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A Handbook on

ChemoBrain

with Molecular and

Clinical Background

(Cancer- and Chemotherapeutic- related Cognitive Dysfunction)

Editor

Assoc. Prof. Özgür TANRIVERDİ

NOBEL TIP KİTABEVLERİ


SCIENTIFIC COMMITTEE

Assoc. Prof. Ayşegül Yıldız, Ph.D.; Muğla Sıtkı Koçman University Faculty

of Science, Department of Molecular Biology and Genetics, Muğla

Dr. Burcu Mustan, M.D.; Muğla Sıtkı Koçman University Faculty of Medicine,

Department of Internal Medicine, Muğla

Assist. Prof. Leman İnanç, M.D.; Muğla Sıtkı Koçman University Faculty

of Medicine, Department of Psychiatry, Muğla

Assoc. Prof. Müesser Özcan, Ph.D.; Muğla Sıtkı Koçman University Faculty

of Medicine, Department of Medical History and Ethics, Muğla

Assoc. Prof. Özgür Tanrıverdi, M.D., M.Sc.; Muğla Sıtkı Koçman University

Faculty of Medicine, Department of Medical Oncology, Muğla

Assist. Prof. Rabia Mihriban Kılınç, M.D.; Muğla Sıtkı Koçman University

Faculty of Medicine, Department of Radiodiagnostics, Muğla

Dr. Selçuk Uylaş, M.D.; Muğla Education and Research Hospital, Practitioner

Physician, Muğla

Dr. Turan Karaoğlu, M.D.; Bodrum State Hospital- Bodrum Army Aviation

Training and Exercise Central Command, Practitioner Physician,

Muğla & Research Assistant in Oncological Clinical Researches Center of

Mugla Sitki Kocman University Oncology Department, Mugla

Prof. Ümmühani Özel Türkçü, M.D.; Muğla Sıtkı Koçman University

Faculty of Medicine, Department of Medical Biochemistry, Muğla

Yeşim Kaya, M.Sc.; Muğla Sıtkı Koçman University Faculty of Science, Department

of Molecular Biology and Genetics, Muğla

v


PREFACE

Despite current dazzling advances in cancer treatment, cancer still ranks second

among the most important causes of death and is an important cause of morbidity,

given the side effects of anti-cancer treatment. Cancer survivors and cancer patients

in remission after systemic anti-cancer treatments suffer from chronic and

long-term side effects that they have a negative impact on quality of life. Chemotherapy-related

cognitive dysfunction (Chemobrain) is one of these side effects

and there is no clear consensus regarding both etiopathogenesis and diagnostic approach.

Hypothesis regarding the inflammatory and proinflammatory processes,

genetic and epigenetic changes, are the most accepted mechanisms for chemobrain

which is thought to contribute to other conditions such as cancer-related fatigue

and anemia in etiopathogenesis. Because of the contradictory studies about objective

measurement tools used in clinical evaluation, it is thought that biomarker or

radiological imaging methods can also be used. In spite of all clinical, molecular

and radiological studies, the known information about chemobrain has a very limited

information volume besides the unknown ones. Therefore, chemobrain is a

true phenomenon beyond psychiatric and cancer-related symptoms, and further

molecular and clinical studies may increase treatment options in the future. In this

article, the literature about chemobrain is discussed on molecular basis as well as

clinical features and morbidity results.

In this handbook, the literature about chemobrain is discussed on molecular basis

as well as clinical features and morbidity results.

Assoc. Prof. Özgür Tanrıverdi,

M.D for Internal Medicine & Medical Oncology

M.Sc. for Molecular Biology & Genetics

PhD Candidate for Gerontology (Elderly Health)

vii


Contents

CHAPTER 1

CHAPTER 2

CHAPTER 3

CHAPTER 4

CHAPTER 5

CHAPTER 6

CHAPTER 7

CHAPTER 8

CHAPTER 9

CHAPTER 10

Basic Information on Neuronal Biology....................................1

Ayşegül Yıldız

Molecular Mechanisms of Neurodegeneration.........................7

Ayşegül Yıldız

Biochemical Basis of Cognitive Disorders..............................11

Ümmühani Özel Türkçü

Basic Clinical Information on Cognitive Disorders...............17

Leman İnanç

General Clinical Information about Cognitive Disorders

In Patients with Cancer............................................................31

Selçuk Uylaş, Burcu Mustan

Molecular Biological Basis of Cognitive Disorders In

Cancer.......................................................................................39

Özgür Tanrıverdi

Molecular Studies on Cognitive Disorders Associated

with Cancer Treatment.............................................................47

Yeşim Kaya

Radiological Diagnosis of Cognitive Disorders Associated

with Cancer or Cancer Treatment...........................................53

Rabia Mihriban Kılınç

Risk Factors and Treatment Options of Cancer- or

Chemotherapy- Related Cognitive Disorders.........................63

Turan Karaoğlu

Ethical Dilemmas for Elderly Cancer Patients with

Cognitive Function Disorder...................................................69

Müesser Özcan

CHAPTER 11

Neuronal Regeneration............................................................75

Ayşegül Yıldız

ix

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