Wellness Foods + Supplements 1/2022

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages.

Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.


You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

No. 1, April/May <strong>2022</strong><br />

www.harnisch.com | ISSN 2364-8104<br />

Functional ingredients Gut health<br />

Dietary fibres Micronutrients<br />

Marine ingredients Skin health<br />

Sports nutrition Oils and fats

Let Your Inspiration Flow<br />

World’s Leading Trade Fair for the<br />

Beverage and Liquid Food Industry<br />

September 12–16, <strong>2022</strong><br />


Editorial<br />

SILKE WATKINS, Editor-in-Chief<br />

Overall well-being – a noble goal<br />

Vitafoods Europe is opening its doors in<br />

May as usual again this year. A look at the<br />

trade fair’s main focus areas shows that this<br />

edition is in tune with the times.<br />

Mental health is a topic that is gaining<br />

consider ably more attention going forward.<br />

Countless people have been under enormous<br />

stress and strain over the last two<br />

years. For many, this was compounded by<br />

sleep disturbances. Families in particular<br />

and especially children suffered. The mental<br />

stress of children and adolescents in the<br />

course of the pandemic remains high. A<br />

study conducted by the Hamburg-Eppendorf<br />

University Hospital did however find<br />

a small but significant improvement in the<br />

mental health of children.<br />

With regard to mental health, the microbiome<br />

is also deserving of special attention.<br />

This microbial community influences<br />

the way food is digested, the activity level<br />

and fitness of the immune system, and the<br />

functioning of the central nervous system.<br />

A number of illnesses are being linked to a<br />

disturbed microbiome today.<br />

Functional substances not only contribute to sound digestion and<br />

intestinal health as well as strengthening the body’s defences, they<br />

also increase the availability of minerals such as calcium, magnesium,<br />

iron and zinc.<br />

The importance of omega-3 fatty acids has long since been proven,<br />

along with their tremendous significance in sports. They have a positive<br />

effect on brain development in children, and can boost cognitive<br />

flexibility and therefore also counteract dementia. Supplementing<br />

with omega-3 fatty acids can considerably improve the anti-oxidative<br />

capacity in case of macular degeneration due to age. This also<br />

applies to taking micronutrients.<br />

Combining all of these topics already gets us very close to overall<br />

well-being. Surprisingly, many of these things are related and influence<br />

each other.<br />

I wish you an interesting read!<br />

Warmest regards,<br />

Silke Watkins<br />

The microbiome makes an important contribution<br />

to human health. Studies point to a<br />

connection between a healthy microbiome<br />

and healthy skin, but also healthy ageing<br />

and a longer life.<br />

No. 1 April/May <strong>2022</strong><br />


Contents<br />

Health<br />

Convenience Food<br />

Food & Beverages<br />

Confectionary<br />

Cover Photo © : Indena S.p.A.<br />

More than 150 million people annually (1), are affected<br />

by urinary tract infections (UTIs) which are among the<br />

most frequent infections in clinical practice worldwide.<br />

UTIs can affect any part of the urinary system although<br />

the organs where they most frequently develop are the<br />

bladder and urethra. Cranberry products have beneficial<br />

role for urinary tract wellbeing because they can<br />

control R-UTIs episodes frequencies, as observed by<br />

several studies. The complex mixture of proanthocyanidins<br />

(PACs), flavonols and phenolicacids contained in<br />

cranberry extract seems to level biofilm formation and<br />

tissues pricking.(see Cover story at page 6)<br />

Sports Nutrition<br />

Health Care<br />

Personal Care<br />

Contents<br />

Cover story<br />

06 Urinary health maintenance, a goal for millions of people<br />

Functional ingredients in gut health<br />

08 Naticol ® Gut: a key ingredient in gut health<br />

Dietary fibres and overall wellbeing<br />

12 More than gut health: Fibre contributes to overall wellbeing<br />

Microbiome<br />

15 Gut health 2.0 – The increasing role of the microbiome<br />

Bioactives for stress and sleep wellbeing<br />

19 Lactium ® , a natural bioactive for mental wellbeing praised by its consumers!<br />

Marine ingredients in sports nutrition<br />

20 A small revolution is underway in the world of lipids and marine ingredients<br />

Ceramides for skin health<br />

23 Ceramides: science supported lipids for skin health<br />

AMD and micronutrients<br />

26 Age-related macular degeneration: Micronutrients for prevention and therapy<br />

Minerals in sports nutrition<br />

32 Minerals in sports nutrition<br />

Active ingredients<br />

37 A “new generation” of liposomes<br />

Antioxidants in baked goods<br />

40 Natural solutions in baked goods. From early civilizations to modern innovation!<br />

Oils and fats<br />

43 Virgin coconut oil and MCT oil: effective energy suppliers<br />

Vitafoods Europe<br />

46 Vitafoods Europe returns in May <strong>2022</strong><br />

48 Vitafoods Europe – Preview<br />

50 Impressum<br />

4 No. 1 April/May <strong>2022</strong>

VIVA<br />


The world‘s nutraceutical event<br />

10–12 May <strong>2022</strong> Geneva<br />

Experience the latest trends and technologies<br />

in food supplements at the Vitafoods Europe<br />

trade fair, and visit us at VIVATIS booth I60!<br />

➜ Discover new delivery technologies and innovative product formats<br />

➜ Find out about our branded ingredients and their best formulations<br />

➜ Learn more about the newest member in the VIVATIS family: Probionova –<br />

our partner for innovative probiotic solutions<br />

WWW.VIVATIS.DE | NE@VIVATIS.DE | +49 (0)40 236 90 90

Cover story<br />

Photo © : Adobestock/eAlisa<br />

Urinary health maintenance, a goal<br />

for millions of people<br />

With Indena’s Anthocran ® Phytosome ® let’s shed new light on urinary tract health,<br />

enhancing cranberry potential<br />

More than 150 million people annually (1), are affected by urinary<br />

tract infections (UTIs) which are among the most frequent infections<br />

in clinical practice worldwide. UTIs can affect any part of the urinary<br />

system although the organs where they most frequently develop are<br />

the bladder and urethra.<br />

Such infections create clinical and economic burdens on healthcare<br />

systems, and negatively influence individuals’ quality of life as well.<br />

Recurrent lower urinary tract infections (R-UTIs) are common after<br />

urinary catheterization in surgical patients, but they may occur also<br />

in non-surgical patients, particularly in women, and are also common<br />

in men.<br />

Cranberry products have beneficial role for urinary tract wellbeing<br />

because they can control R-UTIs episodes frequencies, as observed<br />

by several studies. The complex mixture of proanthocyanidins<br />

(PACs), flavonols and phenolicacids contained in cranberry extract<br />

seems to level biofilm formation and tissues pricking.<br />

On the other hand, cranberry extract presents<br />

a problem of poor availability and bioabsorption,<br />

like many other natural compounds.<br />

That’s why Indena has developed a new<br />

health-food ingredient based on Phytosome ®<br />

formulation proprietary technology, able to<br />

enhance and optimize the delivery of Indena’s<br />

cranberry extract (Anthocran ® Phytosome ® )<br />

where the effects are needed.<br />

In addition to its better ability to reach tissues,<br />

thanks to the phytosome ® 100 % food grade<br />

formulation, cranberry extract (Anthocran ®<br />

Phytosome ® ) boasts a unique phytochemi cal<br />

characterization, which makes it the highest<br />

quality cranberry extract on the market;<br />

infact, it is standardized in proanthocyanidins<br />

(PACs: 6.0-9.0 % UV-visible spec-<br />

6 No. 1 April/May <strong>2022</strong>

Cover story<br />

trophotometric contents – DMAC method)<br />

and contains the full polyphenols profile of<br />

natural cranberry, including flavonols, anthocyanins<br />

and phenolic acids.<br />

A recent human urines pharmacokinetics<br />

study (2) has been done with the aim to<br />

profile, by using an HPLC-MS/MS method,<br />

cranberry compounds and metabolites<br />

found in human urine after supplementation<br />

of a highly standardized cranberry extract:<br />

Anthocran ® Phytosome ® . Two different strategies<br />

were adopted for the data analysis: a<br />

targeted and an untargeted approach. These<br />

strategies allowed the identification of 42<br />

analytes including cranberry components,<br />

known metabolites and metabolites hitherto<br />

unreported in the literature, including eight<br />

valerolactones/valeric acid derivatives whose<br />

presence in urine after cranberry consumption<br />

has never been described before.<br />

Moreover, the ex vivo study showed that urine<br />

fractions rich in these metabolites are the<br />

most active against the pathogen Candida<br />

so frequent in hospitalized patients; it can<br />

reach the 10 % of positive urine cultures in<br />

hospitals, intensive care units and tertiary<br />

care facilities.<br />

To support from a clinical point of view<br />

these interesting data, a pilot registry study<br />

(3) recently investigated the effects of the<br />

oral supplementation of a standardized<br />

Anthocran ® Phytosome ® for the support of<br />

urinary tract health.<br />

reported to have a more favorable actions in managing UTI discomforts<br />

(like urinary frequency, urinary urgency, dysuria and nocturia),<br />

as assessed on the visual analogue scale, compared with subjects in<br />

the standard management or nitrofurantoin groups.<br />

No subjects with blood in urines and with traces of bacterial infection<br />

in urine in the group treated with the supplement compared with<br />

controls (p < 0.05). The cranberry extract was also superior to the<br />

control management in terms of recurrence of signs, with none of the<br />

subjects in this group reporting a R-UTI in the 3-months following the<br />

study end (p < 0.05).<br />

The supplementation showed an optimal safety profile, with no significant<br />

adverse events and no drop-outs in the supplement group.<br />

The study shows that cranberry extract (Anthocran ® formulated as<br />

Phytosome ® ) is a valid diet supplementation for subjects where postoperative,<br />

post-catheter R UTIs may occur, whit a good tolerability<br />

profile.<br />

References<br />

1 World J Urol. 2020 Nov;38(11):2669-2679. doi: 10.1007/s00345-019-03071-4.<br />

Epub 2020 Jan 10.)<br />

2 Giovanna Baron et alii, Biochemical Pharmacology 173 (2020) 113726<br />

3 Roberto Cotellese, Andrea Ledda, Gianni Belcaro, Maria R. Cesarone, Claudia Scipione,<br />

Valeria Scipione, Mark Dugall, Beatrice Feragalli, Antonella Riva, Pietro Allegrini,<br />

Giovanna Petrangolini & Stefano Togni (2021):, DOI: 10.1080/19390211.2021.1972074<br />

For more information, please contact<br />

Laura Bo<br />

External Communication and<br />

Sustainability, Indena S.p.A.<br />

laura.bo@indena.com<br />

www.indena.com<br />

The study included 64 otherwise healthy<br />

subjects who underwent a surgical procedure<br />

and required post-surgical urinary<br />

catheterization. The subjects have been<br />

divided by randomization in four groups:<br />

12 subjects were given supplementation<br />

with the standardized cranberry extract at<br />

the dose of either 120 mg/day, 12 subjects<br />

at 240 mg/day, 18 subjects were assigned<br />

to a control group consisting of standard<br />

management and 22 to a group with nitrofurantoin<br />

administration for four weeks to<br />

relief the R UTIs.<br />

At the end, subjects receiving the standardized<br />

cranberry Phytosome ® supplementation<br />

No. 1 April/May <strong>2022</strong><br />


Functional ingredients in gut health<br />

Naticol ® Gut: a key ingredient in gut health<br />

Weishardt patented fish collagen peptides modulate intestinal inflammation<br />

Mouna Rahabi, PhD<br />

Inflammatory bowel diseases (IBD) are chronic inflammatory<br />

diseases affecting the gastrointestinal tract. Remaining<br />

largely unclear, the etiology of IBD involves a complex interaction<br />

between genetics, environmental and microbial<br />

factors and immune responses 1 .<br />

In fact, there is clear evidence that the prevalence of IBD is associated<br />

with the environment as demonstrated by a north-south gradient<br />

of the disease prevalence which is markedly higher in industrialized<br />

countries. The rapid incidence increase of IBD over the last decades<br />

is believed to be associated with the introduction of the “western diet”<br />

across the world. Indeed, diet can influence intestinal inflammation<br />

by different pathways essentially by altering gut microbiota, affecting<br />

gut permeability or triggering immune responses 2 . Thus, it appears<br />

that nutrients intake can modulate gut inflammatory status. Although<br />

many approaches focus on the use of probiotics in intestinal inflammation,<br />

only few studies target nutrients such as collagen peptides<br />

in this context 3 .<br />

Besides, an important number of studies<br />

have been conducted to demonstrate<br />

the anti-inflammatory activity of collagen<br />

peptides in osteoarthritis but, until now, there<br />

was no clear evidence on their impact on<br />

intestinal inflammation.<br />

Naticol ® Gut<br />

Weishardt scientific team has worked on<br />

transposing fish collagen peptides bioactivity<br />

to gut inflammation and provide today solid<br />

evidence that the new patented Naticol ®<br />

Gut fish collagen peptides have a beneficial<br />

effect in this axis. Indeed, Naticol ® Gut<br />

reduces experimental colitis severity in an<br />

immune system-dependent manner that<br />

consequently leads to a healthier gut micro-<br />

8 No. 1 April/May <strong>2022</strong>

Functional ingredients in gut health<br />

biota. These complete pre-clinical results are corroborated by the<br />

very encouraging fact that Naticol ® Gut also restores the anti-inflammatory<br />

phenotype of immune cells from subjects suffering from IBD.<br />

Naticol ® Gut displays an anti-inflammatory<br />

and anti-oxidant activity in gut<br />

Gut immune system is largely involved in the inflammatory status of<br />

gastric tract. Among immune cells, macrophages represent a population<br />

that plays a key role in gut balance. In physiological conditions,<br />

gut macrophages do not react to the gut microbiota thereby<br />

avoiding inappropriate immune reactions. Conversely, in IBD there<br />

is a massive infiltration of macrophages leading to the rupture of the<br />

intestinal barrier by displaying pro-inflammatory and pro-oxidant<br />

activities 4 . The experimental model of colitis in which Naticol ® Gut<br />

activity was assessed, is based on a chemical induction (Dextran<br />

Sodium Sulfate, DSS) of intestinal inflammation with symptoms<br />

and biological changes that can be assimilated to human ulcerative<br />

colitis 5 . Interestingly, Naticol ® Gut-treated DSS mice displayed a lower<br />

degree of colonic inflammation as reflected by less immune cells infiltrate,<br />

crypts loss, and epithelial erosion on histological sections of the<br />

colon (Fig. 1).<br />

Photo © : istockphoto/shironosov<br />

Fig. 1: Histological staining of representative cross-sections of colon<br />

Furthermore, it is demonstrated that Naticol ® Gut is able to switch the<br />

phenotype of colonic inflammatory macrophages generated by DSS<br />

administration towards an anti-inflammatory and anti-oxidant pheno-<br />

Lipoid GmbH | info@lipoid.com | www.lipoid.com<br />

NEW<br />

PhytoSolve ® Products – Liposomes<br />

and Emulsions for Immune Health<br />

• Optimized absorption of lutein, omega-3<br />

fatty acids, vitamin C or D3<br />

• Transparent formulations with natural<br />

phospholipids, mixable with water<br />

We Invest in Quality.

Functional ingredients in gut health<br />

Gut microbiota represents one of the most incriminated components<br />

in IBD development. Indeed, in intestinal inflammation, there<br />

is a disruption of the harmonious relationship between the microbiota<br />

and the immune system. Microbiota becomes unbalanced<br />

and immune system overactivated. The unbalanced microbiota,<br />

called dys biosis, is characterized by an increase of the “aggressive”<br />

species and a impoverishment in the probiotic species 7 . Interestingly,<br />

Naticol ® Gut administration consistently decreases the burden<br />

of “bad” bacteria and yeast such as Escherichia coli or Candida<br />

albicans while it enriches populations of protective bacteria and<br />

yeast such as Saccharomyces cerevisiae or Lactobacillus sp. Our<br />

study demons trates that this modulation of gut microbiota is exerted<br />

through the effect of Naticol ® Gut on the immune system via a crosstalk<br />

between both components 6 (Fig. 3).<br />

Fig. 2: Cytokine expression by macrophages<br />

##p ≤ 0.01, ###p ≤ 0.005, ####p ≤ 0.001 DSS-exposed mice compared<br />

to DSS-exposed mice treated with Naticol ® Gut<br />

type (Fig. 2). This effect on macrophages reverberates on the whole<br />

immune system as the global pro-inflammatory mediators’ production<br />

is significantly dampened by Naticol ® Gut 6 .<br />

Naticol ® Gut impacts gut microbiota<br />

Fig. 3: microbiota fluctuation<br />

#p ≤ 0.05, ##p ≤ 0.01, DSS-exposed mice compared to DSS-exposed mice<br />

treated with Naticol ® Gut<br />

Conclusion<br />

The use of functional ingredients in gut health management is an<br />

emerging concept. In this context, Weishardt provides solid preclini<br />

cal results as well as an encouraging translational approach using<br />

immune cells directly collected from human subjects and in which<br />

results show that Naticol ® Gut restores an anti-inflammatory profile.<br />

Last but not least, Weishardt has taken the science behind fish<br />

collagen peptides to a deeper level of understanding by highlighting<br />

the mechanism by which Naticol ® Gut exerts its beneficial effects.<br />

References<br />

1<br />

Actis, G. C., Pellicano, R., Fagoonee, S. & Ribaldone, D. G. History of Inflammatory Bowel<br />

Diseases. J. Clin. Med. 8, 1970 (2019).<br />

2<br />

Rajendran, N. & Kumar, D. Role of diet in the management of inflammatory bowel disease.<br />

World J. Gastroenterol. WJG 16, 1442–1448 (2010).<br />

3<br />

Rossi, R. E. et al. The role of dietary supplements in inflammatory bowel disease: a<br />

systematic review. Eur. J. Gastroenterol. Hepatol. 28, 1357–1364 (2016).<br />

4<br />

Kühl, A. A., Erben, U., Kredel, L. I. & Siegmund, B. Diversity of Intestinal Macrophages in<br />

Inflammatory Bowel Diseases. Front. Immunol. 6, (2015).<br />

5<br />

Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium<br />

(DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, 15.25.1-15.25.14 (2014).<br />

6<br />

Rahabi, M. et al. Bioactive fish collagen peptides weaken intestinal inflammation by<br />

orienting colonic macrophages phenotype through mannose receptor activation. Eur. J.<br />

Nutr. (<strong>2022</strong>) doi:10.1007/s00394-021-02787-7.<br />

7<br />

Ni, J., Wu, G. D., Albenberg, L. & Tomov, V. T. Gut microbiota and IBD: causation or correlation?<br />

Nat. Rev. Gastroenterol. Hepatol. 14, 573–584 (2017).<br />

Photo © : Shutterstock/rangizz<br />

For more information, please contact<br />

WEISHARDT International<br />

81300 Graulhet, France<br />

Phone +33 5 63 42 14 41<br />

welcome@weishardt.com<br />

www.weishardt.com<br />

10 No. 1 April/May <strong>2022</strong>

Connect with<br />

nutraceutical<br />

experts<br />

This year, Vitafoods Europe <strong>2022</strong> returns to its annual<br />

May slot in your diary. As it’s a hybrid event you’ll be<br />

able to join us in person and online to share ideas,<br />

see new products, source ingredients and innovate<br />

with an inspiring community of experts. This is your<br />

chance to connect with industry-leading buyers,<br />

suppliers and manufacturers from over 110 countries,<br />

so don’t miss it.<br />

Register for your free<br />

badge now and save €160*<br />

Geneva: 10-12 May<br />

Online: 2-13 May<br />

For more details visit<br />

vitafoods.eu.com<br />

*Onsite visitor registration will cost €160

Dietary fibres and overall wellbeing<br />

Photo © : Shutterstock/Monkey_Busines<br />

More than gut health: Fibre contributes<br />

to overall wellbeing<br />

Natural fibre Sunfiber ® counteracts dietary deficiencies – even in those with digestive problems<br />

Dr Stefan Siebrecht<br />

For a long time, dietary fibre was thought of as useless and<br />

even burdensome because of its indigestible properties – until<br />

the first indications of its positive effects on the body emerged.<br />

Nowadays, those previously held opinions have been overturned,<br />

and experts recommend integrating “dietary fibre” into<br />

the diet in much larger quantities for a variety of reasons, from<br />

digestive health to emotional wellbeing.<br />

The World Health Organisation (WHO) recommends a daily intake<br />

of 30 g of dietary fibre. In most European countries, however, the<br />

average consumption is far below this amount. If you look at the fibre<br />

content of popular foods – avocados, for example, contain about 7 g<br />

of fibre per 100 g, and apples about 2 g per 100 g – it becomes clear<br />

that the modern eating habits and taste preferences of Western diets<br />

are not sufficiently balanced when it comes to fibre intake. Important<br />

sources such as whole grains, legumes, fruits and vegetables<br />

are not consumed in sufficient amounts to<br />

meet daily requirements. 1 Therefore, fortifying<br />

or supplementing foods and beverages<br />

with dietary fibre offers a promising approach<br />

to improving overall intake and, thus, the<br />

general health of the population.<br />

Prebiotic ingredients like Taiyo’s partially<br />

hydrolysed guar gum (Sunfiber ® ) make it easy<br />

to add fibre to all sorts of foods and beverages,<br />

and fortified products are a pleasant way for<br />

consumers to boost their health and wellbeing.<br />

Sunfiber ® is easy to process, its positive effect<br />

on the digestive tract is scientifically proven,<br />

and foods containing it can be labelled with<br />

the EU Nutritional Claim “high in fibre”.<br />

12 No. 1 April/May <strong>2022</strong>

Dietary fibres and overall wellbeing<br />

The importance of dietary fibre<br />

Scientific research has repeatedly shown<br />

that our overall health depends to a large<br />

extent on the health of the gut, which is home<br />

to about 100 trillion bacteria from 1,000<br />

different species. This “microbiome” has<br />

many functions, including supporting digestion,<br />

nutrient absorption and the immune<br />

system. Studies in recent years have also<br />

confirmed that the gut is in direct contact<br />

with the emotional centre of the brain. By<br />

changing the gut microbiome, it has been<br />

proven that neurobiochemistry, behaviour<br />

and even personality can be significantly<br />

altered. 2<br />

The microbiome is directly affected by what<br />

we eat: a high-sugar, low-fibre diet feeds<br />

harmful bacteria, while a diet high in fibre<br />

and low in sugar has the opposite effect: It<br />

supports beneficial gut bacteria diversity to<br />

help regulate blood sugar, fight inflammation<br />

and produce the substances required for a<br />

healthy brain.<br />

After consuming dietary fibre, blood glucose<br />

levels rise only moderately and remain<br />

constant for a lengthy period of time, during<br />

which the body needs less insulin. As a<br />

result, there is an increased feeling of satiety,<br />

with hunger pangs kept at bay for longer.<br />

Fibre can therefore play an effective role in<br />

weight management. In addition, fibre intake<br />

promotes the production of digestive juices,<br />

which have a stimulating effect on general<br />

intestinal movements. This means that the<br />

transit time of food in the digestive system<br />

is shortened, which can, in turn, reduce the<br />

risk of bloating and haemorrhoids.<br />

Recent studies show that dietary fibre can<br />

also help to prevent colon and prostate<br />

cancer because carcinogenic substances<br />

are diluted and harmful substances excreted<br />

more quickly. 3 One reason for this is that the<br />

body cannot break down the plant components<br />

of dietary fibre enzymatically, so they<br />

enter the colon undigested. Here, they serve<br />

as food for gut bacteria such as lactobacilli<br />

and bifidobacteria. These beneficial bacteria<br />

multiply, increase stool volume and thus<br />

help prevent constipation.<br />

A healthy intestinal microbiome is an essential prerequisite for a<br />

fully functioning immune system too. For instance, it helps to regulate<br />

inflammatory cascades in the body and forms a physical barrier<br />

against potential invaders such as pathogenic bacteria, viruses and<br />

parasites.<br />

Furthermore, in a healthy body, the fermentation of dietary fibre<br />

produces the short-chain fatty acids acetate, propionate and butyrate.<br />

These are partially absorbed and transported to the liver, where they<br />

inhibit the formation of cholesterol. The short-chain fatty acids also<br />

supply the cell membranes with energy and improve the absorption<br />

of minerals.<br />

Supporting health and wellbeing<br />

Taiyo, an expert in natural ingredients with added health value, has<br />

been pioneering fibre research for more than 20 years. The company<br />

develops and produces a wide variety of functional ingredients,<br />

including the 100 per cent natural dietary fibre Sunfiber ® . Designed to<br />

close the dietary fibre gap, this ingredient combines nutritional benefits<br />

with health-promoting properties. Sunfiber ® is a soluble prebiotic<br />

fibre that has been shown in numerous studies to help improve the<br />

activity and proliferation of beneficial probiotics in the gastrointestinal<br />

tract, which are essential for overall health and wellbeing. In addition,<br />

its fermentation rate is very slow, which means it does not trigger<br />

painful bloating, cramping or discomfort.<br />

Sunfiber ® not only contributes to healthy digestion, but also offers a<br />

range of clinically proven health benefits for the entire body. When<br />

consumed with a meal, it improves the absorption of minerals such<br />

as calcium and magnesium. 4 It also slows and reduces the absorption<br />

of fat, cholesterol and sugar. 5 Additionally, it has been shown in<br />

clinical studies to lower the glycaemic index, thus helping to stabilise<br />

blood sugar levels. For this reason, Sunfiber ® has been awarded a<br />

health claim by Canadian health authorities for reducing blood sugar<br />

levels by 20 per cent after a meal. 6<br />

Photo © : Shutterstock/Paisit Teeraphatsakool<br />

No. 1 April/May <strong>2022</strong><br />


Dietary fibres and overall well-being<br />

Low FODMAP diet-compatible<br />

Sunfiber ® is suitable for people who follow a low FODMAP diet, as<br />

well as for patients with irritable bowel syndrome (IBS). The term<br />

FODMAP stands for fermentable oligosaccharides, disaccharides,<br />

monosaccharides and polyols. These are poorly digestible shortchain<br />

carbohydrates such as lactose, fructose, sugar alcohols such<br />

as sorbitol, and many other indigestible carbohydrates found in<br />

fruits and vegetables. FODMAP components are fermented by the<br />

intestinal flora. This process is thought to trigger gastrointestinal<br />

symptoms such as bloating, diarrhoea, constipation and cramps<br />

in sensitive people. A clinical study published in 2010 reported the<br />

positive effect of a low FODMAP diet on the symptoms of conditions<br />

such as IBS. 7 A diet low in FODMAP compounds such as fibre is<br />

therefore often recommended for patients with digestive disorders.<br />

However, avoiding fibre compromises the foundation for good gut<br />

health. For these people, Sunfiber ® can bridge the nutritional gap<br />

by providing a soluble and prebiotic fibre that is compatible with a<br />

low FODMAP diet.<br />

Naturally certified<br />

Taiyo’s focus is on natural ingredients with added health value. Over<br />

the years, the company has established itself as a leading manufacturer<br />

of functional ingredients for the food and pharmaceutical industries.<br />

Naturalness plays a central part in this: Sunfiber ® is made from<br />

partially hydrolysed Indian guar gum (PHGG). The galactomannan<br />

fibre is colourless, odourless and tasteless, and is suitable for a variety<br />

of applications. It can be easily incorporated into existing recipes and<br />

is suitable for use in a wide range of foods and beverages, including<br />

bakery, dairy and confectionery, as well as meat and savoury products.<br />

Other potential applications include dietary supplements and<br />

instant or ready-to-drink beverages. The non-viscous guar bean fibre<br />

does not change the consistency or flavour of the products to which<br />

it is added.<br />

As the fibre is 100 per cent soluble, it dissolves completely in water<br />

and other hot and cold beverages, including smoothies. It has been<br />

used as a dietary supplement in clinical and enteral nutrition for<br />

several years, and is available in different qualities, depending on the<br />

desired application and requirement. Sunfiber ® is also pH, heat and<br />

thaw stable.<br />

It meets the dietary fibre definition of the FDA<br />

(US Food and Drug Administration), and a<br />

food or beverage product can be labelled<br />

as high-fibre if it contains at least 6 g of the<br />

ingredient per 100 g or at least 3 g per 100<br />

kcal. Taiyo also places the highest demands<br />

on the entire supply chain, with all seeds<br />

used being chemically untreated and GMOfree.<br />

Furthermore, no preservatives are used<br />

or added during processing. Sunfiber ® is ISO<br />

certified for its natural production process,<br />

as well as kosher and halal certified, and is<br />

suitable for vegetarian and vegan diets.<br />

References<br />

1<br />

Andrei, Mihai: WHO report: You should eat 25g of fiber every<br />

day – and you probably don’t. ZME Science, 15.01.2019,<br />

https://www.zmescience.com/science/who-report-fibers-<br />

14012019/#:%7E:text=A%20new%20report%20<br />

published%20by,swarm%20of%20other%20health%20<br />

issues. (accessed on 24.03.<strong>2022</strong>)<br />

2<br />

K. M. Neufeld, et al.: Reduced Anxiety-like Behavior and<br />

Central Neurochemical Change in Germ-free Mice. Neurogastroentereol<br />

Motil 23. no. 3 (March 2011): 255-64, e119<br />

3<br />

Diet and Cancer Report downloads: WCRF International,<br />

15.03.<strong>2022</strong>, https://www.wcrf.org/dietandcancer/<br />

resources-and-toolkits/ (accessed on 16.03.<strong>2022</strong>).<br />

4<br />

H. Hara, et al. Increases in Calcium Absorption with<br />

Ingestion of Soluble Dietary Fibre, Guar-Gum Hydrolysate,<br />

Depend on the Caecum in Partially Nephrectomised and<br />

Normal Rats. British Journal of Nutrition 76, 773–784<br />

(1996).<br />

5<br />

M.P. Kapoor, et al. Soluble Dietary Fibre Partially Hydrolysed<br />

Guar Gum Markedly Impacts on Postprandial Hyperglycaemia,<br />

Hyperlipidaemia and Incretins Metabolic<br />

Hormones Over Time in Healthy and Glucose Intolerant<br />

Subjects. Journal of Functional <strong>Foods</strong> 24, 207–220 (2016).<br />

6<br />

Confirmed by the Bureau of Nutritional Sciences, Food<br />

Directorate, Health Canada, Ottawa 25. April 2013.<br />

7<br />

P.R. Gibson and S.J. Shepherd. Evidence-Based Dietary<br />

Management of Functional Gastrointestinal Symptoms:<br />

The FODMAP Approach. J. Gastroenterology. Hepatic. 25(2),<br />

252–258 (2010).<br />

For more information, please contact<br />

Dr Stefan Siebrecht<br />

Managing Director at Taiyo GmbH<br />

s.siebrecht@taiyogmbh.com<br />

www.taiyogmbh.com<br />

14 No. 1 April/May <strong>2022</strong>

Microbiome<br />

Photo © : Madhouse<br />

Gut health 2.0 – The increasing role<br />

of the microbiome<br />

Diana Kalustova<br />

Super organ, superorganism, or the<br />

forgotten organ – the human microbiome<br />

is called by many names. And<br />

all of them reflect how important this<br />

“community of microorganisms” is for<br />

the natural everyday functioning of the<br />

human body. But what exactly is the<br />

microbiome? And what is it actually<br />

good for?<br />

The human microbiome consists of trillions<br />

of microorganisms. These include<br />

not only bacteria, but also fungi, parasites,<br />

and viruses. While many of the microorganisms<br />

have not yet been identified, scientists<br />

believe that well over 1,000 different ones<br />

live on us and in us. Each person has their<br />

individual fingerprint of the intestinal microbiota,<br />

determined by one’s DNA 1 . However,<br />

some microorganisms are found in each and<br />

every one of us.<br />

The intestine plays a unique role. By far, the most significant part of<br />

the human microbiome is found here. This is where a high microbial<br />

density meets the intestine-associated lymphoid tissue, which<br />

controls the entire body’s immune response.<br />

Microbes are generally not harmful to us. Rather, they are essential<br />

for maintaining good health. For example, they produce specific vitamins,<br />

break down our food to extract nutrients, teach our immune<br />

system to recognize dangerous invaders, and produce helpful antiinflammatory<br />

compounds that ward off other disease-causing<br />

microbes.<br />

It is not only experts who recognize the ever-increasing importance<br />

of the microbiome. Consumers also embrace the microbiome as an<br />

opportunity to maintain and improve their health. As a result, market<br />

research provider Fortune Business Insights predicts that the global<br />

digestive health market will grow at a compounded annual growth<br />

rate of 7.9 % to reach 71.95 billion US dollars by 2027. Several<br />

factors are driving this growth. One of them is the increasing incidence<br />

of digestive disorders, which are now seen in up to 40 % of the<br />

world’s population.<br />

No. 1 April/May <strong>2022</strong><br />


Microbiome<br />

It is now a generally accepted consensus that changes in the composition<br />

of our microbiome are associated with numerous diseases. This<br />

means that altering and enriching the microbiome can be used to<br />

maintain health and treat diseases. In particular, the gut microbiota<br />

critically intervenes in metabolism, immune system maturation, and<br />

the function of the central nervous system. This makes the microbiome<br />

a critical organ that influences the entire body.<br />

Gut Health 2.0 goes beyond digestion. Instead, it takes a holistic<br />

approach to health. Current research topics such as gut-immunity<br />

axis, gut-brain axis, gut-skin axis or gut-heart axis show the almost allencompassing<br />

significance of the human gut microbiome for human<br />

health. Axes represent the connections between the gut and individual<br />

human organs.<br />

An increasing number of studies demonstrate the incredible potential<br />

of the microbiome for various bodily functions. For example, it is<br />

now well established that a healthy microbiome is directly related to<br />

the skin’s health. As a multifunctional organ, it requires many micronutrients<br />

that are absorbed through the gut. Similarly, a dysfunctional<br />

microbiome is often closely related to metabolic diseases such as<br />

type 2 diabetes mellitus 2 .<br />

The microbiome also regulates the fitness of the immune system 3 .<br />

Healthy ageing and a longer life are also linked to the microbiome.<br />

A recent study 4 carried out in the United States shows that a high<br />

level of uniqueness and diversity of the microbiome is associated with<br />

increased survival. The microbiome-gut-brain axis takes on particular<br />

importance in studies. It is becoming clear that the composition and<br />

metabolism of the microbiome not only exert an important influence<br />

on mental disorders but also affect weight regulation.<br />


GUT MICRO-<br />

BIOTA<br />

G U T - S K<br />

HPA<br />

GUT-<br />

BRAIN-<br />

SKIN<br />

AXIS<br />

I N<br />


A X I S<br />


Even fitness and musculature are closely linked to the microbiome.<br />

For example, Swedish researchers 5 from the Karolinska Institute in<br />

Stockholm discovered in mice experiments that gut bacteria strongly<br />

influence normal skeletal muscle function. In any case, a holistic<br />

view of the body is essential for maintaining and improving health.<br />

The latest scientific findings show that a<br />

well-functioning, diverse microbiome has a<br />

central role as a control instrument for many<br />

aspects of the human body.<br />

Prebiotics, probiotics, synbiotics,<br />

and postbiotics:<br />

the supporters of the microbiome<br />

When something is as essential as the microbiome,<br />

we should do everything we can to<br />

keep it in good shape. Fortunately, the<br />

digestive system comprises several built-in<br />

supporters for this:<br />

Probiotics – the viable microorganisms that<br />

multiply in the gut and, in sufficient quantities,<br />

impart health benefits to the host.<br />

Prebiotics – the non-digestible food components<br />

that boost growth and activity of ba<br />

cteria in the colon. They also block the<br />

binding of harmful bacteria.<br />

Synbiotics – a combination of probiotics and<br />

prebiotics that synergistically combines the<br />

benefits of both.<br />

Postbiotics – byproducts of the fermentation<br />

process. These are soluble factors secreted<br />

by live bacteria or released after bacterial<br />

lysis and provide physiological benefits to the<br />

host. However, for many scientists, the definition<br />

of postbiotics was not clear enough. In<br />

2021, seeking clarity on what qualifies as a<br />

postbiotic, a panel of experts at the International<br />

Scientific Association of Probiotics and<br />

Prebiotics (ISAPP) sought a new definition 6 .<br />

They defined a postbiotic as a “preparation<br />

of inanimate microorganisms and/or their<br />

components that confers a health benefit on<br />

the host”.<br />

Prebiotics – much more than<br />

a trendy product<br />

The demand for advanced prebiotics that<br />

have no side effects and are intended<br />

to support specific areas in the body is<br />

increasing permanently. Certain prebiotics<br />

are particularly beneficial for the microbiome.<br />

They target particular bacteria, which<br />

produce a high amount of short-chain fatty<br />

acids. SCFAs do not have to be modified<br />

during digestion and absorbed directly by the<br />

body. According to current research, shortchain<br />

fatty acids serve as “food”, especially<br />

16 No. 1 April/May <strong>2022</strong>

Microbiome<br />

for those intestinal bacteria with a particular<br />

protective function. They can prevent inflammation<br />

in the body and protect against an<br />

attack by the human organism on the body’s<br />

cells, the cause of numerous autoimmune<br />

diseases such as multiple sclerosis, psoriasis,<br />

rheumatism, or allergies. In addition<br />

to strengthening the immune system, shortchain<br />

fatty acids could also help make bones<br />

more stable, alleviate joint inflammation,<br />

lower cholesterol levels or reduce appetite.<br />

An expanding range of candidate probiotic<br />

species and prebiotic substrates is<br />

emerging to address newly elucidated datadriven<br />

microbial niches and host targets.<br />

New variants of microbiome-modulating<br />

interventions are developing overlapping<br />

with, and adjacent to, the probiotic and<br />

prebiotic fields. Personalized nutrition and<br />

precision medicine are increasingly influencing<br />

the targeting and use of probiotics<br />

and pre biotics. As a result, the modulation<br />

of microbial signatures towards finding the<br />

appropriate “piece of the puzzle” to maintain the health of specific<br />

functions or to combat individual disease states is increasing.<br />

High-quality, tested synbiotics can be<br />

the best of both worlds<br />

Nowadays, live microorganisms are increasingly used with special<br />

dietary fibers to combine their health benefits. However, one must<br />

keep in mind that the combination of prebiotics and probiotics is<br />

not always beneficial, as not all of them go together. In any case, it<br />

is crucial to find a high-quality, tested combination. Besides, many<br />

people do not tolerate specific prebiotics well. Many soluble prebiotics<br />

are broken down too quickly by the intestinal flora, possibly<br />

leading to flatulence, bloating, and abdominal pain.<br />

Two examples of new-generation prebiotics that<br />

combine perfectly with probiotics<br />

Sunfiber ® is a water-soluble bean fiber derived from the guar bean.<br />

This is a galactomannan fiber (partially hydrolyzed guar gum, PHGG)<br />

that is very low viscous and non-gelling. It is a perfect ingredient for<br />

patients with irritable bowel syndrome and functional gastrointestinal<br />

disorders. Sunfiber ® is the first dietary fiber certified by Monash<br />

University as a low-FODMAP dietary fiber (fermentable oligosaccha-<br />

20%<br />

C<br />







Made in France<br />

+33(0) // contact@capsularis.com

Microbiome<br />

rides, disaccharides, monosaccharides, and polyols). The effect of<br />

Sunfiber ® on diet-related diseases has been demonstrated in more<br />

than 150 studies. For example, in a recent internal report 7 together<br />

with Probionova ® , the results for Lactobacillus spp. indicate that<br />

almost all microorganisms can actively grow in the presence of<br />

Sunfiber ® .<br />

MicrobiomeX ® is an example of a fruit extract with high flavonoid<br />

content and prebiotic effect. This first-in-class product combines<br />

active ingredients from Citrus Sinensis (Orange) and Citrus Paradisi<br />

(Grapefruit). The unique complex is specifically designed to positively<br />

alter the gut microbiome to support gut health and immune system,<br />

reduce intestinal inflammation and strengthen the gut barrier. MicrobiomeX<br />

® has been validated in multiple proprietary studies showing<br />

a dose-dependent beneficial effect with a daily intake ranging from<br />

250 to 500 mg. In addition, the significant shift in SCFA profile and<br />

the lower calprotectin levels observed suggest a decreased pathogen<br />

load in the gut.<br />

Probionova is one of the most innovative<br />

companies focusing on the microbiome by<br />

developing new probiotic applications. The<br />

young, future-oriented partner company of<br />

Vivatis ® maintains a leading scientific position<br />

in the research and development of<br />

new probiotics/synbiotics. With its in-depth<br />

experience, the company can select the<br />

best strain or an optimum synergy of the<br />

available strains to provide customers with<br />

the highest quality standards and customized<br />

offers. Probionova ® has specialized in<br />

responding to the most diverse wishes and<br />

requirements for probiotics products. The<br />

range extends from various unique probiotic<br />

strains to finished products that are good for<br />

the microbiome.<br />

Difference in Butyrate/total SCFA ratio<br />

after 12 weeks of intervention<br />

Butyrate & total SCFA ratio<br />

0.025<br />

0.02<br />

0.015<br />

0.01<br />

0.005<br />

0<br />

-0.005<br />

-0.01<br />

-0.015<br />

Intervention<br />

Placebo<br />

MicrobiomeX ®<br />

*<br />

*Significant effect on SCFA ratio<br />

after daily application of MicrobiomeX ®<br />

Today, customized product solutions are increasingly in demand<br />

for prebiotic and probiotic products instead of all-in-one products.<br />

They make it easier to meet the diverse requirements of the human<br />

organism, minimize side effects and provide targeted support for<br />

specific areas. The current state of research and product development<br />

is bringing into light a growing number of facts about the diversity<br />

of probiotic strains. They are designed or synergistically combined<br />

with high quality and concentration for the application and function.<br />

References<br />

1<br />

“Identifying personal microbiomes using metagenomics<br />

codes”, Eric A. Franzosa, Katherine Huang, James<br />

F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan JM<br />

Bohannan, Curtis Huttenhower,<br />

2<br />

“Arrhythmic Gut Microbiome Signatures Predict Risk of<br />

Type 2 Diabetes”<br />

3<br />

Schaupp L et al. Microbiota-induced type I interferons<br />

instruct a poised basal state of dendritic cells. Cell 2020<br />

Mai 06. doi: https://doi.org/10.1016/j.cell.2020.04.022<br />

4<br />

Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S.,<br />

Wiedrick, J., Lapidus, J., & Price, N. D. (2021). Gut microbiome<br />

patternreflects healthy ageing and predicts survival<br />

in humans. Nature metabolism, 3(2), 274-286.<br />

5<br />

“The gut microbiota influences skeletal muscle mass and<br />

function in mice”, Shawon Lahiri et al.; Science Translational<br />

Medicine, DOI: 10.1126/scitranslmed.aan5662<br />

6<br />

Aguilar-Toalá, J. E. et al. Postbiotics — when simplification<br />

fails to clarify. Nat. Rev. Gastroenterol. Hepatol.<br />

https://doi.org/10.1038/s41575-021-00521-6 (2021).<br />

7<br />

“Probionova report” (2020) Evaluation-of-the-prebioticpotential-of-Sunfiber<br />

For more information, please contact<br />

Diana Kalustova,<br />

Business Development Manager Nutraceuticals,<br />

Vivatis Pharma GmbH<br />

Hamburg, Germany<br />

18 No. 1 April/May <strong>2022</strong>

Bioactives for stress and sleep wellbeing<br />

Lactium ® , a natural bioactive for<br />

mental wellbeing praised by its consumers!<br />

How does stress affect<br />

our mental health?<br />

Stress is part of our modern life: 90 % of<br />

the global population regards itself as being<br />

stressed. Furthermore, WHO statistics were<br />

estimating a worldwide 264 million people<br />

to be affected by anxiety disorders. Those<br />

statistics were last estimated in 2017, way<br />

before covid-19 turned our lives upside<br />

down and the global demand for stress-relief<br />

aids sky-rocketed.<br />

95 % of the global population recognize that<br />

stress and anxiety have an impact on health.<br />

With the pandemics, awareness soared<br />

on how stress can impact mental health<br />

conditions including depression, anxiety,<br />

psychosis and post-traumatic stress disorder<br />

(PTSD).<br />

Lactium ® : a natural ingredient to help<br />

manage stress and sleep disorders<br />

Lactium ® is go-to solution for natural products<br />

lovers. With no addiction or side effects,<br />

this natural milk protein hydrolysate contains<br />

a bioactive peptide with relaxing properties<br />

called alpha-casozepine. Lactium ® acts as<br />

an anxiolytic with an affinity for the GABAA<br />

receptor, more specifically for its benzodiazepine<br />

site.<br />

9 clinical trials on more than 500 volunteers<br />

have already demonstrated Lactium ® efficacy<br />

on stress issues and sleep disturbances, with<br />

a recognition by the scientific community<br />

through several published articles.<br />

In 2021, those were completed by a<br />

consumer study to address a core objective<br />

for all our customers: consumer satisfaction.<br />

8 consumers in 10 are satisfied<br />

with Lactium ®<br />

Our latest study was performed on 300<br />

healthy volunteers, recruited in USA, France<br />

and China for their suffering from moderate<br />

stress and sleep disturbances. They<br />

received a 300 mg dose for 30 days and<br />

their feedbacks were recorded through validated<br />

questionnaires performed by Mérieux<br />

Nutrisciences.<br />

We were proud to receive results showing an<br />

overall 78 % satisfaction, quite evenly split in<br />

78 % for moderate stress and 77 % for sleep<br />

disturbances.<br />

More claims for Lactium ®<br />

As we’ll explain in our conference, this<br />

consumer study enables new claims on<br />

packaging or ad prints for our customers. It<br />

will complete the previously obtained 7 US<br />

FDA structure function claims and 2 South<br />

Korean claims.<br />

Happy consumers’ recognition is now adding<br />

to Lactium ® ’s solid scientific background for<br />

its efficacy on stress and sleep improvement,<br />

in a world where mental health has<br />

become so central to our lives. Incorporated<br />

for more than 20 years in over 300 products,<br />

Lactium ® provides a natural way to regain<br />

plain serenity!<br />

Please visit<br />

Ingredia at Vitafoods in Geneva<br />

May 10 – 12, <strong>2022</strong><br />

booth G100<br />

No. 1 April/May <strong>2022</strong><br />


Marine ingredients in sports nutrition<br />

A small revolution is underway in the world<br />

of lipids and marine ingredients<br />

Its name, Zooca Lipids or more precisely Calanus finmarchicus.<br />

This zooplankton is the primary biomass of the<br />

Arctic. From sustainable fisheries, it is harvested in Norway,<br />

above the Arctic circle and does not seem to fit into any<br />

box. Neither that of omega-3, nor that of krill oil. Let's dig<br />

into the story of this unique ingredient now distributed in<br />

France by Seanova: Zooca Lipids is about to revolutionize<br />

the sports industry.<br />

The tiny zooplankton Calanus finmarchicus is a dense pack of highperformance<br />

energy, utilized by the inhabitants of the Norwegian sea<br />

as their natural performance nutrition.<br />

The little auk, for instance, feed on Calanus finmarchicus during the<br />

short, arctic summer, to prepare for their long migrations during<br />

winter, where they often fly thousands of kilometres, all the way from<br />

Spitsbergen to Iceland and North- America.<br />

Why is Zooca Lipids, the natural oil from Calanus finmarchicus,<br />

such a powerful performance package of nutrients and energy? This<br />

natural oil is designed by nature to meet the<br />

needs of arctic creatures, who have very<br />

short time to prepare for harsh winter conditions<br />

and therefore depend on valuable<br />

nutrition. These benefits are now available to<br />

the athletes from the human world, as well.<br />

Let´s get a bit technical. What are some of<br />

the differences between Zooca Lipids<br />

and other fats? All lipids comprise a chain<br />

of carbon atoms bound to hydrogen atoms.<br />

Types of fat differ by the number of carbon<br />

atoms in the chain and the number and<br />

location of double bonds between them.<br />

Slight differences in structure may translate<br />

into critical differences in form and function.<br />

Fatty acids in krill oil are mostly bound to<br />

glycerol as phospholipids, whereas fatty<br />

acids in fish oils are present as triglyceri des.<br />

20 No. 1 April/May <strong>2022</strong>

Marine ingredients in sports nutrition<br />

When it is time to perform, you must rely on your heart! Zooca<br />

Lipids benefits cardiac performance by enhancing the pumping efficiency<br />

of the heart, a benefit associated with the ergogenic properties<br />

of policosanols. Zooca Lipids also significantly increased max<br />

heart rate! Together, these effects mean more oxygen and nutrients to<br />

muscles and other cells in the body. No wonder that Zooca Lipids<br />

gains reputation among high-level athletes.<br />

Fig. 1: Chemical differences of Zooca Lipids, shown as wax esters<br />

vs. conventional lipids.<br />

The uniqueness of Calanus finmarchicus-derived lipids is the<br />

chemi cal form of liquid wax esters (Fig. 1). Described chemi cally,<br />

they are fatty acids esterified to policosanols (often called fatty alcohols,<br />

FAOH) as monoesters. Wax esters are distinctly different from<br />

fat in any other marine (or terrestrial) oils in terms of chemistry, bioactivity,<br />

and health benefits.<br />

Zooca Lipids benefits muscle performance because it contains<br />

ergogenic policosanols that helps optimizing muscle function as well<br />

as nature´s most powerful antioxidant astaxanthin, which mitigates<br />

muscles soreness by reducing oxidative stress in muscle tissue. By<br />

increasing fatty acid oxidation, the muscle glycogen can be spared,<br />

delaying onset of muscle fatigue and enhance performance. Zooca<br />

Lipids is a potent mix of numerous omega-3 fatty acids, which<br />

promotes muscle protein synthesis, aiding restitution and preparing<br />

your body for new efforts.<br />

Zooca Lipids also benefits muscle restitution and soreness on<br />

several levels. The rare omega-3 fatty acid Stearidonic Acid gives an<br />

extra anti-inflammatory dimension. Together with the classic omega-3<br />

fatty acids EPA and DHA, Stearidonic Acid forms a potent anti-inflammatory<br />

trio which mitigates inflammation and lays a good foundation<br />

for optimal healing, partly by inhibiting omega-6 conversion and<br />

Stand H190<br />

Magnesium<br />

Innovation<br />

Magnesium Citrate Malate<br />

◆ Permitted and designed for nutritional supplements<br />

◆ Superior, clear solubility<br />

◆ Stable in high concentrated solutions<br />

◆ Pleasant taste

Marine ingredients in sports nutrition<br />

partly by being metabolized to anti-inflammatory Specialized Pro-<br />

Resolving Mediators, SPMs, and eicosanoids. Additionally, nature´s<br />

most powerful antioxidant astaxanthin reduces muscle-inflammation<br />

and soreness, leading to faster restitution and shorter time to the next<br />

full-intensity performance.<br />

Many athletes struggle to maintain their body in shape off season.<br />

This is the time of the season when you build the foundation for<br />

seasonal performance and muscles, heart, joints, and ligaments are<br />

exposed to extraordinary strain. During resting periods, it can be a<br />

challenge to maintain the body composition.<br />

Well, we have good news! Zooca Lipids benefits body composition<br />

and both fat reduction and muscle growth have been demonstrated<br />

in clinical trials.<br />

So, why is that so? Free fatty acid receptors are broadly regarded as<br />

nutrient sensors and are involved in the regulation of both inflammatory<br />

and metabolic processes. One of these is the GPR120 (also<br />

known as FFA4) receptor which is expressed in several tissues in the<br />

body, especially within the distal intestine and colon, as well as in<br />

adipose tissue and macrophages. This is a receptor for medium- and<br />

long-chain unsaturated fatty acids, including omega-3 fatty acids.<br />

Recent studies have shown GPR120 to play cardinal roles in metabolic<br />

disorders via modulation of gut hormone secretion and insulin<br />

sensitivity and body weight regulation.<br />

Whereas other dietary lipids claim their<br />

effects due to rapid absorption, Zooca<br />

Lipids explains it the other way around. The<br />

liquid wax esters from Zooca Lipids are<br />

slowly digested, resulting in delayed release<br />

of multiple bioactive molecules. The unique<br />

chemistry of these new and natural lipids<br />

allows them to withstand the first line of<br />

digestive enzymes, letting the lipids reach<br />

the distal part of the digestive tract without<br />

compromising the bioavailability of the fatty<br />

acids. When the liquid wax ester molecules<br />

ultimately are cleaved during digestion, the<br />

release of highly potent fatty acids activates<br />

GPR120 receptors present in the tissue and<br />

exert its effects. Whereas EPA and DHA are<br />

among the more potent of the common FAs<br />

on GPR120, Stearidonic acid, SDA, has<br />

recently been shown to be one of the most<br />

potent agonists on this central receptor. SDA<br />

is the predominant omega-3 fatty acid in<br />

Zooca Lipids!<br />

This receptor activation helps the body finetune<br />

metabolism of sugar and fat, making it<br />

easier to maintain the optimal body composition.<br />

Athletes report that it is easier to maintain<br />

the ideal body weight and body composition<br />

during off-season.<br />

If you think this was a bit complicated, we<br />

will make it easy for you. Summarized, what<br />

you need to know is that this natural powerpack<br />

of natural fats and nutrients from the<br />

zooplankton Calanus finmarchicus benefits<br />

muscle performance and restitution, heart<br />

pumping efficiency and body composition.<br />

So, do like the little auk: take Zooca Lipids<br />

with you on your sporting adventures!<br />

For more information and insight<br />

into clinical and preclinical results,<br />

please reach out to Seanova<br />

contact@seanova.fr<br />

www.seanova.fr<br />

22 No. 1 April/May <strong>2022</strong>

Ceramides for skin health<br />

Photo © : AdobeStock/Liubov_Levytska<br />

Ceramides: science supported<br />

lipids for skin health<br />

Lea Marchal<br />

As more and more information regarding<br />

ageing skin and its causes becomes<br />

available, consumer awareness continues<br />

to increase at an unprecedented<br />

high. The rise of Holistic Beauty<br />

observed for a few years, is a clear indication<br />

that consumers are now viewing<br />

lifestyle as an important factor in the<br />

appearance of their skin, including<br />

dietary interventions. To make the most<br />

of this opportunity in the Beauty-from-<br />

Within category, brands must develop<br />

food supplements based on ingredients<br />

with demonstrated efficacy, from<br />

natural origin, good for the consumers<br />

and more respectful of the environment.<br />

Seppic, designer of natural<br />

branded active ingredients for the<br />

nutricosmetics field, sheds light on a<br />

solution related to these major trends:<br />

phytoceramides.<br />

Ceramides: their role in skin health and youth<br />

The skin is a three-layer organ constituted of the hypodermis, the<br />

dermis, and the epidermis. The latter layer of the epidermis is called<br />

the stratum corneum and acts as a barrier against the exterior environment.<br />

The stratum corneum is made of skin cells, called corneocytes,<br />

and of lipids found in the intercellular spaces. The lipids are<br />

of different nature (cholesterol, free fatty acids,...) and ceramides are<br />

the major lipid species as they are represented at 50 % in the stratum<br />

corneum’s matrix. They have an essential and structuring role in skin<br />

health by supporting the skin barrier function and maintaining the<br />

water permeability of the skin.<br />

When skin reserves of water are preserved, the skin remains well<br />

moisturized and plump, preventing the apparition of cracks and<br />

scales. However, when we age, the skin becomes particularly thin<br />

and fragile with an impaired skin barrier. The stratum corneum of the<br />

skin, and more particularly its lipids, go through significant changes<br />

under the course of ageing, resulting in pigmentation spots, loss of<br />

elasticity, wrinkles and exacerbated dryness. These changes are now<br />

linked with a significant decrease in ceramides 1 .<br />

No. 1 April/May <strong>2022</strong><br />


Ceramides for skin health<br />

Opportunities to be leveraged<br />

in the Beauty-from-Within space<br />

A recent report from research firm Mordor<br />

Intelligence states that the global nutricosmetics<br />

market is estimated to register a<br />

CAGR of 8.05 % from 2021 to 2026 4 . The<br />

main factors driving the market are the rising<br />

consumer awareness regarding their skin<br />

problems, such as anti-ageing, wrinkles, hair<br />

loss, scalp problems, etc. These concerns<br />

are more and more associated with poor<br />

nutrition, making food supplements a go-to<br />

preventive beauty management practice.<br />

The preventive, holistic, and eco-conscious<br />

approach is delivering escalated growth of<br />

the skincare-from-within spacet, with offers<br />

that are based on clinically studied active<br />

ingredients.<br />

It is possible to deliver supplemental ceramides orally that provides the<br />

metabolites that are transported through the bloodstream to enable<br />

the skin to restore the ceramides levels in the stratum corneum.<br />

Ingestible ceramides to repair and<br />

strengthen the skin barrier<br />

Photo © : iStock/SrdjanPav<br />

Increasing usage of ceramides in cosmetics products provides now<br />

consistent evidence and awareness on topical ceramides efficiency<br />

in skin hydration and anti-ageing solutions. For the past decades, a<br />

strong scientific focus was observed to study ingestible ceramides,<br />

with evidence demonstrating that the oral use of ceramides is also<br />

highly effective at working to strengthen the skin barrier from within.<br />

A clinical trial on Ceramosides TM , a proprietary extract from Seppic<br />

that contains natural ceramides from wheat, reported significant<br />

improvement in skin moisturization by 16 %, skin elasticity by 18 %<br />

and skin wrinkles by 9 % compared to placebo in just 15 days 2 .<br />

Such a quick action is possible thanks to the composition of the<br />

ingredient in digalactosyl diglycerides (DGDG) combined with the<br />

presence of ceramides. Indeed, DGDG are natural emulsifiers shown<br />

to boost ceramides bioavailability and absorption, making ceramides<br />

building blocks available in the epidermis only 24 h after ingestion 3 .<br />

Ceramosides TM efficacy was also validated by the volunteers participating<br />

in the study, with 75 % of subjects noticing less pulling<br />

sensations<br />

In Europe, the demand for natural ingredients,<br />

influenced by the cosmetics industry,<br />

is visibly increasing and shaping the nutricosmetics<br />

offer. When sourcing ceramides,<br />

a close attention is to be paid on ingredients’<br />

origin, quality and traceability to be<br />

able to answer the consumers’ expectations.<br />

Phytoceramides are plant-based ceramides,<br />

found naturally in plants and grains,<br />

answering the consumer requirements for<br />

clean-label, non-GMO, organic and vegan<br />

solutions.<br />

A solution adapted to the needs of<br />

modern consumers<br />

The strong science behind oral supplementation<br />

with phytoceramides opens the<br />

door for new opportunities in skin beauty.<br />

Ceramosides is a perfectly adapted solution<br />

for modern consumers that are looking<br />

for new ways to address anti-ageing with<br />

demonstrated efficacy and quick action.<br />

Ceramosides offers full body coverage<br />

with results that can be perceived by the<br />

consumers, as it acts rapidly on the visible<br />

layer of the skin.<br />

Ceramosides is a natural oil, suitable<br />

with soft gel capsules and other innovative<br />

galenics such as shots and beverages<br />

thanks to its low dose that makes it suitable<br />

24 No. 1 April/May <strong>2022</strong>

Ceramides for skin health<br />

with stable emulsions. A hydrosoluble powder, obtained from the oil,<br />

also makes it suitable for a wide range of applications other than<br />

tablets and capsules. It can be easily incorporated in trendy dosage<br />

forms such as drinks, gummies, powder sticks or chocolate bites.<br />

Ceramosides also helps manufacturers to address the growing<br />

need for clean label ingredients. Free from additives and preservatives,<br />

Ceramosides is “100 % made in France”, from wheat sourced<br />

and processed in France. It has been granted a GRAS (Generally<br />

Recognized As Safe) status by an external expert panel and is fully<br />

suitable for vegan formulations. It is also available as organic certified<br />

offering an ideal solution for clean beauty products and answering<br />

the growing demand for organic certified supplements.<br />

8 consumers in 10 satisfied<br />

by the improvement<br />

on their stress and sleep<br />

With the increasing demand for nutricosmetics and anti-ageing<br />

ingestible solutions, phytoceramides from wheat represent a natural<br />

and effective solution backed by strong science. With Ceramosides TM ,<br />

Seppic intends to provide a powerful solution for innovative and<br />

attractive anti-ageing and moisturizing products. Scientific research<br />

will continue to demonstrate the potential of ceramides to promote<br />

healthy aging from within, enabling brands to develop appealing and<br />

tasty solutions to this fast-moving market.<br />

References<br />

1<br />

Jonca N. 2019. Ceramides metabolism and impaired epidermal barrier in cutaneous<br />

diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of<br />

v-O-acylceramides and its pathophysiological involvement in some forms of congenital<br />

ichthyoses. OCL 26: 17.<br />

2<br />

Bizot, V. et al. Improving Skin Hydration and Age-related Symptoms by Oral Administration<br />

of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study.<br />

Cosmetics 2017, 4, 37.<br />

3<br />

Ueda O, Hasegawa M, Kitamura S. Distribution in Skin of Ceramide after Oral Administration<br />

to Rats. Drug Metabolism and Pharmacokinetics. 2009;24(2):180-<br />

4<br />

https://www.mordorintelligence.com/industry-reports/nutricosmetics-market<br />

For more information, please contact<br />

Lea Marchal, food engineer<br />

Active Ingredients Product Manager -<br />

Nutrition Activity<br />

SEPPIC - Air Liquide Healthcare Specialty<br />

Ingredients, France<br />

www.seppic.com<br />

STRESS<br />


UNIQUE<br />

& NATURAL<br />


PROVEN<br />



Lactium® is a brand of Ingredia<br />

www.lactium.com<br />

No. 1 April/May <strong>2022</strong><br />


AMD and micronutrients<br />

Photo © : Adobestock/RFBSIP<br />

Age-related macular degeneration:<br />

Micronutrients for prevention and therapy<br />

Philipp Gebhardt<br />

The so-called “yellow spot” is an area in the centre of the<br />

retina where the photoreceptor cells are particularly densely<br />

arranged. It is the area of sharpest vision. The yellow spot<br />

(Latin “Macula lutea”) owes its name to its coloration, which<br />

is caused by high concentrations of carotenoids that are<br />

stored here and form a natural sunscreen. With increasing<br />

age, there is an increased deposit of metabolic waste<br />

pro ducts in the area of the macula. Together with the incident<br />

light, these deposits catalyse the formation of free radicals,<br />

which damage the photoreceptor cells and result in<br />

degeneration of the macula. For the prevention and treatment<br />

of age-related macular degeneration, certain carotenoids<br />

can improve the protection of the eyes from sunlight.<br />

Together with radical scavenging micronutrients, they can<br />

counteract the increasing damage to the photoreceptor cells.<br />

The lens of the eye bundles the light entering through the pupil at the<br />

back of the eye in such a way that a sharp image can form on the<br />

retina, which is recorded by the light-sensitive outer segments of the<br />

photoreceptor cells. In each eye, around 6 million “cone cells” are<br />

responsible for colour vision and around 120 million “rod cells” for<br />

twilight vision. Conscious, sharp vision is focused on a small area in the<br />

Vitreous body<br />

Lens<br />

Light<br />

Pupil<br />

Cornea<br />

Macula<br />

Optic nerve<br />

Retina<br />

Fig. 1: The light entering the pupil reaches the retina through the cornea,<br />

lens and vitreous body. The macula is a narrowly defined area in the rear,<br />

central area of the retina, through which the visual axis runs and in whose<br />

centre the distribution of light-sensitive sensory cells is at its greatest<br />

density.<br />

26 No. 1 April/May <strong>2022</strong>

AMD and micronutrients<br />

centre of the retina. The macula lutea (Latin<br />

for “yellow spot”) located here is a place with<br />

a particularly high density of photoreceptor<br />

cells (Fig. 1). The macula owes its yellow<br />

colour to the antioxidant and UV light filtering<br />

pigments lutein and zeaxanthin, which are<br />

contained in 1.000-fold higher concentrations<br />

in this area, compared to blood levels.<br />

About 100,000 cone photoreceptors with<br />

their outer segments are arranged in an<br />

area with a diameter of about 3 mm. Due to<br />

the effect of the concentrated light, around<br />

10,000 outer segments have to be renewed<br />

every night, which can only take place by a<br />

particularly intensive metabolism. Over time,<br />

insoluble degradation products are increasingly<br />

deposited and accumulate in the<br />

retina. A prominent representative of these<br />

residues from proteins and fats is called lipofuscin.<br />

In conjunction with UV light, lipofuscin<br />

catalyses the formation of free radicals.<br />

These are reactive oxygen species that<br />

damage surrounding tissue. With a particularly<br />

powerful radical scavenging system, the<br />

eye can defend itself against oxidative stress.<br />

With increasing age, the capacity of the antioxidative<br />

mechanisms decreases significantly.<br />

Age-related macular degeneration<br />

Age-related macular degeneration (AMD)<br />

is a disease of the retina and the choroid<br />

behind it. It usually appears in the form<br />

of visual disturbances, which appear in a<br />

bending of straight lines and in image failures<br />

in areas of the field of vision. Due to<br />

the increased accumulation of lipofuscin in<br />

the retina, the function of the visual cells is<br />

increasingly impaired and they eventually<br />

die off. The patchy disappearance of larger<br />

and larger areas (“geographic atrophy”), in<br />

the advanced stage, is a common cause of severe vision loss in old<br />

age. AMD comes in two forms. The so-called dry form of the disease<br />

accounts for about 80 % of cases. In this form, the ability to see is<br />

increasingly impaired in the central field of vision. In the wet form<br />

of the disease, flat vascular membranes also form under the retina,<br />

which tend to bleed. This can quickly lead to reading blindness. Due<br />

to the demographic development, the number of people affected by<br />

AMD is increasing significantly. In industrialized countries, the disease<br />

is the main cause of blindness in people over 50, followed by glaucoma<br />

and diabetic retinopathy. In Germany, about 12 % of the population<br />

are affected by early stages of AMD. In contrast, about 0.2%<br />

suffer a late form of macular degeneration characterized by choroidal<br />

neovascularization (new blood vessel formation in the retina) with<br />

fibrosis and formation of scars (in wet AMD) or geographic atrophy<br />

(in dry AMD). (1)<br />

The role of mitochondria in AMD<br />

Mitochondria are cell organelles enclosed by a double membrane<br />

in which oxidative phosphorylation, i. e. energy production using<br />

oxygen, takes place. As the “power plants of the cells”, mitochondria<br />

are responsible for generating more than 90% of the energy of<br />

metabolism in the form of adenosine triphosphate (ATP). Anaerobic<br />

processes can only produce 2 moles of ATP per mole of glucose.<br />

Aerobic energy production via the respiratory chain located in the<br />

mitochondria can generate 36 moles of ATP from one mole of<br />

glucose. The mitochondria therefore enable energy production to be<br />

18 times more efficient. Electrons are transferred from complex I and<br />

complex II of the respiratory chain to coenzyme Q10, which transfers<br />

them to complex III and via cytochrome C to complex IV. The electrons<br />

are brought to a lower energy level and the released energy is<br />

used to pump protons through the membrane to build up an electrochemical<br />

gradient. At complex IV, the electrons are transferred to<br />

oxygen to form water while consuming protons. The excess protons<br />

between the inner and outer membrane are broken down at complex<br />

V in order to regenerate ATP from ADP and phosphorus with the<br />

energy gained (Fig. 2).<br />

Reactions with oxygen also produce relevant amounts of oxygen radicals<br />

in the mitochondria. By transferring electrons to oxygen, superoxide<br />

radicals (O 2<br />

-) are formed in a magnitude of about two percent of<br />

the oxygen converted. Antioxidants such as coenzyme Q10 and anti-<br />

H +<br />

H +<br />

H +<br />

H +<br />

e<br />

Cyt C<br />

Complex<br />

Q10<br />

Complex<br />

e Complex Komplex Complex<br />

I e e<br />

e III<br />

IV<br />

V<br />

Complex<br />

II<br />

NADH NAD+<br />

O 2 2H 2 O<br />

Succinate Fumarate<br />

ADP+P ATP +H<br />

H +<br />

H +<br />

H +<br />

H + 2 O<br />

Fig. 2: The energy from our food is used via the respiratory chain to pump electrons across the inner mitochondrial membrane. At<br />

complex V, the proton gradient is broken down and the released energy is used to regenerate ATP, the cell's energy carrier.<br />

No. 1 April/May <strong>2022</strong><br />


AMD and micronutrients<br />

oxidant scavenging enzymes can normally neutralize the free radicals<br />

that are formed. If these protective mechanisms are impaired in their<br />

function or the amount of radicals formed exceeds the capacity of the<br />

antioxidative mechanisms, a dangerous state of crisis can develop,<br />

since damage to the respiratory chain complexes by free radicals<br />

further increases radical formation.<br />

In the case of AMD, there is an increased formation of free radicals<br />

primarily because a component of lipofuscin, the so-called A2E<br />

(N-retinylidene-N-retinylethanolamine) has an inhibitory effect on<br />

complex IV of the mitochondrial respiratory chain. A2E interrupts the<br />

flow of electrons via cytochrome C to complex IV. As a result, more<br />

electrons are transferred to oxygen at complex III and more superoxide<br />

radicals are formed, which damage proteins and membrane<br />

structures (Fig. 3). (2)<br />

In addition, coenzyme Q10 is a fat-soluble<br />

antioxidant that integrates into cellular<br />

and mitochondrial membrane structures<br />

and protects them from radical-induced<br />

damage. Coenzyme Q10 can regenerate<br />

other antioxidants such as vitamin C and<br />

vitamin E, which can also scavenge more<br />

free radicals. As a result, coenzyme Q10<br />

can protect the body's own structures from<br />

oxidative damage both directly and indirectly.<br />

Due to the increased oxidative stress,<br />

the retina has a relatively high concentration<br />

of coenzyme Q10. However, the levels<br />

decrease significantly with age (Fig. 4). Due<br />

to the decreasing coenzyme Q10 content,<br />

H + Superoxide radicals<br />

. H +<br />

O - 2<br />

.<br />

O - 2<br />

Complex<br />

Q10 e<br />

Q10<br />

Complex<br />

I e e<br />

e III<br />

Complex<br />

II<br />

NADH NAD+<br />

Succinate Fumarate<br />

H +<br />

.<br />

O - H + 2<br />

Complex<br />

IV<br />

N<br />

A2E<br />

OH<br />

Fig. 3: A component of lipofuscin, A2E inhibits the transfer of electrons in the mitochondrial respiratory chain. As a result, more<br />

electrons are transferred to oxygen. As a result, more oxygen radicals are formed, which damage membrane structures and respiratory<br />

chain complexes.<br />

Apart from a directly harmful effect of the oxygen radicals, the reduced<br />

ATP formation also has serious consequences that promote the further<br />

progression of the disease. In the area of the macula, the effect of<br />

the concentrated light requires an intensive repair capacity, which is<br />

particularly dependent on the availability of energy in the form of ATP.<br />

Impaired respiratory chain function ultimately results in a decreased<br />

ability to repair photodamage, further deteriorating vision.<br />

The influence of micronutrients<br />

on the pathogenesis of AMD<br />

There is currently no way to treat AMD causally. However, promising<br />

studies have shown that the progression of the disease can be<br />

stopped or at least slowed down by micronutrients that support antioxidant,<br />

anti-inflammatory and mitochondrial function. It could even<br />

be shown that micronutrients such as coenzyme Q10, acetyl-L-carnitine,<br />

omega-3 fatty acids and lutein can significantly improve vision<br />

in people with AMD.<br />

Coenzyme Q10<br />

Coenzyme Q10 (ubiquinone) is a quinone with a side chain<br />

consisting of 10 isoprene-units that transfers electrons between<br />

respiratory chain complexes and can enhance energy production.<br />

the antioxidant capacity of the tissues<br />

decreases, while the load from oxygen radicals<br />

increases. The positive effect of coenzyme<br />

Q10 supplementation was confirmed<br />

in a clinical study in which 106 participants<br />

Coenzyme Q10-content (nmol/g dry weight)<br />

60<br />

50<br />

40<br />

30<br />

20<br />

10<br />

0<br />

≤ 10 Years<br />

Content retina<br />

Content choroid<br />

≥ 90 Years<br />

Fig. 4: The coenzyme Q10 content of the retina<br />

and the choroid lying under the retina decreases<br />

with increasing age.<br />

28 No. 1 April/May <strong>2022</strong>

AMD and micronutrients<br />

with AMD received either a dietary supplement<br />

with acetyl-L-carnitine, omega-3 fatty<br />

acids and coenzyme Q10 or a placebo. While<br />

the visual performance in the placebo group<br />

deteriorated significantly in the following 12<br />

months, the participants in the verum group<br />

showed a significant improvement in visual<br />

functions. (3)<br />

Acetyl-L-Carnitine<br />

Carnitine is formed from the amino acids<br />

lysine and methionine and plays an essential<br />

role in the transport of long-chain fatty<br />

acids into the mitochondria. In its acetylated<br />

form, carnitine can more easily cross cell<br />

membranes and act inside the cell. Acetyl-<br />

L-carnitine improves mitochondrial energy<br />

production and reduces lipofuscin deposition<br />

by promoting fat metabolism. In AMD,<br />

supplementation together with coenzyme<br />

Q10 and omega-3 fatty acids can significantly<br />

improve visual parameters and slow<br />

down disease progression. (3)<br />

Omega-3 fatty acids<br />

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are<br />

polyunsaturated fatty acids that belong to the group of omega-3 fatty<br />

acids and form structural components of cell membranes. In the<br />

eye, high concentrations of DHA are stored in the outer segments of<br />

the photoreceptor cells. Omega-3 fatty acids have a beneficial effect<br />

on membrane fluidity and the function of membrane-associated<br />

proteins. This makes the membranes of the blood cells more flexible.<br />

They can pass through the narrow capillaries of our blood vessels<br />

more easily and improve tissue oxygenation. In AMD, supplementation<br />

with omega-3 fatty acids can significantly improve antioxidant<br />

capacity. A clinical study with 172 participants was also able to show<br />

a positive influence on the optical density of the macular pigment and<br />

a significantly beneficial effect on blood lipid levels. (4)<br />

Lutein<br />

The carotenoids lutein and zeaxanthin are stored in high concentrations<br />

in the macula. They filter out large portions of the high-energy<br />

blue-violet light and serve as “natural sunglasses” that mitigate the<br />

harmful effects of the radiation. With a reduced carotenoid content<br />

in the macula, there is both an increased harmful effect of the lipofuscin<br />

deposits and increased exposure to light, which particularly<br />

Expert in health ingredients and innovative formulations<br />

www.seanova.fr<br />

contact@seanova.fr +33(0)2 98 50 41 60<br />

//<br />

No. 1 April/May <strong>2022</strong><br />


AMD and micronutrients<br />

affects blue-sensitive photoreceptor cells.<br />

With AMD, the perception of blue and<br />

violet is therefore the first to fail. The colour<br />

impression shifts towards grey to brown. It<br />

could be shown that low carotenoid concentrations<br />

in the macula are causally involved<br />

in the development of AMD and can predict<br />

corresponding eye damage with lead times<br />

of around 20 years. (5) The macular pigment<br />

lutein must be ingested with food because<br />

the body cannot synthesize it from other<br />

carotenoids such as β-carotene. The structurally<br />

related carotenoid zeaxanthin, on the<br />

other hand, can be synthesized from lutein<br />

if required. A recent review that evaluated<br />

data from more than 900 participants with<br />

AMD showed significant improvements in<br />

visual acuity and contrast sensitivity. Accordingly,<br />

supplementation of lutein increases<br />

the pigment content of the macula in a dosedependent<br />

manner. (6)<br />

Improving bioavailability through<br />

phospholipids<br />

Coenzyme Q10 and lutein are not soluble in<br />

water and only have a limited solubility in fats.<br />

The active ingredients tend to agglomerate<br />

in the gastrointestinal tract when supplemented<br />

in powder capsule or tablet form.<br />

As a result, only molecules on the surface<br />

of the agglomerates can be absorbed by the<br />

enterocytes of the small intestine, while the<br />

majority pass through the body unchanged.<br />

However, a significant improvement in bioavailability<br />

can be achieved by forming emulsions<br />

with natural phospholipids (lecithin), in<br />

which the active ingredients are present in<br />

small droplets coated with lecithin (Fig. 5).<br />

Lecithin is also a natural component of bile<br />

that facilitates the absorption of dietary fats<br />

and fat-soluble nutrients. A crossover study<br />

was able to show that the bioavailability of<br />

coenzyme Q10 can be improved by a factor<br />

of five with an appropriate formulation. (7)<br />

For more information, please contact<br />

Philipp Gebhardt<br />

65779 Kelkheim, Germany<br />

p.gebhardt@mitotherapie.de<br />

Conclusion<br />

7<br />

2<br />

1<br />

Fig. 5: Improvement of the bioavailability of<br />

coenzyme Q10 by formulation with lecithin: Coenzyme<br />

Q10 is packaged in ultra-small droplets<br />

with natural phospholipids [1]. The absorption<br />

of the coenzyme begins in the mouth via the oral<br />

mucosa [2]. The lecithin shell protects the active<br />

ingredients from the harsh environment of the<br />

stomach [3]. Lecithin is a natural component of<br />

bile that facilitates the digestion of dietary fats<br />

and fat-soluble nutrients [4]. The prepackaged<br />

coenzyme Q10 can be absorbed much better<br />

by the enterocytes of the small intestine [5]. In<br />

the enterocytes, fat-soluble nutrients are packed<br />

into chylomicrons or lipoproteins with the help<br />

of phospholipids [6]. For systemic distribution,<br />

the coenzyme Q10-containing chylomicrons are<br />

released into the lymph and the coenzyme Q10-<br />

containing lipoproteins into the blood [7].<br />

The development of age-related macular<br />

degeneration is promoted by a low carotenoid<br />

content in the macula. The carotenoid lutein<br />

can improve the eye’s natural sun protection<br />

and thus reduce the harmful effects of light<br />

and the light-induced formation of oxygen<br />

radicals. Antioxidants such as coenzyme<br />

Q10 can increase the neutralization capacity<br />

for oxygen radicals and help to protect the<br />

eyes. In addition to its antioxidant effect,<br />

coenzyme Q10 is characterized by the fact<br />

that it improves the function of the respiratory<br />

chain and contributes to energy production.<br />

In addition to a low intake of lutein with<br />

food, smoking and high blood pressure are<br />

considered risk factors for AMD. (8) In addition,<br />

increased concentrations of the toxic<br />

metabolic intermediate homocysteine and<br />

reduced vitamin B12 levels have also been<br />

identified as risk factors. (9)<br />

3<br />

Enterozyte<br />

6<br />

5<br />

4<br />

References<br />

(1) Brandl, C., Stark, K. J., Wintergerst, M., Heinemann,<br />

M., Heid, I. M., & Finger, R. P. (2016). Epidemiologie der<br />

altersbedingten Makuladegeneration. Der Ophthalmologe,<br />

113(9), 735-745.<br />

(2) Suter, M., Remé, C., Grimm, C., Wenzel, A., Jättela, M.,<br />

Esser, P., ... & Richter, C. (2000). Age-related macular<br />

degeneration the lipofuscin componentn-retinyl-n-retinylidene<br />

ethanolamine detaches proapoptotic proteins<br />

from mitochondria and induces apoptosis in mammalian<br />

retinal pigment epithelial cells. Journal of Biological<br />

Chemistry, 275(50), 39625-39630.<br />

(3) Feher, J., Kovacs, B., Kovacs, I., Schveoller, M., Papale,<br />

A., & Gabrieli, C. B. (2005). Improvement of visual functions<br />

and fundus alterations in early age-related macular<br />

degeneration treated with a combination of acetyl-L-carnitine,<br />

n-3 fatty acids, and coenzyme Q10. Ophthalmologica,<br />

219(3), 154-166.<br />

(4) Arnold, C., Winter, L., Fröhlich, K., Jentsch, S.,<br />

Daw czynski, J., Jahreis, G., & Böhm, V. (2013). Macular<br />

xanthophylls and ω-3 long-chain polyunsaturated fatty<br />

acids in age-related macular degeneration: a randomized<br />

trial. JAMA ophthalmology, 131(5), 564-572.<br />

(5) Arunkumar, R., Calvo, C. M., Conrady, C. D., & Bernstein,<br />

P. S. (2018). What do we know about the macular<br />

pigment in AMD: the past, the present, and the future.<br />

Eye, 32(5), 992-1004.<br />

(6) Feng, L., Nie, K., Jiang, H., & Fan, W. (2019). Effects of<br />

lutein supplementation in age-related macular degeneration.<br />

PloS one, 14(12).<br />

(7) Wajda, R., Zirkel, J., & Schaffer, T. (2007). Increase of<br />

bioavailability of coenzyme Q10 and vitamin E. Journal of<br />

medicinal food, 10(4), 731-734.<br />

(8) Hyman, L., & Neborsky, R. (2002). Risk factors for agerelated<br />

macular degeneration: an update. Current opinion<br />

in ophthalmology, 13(3), 171-175.<br />

(9) Rochtchina, E., Wang, J. J., Flood, V. M., & Mitchell, P.<br />

(2007). Elevated serum homocysteine, low serum vitamin<br />

B12, folate, and age-related macular degeneration: the<br />

Blue Mountains Eye Study. American journal of ophthalmology,<br />

143(2), 344-346.<br />

30 No. 1 April/May <strong>2022</strong>

Hacking the food supply:<br />

Can we synthesize a more<br />

Sustainable Future?<br />

What does this mean for you, your career,<br />

and your organization?<br />

Attend IFT FIRST: Annual Event and Expo to discuss and debate<br />

this topic and others including questions around food safety,<br />

health & nutrition, technology, and education.<br />

July 10–13, <strong>2022</strong><br />

McCormick Place | Chicago, IL<br />

Innovation: New scientific programming to<br />

explore potential promise and pitfalls of cutting-edge<br />

innovation in food<br />

Insights: Learn the latest trends, emerging<br />

ingredients, and business strategies to move work,<br />

research, and business forward<br />

Connect: Engaging and fun networking<br />

opportunities with familiar faces and new ones<br />

Registration is now open<br />

Secure your spot today!<br />

Visit iftevent.org for more information.

Minerals in sports nutrition<br />

Photo © : iStock/Neustockimage<br />

Minerals in sports nutrition<br />

Apart from the macronutrients fats, carbohydrates and<br />

proteins an adequate supply of minerals is essential for the<br />

health and performance of athletes. Calcium, Potassium and<br />

Magnesium are among the best-known minerals, but also<br />

trace elements like Iron and Zinc are of high importance –<br />

especially for athletes. These minerals and trace elements<br />

ensure optimal functioning of muscles and nerves, besides<br />

they are involved in the formation of bones and in the regulation<br />

of blood pressure. 1<br />

Athletes have an increased need for minerals<br />

and trace elements due to a higher demand<br />

on the metabolism and the loss through<br />

perspiration. The most common deficient<br />

minerals are Sodium, Calcium, Magnesium,<br />

Potassium as well as Iron, Zinc. 2 Depending<br />

on the type of sport, the intensity and extent<br />

of exercise, and individual factors (e. g. nutritional<br />

behaviour, sweat rate and composi-<br />

Element<br />

Nutrient<br />

Reference<br />

Values 4 (NRV)<br />

Mineral Concentration<br />

in Sweat with approx. 60 min<br />

of physical exercise 5, 6<br />

Functions within the Body<br />

Calcium 800 mg 11–36 mg/l Muscle function – regulation of contraction,<br />

energy metabolism<br />

Magnesium 375 mg 0.84–2.36 mg/l Maintenance of bones, muscle function – counterpart<br />

to Calcium, protein synthesis, energy<br />

metabolism, decrease of tiredness/fatigue<br />

Potassium 2000 mg 167–236 mg/l Blood pressure, muscle function<br />

Iron 14 mg 0.56–1.12 mg/l Formation of red blood cells/haemoglobin,<br />

oxygen transport, reduction of tiredness/fatigue<br />

Zinc 10 mg 0.92–1.23 mg/l Cell protection from oxidative stress, immune<br />

system, metabolism of macronutrients,<br />

protein synthesis<br />

32 No. 1 April/May <strong>2022</strong>

Minerals in sports nutrition<br />

tion), athletes may be at increased risk of<br />

suboptimal supply of some micronutrients. 3<br />

In addition to the daily diet, dietary supplements<br />

can help to ensure the supply of all<br />

important minerals and trace elements.<br />

The detection of mineral deficiency symptoms<br />

is still rather difficult. 1 Usually such<br />

symptoms are unspecific, e. g. general indisposition<br />

or fatigue. As minerals are fixed with<br />

liquid compartments, every loss of water<br />

is also a loss of minerals. 1 Especially for<br />

athletes the replenishment of mineral losses<br />

is of special importance.<br />

Nutrition is an important tool in terms of<br />

performance optimisation and regeneration.<br />

There is no perfect formula to satisfy<br />

every athlete’s personal nutritional needs, as<br />

every sport has its own specific strain on the<br />

human body and every athlete is physically<br />

different. 2<br />

Sports nutrition was a niche sector in the past<br />

and has developed into a growth market. At<br />

the same time, customers became more<br />

diverse. It formerly used to be elite athletes<br />

who would focus nutrition, whereas now it<br />

can be the office worker commuting by bike,<br />

who has an interest in nutrition in order to<br />

support a healthy lifestyle. 7<br />

Power sports<br />

The category “power sports” can be divided into three main areas:<br />

maximum strength, quickness and strength endurance. The goal of<br />

power sports is to set free the highest amount of muscular power<br />

possible over a usually short duration. 1<br />

In addition to the macronutrients, mineral salts are a key factor for<br />

successful competition. Training sessions are not as long as in endurance<br />

sport, a remineralisation during training is not required. 8 Nevertheless,<br />

minerals as important micronutrients ensure that the muscle<br />

can be used up to its full potential, supporting muscle contraction,<br />

energy metabolism as well as the nervous system. 9<br />

Popular sports<br />

The category “popular sports” summarises physically active people,<br />

exercising to keep a certain level of fitness or as a hobby. The category<br />

is nondependent on the type of exercise. As the strains are not<br />

as demanding as those of competing athletes, a coordinated nutrition<br />

is usually not of high importance. Though, nutritional considerations<br />

are not irrelevant for them, as they support the build-up of power and<br />

stamina.<br />

As popular sports are physically demanding as well, sweat is lost<br />

during performance. Compared to competing athletes, “untrained<br />

people” have a different composition of the sweat, due to the fact, that<br />

the organism is not as used to intensive strains. The sweat contains<br />

more minerals as opposed to trained athletes, who are able to recover<br />

some minerals with their sweat glands and whose sweat contains less<br />

minerals in general. 1<br />

Endurance athletes<br />

The main goal of an endurance athlete is to<br />

hold the highest possible power for a specific<br />

period. The need of macronutrients, especially<br />

carbohydrates, is high due to of the<br />

increased amounts of energy, these athletes<br />

transform over a long period.<br />

Besides macronutrients, hydration is an<br />

important factor, endurance athletes should<br />

focus on. As muscle activity produces heat,<br />

the body uses the endothermic effect of the<br />

evaporation of the sweat in order to prevent<br />

the danger of overheating. Perspiration leads<br />

to an increased need for water and minerals,<br />

as sweat contains about 2–3 g of mineral<br />

salts per litre. 1 However, after long lasting<br />

exercises with intensive losses of sweat and<br />

thus minerals, it is generally recommended<br />

to replenish the lost minerals. 8<br />

Photo © : iStock/GlobalStock<br />

No. 1 April/May <strong>2022</strong><br />


Minerals in sports nutrition<br />

The function of minerals for athletes<br />

Calcium<br />

Calcium is a bivalent metal and corresponds to 1.5 % of the human<br />

bodyweight. 1 About 99 % of the amount is bound in bones and teeth.<br />

Together with phosphate, it is of high importance for their stability. 10<br />

The body uses the Calcium stores in the bones as a reservoir. Additionally,<br />

Calcium plays a key role in regulating various processes in<br />

neural transmission, as well as in the haemostasis, the stabilisation<br />

of cell membranes and the regulation of metabolism-processes. 9<br />

Furthermore, Calcium is responsible for all muscle contractions via<br />

the transmission of stimuli from the neural system to the muscle cell.<br />

A deficiency has an impact on the maximum tension capacity during<br />

strength training. Symptoms like a rising excitability of the muscle or<br />

cramps can be the consequence. 10<br />

Magnesium<br />

Since Magnesium is an activator of all reactions involving ATP<br />

(Adenosine Triphosphate), it is of high importance to physical<br />

performance. 1 The body of a 70 kg adult, contains 20–28 grams of<br />

Magnesium. In combination with Calcium, about 60 % of Magnesium<br />

is stored in the bones as hydroxyapatite. The remaining Magnesium<br />

can be found to 35 % in intracellular and to 5 % in extracellular<br />

solution. 10<br />

The Magnesium is used for growth and stabilization of bones. Additional<br />

functions are to be an essential cofactor of more than 300<br />

enzymes in the metabolism, support of muscle contraction, synthesis<br />

of proteins and nucleic acids as well as the release of hormones<br />

and neurotransmitters. Magnesium is a catalyzer for ATP-dependant<br />

enzyme systems and therefore part of the energy-metabo lism.<br />

Together with Potassium, Calcium and Sodium it is necessary for<br />

the transition of chemical into mechanical energy in the muscles.<br />

Magnesium is the counterpart of Calcium. While Calcium is responsible<br />

for passing on the stimulus to the muscle, Magnesium closes<br />

the ion channel again and prevents the continuous tensioning of the<br />

muscle. 1<br />

A deficiency (hypomagnesemia) hampers the appropriate relaxation<br />

mechanism of Magnesium and can cause spasms and tensions<br />

in muscles. Other signs and symptoms of hypomagnesemia<br />

include anything from mild tremors and generalized weakness to<br />

vascular spasms of heart and blood vessels and cardiac arrhythmia.<br />

Hypomagnesemia can be innate or occur due to reduced resorption,<br />

increased excretion or medication but in the most common<br />

cases due to insufficient supply. 11 In Germany alone, 26 % of men<br />

and 29 % of women do not reach the daily amount of magnesium<br />

recommended by the D-A-CH reference values. 11 In addition to a<br />

diet low in Magnesium, sporting activity is also a factor that can lead<br />

to an undersupply. During intensive sporting activity, a high proportion<br />

of Magnesium is lost, especially through sweat. 2 This makes a<br />

balanced Magnesium intake vital, especially for athletes.<br />

Potassium<br />

More than 90 % of Potassium in the human<br />

organism is located in the intracellular<br />

medium. 10 As the most important intracellular<br />

cation, Potassium is responsible for<br />

the maintenance of the intracellular osmotic<br />

pressure and it is involved in many metabolic<br />

processes as well. 12<br />

Symptoms of a Potassium deficiency are<br />

diverse. They vary from apathy, to decreased<br />

neuromuscular stimulation, cramps, gastrointestinal<br />

complaints, tachycardia, kidney<br />

damage, decreased glucose tolerance and<br />

1, 8, 12, 13, 14<br />

cardiac dysfunctions.<br />

Athletes can be at risk of Potassium deficiency<br />

for multiple reasons. For once Potassium<br />

is closely bound to the glycogen<br />

metabolism. During the metabolisation of<br />

glycogen, Potassium is set free, which is<br />

in turn needed for the resynthesis. 1 Moreover,<br />

Potassium is lost through increased<br />

sweating during long strains. 10,12 Especially<br />

endurance athletes prone to heavy perspiration<br />

should therefore be advised to consume<br />

additional Potassium. 15<br />

Iron<br />

Iron is the most important trace element in<br />

the human organism, with body stores of<br />

3–5 g. 10 Nutritional Iron is available as haem<br />

Iron and ionised Iron, respectively Fe (II) and<br />

Fe (III). 16<br />

Iron is a central component of red blood<br />

cells. Without Iron, the blood could not transport<br />

oxygen and supply the muscles. In the<br />

muscle, it is present as the central component<br />

of myoglobin in order to transport<br />

oxygen into the heart and skeletal muscle<br />

tissue. It acts as an antioxidant and is an<br />

important component of the electron transport<br />

chain for the production of ATP. 17<br />

Iron deficiency is associated with altered<br />

metabolic processes. Physical manifestations<br />

of an iron deficiency are e. g. anaemia,<br />

fatigue and weakness, pale skin, brittle<br />

nails. In the field of sports nutrition, Iron is<br />

regarded as one of the most critical micronutrients<br />

18 and counterintuitively iron deficiency<br />

is one of the most commonly diag-<br />

34 No. 1 April/May <strong>2022</strong>

Minerals in sports nutrition<br />

nosed mineral deficiencies in sports medicine.<br />

19 The high incidence of Iron depletion<br />

among athletes is usually linked to an inadequate<br />

energy intake. Factors affecting the<br />

Iron status are e. g. vegetarian diet, periods<br />

of rapid growth, training at high altitudes,<br />

increased Iron losses in sweat, and other<br />

body fluids. 19<br />

Iron is involved in the transport and metabolism<br />

of oxygen for aerobic energy production<br />

during endurance exercise. Athletes<br />

with suboptimal Iron status may experience<br />

reduced exercise capacity and impaired<br />

sports performance. 20 Once an iron deficiency<br />

has developed, the recovering can<br />

take months. 21 The Iron supplementation of<br />

iron-deficient athletes improves blood biochemical<br />

measures and iron status on the<br />

one hand, on the other hand it also increases<br />

work capacity as evidenced by increasing<br />

oxygen uptake, reduces the heart rate and<br />

decreases the lactate concentration during<br />

exercise. 18<br />

utes to the protein synthesis and is involved<br />

in the adaptation process of training stimuli,<br />

process of growth, wound healing and<br />

general functions of the immune system. 19<br />

However, a relatively low Zinc status has<br />

been observed in many athletes, which is<br />

caused by an insufficient intake with food<br />

and increased losses through urine and<br />

sweat. Continuously high exercise volumes<br />

and additional strains induced through<br />

the participation in competitions lead to<br />

increased Zinc losses. As a result, active<br />

athletes generally have higher Zinc requirements.<br />

Especially at risk are high endurance<br />

athletes, athletes using a hypocaloric<br />

diet in order to compete in certain weight<br />

classes and vegetarian or vegan athletes. If<br />

an increased Zinc intake cannot be achieved<br />

through an adjusted diet, supplementation is<br />

1, 10, 19, 22<br />

a sensible remedy.<br />

How to find the best mineral salt<br />

The choice to the anionic part of a mineral<br />

salt is of particular importance. Beside<br />

physi cal and chemical properties like solubility,<br />

pH-value and taste, anions have also<br />

an important influence on the bioavailability<br />

Bioactive Collagen Peptides stimulate<br />

the body's own collagen metabolism<br />

Zinc<br />

Zinc is a trace element with a relatively<br />

small storage capacity in the human body,<br />

compared to Iron. Hence, large quantities of<br />

Zinc cannot be mobilised if higher requirements<br />

arise. Therefore, a constant intake of<br />

Zinc through food or food supplements is<br />

indispensable. 10<br />

Zinc fulfils catalytic, structural and regulatory<br />

functions in the organism and is<br />

involved in more than 300 metalloenzymes,<br />

as a co-factor or as an integral part. As Zincdependent<br />

enzymes are present in all metabolic<br />

areas. It is also involved in almost all<br />

life processes and thus also in antioxidative<br />

mechanisms. Moreover, Zinc itself has an<br />

antioxidative effect, since it is able to bind<br />

to various molecules and to protect them<br />

against oxidative damage. A Zinc deficiency<br />

manifests in a reduced immunological<br />

defence, dermatitis, hair loss, and delayed<br />

wound healing. 10<br />

Body Toning<br />


Always in Shape<br />

,P- ........ ,,,<br />

Bone Health<br />

FORTI BONE ®<br />

Collagen Matrix Stimulation<br />

,P- ........ ,,,,,,_<br />

Joint Health<br />


The Joint Health Revolution<br />

,P- ,,,,,,_<br />

Beauty from Within<br />

VERISO<br />

Beauty from Within<br />

,P- ........ ,,,,,,_<br />

Immune Health<br />


Advancing Immune Health<br />

,,,,,,_<br />

Connective Tissue<br />

Improvement<br />


For Connective Strength<br />

,;P ........ __,<br />

Zinc plays a particular part in the nutrition of<br />

athletes. It is of high importance for physi cal<br />

performance as a part of the muscular<br />

enzyme system. Furthermore, Zinc contrib-<br />

No. 1 April/May <strong>2022</strong><br />

········· .<br />

. ..........<br />

·:-:::-:•..<br />

•<br />

Trusted Science<br />

••••••••• ®<br />




Ra.:<br />

[!] I: •<br />

bit.ly/3f8L 1 CG<br />


Uferstr. 7<br />

69412 Eberbach<br />

Germany<br />

www.gelita.com<br />

Gi:LIT-\<br />

Improving Quality of Life

Minerals in sports nutrition<br />

and the compatibility. Organic acids promote the absorption of certain cations, like Magnesium,<br />

Calcium, and Iron. Citrate, malate and fumarate are part of the citric acid cycle within<br />

the human metabolic pathway and are therefore easy to digest. Fully reacted mineral salts<br />

from amino acids like bisglycinates are known for an excellent bioavailability and are well<br />

tolerated.<br />

Mineral Salts of Dr. Paul Lohmann ® are especially designed for the use in food supplements.<br />

They fulfill the purity parameters for ready to use food supplements already in the raw material<br />

state. These quality parameters were decreed by the European Commission to ensure the<br />

constantly high quality and purity of food supplements. Different techniques of particle size<br />

engineering like micronization, granulation or microencapsulation is a strength of Dr. Paul<br />

Lohmann ® . Tailor-made product developments and product adaptions are carried out in close<br />

collaboration with the customers.<br />

Best performer in sports nutrition<br />

Mineral Salt Soluble Insoluble<br />

Calcium<br />

Magnesium<br />

Iron<br />

Zinc<br />

Potassium<br />

Dr. Paul Lohmann GmbH & Co. KGaA<br />

Hauptstr. 2<br />

31860 Emmerthal/Germany<br />

sales@lohmann4minerals.com<br />

www.lohmann4minerals.com<br />

Calcium Bisglycinate<br />

Calcium Lactate PLUS<br />

Magnesium Bisglycinate<br />

Magnesium Citrate<br />

Magnesium Citrate Malate*<br />

Magnesium Gluconate<br />

Ferrous Bisglycinate<br />

Ferrous Gluconate<br />

Ferrous Sulfate<br />

Zinc Bisglycinate<br />

Zinc Ascorbate*<br />

Potassium Magnesium Citrate<br />

Potassium Citrate<br />

*Only permitted for food supplements in Europe<br />

For more information, please contact<br />

Calcium Citrate<br />

Calcium Citrate Malate<br />

Magnesium Carbonate<br />

Magnesium Lactate<br />

Magnesium Malate*<br />

Magnesium Phosphate<br />

Ferrous Fumarate<br />

Ferric Pyrophosphate<br />

Zinc Citrate<br />

Zinc Malate*<br />

Zinc Sulfate<br />

-<br />

References<br />

1<br />

Baron, D., & Berg, A. (2005). Optimale Ernährung des<br />

Sportlers. Stuttgart: S. Hirzel Verlag.<br />

2<br />

Neumann, G. (2016). Ernährung im Sport. Aachen:<br />

Meyer & Meyer Verlag.<br />

3<br />

Sawka Mn, Burke Lm, Eichner Er, Maughan Rj, Montain Sj,<br />

Stachenfeld Ns. American College of Sports Medicine position<br />

stand. Exercise and fluid replacement. Med Sci Sports<br />

Exerc. 2007; 39: 377-390.<br />

4<br />

Regulation (EU) No 1169/2011 of the European Parliament<br />

and of the Council of 25 October 2011 on the provision of<br />

food information to consumers<br />

5<br />

Montain Sj, Cheuvront Sn, Lukaski Hc. Sweat mineralelement<br />

responses during 7 h of exercise-heat stress. Int<br />

J Sport Nutr Exerc Metab. 2007; 17: 574-582. doi:10.1123/<br />

ijsnem.17.6.574<br />

6<br />

Chinevere Td, Kenefick Rw, Cheuvront Sn, Lukaski Hc,<br />

Sawka Mn. Effect of heat acclimation on sweat minerals.<br />

Med Sci Sports Exerc. 2008; 40: 886-891. doi:10.1249/<br />

MSS.0b013e3181641c04<br />

7<br />

Carey, A. (2017). A healthy market - the rise and rise of<br />

sports nutrition. International Journal of Nutraceuticals,<br />

Functional <strong>Foods</strong> and Health Ingredients, vol. 28, issue 6,<br />

S. 6-7.<br />

8<br />

Vollmer, G., & al., e. (1995). Lebensmittelführer 2.<br />

Stuttgart: Georg Thieme Verlag.<br />

9<br />

Biesalski, H. K., & ad., e. (2002). Vitamine, Spurenelemente<br />

und Mineralstoffe. Stuttgart: Georg Thieme Verlag.<br />

10<br />

Hahn, A., & Schuchardt, J. (2011). Minerals - Metabolism,<br />

functions, Requirement. Hamburg: B. Behr's Verlag.<br />

11<br />

https://www.mri.bund.de/fileadmin/MRI/Institute/EV/<br />

NVSII_Abschlussbericht_Teil_2.pdf, 22.03.<strong>2022</strong><br />

12<br />

Scholz, H. (1996). Mineralstoffe + Spurenelemente.<br />

Stuttgart: Georg Thieme Verlag.<br />

13<br />

Friesenwinkel, H. (2005). Mineralstoffe. München:<br />

Knaur Ratgeber Verlage.<br />

14<br />

Zimmermann, M. (2003). Mikronährstoffe in der Medizin,<br />

3. Aufl. Stuttgart: Karl F. Haug Verlag.<br />

15<br />

Holmes, N., Bates, G., Zhao, Y., Sherriff, J., & Miller, V.<br />

(2016). The Effect of Exercise Intensity on Sweat Rate and<br />

Sweat Sodium and Potassium Losses in Trained Endurance<br />

Athletes. Annal of Sports Medicine and Research, vol. 3,<br />

issue 2, S. 1-4.<br />

16<br />

Schümann, K., & Weiss, G. (2002). Eisen. In H. Biesalski,<br />

J. Köhrle, & K. Schümann, Vitamine, Spurenelemente und<br />

Mineralstoffe - Prävention und Therapie mit Mikronährstoffen<br />

(S. 137-147). Stuttgart: Georg Thieme Verlag.<br />

17<br />

Suedekum, N., & Dimeff, R. (2005). Iron and the athlete.<br />

Current Sports Medicine Reports, vol. 4, issue 4, S.<br />

199-202.<br />

18<br />

Academy of Nutrition and Dietetics, A. o., Canada, D. o.,<br />

& Medicine, A. C. (2016). Nutrition and Athletic Performance.<br />

Medicine & Science in Sports & Exercise, vol. 48,<br />

issue 3, S. 543-568.<br />

19<br />

Platen, P. (2002). Mikronährstoffe in der Sportmedizin. In<br />

K. Biesalski, J. Köhrle, & K. Schümann, Vitamine, Spurenelemente<br />

und Mineralstoffe - Prävention und Therapie mit<br />

Mikronährstoffen (S. 326-342). Stuttgart: Georg Thieme<br />

Verlag.<br />

20<br />

Koehler, K., Braun, H., Achtzehn, S., Hildebrand, U.,<br />

Predel, H.-G., Mester, J., & Schänzer, W. (2012). Iron status<br />

in elite young athletes; gender-dependent influences of<br />

diet and exercise. European Journal of Applied Physiology,<br />

vol. 112, issue 2, S. 513-523.<br />

21<br />

Deakin, V. (2006). Iron depletion in athletes. In L. Burke,<br />

& V. Deakin, Clinical sports nutrition 3 rd ed. (S. Ch. 10 1-9).<br />

Sydney; New York: McGraw-Hill.<br />

22<br />

Fuhrman, J., & Deana, M. (2010). Fueling the Vegetarian<br />

(Vegan) Athlete. Current Sports Medicine Reports, vol. 9,<br />

issue 4, S. 233-241.<br />

36 No. 1 April/May <strong>2022</strong>

Active ingredients<br />

Photo © : Capsularis/Unsplash<br />

A “new generation” of liposomes<br />

Although liposomes are on the rise, the<br />

products on the market often present<br />

problems of stability, traceability<br />

and organoleptic quality. Drawing on<br />

their expertise in microencapsulation,<br />

Capsularis has developed a unique<br />

liposomal process that places quality<br />

and naturality at the heart of the manufacturing<br />

process, in order offer to their<br />

customers premium liposomes 100 %<br />

Made in France.<br />

Capsularis offers vitamin C liposomes under<br />

the L-VITAL C ® brand. Is it just an additional<br />

offer from a company that made the vectorization<br />

of active ingredients its specialty?<br />

Not exactly: the technology used provides<br />

surprising solutions on the organoleptic level<br />

which renew the application of liposomes.<br />

Natural health supplements contain many<br />

active ingredients, such as vitamins, trace<br />

elements, antioxidants, etc. Digestion can<br />

degrade these active ingredients, or they can be poorly absorbed by<br />

the body. Their effectiveness can therefore be reduced. In order to<br />

improve the assimilation of vitamin C, Capsularis offers you its innovation,<br />

a microencapsulated vitamin C, in liposomal form: L-VITAL C ® .<br />

“When we started to develop a drinkable solution incorporating<br />

our liposomes, we were pleasantly surprised by its very pleasant<br />

taste and its remarkable stability”, reveals Stéphane Lozachmeur,<br />

founder and manager of Capsularis. “This innovation in the field of<br />

liposomes will allow us to bring innovation to our customers”. Innovation<br />

is anchored in the DNA of the company founded in 2008 and<br />

which relies in particular on a microencapsulation process developed<br />

in-house. The company, which has nearly twenty people, has<br />

its own R&D department which is equipped with a pilot lab to validates<br />

the scale-up.<br />

To develop its liposomes, the Capsularis R&D team focused on technologies<br />

for producing lipid vectors used in the pharmaceutical<br />

industry. The company invested in a production unit, which makes it<br />

possible to produce liposomes smaller than 200 nm. Another advantage<br />

of this new production equipment: the technology makes it<br />

possible to produce at low temperatures, which contributes to the<br />

preservation of active ingredients.<br />

No. 1 April/May <strong>2022</strong><br />


Active ingredients<br />

What is a liposome?<br />

The word liposome, also called “lipid body”, comes from the Greek<br />

lipos, which means fat, and soma, the body. The discovery of<br />

liposomes dates back to the 1960s, during work carried out by Alec<br />

Bangham in Cambridge 1 . Liposomes were initially developed as a<br />

model of biological membranes, through their ability to imitate cell<br />

membranes. They have long been studied as vectors of active principles<br />

2 .<br />

The liposome is a lipid vesicle which carries an active ingredient.<br />

Photo © : Capsularis/Her-bak Médias<br />

The structure of the liposome is similar to the cell membranes of<br />

our body.<br />

Photo © : Capsularis/Her-bak Médias<br />

Liposomes are made up of phospholipids, fatty substances present in<br />

our diet. They are found for example in cereals, nuts, eggs, sunflower.<br />

A phospholipid is composed of a hydrophilic head and hydrophobic<br />

tails.<br />

Thanks to its small size and this biomimicry, the liposome fuses with<br />

cell membranes. The active ingredient crosses the intestinal barrier<br />

more easily thanks to a mechanism called endocytosis. The active<br />

ingredient is released directly into the body, its bioavailability is thus<br />

improved.<br />

Thanks to their small size and to the phospholipids that make up<br />

their membrane, liposomes can be absorbed intact by certain cell<br />

types in the intestine. Therefore, vitamin C in liposomal form will<br />

partly bypass the classic absorption pathways which are saturable<br />

and will be more bioavailable than its non-liposomal counterpart. 3<br />

Studies have also shown that liposomal vitamin C is almost twice<br />

as bioavailable in the blood, compared to conventional vitamin C. 4-5<br />

The bioavailability of the active ingredient contained in the liposome<br />

is thus improved.<br />

Liposomes allow:<br />

– A protection of active ingredients from acid attacks in the stomach<br />

– An Improved bioavailability<br />

“We decided to develop our own liposomal formulations to offer on<br />

one hand a product Made in France and on the other hand because<br />

we believed that our expertise in microencapsulation would bring a<br />

differentiating element to the market.”<br />

Photo © : Capsularis/Her-bak Médias<br />

Phospholipids are naturally organized into bilayers, then into<br />

liposomes in which an active ingredient can be encapsulated.<br />

Major breakthrough: Capsularis offers liposomes in a stable liquid<br />

form. There is a plethora of liposomes in powder form on the market,<br />

but liposomes need water to live/exist. Without it, their structure<br />

becomes unstable and breaks down: liposomes become unable to<br />

hold active ingredients in their heart.<br />

38 No. 1 April/May <strong>2022</strong>

Active ingredients<br />

Essential Vitamin C<br />

Ascorbic acid, isolated in 1931 and synthesized<br />

in 1933 by two Nobel Prize winners in<br />

chemistry, is one of the vitamins described<br />

as essential for the optimal functioning of<br />

the human body. However, ascorbic acid<br />

can cause hyperacidity in the body. A more<br />

interesting choice to avoid this hyperacidity<br />

is vitamin C in the form of sodium ascorbate,<br />

which is none other than the sodium<br />

salt of L-ascorbic acid. Since the body is<br />

unable to synthesize vitamin C, we must<br />

find it in our diet.<br />

Vitamin C health benefits are numerous, and<br />

the most famous one is its antioxidant power.<br />

It is also an enzymatic cofactor essential to<br />

many biochemical reactions in the body.<br />

Proven health benefits:<br />

– Helps reduce fatigue<br />

– Strong antioxidant power to neutralize<br />

excess free radicals, essential for cell<br />

protection. It protects cells from oxidative<br />

stress and premature cell aging.<br />

– Contributes to the normal formation of<br />

collagen to ensure the normal function of<br />

the skin, teeth, gums, bones, cartilages<br />

and blood vessels.<br />

– Contributes to the proper functioning of<br />

the immune system (during and after<br />

intense physical exercise) and of the<br />

nervous system<br />

– Contributes to normal psychological<br />

functions<br />

– Contributes to normal energy metabolism<br />

and increases iron absorption.<br />

– Contributes to the regeneration of the<br />

reduced form of vitamin E<br />

L-VITAL C benefits<br />

– Liquid form: optimal efficiency/high<br />

assimilation<br />

– Absence of acidity (gastric), excellent<br />

digestive tolerance<br />

– Superior organoleptic qualities<br />

– Stability of liposomes over time<br />

– Traceability and quality of raw materials<br />

– Liposome size control<br />

– GMO-free, dye-free manufacturing<br />

– Suitable for the vegan diet<br />

– Produced in France, Brittany<br />

References<br />

1<br />

Meybeck A., Les liposomes en cosmétique, l’actualité chimique, 2008, 323-324, p.60.<br />

2<br />

He et al. Adapting liposomes for oral drug delivery. Acta Pharmaceutica Sinica B, 9(1),<br />

2019, 36-48.<br />

3<br />

He et al. Adapting liposomes for oral drug delivery. Acta Pharmaceutica Sinica B, 9(1),<br />

2019, 36-48<br />

4<br />

Hickey S, Roberts HJ, Miller NJ. Pharmacokinetics of oral vitamin C. J Nutr Environ Med.<br />

2008, 17(3):169–177.<br />

5<br />

Gopi et al. Evaluation and Clinical Comparison Studies on Liposomal and Non-Liposomal<br />

Ascorbic Acid (Vitamin C) and their Enhanced Bioavailability. Journal of Liposome<br />

Research, 2020, 1–35.<br />




All natural, tasteless, colorless and odorless<br />

Boosts health benefits and improves functionality<br />

of foods and beverages<br />

No side effects like bloating,<br />

cramping and gas production<br />

Satiety effect<br />

Enhances mineral absorption<br />

Lowers glycaemic index of foods<br />

Low calorie ingredient<br />

Kosher & Halal<br />

Low-FODMAP fiber (Monash University)<br />

GRAS Self-Affirmation<br />

ISO certified (natural ingredient)<br />

For more information, please contact<br />

Stéphane LOZACHMEUR<br />

contact@seanova.fr<br />


7 chemin de Kilourin<br />

29170 Pleuven, France<br />

www.seanova.fr<br />



IN GENEVA,<br />

HALL 4, F90<br />

TAIYO GmbH<br />

Hagener Str. 20, D-58285 Gevelsberg<br />

Tel. +49 2332 96788-0<br />

info@taiyogmbh.com · www.taiyogmbh.com<br />

No. 1 April/May <strong>2022</strong><br />


Antioxidants in baked goods<br />

Photo © : AdobeStock/fabiomax<br />

Natural solutions in baked goods. From early<br />

civilizations to modern innovation!<br />

A few years ago, charred remains of a flatbread baked<br />

14,000 years old, was found in the Jordanian desert. This<br />

fact could attest bread is the most compelling evidence of<br />

humans moving from hunter-gatherer societies to agricultural-based<br />

societies. Baking is probably one of the most<br />

ancient processes ever created by human kind. Wheat was<br />

already cultivated by the first civilizations in human history.<br />

They learned that wheat kernels could be grinded and transformed<br />

into flour, and by adding water to it and baking it,<br />

bread would be obtained.<br />

Nowadays, in modern and western societies, baked cereal pro ducts<br />

are one of the most consumed goods, and also one of the main<br />

sources of energy in human nutrition. This high and increasing<br />

demand of baked goods, is driving the manufacturers of the food<br />

industry to keep innovating and developing new formulations that can<br />

meet the quality requirements that the global population demands, in<br />

terms of safety, health and sustainability.<br />

To produce basic products such as bread, biscuits, cakes and pastry,<br />

the baking industry uses a wide range of natural raw materials. The<br />

essential ingredients for all baked products are flour, water and salt.<br />

In addition, for bread products, yeast, fats and minor ingredients can<br />

be included in the recipe.<br />

Therefore, when a new formula of a baked<br />

product is designed, the impact of new<br />

ingredients on the chemical transformations<br />

occurring during the production chain has<br />

to be determined. During preparation and<br />

baking of cereal products, many complex<br />

phenomena occur in the dough, leading to<br />

textural, physicochemical and organoleptic<br />

changes. Among the most important, we can<br />

cite volume expansion, starch gelatinisation,<br />

protein denaturation, fat melting, browning<br />

and formation of flavour compounds.<br />

Also, changing ingredients may have an<br />

impact on the main reactions occurring<br />

during the baking process, such as the<br />

Maillard reaction, caramelisation and lipid<br />

oxidation. The Maillard reaction occurs<br />

between the carbonyl groups of reducing<br />

sugars and the free amine functions of<br />

amino acids, peptides and proteins. Caramelisation<br />

depends on direct degradation<br />

of sugars. Lipid oxidation is a radical chain<br />

reaction, which can be decomposed into<br />

40 No. 1 April/May <strong>2022</strong>

Antioxidants in baked goods<br />

three phases (initiation with formation of<br />

free radicals, propagation and finally termination<br />

with formation of non-radical products).<br />

Whereas the Maillard reaction and<br />

caramelisation need high activation energy<br />

and thus mainly occur during thermal treatments,<br />

lipid oxidation requires low energy<br />

along with oxygen.<br />

Fats impart taste and texture to the product<br />

but because they susceptible to oxidation<br />

leading to the development of rancidity and<br />

off-flavour through the autooxidation or lipid<br />

oxidation reactions, additives, such as antioxidants<br />

are also added to the mixture.<br />

Antioxidants have become an indispensable<br />

group of food additives mainly because<br />

of their unique properties of enhancing<br />

the shelf life of food products without any<br />

damage to sensory or nutritional qualities.<br />

Concerns about the safety of synthetic antioxidants<br />

have given rise to a large body of<br />

research on natural sources of antioxidants.<br />

Natural antioxidants allow food processors<br />

to produce stable products with ‘‘clean’’<br />

labels of all-natural ingredients. They bring<br />

less rigorous burden-of-safety proof than<br />

that required for synthetic products. In addition<br />

to their antioxidant activity, some natural<br />

antioxidants, such as vitamins, minerals,<br />

and enzymes, are also regarded as nutrients<br />

due to their bioactivity.<br />

Tocopherols and tocotrienols, collectively<br />

known as tocols, are monophenolic and lipophilic<br />

compounds that are widely distributed in plant tissues. The<br />

main commercial source of natural tocopherols is the soybean oil.<br />

Tocotrienols, less common than tocopherols, are present in palm oil,<br />

rice bran oil, as well ascereals and legumes. Tocopherols and tocotrienols<br />

are classified into alpha, beta, gamma, delta, depending on<br />

their chemical structures. These eight molecules are part of the group<br />

known as vitamin E.<br />

Tocopherols and tocotrienols are primary antioxidants, which act by<br />

terminating the free-radical chain reaction by donating hydrogen or<br />

electrons to free radicals and converting them to more stable products.<br />

Secondary antioxidants, such as ascorbic acid, citric acid, lecithin<br />

or flavonoids can be also added to the products. Secondary antioxidants<br />

can be broadly classified as oxygen scavengers and chelators.<br />

They have a synergic effect, together with tocopherols, as they<br />

act as hydrogen donors to the tocopheryl radical, thereby regenerating<br />

the primary antioxidant. Hence tocopherols can be used at<br />

lower levels if a synergist is incorporated simultaneously in the food<br />

product.<br />

In order to protect the baked goods from oxidation, antioxidants can<br />

be applied either to the final product, or directly to the oil previous<br />

to the mixing of ingredients. To measure the efficacy of tocopherolbased<br />

antioxidants, accelerated oxidation tests have been performed.<br />

In the first experiment, the Rancimat test was used. It is a simple,<br />

quick an efficient way to screen the effectiveness of antioxidants<br />

used in fats and oils. The method is an accelerated oxidation test in<br />

which the oil or fat to be tested is run at elevated temperatures whilst<br />

exposing the sample to air, accelerating the oxidation process of the<br />

oil. Soybean oil, one of the mayor oils in the baking industry, was<br />

mixed with different tocopherol-based natural antioxidants.<br />

Tocobiol ® is a natural antioxidant made from the distillation of a single<br />

raw ingredient, whole non-GMO soybean oil. It naturally contains<br />

mixed tocopherols, plant sterols, squalene and monoglycerides<br />

which provide its unique antioxidant and dispersibility properties.

Antioxidants in baked goods<br />

It can be concluded that the use of tocopherols and its blends with<br />

other secondary natural antioxidants is a very effective method for<br />

protecting the fats and oils present in baking goods towards autoxidation<br />

and avoid rancidity in the final product.<br />

As it can be seen in Table 1, the addition of synergic antioxidants,<br />

such as the flavonoids present in green tea extract, ascorbyl palmitate,<br />

produced a significant increase in the stability of the oil, even<br />

higher than that produces by a tocopherol rich extract.<br />

A second experiment was performed on pretzel dough, using the<br />

RapidOxy method. The principle of this technique lies in the artificial<br />

acceleration of the oxidation process by increasing the temperature<br />

and oxygen pressure, which is in contact with the sample in a<br />

sealed chamber. This method allows us to measure the oxidation of<br />

solid products, such as this case.<br />

References<br />

1. Amaia Arranz-Otaegui, Lara Gonzalez Carretero, Monica N. Ramsey, Dorian Q. Fuller, and<br />

Tobias Richter. “Archaeobotanical evidence reveals the origins of bread 14,400 years ago<br />

in northeastern Jordan” PNAS<br />

2. Walker, C.E., and Eustace, W.D. “Wheat Processing” Encyclopedia of Food Grains, vol. 3,<br />

Elsevier Ltd., 2016, pp. 299–304<br />

3. Murielle Maire, Barbara Rega, Marie-Elisabeth Cuvelier, Paola Soto, Pierre Giampaoli.<br />

"Lipid oxidation in baked products: Impact of formula and process on the generation of<br />

volatile compounds”. Food Chemistry 141 (2013) 3510–3518<br />

4. B. Nanditha, P. Prabhasankar. “Antioxidants in Bakery Products: A Review”. Critical<br />

Reviews in Food Science and Nutrition, 49:1–27 (2009)<br />

5. S. S. Sahi, Campden BRI. “Applications of natural ingredients in baked goods” Natural<br />

Food Additives, Ingredients and Flavourings, 318-332<br />

6. A. Sayago, M.I. Marín, R. Aparicio, y M.T. Morales. “Vitamina E y aceites vegetales”<br />

GRASAS Y ACEITES, 58 (1), ENERO-MARZO, 74-86, 2007<br />

7. Bailey’s Industrial Oils and Fat Products: Sixth Edition, Six Volume Set. Chapter 12.<br />

Edited by Fereidon Shahidi (2005). John Wiley & Son, Inc<br />

For more information, please contact<br />

BTSA<br />

Tecnoalcalá Calle Arroba 4. 28805<br />

Alcalá de Henares, Madrid, Spain<br />

info@btsa.com<br />

www.btsa.com<br />

42 No. 1 April/May <strong>2022</strong>

Oil and fats<br />

Photo © : AdobeStock/anaumenko<br />

Valuable fats<br />

Virgin coconut oil and MCT oil: effective<br />

energy suppliers<br />

The coconut is a real all-rounder:<br />

the nectar of its flowers yields valuable<br />

coconut sugar, whilst refreshing<br />

coconut water is obtained from green<br />

and unripe coconuts. Coconut milk is<br />

a prized vegan and lactose-free milk<br />

substitute and the fatty flesh of the<br />

coconut is used to make many pro ducts<br />

besides milk, such as high-quality<br />

virgin coconut oil and special MCT oil.<br />

These oils are particularly valuable for<br />

their medium-chain fatty acids, since<br />

this makes them important suppliers of<br />

energy. Import Promotion Desk (IPD)<br />

supports Sri Lankan producers of virgin<br />

coconut oil and MCT oil and accompanies<br />

them to the European market.<br />

Special fatty acids<br />

Once the coconut is cracked, the inside<br />

comes to light. If the coconut is ripe this<br />

consists mainly of fruit flesh, with very little coconut water left.<br />

The white flesh tastes sweet and slightly nutty. It contains a mix of<br />

minerals, such as potassium, sodium, iron and magnesium, plenty<br />

of fibre and few carbohydrates. Also, the wide variety of vitamins in<br />

the flesh, including vitamin C, B1, B2, B3, B4, B5, B6 and E should<br />

be highlighted.<br />

In addition, coconut flesh is high in fat and calories: it has a fat<br />

content of 36.5 grams per 100 grams. It contains mainly saturated<br />

fatty acids, that means medium-chain triglycerides (MCT). These fatty<br />

acids of medium-chain length, i. e. of six to twelve carbon atoms, can<br />

be split up and digested more easily than the usual dietary fats with<br />

long-chain fatty acids. Therefore, the body can convert them into<br />

energy more quickly, making them very effective energy suppliers.<br />

Example: lauric acid<br />

One of these medium-chain fatty acids is lauric acid. It was named<br />

after “Laurus nobilis“, the Latin name for laurel, and the oil of the<br />

laurel consists largely of lauric acid. Cold-pressed coconut oil is also<br />

known for its high level of lauric acid, which is said to have an antiviral<br />

and antibacterial effect, protect against infections and be good<br />

No. 1 April/May <strong>2022</strong><br />


Oil and fats<br />

for intestinal health. As a skincare product,<br />

coconut oil is thought to provide protection<br />

against ticks due to the scent of lauric acid.<br />

Coconut oil is also used to treat muscle pain.<br />

Cold pressed: virgin coconut oil<br />

Photo © : Asian Agro<br />

To produce cold-pressed coconut oil, known<br />

as “virgin coconut oil”, the flesh is separated<br />

from the nut and crushed. Before pressing,<br />

the fresh, watery flesh must be dried. The<br />

dried coconut, called “copra”, is then coldpressed<br />

in an oil mill. Virgin coconut oil is<br />

neither bleached, hardened nor deodorised.<br />

The production process has a major influence<br />

on the quality and possible uses of<br />

coconut oil. The IPD companies from Sri<br />

Lanka only offer virgin coconut oil. Through<br />

modern equipment, analytical procedures<br />

and quality management systems they have<br />

specialised in gentle pressing.<br />

Photo © : Nisudha<br />

Photo © : Nisudha<br />

Coconut oil changes its aggregate state<br />

quickly depending on the temperature: at<br />

temperatures below 25 degrees, coconut<br />

oil is solid and white; at temperatures above<br />

that, it becomes clear and liquid. Coconut fat<br />

and oil are therefore not different products,<br />

but are instead coconut oil in solid or liquid<br />

form depending on the ambient temperature.<br />

Virgin coconut oil has the typical nutty and<br />

exotic aroma of the coconut. Due to its high<br />

content of saturated fatty acids, it is also<br />

heat-stable. It is therefore well suited for<br />

cooking and baking, as well as frying and<br />

deep-frying. Another field of application is<br />

cosmetics: coconut oil is often used in skin<br />

care products.<br />

The coconut island: Sri Lanka<br />

Photo © : Nisudha<br />

Sri Lanka is one of the main areas where<br />

coconut palms are cultivated and the<br />

fourth largest global exporter of coconuts<br />

and coconut products. The main focus of<br />

production is in what is known as the coconut<br />

triangle between the towns of Kurunegala,<br />

Chilaw and Puthtalam in the east of the<br />

island. But outside this region too the island<br />

state has a great many coconut plantations,<br />

mainly run by small, family businesses.<br />

44 No. 1 April/May <strong>2022</strong>

Oil and fats<br />

The palms grow to between 20 and 25 metres<br />

high, and the coconuts form in groups in the<br />

crown. Palm climbers regularly ascend the<br />

palms to select and harvest the ripe fruits.<br />

Each palm produces around 70 coconuts<br />

per year. Even though they grow constantly,<br />

the main coconut harvest period on Sri<br />

Lanka is between April and September.<br />

In 2021, the Sri Lankan government decided<br />

to convert its entire agricultural sector to<br />

organic production. Many small farmers<br />

pay attention to sustainable cultivation on<br />

their coconut plantations and have always<br />

refrained from using pesticides due to their<br />

traditional cultivation techniques. The Sinhalese<br />

producers in the IPD programme mostly<br />

work with peasant farmers from the region<br />

who grow organically. Their coconut products<br />

carry the EU organic label and often<br />

also other organic certifications.<br />

Demand for coconuts<br />

IPD supports a number of enterprises from<br />

Sri Lanka in marketing the products they<br />

make from coconuts, particularly the flesh.<br />

Among them is, for example, the company<br />

Nisudha Food Products, which has been<br />

producing a wide range of coconut products<br />

for over 20 years. Particularly noteworthy is<br />

the coconut oil from certified organic coconuts<br />

that Nisudha produces and exports<br />

successfully. This is because the demand for<br />

high-quality virgin coconut oil is particularly<br />

high in Europe.<br />

Extracted: MCT oil<br />

In addition to cold-pressed oil, there is<br />

another speciality from the coconut: MCT oil.<br />

This is produced by extracting the mediumchain<br />

fatty acids from coconut oil. Pure MCT<br />

oil does not occur in nature and coconut fat<br />

contains a mixture of fatty acids. The MCT<br />

fats are therefore obtained through hydrolysis.<br />

capric acids, with eight and ten carbon atoms, are said to be the two<br />

most valuable fatty acids, as they are considered to provide energy<br />

the fastest.<br />

The company Manchiee de Coco joined the IPD programme in 2019<br />

and produces not only virgin coconut oil, but also other coconut products,<br />

including the coconut-based MCT oil. The raw material for this<br />

is cold-pressed coconut oil. During production, the company ensures<br />

a high proportion of the valuable caprylic and capric acids from<br />

natural coconut oil. They are contained in the MCT oil from Manchiee<br />

de Coco in a ratio of 60:40.<br />

MCT oil is clear and watery, as well as odourless and tasteless. It<br />

mixes very well with other liquids and is suitable as an oil in sauces,<br />

salad dressings, shakes and smoothies.<br />

Speciality Bulletproof Coffee<br />

MCT oil is also the central ingredient of the new cult drink Bulletproof<br />

Coffee. Combining it with butter and coffee results in a high-energy<br />

and caffeine-rich drink. It is said to increase attentiveness as well as<br />

performance and concentration.<br />

IPD partner country Sri Lanka<br />

IPD has been supporting small and medium-sized enterprises from<br />

Sri Lanka since 2018, preparing them for the European market and<br />

introducing them to European traders at trade exhibitions in Europe.<br />

Besides the textile industry, the agricultural sector plays a leading role<br />

in Sri Lanka’s export economy. Sri Lanka is the world’s third largest<br />

tea exporter and is particularly well known for its Ceylon tea. Trading<br />

with spices, particularly cinnamon and pepper, is also a long tradition.<br />

Another growing export factor is the coconut and its products.<br />

IPD connects European importers with the carefully selected<br />

producers, opening up new buying sources for them and supporting<br />

them in the procurement process. IPD is funded by the German<br />

Federal Ministry for Economic Cooperation and Development (BMZ).<br />

For more information, please visit<br />

www.importpromotiondesk.de<br />

Caproic, caprylic, capric and lauric acids<br />

are referred to as medium-chain fatty acids.<br />

Coconut oil has a high proportion of lauric<br />

acid – around 50 percent. There is only a<br />

small amount of caproic acid, which has an<br />

unappealing taste and odour. Caprylic and<br />

No. 1 April/May <strong>2022</strong><br />


Vitafoods Europe<br />

Photo © : Vitafoods Europe<br />

Vitafoods Europe returns in May <strong>2022</strong><br />

Last October, 22,000 nutraceutical professionals came<br />

together virtually and in person to network, collaborate,<br />

and share knowledge from across the industry at Vitafoods<br />

Europe 2021. Now, Vitafoods Europe is back once again – at<br />

its usual May timeslot – combining an online platform and<br />

the in-person event in Geneva, to re-connect and inspire the<br />

nutraceutical community in an ever-changing, and increasingly<br />

health-conscious, post-COVID world.<br />

By bringing together popular in-person attractions with a lively virtual<br />

programme, Vitafoods Europe is cementing its position as the leading<br />

global event to network, forge long-term collaborations, share ideas,<br />

source innovative ingredients and new suppliers, discover new<br />

product development solutions, and hear from technical experts and<br />

industry thought-leaders.<br />

This year, visitors will be able to access the Vitafoods Europe online<br />

platform a week before the live event (2-13 May) to immerse themselves<br />

in exclusive insight-led content and use the data-driven matchmaking<br />

tool to conduct virtual meetings. Plus, the online platform and<br />

SMART technology enables them to plan their visit to Geneva and set<br />

up in-person meetings in advance to ultimately enhance their experience<br />

and maximise their time at the live event (10-12 May).<br />

Vitafoods Europe <strong>2022</strong> highlights<br />

The comprehensive event agenda explores<br />

key market trends, plus regulatory complexities,<br />

packaging and labelling challenges,<br />

and more – including an enhanced focus<br />

on pressing industry issues, such as mental<br />

wellbeing, women in nutraceuticals and<br />

sustainability. Highlights of this year’s event,<br />

across online and in person, include:<br />

Extensive industry expert insights<br />

With online content and in person presentations<br />

taking place across 4 theatres –<br />

including the Main Stage powered by<br />

Vitafoods Insights, Life Stages, New Ingredients,<br />

and Probiotics theatres – visitors can<br />

explore over 90 hours of content across the<br />

whole event. Expect talks on everything from<br />

the regulatory landscape for probiotic ingredients,<br />

to innovative prenatal supplement<br />

ingredients for child mental health.<br />

46 No. 1 April/May <strong>2022</strong>

Vitafoods Europe<br />

Tailored networking opportunities<br />

This year’s SMART event format allows for<br />

global connectivity across both the in-person<br />

and online platforms. Visitors can find<br />

and connect with potential partners and<br />

suppliers before and during the show using<br />

Informa’s intelligent data-driven matchmaking<br />

service. Facilitating efficient and<br />

effective networking, this connects visitors<br />

and exhibitors with shared goals, the right<br />

backgrounds and in-demand expertise.<br />

Discover the latest innovations<br />

Visitors looking for inspiration for their next<br />

product can tour the New Product and<br />

Ingredient Zones to discover the very latest<br />

ingredient technologies, formulations and<br />

products, as well as exploring new research.<br />

Alternatively, the virtual Innovation Tour<br />

is available in video and audio format, to<br />

complement the live show experience.<br />

Deep dive into trending ingredients<br />

with themed Resource Centres<br />

For those interested in Omega-3 fatty acids<br />

or probiotics and gut health, the tailor-made<br />

Resource Centres offer a deeper dive into<br />

these trending and expanding market areas<br />

via bespoke and exclusive expert content.<br />

Sustainability success stories<br />

With sustainability moving up the priority<br />

list for many brands, Sustainability Corner<br />

enables visitors to explore some of the challenges<br />

and the success stories, with expertled<br />

sessions on how the industry can become<br />

more sustainable.<br />

Photo © : Vitafoods Europe<br />

Following the impact of the pandemic on<br />

consumers globally, as well as the fact that<br />

many of them have busy and stressful daily<br />

lives, mental wellbeing is a key focus for<br />

Vitafoods Europe <strong>2022</strong>. This year, Informa is<br />

also hosting a new Vitafoods Europe Summit<br />

on the topic, offering an in-depth exploration<br />

of the important role of nutrition in mental<br />

wellbeing. Running the day before the exhibition,<br />

9 May, at the Fairmont Grand Hotel in Geneva, the Summit will<br />

offer insights into the latest ingredient science and its practical application<br />

in mental health nutrition solutions.<br />

As the pace of innovation continues to pick up, and with consumer<br />

interest in nutrition and health at an all-time high, there’s never been<br />

a better time to take an active role in the nutraceutical community.<br />

Vitafoods Europe <strong>2022</strong>, which will continue to run in accordance<br />

with the latest Informa AllSecure standards and local Swiss guidance,<br />

is once again set to connect the community, facilitate learning<br />

and discovery, and provide an opportunity to solve the biggest global<br />

health issues, together.<br />

For more information, please visit<br />

https://www.vitafoods.eu.com<br />

Delve into mental wellbeing<br />

No. 1 April/May <strong>2022</strong><br />


Vitafoods Europe – Preview<br />

GELITA presents cutting-edge solutions for supplements<br />

GELITA, the leading manufacturer of gelatin and collagen peptides,<br />

will be back at Vitafoods in Geneva presenting its latest solutions.<br />

SOLUFORM and VERISOL ® HST are the new smart solutions to<br />

realize fortified gummies for a demanding and growing market.<br />

GELITA ® EC is enabling enteric soft capsules safeguarding sensitive<br />

ingredients through the aggressive gastric environment. And GELITA<br />

Health provides turnkey products with scientifically proven BCP ®<br />

ready to market for the customer in all sales channels. Join our educational<br />

sessions and accept the GELITA <strong>Wellness</strong> Challenge on site.<br />

Healthy but tasty, please<br />

GELITA developed three brand new products for fortified gummy solutions<br />

to deliver all the health benefits that consumers are requesting<br />

while ensuring great taste and texture. Beside all this it secures hassle<br />

free production.<br />

SOLUFORM PE – the protein booster for your confectionery!<br />

SOLUFORM PE is optimized for the production of fruit gummies<br />

with high protein content. By combining the performance of gelatin<br />

and the protein source in one functional ingredient, the manufacturing<br />

of protein enriched gummies gets as easy as possible.<br />

SOLUFORM SR – next generation gelatin for<br />

sugar reduced confectionery!<br />

SOLUFORM SR allows to reduce the sugar concentration of confectionery<br />

without affecting the texture. Thereby a sugar content of a<br />

fruit gummy can be cut down from 70 % to 40 %. Furthermore this<br />

leads to a reduced carbohydrate content. Even no-sugar concepts<br />

are possible using SOLUFORM SR.<br />

VERISOL ® HST for next generation beauty gummies!<br />

VERISOL ® HST is optimized for the production of collagen enriched<br />

fruit gummies. It replaces both, gelatin and collagen peptides and<br />

enables a concentration of 15 % BCP ® in fruit gummies without<br />

affecting the taste and texture of the final product. In this way<br />

VERISOL ® HST is the perfect solution to cater fortified gummies of the<br />

beauty from within segment with the required high dosage of BCP ® .<br />

Safeguard sensitive active ingredients to the intestine<br />

Consumers have been ingesting nutrients in soft capsules for decades<br />

due to their ease of swallowing and convenience. While for some<br />

fills it is important to be released as fast as possible, like analgesics,<br />

for other sensitive substances it is crucial they are transported safely<br />

through the aggressive stomach environment to be released only in<br />

the small intestine. In this way you also can avoid the nagging fishy<br />

burps caused by an early release of omega 3 in the stomach.<br />

Instead of applying an acid-insoluble opaque coating to the capsule<br />

in a second time and cost-consuming production step, GELITA ® EC<br />

allows production of crystal clear enteric soft caps in one single step<br />

using existing equipment.<br />

Innovations for a life in motion<br />

From concept to shelf, our goal is to provide customers with turn-key<br />

BCP ® solutions to create innovative products in their selected application<br />

area from tailor-made recipes to individual packaging. Take<br />

advantage of the GELITA Health expertise, resources, and network<br />

to speed-up your go-to-market! Use your own brand or license one<br />

of the strong international GELITA HEALTH brands – it is up to you.<br />

GELITA<br />

www.GELITA.com<br />

www.GELITA-HEALTH.com<br />

GELITA at Vitafoods, booth I110<br />

Taiyo presents innovative concepts<br />

for natural-based products<br />

Taiyo launches reformulated protein shake concepts in three flavours,<br />

and showcases ingredients that support a long-term healthy lifestyle.<br />

At Vitafoods Europe, functional ingredient expert Taiyo will present<br />

brand new concepts which address current consumer trends, such<br />

as healthy ageing, sports nutrition and clean label products. The<br />

company will showcase new additions to its Sunfiber ® portfolio – an<br />

all-natural, 100 % soluble dietary fiber – as well as its new Sunfiber ®<br />

Water Concept, an optimum hydration offering with health-boosting<br />

properties. It will also present Sunphenon EC, known for its high polyphenol<br />

and catechin content with proven antioxidant effects. Other<br />

highlights at the Taiyo stand include functional ingredients such as<br />

concentrated Moringa seed extract and new Vegemeat concepts.<br />

With Sunphenon EC, Taiyo offers a new variant in addition to existing<br />

green tea extracts. This product in the Sunphenon range is rich<br />

in epicatechin, which is found predominantly in cocoa and green<br />

tea, and has a proven positive effect on the cardiovascular system.<br />

Furthermore, a decrease in morbidity and mortality from cardiovascular<br />

diseases is associated with the consumption of flavanols. 1<br />

Therefore it is perfect for elderly people or other consumers who have<br />

problems with muscle health, such as muscle atrophy. The product<br />

has been specially developed for use in instant tea sticks, instant<br />

beverages or supplements.<br />

Vitafoods visitors will also be able to learn more about Taiyo’s Chia<br />

Protein XiaPure ® . Chia seeds are a real health-booster: They contain<br />

essential amino acids necessary for good health and they are an<br />

excellent alternative source of protein for sports nutrition. With<br />

XiaPure ® , a finely milled, high-quality vegan protein powder from<br />

Chile, Taiyo provides a new formulation for their Vegan Protein<br />

Shake. The chia protein makes the mouthfeel much smoother and<br />

Taiyo’s ingredients: Sunfiber ® , Raw Coffee Powder and SunActive ®<br />

Zinc deliver added nutritional value. The concept can be used for<br />

ready-to-drink shakes or protein-enriched ice cream, and is available<br />

in three different flavours.<br />

48 No. 1 April/May <strong>2022</strong>

Vitafoods Europe – Preview<br />

The third innovation Taiyo is presenting is the Sunfiber ® Water<br />

Concept. With this novelty, Taiyo addresses different target groups,<br />

including the ageing population. This generation often does not<br />

consume enough water or vital nutrients. This unique concept,<br />

however, allows for the production of isotonic drinks that contain less<br />

sugar and additional dietary fibre, allowing for much higher bioavailability<br />

of minerals. It is also possible to customize such beverages by<br />

adding more active ingredients such as Q10 or curcumin, depending<br />

on the target group. For example, children or athletes could benefit<br />

from the Sunfiber ® Water Concept, as these groups are dependent<br />

on a targeted nutrient intake.<br />

Other highlights at the Taiyo stand include the various Sunfiber ®<br />

Blends with different added health benefits, as well as Moringa,<br />

a standardised leaf powder with 1 % glucomoringin that has antiinflammatory<br />

properties, and new concepts surrounding the peabased<br />

meat alternative Vegemeat for various consumer groups.Dr<br />

Stefan Siebrecht, Managing Director at Taiyo’s German subsidiary,<br />

says: “The Corona crisis has had a major impact on consumers<br />

interest in healthy eating. More and more people are questioning the<br />

ingredients in a product, and increasingly want natural and plantbased<br />

alternatives. Taiyo presents solutions and products with which<br />

the industry can meet these demands.”<br />

1<br />

Heiss, C., C. L. Keen and M. Kelm (2010). "Flavanols and cardiovascular<br />

disease prevention." Eur Heart J 31(21): 2583-2592.<br />

TAIYO<br />

www.taiyogmbh.com<br />

Taiyo GmbH at Vitafoods, booth F90<br />

Rousselot ® set to inspire at Vitafoods <strong>2022</strong> with<br />

new consumer study into its unique collagen matrix<br />

for joint care<br />

Rousselot ® , Darling Ingredients’ health brand and the global leader<br />

of collagen-based solutions 1 , invites visitors to booth I114 at Vitafoods<br />

<strong>2022</strong> to discover its latest collagen and gelatin ingredient innovations.<br />

At this year’s event, Rousselot’s exhibition will reintroduce its all-inone<br />

collagen matrix designed to provide joint care solutions for a wide<br />

range of consumer demographics. In addition, the company will spotlight<br />

the benefits of porcine collagen ingredients and its SiMoGel<br />

gelatin solution for innovative nutraceutical gummies.<br />

Visitors to Rousselot’s booth can also make use of the Live Chat<br />

Corner, allowing them to connect and discuss with formulation<br />

experts and also explore tailored technical solutions for their specific<br />

formulation challenges.<br />

Presenting a new perspective on senior joint care<br />

In less than 30 years, the number of people aged 60 years and over is<br />

expected to double, reaching a total of 2.1 billion 2 . In parallel to these<br />

demographic changes, the market value of dietary supplements<br />

aimed at supporting mobility is forecast to grow by 4.7 % CAGR by<br />

2026 3 . The stage is set for a new generation of nutritional solutions,<br />

formulated to support bone and joint health and help an aging global<br />

population keep fit into later life. On Tuesday 10 May at 2:30pm at<br />

the Life Stages Theatre, Dr. Sara De Pelsmaeker, Global Business<br />

Development Health & Nutrition at Rousselot will unveil the findings<br />

of a wide-ranging new study to help brands address these shifting<br />

consumer trends. Through her speech, entitled ‘Joint care innovation<br />

with an all-in-one collagen matrix, fueled by new consumer-based<br />

science’, attendees will discover the impact of Rousselot’s collagen<br />

matrix on the real-world joint care of more than two-hundred people,<br />

all varying in age, gender, and activity level.<br />

Broadening access to science-backed collagen solutions<br />

The company’s flagship collagen brand, Peptan ® is a fully bioavailable<br />

collagen peptide ingredient which delivers a world of science-backed<br />

health benefits, from joint support and bone health, to enhanced skin<br />

and hair beauty. At this year’s Vitafoods event, Rousselot will highlight<br />

the specific advantages of Peptan P, an accessible premium-quality<br />

collagen solution of porcine origin that offers a fast route to market.<br />

Event attendees can experience the functional and sensory properties<br />

of Peptan P on-stand, through specialized samples, including<br />

an oat-based breakfast solution tailored for the nutritional needs of<br />

seniors.<br />

Innovative gelatin solutions for center-filled functional gummies<br />

With an attractive appearance, taste and texture that makes them<br />

easy to swallow, the appeal of nutritional gummies is easy to understand.<br />

Manufacturing this type of delivery format however, can be<br />

a difficult task, as traditional starch molding techniques present a<br />

risk of active pharmaceutical ingredient (API) cross-contamination.<br />

Rousselot’s innovative SiMoGel gelatin solution means manufacturers<br />

can produce functional, liquid-center filled gummies using an<br />

inherently hygienic, starch-free molding technique. These innovative<br />

‘gummy caps’ allow for higher and more accurate API dosing, with<br />

virtually no risk of interaction with the gelatin excipient. SiMoGel’s<br />

unique potential can be discovered in person at Rousselot’s booth,<br />

where visitors can sample liquid-center gummies with Ibuprofen,<br />

along with other inspiring application prototypes for the all-in-one<br />

collagen matrix.<br />

1<br />

Global Gelatin Market Insights Forecast to 2026, Calibre Research,<br />

2020.<br />

2<br />

The World Health Organisation, Aging and Health, October 2021,<br />

https://www.who.int/news-room/fact-sheets/detail/ageing-andhealth#:~:text=By%202050%2C%20the%20world's%20population,2050%20to%20reach%20426%20million<br />

3<br />

Euromonitor<br />

Rousselot ®<br />

www.rousselot.com<br />

Rousselot ® at Vitafoods, booth I114<br />

No. 1 April/May <strong>2022</strong><br />


Vitafoods Europe – Preview<br />

Keep fit and active into later life<br />

Euromed presents its extended range of Mediterranean fruit and<br />

vegetable extracts for healthy ageing and wellbeing<br />

At this year's Vitafoods Europe, Euromed will showcase its well-known<br />

standardised herbal extracts, the Earth Harmony Organic Extracts ® ,<br />

as well as a growing portfolio of natural ingredients inspired by the<br />

health-promoting properties of the Mediterranean diet. In addition to<br />

lemon, olive, fig, artichoke and pomegranate fruit extracts, the iconic<br />

botanical manufacturer will also showcase its recently launched<br />

sports nutrition ingredient, the spinach-derived Spisar ® . Visitors to<br />

the Euromed booth will learn more about the latest research findings,<br />

health benefits and various applications of these high-quality<br />

extracts, suitable for inclusion in pharmaceutical, nutraceutical,<br />

cosmeceutical, food and beverage finished products.<br />

An ever-increasing older population wishing to stay well into later life<br />

is driving demand for products that support an active and healthy lifestyle.<br />

Euromed’s Wellemon ® , Pomanox ® , Mediteanox ® , ABAlife ® and<br />

Cynamed ® extracts perfectly tap into this trend, as they contain valuable<br />

nutrients that play a key role in the Mediterranean diet and have<br />

been proven to support cardiovascular, metabolic, antioxidant, digestive,<br />

immune and skeletal muscle functions, all of which are critical<br />

for healthy ageing.<br />

Inspired by this nutritional model, Euromed will be highlighting its<br />

portfolio of extracts and presenting its new Spisar ® spinach extract.<br />

Obtained from the nutrient-rich leaves of spinach cultivated in<br />

southern Spain, it is gently processed with the Pure-Hydro Process ® ,<br />

an eco-friendly, proprietary extraction technology that uses only purified<br />

water as a solvent. Spinach leaves have a naturally high content<br />

of phytoecdysteroids, plant secondary metabolites with a wide range<br />

of potential physiological and health benefits, such as improved<br />

physi cal performance and skeletal muscle fitness. Spisar ® is standardized<br />

for 20-hydroxyecdysone (20E) – the major naturally-occurring<br />

ecdysteroid in plants.<br />

Researchers from the Sports Physiology Department at the Universidad<br />

Católica San Antonio de Murcia (UCAM) 1 , in Spain, investigated<br />

the efficacy of daily consumption of Spisar ® spinach extract<br />

compared to placebo in combination with moderate-intensity skeletal<br />

muscle strength training.<br />

The results of the 12-week randomised, double-blind, placebocontrolled<br />

trial revealed that supplementation with Spisar ® significantly<br />

improved muscle strength and muscle quality in subjects aged<br />

over 50 compared to a placebo. The published study also highlighted<br />

improvements in muscle mass and quality, as well as quality of life.<br />

The authors concluded that Spisar ® in conjunction with physi cal exercise<br />

may exert overall “all-body strengthening” adaptogenic activity,<br />

and may be beneficial for improving and maintaining muscle health<br />

and fitness, both of which are crucial for healthy ageing.<br />

Andrea Zangara, Head of Scientific Communications & Marketing,<br />

says: “It’s clear that the older generation wants to delay the decline in<br />

physical capacity that comes with age for as long as possible. Preventive<br />

and active measures will help promote mobility and strength.<br />

Both the newly launched and existing Mediterranean fruit and vegetable<br />

extracts will help our customers meet this market demand.”<br />

1<br />

Pérez-Piñero, S.et.al (2021): A 12-Week Randomized Double-Blind<br />

Placebo-Controlled Clinical Trial,Evaluating the Effect of Supplementation<br />

with a Spinach Extract on Skeletal Muscle Fitness in Adults<br />

Older Than 50 Years of Age. Nutrients 2021, 13, 4373.<br />

Euromed S.A.<br />

www.euromedgroup.com<br />

Euromed at Vitafoods, booth C94<br />

Impressum<br />

ISSN 2364-8104<br />

<strong>Wellness</strong> <strong>Foods</strong> & <strong>Supplements</strong> | No. 1 /<strong>2022</strong><br />

Publishing Company<br />

Dr Harnisch Publications<br />

Dr Claus-Jörg Harnisch, Benno Keller<br />

Eschenstr. 25 | D-90441 Nuremberg | Germany<br />

Phone: +49 (0)911 2018-0<br />

Fax: +49 (0)911 2018-100<br />

wfs@harnisch.com | www.harnisch.com<br />

Editor-in-Chief Silke Watkins<br />

Publisher Benno Keller<br />

Editorial team Sebastian Martinek |<br />

Ian Healey<br />

Media Representatives<br />

France<br />

Edouard Costemend<br />

edouard.costemend@free.fr<br />

Northern Europe | Germany | Austria | Switzerland<br />

Benno Keller<br />

keller@harnisch.com<br />

Media Service Ingredients<br />

Carola Weise<br />

weise.harnisch@web.de<br />

North America<br />

Bill Kaprelian<br />

kaprep@harnisch.com<br />

Subscription information Qualified readers, executives<br />

in the food industry, are put on the mailing list free of<br />

charge. Regular delivery by subscription only.<br />

Number of issues 3 times per year<br />

Annual subscription (3 issues)<br />

surface mail for customers from abroad<br />

EUR 54 (EUR 39 + 15 EUR p+h)<br />

US $ 70 (US $ 51 + US $ 19 p+h)<br />

airmail<br />

EUR 66 (EUR 39 + EUR 27 p+h)<br />

US $ 86 (US $ 51 + US $ 35 p+h)<br />

printed by Schleunungdruck GmbH | Eltertstr. 27<br />

D-97828 Marktheidenfeld | Germany<br />

www.schleunungdruck.de<br />

Copyright © <strong>2022</strong><br />

Dr Harnisch Verlags GmbH | Nuremberg | Germany<br />

50 No. 1 April/May <strong>2022</strong>

Technology & Marketing<br />

International Magazine June 2020 ISSN 2628-5851<br />

International Magazine October 2019 ISSN 2628-5851<br />

International Magazine April 2020 ISSN 2628-5851<br />

2/20<br />

Technology & Marketing<br />

2/19<br />

xxx<br />

1/20<br />

Ingredients: Hydrocolloids in Pet Food, Acacia Gum's Versatility, Antioxidants<br />

Processing: Optical Sorting, Gentle Cooling, Removing Risks in Food Safety<br />

Packaging: Pouches and Printing, Sustainability, Choosing the Right Bags<br />

Marketing: Ask the Vet, Company News, Updates From the Fairs<br />

Ingredients Blueberries, Fiber, Seafood, Microencapsulation<br />

Processing Extrusion, Pumping and Dosing, Pellet Production<br />

Packaging Flexible Wet Packaging and Sleeving, Pouches for Treats<br />

Marketing<br />

Showcase India, Interzoo 2020 Preview<br />

Ingredients Indispensable Fatty Acids, Dietary Fiber for Pets, Yeast<br />

Processing HPP Technology, Extruding Fish Feed, Encapsulation<br />

Packaging Canning, Recyclable Bags, Cartons<br />

Marketing The Vet's Corner, News from Fairs and Firms<br />

FREE trial issue at food@harnisch.com<br />

The magazine PetFood PRO has grown out of a conviction and wish to<br />

underline the high level of quality and care in the manufacture of pet food,<br />

through the choice of ingredients, choice of technology and choice of<br />

packaging materials. We will endeavour to present this in an informative way,<br />

through a reader-friendly style and with a marketing perspective.<br />


Come and see for yourself:<br />

www.harnisch.com<br />

Perfectly<br />

positioned.<br />

The international specialist magazines from Dr. Harnisch Publications<br />

You can now explore our newly designed<br />

website, with a clear focus on responsive design<br />

and easily usable applications. Alongside the<br />

free-to-use digital magazine editions, you will<br />

fi nd bonus news coverage, events, subscription<br />

and general information on all our magazines.<br />

Take a look at www.harnisch.com for all relevant<br />

content.<br />

Our publications include:<br />

- Technology & Marketing -

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!