Wellness Foods + Supplements 1/2022

No. 1, April/May 2022 

www.harnisch.com | ISSN 2364-8104 

Functional ingredients Gut health 

Dietary fibres Micronutrients 

Marine ingredients Skin health 

Sports nutrition Oils and fats

Let Your Inspiration Flow 

World’s Leading Trade Fair for the 

Beverage and Liquid Food Industry 

September 12–16, 2022 

drinktec.com

Editorial 

SILKE WATKINS, Editor-in-Chief 

Overall well-being – a noble goal 

Vitafoods Europe is opening its doors in 

May as usual again this year. A look at the 

trade fair’s main focus areas shows that this 

edition is in tune with the times. 

Mental health is a topic that is gaining 

consider ably more attention going forward. 

Countless people have been under enormous 

stress and strain over the last two 

years. For many, this was compounded by 

sleep disturbances. Families in particular 

and especially children suffered. The mental 

stress of children and adolescents in the 

course of the pandemic remains high. A 

study conducted by the Hamburg-Eppendorf 

University Hospital did however find 

a small but significant improvement in the 

mental health of children. 

With regard to mental health, the microbiome 

is also deserving of special attention. 

This microbial community influences 

the way food is digested, the activity level 

and fitness of the immune system, and the 

functioning of the central nervous system. 

A number of illnesses are being linked to a 

disturbed microbiome today. 

Functional substances not only contribute to sound digestion and 

intestinal health as well as strengthening the body’s defences, they 

also increase the availability of minerals such as calcium, magnesium, 

iron and zinc. 

The importance of omega-3 fatty acids has long since been proven, 

along with their tremendous significance in sports. They have a positive 

effect on brain development in children, and can boost cognitive 

flexibility and therefore also counteract dementia. Supplementing 

with omega-3 fatty acids can considerably improve the anti-oxidative 

capacity in case of macular degeneration due to age. This also 

applies to taking micronutrients. 

Combining all of these topics already gets us very close to overall 

well-being. Surprisingly, many of these things are related and influence 

each other. 

I wish you an interesting read! 

Warmest regards, 

Silke Watkins 

The microbiome makes an important contribution 

to human health. Studies point to a 

connection between a healthy microbiome 

and healthy skin, but also healthy ageing 

and a longer life. 

No. 1 April/May 2022 

3

Contents 

Health 

Convenience Food 

Food & Beverages 

Confectionary 

Cover Photo © : Indena S.p.A. 

More than 150 million people annually (1), are affected 

by urinary tract infections (UTIs) which are among the 

most frequent infections in clinical practice worldwide. 

UTIs can affect any part of the urinary system although 

the organs where they most frequently develop are the 

bladder and urethra. Cranberry products have beneficial 

role for urinary tract wellbeing because they can 

control R-UTIs episodes frequencies, as observed by 

several studies. The complex mixture of proanthocyanidins 

(PACs), flavonols and phenolicacids contained in 

cranberry extract seems to level biofilm formation and 

tissues pricking.(see Cover story at page 6) 

Sports Nutrition 

Health Care 

Personal Care 

Contents 

Cover story 

06 Urinary health maintenance, a goal for millions of people 

Functional ingredients in gut health 

08 Naticol ® Gut: a key ingredient in gut health 

Dietary fibres and overall wellbeing 

12 More than gut health: Fibre contributes to overall wellbeing 

Microbiome 

15 Gut health 2.0 – The increasing role of the microbiome 

Bioactives for stress and sleep wellbeing 

19 Lactium ® , a natural bioactive for mental wellbeing praised by its consumers! 

Marine ingredients in sports nutrition 

20 A small revolution is underway in the world of lipids and marine ingredients 

Ceramides for skin health 

23 Ceramides: science supported lipids for skin health 

AMD and micronutrients 

26 Age-related macular degeneration: Micronutrients for prevention and therapy 

Minerals in sports nutrition 

32 Minerals in sports nutrition 

Active ingredients 

37 A “new generation” of liposomes 

Antioxidants in baked goods 

40 Natural solutions in baked goods. From early civilizations to modern innovation! 

Oils and fats 

43 Virgin coconut oil and MCT oil: effective energy suppliers 

Vitafoods Europe 

46 Vitafoods Europe returns in May 2022 

48 Vitafoods Europe – Preview 

50 Impressum 

4 No. 1 April/May 2022

VIVA 

VITAFOODS! 

The world‘s nutraceutical event 

10–12 May 2022 Geneva 

Experience the latest trends and technologies 

in food supplements at the Vitafoods Europe 

trade fair, and visit us at VIVATIS booth I60! 

➜ Discover new delivery technologies and innovative product formats 

➜ Find out about our branded ingredients and their best formulations 

➜ Learn more about the newest member in the VIVATIS family: Probionova – 

our partner for innovative probiotic solutions 

WWW.VIVATIS.DE | NE@VIVATIS.DE | +49 (0)40 236 90 90

Cover story 

Photo © : Adobestock/eAlisa 

Urinary health maintenance, a goal 

for millions of people 

With Indena’s Anthocran ® Phytosome ® let’s shed new light on urinary tract health, 

enhancing cranberry potential 

More than 150 million people annually (1), are affected by urinary 

tract infections (UTIs) which are among the most frequent infections 

in clinical practice worldwide. UTIs can affect any part of the urinary 

system although the organs where they most frequently develop are 

the bladder and urethra. 

Such infections create clinical and economic burdens on healthcare 

systems, and negatively influence individuals’ quality of life as well. 

Recurrent lower urinary tract infections (R-UTIs) are common after 

urinary catheterization in surgical patients, but they may occur also 

in non-surgical patients, particularly in women, and are also common 

in men. 

Cranberry products have beneficial role for urinary tract wellbeing 

because they can control R-UTIs episodes frequencies, as observed 

by several studies. The complex mixture of proanthocyanidins 

(PACs), flavonols and phenolicacids contained in cranberry extract 

seems to level biofilm formation and tissues pricking. 

On the other hand, cranberry extract presents 

a problem of poor availability and bioabsorption, 

like many other natural compounds. 

That’s why Indena has developed a new 

health-food ingredient based on Phytosome ® 

formulation proprietary technology, able to 

enhance and optimize the delivery of Indena’s 

cranberry extract (Anthocran ® Phytosome ® ) 

where the effects are needed. 

In addition to its better ability to reach tissues, 

thanks to the phytosome ® 100 % food grade 

formulation, cranberry extract (Anthocran ® 

Phytosome ® ) boasts a unique phytochemi cal 

characterization, which makes it the highest 

quality cranberry extract on the market; 

infact, it is standardized in proanthocyanidins 

(PACs: 6.0-9.0 % UV-visible spec- 


Cover story 

trophotometric contents – DMAC method) 

and contains the full polyphenols profile of 

natural cranberry, including flavonols, anthocyanins 

and phenolic acids. 

A recent human urines pharmacokinetics 

study (2) has been done with the aim to 

profile, by using an HPLC-MS/MS method, 

cranberry compounds and metabolites 

found in human urine after supplementation 

of a highly standardized cranberry extract: 

Anthocran ® Phytosome ® . Two different strategies 

were adopted for the data analysis: a 

targeted and an untargeted approach. These 

strategies allowed the identification of 42 

analytes including cranberry components, 

known metabolites and metabolites hitherto 

unreported in the literature, including eight 

valerolactones/valeric acid derivatives whose 

presence in urine after cranberry consumption 

has never been described before. 

Moreover, the ex vivo study showed that urine 

fractions rich in these metabolites are the 

most active against the pathogen Candida 

so frequent in hospitalized patients; it can 

reach the 10 % of positive urine cultures in 

hospitals, intensive care units and tertiary 

care facilities. 

To support from a clinical point of view 

these interesting data, a pilot registry study 

(3) recently investigated the effects of the 

oral supplementation of a standardized 

Anthocran ® Phytosome ® for the support of 

urinary tract health. 

reported to have a more favorable actions in managing UTI discomforts 

(like urinary frequency, urinary urgency, dysuria and nocturia), 

as assessed on the visual analogue scale, compared with subjects in 

the standard management or nitrofurantoin groups. 

No subjects with blood in urines and with traces of bacterial infection 

in urine in the group treated with the supplement compared with 

controls (p < 0.05). The cranberry extract was also superior to the 

control management in terms of recurrence of signs, with none of the 

subjects in this group reporting a R-UTI in the 3-months following the 

study end (p < 0.05). 

The supplementation showed an optimal safety profile, with no significant 

adverse events and no drop-outs in the supplement group. 

The study shows that cranberry extract (Anthocran ® formulated as 

Phytosome ® ) is a valid diet supplementation for subjects where postoperative, 

post-catheter R UTIs may occur, whit a good tolerability 

profile. 

References 

1 World J Urol. 2020 Nov;38(11):2669-2679. doi: 10.1007/s00345-019-03071-4. 

Epub 2020 Jan 10.) 

2 Giovanna Baron et alii, Biochemical Pharmacology 173 (2020) 113726 

3 Roberto Cotellese, Andrea Ledda, Gianni Belcaro, Maria R. Cesarone, Claudia Scipione, 

Valeria Scipione, Mark Dugall, Beatrice Feragalli, Antonella Riva, Pietro Allegrini, 

Giovanna Petrangolini & Stefano Togni (2021):, DOI: 10.1080/19390211.2021.1972074 

For more information, please contact 

Laura Bo 

External Communication and 

Sustainability, Indena S.p.A. 

laura.bo@indena.com 

www.indena.com 

The study included 64 otherwise healthy 

subjects who underwent a surgical procedure 

and required post-surgical urinary 

catheterization. The subjects have been 

divided by randomization in four groups: 

12 subjects were given supplementation 

with the standardized cranberry extract at 

the dose of either 120 mg/day, 12 subjects 

at 240 mg/day, 18 subjects were assigned 

to a control group consisting of standard 

management and 22 to a group with nitrofurantoin 

administration for four weeks to 

relief the R UTIs. 

At the end, subjects receiving the standardized 

cranberry Phytosome ® supplementation 


7


Naticol ® Gut: a key ingredient in gut health 

Weishardt patented fish collagen peptides modulate intestinal inflammation 

Mouna Rahabi, PhD 

Inflammatory bowel diseases (IBD) are chronic inflammatory 

diseases affecting the gastrointestinal tract. Remaining 

largely unclear, the etiology of IBD involves a complex interaction 

between genetics, environmental and microbial 

factors and immune responses 1 . 

In fact, there is clear evidence that the prevalence of IBD is associated 

with the environment as demonstrated by a north-south gradient 

of the disease prevalence which is markedly higher in industrialized 

countries. The rapid incidence increase of IBD over the last decades 

is believed to be associated with the introduction of the “western diet” 

across the world. Indeed, diet can influence intestinal inflammation 

by different pathways essentially by altering gut microbiota, affecting 

gut permeability or triggering immune responses 2 . Thus, it appears 

that nutrients intake can modulate gut inflammatory status. Although 

many approaches focus on the use of probiotics in intestinal inflammation, 

only few studies target nutrients such as collagen peptides 

in this context 3 . 

Besides, an important number of studies 

have been conducted to demonstrate 

the anti-inflammatory activity of collagen 

peptides in osteoarthritis but, until now, there 

was no clear evidence on their impact on 

intestinal inflammation. 

Naticol ® Gut 

Weishardt scientific team has worked on 

transposing fish collagen peptides bioactivity 

to gut inflammation and provide today solid 

evidence that the new patented Naticol ® 

Gut fish collagen peptides have a beneficial 

effect in this axis. Indeed, Naticol ® Gut 

reduces experimental colitis severity in an 

immune system-dependent manner that 

consequently leads to a healthier gut micro- 



biota. These complete pre-clinical results are corroborated by the 

very encouraging fact that Naticol ® Gut also restores the anti-inflammatory 

phenotype of immune cells from subjects suffering from IBD. 

Naticol ® Gut displays an anti-inflammatory 

and anti-oxidant activity in gut 

Gut immune system is largely involved in the inflammatory status of 

gastric tract. Among immune cells, macrophages represent a population 

that plays a key role in gut balance. In physiological conditions, 

gut macrophages do not react to the gut microbiota thereby 

avoiding inappropriate immune reactions. Conversely, in IBD there 

is a massive infiltration of macrophages leading to the rupture of the 

intestinal barrier by displaying pro-inflammatory and pro-oxidant 

activities 4 . The experimental model of colitis in which Naticol ® Gut 

activity was assessed, is based on a chemical induction (Dextran 

Sodium Sulfate, DSS) of intestinal inflammation with symptoms 

and biological changes that can be assimilated to human ulcerative 

colitis 5 . Interestingly, Naticol ® Gut-treated DSS mice displayed a lower 

degree of colonic inflammation as reflected by less immune cells infiltrate, 

crypts loss, and epithelial erosion on histological sections of the 

colon (Fig. 1). 

Photo © : istockphoto/shironosov 

Fig. 1: Histological staining of representative cross-sections of colon 

Furthermore, it is demonstrated that Naticol ® Gut is able to switch the 

phenotype of colonic inflammatory macrophages generated by DSS 

administration towards an anti-inflammatory and anti-oxidant pheno- 

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Gut microbiota represents one of the most incriminated components 

in IBD development. Indeed, in intestinal inflammation, there 

is a disruption of the harmonious relationship between the microbiota 

and the immune system. Microbiota becomes unbalanced 

and immune system overactivated. The unbalanced microbiota, 

called dys biosis, is characterized by an increase of the “aggressive” 

species and a impoverishment in the probiotic species 7 . Interestingly, 

Naticol ® Gut administration consistently decreases the burden 

of “bad” bacteria and yeast such as Escherichia coli or Candida 

albicans while it enriches populations of protective bacteria and 

yeast such as Saccharomyces cerevisiae or Lactobacillus sp. Our 

study demons trates that this modulation of gut microbiota is exerted 

through the effect of Naticol ® Gut on the immune system via a crosstalk 

between both components 6 (Fig. 3). 

Fig. 2: Cytokine expression by macrophages 

##p ≤ 0.01, ###p ≤ 0.005, ####p ≤ 0.001 DSS-exposed mice compared 

to DSS-exposed mice treated with Naticol ® Gut 

type (Fig. 2). This effect on macrophages reverberates on the whole 

immune system as the global pro-inflammatory mediators’ production 

is significantly dampened by Naticol ® Gut 6 . 

Naticol ® Gut impacts gut microbiota 

Fig. 3: microbiota fluctuation 

#p ≤ 0.05, ##p ≤ 0.01, DSS-exposed mice compared to DSS-exposed mice 

treated with Naticol ® Gut 

Conclusion 

The use of functional ingredients in gut health management is an 

emerging concept. In this context, Weishardt provides solid preclini 

cal results as well as an encouraging translational approach using 

immune cells directly collected from human subjects and in which 

results show that Naticol ® Gut restores an anti-inflammatory profile. 

Last but not least, Weishardt has taken the science behind fish 

collagen peptides to a deeper level of understanding by highlighting 

the mechanism by which Naticol ® Gut exerts its beneficial effects. 

References 

1 

Actis, G. C., Pellicano, R., Fagoonee, S. & Ribaldone, D. G. History of Inflammatory Bowel 

Diseases. J. Clin. Med. 8, 1970 (2019). 

2 

Rajendran, N. & Kumar, D. Role of diet in the management of inflammatory bowel disease. 

World J. Gastroenterol. WJG 16, 1442–1448 (2010). 

3 

Rossi, R. E. et al. The role of dietary supplements in inflammatory bowel disease: a 

systematic review. Eur. J. Gastroenterol. Hepatol. 28, 1357–1364 (2016). 

4 

Kühl, A. A., Erben, U., Kredel, L. I. & Siegmund, B. Diversity of Intestinal Macrophages in 

Inflammatory Bowel Diseases. Front. Immunol. 6, (2015). 

5 

Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium 

(DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, 15.25.1-15.25.14 (2014). 

6 

Rahabi, M. et al. Bioactive fish collagen peptides weaken intestinal inflammation by 

orienting colonic macrophages phenotype through mannose receptor activation. Eur. J. 

Nutr. (2022) doi:10.1007/s00394-021-02787-7. 

7 

Ni, J., Wu, G. D., Albenberg, L. & Tomov, V. T. Gut microbiota and IBD: causation or correlation? 

Nat. Rev. Gastroenterol. Hepatol. 14, 573–584 (2017). 

Photo © : Shutterstock/rangizz 


WEISHARDT International 

81300 Graulhet, France 

Phone +33 5 63 42 14 41 

welcome@weishardt.com 

www.weishardt.com 


Connect with 

nutraceutical 

experts 

This year, Vitafoods Europe 2022 returns to its annual 

May slot in your diary. As it’s a hybrid event you’ll be 

able to join us in person and online to share ideas, 

see new products, source ingredients and innovate 

with an inspiring community of experts. This is your 

chance to connect with industry-leading buyers, 

suppliers and manufacturers from over 110 countries, 

so don’t miss it. 

Register for your free 

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Photo © : Shutterstock/Monkey_Busines 

More than gut health: Fibre contributes 

to overall wellbeing 

Natural fibre Sunfiber ® counteracts dietary deficiencies – even in those with digestive problems 

Dr Stefan Siebrecht 

For a long time, dietary fibre was thought of as useless and 

even burdensome because of its indigestible properties – until 

the first indications of its positive effects on the body emerged. 

Nowadays, those previously held opinions have been overturned, 

and experts recommend integrating “dietary fibre” into 

the diet in much larger quantities for a variety of reasons, from 

digestive health to emotional wellbeing. 

The World Health Organisation (WHO) recommends a daily intake 

of 30 g of dietary fibre. In most European countries, however, the 

average consumption is far below this amount. If you look at the fibre 

content of popular foods – avocados, for example, contain about 7 g 

of fibre per 100 g, and apples about 2 g per 100 g – it becomes clear 

that the modern eating habits and taste preferences of Western diets 

are not sufficiently balanced when it comes to fibre intake. Important 

sources such as whole grains, legumes, fruits and vegetables 

are not consumed in sufficient amounts to 

meet daily requirements. 1 Therefore, fortifying 

or supplementing foods and beverages 

with dietary fibre offers a promising approach 

to improving overall intake and, thus, the 

general health of the population. 

Prebiotic ingredients like Taiyo’s partially 

hydrolysed guar gum (Sunfiber ® ) make it easy 

to add fibre to all sorts of foods and beverages, 

and fortified products are a pleasant way for 

consumers to boost their health and wellbeing. 

Sunfiber ® is easy to process, its positive effect 

on the digestive tract is scientifically proven, 

and foods containing it can be labelled with 

the EU Nutritional Claim “high in fibre”. 



The importance of dietary fibre 

Scientific research has repeatedly shown 

that our overall health depends to a large 

extent on the health of the gut, which is home 

to about 100 trillion bacteria from 1,000 

different species. This “microbiome” has 

many functions, including supporting digestion, 

nutrient absorption and the immune 

system. Studies in recent years have also 

confirmed that the gut is in direct contact 

with the emotional centre of the brain. By 

changing the gut microbiome, it has been 

proven that neurobiochemistry, behaviour 

and even personality can be significantly 

altered. 2 

The microbiome is directly affected by what 

we eat: a high-sugar, low-fibre diet feeds 

harmful bacteria, while a diet high in fibre 

and low in sugar has the opposite effect: It 

supports beneficial gut bacteria diversity to 

help regulate blood sugar, fight inflammation 

and produce the substances required for a 

healthy brain. 

After consuming dietary fibre, blood glucose 

levels rise only moderately and remain 

constant for a lengthy period of time, during 

which the body needs less insulin. As a 

result, there is an increased feeling of satiety, 

with hunger pangs kept at bay for longer. 

Fibre can therefore play an effective role in 

weight management. In addition, fibre intake 

promotes the production of digestive juices, 

which have a stimulating effect on general 

intestinal movements. This means that the 

transit time of food in the digestive system 

is shortened, which can, in turn, reduce the 

risk of bloating and haemorrhoids. 

Recent studies show that dietary fibre can 

also help to prevent colon and prostate 

cancer because carcinogenic substances 

are diluted and harmful substances excreted 

more quickly. 3 One reason for this is that the 

body cannot break down the plant components 

of dietary fibre enzymatically, so they 

enter the colon undigested. Here, they serve 

as food for gut bacteria such as lactobacilli 

and bifidobacteria. These beneficial bacteria 

multiply, increase stool volume and thus 

help prevent constipation. 

A healthy intestinal microbiome is an essential prerequisite for a 

fully functioning immune system too. For instance, it helps to regulate 

inflammatory cascades in the body and forms a physical barrier 

against potential invaders such as pathogenic bacteria, viruses and 

parasites. 

Furthermore, in a healthy body, the fermentation of dietary fibre 

produces the short-chain fatty acids acetate, propionate and butyrate. 

These are partially absorbed and transported to the liver, where they 

inhibit the formation of cholesterol. The short-chain fatty acids also 

supply the cell membranes with energy and improve the absorption 

of minerals. 

Supporting health and wellbeing 

Taiyo, an expert in natural ingredients with added health value, has 

been pioneering fibre research for more than 20 years. The company 

develops and produces a wide variety of functional ingredients, 

including the 100 per cent natural dietary fibre Sunfiber ® . Designed to 

close the dietary fibre gap, this ingredient combines nutritional benefits 

with health-promoting properties. Sunfiber ® is a soluble prebiotic 

fibre that has been shown in numerous studies to help improve the 

activity and proliferation of beneficial probiotics in the gastrointestinal 

tract, which are essential for overall health and wellbeing. In addition, 

its fermentation rate is very slow, which means it does not trigger 

painful bloating, cramping or discomfort. 

Sunfiber ® not only contributes to healthy digestion, but also offers a 

range of clinically proven health benefits for the entire body. When 

consumed with a meal, it improves the absorption of minerals such 

as calcium and magnesium. 4 It also slows and reduces the absorption 

of fat, cholesterol and sugar. 5 Additionally, it has been shown in 

clinical studies to lower the glycaemic index, thus helping to stabilise 

blood sugar levels. For this reason, Sunfiber ® has been awarded a 

health claim by Canadian health authorities for reducing blood sugar 

levels by 20 per cent after a meal. 6 

Photo © : Shutterstock/Paisit Teeraphatsakool 


13

Dietary fibres and overall well-being 

Low FODMAP diet-compatible 

Sunfiber ® is suitable for people who follow a low FODMAP diet, as 

well as for patients with irritable bowel syndrome (IBS). The term 

FODMAP stands for fermentable oligosaccharides, disaccharides, 

monosaccharides and polyols. These are poorly digestible shortchain 

carbohydrates such as lactose, fructose, sugar alcohols such 

as sorbitol, and many other indigestible carbohydrates found in 

fruits and vegetables. FODMAP components are fermented by the 

intestinal flora. This process is thought to trigger gastrointestinal 

symptoms such as bloating, diarrhoea, constipation and cramps 

in sensitive people. A clinical study published in 2010 reported the 

positive effect of a low FODMAP diet on the symptoms of conditions 

such as IBS. 7 A diet low in FODMAP compounds such as fibre is 

therefore often recommended for patients with digestive disorders. 

However, avoiding fibre compromises the foundation for good gut 

health. For these people, Sunfiber ® can bridge the nutritional gap 

by providing a soluble and prebiotic fibre that is compatible with a 

low FODMAP diet. 

Naturally certified 

Taiyo’s focus is on natural ingredients with added health value. Over 

the years, the company has established itself as a leading manufacturer 

of functional ingredients for the food and pharmaceutical industries. 

Naturalness plays a central part in this: Sunfiber ® is made from 

partially hydrolysed Indian guar gum (PHGG). The galactomannan 

fibre is colourless, odourless and tasteless, and is suitable for a variety 

of applications. It can be easily incorporated into existing recipes and 

is suitable for use in a wide range of foods and beverages, including 

bakery, dairy and confectionery, as well as meat and savoury products. 

Other potential applications include dietary supplements and 

instant or ready-to-drink beverages. The non-viscous guar bean fibre 

does not change the consistency or flavour of the products to which 

it is added. 

As the fibre is 100 per cent soluble, it dissolves completely in water 

and other hot and cold beverages, including smoothies. It has been 

used as a dietary supplement in clinical and enteral nutrition for 

several years, and is available in different qualities, depending on the 

desired application and requirement. Sunfiber ® is also pH, heat and 

thaw stable. 

It meets the dietary fibre definition of the FDA 

(US Food and Drug Administration), and a 

food or beverage product can be labelled 

as high-fibre if it contains at least 6 g of the 

ingredient per 100 g or at least 3 g per 100 

kcal. Taiyo also places the highest demands 

on the entire supply chain, with all seeds 

used being chemically untreated and GMOfree. 

Furthermore, no preservatives are used 

or added during processing. Sunfiber ® is ISO 

certified for its natural production process, 

as well as kosher and halal certified, and is 

suitable for vegetarian and vegan diets. 

References 

1 

Andrei, Mihai: WHO report: You should eat 25g of fiber every 

day – and you probably don’t. ZME Science, 15.01.2019, 

https://www.zmescience.com/science/who-report-fibers- 

14012019/#:%7E:text=A%20new%20report%20 

published%20by,swarm%20of%20other%20health%20 

issues. (accessed on 24.03.2022) 

2 

K. M. Neufeld, et al.: Reduced Anxiety-like Behavior and 

Central Neurochemical Change in Germ-free Mice. Neurogastroentereol 

Motil 23. no. 3 (March 2011): 255-64, e119 

3 

Diet and Cancer Report downloads: WCRF International, 

15.03.2022, https://www.wcrf.org/dietandcancer/ 

resources-and-toolkits/ (accessed on 16.03.2022). 

4 

H. Hara, et al. Increases in Calcium Absorption with 

Ingestion of Soluble Dietary Fibre, Guar-Gum Hydrolysate, 

Depend on the Caecum in Partially Nephrectomised and 

Normal Rats. British Journal of Nutrition 76, 773–784 

(1996). 

5 

M.P. Kapoor, et al. Soluble Dietary Fibre Partially Hydrolysed 

Guar Gum Markedly Impacts on Postprandial Hyperglycaemia, 

Hyperlipidaemia and Incretins Metabolic 

Hormones Over Time in Healthy and Glucose Intolerant 

Subjects. Journal of Functional Foods 24, 207–220 (2016). 

6 

Confirmed by the Bureau of Nutritional Sciences, Food 

Directorate, Health Canada, Ottawa 25. April 2013. 

7 

P.R. Gibson and S.J. Shepherd. Evidence-Based Dietary 

Management of Functional Gastrointestinal Symptoms: 

The FODMAP Approach. J. Gastroenterology. Hepatic. 25(2), 

252–258 (2010). 


Dr Stefan Siebrecht 

Managing Director at Taiyo GmbH 

s.siebrecht@taiyogmbh.com 

www.taiyogmbh.com 


Microbiome 

Photo © : Madhouse 

Gut health 2.0 – The increasing role 

of the microbiome 

Diana Kalustova 

Super organ, superorganism, or the 

forgotten organ – the human microbiome 

is called by many names. And 

all of them reflect how important this 

“community of microorganisms” is for 

the natural everyday functioning of the 

human body. But what exactly is the 

microbiome? And what is it actually 

good for? 

The human microbiome consists of trillions 

of microorganisms. These include 

not only bacteria, but also fungi, parasites, 

and viruses. While many of the microorganisms 

have not yet been identified, scientists 

believe that well over 1,000 different ones 

live on us and in us. Each person has their 

individual fingerprint of the intestinal microbiota, 

determined by one’s DNA 1 . However, 

some microorganisms are found in each and 

every one of us. 

The intestine plays a unique role. By far, the most significant part of 

the human microbiome is found here. This is where a high microbial 

density meets the intestine-associated lymphoid tissue, which 

controls the entire body’s immune response. 

Microbes are generally not harmful to us. Rather, they are essential 

for maintaining good health. For example, they produce specific vitamins, 

break down our food to extract nutrients, teach our immune 

system to recognize dangerous invaders, and produce helpful antiinflammatory 

compounds that ward off other disease-causing 

microbes. 

It is not only experts who recognize the ever-increasing importance 

of the microbiome. Consumers also embrace the microbiome as an 

opportunity to maintain and improve their health. As a result, market 

research provider Fortune Business Insights predicts that the global 

digestive health market will grow at a compounded annual growth 

rate of 7.9 % to reach 71.95 billion US dollars by 2027. Several 

factors are driving this growth. One of them is the increasing incidence 

of digestive disorders, which are now seen in up to 40 % of the 

world’s population. 


15

Microbiome 

It is now a generally accepted consensus that changes in the composition 

of our microbiome are associated with numerous diseases. This 

means that altering and enriching the microbiome can be used to 

maintain health and treat diseases. In particular, the gut microbiota 

critically intervenes in metabolism, immune system maturation, and 

the function of the central nervous system. This makes the microbiome 

a critical organ that influences the entire body. 

Gut Health 2.0 goes beyond digestion. Instead, it takes a holistic 

approach to health. Current research topics such as gut-immunity 

axis, gut-brain axis, gut-skin axis or gut-heart axis show the almost allencompassing 

significance of the human gut microbiome for human 

health. Axes represent the connections between the gut and individual 

human organs. 

An increasing number of studies demonstrate the incredible potential 

of the microbiome for various bodily functions. For example, it is 

now well established that a healthy microbiome is directly related to 

the skin’s health. As a multifunctional organ, it requires many micronutrients 

that are absorbed through the gut. Similarly, a dysfunctional 

microbiome is often closely related to metabolic diseases such as 

type 2 diabetes mellitus 2 . 

The microbiome also regulates the fitness of the immune system 3 . 

Healthy ageing and a longer life are also linked to the microbiome. 

A recent study 4 carried out in the United States shows that a high 

level of uniqueness and diversity of the microbiome is associated with 

increased survival. The microbiome-gut-brain axis takes on particular 

importance in studies. It is becoming clear that the composition and 

metabolism of the microbiome not only exert an important influence 

on mental disorders but also affect weight regulation. 

GUT-BRAIN AXIS 

GUT MICRO- 

BIOTA 

G U T - S K 

HPA 

GUT- 

BRAIN- 

SKIN 

AXIS 

I N 

BRAIN-SKIN AXIS 

A X I S 

PSORIASIS 

Even fitness and musculature are closely linked to the microbiome. 

For example, Swedish researchers 5 from the Karolinska Institute in 

Stockholm discovered in mice experiments that gut bacteria strongly 

influence normal skeletal muscle function. In any case, a holistic 

view of the body is essential for maintaining and improving health. 

The latest scientific findings show that a 

well-functioning, diverse microbiome has a 

central role as a control instrument for many 

aspects of the human body. 

Prebiotics, probiotics, synbiotics, 

and postbiotics: 

the supporters of the microbiome 

When something is as essential as the microbiome, 

we should do everything we can to 

keep it in good shape. Fortunately, the 

digestive system comprises several built-in 

supporters for this: 

Probiotics – the viable microorganisms that 

multiply in the gut and, in sufficient quantities, 

impart health benefits to the host. 

Prebiotics – the non-digestible food components 

that boost growth and activity of ba 

cteria in the colon. They also block the 

binding of harmful bacteria. 

Synbiotics – a combination of probiotics and 

prebiotics that synergistically combines the 

benefits of both. 

Postbiotics – byproducts of the fermentation 

process. These are soluble factors secreted 

by live bacteria or released after bacterial 

lysis and provide physiological benefits to the 

host. However, for many scientists, the definition 

of postbiotics was not clear enough. In 

2021, seeking clarity on what qualifies as a 

postbiotic, a panel of experts at the International 

Scientific Association of Probiotics and 

Prebiotics (ISAPP) sought a new definition 6 . 

They defined a postbiotic as a “preparation 

of inanimate microorganisms and/or their 

components that confers a health benefit on 

the host”. 

Prebiotics – much more than 

a trendy product 

The demand for advanced prebiotics that 

have no side effects and are intended 

to support specific areas in the body is 

increasing permanently. Certain prebiotics 

are particularly beneficial for the microbiome. 

They target particular bacteria, which 

produce a high amount of short-chain fatty 

acids. SCFAs do not have to be modified 

during digestion and absorbed directly by the 

body. According to current research, shortchain 

fatty acids serve as “food”, especially 


Microbiome 

for those intestinal bacteria with a particular 

protective function. They can prevent inflammation 

in the body and protect against an 

attack by the human organism on the body’s 

cells, the cause of numerous autoimmune 

diseases such as multiple sclerosis, psoriasis, 

rheumatism, or allergies. In addition 

to strengthening the immune system, shortchain 

fatty acids could also help make bones 

more stable, alleviate joint inflammation, 

lower cholesterol levels or reduce appetite. 

An expanding range of candidate probiotic 

species and prebiotic substrates is 

emerging to address newly elucidated datadriven 

microbial niches and host targets. 

New variants of microbiome-modulating 

interventions are developing overlapping 

with, and adjacent to, the probiotic and 

prebiotic fields. Personalized nutrition and 

precision medicine are increasingly influencing 

the targeting and use of probiotics 

and pre biotics. As a result, the modulation 

of microbial signatures towards finding the 

appropriate “piece of the puzzle” to maintain the health of specific 

functions or to combat individual disease states is increasing. 

High-quality, tested synbiotics can be 

the best of both worlds 

Nowadays, live microorganisms are increasingly used with special 

dietary fibers to combine their health benefits. However, one must 

keep in mind that the combination of prebiotics and probiotics is 

not always beneficial, as not all of them go together. In any case, it 

is crucial to find a high-quality, tested combination. Besides, many 

people do not tolerate specific prebiotics well. Many soluble prebiotics 

are broken down too quickly by the intestinal flora, possibly 

leading to flatulence, bloating, and abdominal pain. 

Two examples of new-generation prebiotics that 

combine perfectly with probiotics 

Sunfiber ® is a water-soluble bean fiber derived from the guar bean. 

This is a galactomannan fiber (partially hydrolyzed guar gum, PHGG) 

that is very low viscous and non-gelling. It is a perfect ingredient for 

patients with irritable bowel syndrome and functional gastrointestinal 

disorders. Sunfiber ® is the first dietary fiber certified by Monash 

University as a low-FODMAP dietary fiber (fermentable oligosaccha- 

20% 

C 

LIPOSOMAL VITAMIN 

HIGH STABILITY AND BIOAVAILABILITY 

READY-TO-USE SOLUTION 

LIQUID FORM : 

OPTIMAL EFFICIENCY / ABSORPTION 

THE SOLUTION CAN BE FLAVOURED 

Made in France 

+33(0)2.98.50.41.60 // contact@capsularis.com

Microbiome 

rides, disaccharides, monosaccharides, and polyols). The effect of 

Sunfiber ® on diet-related diseases has been demonstrated in more 

than 150 studies. For example, in a recent internal report 7 together 

with Probionova ® , the results for Lactobacillus spp. indicate that 

almost all microorganisms can actively grow in the presence of 

Sunfiber ® . 

MicrobiomeX ® is an example of a fruit extract with high flavonoid 

content and prebiotic effect. This first-in-class product combines 

active ingredients from Citrus Sinensis (Orange) and Citrus Paradisi 

(Grapefruit). The unique complex is specifically designed to positively 

alter the gut microbiome to support gut health and immune system, 

reduce intestinal inflammation and strengthen the gut barrier. MicrobiomeX 

® has been validated in multiple proprietary studies showing 

a dose-dependent beneficial effect with a daily intake ranging from 

250 to 500 mg. In addition, the significant shift in SCFA profile and 

the lower calprotectin levels observed suggest a decreased pathogen 

load in the gut. 

Probionova is one of the most innovative 

companies focusing on the microbiome by 

developing new probiotic applications. The 

young, future-oriented partner company of 

Vivatis ® maintains a leading scientific position 

in the research and development of 

new probiotics/synbiotics. With its in-depth 

experience, the company can select the 

best strain or an optimum synergy of the 

available strains to provide customers with 

the highest quality standards and customized 

offers. Probionova ® has specialized in 

responding to the most diverse wishes and 

requirements for probiotics products. The 

range extends from various unique probiotic 

strains to finished products that are good for 

the microbiome. 

Difference in Butyrate/total SCFA ratio 

after 12 weeks of intervention 

Butyrate & total SCFA ratio 

0.025 

0.02 

0.015 

0.01 

0.005 

0 

-0.005 

-0.01 

-0.015 

Intervention 

Placebo 

MicrobiomeX ® 

* 

*Significant effect on SCFA ratio 

after daily application of MicrobiomeX ® 

Today, customized product solutions are increasingly in demand 

for prebiotic and probiotic products instead of all-in-one products. 

They make it easier to meet the diverse requirements of the human 

organism, minimize side effects and provide targeted support for 

specific areas. The current state of research and product development 

is bringing into light a growing number of facts about the diversity 

of probiotic strains. They are designed or synergistically combined 

with high quality and concentration for the application and function. 

References 

1 

“Identifying personal microbiomes using metagenomics 

codes”, Eric A. Franzosa, Katherine Huang, James 

F. Meadow, Dirk Gevers, Katherine P. Lemon, Brendan JM 

Bohannan, Curtis Huttenhower, 

2 

“Arrhythmic Gut Microbiome Signatures Predict Risk of 

Type 2 Diabetes” 

3 

Schaupp L et al. Microbiota-induced type I interferons 

instruct a poised basal state of dendritic cells. Cell 2020 

Mai 06. doi: https://doi.org/10.1016/j.cell.2020.04.022 

4 

Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., 

Wiedrick, J., Lapidus, J., & Price, N. D. (2021). Gut microbiome 

patternreflects healthy ageing and predicts survival 

in humans. Nature metabolism, 3(2), 274-286. 

5 

“The gut microbiota influences skeletal muscle mass and 

function in mice”, Shawon Lahiri et al.; Science Translational 

Medicine, DOI: 10.1126/scitranslmed.aan5662 

6 

Aguilar-Toalá, J. E. et al. Postbiotics — when simplification 

fails to clarify. Nat. Rev. Gastroenterol. Hepatol. 

https://doi.org/10.1038/s41575-021-00521-6 (2021). 

7 

“Probionova report” (2020) Evaluation-of-the-prebioticpotential-of-Sunfiber 


Diana Kalustova, 

Business Development Manager Nutraceuticals, 

Vivatis Pharma GmbH 

Hamburg, Germany 


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19


A small revolution is underway in the world 

of lipids and marine ingredients 

Its name, Zooca Lipids or more precisely Calanus finmarchicus. 

This zooplankton is the primary biomass of the 

Arctic. From sustainable fisheries, it is harvested in Norway, 

above the Arctic circle and does not seem to fit into any 

box. Neither that of omega-3, nor that of krill oil. Let's dig 

into the story of this unique ingredient now distributed in 

France by Seanova: Zooca Lipids is about to revolutionize 

the sports industry. 

The tiny zooplankton Calanus finmarchicus is a dense pack of highperformance 

energy, utilized by the inhabitants of the Norwegian sea 

as their natural performance nutrition. 

The little auk, for instance, feed on Calanus finmarchicus during the 

short, arctic summer, to prepare for their long migrations during 

winter, where they often fly thousands of kilometres, all the way from 

Spitsbergen to Iceland and North- America. 

Why is Zooca Lipids, the natural oil from Calanus finmarchicus, 

such a powerful performance package of nutrients and energy? This 

natural oil is designed by nature to meet the 

needs of arctic creatures, who have very 

short time to prepare for harsh winter conditions 

and therefore depend on valuable 

nutrition. These benefits are now available to 

the athletes from the human world, as well. 

Let´s get a bit technical. What are some of 

the differences between Zooca Lipids 

and other fats? All lipids comprise a chain 

of carbon atoms bound to hydrogen atoms. 

Types of fat differ by the number of carbon 

atoms in the chain and the number and 

location of double bonds between them. 

Slight differences in structure may translate 

into critical differences in form and function. 

Fatty acids in krill oil are mostly bound to 

glycerol as phospholipids, whereas fatty 

acids in fish oils are present as triglyceri des. 



When it is time to perform, you must rely on your heart! Zooca 

Lipids benefits cardiac performance by enhancing the pumping efficiency 

of the heart, a benefit associated with the ergogenic properties 

of policosanols. Zooca Lipids also significantly increased max 

heart rate! Together, these effects mean more oxygen and nutrients to 

muscles and other cells in the body. No wonder that Zooca Lipids 

gains reputation among high-level athletes. 

Fig. 1: Chemical differences of Zooca Lipids, shown as wax esters 

vs. conventional lipids. 

The uniqueness of Calanus finmarchicus-derived lipids is the 

chemi cal form of liquid wax esters (Fig. 1). Described chemi cally, 

they are fatty acids esterified to policosanols (often called fatty alcohols, 

FAOH) as monoesters. Wax esters are distinctly different from 

fat in any other marine (or terrestrial) oils in terms of chemistry, bioactivity, 

and health benefits. 

Zooca Lipids benefits muscle performance because it contains 

ergogenic policosanols that helps optimizing muscle function as well 

as nature´s most powerful antioxidant astaxanthin, which mitigates 

muscles soreness by reducing oxidative stress in muscle tissue. By 

increasing fatty acid oxidation, the muscle glycogen can be spared, 

delaying onset of muscle fatigue and enhance performance. Zooca 

Lipids is a potent mix of numerous omega-3 fatty acids, which 

promotes muscle protein synthesis, aiding restitution and preparing 

your body for new efforts. 

Zooca Lipids also benefits muscle restitution and soreness on 

several levels. The rare omega-3 fatty acid Stearidonic Acid gives an 

extra anti-inflammatory dimension. Together with the classic omega-3 

fatty acids EPA and DHA, Stearidonic Acid forms a potent anti-inflammatory 

trio which mitigates inflammation and lays a good foundation 

for optimal healing, partly by inhibiting omega-6 conversion and 

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partly by being metabolized to anti-inflammatory Specialized Pro- 

Resolving Mediators, SPMs, and eicosanoids. Additionally, nature´s 

most powerful antioxidant astaxanthin reduces muscle-inflammation 

and soreness, leading to faster restitution and shorter time to the next 

full-intensity performance. 

Many athletes struggle to maintain their body in shape off season. 

This is the time of the season when you build the foundation for 

seasonal performance and muscles, heart, joints, and ligaments are 

exposed to extraordinary strain. During resting periods, it can be a 

challenge to maintain the body composition. 

Well, we have good news! Zooca Lipids benefits body composition 

and both fat reduction and muscle growth have been demonstrated 

in clinical trials. 

So, why is that so? Free fatty acid receptors are broadly regarded as 

nutrient sensors and are involved in the regulation of both inflammatory 

and metabolic processes. One of these is the GPR120 (also 

known as FFA4) receptor which is expressed in several tissues in the 

body, especially within the distal intestine and colon, as well as in 

adipose tissue and macrophages. This is a receptor for medium- and 

long-chain unsaturated fatty acids, including omega-3 fatty acids. 

Recent studies have shown GPR120 to play cardinal roles in metabolic 

disorders via modulation of gut hormone secretion and insulin 

sensitivity and body weight regulation. 

Whereas other dietary lipids claim their 

effects due to rapid absorption, Zooca 

Lipids explains it the other way around. The 

liquid wax esters from Zooca Lipids are 

slowly digested, resulting in delayed release 

of multiple bioactive molecules. The unique 

chemistry of these new and natural lipids 

allows them to withstand the first line of 

digestive enzymes, letting the lipids reach 

the distal part of the digestive tract without 

compromising the bioavailability of the fatty 

acids. When the liquid wax ester molecules 

ultimately are cleaved during digestion, the 

release of highly potent fatty acids activates 

GPR120 receptors present in the tissue and 

exert its effects. Whereas EPA and DHA are 

among the more potent of the common FAs 

on GPR120, Stearidonic acid, SDA, has 

recently been shown to be one of the most 

potent agonists on this central receptor. SDA 

is the predominant omega-3 fatty acid in 

Zooca Lipids! 

This receptor activation helps the body finetune 

metabolism of sugar and fat, making it 

easier to maintain the optimal body composition. 

Athletes report that it is easier to maintain 

the ideal body weight and body composition 

during off-season. 

If you think this was a bit complicated, we 

will make it easy for you. Summarized, what 

you need to know is that this natural powerpack 

of natural fats and nutrients from the 

zooplankton Calanus finmarchicus benefits 

muscle performance and restitution, heart 

pumping efficiency and body composition. 

So, do like the little auk: take Zooca Lipids 

with you on your sporting adventures! 

For more information and insight 

into clinical and preclinical results, 

please reach out to Seanova 

contact@seanova.fr 

www.seanova.fr 



Photo © : AdobeStock/Liubov_Levytska 

Ceramides: science supported 

lipids for skin health 

Lea Marchal 

As more and more information regarding 

ageing skin and its causes becomes 

available, consumer awareness continues 

to increase at an unprecedented 

high. The rise of Holistic Beauty 

observed for a few years, is a clear indication 

that consumers are now viewing 

lifestyle as an important factor in the 

appearance of their skin, including 

dietary interventions. To make the most 

of this opportunity in the Beauty-from- 

Within category, brands must develop 

food supplements based on ingredients 

with demonstrated efficacy, from 

natural origin, good for the consumers 

and more respectful of the environment. 

Seppic, designer of natural 

branded active ingredients for the 

nutricosmetics field, sheds light on a 

solution related to these major trends: 

phytoceramides. 

Ceramides: their role in skin health and youth 

The skin is a three-layer organ constituted of the hypodermis, the 

dermis, and the epidermis. The latter layer of the epidermis is called 

the stratum corneum and acts as a barrier against the exterior environment. 

The stratum corneum is made of skin cells, called corneocytes, 

and of lipids found in the intercellular spaces. The lipids are 

of different nature (cholesterol, free fatty acids,...) and ceramides are 

the major lipid species as they are represented at 50 % in the stratum 

corneum’s matrix. They have an essential and structuring role in skin 

health by supporting the skin barrier function and maintaining the 

water permeability of the skin. 

When skin reserves of water are preserved, the skin remains well 

moisturized and plump, preventing the apparition of cracks and 

scales. However, when we age, the skin becomes particularly thin 

and fragile with an impaired skin barrier. The stratum corneum of the 

skin, and more particularly its lipids, go through significant changes 

under the course of ageing, resulting in pigmentation spots, loss of 

elasticity, wrinkles and exacerbated dryness. These changes are now 

linked with a significant decrease in ceramides 1 . 


23


Opportunities to be leveraged 

in the Beauty-from-Within space 

A recent report from research firm Mordor 

Intelligence states that the global nutricosmetics 

market is estimated to register a 

CAGR of 8.05 % from 2021 to 2026 4 . The 

main factors driving the market are the rising 

consumer awareness regarding their skin 

problems, such as anti-ageing, wrinkles, hair 

loss, scalp problems, etc. These concerns 

are more and more associated with poor 

nutrition, making food supplements a go-to 

preventive beauty management practice. 

The preventive, holistic, and eco-conscious 

approach is delivering escalated growth of 

the skincare-from-within spacet, with offers 

that are based on clinically studied active 

ingredients. 

It is possible to deliver supplemental ceramides orally that provides the 

metabolites that are transported through the bloodstream to enable 

the skin to restore the ceramides levels in the stratum corneum. 

Ingestible ceramides to repair and 

strengthen the skin barrier 

Photo © : iStock/SrdjanPav 

Increasing usage of ceramides in cosmetics products provides now 

consistent evidence and awareness on topical ceramides efficiency 

in skin hydration and anti-ageing solutions. For the past decades, a 

strong scientific focus was observed to study ingestible ceramides, 

with evidence demonstrating that the oral use of ceramides is also 

highly effective at working to strengthen the skin barrier from within. 

A clinical trial on Ceramosides TM , a proprietary extract from Seppic 

that contains natural ceramides from wheat, reported significant 

improvement in skin moisturization by 16 %, skin elasticity by 18 % 

and skin wrinkles by 9 % compared to placebo in just 15 days 2 . 

Such a quick action is possible thanks to the composition of the 

ingredient in digalactosyl diglycerides (DGDG) combined with the 

presence of ceramides. Indeed, DGDG are natural emulsifiers shown 

to boost ceramides bioavailability and absorption, making ceramides 

building blocks available in the epidermis only 24 h after ingestion 3 . 

Ceramosides TM efficacy was also validated by the volunteers participating 

in the study, with 75 % of subjects noticing less pulling 

sensations 

In Europe, the demand for natural ingredients, 

influenced by the cosmetics industry, 

is visibly increasing and shaping the nutricosmetics 

offer. When sourcing ceramides, 

a close attention is to be paid on ingredients’ 

origin, quality and traceability to be 

able to answer the consumers’ expectations. 

Phytoceramides are plant-based ceramides, 

found naturally in plants and grains, 

answering the consumer requirements for 

clean-label, non-GMO, organic and vegan 

solutions. 

A solution adapted to the needs of 

modern consumers 

The strong science behind oral supplementation 

with phytoceramides opens the 

door for new opportunities in skin beauty. 

Ceramosides is a perfectly adapted solution 

for modern consumers that are looking 

for new ways to address anti-ageing with 

demonstrated efficacy and quick action. 

Ceramosides offers full body coverage 

with results that can be perceived by the 

consumers, as it acts rapidly on the visible 

layer of the skin. 

Ceramosides is a natural oil, suitable 

with soft gel capsules and other innovative 

galenics such as shots and beverages 

thanks to its low dose that makes it suitable 



with stable emulsions. A hydrosoluble powder, obtained from the oil, 

also makes it suitable for a wide range of applications other than 

tablets and capsules. It can be easily incorporated in trendy dosage 

forms such as drinks, gummies, powder sticks or chocolate bites. 

Ceramosides also helps manufacturers to address the growing 

need for clean label ingredients. Free from additives and preservatives, 

Ceramosides is “100 % made in France”, from wheat sourced 

and processed in France. It has been granted a GRAS (Generally 

Recognized As Safe) status by an external expert panel and is fully 

suitable for vegan formulations. It is also available as organic certified 

offering an ideal solution for clean beauty products and answering 

the growing demand for organic certified supplements. 

8 consumers in 10 satisfied 

by the improvement 

on their stress and sleep 

With the increasing demand for nutricosmetics and anti-ageing 

ingestible solutions, phytoceramides from wheat represent a natural 

and effective solution backed by strong science. With Ceramosides TM , 

Seppic intends to provide a powerful solution for innovative and 

attractive anti-ageing and moisturizing products. Scientific research 

will continue to demonstrate the potential of ceramides to promote 

healthy aging from within, enabling brands to develop appealing and 

tasty solutions to this fast-moving market. 

References 

1 

Jonca N. 2019. Ceramides metabolism and impaired epidermal barrier in cutaneous 

diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of 

v-O-acylceramides and its pathophysiological involvement in some forms of congenital 

ichthyoses. OCL 26: 17. 

2 

Bizot, V. et al. Improving Skin Hydration and Age-related Symptoms by Oral Administration 

of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study. 

Cosmetics 2017, 4, 37. 

3 

Ueda O, Hasegawa M, Kitamura S. Distribution in Skin of Ceramide after Oral Administration 

to Rats. Drug Metabolism and Pharmacokinetics. 2009;24(2):180- 

4 

https://www.mordorintelligence.com/industry-reports/nutricosmetics-market 


Lea Marchal, food engineer 

Active Ingredients Product Manager - 

Nutrition Activity 

SEPPIC - Air Liquide Healthcare Specialty 

Ingredients, France 

www.seppic.com 

STRESS 

MANAGEMENT 

UNIQUE 

& NATURAL 

CLINICALLY 

PROVEN 

REGULATORY 

APPROVED 

Lactium® is a brand of Ingredia 

www.lactium.com 


25


Photo © : Adobestock/RFBSIP 

Age-related macular degeneration: 

Micronutrients for prevention and therapy 

Philipp Gebhardt 

The so-called “yellow spot” is an area in the centre of the 

retina where the photoreceptor cells are particularly densely 

arranged. It is the area of sharpest vision. The yellow spot 

(Latin “Macula lutea”) owes its name to its coloration, which 

is caused by high concentrations of carotenoids that are 

stored here and form a natural sunscreen. With increasing 

age, there is an increased deposit of metabolic waste 

pro ducts in the area of the macula. Together with the incident 

light, these deposits catalyse the formation of free radicals, 

which damage the photoreceptor cells and result in 

degeneration of the macula. For the prevention and treatment 

of age-related macular degeneration, certain carotenoids 

can improve the protection of the eyes from sunlight. 

Together with radical scavenging micronutrients, they can 

counteract the increasing damage to the photoreceptor cells. 

The lens of the eye bundles the light entering through the pupil at the 

back of the eye in such a way that a sharp image can form on the 

retina, which is recorded by the light-sensitive outer segments of the 

photoreceptor cells. In each eye, around 6 million “cone cells” are 

responsible for colour vision and around 120 million “rod cells” for 

twilight vision. Conscious, sharp vision is focused on a small area in the 

Vitreous body 

Lens 

Light 

Pupil 

Cornea 

Macula 

Optic nerve 

Retina 

Fig. 1: The light entering the pupil reaches the retina through the cornea, 

lens and vitreous body. The macula is a narrowly defined area in the rear, 

central area of the retina, through which the visual axis runs and in whose 

centre the distribution of light-sensitive sensory cells is at its greatest 

density. 



centre of the retina. The macula lutea (Latin 

for “yellow spot”) located here is a place with 

a particularly high density of photoreceptor 

cells (Fig. 1). The macula owes its yellow 

colour to the antioxidant and UV light filtering 

pigments lutein and zeaxanthin, which are 

contained in 1.000-fold higher concentrations 

in this area, compared to blood levels. 

About 100,000 cone photoreceptors with 

their outer segments are arranged in an 

area with a diameter of about 3 mm. Due to 

the effect of the concentrated light, around 

10,000 outer segments have to be renewed 

every night, which can only take place by a 

particularly intensive metabolism. Over time, 

insoluble degradation products are increasingly 

deposited and accumulate in the 

retina. A prominent representative of these 

residues from proteins and fats is called lipofuscin. 

In conjunction with UV light, lipofuscin 

catalyses the formation of free radicals. 

These are reactive oxygen species that 

damage surrounding tissue. With a particularly 

powerful radical scavenging system, the 

eye can defend itself against oxidative stress. 

With increasing age, the capacity of the antioxidative 

mechanisms decreases significantly. 

Age-related macular degeneration 

Age-related macular degeneration (AMD) 

is a disease of the retina and the choroid 

behind it. It usually appears in the form 

of visual disturbances, which appear in a 

bending of straight lines and in image failures 

in areas of the field of vision. Due to 

the increased accumulation of lipofuscin in 

the retina, the function of the visual cells is 

increasingly impaired and they eventually 

die off. The patchy disappearance of larger 

and larger areas (“geographic atrophy”), in 

the advanced stage, is a common cause of severe vision loss in old 

age. AMD comes in two forms. The so-called dry form of the disease 

accounts for about 80 % of cases. In this form, the ability to see is 

increasingly impaired in the central field of vision. In the wet form 

of the disease, flat vascular membranes also form under the retina, 

which tend to bleed. This can quickly lead to reading blindness. Due 

to the demographic development, the number of people affected by 

AMD is increasing significantly. In industrialized countries, the disease 

is the main cause of blindness in people over 50, followed by glaucoma 

and diabetic retinopathy. In Germany, about 12 % of the population 

are affected by early stages of AMD. In contrast, about 0.2% 

suffer a late form of macular degeneration characterized by choroidal 

neovascularization (new blood vessel formation in the retina) with 

fibrosis and formation of scars (in wet AMD) or geographic atrophy 

(in dry AMD). (1) 

The role of mitochondria in AMD 

Mitochondria are cell organelles enclosed by a double membrane 

in which oxidative phosphorylation, i. e. energy production using 

oxygen, takes place. As the “power plants of the cells”, mitochondria 

are responsible for generating more than 90% of the energy of 

metabolism in the form of adenosine triphosphate (ATP). Anaerobic 

processes can only produce 2 moles of ATP per mole of glucose. 

Aerobic energy production via the respiratory chain located in the 

mitochondria can generate 36 moles of ATP from one mole of 

glucose. The mitochondria therefore enable energy production to be 

18 times more efficient. Electrons are transferred from complex I and 

complex II of the respiratory chain to coenzyme Q10, which transfers 

them to complex III and via cytochrome C to complex IV. The electrons 

are brought to a lower energy level and the released energy is 

used to pump protons through the membrane to build up an electrochemical 

gradient. At complex IV, the electrons are transferred to 

oxygen to form water while consuming protons. The excess protons 

between the inner and outer membrane are broken down at complex 

V in order to regenerate ATP from ADP and phosphorus with the 

energy gained (Fig. 2). 

Reactions with oxygen also produce relevant amounts of oxygen radicals 

in the mitochondria. By transferring electrons to oxygen, superoxide 

radicals (O 2 

-) are formed in a magnitude of about two percent of 

the oxygen converted. Antioxidants such as coenzyme Q10 and anti- 

H + 

H + 

H + 

H + 

e 

Cyt C 

Complex 

Q10 

Complex 

e Complex Komplex Complex 

I e e 

e III 

IV 

V 

Complex 

II 

NADH NAD+ 

O 2 2H 2 O 

Succinate Fumarate 

ADP+P ATP +H 

H + 

H + 

H + 

H + 2 O 

Fig. 2: The energy from our food is used via the respiratory chain to pump electrons across the inner mitochondrial membrane. At 

complex V, the proton gradient is broken down and the released energy is used to regenerate ATP, the cell's energy carrier. 


27


oxidant scavenging enzymes can normally neutralize the free radicals 

that are formed. If these protective mechanisms are impaired in their 

function or the amount of radicals formed exceeds the capacity of the 

antioxidative mechanisms, a dangerous state of crisis can develop, 

since damage to the respiratory chain complexes by free radicals 

further increases radical formation. 

In the case of AMD, there is an increased formation of free radicals 

primarily because a component of lipofuscin, the so-called A2E 

(N-retinylidene-N-retinylethanolamine) has an inhibitory effect on 

complex IV of the mitochondrial respiratory chain. A2E interrupts the 

flow of electrons via cytochrome C to complex IV. As a result, more 

electrons are transferred to oxygen at complex III and more superoxide 

radicals are formed, which damage proteins and membrane 

structures (Fig. 3). (2) 

In addition, coenzyme Q10 is a fat-soluble 

antioxidant that integrates into cellular 

and mitochondrial membrane structures 

and protects them from radical-induced 

damage. Coenzyme Q10 can regenerate 

other antioxidants such as vitamin C and 

vitamin E, which can also scavenge more 

free radicals. As a result, coenzyme Q10 

can protect the body's own structures from 

oxidative damage both directly and indirectly. 

Due to the increased oxidative stress, 

the retina has a relatively high concentration 

of coenzyme Q10. However, the levels 

decrease significantly with age (Fig. 4). Due 

to the decreasing coenzyme Q10 content, 

H + Superoxide radicals 

. H + 

O - 2 

. 

O - 2 

Complex 

Q10 e 

Q10 

Complex 

I e e 

e III 

Complex 

II 

NADH NAD+ 

Succinate Fumarate 

H + 

. 

O - H + 2 

Complex 

IV 

N 

A2E 

OH 

Fig. 3: A component of lipofuscin, A2E inhibits the transfer of electrons in the mitochondrial respiratory chain. As a result, more 

electrons are transferred to oxygen. As a result, more oxygen radicals are formed, which damage membrane structures and respiratory 

chain complexes. 

Apart from a directly harmful effect of the oxygen radicals, the reduced 

ATP formation also has serious consequences that promote the further 

progression of the disease. In the area of the macula, the effect of 

the concentrated light requires an intensive repair capacity, which is 

particularly dependent on the availability of energy in the form of ATP. 

Impaired respiratory chain function ultimately results in a decreased 

ability to repair photodamage, further deteriorating vision. 

The influence of micronutrients 

on the pathogenesis of AMD 

There is currently no way to treat AMD causally. However, promising 

studies have shown that the progression of the disease can be 

stopped or at least slowed down by micronutrients that support antioxidant, 

anti-inflammatory and mitochondrial function. It could even 

be shown that micronutrients such as coenzyme Q10, acetyl-L-carnitine, 

omega-3 fatty acids and lutein can significantly improve vision 

in people with AMD. 

Coenzyme Q10 

Coenzyme Q10 (ubiquinone) is a quinone with a side chain 

consisting of 10 isoprene-units that transfers electrons between 

respiratory chain complexes and can enhance energy production. 

the antioxidant capacity of the tissues 

decreases, while the load from oxygen radicals 

increases. The positive effect of coenzyme 

Q10 supplementation was confirmed 

in a clinical study in which 106 participants 

Coenzyme Q10-content (nmol/g dry weight) 

60 

50 

40 

30 

20 

10 

0 

≤ 10 Years 

Content retina 

Content choroid 

≥ 90 Years 

Fig. 4: The coenzyme Q10 content of the retina 

and the choroid lying under the retina decreases 

with increasing age. 



with AMD received either a dietary supplement 

with acetyl-L-carnitine, omega-3 fatty 

acids and coenzyme Q10 or a placebo. While 

the visual performance in the placebo group 

deteriorated significantly in the following 12 

months, the participants in the verum group 

showed a significant improvement in visual 

functions. (3) 

Acetyl-L-Carnitine 

Carnitine is formed from the amino acids 

lysine and methionine and plays an essential 

role in the transport of long-chain fatty 

acids into the mitochondria. In its acetylated 

form, carnitine can more easily cross cell 

membranes and act inside the cell. Acetyl- 

L-carnitine improves mitochondrial energy 

production and reduces lipofuscin deposition 

by promoting fat metabolism. In AMD, 

supplementation together with coenzyme 

Q10 and omega-3 fatty acids can significantly 

improve visual parameters and slow 

down disease progression. (3) 

Omega-3 fatty acids 

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are 

polyunsaturated fatty acids that belong to the group of omega-3 fatty 

acids and form structural components of cell membranes. In the 

eye, high concentrations of DHA are stored in the outer segments of 

the photoreceptor cells. Omega-3 fatty acids have a beneficial effect 

on membrane fluidity and the function of membrane-associated 

proteins. This makes the membranes of the blood cells more flexible. 

They can pass through the narrow capillaries of our blood vessels 

more easily and improve tissue oxygenation. In AMD, supplementation 

with omega-3 fatty acids can significantly improve antioxidant 

capacity. A clinical study with 172 participants was also able to show 

a positive influence on the optical density of the macular pigment and 

a significantly beneficial effect on blood lipid levels. (4) 

Lutein 

The carotenoids lutein and zeaxanthin are stored in high concentrations 

in the macula. They filter out large portions of the high-energy 

blue-violet light and serve as “natural sunglasses” that mitigate the 

harmful effects of the radiation. With a reduced carotenoid content 

in the macula, there is both an increased harmful effect of the lipofuscin 

deposits and increased exposure to light, which particularly 

Expert in health ingredients and innovative formulations 


contact@seanova.fr +33(0)2 98 50 41 60 

// 


29


affects blue-sensitive photoreceptor cells. 

With AMD, the perception of blue and 

violet is therefore the first to fail. The colour 

impression shifts towards grey to brown. It 

could be shown that low carotenoid concentrations 

in the macula are causally involved 

in the development of AMD and can predict 

corresponding eye damage with lead times 

of around 20 years. (5) The macular pigment 

lutein must be ingested with food because 

the body cannot synthesize it from other 

carotenoids such as β-carotene. The structurally 

related carotenoid zeaxanthin, on the 

other hand, can be synthesized from lutein 

if required. A recent review that evaluated 

data from more than 900 participants with 

AMD showed significant improvements in 

visual acuity and contrast sensitivity. Accordingly, 

supplementation of lutein increases 

the pigment content of the macula in a dosedependent 

manner. (6) 

Improving bioavailability through 

phospholipids 

Coenzyme Q10 and lutein are not soluble in 

water and only have a limited solubility in fats. 

The active ingredients tend to agglomerate 

in the gastrointestinal tract when supplemented 

in powder capsule or tablet form. 

As a result, only molecules on the surface 

of the agglomerates can be absorbed by the 

enterocytes of the small intestine, while the 

majority pass through the body unchanged. 

However, a significant improvement in bioavailability 

can be achieved by forming emulsions 

with natural phospholipids (lecithin), in 

which the active ingredients are present in 

small droplets coated with lecithin (Fig. 5). 

Lecithin is also a natural component of bile 

that facilitates the absorption of dietary fats 

and fat-soluble nutrients. A crossover study 

was able to show that the bioavailability of 

coenzyme Q10 can be improved by a factor 

of five with an appropriate formulation. (7) 


Philipp Gebhardt 

65779 Kelkheim, Germany 

p.gebhardt@mitotherapie.de 

Conclusion 

7 

2 

1 

Fig. 5: Improvement of the bioavailability of 

coenzyme Q10 by formulation with lecithin: Coenzyme 

Q10 is packaged in ultra-small droplets 

with natural phospholipids [1]. The absorption 

of the coenzyme begins in the mouth via the oral 

mucosa [2]. The lecithin shell protects the active 

ingredients from the harsh environment of the 

stomach [3]. Lecithin is a natural component of 

bile that facilitates the digestion of dietary fats 

and fat-soluble nutrients [4]. The prepackaged 

coenzyme Q10 can be absorbed much better 

by the enterocytes of the small intestine [5]. In 

the enterocytes, fat-soluble nutrients are packed 

into chylomicrons or lipoproteins with the help 

of phospholipids [6]. For systemic distribution, 

the coenzyme Q10-containing chylomicrons are 

released into the lymph and the coenzyme Q10- 

containing lipoproteins into the blood [7]. 

The development of age-related macular 

degeneration is promoted by a low carotenoid 

content in the macula. The carotenoid lutein 

can improve the eye’s natural sun protection 

and thus reduce the harmful effects of light 

and the light-induced formation of oxygen 

radicals. Antioxidants such as coenzyme 

Q10 can increase the neutralization capacity 

for oxygen radicals and help to protect the 

eyes. In addition to its antioxidant effect, 

coenzyme Q10 is characterized by the fact 

that it improves the function of the respiratory 

chain and contributes to energy production. 

In addition to a low intake of lutein with 

food, smoking and high blood pressure are 

considered risk factors for AMD. (8) In addition, 

increased concentrations of the toxic 

metabolic intermediate homocysteine and 

reduced vitamin B12 levels have also been 

identified as risk factors. (9) 

3 

Enterozyte 

6 

5 

4 

References 

(1) Brandl, C., Stark, K. J., Wintergerst, M., Heinemann, 

M., Heid, I. M., & Finger, R. P. (2016). Epidemiologie der 

altersbedingten Makuladegeneration. Der Ophthalmologe, 

113(9), 735-745. 

(2) Suter, M., Remé, C., Grimm, C., Wenzel, A., Jättela, M., 

Esser, P., ... & Richter, C. (2000). Age-related macular 

degeneration the lipofuscin componentn-retinyl-n-retinylidene 

ethanolamine detaches proapoptotic proteins 

from mitochondria and induces apoptosis in mammalian 

retinal pigment epithelial cells. Journal of Biological 

Chemistry, 275(50), 39625-39630. 

(3) Feher, J., Kovacs, B., Kovacs, I., Schveoller, M., Papale, 

A., & Gabrieli, C. B. (2005). Improvement of visual functions 

and fundus alterations in early age-related macular 

degeneration treated with a combination of acetyl-L-carnitine, 

n-3 fatty acids, and coenzyme Q10. Ophthalmologica, 

219(3), 154-166. 

(4) Arnold, C., Winter, L., Fröhlich, K., Jentsch, S., 

Daw czynski, J., Jahreis, G., & Böhm, V. (2013). Macular 

xanthophylls and ω-3 long-chain polyunsaturated fatty 

acids in age-related macular degeneration: a randomized 

trial. JAMA ophthalmology, 131(5), 564-572. 

(5) Arunkumar, R., Calvo, C. M., Conrady, C. D., & Bernstein, 

P. S. (2018). What do we know about the macular 

pigment in AMD: the past, the present, and the future. 

Eye, 32(5), 992-1004. 

(6) Feng, L., Nie, K., Jiang, H., & Fan, W. (2019). Effects of 

lutein supplementation in age-related macular degeneration. 

PloS one, 14(12). 

(7) Wajda, R., Zirkel, J., & Schaffer, T. (2007). Increase of 

bioavailability of coenzyme Q10 and vitamin E. Journal of 

medicinal food, 10(4), 731-734. 

(8) Hyman, L., & Neborsky, R. (2002). Risk factors for agerelated 

macular degeneration: an update. Current opinion 

in ophthalmology, 13(3), 171-175. 

(9) Rochtchina, E., Wang, J. J., Flood, V. M., & Mitchell, P. 

(2007). Elevated serum homocysteine, low serum vitamin 

B12, folate, and age-related macular degeneration: the 

Blue Mountains Eye Study. American journal of ophthalmology, 

143(2), 344-346. 


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Apart from the macronutrients fats, carbohydrates and 

proteins an adequate supply of minerals is essential for the 

health and performance of athletes. Calcium, Potassium and 

Magnesium are among the best-known minerals, but also 

trace elements like Iron and Zinc are of high importance – 

especially for athletes. These minerals and trace elements 

ensure optimal functioning of muscles and nerves, besides 

they are involved in the formation of bones and in the regulation 

of blood pressure. 1 

Athletes have an increased need for minerals 

and trace elements due to a higher demand 

on the metabolism and the loss through 

perspiration. The most common deficient 

minerals are Sodium, Calcium, Magnesium, 

Potassium as well as Iron, Zinc. 2 Depending 

on the type of sport, the intensity and extent 

of exercise, and individual factors (e. g. nutritional 

behaviour, sweat rate and composi- 

Element 

Nutrient 

Reference 

Values 4 (NRV) 

Mineral Concentration 

in Sweat with approx. 60 min 

of physical exercise 5, 6 

Functions within the Body 

Calcium 800 mg 11–36 mg/l Muscle function – regulation of contraction, 

energy metabolism 

Magnesium 375 mg 0.84–2.36 mg/l Maintenance of bones, muscle function – counterpart 

to Calcium, protein synthesis, energy 

metabolism, decrease of tiredness/fatigue 

Potassium 2000 mg 167–236 mg/l Blood pressure, muscle function 

Iron 14 mg 0.56–1.12 mg/l Formation of red blood cells/haemoglobin, 

oxygen transport, reduction of tiredness/fatigue 

Zinc 10 mg 0.92–1.23 mg/l Cell protection from oxidative stress, immune 

system, metabolism of macronutrients, 

protein synthesis 



tion), athletes may be at increased risk of 

suboptimal supply of some micronutrients. 3 

In addition to the daily diet, dietary supplements 

can help to ensure the supply of all 

important minerals and trace elements. 

The detection of mineral deficiency symptoms 

is still rather difficult. 1 Usually such 

symptoms are unspecific, e. g. general indisposition 

or fatigue. As minerals are fixed with 

liquid compartments, every loss of water 

is also a loss of minerals. 1 Especially for 

athletes the replenishment of mineral losses 

is of special importance. 

Nutrition is an important tool in terms of 

performance optimisation and regeneration. 

There is no perfect formula to satisfy 

every athlete’s personal nutritional needs, as 

every sport has its own specific strain on the 

human body and every athlete is physically 

different. 2 

Sports nutrition was a niche sector in the past 

and has developed into a growth market. At 

the same time, customers became more 

diverse. It formerly used to be elite athletes 

who would focus nutrition, whereas now it 

can be the office worker commuting by bike, 

who has an interest in nutrition in order to 

support a healthy lifestyle. 7 

Power sports 

The category “power sports” can be divided into three main areas: 

maximum strength, quickness and strength endurance. The goal of 

power sports is to set free the highest amount of muscular power 

possible over a usually short duration. 1 

In addition to the macronutrients, mineral salts are a key factor for 

successful competition. Training sessions are not as long as in endurance 

sport, a remineralisation during training is not required. 8 Nevertheless, 

minerals as important micronutrients ensure that the muscle 

can be used up to its full potential, supporting muscle contraction, 

energy metabolism as well as the nervous system. 9 

Popular sports 

The category “popular sports” summarises physically active people, 

exercising to keep a certain level of fitness or as a hobby. The category 

is nondependent on the type of exercise. As the strains are not 

as demanding as those of competing athletes, a coordinated nutrition 

is usually not of high importance. Though, nutritional considerations 

are not irrelevant for them, as they support the build-up of power and 

stamina. 

As popular sports are physically demanding as well, sweat is lost 

during performance. Compared to competing athletes, “untrained 

people” have a different composition of the sweat, due to the fact, that 

the organism is not as used to intensive strains. The sweat contains 

more minerals as opposed to trained athletes, who are able to recover 

some minerals with their sweat glands and whose sweat contains less 

minerals in general. 1 

Endurance athletes 

The main goal of an endurance athlete is to 

hold the highest possible power for a specific 

period. The need of macronutrients, especially 

carbohydrates, is high due to of the 

increased amounts of energy, these athletes 

transform over a long period. 

Besides macronutrients, hydration is an 

important factor, endurance athletes should 

focus on. As muscle activity produces heat, 

the body uses the endothermic effect of the 

evaporation of the sweat in order to prevent 

the danger of overheating. Perspiration leads 

to an increased need for water and minerals, 

as sweat contains about 2–3 g of mineral 

salts per litre. 1 However, after long lasting 

exercises with intensive losses of sweat and 

thus minerals, it is generally recommended 

to replenish the lost minerals. 8 

Photo © : iStock/GlobalStock 


33


The function of minerals for athletes 

Calcium 

Calcium is a bivalent metal and corresponds to 1.5 % of the human 

bodyweight. 1 About 99 % of the amount is bound in bones and teeth. 

Together with phosphate, it is of high importance for their stability. 10 

The body uses the Calcium stores in the bones as a reservoir. Additionally, 

Calcium plays a key role in regulating various processes in 

neural transmission, as well as in the haemostasis, the stabilisation 

of cell membranes and the regulation of metabolism-processes. 9 

Furthermore, Calcium is responsible for all muscle contractions via 

the transmission of stimuli from the neural system to the muscle cell. 

A deficiency has an impact on the maximum tension capacity during 

strength training. Symptoms like a rising excitability of the muscle or 

cramps can be the consequence. 10 

Magnesium 

Since Magnesium is an activator of all reactions involving ATP 

(Adenosine Triphosphate), it is of high importance to physical 

performance. 1 The body of a 70 kg adult, contains 20–28 grams of 

Magnesium. In combination with Calcium, about 60 % of Magnesium 

is stored in the bones as hydroxyapatite. The remaining Magnesium 

can be found to 35 % in intracellular and to 5 % in extracellular 

solution. 10 

The Magnesium is used for growth and stabilization of bones. Additional 

functions are to be an essential cofactor of more than 300 

enzymes in the metabolism, support of muscle contraction, synthesis 

of proteins and nucleic acids as well as the release of hormones 

and neurotransmitters. Magnesium is a catalyzer for ATP-dependant 

enzyme systems and therefore part of the energy-metabo lism. 

Together with Potassium, Calcium and Sodium it is necessary for 

the transition of chemical into mechanical energy in the muscles. 

Magnesium is the counterpart of Calcium. While Calcium is responsible 

for passing on the stimulus to the muscle, Magnesium closes 

the ion channel again and prevents the continuous tensioning of the 

muscle. 1 

A deficiency (hypomagnesemia) hampers the appropriate relaxation 

mechanism of Magnesium and can cause spasms and tensions 

in muscles. Other signs and symptoms of hypomagnesemia 

include anything from mild tremors and generalized weakness to 

vascular spasms of heart and blood vessels and cardiac arrhythmia. 

Hypomagnesemia can be innate or occur due to reduced resorption, 

increased excretion or medication but in the most common 

cases due to insufficient supply. 11 In Germany alone, 26 % of men 

and 29 % of women do not reach the daily amount of magnesium 

recommended by the D-A-CH reference values. 11 In addition to a 

diet low in Magnesium, sporting activity is also a factor that can lead 

to an undersupply. During intensive sporting activity, a high proportion 

of Magnesium is lost, especially through sweat. 2 This makes a 

balanced Magnesium intake vital, especially for athletes. 

Potassium 

More than 90 % of Potassium in the human 

organism is located in the intracellular 

medium. 10 As the most important intracellular 

cation, Potassium is responsible for 

the maintenance of the intracellular osmotic 

pressure and it is involved in many metabolic 

processes as well. 12 

Symptoms of a Potassium deficiency are 

diverse. They vary from apathy, to decreased 

neuromuscular stimulation, cramps, gastrointestinal 

complaints, tachycardia, kidney 

damage, decreased glucose tolerance and 

1, 8, 12, 13, 14 

cardiac dysfunctions. 

Athletes can be at risk of Potassium deficiency 

for multiple reasons. For once Potassium 

is closely bound to the glycogen 

metabolism. During the metabolisation of 

glycogen, Potassium is set free, which is 

in turn needed for the resynthesis. 1 Moreover, 

Potassium is lost through increased 

sweating during long strains. 10,12 Especially 

endurance athletes prone to heavy perspiration 

should therefore be advised to consume 

additional Potassium. 15 

Iron 

Iron is the most important trace element in 

the human organism, with body stores of 

3–5 g. 10 Nutritional Iron is available as haem 

Iron and ionised Iron, respectively Fe (II) and 

Fe (III). 16 

Iron is a central component of red blood 

cells. Without Iron, the blood could not transport 

oxygen and supply the muscles. In the 

muscle, it is present as the central component 

of myoglobin in order to transport 

oxygen into the heart and skeletal muscle 

tissue. It acts as an antioxidant and is an 

important component of the electron transport 

chain for the production of ATP. 17 

Iron deficiency is associated with altered 

metabolic processes. Physical manifestations 

of an iron deficiency are e. g. anaemia, 

fatigue and weakness, pale skin, brittle 

nails. In the field of sports nutrition, Iron is 

regarded as one of the most critical micronutrients 

18 and counterintuitively iron deficiency 

is one of the most commonly diag- 



nosed mineral deficiencies in sports medicine. 

19 The high incidence of Iron depletion 

among athletes is usually linked to an inadequate 

energy intake. Factors affecting the 

Iron status are e. g. vegetarian diet, periods 

of rapid growth, training at high altitudes, 

increased Iron losses in sweat, and other 

body fluids. 19 

Iron is involved in the transport and metabolism 

of oxygen for aerobic energy production 

during endurance exercise. Athletes 

with suboptimal Iron status may experience 

reduced exercise capacity and impaired 

sports performance. 20 Once an iron deficiency 

has developed, the recovering can 

take months. 21 The Iron supplementation of 

iron-deficient athletes improves blood biochemical 

measures and iron status on the 

one hand, on the other hand it also increases 

work capacity as evidenced by increasing 

oxygen uptake, reduces the heart rate and 

decreases the lactate concentration during 

exercise. 18 

utes to the protein synthesis and is involved 

in the adaptation process of training stimuli, 

process of growth, wound healing and 

general functions of the immune system. 19 

However, a relatively low Zinc status has 

been observed in many athletes, which is 

caused by an insufficient intake with food 

and increased losses through urine and 

sweat. Continuously high exercise volumes 

and additional strains induced through 

the participation in competitions lead to 

increased Zinc losses. As a result, active 

athletes generally have higher Zinc requirements. 

Especially at risk are high endurance 

athletes, athletes using a hypocaloric 

diet in order to compete in certain weight 

classes and vegetarian or vegan athletes. If 

an increased Zinc intake cannot be achieved 

through an adjusted diet, supplementation is 

1, 10, 19, 22 

a sensible remedy. 

How to find the best mineral salt 

The choice to the anionic part of a mineral 

salt is of particular importance. Beside 

physi cal and chemical properties like solubility, 

pH-value and taste, anions have also 

an important influence on the bioavailability 

Bioactive Collagen Peptides stimulate 

the body's own collagen metabolism 

Zinc 

Zinc is a trace element with a relatively 

small storage capacity in the human body, 

compared to Iron. Hence, large quantities of 

Zinc cannot be mobilised if higher requirements 

arise. Therefore, a constant intake of 

Zinc through food or food supplements is 

indispensable. 10 

Zinc fulfils catalytic, structural and regulatory 

functions in the organism and is 

involved in more than 300 metalloenzymes, 

as a co-factor or as an integral part. As Zincdependent 

enzymes are present in all metabolic 

areas. It is also involved in almost all 

life processes and thus also in antioxidative 

mechanisms. Moreover, Zinc itself has an 

antioxidative effect, since it is able to bind 

to various molecules and to protect them 

against oxidative damage. A Zinc deficiency 

manifests in a reduced immunological 

defence, dermatitis, hair loss, and delayed 

wound healing. 10 

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and the compatibility. Organic acids promote the absorption of certain cations, like Magnesium, 

Calcium, and Iron. Citrate, malate and fumarate are part of the citric acid cycle within 

the human metabolic pathway and are therefore easy to digest. Fully reacted mineral salts 

from amino acids like bisglycinates are known for an excellent bioavailability and are well 

tolerated. 

Mineral Salts of Dr. Paul Lohmann ® are especially designed for the use in food supplements. 

They fulfill the purity parameters for ready to use food supplements already in the raw material 

state. These quality parameters were decreed by the European Commission to ensure the 

constantly high quality and purity of food supplements. Different techniques of particle size 

engineering like micronization, granulation or microencapsulation is a strength of Dr. Paul 

Lohmann ® . Tailor-made product developments and product adaptions are carried out in close 

collaboration with the customers. 

Best performer in sports nutrition 

Mineral Salt Soluble Insoluble 

Calcium 

Magnesium 

Iron 

Zinc 

Potassium 

Dr. Paul Lohmann GmbH & Co. KGaA 

Hauptstr. 2 

31860 Emmerthal/Germany 

sales@lohmann4minerals.com 

www.lohmann4minerals.com 

Calcium Bisglycinate 

Calcium Lactate PLUS 

Magnesium Bisglycinate 

Magnesium Citrate 

Magnesium Citrate Malate* 

Magnesium Gluconate 

Ferrous Bisglycinate 

Ferrous Gluconate 

Ferrous Sulfate 

Zinc Bisglycinate 

Zinc Ascorbate* 

Potassium Magnesium Citrate 

Potassium Citrate 

*Only permitted for food supplements in Europe 


Calcium Citrate 

Calcium Citrate Malate 

Magnesium Carbonate 

Magnesium Lactate 

Magnesium Malate* 

Magnesium Phosphate 

Ferrous Fumarate 

Ferric Pyrophosphate 

Zinc Citrate 

Zinc Malate* 

Zinc Sulfate 

- 

References 

1 

Baron, D., & Berg, A. (2005). Optimale Ernährung des 

Sportlers. Stuttgart: S. Hirzel Verlag. 

2 

Neumann, G. (2016). Ernährung im Sport. Aachen: 

Meyer & Meyer Verlag. 

3 

Sawka Mn, Burke Lm, Eichner Er, Maughan Rj, Montain Sj, 

Stachenfeld Ns. American College of Sports Medicine position 

stand. Exercise and fluid replacement. Med Sci Sports 

Exerc. 2007; 39: 377-390. 

4 

Regulation (EU) No 1169/2011 of the European Parliament 

and of the Council of 25 October 2011 on the provision of 

food information to consumers 

5 

Montain Sj, Cheuvront Sn, Lukaski Hc. Sweat mineralelement 

responses during 7 h of exercise-heat stress. Int 

J Sport Nutr Exerc Metab. 2007; 17: 574-582. doi:10.1123/ 

ijsnem.17.6.574 

6 

Chinevere Td, Kenefick Rw, Cheuvront Sn, Lukaski Hc, 

Sawka Mn. Effect of heat acclimation on sweat minerals. 

Med Sci Sports Exerc. 2008; 40: 886-891. doi:10.1249/ 

MSS.0b013e3181641c04 

7 

Carey, A. (2017). A healthy market - the rise and rise of 

sports nutrition. International Journal of Nutraceuticals, 

Functional Foods and Health Ingredients, vol. 28, issue 6, 

S. 6-7. 

8 

Vollmer, G., & al., e. (1995). Lebensmittelführer 2. 

Stuttgart: Georg Thieme Verlag. 

9 

Biesalski, H. K., & ad., e. (2002). Vitamine, Spurenelemente 

und Mineralstoffe. Stuttgart: Georg Thieme Verlag. 

10 

Hahn, A., & Schuchardt, J. (2011). Minerals - Metabolism, 

functions, Requirement. Hamburg: B. Behr's Verlag. 

11 

https://www.mri.bund.de/fileadmin/MRI/Institute/EV/ 

NVSII_Abschlussbericht_Teil_2.pdf, 22.03.2022 

12 

Scholz, H. (1996). Mineralstoffe + Spurenelemente. 

Stuttgart: Georg Thieme Verlag. 

13 

Friesenwinkel, H. (2005). Mineralstoffe. München: 

Knaur Ratgeber Verlage. 

14 

Zimmermann, M. (2003). Mikronährstoffe in der Medizin, 

3. Aufl. Stuttgart: Karl F. Haug Verlag. 

15 

Holmes, N., Bates, G., Zhao, Y., Sherriff, J., & Miller, V. 

(2016). The Effect of Exercise Intensity on Sweat Rate and 

Sweat Sodium and Potassium Losses in Trained Endurance 

Athletes. Annal of Sports Medicine and Research, vol. 3, 

issue 2, S. 1-4. 

16 

Schümann, K., & Weiss, G. (2002). Eisen. In H. Biesalski, 

J. Köhrle, & K. Schümann, Vitamine, Spurenelemente und 

Mineralstoffe - Prävention und Therapie mit Mikronährstoffen 

(S. 137-147). Stuttgart: Georg Thieme Verlag. 

17 

Suedekum, N., & Dimeff, R. (2005). Iron and the athlete. 

Current Sports Medicine Reports, vol. 4, issue 4, S. 

199-202. 

18 

Academy of Nutrition and Dietetics, A. o., Canada, D. o., 

& Medicine, A. C. (2016). Nutrition and Athletic Performance. 

Medicine & Science in Sports & Exercise, vol. 48, 

issue 3, S. 543-568. 

19 

Platen, P. (2002). Mikronährstoffe in der Sportmedizin. In 

K. Biesalski, J. Köhrle, & K. Schümann, Vitamine, Spurenelemente 

und Mineralstoffe - Prävention und Therapie mit 

Mikronährstoffen (S. 326-342). Stuttgart: Georg Thieme 

Verlag. 

20 

Koehler, K., Braun, H., Achtzehn, S., Hildebrand, U., 

Predel, H.-G., Mester, J., & Schänzer, W. (2012). Iron status 

in elite young athletes; gender-dependent influences of 

diet and exercise. European Journal of Applied Physiology, 

vol. 112, issue 2, S. 513-523. 

21 

Deakin, V. (2006). Iron depletion in athletes. In L. Burke, 

& V. Deakin, Clinical sports nutrition 3 rd ed. (S. Ch. 10 1-9). 

Sydney; New York: McGraw-Hill. 

22 

Fuhrman, J., & Deana, M. (2010). Fueling the Vegetarian 

(Vegan) Athlete. Current Sports Medicine Reports, vol. 9, 

issue 4, S. 233-241. 



Photo © : Capsularis/Unsplash 

A “new generation” of liposomes 

Although liposomes are on the rise, the 

products on the market often present 

problems of stability, traceability 

and organoleptic quality. Drawing on 

their expertise in microencapsulation, 

Capsularis has developed a unique 

liposomal process that places quality 

and naturality at the heart of the manufacturing 

process, in order offer to their 

customers premium liposomes 100 % 

Made in France. 

Capsularis offers vitamin C liposomes under 

the L-VITAL C ® brand. Is it just an additional 

offer from a company that made the vectorization 

of active ingredients its specialty? 

Not exactly: the technology used provides 

surprising solutions on the organoleptic level 

which renew the application of liposomes. 

Natural health supplements contain many 

active ingredients, such as vitamins, trace 

elements, antioxidants, etc. Digestion can 

degrade these active ingredients, or they can be poorly absorbed by 

the body. Their effectiveness can therefore be reduced. In order to 

improve the assimilation of vitamin C, Capsularis offers you its innovation, 

a microencapsulated vitamin C, in liposomal form: L-VITAL C ® . 

“When we started to develop a drinkable solution incorporating 

our liposomes, we were pleasantly surprised by its very pleasant 

taste and its remarkable stability”, reveals Stéphane Lozachmeur, 

founder and manager of Capsularis. “This innovation in the field of 

liposomes will allow us to bring innovation to our customers”. Innovation 

is anchored in the DNA of the company founded in 2008 and 

which relies in particular on a microencapsulation process developed 

in-house. The company, which has nearly twenty people, has 

its own R&D department which is equipped with a pilot lab to validates 

the scale-up. 

To develop its liposomes, the Capsularis R&D team focused on technologies 

for producing lipid vectors used in the pharmaceutical 

industry. The company invested in a production unit, which makes it 

possible to produce liposomes smaller than 200 nm. Another advantage 

of this new production equipment: the technology makes it 

possible to produce at low temperatures, which contributes to the 

preservation of active ingredients. 


37


What is a liposome? 

The word liposome, also called “lipid body”, comes from the Greek 

lipos, which means fat, and soma, the body. The discovery of 

liposomes dates back to the 1960s, during work carried out by Alec 

Bangham in Cambridge 1 . Liposomes were initially developed as a 

model of biological membranes, through their ability to imitate cell 

membranes. They have long been studied as vectors of active principles 

2 . 

The liposome is a lipid vesicle which carries an active ingredient. 

Photo © : Capsularis/Her-bak Médias 

The structure of the liposome is similar to the cell membranes of 

our body. 


Liposomes are made up of phospholipids, fatty substances present in 

our diet. They are found for example in cereals, nuts, eggs, sunflower. 

A phospholipid is composed of a hydrophilic head and hydrophobic 

tails. 

Thanks to its small size and this biomimicry, the liposome fuses with 

cell membranes. The active ingredient crosses the intestinal barrier 

more easily thanks to a mechanism called endocytosis. The active 

ingredient is released directly into the body, its bioavailability is thus 

improved. 

Thanks to their small size and to the phospholipids that make up 

their membrane, liposomes can be absorbed intact by certain cell 

types in the intestine. Therefore, vitamin C in liposomal form will 

partly bypass the classic absorption pathways which are saturable 

and will be more bioavailable than its non-liposomal counterpart. 3 

Studies have also shown that liposomal vitamin C is almost twice 

as bioavailable in the blood, compared to conventional vitamin C. 4-5 

The bioavailability of the active ingredient contained in the liposome 

is thus improved. 

Liposomes allow: 

– A protection of active ingredients from acid attacks in the stomach 

– An Improved bioavailability 

“We decided to develop our own liposomal formulations to offer on 

one hand a product Made in France and on the other hand because 

we believed that our expertise in microencapsulation would bring a 

differentiating element to the market.” 


Phospholipids are naturally organized into bilayers, then into 

liposomes in which an active ingredient can be encapsulated. 

Major breakthrough: Capsularis offers liposomes in a stable liquid 

form. There is a plethora of liposomes in powder form on the market, 

but liposomes need water to live/exist. Without it, their structure 

becomes unstable and breaks down: liposomes become unable to 

hold active ingredients in their heart. 



Essential Vitamin C 

Ascorbic acid, isolated in 1931 and synthesized 

in 1933 by two Nobel Prize winners in 

chemistry, is one of the vitamins described 

as essential for the optimal functioning of 

the human body. However, ascorbic acid 

can cause hyperacidity in the body. A more 

interesting choice to avoid this hyperacidity 

is vitamin C in the form of sodium ascorbate, 

which is none other than the sodium 

salt of L-ascorbic acid. Since the body is 

unable to synthesize vitamin C, we must 

find it in our diet. 

Vitamin C health benefits are numerous, and 

the most famous one is its antioxidant power. 

It is also an enzymatic cofactor essential to 

many biochemical reactions in the body. 

Proven health benefits: 

– Helps reduce fatigue 

– Strong antioxidant power to neutralize 

excess free radicals, essential for cell 

protection. It protects cells from oxidative 

stress and premature cell aging. 

– Contributes to the normal formation of 

collagen to ensure the normal function of 

the skin, teeth, gums, bones, cartilages 

and blood vessels. 

– Contributes to the proper functioning of 

the immune system (during and after 

intense physical exercise) and of the 

nervous system 

– Contributes to normal psychological 

functions 

– Contributes to normal energy metabolism 

and increases iron absorption. 

– Contributes to the regeneration of the 

reduced form of vitamin E 

L-VITAL C benefits 

– Liquid form: optimal efficiency/high 

assimilation 

– Absence of acidity (gastric), excellent 

digestive tolerance 

– Superior organoleptic qualities 

– Stability of liposomes over time 

– Traceability and quality of raw materials 

– Liposome size control 

– GMO-free, dye-free manufacturing 

– Suitable for the vegan diet 

– Produced in France, Brittany 

References 

1 

Meybeck A., Les liposomes en cosmétique, l’actualité chimique, 2008, 323-324, p.60. 

2 

He et al. Adapting liposomes for oral drug delivery. Acta Pharmaceutica Sinica B, 9(1), 

2019, 36-48. 

3 

He et al. Adapting liposomes for oral drug delivery. Acta Pharmaceutica Sinica B, 9(1), 

2019, 36-48 

4 

Hickey S, Roberts HJ, Miller NJ. Pharmacokinetics of oral vitamin C. J Nutr Environ Med. 

2008, 17(3):169–177. 

5 

Gopi et al. Evaluation and Clinical Comparison Studies on Liposomal and Non-Liposomal 

Ascorbic Acid (Vitamin C) and their Enhanced Bioavailability. Journal of Liposome 

Research, 2020, 1–35. 

WATER SOLUBLE GUAR BEAN 

FIBER WITH UNIQUE 

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of foods and beverages 

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Stéphane LOZACHMEUR 

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SEANOVA 

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VISIT US AT 

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TAIYO GmbH 

Hagener Str. 20, D-58285 Gevelsberg 

Tel. +49 2332 96788-0 

info@taiyogmbh.com · www.taiyogmbh.com 


39


Photo © : AdobeStock/fabiomax 

Natural solutions in baked goods. From early 

civilizations to modern innovation! 

A few years ago, charred remains of a flatbread baked 

14,000 years old, was found in the Jordanian desert. This 

fact could attest bread is the most compelling evidence of 

humans moving from hunter-gatherer societies to agricultural-based 

societies. Baking is probably one of the most 

ancient processes ever created by human kind. Wheat was 

already cultivated by the first civilizations in human history. 

They learned that wheat kernels could be grinded and transformed 

into flour, and by adding water to it and baking it, 

bread would be obtained. 

Nowadays, in modern and western societies, baked cereal pro ducts 

are one of the most consumed goods, and also one of the main 

sources of energy in human nutrition. This high and increasing 

demand of baked goods, is driving the manufacturers of the food 

industry to keep innovating and developing new formulations that can 

meet the quality requirements that the global population demands, in 

terms of safety, health and sustainability. 

To produce basic products such as bread, biscuits, cakes and pastry, 

the baking industry uses a wide range of natural raw materials. The 

essential ingredients for all baked products are flour, water and salt. 

In addition, for bread products, yeast, fats and minor ingredients can 

be included in the recipe. 

Therefore, when a new formula of a baked 

product is designed, the impact of new 

ingredients on the chemical transformations 

occurring during the production chain has 

to be determined. During preparation and 

baking of cereal products, many complex 

phenomena occur in the dough, leading to 

textural, physicochemical and organoleptic 

changes. Among the most important, we can 

cite volume expansion, starch gelatinisation, 

protein denaturation, fat melting, browning 

and formation of flavour compounds. 

Also, changing ingredients may have an 

impact on the main reactions occurring 

during the baking process, such as the 

Maillard reaction, caramelisation and lipid 

oxidation. The Maillard reaction occurs 

between the carbonyl groups of reducing 

sugars and the free amine functions of 

amino acids, peptides and proteins. Caramelisation 

depends on direct degradation 

of sugars. Lipid oxidation is a radical chain 

reaction, which can be decomposed into 



three phases (initiation with formation of 

free radicals, propagation and finally termination 

with formation of non-radical products). 

Whereas the Maillard reaction and 

caramelisation need high activation energy 

and thus mainly occur during thermal treatments, 

lipid oxidation requires low energy 

along with oxygen. 

Fats impart taste and texture to the product 

but because they susceptible to oxidation 

leading to the development of rancidity and 

off-flavour through the autooxidation or lipid 

oxidation reactions, additives, such as antioxidants 

are also added to the mixture. 

Antioxidants have become an indispensable 

group of food additives mainly because 

of their unique properties of enhancing 

the shelf life of food products without any 

damage to sensory or nutritional qualities. 

Concerns about the safety of synthetic antioxidants 

have given rise to a large body of 

research on natural sources of antioxidants. 

Natural antioxidants allow food processors 

to produce stable products with ‘‘clean’’ 

labels of all-natural ingredients. They bring 

less rigorous burden-of-safety proof than 

that required for synthetic products. In addition 

to their antioxidant activity, some natural 

antioxidants, such as vitamins, minerals, 

and enzymes, are also regarded as nutrients 

due to their bioactivity. 

Tocopherols and tocotrienols, collectively 

known as tocols, are monophenolic and lipophilic 

compounds that are widely distributed in plant tissues. The 

main commercial source of natural tocopherols is the soybean oil. 

Tocotrienols, less common than tocopherols, are present in palm oil, 

rice bran oil, as well ascereals and legumes. Tocopherols and tocotrienols 

are classified into alpha, beta, gamma, delta, depending on 

their chemical structures. These eight molecules are part of the group 

known as vitamin E. 

Tocopherols and tocotrienols are primary antioxidants, which act by 

terminating the free-radical chain reaction by donating hydrogen or 

electrons to free radicals and converting them to more stable products. 

Secondary antioxidants, such as ascorbic acid, citric acid, lecithin 

or flavonoids can be also added to the products. Secondary antioxidants 

can be broadly classified as oxygen scavengers and chelators. 

They have a synergic effect, together with tocopherols, as they 

act as hydrogen donors to the tocopheryl radical, thereby regenerating 

the primary antioxidant. Hence tocopherols can be used at 

lower levels if a synergist is incorporated simultaneously in the food 

product. 

In order to protect the baked goods from oxidation, antioxidants can 

be applied either to the final product, or directly to the oil previous 

to the mixing of ingredients. To measure the efficacy of tocopherolbased 

antioxidants, accelerated oxidation tests have been performed. 

In the first experiment, the Rancimat test was used. It is a simple, 

quick an efficient way to screen the effectiveness of antioxidants 

used in fats and oils. The method is an accelerated oxidation test in 

which the oil or fat to be tested is run at elevated temperatures whilst 

exposing the sample to air, accelerating the oxidation process of the 

oil. Soybean oil, one of the mayor oils in the baking industry, was 

mixed with different tocopherol-based natural antioxidants. 

Tocobiol ® is a natural antioxidant made from the distillation of a single 

raw ingredient, whole non-GMO soybean oil. It naturally contains 

mixed tocopherols, plant sterols, squalene and monoglycerides 

which provide its unique antioxidant and dispersibility properties.


It can be concluded that the use of tocopherols and its blends with 

other secondary natural antioxidants is a very effective method for 

protecting the fats and oils present in baking goods towards autoxidation 

and avoid rancidity in the final product. 

As it can be seen in Table 1, the addition of synergic antioxidants, 

such as the flavonoids present in green tea extract, ascorbyl palmitate, 

produced a significant increase in the stability of the oil, even 

higher than that produces by a tocopherol rich extract. 

A second experiment was performed on pretzel dough, using the 

RapidOxy method. The principle of this technique lies in the artificial 

acceleration of the oxidation process by increasing the temperature 

and oxygen pressure, which is in contact with the sample in a 

sealed chamber. This method allows us to measure the oxidation of 

solid products, such as this case. 

References 

1. Amaia Arranz-Otaegui, Lara Gonzalez Carretero, Monica N. Ramsey, Dorian Q. Fuller, and 

Tobias Richter. “Archaeobotanical evidence reveals the origins of bread 14,400 years ago 

in northeastern Jordan” PNAS 

2. Walker, C.E., and Eustace, W.D. “Wheat Processing” Encyclopedia of Food Grains, vol. 3, 

Elsevier Ltd., 2016, pp. 299–304 

3. Murielle Maire, Barbara Rega, Marie-Elisabeth Cuvelier, Paola Soto, Pierre Giampaoli. 

"Lipid oxidation in baked products: Impact of formula and process on the generation of 

volatile compounds”. Food Chemistry 141 (2013) 3510–3518 

4. B. Nanditha, P. Prabhasankar. “Antioxidants in Bakery Products: A Review”. Critical 

Reviews in Food Science and Nutrition, 49:1–27 (2009) 

5. S. S. Sahi, Campden BRI. “Applications of natural ingredients in baked goods” Natural 

Food Additives, Ingredients and Flavourings, 318-332 

6. A. Sayago, M.I. Marín, R. Aparicio, y M.T. Morales. “Vitamina E y aceites vegetales” 

GRASAS Y ACEITES, 58 (1), ENERO-MARZO, 74-86, 2007 

7. Bailey’s Industrial Oils and Fat Products: Sixth Edition, Six Volume Set. Chapter 12. 

Edited by Fereidon Shahidi (2005). John Wiley & Son, Inc 


BTSA 

Tecnoalcalá Calle Arroba 4. 28805 

Alcalá de Henares, Madrid, Spain 

info@btsa.com 

www.btsa.com 


Oil and fats 

Photo © : AdobeStock/anaumenko 

Valuable fats 

Virgin coconut oil and MCT oil: effective 

energy suppliers 

The coconut is a real all-rounder: 

the nectar of its flowers yields valuable 

coconut sugar, whilst refreshing 

coconut water is obtained from green 

and unripe coconuts. Coconut milk is 

a prized vegan and lactose-free milk 

substitute and the fatty flesh of the 

coconut is used to make many pro ducts 

besides milk, such as high-quality 

virgin coconut oil and special MCT oil. 

These oils are particularly valuable for 

their medium-chain fatty acids, since 

this makes them important suppliers of 

energy. Import Promotion Desk (IPD) 

supports Sri Lankan producers of virgin 

coconut oil and MCT oil and accompanies 

them to the European market. 

Special fatty acids 

Once the coconut is cracked, the inside 

comes to light. If the coconut is ripe this 

consists mainly of fruit flesh, with very little coconut water left. 

The white flesh tastes sweet and slightly nutty. It contains a mix of 

minerals, such as potassium, sodium, iron and magnesium, plenty 

of fibre and few carbohydrates. Also, the wide variety of vitamins in 

the flesh, including vitamin C, B1, B2, B3, B4, B5, B6 and E should 

be highlighted. 

In addition, coconut flesh is high in fat and calories: it has a fat 

content of 36.5 grams per 100 grams. It contains mainly saturated 

fatty acids, that means medium-chain triglycerides (MCT). These fatty 

acids of medium-chain length, i. e. of six to twelve carbon atoms, can 

be split up and digested more easily than the usual dietary fats with 

long-chain fatty acids. Therefore, the body can convert them into 

energy more quickly, making them very effective energy suppliers. 

Example: lauric acid 

One of these medium-chain fatty acids is lauric acid. It was named 

after “Laurus nobilis“, the Latin name for laurel, and the oil of the 

laurel consists largely of lauric acid. Cold-pressed coconut oil is also 

known for its high level of lauric acid, which is said to have an antiviral 

and antibacterial effect, protect against infections and be good 


43

Oil and fats 

for intestinal health. As a skincare product, 

coconut oil is thought to provide protection 

against ticks due to the scent of lauric acid. 

Coconut oil is also used to treat muscle pain. 

Cold pressed: virgin coconut oil 

Photo © : Asian Agro 

To produce cold-pressed coconut oil, known 

as “virgin coconut oil”, the flesh is separated 

from the nut and crushed. Before pressing, 

the fresh, watery flesh must be dried. The 

dried coconut, called “copra”, is then coldpressed 

in an oil mill. Virgin coconut oil is 

neither bleached, hardened nor deodorised. 

The production process has a major influence 

on the quality and possible uses of 

coconut oil. The IPD companies from Sri 

Lanka only offer virgin coconut oil. Through 

modern equipment, analytical procedures 

and quality management systems they have 

specialised in gentle pressing. 

Photo © : Nisudha 


Coconut oil changes its aggregate state 

quickly depending on the temperature: at 

temperatures below 25 degrees, coconut 

oil is solid and white; at temperatures above 

that, it becomes clear and liquid. Coconut fat 

and oil are therefore not different products, 

but are instead coconut oil in solid or liquid 

form depending on the ambient temperature. 

Virgin coconut oil has the typical nutty and 

exotic aroma of the coconut. Due to its high 

content of saturated fatty acids, it is also 

heat-stable. It is therefore well suited for 

cooking and baking, as well as frying and 

deep-frying. Another field of application is 

cosmetics: coconut oil is often used in skin 

care products. 

The coconut island: Sri Lanka 


Sri Lanka is one of the main areas where 

coconut palms are cultivated and the 

fourth largest global exporter of coconuts 

and coconut products. The main focus of 

production is in what is known as the coconut 

triangle between the towns of Kurunegala, 

Chilaw and Puthtalam in the east of the 

island. But outside this region too the island 

state has a great many coconut plantations, 

mainly run by small, family businesses. 


Oil and fats 

The palms grow to between 20 and 25 metres 

high, and the coconuts form in groups in the 

crown. Palm climbers regularly ascend the 

palms to select and harvest the ripe fruits. 

Each palm produces around 70 coconuts 

per year. Even though they grow constantly, 

the main coconut harvest period on Sri 

Lanka is between April and September. 

In 2021, the Sri Lankan government decided 

to convert its entire agricultural sector to 

organic production. Many small farmers 

pay attention to sustainable cultivation on 

their coconut plantations and have always 

refrained from using pesticides due to their 

traditional cultivation techniques. The Sinhalese 

producers in the IPD programme mostly 

work with peasant farmers from the region 

who grow organically. Their coconut products 

carry the EU organic label and often 

also other organic certifications. 

Demand for coconuts 

IPD supports a number of enterprises from 

Sri Lanka in marketing the products they 

make from coconuts, particularly the flesh. 

Among them is, for example, the company 

Nisudha Food Products, which has been 

producing a wide range of coconut products 

for over 20 years. Particularly noteworthy is 

the coconut oil from certified organic coconuts 

that Nisudha produces and exports 

successfully. This is because the demand for 

high-quality virgin coconut oil is particularly 

high in Europe. 

Extracted: MCT oil 

In addition to cold-pressed oil, there is 

another speciality from the coconut: MCT oil. 

This is produced by extracting the mediumchain 

fatty acids from coconut oil. Pure MCT 

oil does not occur in nature and coconut fat 

contains a mixture of fatty acids. The MCT 

fats are therefore obtained through hydrolysis. 

capric acids, with eight and ten carbon atoms, are said to be the two 

most valuable fatty acids, as they are considered to provide energy 

the fastest. 

The company Manchiee de Coco joined the IPD programme in 2019 

and produces not only virgin coconut oil, but also other coconut products, 

including the coconut-based MCT oil. The raw material for this 

is cold-pressed coconut oil. During production, the company ensures 

a high proportion of the valuable caprylic and capric acids from 

natural coconut oil. They are contained in the MCT oil from Manchiee 

de Coco in a ratio of 60:40. 

MCT oil is clear and watery, as well as odourless and tasteless. It 

mixes very well with other liquids and is suitable as an oil in sauces, 

salad dressings, shakes and smoothies. 

Speciality Bulletproof Coffee 

MCT oil is also the central ingredient of the new cult drink Bulletproof 

Coffee. Combining it with butter and coffee results in a high-energy 

and caffeine-rich drink. It is said to increase attentiveness as well as 

performance and concentration. 

IPD partner country Sri Lanka 

IPD has been supporting small and medium-sized enterprises from 

Sri Lanka since 2018, preparing them for the European market and 

introducing them to European traders at trade exhibitions in Europe. 

Besides the textile industry, the agricultural sector plays a leading role 

in Sri Lanka’s export economy. Sri Lanka is the world’s third largest 

tea exporter and is particularly well known for its Ceylon tea. Trading 

with spices, particularly cinnamon and pepper, is also a long tradition. 

Another growing export factor is the coconut and its products. 

IPD connects European importers with the carefully selected 

producers, opening up new buying sources for them and supporting 

them in the procurement process. IPD is funded by the German 

Federal Ministry for Economic Cooperation and Development (BMZ). 

For more information, please visit 

www.importpromotiondesk.de 

Caproic, caprylic, capric and lauric acids 

are referred to as medium-chain fatty acids. 

Coconut oil has a high proportion of lauric 

acid – around 50 percent. There is only a 

small amount of caproic acid, which has an 

unappealing taste and odour. Caprylic and 


45


Photo © : Vitafoods Europe 

Vitafoods Europe returns in May 2022 

Last October, 22,000 nutraceutical professionals came 

together virtually and in person to network, collaborate, 

and share knowledge from across the industry at Vitafoods 

Europe 2021. Now, Vitafoods Europe is back once again – at 

its usual May timeslot – combining an online platform and 

the in-person event in Geneva, to re-connect and inspire the 

nutraceutical community in an ever-changing, and increasingly 

health-conscious, post-COVID world. 

By bringing together popular in-person attractions with a lively virtual 

programme, Vitafoods Europe is cementing its position as the leading 

global event to network, forge long-term collaborations, share ideas, 

source innovative ingredients and new suppliers, discover new 

product development solutions, and hear from technical experts and 

industry thought-leaders. 

This year, visitors will be able to access the Vitafoods Europe online 

platform a week before the live event (2-13 May) to immerse themselves 

in exclusive insight-led content and use the data-driven matchmaking 

tool to conduct virtual meetings. Plus, the online platform and 

SMART technology enables them to plan their visit to Geneva and set 

up in-person meetings in advance to ultimately enhance their experience 

and maximise their time at the live event (10-12 May). 

Vitafoods Europe 2022 highlights 

The comprehensive event agenda explores 

key market trends, plus regulatory complexities, 

packaging and labelling challenges, 

and more – including an enhanced focus 

on pressing industry issues, such as mental 

wellbeing, women in nutraceuticals and 

sustainability. Highlights of this year’s event, 

across online and in person, include: 

Extensive industry expert insights 

With online content and in person presentations 

taking place across 4 theatres – 

including the Main Stage powered by 

Vitafoods Insights, Life Stages, New Ingredients, 

and Probiotics theatres – visitors can 

explore over 90 hours of content across the 

whole event. Expect talks on everything from 

the regulatory landscape for probiotic ingredients, 

to innovative prenatal supplement 

ingredients for child mental health. 



Tailored networking opportunities 

This year’s SMART event format allows for 

global connectivity across both the in-person 

and online platforms. Visitors can find 

and connect with potential partners and 

suppliers before and during the show using 

Informa’s intelligent data-driven matchmaking 

service. Facilitating efficient and 

effective networking, this connects visitors 

and exhibitors with shared goals, the right 

backgrounds and in-demand expertise. 

Discover the latest innovations 

Visitors looking for inspiration for their next 

product can tour the New Product and 

Ingredient Zones to discover the very latest 

ingredient technologies, formulations and 

products, as well as exploring new research. 

Alternatively, the virtual Innovation Tour 

is available in video and audio format, to 

complement the live show experience. 

Deep dive into trending ingredients 

with themed Resource Centres 

For those interested in Omega-3 fatty acids 

or probiotics and gut health, the tailor-made 

Resource Centres offer a deeper dive into 

these trending and expanding market areas 

via bespoke and exclusive expert content. 

Sustainability success stories 

With sustainability moving up the priority 

list for many brands, Sustainability Corner 

enables visitors to explore some of the challenges 

and the success stories, with expertled 

sessions on how the industry can become 

more sustainable. 

Photo © : Vitafoods Europe 

Following the impact of the pandemic on 

consumers globally, as well as the fact that 

many of them have busy and stressful daily 

lives, mental wellbeing is a key focus for 

Vitafoods Europe 2022. This year, Informa is 

also hosting a new Vitafoods Europe Summit 

on the topic, offering an in-depth exploration 

of the important role of nutrition in mental 

wellbeing. Running the day before the exhibition, 

9 May, at the Fairmont Grand Hotel in Geneva, the Summit will 

offer insights into the latest ingredient science and its practical application 

in mental health nutrition solutions. 

As the pace of innovation continues to pick up, and with consumer 

interest in nutrition and health at an all-time high, there’s never been 

a better time to take an active role in the nutraceutical community. 

Vitafoods Europe 2022, which will continue to run in accordance 

with the latest Informa AllSecure standards and local Swiss guidance, 

is once again set to connect the community, facilitate learning 

and discovery, and provide an opportunity to solve the biggest global 

health issues, together. 

For more information, please visit 

https://www.vitafoods.eu.com 

Delve into mental wellbeing 


47

Vitafoods Europe – Preview 

GELITA presents cutting-edge solutions for supplements 

GELITA, the leading manufacturer of gelatin and collagen peptides, 

will be back at Vitafoods in Geneva presenting its latest solutions. 

SOLUFORM and VERISOL ® HST are the new smart solutions to 

realize fortified gummies for a demanding and growing market. 

GELITA ® EC is enabling enteric soft capsules safeguarding sensitive 

ingredients through the aggressive gastric environment. And GELITA 

Health provides turnkey products with scientifically proven BCP ® 

ready to market for the customer in all sales channels. Join our educational 

sessions and accept the GELITA Wellness Challenge on site. 

Healthy but tasty, please 

GELITA developed three brand new products for fortified gummy solutions 

to deliver all the health benefits that consumers are requesting 

while ensuring great taste and texture. Beside all this it secures hassle 

free production. 

SOLUFORM PE – the protein booster for your confectionery! 

SOLUFORM PE is optimized for the production of fruit gummies 

with high protein content. By combining the performance of gelatin 

and the protein source in one functional ingredient, the manufacturing 

of protein enriched gummies gets as easy as possible. 

SOLUFORM SR – next generation gelatin for 

sugar reduced confectionery! 

SOLUFORM SR allows to reduce the sugar concentration of confectionery 

without affecting the texture. Thereby a sugar content of a 

fruit gummy can be cut down from 70 % to 40 %. Furthermore this 

leads to a reduced carbohydrate content. Even no-sugar concepts 

are possible using SOLUFORM SR. 

VERISOL ® HST for next generation beauty gummies! 

VERISOL ® HST is optimized for the production of collagen enriched 

fruit gummies. It replaces both, gelatin and collagen peptides and 

enables a concentration of 15 % BCP ® in fruit gummies without 

affecting the taste and texture of the final product. In this way 

VERISOL ® HST is the perfect solution to cater fortified gummies of the 

beauty from within segment with the required high dosage of BCP ® . 

Safeguard sensitive active ingredients to the intestine 

Consumers have been ingesting nutrients in soft capsules for decades 

due to their ease of swallowing and convenience. While for some 

fills it is important to be released as fast as possible, like analgesics, 

for other sensitive substances it is crucial they are transported safely 

through the aggressive stomach environment to be released only in 

the small intestine. In this way you also can avoid the nagging fishy 

burps caused by an early release of omega 3 in the stomach. 

Instead of applying an acid-insoluble opaque coating to the capsule 

in a second time and cost-consuming production step, GELITA ® EC 

allows production of crystal clear enteric soft caps in one single step 

using existing equipment. 

Innovations for a life in motion 

From concept to shelf, our goal is to provide customers with turn-key 

BCP ® solutions to create innovative products in their selected application 

area from tailor-made recipes to individual packaging. Take 

advantage of the GELITA Health expertise, resources, and network 

to speed-up your go-to-market! Use your own brand or license one 

of the strong international GELITA HEALTH brands – it is up to you. 

GELITA 

www.GELITA.com 

www.GELITA-HEALTH.com 

GELITA at Vitafoods, booth I110 

Taiyo presents innovative concepts 

for natural-based products 

Taiyo launches reformulated protein shake concepts in three flavours, 

and showcases ingredients that support a long-term healthy lifestyle. 

At Vitafoods Europe, functional ingredient expert Taiyo will present 

brand new concepts which address current consumer trends, such 

as healthy ageing, sports nutrition and clean label products. The 

company will showcase new additions to its Sunfiber ® portfolio – an 

all-natural, 100 % soluble dietary fiber – as well as its new Sunfiber ® 

Water Concept, an optimum hydration offering with health-boosting 

properties. It will also present Sunphenon EC, known for its high polyphenol 

and catechin content with proven antioxidant effects. Other 

highlights at the Taiyo stand include functional ingredients such as 

concentrated Moringa seed extract and new Vegemeat concepts. 

With Sunphenon EC, Taiyo offers a new variant in addition to existing 

green tea extracts. This product in the Sunphenon range is rich 

in epicatechin, which is found predominantly in cocoa and green 

tea, and has a proven positive effect on the cardiovascular system. 

Furthermore, a decrease in morbidity and mortality from cardiovascular 

diseases is associated with the consumption of flavanols. 1 

Therefore it is perfect for elderly people or other consumers who have 

problems with muscle health, such as muscle atrophy. The product 

has been specially developed for use in instant tea sticks, instant 

beverages or supplements. 

Vitafoods visitors will also be able to learn more about Taiyo’s Chia 

Protein XiaPure ® . Chia seeds are a real health-booster: They contain 

essential amino acids necessary for good health and they are an 

excellent alternative source of protein for sports nutrition. With 

XiaPure ® , a finely milled, high-quality vegan protein powder from 

Chile, Taiyo provides a new formulation for their Vegan Protein 

Shake. The chia protein makes the mouthfeel much smoother and 

Taiyo’s ingredients: Sunfiber ® , Raw Coffee Powder and SunActive ® 

Zinc deliver added nutritional value. The concept can be used for 

ready-to-drink shakes or protein-enriched ice cream, and is available 

in three different flavours. 



The third innovation Taiyo is presenting is the Sunfiber ® Water 

Concept. With this novelty, Taiyo addresses different target groups, 

including the ageing population. This generation often does not 

consume enough water or vital nutrients. This unique concept, 

however, allows for the production of isotonic drinks that contain less 

sugar and additional dietary fibre, allowing for much higher bioavailability 

of minerals. It is also possible to customize such beverages by 

adding more active ingredients such as Q10 or curcumin, depending 

on the target group. For example, children or athletes could benefit 

from the Sunfiber ® Water Concept, as these groups are dependent 

on a targeted nutrient intake. 

Other highlights at the Taiyo stand include the various Sunfiber ® 

Blends with different added health benefits, as well as Moringa, 

a standardised leaf powder with 1 % glucomoringin that has antiinflammatory 

properties, and new concepts surrounding the peabased 

meat alternative Vegemeat for various consumer groups.Dr 

Stefan Siebrecht, Managing Director at Taiyo’s German subsidiary, 

says: “The Corona crisis has had a major impact on consumers 

interest in healthy eating. More and more people are questioning the 

ingredients in a product, and increasingly want natural and plantbased 

alternatives. Taiyo presents solutions and products with which 

the industry can meet these demands.” 

1 

Heiss, C., C. L. Keen and M. Kelm (2010). "Flavanols and cardiovascular 

disease prevention." Eur Heart J 31(21): 2583-2592. 

TAIYO 

www.taiyogmbh.com 

Taiyo GmbH at Vitafoods, booth F90 

Rousselot ® set to inspire at Vitafoods 2022 with 

new consumer study into its unique collagen matrix 

for joint care 

Rousselot ® , Darling Ingredients’ health brand and the global leader 

of collagen-based solutions 1 , invites visitors to booth I114 at Vitafoods 

2022 to discover its latest collagen and gelatin ingredient innovations. 

At this year’s event, Rousselot’s exhibition will reintroduce its all-inone 

collagen matrix designed to provide joint care solutions for a wide 

range of consumer demographics. In addition, the company will spotlight 

the benefits of porcine collagen ingredients and its SiMoGel 

gelatin solution for innovative nutraceutical gummies. 

Visitors to Rousselot’s booth can also make use of the Live Chat 

Corner, allowing them to connect and discuss with formulation 

experts and also explore tailored technical solutions for their specific 

formulation challenges. 

Presenting a new perspective on senior joint care 

In less than 30 years, the number of people aged 60 years and over is 

expected to double, reaching a total of 2.1 billion 2 . In parallel to these 

demographic changes, the market value of dietary supplements 

aimed at supporting mobility is forecast to grow by 4.7 % CAGR by 

2026 3 . The stage is set for a new generation of nutritional solutions, 

formulated to support bone and joint health and help an aging global 

population keep fit into later life. On Tuesday 10 May at 2:30pm at 

the Life Stages Theatre, Dr. Sara De Pelsmaeker, Global Business 

Development Health & Nutrition at Rousselot will unveil the findings 

of a wide-ranging new study to help brands address these shifting 

consumer trends. Through her speech, entitled ‘Joint care innovation 

with an all-in-one collagen matrix, fueled by new consumer-based 

science’, attendees will discover the impact of Rousselot’s collagen 

matrix on the real-world joint care of more than two-hundred people, 

all varying in age, gender, and activity level. 

Broadening access to science-backed collagen solutions 

The company’s flagship collagen brand, Peptan ® is a fully bioavailable 

collagen peptide ingredient which delivers a world of science-backed 

health benefits, from joint support and bone health, to enhanced skin 

and hair beauty. At this year’s Vitafoods event, Rousselot will highlight 

the specific advantages of Peptan P, an accessible premium-quality 

collagen solution of porcine origin that offers a fast route to market. 

Event attendees can experience the functional and sensory properties 

of Peptan P on-stand, through specialized samples, including 

an oat-based breakfast solution tailored for the nutritional needs of 

seniors. 

Innovative gelatin solutions for center-filled functional gummies 

With an attractive appearance, taste and texture that makes them 

easy to swallow, the appeal of nutritional gummies is easy to understand. 

Manufacturing this type of delivery format however, can be 

a difficult task, as traditional starch molding techniques present a 

risk of active pharmaceutical ingredient (API) cross-contamination. 

Rousselot’s innovative SiMoGel gelatin solution means manufacturers 

can produce functional, liquid-center filled gummies using an 

inherently hygienic, starch-free molding technique. These innovative 

‘gummy caps’ allow for higher and more accurate API dosing, with 

virtually no risk of interaction with the gelatin excipient. SiMoGel’s 

unique potential can be discovered in person at Rousselot’s booth, 

where visitors can sample liquid-center gummies with Ibuprofen, 

along with other inspiring application prototypes for the all-in-one 

collagen matrix. 

1 

Global Gelatin Market Insights Forecast to 2026, Calibre Research, 

2020. 

2 

The World Health Organisation, Aging and Health, October 2021, 

https://www.who.int/news-room/fact-sheets/detail/ageing-andhealth#:~:text=By%202050%2C%20the%20world's%20population,2050%20to%20reach%20426%20million 

3 

Euromonitor 

Rousselot ® 

www.rousselot.com 

Rousselot ® at Vitafoods, booth I114 


49


Keep fit and active into later life 

Euromed presents its extended range of Mediterranean fruit and 

vegetable extracts for healthy ageing and wellbeing 

At this year's Vitafoods Europe, Euromed will showcase its well-known 

standardised herbal extracts, the Earth Harmony Organic Extracts ® , 

as well as a growing portfolio of natural ingredients inspired by the 

health-promoting properties of the Mediterranean diet. In addition to 

lemon, olive, fig, artichoke and pomegranate fruit extracts, the iconic 

botanical manufacturer will also showcase its recently launched 

sports nutrition ingredient, the spinach-derived Spisar ® . Visitors to 

the Euromed booth will learn more about the latest research findings, 

health benefits and various applications of these high-quality 

extracts, suitable for inclusion in pharmaceutical, nutraceutical, 

cosmeceutical, food and beverage finished products. 

An ever-increasing older population wishing to stay well into later life 

is driving demand for products that support an active and healthy lifestyle. 

Euromed’s Wellemon ® , Pomanox ® , Mediteanox ® , ABAlife ® and 

Cynamed ® extracts perfectly tap into this trend, as they contain valuable 

nutrients that play a key role in the Mediterranean diet and have 

been proven to support cardiovascular, metabolic, antioxidant, digestive, 

immune and skeletal muscle functions, all of which are critical 

for healthy ageing. 

Inspired by this nutritional model, Euromed will be highlighting its 

portfolio of extracts and presenting its new Spisar ® spinach extract. 

Obtained from the nutrient-rich leaves of spinach cultivated in 

southern Spain, it is gently processed with the Pure-Hydro Process ® , 

an eco-friendly, proprietary extraction technology that uses only purified 

water as a solvent. Spinach leaves have a naturally high content 

of phytoecdysteroids, plant secondary metabolites with a wide range 

of potential physiological and health benefits, such as improved 

physi cal performance and skeletal muscle fitness. Spisar ® is standardized 

for 20-hydroxyecdysone (20E) – the major naturally-occurring 

ecdysteroid in plants. 

Researchers from the Sports Physiology Department at the Universidad 

Católica San Antonio de Murcia (UCAM) 1 , in Spain, investigated 

the efficacy of daily consumption of Spisar ® spinach extract 

compared to placebo in combination with moderate-intensity skeletal 

muscle strength training. 

The results of the 12-week randomised, double-blind, placebocontrolled 

trial revealed that supplementation with Spisar ® significantly 

improved muscle strength and muscle quality in subjects aged 

over 50 compared to a placebo. The published study also highlighted 

improvements in muscle mass and quality, as well as quality of life. 

The authors concluded that Spisar ® in conjunction with physi cal exercise 

may exert overall “all-body strengthening” adaptogenic activity, 

and may be beneficial for improving and maintaining muscle health 

and fitness, both of which are crucial for healthy ageing. 

Andrea Zangara, Head of Scientific Communications & Marketing, 

says: “It’s clear that the older generation wants to delay the decline in 

physical capacity that comes with age for as long as possible. Preventive 

and active measures will help promote mobility and strength. 

Both the newly launched and existing Mediterranean fruit and vegetable 

extracts will help our customers meet this market demand.” 

1 

Pérez-Piñero, S.et.al (2021): A 12-Week Randomized Double-Blind 

Placebo-Controlled Clinical Trial,Evaluating the Effect of Supplementation 

with a Spinach Extract on Skeletal Muscle Fitness in Adults 

Older Than 50 Years of Age. Nutrients 2021, 13, 4373. 

Euromed S.A. 

www.euromedgroup.com 

Euromed at Vitafoods, booth C94 

Impressum 

ISSN 2364-8104 

Wellness Foods & Supplements | No. 1 /2022 

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