ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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10000 1000 Too Many Chemicals Too Little Data (%) 100 10 1 9912 IRIS TRI Pesticides Inerts MPV CCL 1 & 2 HPV Office of Research and Development Computational Toxicology Research Program 60 50 40 30 20 10 0 Acute Cancer Gentox Dev Tox Repro Tox 3
4 Robotic Platform Pathway Office of Research and Development Computational Toxicology Research Program High Throughput Screening 101 (HTS) 96-, 96 ,38 384-, , 1536 536 Well e Plates ates Target Biology (e.g., Estrogen Receptor) Chemical Exposure Cell Population 4 HTS: High Throughput Screening
Page 1 and 2: ToxCast and Tox21: High Throughput
Page 3: Exposure p Grand Challenge for Comp
Page 7 and 8: HTS iin TToxicology i l Test priori
Page 9 and 10: GGoals l of f TToxCast C t and dT T
Page 11 and 12: Comparison p of Volumes for Screeni
Page 13 and 14: ToxCast Phase I ToxCast Phase I and
Page 15 and 16: Assays Chemicals Office of Research
Page 17 and 18: micals Chem Digitizing Legacy in Vi
Page 19 and 20: ToxCast: Multiple Assays and Techno
Page 21 and 22: No Pathology Proliferative Lesions
Page 23 and 24: Office of Research and Development
Page 25 and 26: ToxPi: Prioritizing Chemicals for P
Page 27 and 28: Expanding the ToxPi Approach for Pr
Page 29 and 30: Future ToxPi (Toxicological Priorit
Page 31 and 32: Systems Approaches to Modeling Toxi
Page 33 and 34: Office of Research and Development

ToxCast and Tox21: High Throughput Screening for Hazard & Risk ...

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