dijkhuizen R. (Utrecht, Netherland) INVITED 

mr imaging of large-scale brain reorganization in relation to functional 

recovery after experimental stroke 

9:10 – 9:30 AM Barthel H. (Leipzig, Germany) INVITED 

Beta-amyloid PET imaging of dementia and dementia therapies 

9:30 – 9:45 AM Klohs J. (Zurich, Switzerland) 

Contrast-Enhanced magnetic resonance microangiography reveals remodeling of 

the cerebral microvasculature in transgenic arcabeta mice 

9:45 – 10:00 AM Fuchs D. (Toronto, Canada) 

kindly supported by VisualSonics 

in vivo imaging for neuroscience preclinical research: latest updates 

in angiogenesis, blood flow, hypoxia and nanoparticle research 

10:00 – 10:30 AM Coffee break, Exhibition area 

10:30 am – vaSCUlar aSPECTS of nEUroDEgEnEraTion 

12:15 Pm 

Chairs: Sironi L., Reymann K. 

10:30 – 11:00 AM Zlokovic B. (Rochester, USA) INVITED 

neurovascular mechanisms of neurodegeneration 

11:00 – 11:20 AM Nishimura N. (Ithaca, USA) INVITED 

Capillary plugging by leukocytes contributes to blood flow reduction in mouse 

models of alzheimer‘s disease 

11:20 – 11:40 AM Kim J. S. (Seoul, Korea) INVITED 

neuroprotective effects of phophodiesterase inhibitors 

11:40 AM – 12:00 PM Sironi L. (Milano, Italy) INVITED 

neurodegeneration and neurorepair in animal models of brain ischemic diseases: 

focus on the gPr17 receptor



12:00 – 12:15 PM Michalski D. (Leipzig, Germany) 

Tissue plasminogen activator-associated blood-brain barrier alterations are not 

inhibited by co-administered hyperbaric oxygen after experimental thromboembolic 

stroke 

12:15 – 1:00 PM Lunch break 

room 0-214 

12:30 – 1:45 Pm lUnCH SymPoSiUm CyTolon 

exhibition area 

1:00 – 2:00 Pm PoSTEr SESSionS i + ii 


2:00 – 3:00 Pm imaging anD novEl DiagnoSTiCS ii 

Chairs: Dijkhuizen R., Kranz A. 

2:00 – 2:20 PM Kozberg M. (New York, USA) 

novel in vivo imaging techniques for studying the neurovascular unit 

2:20 – 2:40 PM Fisher M. (Worcester, USA) INVITED 

Penumbral imaging for enhanced selection of patients likely to respond 

to acute therapy 

2:40 – 3:00 PM Stoll G. (Würzburg, Germany) INVITED 

mr-imaging of blood brain barrier dysfunction and neuroinflammation 

3:00 – 3:30 Pm frEE CommUniCaTionS – CliniCal PErSPECTivES 

Chairs: Reiser G., Boltze J. 

3:00 – 3:15 PM Blondeau N. (Valbonne, France) 

a new future in brain preconditioning based on nutraceuticals: 

a focus on α-linolenic ω-3 fatty acid for stroke protection. 

3:15 – 3:30 PM Dihné M. (Tübingen, Germany) 

Cerebrospinal fluid-diagnostics on functional neuronal networks: 

a new tool in neurology? 

| 17




3:30 – 4:40 Pm nEUroDEgEnEraTion in STrokE, alzHEimEr DEmEnTia anD agEing i 

18 | 

Chairs: Demuth H.-U., Reiser G. 

3:30 – 4:00 PM Pinteaux E. (Manchester, UK) INVITED 

The role of inflammation during acute brain injury and repair 

4:00 – 4:20 PM Braun H. (Magdeburg, Germany) INVITED 

The cerebral small vessel disease-new insights from the SHSP rat 

4:20 – 4:40 PM Feinstein D. (Chicago, USA) INVITED 

The potential use of PParγ-sparing TzDs for treatment of neurodegenerative diseases 


5:20 – 6:30 Pm nEUroDEgEnEraTion in STrokE, alzHEimEr DEmEnTia anD agEing ii 

Chairs: Demuth H.-U., Baron J.-C. 

5:20 – 5:40 PM Badaut J. (Loma Linda, USA) INVITED 

Does accelerated aging of the blood-brain barrier promote cognitive decline after 

Juvenile brain injury? 

5:40 – 6:00 PM Demuth H.-U. (Halle, Germany) 

inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation 

in alzheimer‘s disease 

6:00 – 6:15 PM Nagata K. (Akita, Japan) 

Preservation of muscarinic acetyl choline receptors in patients with alzheimer‘s 

disease and vascular dementia 

6:15 – 6:30 PM Rossner S. (Leipzig, Germany) 

Diverse cellular mechanisms contribute to hippocampal n-Pyroglutamate-abeta 

deposition 

6:30 – 7:00 PM Refreshment break 

7:00 – 8:00 Pm PlEnary SESSion anD PoDiUm DiSCUSSion 

Chairs: Reymann K., Zlokovic B. 

7:00 – 7:20 PM Leys D. (Lille, France) INVITED 

Stroke and Dementia – two consequences of a diseased vasculature 

7:20 – 8:00 PM Discussion 

8:00 – 10:00 Pm BarBECUE aT THE garDEn of THE kongrESSHoTEl

Get more from 

your experiments 

Discover more at abcam.com/neuroprotection 



A comprehensive range of tools for the study 

of neurodegenerative diseases and more. 

Don’t let your research into neurodegenerative diseases hit a dead 

end. Try our range of: 

• IHC-validated polyclonal and monoclonal primary antibodies 

• Pre-adsorbed secondaries 

• Neurotransmitter receptor agonists and antagonists 

And drive your experiments forward. 

| 19


friDay, may 4, 2012 


8:30 – 10:00 am THE JanUS faCE of rEaCTivE aSTroglioSiS 

20 | 

Chairs: Sofroniew M., Pekny M. 

8:30 – 9:00 AM Sofroniew M. (Los Angeles, USA) INVITED 

astrocyte biology and pathology: Evidence for roles in non-cell-autonomous 

neurodegeneration and neuroprotection 

9:00 – 9:20 AM Götz M. (Munich, Germany) INVITED 

neurogenesis from glial cells – from neural stem cells to reactive gliosis 

9:20 – 9:40 AM Pekny M. (Gothenburg, Sweden) INVITED 

Two sides of reactive gliosis – from cell biology to therapeutic opportunities 

9:40 – 10:00 AM Ruscher K. (Lund, Sweden) 

Dopamine signaling in astrocytes – relevance for levodopa induced 

recovery after stroke 


10:30 – 11:45 am miToCHonDria aS CEllUlar TargETS for nEUroProTECTion i 

Chairs: Reiser G., Culmsee C. 

10:30 – 10:50 AM Reiser G. (Magdeburg, Germany) INVITED 

Two principles for neuroprotection: mitochondria with the permeability 

transition, and the activated protein C (aPC)/EPCr signaling system 

10:50 – 11:05 AM Dolga A. (Marburg, Germany) 

Small conductance Sk2/kCa2.2 channels in mitochondria as novel targets for 

neuroprotection 

11:05 – 11:25 AM Pahnke J. (Magdeburg, Germany) INVITED 

mitochondria and aBC transporter mechanisms 

11:25 – 11:45 AM Heneka M. (Bonn, Germany) INVITED 

PParγ as a mediator of nSaiD protection in alzheimer 

11:45 AM – 12:30 PM Lunch break

exhibition area 

12:30 – 1:30 Pm PoSTEr SESSionS iii + iv 




1:30 – 2:30 Pm miToCHonDria aS CEllUlar TargETS for nEUroProTECTion ii 

Chairs: Reiser G., Culmsee C. 

1:30 – 1:50 PM Vemuganti R. (Madison, USA) INVITED 

Ubiquitin-like protein modifications are neuroprotective after stroke 

1:50 – 2:10 PM Murphy A. (La Jolla, USA) INVITED 

mitochondria as targets of thiazolidinediones, and the value of preclinical 

systematic review 

2:10 – 2:30 PM Plesnila N. (Munich, Germany) 

mitochondrial cell death signaling in ischemic stroke 

2:30 – 4:30 Pm nEUrorEgEnEraTion, PlaSTiCiTy anD rEHaBiliTaTion i 

Chairs: Düzel E., Nudo R. 

2:30 – 3:00 PM Carmichael T. (Los Angeles, USA) INVITED 

age-related neuronal growth program during recovery from stroke 

3:00 – 3:20 PM Pluchino S. (Cambridge, UK) INVITED 

Secreted ncrnas and neural stem cell therapeutic plasticity 

3:20 – 3:40 PM Villringer A. (Leipzig, Germany) INVITED 

Procedural learning and associated brain plasticity 

3:40 – 4:00 PM Witte O. (Jena, Germany) INVITED 

lesion- and age-dependent impairment of brain plasticity: Therapeutic options? 

4:00 – 4:15 PM Popa-Wagner A. (Greifswald, Germany) 

multimodal approaches for regenerative stroke therapies for aged rodents. 

(marS) 

4:15 – 4:30 PM Beretta S. (Monza, Italy) 

Hemodynamic monitoring of intracranial collateral flow predicts tissue and 

functional outcome in experimental ischemic stroke 


| 21



5:00 – 6:00 Pm nEUrorEgEnEraTion, PlaSTiCiTy anD rEHaBiliTaTion ii 

22 | 

Chairs: Carmichael T., Pluchino S. 

5:00 – 5:20 PM Düzel E. (Potsdam, Germany) INVITED 

Exercise-related brain plasticity in old age 

5:20 – 5:40 PM Nudo R. (Kansas, USA) INVITED 

advances in smart prosthetics for modulating neural pathways after brain injury 

5:40 – 6:00 PM Henrich-Noack P. (Magdeburg, Germany) 

Transcorneal alternating current stimulation increases long-term survival 

of neurons after severe axon damage 

6:00 – 6:30 Pm wHaT EmBryogEnESiS Can TEaCH US aBoUT rEgEnEraTion 

Chair: Boltze J. 

6:00 – 6:30 PM Snyder E. (La Jolla, USA) INVITED 

Cross-talk & developmental programs in stem cell biology – a key to translational 

neuroscience 

8:00 – 12:00 Pm SoCial EvEning aT THE BioSPHärE PoTSDam

Fire up your research with 

powerful data acquisition solutions 

Accelerate the pace of your research with ADInstruments 

industry-leading solutions. Our PowerLab ® systems are 

easy to use, intuitive and powerful, allowing you to start 

and progress research quickly. The fl exibility of the 

systems enables us to supply complete solutions for 

studies such as: 

• Brain plasticity 

• Traumatic brain injury 

• Functional connectivity 

• Wireless behavioural electrophysiology 

• Cerebral blood vessel structural & functional analysis 

What’s more, LabChart ® software (included with every 

system), displays up to 32 channels of data and features 

fast, automated analysis using add-on modules: Spike 

Histogram 2, Dose Response and Video Capture. You’ll 

also enjoy variable recording speeds, fl exible display 

options and unmatched data integrity. 

To fi nd out more, visit adinstruments.com/research 

ADInstruments Germany T: +49 6226 970 105 info.de@adinstruments.com 

ADInstruments UK neurorepair-2012.de 

T: +44 1865 332 050 info.uk@adinstruments.com


SaTUrDay, may 5, 2012 


8:30 – 10:00 am STEm CEll THEraPiES 

24 | 

Chairs: Steinberg G., Savitz S. I. 

8:30 – 9:00 AM Chopp M. (Detroit, USA) INVITED 

Stem cells, catalysts for recovery 

9:00 – 9:20 AM Mays R. (Cleveland, USA) 

kindly supported by Athersys Inc. 

Clinical Development of multiStem ® for Treatment of CnS injury and 

Disease 

9:20 – 9:40 AM Onteniente B. (Paris, France) INVITED 

Stem cell therapy with human iPSC in stroke 

9:40 – 10:00 AM Nikkhah G. (Freiburg, Germany) INVITED 

Stem cell-based repair in neurodegenerative diseases: Current challenges and 

perspectives 


10:30 – 11:30 am frEE CommUniCaTionS – STEm CEllS 

Chairs: Chopp M., Wagner D.-C. 

10:30 – 10:45 AM Pischiutta F. (Milano, Italy) 

long term survival and afficacy of human bone marrow mesenchymal stem cells 

in traumatized mice brain is not dependent on immunosuppressive treatment 

10:45 – 11:00 AM Rüger M.-A. (Cologne, Germany) 

Effects of minocycline on endogenous neural stem cells after experimental stroke 

11:00 – 11:15 AM Edenhofer F. (Bonn, Germany) 

Direct transdifferentiation of fibroblast cells into tripotent neural stem cells 

11:15 – 11:30 AM Falb R. I. (Ramat-Gan, Israel) 

Temporal analysis of CD20 expressed by adult neural progenitor cells



11:30 am – SUPPorTing lESionED anD aging BrainS – fUTUrE PErSPECTivES 

12:30 Pm 

Chair: Dirnagl U., Boltze J. 

11:30 AM – 12:00 PM Buchan A. (Oxford, UK) INVITED 

Dissecting the endogenous resistance of Ca3 neurons to global forebrain 

ischemia reveals hamartin as a novel neuroprotective target 

12:00 – 12:30 PM Dirnagl U. (Berlin, Germany) INVITED 

non-invasive imaging of cell death in the brain 

12:30 – 1:00 Pm CloSing SESSion 

awarding of aSn and Pluriselect poster prizes 

farewell comments 

| 25

PP I-2 

PoSTEr ExHiBiTion 

PoSTEr SESSion i, iii PoSTEr SESSion ii, iv 

PP I-26 

PP I – 2 – PP I – 19 

Cerebral ischemia i 

PP I – 20 – PP I – 41 

immunological and neurochemical aspects 

PP II – 1 – PP II – 19 

Cerebral ischemia ii 

PP II – 20 – PP II – 22 

miscellaneous 

PP II – 24 – PP II -34 

Stem Cells and neurogenesis 

26 | 

PP I-27 

PP III-14 

PP III-12 

PP I-13 PP I-14 

PP III-40 

PP III-1 

PP I-39 PP I-40 

PP III-28 PP III-29 

PP II-1 

PP II-17 

PP II-16 

PP IV-1 

PP II-34 

PP II-8 

PP III – 1 – PP III – 8 

imaging and novel Diagnostics 

PP III – 10 – PP III – 32 

neurodegenerative Diseases and the aged Brain 

PP III – 33 – PP III – 40 

Pharmacological Therapies 

PP IV – 1 – PP IV – 10 

neuroregeneration, astrogliosis and Plasticity 

PP IV – 11 – PP IV – 17 

new model Systems 

PP IV – 18 – PP IV – 36 

Cerebral ischemia iii 

PP II-9 

PP IV-19 

PP IV-18 

PP II-26 

PP II-25 

PP IV-36 

PP IV-10 

PP IV-8 

PP IV-27 

PP IV-26



PP i – 2 anti-Tnf therapy improves behavioural outcomes after pmCao in mice 

Couch Y., Anthony D., Clausen B.H., Ormhoej M., Martin N.A., Bergholdt Schmidt M.-L., Deierborg T., 

Petit G., Szymkowski D., Finsen B., Lambertsen K.L. 

PP i – 3 ablation of endogenous neural stem cells in experimental stroke worsens neurological 

outcome 

Bacigaluppi M., Amatruda M., Peruzzotti- Jametti L., Butti E., Comi G., Sessa M., Martino G. 

PP i – 4 Paradoxical effect of no-cgmP pathway on cerebral ischemia-induced impairment of kv 

current on vascular smooth muscle cells 

Bastide M., Plaisier F., Devedjian J.-C., Ouk T., Petrault M., Bordet R. 

PP i – 5 Cognitive deficit and hippocampic atrophy in a long term rat experimental stroke model 

Bastide M., Delattre C., Auger F., Devedjian J.-C., Ouk T., Bordet R. 

PP i – 6 Piroxicam renders neuroprotection in animal model of focal cerebral ischemia: a possible 

role of aquaporin-4 

Bhattacharya P., Pandey A., Paul S., Patnaik R. 

PP i – 7 Upregulation of cerebrovascular 5-ht1b receptors in secondhand smoke exposed rats 

Cao L., Xu C.-B., Zhang Y., Cao Y.-X., Edvinsson L. 

PP i – 9 Treatment with bone marrow-derived alternatively activated macrophages after transient 

ischemia: a USPio-enhanced longitudinal mri study in rats. 

Riou A., Chauveau F., Cho T.-H., Marinescu M., Nataf S., Moisan A., Remy C., Barbier E., 

Nighoghossian N., Wiart M., Berthezène Y. 

PP i – 10 Hypoxia/ischemia in p7 mouse brain produces trem2 overexpression and changes in 

micro glia/macrophages pattern 

Chertoff M., Shrivastava K., Llovera G., Recasens Torne M., Gimenez Llort L., Acarin L. 

PP i – 11 Distinct subsets of interleukin-1 receptor antagonist producing cells are neuroprotective 

after focal cerebral ischemia in mice 

Clausen B.H., Lambertsen K.L., Babcock A., von Linstow C.U., Deierborg T., Finsen B. 

PP i – 12 interferon-β modulates the inflammatory/immune response during the first week after 

experimental stroke 

Inacio A.R., Liu Y., Kucharz K., Stankovich T., Hjelm Clausen B., Khorooshi R.M.H., Lambertsen K.L., 

Issazadeh-Navikas S., Deierborg T. 

PP i – 13 glutamate receptors in cortical gfaP/egfP-positive glial cells after ischemic injury 

Dzamba D., Honsa P., Rusnakova V., Kubista M., Chvatal A., Anderova M. 

PP i – 14 administration of the human dose of rt-Pa at different times after cerebral ischemia in a 

thrombo-embolic mouse model 

El Amki M., Lerouet D., Coqueran B., Orset C., Vivien D., Plotkine M., Marchand-Leroux C., Margaill I. 

PP i – 15 age dependent transcriptional response to stroke 

Frahm C., Sieber M., Jaenisch N., Brehm M., Witte O.W. 

PP i – 16 longitudinal assessments of cerebrovascular lesion development and endogenous 

neurogenesis activation in spontaneously hypertensive stroke-prone rats (SHrSP) 

Gelosa P., Mura E., Cova L., Silani V., Stramba-Badiale M., Busca G., Michailidis G., Tremoli E., 

Zanchetti A., Mauro A., Sironi L. 

| 27

PoSTEr SESSion 

PP i – 17 Prevention of ogD-mediated differentiated astrocyte death does not promote long-term 

survival of co-cultured naive neurons 

Gouix E., Blondeau N., Buisson A., Had-Aissouni L. 

PP i – 19 neuroprotective pathways in cerebral ischaemia: could hamartin hold the key to a novel 

stroke treatment? 

Hadley G., Papadakis M., Zhao Z., Buchan A. 

PP i – 20 PParβ/δ protects against ceramide-induced neurotoxicity 

Aleshin S., Reiser G. 

PP i – 21 interplay between polyunsaturated fatty acids, tocopherol and mitochondria in motor 

neuron survival 

Ayala V., Cacabelos D., Jové M., Boada J., Granado A.B., Gonzalo H., Pamplona R., Ugidos A.V., 

Pena S., Portero-Otin M. 

PP i – 22 Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis 

Bendix I., Sifringer M., Börne C., von Haefen C., Endesfelder S., Kalb A., Holifanjaniaina S., Prager S., 

Schlager G.W., Keller M., Jacotot E., Felderhoff-Mueser U. 

PP i – 24 The neurotoxic effects of aluminium and contribute to a phytotherapy ba Curcumin – 

Experimental study in mice 

Djebli N. 

PP i – 25 Different functional impairments of mitochondria isolated from spinal cord, cortex, brain 

stem, and cerebellum of SoD-1g93a mice 

Gellerich F.N., Gizatullina Z., Gaynutdinov T., Debska-Vielhaber G., Schwalenstöcker B., Ludolph A.C., 

Kunz W.S., Vielhaber S. 

PP i – 26 focussing on ischaemia-induced mitochondrial damage: Do inert gases represent a 

potentially neuroprotective approach in early stroke stages? 

Härtig W., Hobohm C., Michalski D. 

PP i – 27 acute peripheral and cns immune responses in hypercholesterolemic mice after mild brain 

ischemia 

Herz J., Hagen S.I., Hermann D.M., Doeppner T.R. 

PP i – 29 Physostigmine and neostigmine reduce the increased expression of il-1beta in the 

hippocampus and cortex after surgery combined with lPS-treatment 

Kalb A., von Haefen C., Sifringer M., Tegethoff A., Paeschke N., Kostova M., Feldheiser A., Spies C. 

PP i – 30 Toxic effects of very long-chain fatty acids on cellular parameters in alDP-deficient astrocytes 

Kruska N., Reiser G. 

PP i – 31 Selenium activates mitochondrial biogenesis, preserves mitochondrial function and reduces 

infarct volume after focal cerebral ischemia 

Li P.A., Mehta S., kumari S., Mendelev N. 

PP i – 33 Calcium-independent phospholipase a2 protects mitochondria under oxidative stress in rat 

brain cells 

Nordmann C., Strokin M., Reiser G. 

PP i – 34 Plasma independent generation of the complement factor C5a in neurons results in cell 

death under stroke-like conditions. 

Pavlovski D., Thundyil J., Taylor S., Arumugam T., Woodruff T. 

28 |



PP i – 35 Poly(aDP-ribose)polymerase inhibition modulates Sirtuin1 subcellular localization after in 

vivo cerebral oxidative stress 

Gueguen C., Plotkine M., Marchand-Leroux C., Besson V.C. 

PP i – 36 Cyclophilin a plays a crucial role in mitochondrial damage and glutamate-induced cell death 

in ht22 neurons 

Reuther C., Doti N., Ruvo M., Plesnila N., Culmsee C. 

PP i – 37 oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain 

Sifringer M., von Haefen C., Endesfelder S., Kalb A., Bendix I., Felderhoff-Müser U., Bührer C., 

Spies C.D. 

PP i – 38 Curcumin helps in treatment of neurodegenerative disorders 

Singh A.P. 

PP i – 39 Ca2+ signaling is disturbed in astrocytes from mouse model of human infantile neuroaxonal 

distrophy (inaD) 

Strokin M., Seburn K.L., Cox G.A., Martens K.A., Reiser G. 

PP i – 40 impact of actin filament Stabilization on microglia Phenotypes 

Uhlemann R., Gertz K., Endres M., Kronenberg G. 

PP i – 41 mitochondrial dysfunction in skin fibroblasts of patients with sporadic and familiar 

amyotrophic lateral sclerosis 

Debska-Vielhaber G., Gizatullina Z., Minin I., Schöler S., Zuschratter W., Kunz W.S., Gellerich F.N., 

Vielhaber S. 

PP ii – 1 inflammatory changes in the cerebrovasculature of obese mice may mediate enhanced 

responses to experimental stroke 

Haley M., Bray N., Robson F., McColl B., Lawrence C. 

PP ii – 2 long-term neuro-inflammatory consequences of tissue plasminogen activator and 

simultaneously administered hyperbaric oxygen in a rat model of thromboembolic stroke 

Härtig W., Heindl M., Laignel F., Küppers-Tiedt L., Grosche J., Kacza J., Schneider D., Hobohm C., 

Michalski D. 

PP ii – 3 Endocannabinoids reduce cerebral damage after hypoxic-ischemic event 

Hilario E., Lara-Celador I., Castro L., Lacalle J., Arteaga O., Goñi-de-Cerio F., Alonso D., Martinez- 

Orgado J., Garcia-Fuentes M., Alvarez A. 

PP ii – 4 neurogenic potential of D6/gfP-positive cells in the roof of the lateral ventricle following 

focal cerebral ischemia 

Honsa P., Pivonkova H., Anderova M. 

PP ii – 5 Boldine prevents the damage caused by oxygen and glucose deprivation in rat organotypic 

hippocampal cultures 

Loureiro K.F., Frozza R.L., Grudzinski P.B., Hoppe J.B., Souza D., Salbego C., Horn A.P. 

PP ii – 6 Transplantation of human umbilical cord blood-derived neural stem cells into ischemic rat 

brain reveals the presence of donor and host origin neurotrophic factors 

Jablonska A., Drela K., Wojcik-Stanaszek L., Zalewska T., Lukomska B. 

PP ii – 7 microglia-neutrophil interactions: a new field of application for the phagocytosis marker 

pHrodoTm König R., Riek-Burchardt M., Schneeberg J., Neumann J., Reymann K., Gunzer M. 

| 29


PP ii – 8 lack of microglial tumor necrosis factor is detrimental after focal cerebral ischemia in mice 

Lambertsen K.L., Sivasaravanaparan M., Fogtmann T., Andersen M.G., Clausen B.H., Nedospasov S., 

Stolp H., Anthony D., Finsen B. 

PP ii – 9 Protective effect of endocannabinoids after cerebral hypoxic-ischemic injury in perinatal 

rat model 

Lara-Celador I., Castro L., Alvarez A., Goñi-de-Cerio F., Arteaga O., Lacalle J., Alonso D., Alvarez F.J., 

Alvarez-Granda L., Hilario E. 

PP ii – 10 Do poly(adp-ribose)polymerase inhibitors possess anti-aggregant effects ? 

Lechaftois M., Bachelot-Loza C., Margaill I., Marchand-Leroux C., Plotkine M., Lerouet D. 

PP ii – 11 ischemic postconditioning in a neonatal stroke model 

Leger P.-L., Bonnin P., Renolleau S., Baud O., Charriaut-Marlangue C. 

PP ii – 12 The alzheimer’s drug memantine: an adjunct treatment to thrombolysis for stroke. 

Lesept F., Montagne A., Jullienne A., Hébert M., Agin V., Orset C., Lebehot A., Ali C., Maubert E., 

Vivien D. 

PP ii – 13 nonselective calcium channel blocker bepridil decreases secondary pathology in happsl 

mice after cortical lesion 

Lipsanen A., Flunkert S., Kuptsova K., Hiltunen M., Windisch M., Hutter-Paier B., Jolkkonen J. 

PP ii – 14 regulation of enhanced cerebrovascular expression of pro-inflammatory mediators via 

mek/erk pathway following experimental subarachnoid hemorrhage in rat 

Maddahi A., povlsen G., Edvinsson L. 

PP ii – 15 implication of poly(adp-ribose)polymerase in the effects of the recombinant tissue 

plasminogen activator on the blood-brain barrier after cerebral ischemia in mice 

Teng F., Garraud M., Palmier B., Coqueran B., Plotkine M., Marchand-Leroux C., Margaill I., 

Beray-Berthat V. 

PP ii – 16 glatiramer acetate: impact on infarct volume, inflammatory response and neurogenesis 

after permanent and transient cerebral ischemia in mice. 

Marine P., Nicolas D., Feriel A., Claude D., Bernard I L., Marc P., Nathalie K. 

PP ii – 17 The role of mast cells in blood brain barrier permeability after focal cerebral ischaemia 

McKittrick C., Carswell H. 

PP ii – 18 intra-arterial infusion of human bone marrow derived mesenchymal cells results in 

transient entrapment in the brain after cerebral ischemia in rats 

Mitkari B., Kerkelä E., Nystedt J., korhonen M., Huhtala T., Jolkkonen J. 

PP ii – 19 Cell permeable mkk7 inhibitor peptide, gadd45ß-i, a novel strategy against cerebral ischemia. 

Morelli F., Antoniou X., Camassa A., Tomasi S., Roderi P., Sclip A., Grande V., Arnaboldi A., Vercelli A., 

Borsello T. 

PP ii – 20 nmDa-receptor mediated excitotoxicity is involved in the pathogenesis of experimental 

cerebral malaria 

Lackner P., Wechselberger K.-M., Taferner B., Beer R., Broessner G., Helbok R., Dietmann A., 

Fischer M., Singewald N., Schmutzhard E. 

PP ii – 21 Quality of life in children with west Syndrome in Santiago de Cuba Paediatric Hospital. 

Naranjo Pelayo G. 

30 |



PP ii – 22 CEaCam1 in the developing neonatal brain and its impact on encephalopathy of prematurity 

Prager S., Keller M., Singer B.B., Bendix I., Schlager G.W., Herrmann R., Ergün S., Felderhoff-Mueser U. 

PP ii – 24 lowered oxygen increases proliferation and pluripotent/neural stem marker expression in 

huc-msc culture 

Drela K., Szablowska-Gadomska I., Jurga M., Lukomska B., Forazz N., McGuckin C., Domanska-Janik K. 

PP ii – 25 impact of retinoic acid on neural differentiation of embryonic stem cells 

Fronz U., Boltze J., Wagner D.C., Deten A. 

PP ii – 26 Expression of CD20 by adult neural progenitor cells: relevance to its role in differentiation 

Zilkha-Falb R. I., Gurevich M., Achiron A. 

PP ii – 27 Systemic versus local delivery of marrow stromal cells in a rodent stroke model 

Kirch R., Shariat K., Döbrössy M., Nikkhah G. 

PP ii – 29 Cell yield and composition of rat bone marrow mononuclear cells significantly depend on 

the isolation procedure 

Pösel C., Möller K., Fröhlich W., Emmrich F., Boltze J., Wagner D.-C. 

PP ii – 30 a combined experimental stroke therapy using g-CSf and syngeneic bone marrow 

mononuclear cells 

Pösel C., Scheibe J., Bothe V., Quente E., Glocke I., Kranz A., Fröhlich W., Möller K., Emmrich F., 

Boltze J., Wagner D.-C. 

PP ii – 31 Beneficial effect of human neural stem cells in spinal cord injury repair 

Romanyuk N., Amemori T., Turnovcová K., Jendelová P., Forostyak O., Dayanithi G., Onteniente B., 

Price J., Syková E. 

PP ii – 32 Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: 

role of bcl-2 

Almeida A., Queiroga C., Sousa M., Alves P., Vieira H. 

PP ii – 33 The therapeutic potential of neuroepithelial cells after rat spinal cord injury 

Wills T., Batchelor P., Howells D. 

PP ii – 34 in vitro and in vivo evidence that mesenchymal stem cells drive protective m2 microglia 

phenotype 

Zanier E.R., Pischiutta F., Riganti L., Turola E., Fumagalli S., D‘Amico G., Lecca D., Biagi E., 

Abbracchio M.P., Verderio C., De Simoni M.G. 

PP iii – 1 Challenges towards imaging blood borne macrophage infiltration into ischemic tissue 

Farr T.D., Dätwyler A.L., Lindquist R., Schellenberger E., Mueller S., Dirnagl U., Harms C. 

PP iii – 3 Histopathological analysis of the mri fogging effect after mCao in rats 

Kranz A., Deten A., Härtig W., Boltze J., Wagner D.C. 

PP iii – 4 mr imaging in mice for de- and regeneration studies of the injured and aging 

visual projection 

Kretz A., Haenold R., Hermann K.-H., Reichenbach J., Krempler K., Holthoff K., Weih F., Witte O. 

PP iii – 6 Characterizing disease-related neuronal network dysfunction with thallium autometallography 

Rönicke R., Lison H., Schneeberg J., Schröder U., Goldschmidt J., Schröder U., Reymann K. 

| 31


PP iii – 7 object-based analysis of astroglial reaction to ischemic brain injury 

Scheibe J., Glocke I., Kranz A., Boltze J., Wagner D.C. 

PP iii – 8 imaging changes of cerebral potassium metabolism in focal cerebral ischemia in rodents 

using thallium-diethyldithiocarbamate 

Dirnagl U., Reymann K.G., Schröder U.H., Baldauf K., Scheich H., Wunder A., Goldschmidt J., 

Goldschmidt J., Stöber F. 

PP iii – 10 Pyroglutamated amyloid beta generation in the rat brain 

Canneva F., Melis T., Dobner J., Ducatenzeiler A., Schilling S., Cuello C., von Hoersten S. 

PP iii – 11 The choroid plexus in the 3xTg-aD mice: towards a neurorestorative gene therapy 

Castro-Fuentes R., Brito-Armas J., Giménez-LLort L., Chillón M., Carmona E., Castro-Hernández J.R., 

Castañeyra A., González-Marrero I. 

PP iii – 12 neuroprotective propensity of selaginella delicatula (a pteridophyte) in a rotenone model 

of drosophila 

Chandran G., Muralidhara M. 

PP iii – 13 The effects of short-term nicotine administration on behavioral and oxidative stress 

deficiencies induced by a rat model of Parkinson’s disease 

Ciobica A., Hritcu L., Lefter R., Cojocaru D. 

PP iii – 14 The association between body mass index, cholesterol levels and brachial/aortic 

augmentation index versus the cognitive status in patients with cardiovascular risk factors 

Ciobica A., Joacabine C., Padurariu M., Mitu F. 

PP iii – 15 PParγ activation by cannabinoid win 55,212-2 protects against aβ-induced 

neuroinflammation through both Cb receptor-dependent and independent pathways 

Fakhfouri G., Rahimian R., Ahmadiani A., Haeri A., Dehpour A.R. 

PP iii – 16 Different energization of neuronal and astrocyte mitochondria: Pathophysiological 

consequences for neurodegeneration 

Gellerich F.-N., Gizatullina Z., Gaynutdinov T., Debska-Vielhaber G., Schmidt W., König R., Riek- 

Burchardt M., Reymann K., Vielhaber S. 

PP III – 18 The expression of glutaminyl cyclases is mouse strain-specific 

Waniek A., Indrischek H., Höpcke T., Höfling C., Koch B., Cynis H., Schilling S., Demuth H.-U., 

Hartlage-Rübsamen M., Rossner S. 

PP iii – 19 neuroprotective aspects of perineuronal and perisynaptic extracellular matrix in 

alzheimer‘s Disease 

Jäger C., Brückner G., Seeger G., Arendt T., Morawski M. 

PP iii – 20 an integrated approach to the vascular dementia and the vascular depression: development 

of the animal model and the pathomechanism of the chronic vascular injury 

Kim H.Y., Lee S.R., Choi B.-R., Han J.-S. 

PP iii – 21 Chronic cerebrovascular injury in a rat model with aging and metabolic syndrome 

Kim H.Y., Choi B.-R., Lee S.R., Han J.-S. 

PP iii – 24 Effects of a high-fat diet on the cerebrovasculature and neuroinflammation in an 

experimental model of alzheimer‘s disease 

Martins I., Knight E., Allan S., Lawrence C. 

32 |



PP iii – 27 Tropisetron partially reverts amyloid-beta-induced neurotoxicity in rats; possible 

involvement of 5-ht3 receptors 

Rahimian R., Fakhfouri G., Mousavizadeh K., Ejtemaei-Mehr S., Dehpour A.R. 

PP iii – 28 The roles of Parkinson‘s disease genes Pink1, Parkin and DJ-1 in modulating stroke-induced 

cellular damage through mitochondrial quality control pathways 

Safarpour F., Amini M., Haque M.E., hage A., Shen J., Slack R., Park D. 

PP iii – 29 n-terminal Pyroglutamate (pglu) formation of aβ38 and aβ40 Enforces oligomer 

formation and Potency to Disrupt Hippocampal lTP 

Schilling S., Schlenzig D., Rönicke R., Cynis H., Saido T., Reymann K., Demuth H.-U. 

PP iii – 30 age analysis of canine brain 

Schmidt F., Stolzing A., Seeger J., Meij B.P., Willems N., Tryfonidou M.A., Rofina J.E. 

PP iii – 31 The p75 neurotrophin receptor localization in blood-CSf barrier: expression in choroid 

plexus epithelium 

Spuch C., Carro E., Ortolano S., San Millan B., Teijeira S., Navarro C. 

PP iii – 33 influence of mildronate, an aza-butyrobetaine analogue, on the expression of trained-rat 

hippocampal proteins 

Beitnere U., Mandrika I., Isajevs S., Isajeva D., Pupure J., Svarcbahs R., Rumaks J., Svirskis S., 

Jansone B., Muceniece R., Kluša V. 

PP iii – 34 Screening for novel axonogenic agents, a peptide approach 

Buyens T., Verreet T., Gaublomme D., Landuyt B., Schoofs L., luyten W., Moons L. 

PP iii – 35 mycophenolate mofetil: neuroprotection and effects on temporal dynamics in glial 

proliferation, apoptosis and scar formation 

Ebrahimi F., Koch M., Pieroh P., Bechmann I., Dehghani F. 

PP iii – 36 Effects of Cerebrolysin on Schwann cells in vitro – with regard to application points in 

peripheral nerve regeneration 

Lucas B., Fansa H., Keilhoff G. 

PP iii – 38 free radical scavenger edaravone administration protects against tissue plasminogen 

activator induced oxidative stress and blood brain barrier damage 

Lukic-Panin V., Deguchi K., Yamashita T., Shang J., Zhang X., Tian F., Liu N., Kawai H., Matsuura T., 

Abe K. 

PP iii – 39 Small molecule Bid inhibitors prevent Drp1-dependent mitochondrial fission and cell death 

in neurons 

Oppermann S., Grohm J., Schrader F., Krasel C., Bünemann M., Schlitzer M., Plesnila N., Culmsee C. 

PP iii – 40 role of frataxin in erythropoietin- and carbamoylated erythropoietin- mediated 

neuroprotective effects in the mouse retina after acute retinal ischemia/reperfusion in vivo 

Schultz R., Witte O., Schmeer C. 

PP iv – 1 tPa recycling by astrocytes is neuroprotective. 

Briens A., Cassé F., Parcq J., Vivien D., Docagne F. 

PP iv – 2 role of naDPH oxidase-1 in ischemic neurogenesis after stroke 

Choi D.-H., Lee K.-H., Kim J.-H., Kim H.Y., Lee J. 

| 33


PP iv – 3 Effect of Early Task-Specific Training on functional recovery and Corticospinal Tract 

Plasticity after Stroke 

Lee K.-H., Choi D.-H., Kim J.-H., Lee J. 

PP iv – 4 microtubule stabilization reduces scarring and causes axon regeneration after spinal cord 

injury 

Hellal F., Hurtado A., Ruschel J., Kevin F., Laskowski C., Umlauf M., Kapitein L., Strikis D., Lemmon V., 

Bixby J., Hoogenraad C., Bradke F. 

PP iv – 5 microglia derivation from human induced pluripotent stem cells as a therapy for 

alzheimer’s disease 

Naaldijk Y., Stolzing A. 

PP iv – 6 gene expression profile of the rat brain after repetitive transcranial magnetic stimulation 

Oh B.-M., Choi J.K., Lee S.A., Bang M.S., Park W.Y., Han T.R. 

PP iv – 8 altered extracellular matrix produced by glial cells after cortical laser lesions 

Roll L., Eysel U.T., Faissner A. 

PP iv – 10 Specific phosphorylation of αa-crystallin and αB-crystallin are required for protection of 

astrocytes against staurosporine and C2-ceramide toxicity 

Zhu Z., Li R., Reiser G. 

PP iv – 11 Human neurons derived from embryonic stem cells provided a useful model for drug 

screening 

Antonic A., Dottori M., Leung J., Sieg F., Donnan G., Howells D. 

PP iv – 12 neuroprotective effect of astrocyte conditioned medium 

Jaklin M., Boltze J., Peters M. 

PP iv – 13 rat brain pericytes in primary culture: establishing optimal growth conditions 

Redzic Z., Buchan A. 

PP iv – 15 an animal model of controlled cerebral air microembolism 

Schleicher N., Walberer M., Yeniguen M., Nedelmann M., Bachmann G., Urbanek P., Schoenburg M., 

Walther T., Gerriets T. 

PP iv – 16 modification of the intravascular filament occlusion technique to enable long-term studies 

in a rat permanent focal cerebral ischemia model 

Shanbhag N., Schilling L. 

PP iv – 17 The power of SUmo – a new approach to neuroprotection 

Wielsch B., Scheibe J., Wagner D.-C., Boltze J., Peters M. 

PP iv – 18 The role of stress hormones in post-ischemic immunosuppression 

Mracsko E., Liesz A., Karcher S., Veltkamp R. 

PP iv – 19 Effects of short duration hypothermia on intracranial pressure following ischaemic stroke 

Murtha L., McLeod D., Spratt N. 

PP iv – 20 genetic variation in Tlr2, Tlr4 and CD14 and outcome after ischemic stroke 

Olsson S., Jood K., Engström G., Blomstrand C., Norrving B., Melander O., Lindgren A., Jern C. 

PP iv – 21 glucagon-like peptide-1 receptor activation reduces ischemic brain damage following 

stroke in type 2 diabetic rats 

Olverling A., Darsalia V., Mansouri S., Sjöholm î, Patrone C. 

34 |



PP iv – 22 Hypoxic-ischemic brain injury: astrocyte response and enzymatic changes in the cerebral 

cortex of neonatal rats 

Pimentel V., Schetinger M., Da Luz S., Moretto M. 

PP iv – 23 Carbon monoxide prevents neuronal apoptosis by astrocytic metabolism modulation: 

purinergic signalling 

Queiroga C., Alves R., Conde S., Alves P., Vieira H. 

PP iv – 24 Evolution of ischemic damage over 6 months after thread occlusion mCao. 

Rewell S., Sidon K., Aleksoska E., Howells D. 

PP iv – 25 influences of the proinflammatory cytokine Tnfα on spreading depolarization (SD) in adult 

rat cortex 

Richter F., Lehmenkühler A., Lütz W., Hetke F., Schaible H.-G. 

PP iv – 26 Dissecting rhoa contribution to neurodegeneration and neurorepair in brain ischemia 

Santos S.D., Fonseca A.C., Abreu A.A.P., Ribeiro T.S., Lambertsen K.L., Relvas J. 

PP iv – 27 a novel model for neurogenesis studies 

Schröder U.H., Garz C., Zavala R., Reymann K.G. 

PP iv – 28 neuroprotection by bilobalide: what is the mode of action? 

Schwarzkopf T.M., Klein J. 

PP iv – 31 Examination of sensorimotor and cognitive function in rats following 90-and120-min 

transient occlusion of the middle cerebral artery 

Svalbe B., Zvejniece L., Pulks E., Dambrova M. 

PP iv – 32 Suppression of glutamate release underlies in vitro ischemic tolerance induced by synaptic 

activity-preconditioning 

Tauskela J., Aylsworth A., Hewitt M., Brunette E., Mealing G. 

PP iv – 33 role of epha2 receptor tyrosine kinase in ischemic stroke outcome 

Thundyil J., Manzanero S., Pavlovski D., Coulthard M., Arumugam T. 

PP iv – 34 Thromboembolic stroke with site-specific delivery of platelet rich clots 

Tomkins A.J., Murtha L., McCann S., Pepperall D., Levi C.R., Spratt N.J. 

PP iv – 35 gelatinases (mmP-2,mmP-9) as factors regulating neurogenesis- associated processes 

Wojcik-Stanszek L., Szymczak P., Nalecz M., Sypecka J., Zalewska T. 

PP iv – 36 Specific imaging of cell death in experimental stroke using fluorescent and radioactively 

labeled annexin a5 

Zille M., Schellenberger E., Bahmani P., Kratz H., Dirnagl U., Wunder A. 

| 35

SCHolarSHiP 

THE winnEr of THE iBro SCHolarSHiP 

Bhattacharya, Pallab (india) 

Piroxicam renders neuroprotection in animal model of focal cerebral ischemia: A possible role of Aquaporin-4 

Chandran, girish (india) 

Neuroprotective propensity of selaginella delicatula (a pteridophyte) in a rotenone model of drosophila 

fakhfouri, gohar (iran) 

PPARγ activation by cannabinoid win 55,212-2 protects against Aβ-induced neuroinflammation through both Cb 

receptor-dependent and independent pathways 

lukic-Panin, violeta (Serbia) 

Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative 

stress and blood brain barrier damage 

THE winnEr of THE iSn SCHolarSHiP 

Bacigaluppi, marco (italy) 

Ablation of endogenous neural stem cells in experimental stroke worsens neurological outcome 

Honsa, Pavel (Czech republic) 

Neurogenic potential of d6/gfp-positive cells in the roof of the lateral ventricle following focal cerebral ischemia 

naaldijk, yahaira (germany) 

Microglia derivation from human induced pluripotent stem cells as a therapy for Alzheimer’s disease 

Pischiutta, francesca (italy) 

Long term survival and afficacy of human bone marrow mesenchymal stem cells in traumatized mice brain is 

not dependent on immunosuppressive treatment 

rewell, Sarah (australia) 

Evolution of ischemic damage over 6 months after thread occlusion MCAo. 

Thundyil, John (australia) 

Role of epha2 receptor tyrosine kinase in ischemic stroke outcome 

36 |

noTES 



| 37

ExHiBiTion / SPonSorS 

no. Company 

7 Abcam plc 

ADInstruments Ltd. 

13 AJ Roboscreen GmbH 

12 analysio GmbH 

ASN NEURO 

Athersys, Inc. 

BioMedical Instruments – Dr. Joachim Gündel 

8 Bitplane 

14 Blackrock Microsystems 

Carl Zeiss MicroImaging GmbH 

20 Cenibra GmbH 

19 Charles River Research Models and Services, 

Deutschland GmbH 

16 Cytolon AG 

12 DMT Demminer Maschinenbau Technik GmbH 

Dr. Ing. h.c. F. Porsche AG 

12 Dr. Popa – Bedarf Medizinischer Forschung 

Fine Science Tools GmbH 

15 HiSS Diagnostics GmbH 

3 Hugo Sachs Elektronik – Harvard Apparatus GmbH 

InTech – open science | open minds 

38 | 

Main Entrance 

Reception Registration 

1 2 

3 

Poster 

Exhibition 

I, III 

8 

7 

6 

Poster 

Exhibition 

II, IV 

4 

9 

5 

Buffet 

Buffet 

20 19 

Poster Exhibition 

10 11 12 

18 

14 

13 

15 16 17 

Entrance 

Lecture Hall 

Speakers 

Preview 0-214 

no. Company 

International Graduate Program Medical Neurosciences 

und MSc in Cerebrovascular Medicine 

an der Charité – Universitätsmedizin Berlin 

2 Keyence Deutschland GmbH 

KF Technology srl 

9 Life Technologies GmbH 

18 Merck Millipore 

MicroBrightField Europe e.K. 

MoBiTec GmbH 

1 Moor Instruments Ltd. 

Novartis Pharma GmbH 

Nuvo Research GmbH 

Open Biology 

6 PeproTech GmbH 

5 pluriSelect GmbH 

Pluristem Therapeutics Inc. 

4 Rogue Research Inc. 

Sarstedt AG & Co. 

10 Stoelting Europe 

11 TSE Systems GmbH 

17 VisualSonics 

Zinsser Analytic GmbH

main Sponsors 

HSE 

Hugo Sachs Elektronik 

HARVARD APPARATUS 



innovation in microvascular assessment 

Europe 

| 39

EvEning fUnCTionS 

40 | 

gET TogETHEr in THE ExHiBiTion arEa 

kongrESSHoTEl am TEmPlinEr SEE 


In addition to an exciting scientific program we are 

cordially welcome you to the official opening of the 

7th International Symposium on Neuroprotection and 

Neurorepair in Potsdam. 

It offers the opportunity to meet old colleagues and 

exhibitors coming from all over the world. Join us 

and enjoy the special atmosphere at the venue. 

included in the registration fee 

BarBECUE aT THE garDEn of THE 

kongrESSHoTEl am TEmPlinEr SEE 


Regenerate, Re-Energize and Relax at our Barbecue. 

Don’t miss this chance to mingle and mix with 

cutting edge researchers from every corner of the 

globe. Be our guest in the garden of the Kongresshotel 

at 8:00 pm. 

included in the registration fee




PlannED ToPiCS 

2014 


may 2014 | magdeburg, germany 

Neuroregeneration, plasticity and rehabilitation 

Imaging and novel diagnostics 

Neurodegeneration in stroke, Alzheimer dementia, 

and aging 

Vascular aspects of neurodegeneration 

Balancing immune responses in neurodegeneration 

Mitochondria as cellular targets for neuroprotection 

Supporting lesioned and aging brains – future perspectives 

Hot news on successful therapeutic translations 

neurorepair-2014.de 

| 41

EvEning fUnCTionS 

42 | 

SoCial EvEning aT THE BioSPHärE PoTSDam 


The Tropical camp is situated on the second level of the Biosphäre 

and lies right by a tropical lake. It has been designed in a tropical 

style and emanates a relaxing atmosphere. Our guests can 

experience a tropical storm on an hourly basis, including thunder, 

lightning and rainfall. 

Be our guest in this unique scenery and don’t miss the chance to 

mingle with colleagues and friends in the evening of May 4, 2012. 

Limited tickets can be purchased at the price of 65,00 EUR. 

Bus transfer: 07:30 pm from the Kongresshotel



The moment technology provides 

you with a result the first time. 

This is the moment we work for. 

Carl Zeiss MicroImaging is a provider of advanced microscopy systems for biomedical and 

materials applications. We provide the latest technology for measuring, analysis and 

processing in the fields of research and industry. 

www.zeiss.de/micro 

// CONFIDENCE 

MADE BY CARL ZEISS 

| 43


44 | 

Cardiovascular 

Diseases 

Cell Therapies 

Musculoskeletal 

Injuries 

Autoimmune 

Diseases 

CNS 

Disoders 

Headquarters 

Daya Lettvin 

Investor & Media Relations Director 

Tel: +972 (54) 674-5580 

daya@pluristem.com 

Radiation 

Sickness 

Readily Available 

From the Miracle of Birth 

to Therapeutics for All 

Pluristem Therapeutics Inc. (NasdaqCM: 

PSTI; TASE: PLTR) is a leading developer 

and manufacturer of standardized cell 

therapy products for the treatment of life 

threatening diseases. The company's 

patented PLX (PLacental eXpanded) cell 

drug delivery platform releases a variety 

of therapeutic proteins in response to 

numerous local and systemic ischemic 

and inflammatory diseases. 

U.S.A. 

William R. Prather, RPh, MD 

Sr. VP Corporate Development 

Tel: +1 (303) 883-4954 

William.PratherMD@pluristem.com 

Pluristem Therapeutics Inc., MATAM Park, Bldg. #20, Haifa 31905, Israel 

www.pluristem.com 

The information contained in this document does not constitute an offering. Potential purchasers of the Company's 

stock should carefully review the risk factors. The information provided herein is only partial information. For full 

information please review the Company's filings with the SEC, which can be found at www.sec.gov. 

Pulmonary 

Hypertension 

www.mootagoc.com

final Program - Neurorepair 2012

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?