ICF, Rivista dell'Industria Chimica e Farmaceutica

ANNOXIII NO3 2022SUPPLEMENT 

INTERNATIONAL TRADE FAIRS 

SPECIAL ISSUE 

RIVISTA 

DELL’ 

INDUSTRIA 

CHIMICA E 

FARMACEUTICA 

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01_03_SUMMARY.indd 1 25/07/22 09:31

RIVISTA 

DELL’ 

POSTE ITALIANE SPA - SPED. IN ABB. POSTALE 

70% - LO/MI - COSTO COPIA €10,00 

Summary 

RIVISTA 

DELL’ INDUSTRIA 

CHIMICA E 

FARMACEUTICA 

icf 


icf 

INTERNATIONAL FAIRS 

SPECIAL EDITION 

INDUSTRIA 

CHIMICA E 

FARMACEUTICA 

DESTINATION PHARMA 

ANNOXIII NO3 2022SUPPLEMENT 

Construction 

Engineering 

Commissioning 

Qualification 

Process 

Equipment 

Supply 

Equipment 

Manufacturing 

Containment 

Solution 

4Editorial 

A strong sector 

in an uncertain economic 

environment 

16 

Bioeconomy 

“Innovation and circularity 

should be linked together” 

20 

Achema Preview 

Achema 2022 focuses 

on massive challenges 

for the process industry 

API Trading 

www.csv-ls.com 

6Economy 

Pharmaceutical industry: 

a key asset to the European 

economy 

10 

News 

Skill and reliability working 

for pharmaceutical and 

chemical industries 

18 

Exhibitions 

The networking and 

knowledge platform for 

processing and analysis 

28 


A complete range 

of sealing systems 

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Summary 

2 icf RIVISTA DELL’INDUSTRIA CHIMICA E FARMACEUTICA 

01_03_SUMMARY.indd 2 25/07/22 09:31

Summary 

NO.3 2022 - SUPPLEMENT 

30 


38 

Chemical industry 

A prominent position 

in the chemical raw 

materials distribution sector 

44 

Validation 

Consulting GMP, training 

and auditing: the new 

Ellab services 

50 

Machines 

Mixing technology, 

a very important support 

in the pharma process 

62 

Instrumentation 

64 


Endress+Hauser lays the 

groundwork for the future 

42 


-70% greenhouse gas 

emissions in the last decade 

46 

Safety 

Systems for controlled 

atmosphere environments 

54 

Components 

58 

Digital transition 

Engagement as key for 

Digital Transformation 

68 

Tribology 

Take back control 

48 

Safety 

72 

Advertising list 

Colophon 

“The innovation element, which involves biological resources, can never be 

replaced by circularity. It’s something in addition. For that reason, we need both. 

They might not be integrated, but they should be linked together.” 

Christian Patermann, co-founder and honorary chair of the World Bioeconomy Forum’s 

advisory board, page 17 

NO.3 2022 - Supplement 

RIVISTA DELL’INDUSTRIA CHIMICA E FARMACEUTICA icf 3 

01_03_SUMMARY.indd 3 26/07/22 10:53

Editorial 

A strong sector in an uncertain 

economic environment 

The healthcare sector in the world will 

exceed 8 trillion euros in 2025, if the 

estimates of Pharmintech Monitor, the 

document issued on Pharmintech, the 

exhibition held in Milan last Spring, are 

confirmed. It is clear that the multiple 

and intertwined emergencies underway 

globally - from war to inflation, climate change 

and energy crisis - make any forecast uncertain. 

Yet in this gloomy context, pharma currently appears 

to have good stability and prospects for further 

growth. Within the overall health sector, which 

is supposed to advance from now to 2025 with an 

average rate of 1.9% per year, the pharmaceutical 

industry stands out for its vitality, so much so that 

it grew by 7.9% in 2021 and justifies estimates for 

an increase of 3.9% per year over the next three 

years. These numbers are higher than those estimated 

before the advent of the pandemic. It is therefore 

fairly easy to deduce that the fight against coronavirus 

has played a decisive role in the evolution 

of this industry. Of the 1,113 billion euros that express 

the world value of the international pharmaceutical 

market in 2021, 78.3 billion are attributable 

to vaccines alone. However, other life sciences 

are also growing - nutraceuticals, cosmeceuticals, 

biotechs, biomedicals - niches destined to expand, 

with expected double-digit growth rates over the 

next three years. Back to the impact of Covid19, the 

Pharmintech Monitor highlights that, starting from 

2020, not only has the demand for products linked 

to the production of vaccines increased, but also 

that for therapies against the acute phase 

of the disease, as well as the treatments 

of Covid long-term symptoms. Research 

& development on therapeutic vaccines 

and experimental treatments has also been 

drastically intensified. But the whole supply 

chain, up to the pharmacy, was crossed 

by completely new dynamics that 

led operators to rapidly change 

to adapt to a scenario never seen 

before. This reactivity made it 

possible, after the initial loss, to 

quickly re-establish the continuity 

of production and the capillarity of distribution: 

from the supply of active ingredients to the pharmacist’s 

shelf close to home. On the other hand, 

especially in hospital pharmaceuticals, medicines 

for therapies considered “temporarily” less urgent 

have slowed down. The situation is expected to return 

to greater balance by 2023. The next few years 

will be featuring above all an exponential increase 

in demand from less advanced but faster-growing 

countries. The fastest-growing rates of the pharmaceutical 

industry between 2016 and 2025 are in Nigeria 

(+239.2%), Chile (+165.9%), India (+122.7%), 

Bangladesh (+121.5%) and Poland (+115%), compared 

to a world average rate of +66% with Italian 

growth, in 10 years, accounted for + 28%. So pharma 

is on the move all over the world, but in some 

countries the growth will be disruptive. 

by Alessandro Bignami 


04_05_EDITORIAL.indd 4 25/07/22 09:40

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Economy 

In 2021 year the world come 

through a Global Financial 

Crisis and a huge pandemic 

but EFPIA companies 

have more than 

doubled production, 

increased exports 

and build up a 

pharmaceutical 

industry which is 

vital to Europe’s 

economy. 

Pharmaceutical industry: 

a key asset to the European 

economy 

by Eva De Vecchis 

Efpia, the European federation 

of Pharmaceutical industries 

and Association complied a 

report about the Pharmaceutical 

Industry in Figures 2022 

that reveals a keystone of the European 

economy at a pivotal moment in 

its history. 

Nathalie Moll – who joined the European 

Federation of Pharmaceutical 

Industries and Associations 

(EFPIA) as Director general in April 

2017 – argues that thank’s to this 

report is possible to get a sense of 

just how pivotal the research-based 

industry is to Europe’s economic 

and health future. 

Thanks to advances in science and 

technology, the research-based pharmaceutical 

industry is entering an exciting 

new era in medicines development. 

Research methods are evolving 

and we have many promising prospects 

on the horizon, with groundbreaking 

cell and gene therapies being 

increasingly available. The innovative 

pharmaceutical industry is 

driven by, and drives, medical pro- 

gress. It aims to turn fundamental 

research into innovative treatments 

that are widely available and accessible 

to patients. 

Already, the industry has contributed 

to significant improvements in 

patient well-being. Today’s European 

citizens can expect to live up to 30 

years longer than they did a century 

ago. Some major steps in biopharmaceutical 

research, complimented by 

many smaller steps, have allowed for 

reductions in mortality, for instance 

from HIV/AIDS-related causes and 


06_09_ART_efpia.indd 6 25/07/22 10:05

Economy 

several cancers. High blood pressure 

and cardiovascular diseases can be 

controlled with antihypertensive and 

cholesterol-lowering medicines; knee 

or hip replacements prevent patients 

from immobility; and some cancers 

can be controlled – or even cured – 

with the help of new targeted treatments. 

European citizens can expect 

not only to live longer, but to live 

better quality lives. Yet major hurdles 

remain, including Alzheimer’s, Multiple 

Sclerosis, many cancers, and rare 

diseases. 

As well as driving medical progress by 

researching, developing and bringing 

new medicines that improve health 

and quality of life for patients around 

the world, the research-based pharmaceutical 

industry is a key asset of 

the European economy. 

Main trends 

The research-based pharmaceutical 

industry can play a critical role in restoring 

Europe to growth and ensuring 

future competitiveness in an advancing 

global economy. In 2021 it 

invested an estimated 41,500 million 

in R&D in Europe. It directly employs 

some 840,000 people and generates 

about three times more employment 

indirectly – upstream and downstream 

– than it does directly (PwC, Economic 

and societal footprint of the pharmaceutical 

industry in Europe, June 

2019). However, the sector faces real 

challenges. Besides the additional 

regulatory hurdles and escalating 

R&D costs, the sector has been severely 

hit by the impact of fiscal austerity 

measures introduced by governments 

across much of Europe since 2010. 

There is rapid growth in the market 

and research environment in emerging 

economies such as Brazil, China 

and India, leading to a gradual migration 

of economic and research activities 

from Europe to these fast-growing 

markets. 

During the period 2016-2021 the 

Brazilian, Chinese and Indian markets 

grew by 11.7%, 6.7% and 11.8% 

respectively compared to an average 

market growth of 5.8% for the top 5 

European Union markets and 5.6% for 

the US market (source: IQVIA MIDAS, 

May 2022). 

In 2021 North America accounted 

for 49.1% of world pharmaceutical 

sales compared with 23.4% for 

Europe. According to IQVIA (MIDAS 

May 2022), 64.4% of sales of new 

medicines launched during the period 

2016-2021 were on the US market, 

compared with 16.8% on the Eu- ropean 

market (top 5 markets). 

The importance of R&D 

All new medicines introduced into 

the market are the result of lengthy, 

costly and risky research and development 

(R&D) conducted by pharmaceutical 

companies. 

By the time a medicinal product reaches 

the market, an average of 12-13 

years will have elapsed since the first 

synthesis of the new active substance. 

The cost of researching and developing 

a new chemical or biological entity 

was estimated at 1,926 million 

($ 2,558 million in year 2013 dollars) 

in 2014 (DiMasi et al, Journal 

of Health Economics, January 2016). 

On average, only one to two of every 

10,000 substances synthesised in 

laboratories will successfully pass all 

stages of development required to 

become a marketable medicine. 

In 2020 the pharmaceutical industry 

invested more than 39,600 million 

in R&D in Europe. A decade of strong 

US market dominance led to a significant 

shift of economic and research 

activity towards the US during the 

period 1995-2005, a trend that has 

been exacerbating since 2015. Additionally, 

Europe is now facing increasing 

competition from emerging 

economies: rapid growth in the 

market and research environments 

in countries such as China and Korea 

are contributing to the move of 

economic and research activities to 

non-European markets. In 2021 China 

nearly equalled Europe as orig- 

EFPIA member 

associations 

(official figures) 



06_09_ART_efpia.indd 7 25/07/22 10:05

Economy 

EFPIA member 

associations 

(official figures) 

- (e): EFPIA 

estimate 

inator of new active substances 

launched for the first time on the 

world market, with respectively 18 

and 19 new substances, far behind 

the US leading with 35 on a total of 

95. The geographical balance of the 

pharmaceutical market – and ultimately 

the R&D base – is likely to 

shift gradually towards fast-growing 

emerging economies. 

According to Eurostat data, the pharmaceutical 

industry is the high technology 

sector with the highest added 

value per person employed, significantly 

higher than the average value 

for high-tech and manufacturing industries. 

The pharmaceutical industry 

is also the sector with the highest 

ratio of R&D investment to net sales. 

According to the 2021 EU Industrial 

R&D Investment Scoreboard, health 

industries invested about 188.7 billion 

in R&D in 2020, accounting for 

20.8% of total business R&D expenditure 

worldwide. 

Employment in the pharmaceutical 

industry 

Recent studies in some countries 

showed that the research-based pharmaceutical 

industry generates about 

three times more employment indirectly 

– upstream and downstream 

– than it does directly (PwC, Economic 

and societal footprint of the 

pharmaceutical industry in Europe, 

June 2019). Furthermore, a significant 

proportion of these are valuable 

skilled jobs, for instance in the 

fields of academia or clinical science, 

which can help maintain a high-level 

knowledge base and prevent a European 

“brain drain”. 

“Take the number of people employed 

in our sector: among all the 

data packed in this report, this is one 

of the numbers that translates most 

readily to people”, comments Nathalie 

Moll. “Of course, the 840,000 

individuals directly employed in Europe’s 

pharmaceutical sector is not 

the whole picture. 

There is a significant multiplier effect 

which includes all those people, 

companies and partners providing 

services to the industry whose 

jobs we rely on; from plumbers to 

academics, CROs and SMEs, caterers 

to logisticians”. 

A look to the future 

The world pharmaceutical (prescription) 

market was worth an estimated 

1,062,707 million ($ 1,256,863 

million) at ex-factory prices in 2021. 

The North American market (USA & 

Canada) remained the world’s largest 

market with a 49.1% share, well 

ahead of Europe, China and Japan. 

Distribution margins, which are generally 

fixed by governments, and VAT 

rates differ significantly from country 

to country in Europe. On average, 

approximately one third of the retail 

price of a medicine reverts to distributors 

(pharmacists and wholesalers) 

and the State. 

All this informations contained in 

the 2022 report, can be a good starting 

point to figure out how pharma 

can contribute both to health and 

wealth in a key moment for policy 

development on the continent. 

“We must take a long-term strategic 

view of where we are as a region 

and where we are goin”, says 

Nathalie Moll. “Company leaders and 

life-science investors, who can invest 

in any industry in any country or region, 

need to have confidence in the 

long-term outlook: in the innovation 

ecosystem, in access to talent, in the 

market. Despite the clear and positive 

contribution of the pharmaceutical 

industry to Europe’s economy, we 

are facing a number of challenges. Escalating 

costs and regulatory hurdles 

are making R&D more difficult, while 

the impact of fiscal austerity measures 

introduced across Europe since 

2010 continue to affect today’s revenues 

and influence key decisions on 

bringing innovation to market. At the 

same time, we have seen the growth 

of Brazilian, Chinese and Indian markets 

outstrip growth in the top 5 European 

markets. Our global competitors 

have prioritised life sciences and we 

must respond with similar ambition.” 

“That’s where Europe’s pharmaceutical 

and industrial strategies come 

in. It is vital that Europe rises to the 

challenge and develops the policies 

needed to ensure the European pharmaceutical 

sector is an innovator and 

world leader”. 

 


06_09_ART_efpia.indd 8 25/07/22 10:05

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06_09_ART_efpia.indd 9 25/07/22 10:05

News 

Skill and reliability working for pharmaceutical and chemical industries 

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To date, CSV Active mainly 

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Following the new European regulations 

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active ingredients a production activity. 

Thus the company has therefore 

organized itself in a more structured 

way, by introducing a new office – the 

Quality Unit – and adopting a system 

complying with GMP. 

In 2019 AIFA, following an inspection, 

authorised CSV Active as Pharmaceutical 

Workshop, also approving 

the 5 products presently available 

in the catalogue: omega 3, thiopronine, 

azithromycin, fluconazole 

and camphor. Always focusing on 

customer care quality and relying upon 

the Group, CSV Active has reached 

an agreement with an external warehouse, 

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In fact, there are many services that 

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News 

Get your 

GSK selects Target the Future 

grant recipient 

GSK PLC announced the first recipient of the Target the Future Think 

Tank Challenge £70,000 (equivalent to approximately $100,000) 

grant to the HealthTree Foundation, a non-profit organisation helping 

patients learn more about their health and become their own 

best advocates. Their proposal, the “HealthTree Equity and Diversity 

for Multiple Myeloma Program,” will improve access, education 

and support for underserved communities and minority patients. 

Tania Small, Vice President, Global Head of Oncology Medical Affairs 

and Head of R&D Diversity, Equity and Inclusion at GSK, said: “The 

response to this challenge showcased an abundance of innovation, 

creativity and ingenuity, which we need to address patients’ unmet 

needs. We see great potential in the HealthTree Foundation’s proposal, 

which goes beyond the science to improve access, equitable 

care and quality of life for the multiple myeloma community.” 

GSK’s grant will help support the HealthTree Foundation as it develops 

digital delivery tools to distribute information on treatments 

and trials, facilitate digital communities and expand outreach efforts 

to support, educate and provide more equitable care to multiple 

myeloma patients. 

Jenny Ahlstrom, Founder and CEO of the HealthTree Foundation, 

said: “I am alive today because I had the right information 

and treatments, and we must extend that access to communities 

of colour. GSK saw problems and created a programme to target a 

better future.” 

Specifically, the Target the Future grant from GSK will aid in the 

expansion of two of the following initiatives at the HealthTree 

Foundation: 

- “Black Myeloma Health”: Outreach from the HealthTree Foundation 

will expand to spotlight Black patients with multiple myeloma 

and their experiences through video journaling and distribution 

of new educational brochures with information about relevant 

treatments and resources. 

- “HealthTree for Mieloma Multiple”: The organisation’s efforts 

to support multiple myeloma patients will increase through deployment 

of Spanish-speaking patient navigators who will help 

people get answers along their treatment journey in their native 

language. 

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ac22_ICF_95x247.indd 1 17.05.2022 14:47:45 


News 

University of Brescia, Antares Vision and Dompè Farmaceutici: 

agreement for the future’s healthcare 

A research and innovation infrastructure for the development 

of Digital Healthcare, Biopharma, Artificial Intelligence, 

and Big Data will be created with the contribution of Next 

Generation EU. 

The University of Brescia has 

signed an agreement with Antares 

Vision Group, an Italian product 

and chain quality traceability 

and control multinational, and 

with Dompè Farmaceutici Spa, a 

leading Italian company in the 

bio-pharmaceutical sector, for 

the development of an integrated 

system of infrastructures that will 

expand by approximately 2,000 

sq.m. the Technological Multisector 

Service Centre in the building 

owned by the University inside 

the North university campus. 

The project, the result of a public 

and private partnership which 

has collected EUR 19.5 million in 

funds, known as L.I.G.H.T. – Lifescience 

Innovation Good Healthcare 

Technology – will develop 

healthcare technologies pursuing 

three important goals: 

• AI and Big Data Main Hub: largescale 

analysis, storage, and construction 

of platforms for sharing 

the data collected, creation and 

update of websites. 

• Digital Health Care Hub: development 

of a smart hospital with 

geo-referenced rooms and beds 

equipped with sensors and communication 

systems for continuous 

monitoring, development of 

telemedicine digital technologies, 

and for improved remote control 

of the patient, creation of drug 

tracking solutions that aim to 

protect the quality and integrity 

of the medicinal products themselves 

and reduce administration 

errors or counterfeiting. 

• AI Biopharma Hub: development 

of a fully integrated structure 

based on artificial intelligence 

that can design, synthesise, 

and define the activity of 

new drugs and bio-pharmaceuticals, 

in collaboration with the EX- 

SCALATE platform of Dompé farmaceutici 

S.p.a. 

The L.I.G.H.T. infrastructural project 

is consistent with the 17 Sustainable 

Development Goals of the 

2030 Agenda signed by the members 

of the UN and focuses on 

the Green New Deal. 

It is in line with goal no.3 “Good 

health and well-being” as it 

aims to develop new technological 

solutions for healthy 

and ill patients, and to design 

a smart hospital prototype. 

It complies with the principles 

of goal no.5 “Gender equality” as 

all governing bodies of the infrastructure 

will be designed in conformity 

with the gender equality 

principles. 

It aims to reach goal no.9 “Industry, 

innovation and infrastructure” 

as its purpose is to design 

an infrastructure where public and 

private entities exchange ideas 

and experiences for a new open 

innovation system, with three 

targets: a) increasing the contact 

and meeting points between 

basic research and industrial research 

to create new solutions for 

health and well-being; b) set up 

new innovative undertakings; c) 

revise the curricula for the training 

of new professional figures in 

the medical field and in the field 

of new technologies for health. 

A strong partnership between 

public and private entities 

“The main goal of the initiative 

is to strengthen the collaboration 

between the University of Brescia 

and private companies aiming 

at a more in-depth integration of 

basic research skills with skills in 

industrial and experimental research”, 

states the Chancellor, 

Prof. Maurizio Tira. “Moreover, 

the project will have a significant 

impact on knowledge that can be 

applied to the digital transition 

of healthcare providers”. 

“Technological Innovation Infrastructures 

- adds Prof. Marina 

Pizzi, Vice Chancellor for research 

- represent vital initiatives 

for Italian research that must 

prove that they are able to integrate 

to an increasing degree in 

the years to come, following the 

PNRR (Italy’s recovery and resilience 

plan), with significant effects 

for the entire national research 

system and its technological 

transfer into products that citizens 

can use”. 

”We are proud to partner with the 

University of Brescia in this project 

that, thanks to its concreteness, 

we believe can trigger a virtuous 

circle of contacts and partnerships 

among various entities 

in our country. In the words of 

Emidio Zorzella, Chairman and Co- 

CEO of Antares Vision Group, “We 

have always believed in research, 

in innovation, and in a multidisciplinary 

approach as a driver for 

growth, transformation, and sustainability”. 

”The collaboration between public 

and private entities and open 

innovation have, for some time, 

been one of the driving forces of 

the research carried out by Dompé 

farmaceutici” commented Marcello 

Allegretti, Chief Scientifc Officer 

of the Milan-based company. 

“I believe that our EXSCALATE 

platform, which is based on artificial 

intelligence and supercomputing, 

can make a significant 

contribution towards the success 

of the initiative, producing new 

knowledge, accelerating drug discovery 

times, and consolidating 

the scientific network with new 

partners”. 



Catalysts used, consist 

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metals. 

 

 

guarantees: 

 

down to 0.2 µm 

Temperature: 

up to 925 °C 

 

 

 

 

Fast pay-back 

Environmental safety 

 

 

Materials: 

20+ alloys 

available 

 

 

arrangement for 

 

H.Q. 

Asco Filtri S.p.A. 

 

September/October 2020 

 

ASCO Filtri S.p.A. - This and much more 


News 

ISPE Foundation celebrates Gilead’s impact 

on the pharmaceutical industry 

On 9 June, ISPE President and CEO Thomas Hartman, and ISPE 

Foundation Board Chair Antonio Moreira, PhD, visited Gilead’s 

headquarters in Foster City, California to present Joydeep Ganguly, 

Senior Vice President, Corporate Operations, with a recognition 

award for his support in developing a critical and diverse 

pool of talent necessary for accelerating the delivery of 

transformational medicines to patients worldwide. 

They were thrilled to also meet with Abbey Kim who was part 

of the inaugural ISPE Foundation Diversity Internship Program 

at Gilead Sciences in 2021, where she now works as an automation 

engineer. 

Thomas was invited back to join in on the celebration of Gilead’s 

35th anniversary on 22 June, which also marked the opening 

of both the Gilead Sciences Park and their Wellbeing Center. 

The ISPE Foundation said it is proud to partner with companies 

such as Gilead Sciences, and leaders like Joydeep, to champion 

programs that create opportunity, diversity, and success within 

the global pharmaceutical industry. 

Chiesi acquires therapeutic monoclonal antibodies portfolio against EMAP II 

Chiesi Farmaceutici Spa (Chiesi Group), the international research-focused 

pharmaceutical and healthcare group, entered into an agreement 

with Allinaire Therapeutic, LLC, a company founded by BioMotiv, to acquire 

the world-wide rights to a portfolio of therapeutic monoclonal antibodies 

(mAbs) against endothelial monocyte-activating polypeptide 

II (EMAP II) for the potential treatment of PAH. 

EMAP II is a non-classical cytokine which impacts apoptosis, cell injury, 

endothelial cell function and inflammation. Based on the pioneering 

work by the scientific founders, Matthias Clauss, PhD and Irina Petrache, 

MD, and their colleagues at Indiana University and National Jewish 

Health, Allinaire and their network of preclinical and clinical scientists, 

have demonstrated a pivotal pathogenic role of EMAP II in cardiopulmonary 

diseases, including PAH, chronic obstructive pulmonary 

disease (COPD), and viral-induced acute lung injury. They developed anti-EMAP 

II mAbs which are currently being progressed in early phases, 

as a potential disease-modifying treatment for PAH and are the subject 

of this partnership. 

PAH is a rare disease with an incidence of 2–5 per million adults.. PAH is 

a progressive disorder characterised 

by high blood pressure in the arteries 

of the lungs that can lead to right 

heart failure. Current approved medications 

mainly address the symptoms 

of this rare condition and there 

is an unmet medical need for novel 

approaches that could delay, or reverse, 

the disease progression. 

“This agreement is further evidence 

of Chiesi’s commitment to seek out 

novel treatments for conditions with 

a high unmet medical need such as 

PAH” commented Thomas Eichholtz, Head of Global R&D of Chiesi Group. 

“We believe that an anti-EMAP II mAb is a promising novel approach 

for the treatment and slowing of disease progression for patients with 

PAH. The partnership with Allinaire is further evidence of Chiesi’s focus 

on innovation and desire to accelerate our entry into biologics and 

thus diversify our therapeutic platforms”. 

According to Douglas W.P. Hay, CEO and CSO of Allinaire, “We have made 

excellent progress in our anti-EMAP II mAb program at Allinaire, working 

with a multi-disciplinary team of experts in EMAP II science, biologics, 

and cardiopulmonary disease therapeutics. We are extremely excited 

to be partnering with Chiesi, a world-class global pharmaceutical 

company with a long-standing and successful track-record in this therapeutic 

area, to advance this novel class of medicines”. 

Allinaire will receive an upfront payment, future milestone payments 

and net sales royalties. 

The agreement with Allinaire follows Chiesi’s recent €85m investment 

to build the Biotech Center of Excellence Plant in Parma (Italy), dedicated 

to the development, production, and distribution of biological 

products. In recent years the group 

has also undertaken a series of new 

strategic partnerships with external 

partners, including Moderna and Cyclica, 

to strengthen their work in biotechnology. 

The development of biological 

products has continued to increase 

over the last 10 years. On the global 

market, the sector has grown at 

an annual rate of more than 12% 

in the last 30 years and will double 

by 2030. 



News 

Stevanato Group publishes the Sustainaibility Report 

Stevanato Group S.p.A., a leading global provider of drug containment, 

drug delivery, and diagnostic solutions to the pharmaceutical, 

biotechnology, and life sciences industries, announced the 

publication of its Sustainability Report 2021. The report showcases 

the Group’s holistic approach to sustainable development and 

highlighted strong guidance aimed at pursuing goals pertaining 

to economic sustainability, its responsibility to innovation and 

new products, employees, and the environment. 

This is the first year that Stevanato Group publishes a report 

on its approach to sustainability, comparing its performance to 

the Global Reporting Initiative (GRI) Standards. The Company is 

striving to provide comprehensive and transparent information 

to demonstrate its unwavering commitment to sustainability. 

The report covers Stevanato Group’s rapid response to the COV- 

ID-19 outbreak, as the Company increased production capacity to 

support its customers’ efforts to combat the global crisis. As part 

of this effort, Stevanato Group provided glass vials and syringes 

to approximately 90% of existing vaccine programs, according 

to estimates based on public information (WHO, EMA, FDA); 

as well as plastic diagnostic consumables for the detection and 

diagnosis of COVID-19. 

“As we approach one year since the Company’s IPO on the New 

York Stock Exchange, we are united in our commitment to supporting 

our customers on the single-minded goal of enhancing the integrity 

of medicines to help people live a better life,” said Franco 

Moro, Chief Executive Officer of Stevanato Group. “To do this, we 

have collaborated with our partners and the scientific community, 

and invested in R&D, to make greater strides toward better economic, 

environmental, and social sustainability – for our Company, 

customers, and the communities we live in.” 

In 2021, Stevanato Group focused on areas that were of high 

materiality for the Company as well as key stakeholders. In line 

with its business strategy, primary attention was given to two 

main areas: product quality and responsibility, and research & 

development and innovation. Other focus areas were closely associated 

with human resources, such as occupational health & 

safety and human capital management and development, highlighting 

the importance of Stevanato Group’s policies toward 

people. The report also illustrates the positive results and different 

actions taken to improve sustainability towards the environment, 

reducing water consumption and waste in Stevanato 

Group’s productions. 

Processes 

to know. 

Solutions 

to go. 

27.9 -29.9.2022 

NORIMBERGA, GERMANIA 

La fiera leader per il trattamento e l‘analisi delle 

polveri e dei solidi sfusi 

VIVERE LE DINAMICHE, 

OTTIMIZZARE I PROCESSI, CONDIVIDERE LE CONOSCENZE 

Venite a scoprire l‘ingegneria dei processi meccanici in tutta la sua ampiezza e dinamicità alla 

più grande fiera internazionale dei beni strumentali. Toccate con mano gli oggetti in esposizione. 

Cogliete questa occasione di approfondimento professionale e di scambio tra esperti. 

Novità di quest’anno: 

L‘industria di processo incontra l‘industria dell‘imballaggio. Aspettatevi l‘intera catena del 

valore, dalla produzione al confezionamento dei prodotti. 

Una combinazione di proposte pronta a convincervi! 

powtech.de/become-visitor 

Sponsor onorari 

Parallelamente a FACHPACK – La fiera 

europea del settore dell‘imballaggio, 

della tecnologia e della lavorazione 

PT-22_Ad_General_194x121mm_IT.indd 1 23.05.22 10:25 


Bioeconomy 

Photo by Croda 

“Innovation and circularity 

should be linked together” 

Christian Patermann, co-founder of World Bioeconomy Forum outlines how 

to make broader use of renewable biological resources: “The bio-based 

sector works very slowly, but steadily”. 

Christian 

Patermann, 

co-founder and 

honorary chair 

of the World 

Bioeconomy 

Forum’s 

advisory board 

A 

growing bio-based chemical 

industry is critical to the 

transition towards a carbon 

neutral and circular bioeconomy 

to extend the lifecycle 

of products, minimize waste, efficiently 

use renewable raw materials and develop 

bio-based products (BBPs). 

“We started in 2005 with the bioeconomy 

and now we have 30-35 countries, 

including China as of May 2022, 

and maybe the same number of regions 

with bio-strategies,” says Christian 

Patermann, co-founder and honorary 

chair of the World Bioeconomy 

Forum’s advisory board. “But what 

is missing is the breakthrough in the 

minds of decision-makers and the population 

at large. I don’t expect that very 

soon. The bioeconomy works very slowly, 

but steadily.” 

The European Commission defines the 

bioeconomy as “using renewable biological 

resources from land and sea like 

crops, forests, fish, animals and micro-organisms 

to produce food, materials 

and energy.” The circular bioeconomy 

involves extending the lifecycle 

of such products by recycling or reusing 

them. 

Patermann, points to the potential of 

bio-based rhamnolipids for detergents; 

HFDA for nylon, coatings and adhesives; 

aniline for aromatics; and polyethelene 

glycol for additives and surfactants 

found in many chemical platforms 

today. “These products directly 

and indirectly reduce fossil carbon us- 

age all over the world,” he says. 

According to Cefic’s position paper, biobased 

products are still a small part 

(2.5%) of the overall European bioeconomy, 

which has a turnover of approximately 

2.4 trillion. About 50% of this 

is generated by food and beverages, 

around 25% from agriculture and forestry, 

and the remaining 25% in the 

pharmaceutical, pulp and paper, textile, 

fuels and energy sectors. 

The need for both a bioeconomy 

and circularity 

For Patermann, the pursuit of circularity 

needs to go hand-in-hand with the development 

of the bioeconomy. For example, 

the toxicity of substances, such 

as some textile dyes, is not reduced or 


16_17_articolo cefic.indd 16 25/07/22 10:21

Bioeconomy 

eliminated by recycling or biodegradability. 

Plus, a lot of recycling processes 

need enormously large volumes of water 

and energy. In order to reduce the 

toxicity of chemicals and make natural 

resources for recycling climate-friendly, 

microorganisms, enzymes and other 

biological resources can be utilised. 

“The innovation element, which involves 

biological resources, can never 

be replaced by circularity,” Patermann 

says. “It’s something in addition. For 

that reason, we need both. They might 

not be integrated, but they should be 

linked together.” 

To this end, Europe is striving for a 

circular, sustainable bioeconomy and 

eventually, a bio-based circular economy 

as well, he adds. “Bio-based circularity 

is very evident in quite a few 

products and processes of the chemical 

industry.” 

The use of non-food crops and secondand 

third-generation feedstocks (biowaste 

and residues) is particularly important 

given the disruptions to global 

food, feed and fuel supplies with the 

war in Ukraine, notes Patermann. He 

predicts the food versus fuel debate will 

end as the bioeconomy focuses on materials 

that are not in direct competition 

with food and feed. “The next five 

years will be very decisive.” 

Are there enough non-food 

feedstocks to go around? 

“If we really exploit the enormous 

amount of waste, in particular urban 

waste – which has been completely neglected 

up to now – we have a tremendous 

canopy of opportunities,” Patermann 

states. “And that’s just the beginning… 

The volume of urban waste 

cannot be compared to anything you 

have in a rural area.” 

There is also an opportunity for the 

“repatriation of value chains and supply 

chains,” Patermann says. For example, 

northern Germany is cultivating 

Russian dandelion to supplant rubber 

trees from Southeast Asia in areas 

where food crops cannot grow to supply 

the automotive industry with a renewable 

source for tires. 

Biological resources cannot yet replace 

all raw materials, but they might one 

day, Patermann adds, noting the potential 

of enzymes, fungi and other microorganisms 

in the chemical industry. 

He estimates that more than half of the 

chemicals in raw materials still need to 

be discovered in order to find bio-replacements. 

“The chemical industry should work much 

harder to build up sustainable future 

developments through education, training 

and funding for green chemistry. It has the 

power to do that” 

Engaging the private sector 

in the bioeconomy 

How can the private sector be incentivised 

to invest and innovate in the 

bioeconomy? “The best incentive is a 

successful showroom of innovative, affordable 

products to show the value 

of using waste and biomass to create 

new products,” Patermann responds. 

“We will need, at least for certain period 

of transition, some public help like 

the U.S. BioPreferred Program,” which 

facilitates public procurement of biobased 

products. It’s also important to 

level the playing field for all stakeholders 

and offer equal access to new markets, 

he adds. 

The bioeconomy should first be introduced 

in school, then continue at 

the university level with green chemistry 

curricula, Patermann says. Master 

courses in green chemistry are already 

available in Austria, Finland, France, 

Latvia and Switzerland. The chemical 

industry can also collaborate with universities 

and offer its personnel lifelong 

learning. For example, Cefic organises 

green chemistry boot camps. 

Processes involving bio-based feedstocks 

play an increasingly important 

role in the bioeconomy. For example, 

an enzymatic process for the interesterification 

(rearrangement of fatty acids) 

of oils and fats avoids production 

of harmful trans fatty acids. In addition 

to eliminating these artery-clogging 

substances, the process reduces 

the use of toxic chemicals and water, 

prevents vast amounts of by-products 

and reduces waste. 

“The chemical industry is one of the 

last industrial branches in Europe that 

still has a strong lead globally,” Patermann 

concludes. “With its influence 

today, it should work much harder to 

build up sustainable future developments 

through education, training and 

funding for green chemistry. That would 

be very good for Europe and the planet. 

The chemical industry has the power 

to do that.” 

 

(Source: Cefic) 



16_17_articolo cefic.indd 17 25/07/22 10:21

Exhibitions 

The networking and 

knowledge platform for 

processing and analysis 

At Powtech 2022, trade visitors will experience 

the latest equipment and systems for mechanical 

processes for the processing, analysis 

and handling of powder, granulate and bulk solids 

The mix of numerous innovations 

and expert-to-expert 

dialogue makes Powtech the 

networking and knowledge 

platform for process technicians 

and engineers. Decision-makers 

and buyers will find competent 

advice here for their investment decisions. 

From 27 to 29 September 

2022, trade visitors will experience 

the latest equipment and systems 

for mechanical processes for the 

processing, analysis and handling 

of powder, granulate and bulk solids 

in four halls, including the state-ofthe-art 

Hall 3A. This year’s trade fair 

duo, Powtech and Fachpack, expects 

over 1,600 exhibitors from Europe - 

around 500 of whom will be exhibiting 

at Powtech in the field of mechanical 

processing technology and 

analysis. Both trade fairs bring together 

the entire value chain from 

process to technology to packaging. 

The respective ticket is valid for both 

trade fairs. 

Powtech brings together the global 

innovations for mechanical process- 

ing technology as well as for the analysis 

and handling of powders, granulates 

and bulk solids. Plant planners 

and operators from almost all industries, 

including food and feed, chemicals 

and pharmaceuticals, construction, 

recycling and ceramics, come 

together to update their knowledge, 

examine state-of-the-art process 

technology and prepare and make 

investment decisions. Trade visitors 

experience three days of high-quality 

technology live in action, inspiration 

and exchange at eye level, and a 

varied supporting programme. 

“Powtech has always been the exhibition 

where process engineers and 

production managers from every industry 

have found very concrete solutions 

to their requirements and also 

their problems,” says Heike Slotta, 

Executive Director NürnbergMesse. 


18_19_art_powtech.indd 18 25/07/22 10:31

Exhibitions 

“When networking on the stands, but 

also through the specialist forums, 

where presentations on current issues 

in the industry take place on 

an ongoing basis and leading manufacturers 

and users share compact 

best practices.” 

This year, visitors to Europe’s leading 

trade fair exclusively for powder, 

granulate and bulk solids technologies 

will also benefit from synergies 

created with the simultaneous 

staging of Fachpack, trade fair for 

packaging, technology and processing. 

With one trade fair ticket, visitors 

gain access to both events and 

the expected more than 1,600 exhibitors. 

Shaping the future together 

Whether mixing, crushing, agglomerating 

or separating material that 

has a powdery or lumpy aggregate 

state in the course of the manufacturing 

process - the systems and 

machines are decisive for the production 

processes of many industries. 

In dialogue with visitors and 

exhibitors, future topics of modern 

production will be discussed in the 

open atmosphere of Powtech in four 

halls, including important sustainability 

topics such as resource efficiency, 

recycling or CO 2 

-neutral production, 

but also topics relating to 

the working world of tomorrow and 

attracting skilled workers and talent. 

Professional programme 

for trade visitors 

In lectures, seminars, live demonstrations, 

guided tours and special 

shows, powder and bulk solids professionals 

from every sector will receive 

useful practical knowledge 

from top-class speakers. Bulk solids 

practitioners meet in the Expert Forum 

“stagetalks”. Here, for example, 

the focus will be on innovative processes 

for modern battery and energy 

storage production. In the food sector, 

one topic will be protein shifting 

in the drying of vegetable protein 

sources. For users from the pharmaceutical 

industry, the Pharma.Manufacturing.Excellence 

forum will offer 

inspiration on the subjects of pharmaceutical 

processing and pharmaceutical 

packaging. 

The special show “Dust recognises 

boundaries – free trade doesn’t” by 

the VDMA Group Air Purification and 

Drying Technology shows how the air 

in production facilities can be kept 

clean. The topic of explosion protection 

will not be neglected either. In 

the outdoor area of Powtech there 

will be daily controlled live demonstrations 

on explosion protection - 

including spectacular bang and fire 

effects. At the joint stand “Innovation 

made in Germany”, national 

start-ups and young companies 

will show interesting innovations in 

the industry. 

Longstanding exhibitors 

need no persuading 

One thing is certain: trade fairs like 

Powtech will continue to be a key 

tool for business success in the future. 

This view is also shared by longstanding 

Powtech exhibitors who 

can hardly wait for the fair to take 

place in 2022. They include Rainer 

Zimmermann, CEO of AZO GmbH 

& Co. KG, one of the world’s most 

experienced companies in the automated 

handling of raw materials, 

who says: “Two years of pandemic 

and enforced breaks have shown us 

that there is no substitute for personal 

contact in the trade fair environment. 

We are therefore even 

more delighted that Powtech, the 

leading fair for bulk solids and powder 

technology, can also take place 

again this year. Barely any other 

event offers AZO such a good opportunity 

to present our expertise 

in the automated handling of raw 

materials. And this year, the parallel 

Fachpack show offers visitors 

yet another opportunity for personal 

exchanges about our AZO products 

and solutions.” 

Gerold Rogge, Regional Sales Manager/Key 

Accounts of Coperion 

K-Tron GmbH, a globally operating 

supplier of process equipment, is 

full of praise for the leading trade 

fair for mechanical processing technology: 

“Without a lot of ‘bells and 

whistles’, visitors have direct access 

to the ‘who’s who’ of bulk solids 

technology. They can discuss upcoming 

projects directly with qualified 

stand personnel, which can often 

result in solutions being found 

there and then. And that’s exactly 

what makes these face-to-face discussions 

better than the virtual experience. 

Finally, we will also be able 

to offer a hands-on display of our 

latest developments to the professional 

community.” 

 

This year, visitors 

to Powtech will 

also benefit 

from synergies 

created with 

the simultaneous 

staging of 

Fachpack, 

trade fair for 

packaging, 

technology and 

processing 

(Photos by 

NürnbergMesse) 



18_19_art_powtech.indd 19 25/07/22 10:31


Achema 2022 focuses 

on massive challenges 

for the process industry 


20_23_art_achema.indd 20 25/07/22 10:40


The transformation towards a climate-neutral chemical industry, the topic 

of digitalisation, the global political situation, the difficulties of the energy 

sector and supply chain networks. The world’s leading show for chemical 

engineering, process engineering and biotechnology will offer answers 

and solutions to these and many more questions. 

In addition to the transformation 

towards a climate-neutral 

chemical industry and the 

perennial topic of digitalisation, 

the current global political 

situation also poses massive 

challenges for the process industry. 

do we shape the necessary political 

framework and incentives? Which financial 

instruments are required? 

These questions will be addressed at 

the opening event of Achema entitled 

“Climate-Neutral Chemical Industry“ 

on 22 August 2022 from 5 pm 

Northern Lights, and Ernst Rauch, 

Chief Climate and Geo Scientist of 

Munich Re, joining the panel. 

Green Innovation Zone shows solutions 

for a more sustainable future 

The challenges and solutions for 

Which technologies can be used to 

achieve defossilisation? How to secure 

and enhance regional and global 

supply chain networks? And what 

hurdles must be overcome in the digitalisation 

of the industry? Achema 

2022 offers answers and solutions to 

these and many more questions. 

Europe aims to become climate-neutral 

by 2050. In line with this target, 

the chemical industry is working 

on technologies to achieve this 

goal. What are the opportunities, 

challenges, and obstructions? How 

at the end of the first exhibition day. 

After the welcome address and opening 

of Achema by Klaus Schäfer, 

Chief Technology Officer of Covestro 

AG and Chairman of Dechema 

e.V., Martin Brudermüller, President 

of Cefic – The European Chemical 

Industry Council and CEO of BASF 

SE, will present the perspective of 

the European chemical industry in 

his keynote speech. Open questions 

will be discussed in the subsequent 

panel discussion, with Martijn Smit, 

Business Development Director of 

a more sustainable future are also 

addressed by the “Green Innovation 

Zone”: this special area 

brings together pioneers, experts 

and solution providers from industry, 

politics, and science with decisionmakers 

and users. The Green 

Innovation Zone highlights green 

innovations and the challenges 

faced by the process industry 

on its way to climate-neutral production. 

Five areas in particular 

will be in the spotlight at Achema: 

climate-neutral production, 



20_23_art_achema.indd 21 25/07/22 10:40


circular economy, industrial water, 

sustainable chemistry, biobased 

economy. 

“The process industry will have to 

electrify its facilities across the 

board and use hydrogen as an energy 

source in the medium term if it 

wants to live up to its responsibility 

for sustainable value creation,” 

adds Frank Jenner, Global Chemicals 

& Advanced Materials Industry 

Leader at EY, the main green innovation 

partner of Achema 2022. 

“The industry is already going to 

great lengths and it’s a huge challenge, 

but it can be done.” 

“With this year’s Achema – perhaps 

more than ever – we are sending out 

a signal that technological cooperation 

across industry boundaries, 

but also across national borders, is 

indispensable for solving the significant 

crises of our time“, says 

Thomas Scheuring, CEO of Dechema 

Ausstellungs-GmbH. Björn Mathes, 

Member of the Board of Dechema 

Ausstellungs-GmbH, adds: “As an 

industry platform, we can create a 

nucleus in our lecture formats and 

in the discussions at the stands, in 

which the industry works together 

on a solution.” 

Digital Hub and Digital Lab offer 

digitalisation at your fingertips 

The topic of digitalization has finally 

claimed a top spot on the 

agenda of the process industry. The 

new exhibition group “Digital Hub“ 

contributes to this: it is the central 

meeting point for digital experts 

and all participants interested 

in or actively involved in the 

digital transformation of the process 

industry. The exhibition area 

with a central stage puts digital 

showcases of the process industry 

in the spotlight and offers the latest 

insights from experts and solution 

providers and facilitates future-oriented 

discussions. 

A total of six use cases for the connected 

and digitalized laboratory 

will be presented at the Digital Lab 

Action Area – the smart lab of tomorrow 

to experience, touch and try out. 

Equipment and software manufacturers 

will demonstrate cross-manufacturer 

digitalization solutions using 

relevant practical examples. The 

spectrum ranges from Cobot-assisted 

work processes for sample preparation 

and analysis, user-oriented 

process control with Laboratory Execution 

Systems, to horizontally and 

vertically connected yet modularly 

adaptable equipment solutions with 

the perspective of shared laboratory 

infrastructure and seamless integration 

between sample input and 

quality-assured analysis results. Innovative 

software and device solutions 

are supported by the Laboratory 

& Analytical Device Standard 

(LADS) for OPC UA. 

“Digitalisation, sustainability, security 

of supply – the challenges 

ahead are enormous and can only be 

overcome together and across sectors”, 

says Thomas Scheuring. “Let 

us therefore use Achema in August 

2022 as the world’s only comprehensive 

showcase of the latest technology 

trends in our industry to find 

and tackle solutions together.” 

Even more integrated exhibition 

and congress program 

This year, for the first time, Achema 

will fully integrate the congress 

into the exhibition programme. All 

congress sessions will take place either 

on stages directly in the exhibition 

halls or in the immediate vicinity 

of the exhibition groups. Another 

change to the Congress is that there 

will be five theme days instead of 

three this year. Daily highlight sessions 

within the respective themes 

will emphasize additional topics, ensuring 

that all topics driving the process 

industry are addressed. 

“True to the Achema motto 'Inspiring 

Sustainable Connections', we are 

bringing together what belongs together,“ 

says Dr Andreas Förster, Executive 

Director of Dechema and organiser 

of Achema. “Application and 

research go even more hand in hand 

at Achema 2022 thanks to the closer 

thematic and spatial integration 

of the exhibition and congress programme.“ 

On Monday (22 August 2022), the 

theme “Hydrogen Economy“ will kick 

off the event. The “Fossil Free Production“ 

theme day on Tuesday (23 August 

2022). The focus topic of Achema, 

“The Digital Lab“, will be part 

of the Wednesday (24 August 2022) 

theme day on “Perspectives in Laboratory 

& Analytics“. The continuous 

hot topic “Digitalisation in Process 

Industry“ can be found as part of the 

new exhibition group “Digital Hub“ 

(Hall 12.1) and also as a focal point 

of the Congress programme agenda on 

Thursday (25 August 2022). The last 

day of the congress on Friday (26 August 

2022) will focus on “Novel Bioprocesses 

and Technologies”. 


20_23_art_achema.indd 22 25/07/22 10:40

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20_23_art_achema.indd 23 25/07/22 10:40

Achema Preview preview 

Zero-loss philosophy: the flexibility 

of robotics to avoid waste 

Steriline is presenting a Robotic Vial Filling and Capping 

Machine under isolator (RVFCM50) and a Robotic Nest Filling 

Machine under double-wall isolator (RNFM5). 

After four years, Achema, the international 

trade show for the process 

industries that attracts visitors 

from all over the world, is 

back. Steriline is presenting a Robotic 

Vial Filling and Capping Ma- 

can be checked in real-time during 

filling operations and the recipe 

parameters can be met. 

Once they have been properly 

filled, the vials are moved to the 

second robotic arm for the stop- 

Hall 3.1 - 

Booth E69 

erations while vials are positioned 

on the weighing cells with a refill 

function. 

This is controlled through sophisticated 

software based on feedbacks 

from the high-precision 

weighing cells the filling pumps 

are equipped with, which are 

tasked with autonomously adjusting 

refilling interventions. 

protects the operator at the same 

time. This new robotic line will allow 

the customer, a Contract Development 

and Manufacturing Organization 

(CDMO), to further differentiate 

its offer, processing a 

wide range of packaging solutions, 

and to add toxic products 

to its own portfolio. 

After the successful delivery in 

2021 of a pilot line for the primary 

packaging of small batches, 

the customer’s order for this 

line comes as a testament of its 

1 2 

1: Steriline Robotic 

Vial Filling Machine 

2: Steriline Robotic 

Vial Capping Machine 

chine under isolator (RVFCM50) 

and a Robotic Nest Filling Machine 

under double-wall isolator 

(RNFM5). 

The RVFCM50 can process up 

to 2,400 pcs/h. Once vials are 

washed and depyrogenated, the 

first of three robotic arms grasps 

two vials at the time and places 

them under the filling heads, 

which are linked to two peristaltic 

pumps that potentially allow 

infinite capacity filling. This step 

happens directly on two weighing 

cells, so that the filling volume 

pering process and then to the 

third robotic arm for capping. 

Whenever the check sensors detect 

any non-conformity during 

filling, stoppering or capping, the 

process can be repeated to guarantee 

the conformity needed according 

to the company’s “robotics 

zero-loss philosophy”. 

This methodology, applied at the 

filling, stoppering and capping 

steps, aims to avoid any product 

loss in the fill-finish process. The 

philosophy mainly relies on robots 

that allow smooth filling op- 

In addition, the zero-loss philosophy 

also relies on sensors that detect 

and report to the technician 

missing or incorrectly positioned 

stoppers or caps, with the possibility 

of repeating the closing operations, 

which reduces this type 

of waste associated with standard 

solutions. 

The machine was designed to 

manage highly potent drugs potentially 

dangerous for people 

and, for this reason, it is equipped 

with an isolator that ensures the 

sterility of the processed vials and 

satisfaction with Steriline’s 

solutions and services. 

The RNFM5 under double-wall 

isolator can process 

every container that comes 

in nested form, including 

syringes, vials and cartridges. 

It is equipped with a 

statistical weight-checking 

system at the filling station 

and with Steriline’s patented 

smart bung system at the 

capping station. 

It answers to the client’s need to 

introduce a new production line 

to start the commercialisation of 

a new biotech drug. Its output 

is up to 10,000 pieces/h with a 

double-wall isolator solution that 

guarantees the sterility throughout 

the entire process and the 

maximum safety for operators. 

This solution perfectly satisfies all 

the requirements for the production 

of extremely sensitive drugs, 

such as biosimilars and monoclonal 

antibodies, in addition to biotech 

drugs. 


24_27_news_achema.indd 24 25/07/22 10:49

EXPERIENCE THE POWER 

OF TRUSTPARENCY ® 

THE NEXT-GEN OF DIGITALIZATION 

FOR PRODUCTS AND SUPPLY CHAINS 

Antares Vision Group is an outstanding technology partner in digitalization 

and innovation to guarantee the safety of products and people, business competitiveness 

and sustainability through a unique and comprehensive ecosystem of software and 

hardware solutions for the life science industries: inspection systems and automatic 

machines to ensure product quality, track & trace at line, plant, corporate and government 

level for regulatory compliance and end-to-end traceability, integrated data management 

within the production process and the supply chain. 

WE ARE READY FOR ACHEMA. 

JOIN US AND EXPERIENCE THE 

POWER OF TRUSTPARENCY ® 

hall 3.0 / stand B4 

24_27_news_achema.indd 25 25/07/22 10:49

Achema Preview preview 

A complete range of taylor-made vacuum systems 

Hall 4 - Booth F26 

Thanks to over 80 

years of experience, 

Italvacuum 

is one of the leading 

manufacturers 

of vacuum 

pumps, as well as 

a world-wide reference 

point in the engineering, manufacture 

and supply of vacuum dryers, ensuring 

top-tier performances for the treatment of 

wet powders from filtering and centrifuging 

processes. 

Considering the importance of the use of 

Italvacuum installations, that are quite often 

exploited in the production of Active 

Pharmaceutical Ingredients (APIs), Fine 

Chemicals and Intermediates, the company 

mission has always been to provide the 

customers with the utmost in quality, innovation 

and safety. 

Today, Italvacuum manufacturing capabilities 

include a wide range of original and 

patented equipment and systems including 

single and double stage vacuum pumps, dynamic 

horizontal and rotative vacuum dryers 

and static vacuum tray dryers complying 

with the main international regulations 

(ATEX, UL, PED and ASME) and with the latest 

FDA and cGMP norms. 

Italvacuum is able to provide 

turn-key installations 

and also tailor-made 

equipment and solutions, 

according to customer’s 

process requirements. Italvacuum 

presence all over 

the world, with a continually 

growing number of installations 

in both consolidated 

and emerging markets, is a tangible 

sign of the company’s reliability. 

Customer care, for Italvacuum, means supporting 

the customer from the very first 

contact. Italvacuum offers the opportunity 

to conduct pilot drying trials and involves 

the customer in system design and manufacturing. 

Once the system is up and running, 

Italvacuum also provides all the technical 

support the customer may need to ensure 

year after year of fault-free operation. 

Pilot Trials: the Italvacuum facility comprehends 

a full range of pilot systems for carrying 

out semi-industrial and laboratory scale 

drying tests on customer’s products. 

Project Engineering: technical know-how 

and a thorough knowledge of the needs of 

the chemical and pharmaceutical industries 

have enabled Italvacuum engineering services 

to build up unparalleled expertise in 

vacuum processes. 

After Sales Service: with highly qualified 

personnel, Italvacuum After Sales Service 

provides the following assistance: 1) scheduled 

preventive maintenance; 2) technical 

assistance; 3) service spare parts; 4) system 

upgrading and overhaul. 

Italvacuum is very glad to participate, after 

4 years, at Achema, world’s leading trade 

show for the process industries. 

The company will exhibit all its portfolio of 

vacuum solutions: 

- Saurus939 Vacuum pump with VVB and 

VVC models; 

- Criox System 350 liters, Double-cone rotary 

vacuum dryer with electric lump breaker 

units; 

- Planex System 150 liters, Horizontal paddle 

dryer with eccentric agitator; 

- CosmoDry System 150 liters, Horizontal 

paddle dryer with concentric agitator, 

- Multispray System E0,9 model, Vacuum 

tray dryer with extractable shelves; 

- LaboDry System ESL 2 model, Laboratory 

dryer. 

Ecosystem of solutions to guarantee 

the safety of products and people 

Hall 3.0 - 

Booth B4 

Antares Vision Group provides a unique, comprehensive 

ecosystem of solutions to guarantee 

the safety of products and people, business competitiveness 

and sustainability through digitalization 

and innovation: inspection systems and 

automatic machines to ensure product quality, 

track & trace at line, plant, corporate and 

government level for regulatory compliance and 

end-to-end traceability, integrated data management 

within the production process and the supply 

chain. 

Antares Vision Group is the technology partner 

for the digitalization of products and supply 

chains through a comprehensive ecosystem 

of software and hardware solutions: inspection, 

traceability, data management. 


24_27_news_achema.indd 26 25/07/22 10:49 

Pagin

24_27_news_achema.indd Pagina ADV.indd 1 27 25/07/22 18/05/22 10:49 

09:51


A complete range 

of sealing systems for high 

temperatures 

Texpack is a manufacturer of packings, tapes, twisted ropes, cloths and 

sleeves, for thermal insulation for static use, and produces special packings 

and braided packings with dynamic use for pumps and valves. It produces 

and markets industrial gaskets of different types and sizes, offering 

a complete range of sealing systems and products for high temperatures. 

9TX. 

Spiral-wound 

gaskets 

Texpack® is a manufacturer 

of packings, tapes, twisted 

ropes, cloths and sleeves, for 

thermal insulation for static 

use, and produces special 

packings and braided packings with 

dynamic use for pumps and valves. It 

produces and markets industrial gaskets 

of different types and sizes, offering 

a complete range of sealing 

systems and products for high temperatures. 

5100. PTFE semi-finished products 

The semi-finished product category 

includes PTFE pipes, bars, tubes, 

tapes, ribbons, whasers and sleeves. 

The same can be filled (during processing 

with PTFE powder a percentage 

of specific components is inserted) 

glass, graphite, copper, bronze, 

molybdenum, coal. These special 

compounds improve the mechanical 

and thermal strength of virgin PTFE. 

5100L. PTFE sheets 

PTFE plate, polymer belonging to the 

class of perfluorocarbons (PFC), resulting 

from homopolymerization of 

tetrafluoroethylene. The same plates 

can be made with the addition of other 

stabilizing and thinning components, 

to expand their application range. 

5211. Jointex red 

High quality jointing sheet made 

with pigmented, quartz fillers. It is 

an innovative replacement material 

for asbestos seals and conventional 

products in PTFE. Its special production 

process ensures that the Jointex® 

gaskets have excellent creep resistance 

and tightness with a wide 

range of temperatures and pressures. 


28_29_art_texpack.indd 28 25/07/22 10:58


5212. Jointex blue 

High quality jointing sheet made of 

PTFE with pigmented glass sphere fillers. 

It is an innovative replacement 

material for asbestos seals and conventional 

products in PTFE. The material 

offers valid mechanical properties 

which enable a high sealing 

capacity to be achieved and maintained 

over time. It has excellent 

chemical resistance and good compression 

strength, and does not age. 

5700. PTFE envelope gaskets 

Envelope gaskets consist of an enclosure, 

commonly called an envelope, 

which can be made from the 

more common virgin PTFE and filled 

PTFE (silica, graphite or other). The 

thickness of the envelope is usually 

0.5 mm; this makes the gasket particularly 

suitable for the chemical, 

pharmaceutical and food industries. 

tion of alkaline substances and is 

usually supplied with bi-adhesive 

film which facilitates application. 

6803G. Texgraf Flat Gaskets 

Texgraf® flat gaskets are obtained 

from a sheet of flexible expanded 

graphite into which a tanged foil 

with a thickness of 0.1 mm made of 

AISI 316 has been inserted. 

6804G. Metaltex 

Metaltex represents a Texpack evolution 

in the assembly technology 

sector, guaranteeing a longer gasket 

lifetime. In fact, Metaltex belongs 

to the Texpack family of flat gaskets 

reinforced with graphite, which feature 

a special characteristic that increases 

seal performance: the presence 

of an inner reinforcement ring. 

Visit Texpack at Achema. 

Hall 8.0 Stand G61 

TEXPACK ® Srl 

Via Galileo Galilei, 24 - 25030 Adro (BS), Italia 

Phone: +39 030 7480168 - Fax: +39 030 7480201 

info@texpack.it - www.texpack.it 

9TX. Spiral-wound gaskets 

The spiral-wound gaskets are made of 

metal tape with a specially shaped profile 

coupled with a filler tape (graphite, 

ceramic or glass fibre, PTFE or mica), 

both uniformly wound with constant 

winding tension. The unique metal profile 

has an elastic action that guarantees 

a perfect seal under all fluctuating temperature 

and pressure conditions. They 

can be assembled to a centring ring that 

may be external, internal or both. 

3350 - 3360. Valve 

and flange covers 

Made of brown and black PTFE-coated 

glass fabric (with or without pH test 

strip). Valve cover and flange cover are 

made of a brown PTFE-coated glass fabric 

with thickness 0.254 mm or 600 g, 

black. Harnesses for side fasteners and 

flame retardant Velcro. A pocket with 

a hole can be inserted on request, in 

which the pH test strip can be applied to 

check the leak, by the change of colour. 

5500. Texlon self-adhesive 

soft tapes 

A self-modelling gasket tape made 

of soft and flexible non-sintered expanded 

100% PTFE. Texlon® resists 

chemical products with the excep- 

6610I. Sealflex jointing sheets 

Jointing sheets made of cellulose fibres, 

mineral fibres and fillers, NBR 

based elastomer binder. 

4131A. PTFE FDA 

This is a packing composed of pure PT- 

FE yarns, which is impregnated yarn-byyarn 

with PTFE dispersion, and formed 

using a diagonal braiding method. This 

packing has a low coefficient of friction 

on the shaft and a high resistance to 

chemicals. 



28_29_art_texpack.indd 29 25/07/22 10:58


80 years of filtration and flow control experience 

Hall 12.0 - 

Booth D21 

Mott & ASCO combined 

have over 80 years of filtration 

and flow control 

experience in critical industries 

including specialty 

and bulk chemical processing. 

Mott & ASCO provide 

complete site needs 

for filtration ranging from 

disposable filter media to 

semi automated systems, 

through coalescing technology 

and fully automated 

self-cleaning catalyst 

recovery filtration skids. 

In addition to the standard 

range of filtration products, 

the company’s engineering 

division provides complete 

filtration packages to engineering 

companies and 

end users alike, designed 

and manufactured according 

to all the main construction 

codes and standards 

(ASME VIII Div 1&2, 

PED etc.) building on the 

combined resources of an 

engineering team. To satisfy 

the requirements of the 

oil & gas and petrochemical 

sectors, ASCO Filtri and 

Mott can also provide pressure 

vessels and systems 

with U-Stamp 1&2 and/or 

CE Stamp. 

Hall 8.0 - 

Booth H22 

Solid handling plants 

Hall 3.1 - 

Booth A69 

Hydraulics pump with 

open channel impeller 

To expand the already wide range of hydraulics 

Salvatore Robuschi will present at Achema a new 

series with open channel impeller available in 

both horizontal and vertical versions. The pump 

is intended for sugar mills, fertilizer production, 

the paper industries and all situations where an 

open impeller with wide passages is required. It 

is suitable for viscous liquids even containing dissolved 

gases, offers a low NPSH and guarantees 

good performance and stability even with high 

dry matter content. 

CO.RA. Srl is leader in “made 

in Italy” production in solid 

handling systems for finished 

and semi-finished products 

for the chemical and pharmaceutical 

field of the solid, 

oral and sterile production areas; 

is at 360° available to 

the customer for engineering 

and design, construction, installation 

and assistance services, 

its expertise which always 

puts customer satisfaction 

first, together with, 

CO.RA. creates the application 

tailored and suited to 

individual needs. 

The experience gained in over 

30 years of activity, make the 

company an ideal partner 

who is able to offer a range 

of transversal products, from 

components and fittings for 

the chemical-pharmaceutical 

all the way to solid handling 

plants, ensuring assembly, 

testing, maintenance and assistance. 

CO.RA. offers a vast 

portfolio of products particularly 

specialized in connection 

and interface systems 

between machine A and machine 

B, within the process. 

The production is based on 

the standardization of the 

products but at the same 

time the distinctive factor is 

in the ability to understand 

the needs and specificities 

of the customers and adapt 

or design the CO.RA. product 

able to respond exactly to 

the needs. The staff follows 

the customer and the process 

from the analysis of needs, 

to the installation and testing 

of the product/system up 

to the periodic maintenance. 

The processes of technical 

design, processing, testing 

and certification of the products 

respect the quality procedures, 

the most careful and 

strict certification bodies in 

compliance with the Pharmacopoeia 

directives (FDA). 

The goal is to ensure that 

CO.RA. products contribute 

and guarantee, within the 

chemical, pharmaceutical, to 

the production of reliable and 

quality pharmaceuticals. 


30_37_news achema.indd 30 25/07/22 11:33


State-of-the-art liquid filtration solutions 

Hall 12 - Booth D22 

The Filtration Division of the energy management company Eaton will be 

exhibiting at Achema numerous solutions for the Life Sciences and Industrial 

Processing segments. A special focus will be on the new generation 

of BECO CARBON depth filter sheets containing activated carbon 

and the Simplex 72X pipeline strainer range. 

The upgraded Beco Carbon depth filter sheets containing activated carbon 

offer particularly high adsorption properties for the demanding filtration of 

liquids. Having the activated carbon bonded directly into the filter eliminates 

the need for manual dosing and separation of the otherwise typically 

loose activated carbon and the challenges that go along with it. With 

their strong decolorization abilities and adsorptive removal of undesired 

by-products, along with taste, odor and color correction, they are ideally 

suited for use in the fine chemical, pharmaceutical, cosmetic, food and 

beverage, and biotechnology industries. Beco Carbon depth filter sheets 

are available in the versions ACF 02 with an activated carbon content of 

1,000 g/m² (macroporous) and ACF 07.10 with 420 g/m² activated carbon 

content (meso/macroporous). They are available in all common filter sizes 

and formats as well as stacked disc cartridges and small disposable capsules. 

The product program thus covers 

the requirements from laboratory 

to production scale. 

The new Simplex 72X strainer range 

consists of a total of six standard sizes 

from one to six inches for industrial 

pipelines. It features improved O-ring 

seals and allows removal of solids down to 

40 µm. In particular, they support the protection of industrial plants where 

chemical, petrochemical and water pipelines can be temporarily shut down 

for cleaning or replacement. A duplex solution is also available for continuous 

processes. The improved sealing and surface finish properties comply 

with the Pressure Equipment Directive (PED), EN13445 and AD 2000 

pressure vessel codes. 

In addition to the product highlights Beco Carbon and Simplex 72X, Eaton 

will also be showcasing other filtration solutions for life sciences, such as 

membrane filter cartridges and housings, depth filter media, stacked disc 

cartridges and housings, and filtration systems for laboratory applications. 

 

 

 

 

HQ: Via Rosso Medardo, 16 - 20159 Milano IT 

Factory: Via A. Gramsci, 1 - 26827 Terranova 

dei Passerini (LO) - IT 

www.terranova-instruments.com 

ph: +39 0377 911066 • fax: +39 0377 919156 

terranovainstruments 

terranovainstruments 

30_37_news achema.indd 31 25/07/22 11:33


Continuous Manufacturing to believe in 

Hall 3.0 - 

Booth F49 

IMA Active will have a corner dedicated to Continuous 

Manufacturing, that underpins the improvement of 

pharmaceutical products in terms of potency, effectiveness and 

safety by means of accurate process control. 

IMA Pharma is world leader in 

the design and manufacture of 

automatic machines for the processing 

and packaging of pharmaceutical 

products thanks to 

a high technological profile and 

the ability to offer tailor-made 

solutions to satisfy the most sophisticated 

requests of the market, 

thanks to highly specialised 

divisions: IMA Active (Solid 

Dose Solutions), IMA Life (Aseptic 

Processing & Freeze Drying 

Solutions), IMA Safe (Packaging 

Solutions) and IMA BFB (End of 

Line Solutions). 

At Achema 2022, visitors will 

have the chance to discover 

what’s new from IMA for the 

pharmaceutical industries. 

IMA Active will have a corner 

dedicated to Continuous Manufacturing. 

Continuous Manufacturing 

underpins the improvement 

of pharmaceutical products 

in terms of potency, effectiveness 

and safety by means of 

accurate process control. 

IMA Active have been cultivating 

their own knowledge and are 

ready to welcome the demand 

for innovation, working together 

with companies and stakeholders 

to design the future of pharmaceutical 

manufacturing and 

taking the lead in the future of 

pharmaceutical technologies for 

OSD (Oral Solid Dosage) forms. 

IMA Active’s belief in and knowledge 

of Continuous Manufacturing 

have grown stronger thanks 

to intensive R&D work carried 

out on two fronts. 

A more disruptive front of IMA 

Active R&D consists in the partnership 

with Continuus Pharmaceuticals, 

a spin out of Novartis 

MIT centre, leveraging a novel 

production platform called Integrated 


(ICM). ICM enables seamless 

end-to-end continuous manufacturing 

processes that incorporate 

API formation steps with 

final drug product formulation. 

IMA Active supports ICM in the 

development of EMC (Extrusion 

Moulding Coating Technology) 

to create the final dosage form. 

While on the other R&D front 

IMA Active work on continuous 

processes by revisiting current 

technologies, embracing a concept 

of Continuous Manufacturing 

more closely related to conventional 

solid forms. 

This initiative aims primarily 

to introduce continuous equipment 

into the market that can 

be integrated with conventional 

technologies, even in an existing 

plant, in order to improve 

the production performance. 

Continuous direct compression 

line and continuous direct 

encapsulation 

IMA Active can supply either 

fully integrated lines or unit operations 

to combine with each 

other offering maximum flexibility 

in new or existing plants. 

This initiative quickly provide 


solutions that can be integrated 

with conventional technologies, 

even in existing plants, 

capable to manufacture existing 

drugs with higher performance. 

The tablet press or the capsule 

filler are fed continuously with 

consistent mixture of product, 

from a feeding blending unit 

installed upstream them. The 

whole system is managed by 

Maestro, IMA Active modular orchestration 

layer. The flexibility 

of Maestro makes it easy to integrate 

any kind of unit operation 

so the entire Continuous Manufacturing 

Line can be managed 

as a single system. 

CROMA continuous tablet coating 

equipment is sized to work 

downstream a medium-speed 

tablet press. CROMA is a modular 

unit operation that can be 

configured as a single module or 

in combination of more modules 

either in series or in parallel and 

the product flows continuously 

throughout the modules, with 

no steps. Such combinations allow 

to process all kind of tablets 

at different throughput and 

coating weight gain. The machine 

is fitted with highly innovative 

technologies for process 

monitoring and control, like PAT 

tools and sources of process analytical 

data that can facilitate 

decision-making and follow-up 

action. 

ACCELA CTC 500 continuous 

coater by Thomas Processing 

completes the IMA Active range 

of continuous coating equipment. 

ACCELA CTC 500 is the 

ultimate technology by Thomas 

Processing, who have been 

pioneers in continuous coating 

since 1993. It is designed 

to manage high production 

throughputs in a range of 100- 

1,000 kg/h of large batch sizes 

of tablets to process in continuous 

mode. Advanced design of 

ACCELA CTC 500 provides pharmaceutical 

manufacturers with 

an improved manufacturing process 

to eliminate material waste 

and reprocessing during startup 

and shutdown. Thomas Processing’s 

ACCELA CTC 500 is the only 

coater on the market manufactured 

with an integrated cooling 

chamber that eliminates the 

need for additional cooling systems, 

reducing the footprint of 

the equipment and streamlining 

the coating process. 


30_37_news achema.indd 32 25/07/22 11:33


Innovation and flexibility in packaging 

and processing technologies 

MG2 will show two machines representative of its divisions Packaging 

and Processing. For the first time, the company will host the coexhibitor 

Universal Pack. 

MG2 BliStar 

Hall 3.1 - 

Booth F47 

After months of waiting and postponements, 

MG2 is preparing to fly to Germany. 

The Pianorese company, world 

leader in the design and production 

of capsule fillers and packaging machines, 

will show two machines representative 

of its divisions Packaging 

and Processing: these are BliStar and 

FlexaLAB. 

BliStar is a blistering machine designed 

to optimize the primary packaging 

of capsules and tablets in blisters 

for both pharmaceuticals and 

nutraceuticals. It is characterized by 

both ergonomic design and electronic 

control that guarantee fast size 

change over by recalling a recipe and 

it can manage up to 150 blisters/ 

minute with maximum dimensions of 

mm 90×140. BliStar is a tile that expands 

MG2 proposal, to allow its customers 

to create a complete packaging 

line, starting from the capsule 

fillers to the end-of-line machines. 

FlexaLAB is a capsule filling machine 

specifically designed for R&D laboratories, 

small batches and special 

productions, suitable to dose several 

pharmaceutical oral forms, with production 

speed up to 3.000 capsules/ 

hour. At Achema, FlexaLAB will be 

equipped with two dosing units specially 

designed for trending applications: 

the Microdose unit suitable 

for powder micro-dosages (including 

API without excipients) from 0.5 

mg and the liquid filling unit which 

can manage cold liquids, hot-melt 

liquids and suspensions up to 70°C. 

This is how MG2 introduces itself on 

the German market which has been 

also the scene of a recent success: 

the supporting activity to industrialize 

a pharmaceutical product for inhalation 

purposes, carried out for an 

important CDMO, the Aenova Group. 

The capsule filling machine, which is 

installed in the Münster plant, is a 

Planeta 200 equipped with a powder 

low-dosages unit (from 5 mg to 40 

mg) and the MultiNETT system that 

controls 100% in-process net weight 

of each filled capsule. 

MG2 technology is not the only one 

present on the stand, which also hosts 

the partner Universal Pack, an Italian 

company based in Romagna which 

boasts over 50 years of experience in 

the production of vertical packaging 

machines for single-dose packaging. 

Universal Pack cooperates in the USA 

with MG America, the historic subsidiary 

of MG2. The company will 

show the Alfa Flexi vertical packaging 

machine, able to produce a 

wide range of stick-packs. This machine 

is designed for powders and 

liquids processing, at low and high 

dosage, to guarantee high standards 

of flexibility. This solution is made 

possible thanks to the combination 

of different modular components, 

which allow the company to offer user-friendly 

technology to the market, 

ideal features for those customers 

with easy and fast format change 

needs. The Alfa Flexi vertical packaging 

machine combines minimum dimensions, 

ergonomic and flexibility 

to make the role of the operator as 

Microdose detail 

easy as possible. 

MG2 and Universal Pack are ready 

to welcome visitors to Achema with 

their top-level technological offer, 

an expression of European and especially 

Italian industrial excellence 

in the sector of processing and packaging 

machines for the pharmaceutical 

and nutraceutical fields. 

Alfa Flexi by 

Universal Pack 

Alfa Flexi detail 



30_37_news achema.indd 33 25/07/22 11:33


A solution for the serialisation 

and aggregation in cartons of blisters 

A robotised integrated line for packaging blisters in cartons 

will be presented by Marchesini with labelling machine 

complete with incorporated checkweigher for dynamic 

weighing and control of cartons. 

Hall 3.1 - 

Booth G3 

At Achema, Marchesini Group 

will be presenting a wide selection 

of machines and lines developed 

for the pharmaceutical industry 

with innovative features 

in the areas of Industry 4.0, sustainability, 

safety and product 

traceability. 

In centre stage on stand G3 in 

hall 3.1 will be a state-of-theart 

solution for the packaging, 

serialisation and traceability of 

blister products, developed in 

association with strategic partner 

SEA Vision - a company specialising 

in vision systems. 

Integra 720V, a robotised integrated 

line for packaging blisters 

in cartons, will be presented 

with BL-A525 CW labelling 

machine complete with incorporated 

checkweigher for dynamic 

weighing and control of 

cartons. What makes this line 

innovative is the inclusion on 

board the machine of a new 

technology, unique on the market: 

a complete software package 

that aggregates the blister 

to the carton. 

This is a strategically important 

solution for all contexts where 

blisters are sold, distributed or 

separated from their original 

pack, whether by the end user 

or by other players along the 

distribution chain, such as in 

hospitals, or in pharmacies in 

many countries. Although regulators 

do not yet require the 

serialisation of individual blisters, 

this technology is intended 

to provide suppliers with an 

added opportunity for protecting 

consumers and combating 

the counterfeiting of pharmaceutical 

products, preparing for 

the future and its demands in 

advance. 

The Integra line will be further 

equipped with the Predictive 

Maintenance solution developed 

by the Marchesini Group. 

The data of the sensors installed 

on board the machine (IoT) is 

collected, analysed with the aid 

of Artificial Intelligence (AI) algorithms, 

transformed into information 

useful to the operator 

and displayed by means of a 

dedicated web platform, on display 

at the show. Checking this 

information will enable anomalies 

to be identified and maintenance 

to be scheduled in advance, 

avoiding any failures. 

In addition to this new technology 

for solid products, the Group 

will also be exhibiting two more 

innovative lines for the inspection 

and packaging of products 

in stickpacks. 

First of the two, visitors will 

be able to view a line consisting 

of a CMP Phar.ma inspection 

machine checking 400 vials per 

minute: thanks to innovative inspection 

systems based on Neural 

Networks and Artificial Intelligence 

(AI) technology, the 

new machine upgrades performances, 

maximising flexibility 

and precision. The line is completed 

by an RL-F800 extremely 

high-speed labelling machine 

with a rotary star wheel infeed 

system and rotary roller conveyor, 

designed by the Neri division, 

and a TM3 for bundling vials in 

trays, with counter function. On 

board the line, SEA Vision cameras 

will provide optic control of 

tray contents. 

Secondly a line for packaging 

products in stickpacks, comprising 

a Schmucker MT1300 12-lane 

stick packaging machine, a stacking 

and counting system and an 

MA80 cartoner. Specifically, this 

line is designed to process PPbased 

packaging materials (with 

and without PE) such as 100% 

recyclable plastic monomaterials 

like OPP or BOPP with a metallised 

intermediate layer. 

Stand-alone machines on show 

Three stand-alone machines 

will also be exhibited, including 

FSP05, an automatic solution 

for filling and stoppering 

RTU (Ready to Use) vials, cartridges 

and syringes in nests. 

This machine, produced by the 

Corima division and already 

consolidated on the market, 

is presented with a new filling 

technology using “disposable 

volumetric pumps” developed 

by Neoceram in association 

with Marchesini Group. 

On show will be also a TUR- 

BO-MEK 1000, a vacuum turbo-emulsifier 

for processing 

liquid products, developed by 

Dumek, the Group brand specialising 

in processing solutions 

for pharmaceutical products. The 

machine, designed in accordance 

with hygienic and cleaning 

design guidelines, is extremely 

flexible and is ideal for processing 

a wide range of products, 

since it is equipped with an internal 

turbine and a second turbine 

for the external recycling of 

the product. 

Last but not least, the stand 

will host a solution by Dott. 

Bonapace, a company based in 

Cusano Milanino (Milan) that 

became part of the Marchesini 

Group in 2021. The machine 

displayed will be the IN-CAP 

SE automatic filling machine, 

able to process up to 3,000 

capsules an hour and designed 

to dose various products (such 

as powders, liquids, pellets and 

tablets) into the same capsule, 

with over twenty possible combinations. 


30_37_news achema.indd 34 25/07/22 11:33


Powder wetting and dispersing machines 

Hall 12.0 - Booth C68 

Ystral, the German machine and plant manufacturer 

chooses the topic “Trends and Mega 

Trends in Process Technology” for its trade 

show stand at the Achema 2022. With its 

themed trade show exhibit, the mixing and 

dispersion technology specialist intends to 

promote the exchange between different areas 

of the process industry. “Depending on the 

industry, trends in process technology often 

turn out to be very different for similar processes”, 

says Dr. Hans-Joachim Jacob, Senior 

Expert Process and Applications at ystral. “This 

is often due to the fact that manufacturers do 

not know anything about solutions from other 

industries. For this reason, we would like 

to use our new booth concept to get users 

from different areas of the process industry – 

whether it is paints and varnishes, foodstuffs, 

drugs or cosmetics – to learn from each other, 

and thus gain new inspiration for their day-today 

production.” 

The trends presented at the ystral trade show 

stand include cleaning without cleaning agents, 

clean production processes without biocides or 

preservatives, cold chemistry, possibilities of 

process intensification and the realisation of 

intensive processes outside the tank as well as 

the development from co-grind to slurry manufacturing 

and from batch to inline process. 

“The further development of process technology 

is of course also characterised by mega 

trends such as Smart Factory, digitalisation 

or modularised fabrication”, says ystral’s Process 

Engineer Jacob. “However, the trends in 

mechanical process technology selected by 

us mainly aim at making visitors to the trade 

show aware of possibilities which they did 

not know anything about up to that point 

– and providing them with some eye-opening 

insights.” 

Ystral will show how, against the background 

of these trends, altered process-related requirements 

can be implemented with innovative 

mixing and dispersion technologies. The 

company will present amongst others the inline 

powder wetting and dispersing machine Ystral 

Conti-TDS, as well as the Ystral Jetstream Mixer. 

Furthermore, the mixing and dispersion technology 

specialist will introduce the newly developed 

powder dispersing system Ystral BATT- 

TDS, which reduces the manufacturing times for 

the production of lithium-ion-electrode slurries 

in battery production from currently between 

two and six hours to just a few minutes. 

Hall 11.1 / Booth C15 

Continuous Process Monitoring of 

Ozone, TOC and Conductivity 

AMI Codes-II O 3 

Colorimetric standard method according to DIN 38408-3, 

no sensitivity loss in absence of ozone. 

AMI LineTOC 

Early trend detection without laboratory measurements. 

Automatic System Suitability Test (SST) and calibration 

at minimized maintenance. 

AMU Pharmacon 

AMI LineTOC 

AMI Codes-II O 3 

AMU Pharmacon 

Conductivity transmitter according to USP in a 

standardized design and integrated temperature compensation. 

Swan Analitica Srl ∙ IT-16167 Genova 

www.swaninstruments.ch 

swan@swananalitica.it 

Pharmaceutical Water 



30_37_news achema.indd 35 25/07/22 11:33


A single partner for all pharmaceutical industry needs 

Hall 3.0 - 

Booth D73 

Six companies from Coesia Group present their latest 

innovations in terms of packaging machinery, printing 

and factory automation. 

Coesia, a group of 21 companies 

specialized in innovative industrial 

and packaging solutions, is 

participating at Achema, an international 

trade fair dedicated 

to the process industry with manufacturers 

and service providers 

from over 50 countries presenting 

their products for chemical, 

pharmaceutical and biotech research 

and manufacturing). 

Six companies from the Group - 

FlexLink, GF, HAPA, MGS, Norden 

and Volpak - present their latest 

innovations in terms of packaging 

machinery, printing and factory 

automation, which are aimed 

at improving production efficiency 

and the digitalization of operations, 

as well as reducing the 

ecological footprint of packaging 

for the pharmaceutical sector. 

Coesia offers a complete portfolio 

of solutions and services for customers 

who are facing the new 

market challenges, increasingly 

oriented toward greater sustainability 

and the digitization of processes 

in the Pharma sector. 

In particular, Coesia is progressively 

focusing on digital tools 

and services to optimize the efficiency 

of machines, lines and 

entire factories, and deliver advanced 

support to customers. 

The latest Coesia Digital innovations 

are: 

• OptiMate, Coesia’s new smart 

HMI, developed to expedite operations 

such as format change, 

troubleshooting, maintenance or 

technician training, and to facilitate 

access to guided procedures 

and digital documentation directly 

on the machine. OptiMate 

is installed and visible on Hapa 

and Enflex (a brand of Volpak) 

solutions at the Coesia booth. 

• PerforMate, Coesia’s IIoT platform 

for real-time machine monitoring. 

Working as an entry 

point to many innovative services, 

PerforMate allows improved 

control, enhanced collaboration, 

and performance boost of 

customers’ entire machine pool. 

Sustainability remains one of the 

fundamental pillars of Coesia’s 

strategy. Indeed, the majority 

of the machines on display are 

able to handle sustainable materials, 

such as paper films or mono-materials. 

The Coesia Shelf 

of Sustainable Solutions, present 

at the stand, is dedicated to 

sustainability and eco-sustainable 

packaging offered by the 

Coesia companies in the Pharma 

industry. 

The six Group companies joining 

the exhibition 

Enflex, a Volpak brand, is presenting 

the F-11, a machine 

that manufactures, fills and seals 

flat flexible pouches specifically 

designed for the pharmaceutical 

industry. The F-11 is suitable 

for packaging a wide range of 

products, such as pharmaceutical 

powders, pills, medical devices, 

over-the-counter medicines, 

wipes and swabs. 

The experts at FlexLink, a leading 

company in the field of automated 

manufacturing and material 

flow solutions, are on hand 

to discuss how industrial automation 

can improve high-value 

From 

the left: 

Enflex F11; 

GF AV-E 

inspection 

machine 

pharmaceutical manufacturing 

processes and increase the efficiency 

of medical packaging. 

FlexLink’s X45 conveyor system 

is designed for high throughputs 

that require special attention 

and offers several functions. 

GF, an expert in turnkey solutions 

for the primary packaging 

of injectable drugs in vials, ampoules, 

cartridges, syringes and 

bottles, presents the AV-E inspection 

machine: fully automated 

and developed to treat vials, 

bottles and cartridges filled 

with injectable solutions and lyophilized 

products. It is the ideal 

solution for meeting the requirements 

of GMP (Good Manufacturing 

Practice) and to ensure that 

the products are essentially free 

of foreign particles. 

Hapa showcases two solutions 

that offer printing and inspection 

capabilities integrated on 

the same machine through a 

common workflow. This innovation 

substantially reduces the 

time spent on system integration 

and validation. 

The technicians and experts at 

MGS, a Coesia Company that designs 

and manufactures customized 

and cutting-edge packaging 

solutions in the Life Science sector, 

are available to show customers 

and visitors how to solve 

unique packaging challenges and 

achieve seamless production. 

Norden, a leader in the supply 

of high-performance systems for 

tube filling as well as cartoning, 

offers numerous machine models 

and various technologies to 

meet every production need. 


30_37_news achema.indd 36 25/07/22 11:33 

PUB_P


High potency active 

Active 

Always active support for API 

and HPAPI processes 

GxP inside 

Milano - Vicenza - Latina 

PVS srl 

Process Validation Service 

30_37_news PUB_PVS_CAFFE_230x285.indd achema.indd 37 4 11/07/22 25/07/22 16:06 

11:33


A prominent position 

in the chemical raw materials 

distribution sector 

The site of 

OQEMA Italy 

in Rivanazzano 

Terme, Pavia 


38_40_articolo oqema.indd 38 25/07/22 11:38


OQEMA EVS has was formerly known as Elettrochimica Valle Staffora, 

a company operating since 1930 in the chemical raw materials distribution 

sector. Since 2019, it has expanded its international distribution 

offer in the food, cosmetics, pharmaceutical, rubber and resins, chemical 

industry, water treatment, paint and coatings and livestock sectors. 

OQEMA is an internationally 

active distribution company 

for basic and specialty 

chemicals based in Germany 

since 1922; it is, traditionally 

and conventionally, a medium-sized 

family-run business (the 

"German Mittelstand"). A feature that 

OQEMA is convinced can also bring 

advantages to larger customers, with 

faster decision-making processes that 

support the business better. 

In Italy, OQEMA is based in Lombardy, 

with offices in Assago (MI) and Rivanazzano 

Terme (PV), where the management 

offices, logistics and warehouses 

are located. Here it was formerly 

known as Elettrochimica Valle 

Staffora, a company operating in the 

chemical raw materials distribution 

sector since 1930 and which has been 

working from the very beginning to 

find solutions to improve our quality 

of life and that of future generations. 

The Group's first 3 years in Italy 

Thanks to a team of experienced professionals, 

Elettrochimica Valle Staffora 

gained a prominent position in the 

chemical raw materials distribution sector, 

combining professionalism, quality 

and innovation with its widespread 

presence in various production sectors. 

Since 2019, Elettrochimica Valle Staffora 

has become OQEMA EVS and it has 

expanded its international distribution 

offer in the food, cosmetics, pharmaceutical, 

rubber and resins, chemical 

industry, water treatment, paint and 

coatings and livestock sectors. 

Today, OQEMA is a Group with a turnover 

of more than 1.3 billion Euro, with 

29,000 customers, distributing 14,000 

products throughout Europe and employing 

1,300 people in 45 locations 

in 23 countries. 

The structure 

Whoever tries something completely 

new must be able to constantly break 

with tradition. Never before in the 

history of the company has a member 

of the founding and owner family 

left without being replaced by another 

family member. 

Peter Overlack's departure marks the 

beginning of a new management era: 

the new Executive Board now consists 

of three people none of which 

are members of the Overlack family. 

While this involves a natural and gradual 

detachment from executive leadership 

continuity on the one hand, it 

also represents an opportunity for the 

best people to take the reins and work 

diligently and efficiently, regardless 

of personal disagreements and shareholder 

disputes. 

In any case, Peter Overlack will remain 

quite close to the company, just like his 

family, in his role as a member of the 

Supervisory Board, while, Patrick Barthels 

has become Chief Executive Officer 

of the OQEMA Group on 1 July 2022. 

Hartmut Kunz will remain in charge of 

finance, administration, marketing, legal, 

IT, compliance and digitalisation. 

He has been involved in the complete 

overhaul of the company’s IT solution 

over the last few years and therefore 

still has a lot on his plate. 

Philipp Junge is joining the Executive 

Board as a fresh face. He previously 

worked at Lanxess, where he 

spent the last 14 years and held various 

active leadership roles. The challenge 

of working in a characteristically 

mid-tier environment was a particular 

incentive for him. He has made the 

move to the OQEMA Group and began 

as Chief Operating Officer (COO) on 1 

June 2022. 

The OQEMA Group is divided into HUBs, 

eight in total. Italy is headed by Matthias 

Mirbach as HUB Director of Southern 

Europe, which recently expanded to 

include France, where the OQEMA SAS 

and OROSOLV units operate. 

With this step, the possibilities for synergies 

in the organic, inorganic and spe- 

OQEMA is a Group with a turnover of more 

than 1.3 billion Euro, with 29,000 

customers, distributing 14,000 products 

throughout Europe and employing 

1,300 people in 45 locations in 23 countries 





cialty sectors in France, Spain, Portugal, 

Italy and North Africa have increased. 

The leading figures of OQEMA Italy 

OQEMA EVS's Board recently welcomed 

Renato Quinto, sales, purchasing and 

logistics manager. Renato has years of 

experience in the chemical and plastics 

industry in Group such as Arkema. 

“I have embarked on this new adventure 

driven by the Group's potential. 

I found a stimulating environment in 

a multinational but people-oriented 

context, where attention to customer 

needs and passion for one's work are 

OQEMA’s long experience and resources 

dedicated to processing and distributing 

chemicals for recycling will allow the Group 

to be recognised as a leader in the recovery 

and reuse of a wide range of chemicals 

and energy storage applications 

an important strong point” comments 

Renato Quinto. 

In addition to Quinto, the Board includes 

Chairman Matthias Mirbach and 

Laura Cellerino, Director and CFO. 

“I started working with Elettrochimica 

Valle Staffora and I was able to contribute 

to the integration of the company 

into the OQEMA Group, starting 

from rebranding at the end of 2020, 

and all the way to the implementation 

of policies and strategy. Working 

with the talented and skilful people 

who were already in the company has 

led to excellent results over the past 

two years and I am convinced that we 

have laid down a solid foundation for 

our growth” says Laura Cellerino. 

The Group's Vision for the short term 

Within 2027, OQEMA aims to consolidate 

its position in the distribution 

sector and grow, in order to reach a 

turnover of 2 billion Euro, with 2,000- 

3,000 employees and with a widespread 

coverage all over Europe. In the 

long term, OQEMA aims to become one 

of the top five-ten chemical distribution 

companies in the world. 

How will it be possible to achieve these 

goals? Innovation, flexibility and excellent 

service to constantly increase customer 

satisfaction. Flexibility, focus on 

service, readiness and speed: in aiming 

for growth, OQEMA wants to consciously 

create or maintain structures that allows 

the Group to quickly develop customised 

solutions for its customers. 

“We will make sure that the increasing 

development of our expanding business 

does not make our work processes 

become too rigid or regulated. We believe 

that employees should always be 

able to make decisions on site for our 

customers. We have an invisible ‘flexibility 

watchman’ who keeps an eye on 

us and tells us if we are becoming too 

slow or too complicated” comments 

the OQEMA Group Board. 

A century of corporate history 

In the summer of 2022, the OQEMA 

Group will be celebrating its 100th 

birthday, giving us the opportunity to 

take stock of this first century and giving 

us another reason to look towards 

the future. How can we become even 

more sustainable? Which internal and 

external values must be strengthened 

in the coming decades? 

The Group will continue to plant seeds 

to watch them grow and, with the motto 

“Planting Seeds”, has defined six 

fundamental areas that are reflected 

in the anniversary campaign: People, 

Presence, Product, Planet, Performance 

and Planting. 

Committed and motivated employees 

have always been an important success 

factor (People) for OQEMA, to be 

supported to actively realise their potential 

with development plans, focusing 

on diversity and promoting mental 

and physical health. 

The Group's headquarters in the various 

European countries (Presence) 

must be as climate-friendly as possible 

(e.g. completely zero-emission 

warehouse in Austria). 

In the Product area, efforts are being 

made to review and optimise 

the product portfolio in the direction 

of greener, more environmentally 

friendly and bio-based raw materials. 

In Germany, there is already a 

strong bio-based portfolio in the Flavour 

and Fragrance division. 

Reuse, recycle, reduce: the three ‘R’ of 

sustainability are assigned to the Planet 

aspect. The circular economy within 

chemicals will play an important role 

in achieving the sustainability goals. 

OQEMA's long experience and resources 

dedicated to processing and distributing 

chemicals for recycling will allow 

the Group to be recognised as a leader 

in the recovery and reuse of a wide 

range of chemicals and energy storage 

applications. 

In order to develop in the distribution 

market, it is necessary to recognise 

growth opportunities and exploit 

them consistently (Performance). This 

is what OQEMA is able to do. Another 

highly competitive factor is profitability, 

which provides the necessary 

funds for investments and ensures the 

strength to constantly put customer 

needs at the centre of the company's 

actions. 

Last but not least, the heart of the 

100-year project: Planting. A greener 

and more sustainable world can be 

achieved not only by adapting products 

and optimising supply chains and 

warehouses, but also by simply planting 

trees. In 2021, the Overlack family 

acquired the Lappen nursery, which 

they have now relaunched under the 

name Baum & Bonheur. 

And with this in mind, for the OQEMA 

Group's 100th anniversary, mighty 

trees will be planted at each of the 

Group's locations to make a significant 

contribution to climate protection. 


38_40_articolo oqema.indd 40 25/07/22 11:38 

advS4S

S4 

S 

TECHNOLOGICAL 

KNOW-HOW 

IN OUR DNA 

FOR YOUR ENVIRONMENTS 

OF PRODUCTION AND CONTROL 

WE OPTIMIZE THE SPACES 

AND THE TECHNOLOGY 

WE KNOW HOW TO BUILD WHAT WE IMAGINE 

ENGINEERING • CONSTRUCTION • COMMISSIONING • VALIDATION 

S4S S.R.L. 

Via Celotti n°8 - 20814 - VaReDo (MB) 

tel.1: +39 03621900102 tel.2: +39 0289080326 

info@s4ssRl.it www.s4ssRl.it 

advS4S_2022_def.indd 2 20/06/22 17:45 



-70% greenhouse gas 

emissions in the last decade 

In the past decade, RadiciGroup slashed greenhouse gas emissions by 70%. 

The next target is -80% by 2030. Radici Chimica Novara plays a key role 

in reducing Group environmental impact. 

Nitrogen oxide 

abatement plant 

at Radici 

Chimica Novara 

Setting concrete environmental 

sustainability objectives 

for abating direct greenhouse 

gas emissions and leveraging 

investments and state-of-theart 

technology. This is the approach 

that has always guided world leading 

manufacturer RadiciGroup in operating 

its businesses with a wide range of 

products: chemical intermediates, polyamide 

polymers, high performance engineering 

polymers and advanced textile 

solutions. 

RadiciGroup’s strategy has paid off, allowing 

the Group to reach ambitious 

goals: between 2011 and 2020, overall 

Group greenhouse gas emissions were 

cut by 70%, falling from about 700,000 

metric tons per year of CO 2 

equivalent 

to 200,000 metric tons. 

These results were largely achieved 

through the action implemented by 

the Group’s Specialty Chemicals Business 

Area at its plants in Novara, Italy, 

and in Germany, which are the heart of 

RadiciGroup’s chemicals business. Here 

the Group produces an essential intermediate 

for synthesizing polyamide 66, 

adipic acid, whose production process 

releases nitrous oxide as a by-product. 

Nitrous oxide in itself is not particularly 

problematic (in fact, it is used in the 

medical sector as an anaesthetic and 

in the food industry as a spray propellant, 

in cans of whipped cream, for instance), 

but, if it is released into the atmosphere, 

it has a much higher greenhouse 

gas effect than carbon dioxide. 

At the Radici Chimica site in Novara, 

a multiyear investment budget of over 

EUR 10 million was dedicated to lowering 

these emissions through three important 

undertakings: in 2004, putting 

into operation a three catalyst bed reactor, 

designed and patented by the 


42_43_art_radici.indd 42 25/07/22 11:45


Here beside: 

production 

of Polyamide 66; 

On the left: 

demineralised 

water plant 

company, to decompose nitrous oxide 

into nitrogen and oxygen, the two elements 

it is composed of, thus making 

it innocuous for the atmosphere; 

in 2013, installing an EnviNOx plant to 

decrease the release of nitrous oxide 

formed in the production of nitric acid, 

and, in 2021, a further improvement in 

the emissions abatement system associated 

with nitric acid production. 

Since activating the last plant just 9 

months ago, more than 35,000 metric 

tons of CO 2 

equivalent have been cut. 

All the above-mentioned actions have 

enabled Radici Chimica Novara to record 

a nitrous oxide emissions level less 

than 10 ppm, a value close to zero. 

“We are the only Italian manufacturer of 

adipic acid, a basic chemical intermediate 

for numerous industries, as well 

as polyamide 66, our own sector. The 

investments we have made to improve 

the environmental performance of the 

adipic acid production process have allowed 

us to achieve significant results 

and make our business increasingly 

more sustainable,” Maurizio Radici, 

vice president and COO of RadiciGroup, 

stated. “We decided to implement initiatives 

for emissions abatement long before 

it was required by law. As a matter 

of fact, we started studying the available 

technologies at the end of the 

1990s and advocated for setting up 

the European Emission Trading System 

(ETS) in the Italian chemical industry in 

2011, two years before it became law.” 

Furthermore, in Germany, in 2001, 

RadiciGroup built from scratch an adipic 

acid plant that uses Best Available 

Techniques, including an advanced 

thermal abatement system for nitrous 

oxide. Additionally, by the end of 2022, 

an EnviNOx plant is scheduled to be in 

operation, so as to bring the plant’s direct 

greenhouse gas emissions down to 

zero, by reducing nitrous oxide emissions 

associated with nitric acid production. 

“We are convinced that our companies 

will grow only if they stay in harmony 

with all their stakeholders, Angelo Radici, 

president of RadiciGroup, emphasized. 

“As regards minimizing environmental 

impact, we will continue to invest from 

the perspective of continuous improvement, 

so that our recent installations 

in the Specialty Chemicals business area 

will enable us to further abate total 

Group greenhouse gas emissions and by 

2030 arrive at a reduction of around 

80% compared to 2011. Moreover, concerning 

energy, on top of an innovative 

trigeneration plant, all our Bergamo 

sites use self-produced renewable 

energy or draw electricity from the grid, 

with the ambitious objective of 100% 

self-produced renewable source energy. 

Radici Chimica Novara is directly connected 

to a high-efficiency cogeneration 

plant that runs the site and fully 

covers its energy needs.” 

President Radici continued: “Besides 

our commitment to energy issues, we 

invest in innovation and the development 

of new recycling and circular 

economy projects, trying to take tangible 

action towards a sustainable future 

for our companies and the communities 

where we operate.” 

Other significant investments in emissions 

abatement have been carried out 

at the RadiciFil site in Casnigo (BG) 

and at Radici Yarn in Villa d’Ogna (BG). 

RadiciFil installed a thermocompression 

system that slashes steam consumption 

by the production plant, while Radici 

Yarn set up a trigeneration plant that 

uses a high-efficiency system to produce 

not only electricity and steam, but 

also cold water needed for the production 

processes, resulting in a drop in 

water usage of 30% in 2021. 

From the left: 

Maurizio, 

Angelo and 

Paolo Radici 



42_43_art_radici.indd 43 26/07/22 10:54

Validation 

Consulting GMP, training and 

auditing: the new Ellab services 

The journey towards a more efficient process and reduced 

operation costs starts here. 

Ellab provides world-leading 

validation, monitoring and calibration 

solutions and services, 

as well as GMP consulting, to life 

science and food manufacturing 

companies. The company serves 

both small and large companies 

within the Life Science and Food 

industries and have solutions for 

almost all applications such as 

sterilization, freeze drying, environmental 

chamber testing, 

depyrogenation, warehouse 

mapping, pasteurization, controlled 

temperature units (CTU) 

and many more. 

Ellab develops unique and innovative 

solutions based on input 

from close interactions and dialogues 

with customers. The goal 

is to help the customers overcome 

challenges and increase 

their productivity by providing 

reliable and efficient solutions. 

The main services can be split 

up into the following categories: 

- Commissioning, Qualification 

and Validation Services 

(CQV), for on-site projects, 

temperature mapping qualifications 

and commissioning 

tasks. The qualification and 

validation teams of Ellab aim to 

assist you with meeting industry 

requirements and guidelines 

to ensure safe and high-quality 

products. The company covers a 

wide array of applications and 

tasks, from all kinds of temperature 

mapping, IQ, OQ and PQ’s 

to alarm testing and shelf mapping 

– just to name a few. Ellab’s 

highly trained technicians are 

well versed in the requirements 

from government agencies such 

as the FDA, EU and ICH. To reduce 

the turnaround time, Ellab 

works with its efficient reporting 

tools, but also accepts and 

works with whatever report, 

protocol and/or SOP templates 

that customers desire. Allowing 

Ellab to draft documentation designed 

specifically for customer’s 

project and procedures. 

- Consulting and Engineering 

Services, for sparring, project 

management and support. 

Ellab’s consulting teams have the 

vast experience required to advise 

the customer on its projects 

and processes. All Ellab’s consultants 

are GMP experts capable 

of increasing operation reliability 

and ensuring compliance 

while decreasing costs. Ellab 

thrives in supporting customer 

development and production, as 

well as managing its projects to 

eliminate deviations and bottlenecks. 

With Ellab as consulting 

partner, the user gets access to 

experts with crucial knowledge 

of: implementing cost reduction 

measures, implementing 

preventative measures, setting 

up and executing master plans, 

managing project scopes, timescales 

and tasks, providing commissioning, 

validation or qualification 

reports as proof of completion, 

conducting a wide array 

of relevant studies, audits, assessments 

and tests, performing 

data analysis and error-checks, 

and much more. 

- Field Calibration Services, for 

equipment calibrations and 

adjustments on location. 

Ellab’s field calibration services 

are perfect for whenever off-site 

calibrations stop being an option. 

This could be due to the 

hassle of transporting sensitive 

measuring equipment or due to 

sensors being locked in crucial 

processes – either way, Ellab’s 

calibration technicians have 

the solution. With the portable 

equipment, the company can 

see to customer’s calibrations 

anywhere, anytime. Ellab exclusively 

uses high-end calibration 

hardware and software to ensure 

that the calibrations and adjustments 

are accurate and well documented. 

All Ellab’s calibrations 

come with reproducible, traceable 

and compliant certificates 

that are saved to company’s 

cloud and can be printed whenever 

necessary. Field Calibrations 

drastically reduces downtime 

for measuring instruments 

and eliminates shipping costs 

and risks. All Ellab’s calibration 

equipment is traceable to AC- 

CREDIA to ensure the traceability 

to measurement standards 

of physical quantities including 

temperature, humidity relative, 

CO 2 

, dew point, pressure 

and electrical quantities. 

-Training is also a pillar of 

Ellab’s business: the company 

offers specialized training 

courses within Ellab Academy 

both in headquarters and online 

and gives the customers 

the opportunity to agree on the 

training course best suited to 

their needs. 

For further information visit the 

website www.ellab.com. 

C 

M 

Y 

CM 

MY 

CY 

CMY 

K 


44_44_news ellab.indd 44 25/07/22 11:54 

robusch

ai165727183514_robuschi_232X385.pdf 1 08/07/22 11:17 

C 

M 

Y 

CM 

MY 

CY 

CMY 

K 

robuschi.indd 44_44_news ellab.indd 1 45 08/07/22 25/07/22 11:19 

11:54

Safety 

Systems for controlled 

atmosphere environments 

S4S designs and develops clean room and production area systems, 

offering industry a high level of skill and flexibility. 

Cart for 

LAF area 

vironmental and energy control-related 

issues. The meaningful know-how in the 

pharma and chemical fields, today extending 

also to the food and electronic 

fields, top availability towards the customer 

in all of the planning steps, the 

capability of meeting the needs ensuring 

the best possible results are the keys 

to the success of S4S srl, a company 

dealing with the development of controlled 

atmosphere systems designed for 

Flexibility, full availability towards 

the client in all phases of 

the project, top work development, 

cost transparency, practicality 

and professionalism are 

the ingredients that made S4S (www. 

s4ssrl.it) a company standing out for 

the designing and building of systems 

for controlled atmosphere environments 

designed for production areas. 

Today the company is focusing on enclean 

rooms and production areas, as 

well as for “turnkey areas”. The company 

works in the name of enthusiasm, in 

a dynamic and constructing work environment, 

often facing highly customized 

and challenging projects. 

Process and needs within 

the production area 

The development of an environmental 

monitoring plan represents one of 

pharmaceutical companies’ most complex 

activities. Generally, the "design" 

of the activities is entrusted, by procedure 

or internal management, to a single 

professional often as QA or QC. Over 

time, it has been understood how important 

this role is and therefore different 

figures have been involved such 

as engineers and production managers. 

Building an environmental monitoring 

plan means first of all knowing 

the classified environments, the machinery 

and materials present inside, 

the air flows, the external and internal 

flows of material and personnel as 

well as the processes. 

Environmental monitoring is the activity 

that more than others requires a 

transversal commitment, in which S4S 

know-how and skill become fundamental, 

always acting as a partner within 

companies. All laminar flow hoods operate 

on the principle of low turbulence 

forced air flow. Using this principle, a 

stream of air is introduced horizontally 

or vertically along the bench’s entire 


46_47_articolo s4s.indd 46 25/07/22 11:50

Safety 

work area. During this procedure, ambient 

air is introduced into the work area 

as a laminar flow stream and flows horizontally 

or vertically for suspended substances 

with top performance. 

This air stream captures the particles 

directly from the source and transfers 

them without backflow away from the 

cleanroom via the air exhaust duct. 

The choice of vertical or horizontal 

flow should be based on the amount 

and geometry of the items located in 

the work area. 

The analysis of the surrounding environment 

and air flows is key for contamination 

control. For this reason, 

S4S, before the machines are put into 

operation, offers a control service inside 

your premises, to better optimize 

the air flows and the control of contamination, 

thanks to a technique that 

analyzes the air flow and its power. 

Laminar flow hoods avoid particle contamination 

in the filling or packaging 

product operations. Laminar flow 

hoods are installed on existing production 

lines. Vertical flow modules can 

be mounted on mobile structures and 

moved from one area to another. The 

lateral conduction of the clean air flow 

and the protection of the work area is 

achieved by means of PVC curtains or 

side panels. 

The story of a continuous growth 

In 2011, the company’s year of foundation, 

the idea was to create a firm that, 

taking advantage from previous and diversified 

experiences in the engineering 

field in the design for third parties 

and in the validations in the pharmaceutical 

world, could expand the company’s 

know-how. 

Marco Pizzi, the company’s managing 

director, tells us how they came into 

play with the desire to expand their 

skills to pursue continuous improvement. 

Through a continuous exchange 

of know-how, resulting from an open 

and constructive relationship, encour- 

aging collaborations and feedbacks, 

they grew up and developed new skills. 

An increasingly creative, reactive and 

flexible teamwork was built up. The 

large, very bright, colorful and welcoming 

work spaces of the headquarters immediately 

convey their way of interfacing 

and tackling each new project. Enthusiasm, 

opening, listening skills, 

availability, flexibility as well as a solid 

expertise grown on field, make S4S an 

ideal partner for the pharma industry. 

HVAC (Heating Ventilation 

e Air Conditioning) systems 

S4S deals with the construction of 

machines for contamination control, 

for pharmaceutical environments, air 

showers for personnel and materials 

and offers a whole series of related services 

such as design, planning, basic 

and detailed engineering, concept engineering, 

construction and commissioning, 

equipment, validation, requalification 

of machines and environments. 

S4S team is ready to work to 

offer turnkey solutions as a single a reliable 

provider, taking the responsibility 

and control of the order in bulk, as 

well as dealing only with one or more 

parts of it. From design to production 

phase, from installation to validation, 

S4S is ready to listen, analyze and design 

the right solution. The company 

follows all stages of the work, actually 

behaving as if they were a department 

within the client company, and this allows 

to anticipate critical issues by implementing 

a precise and timely problem 

solving strategy. Often, there are 

questions, doubts, needs from the customer, 

even during construction, which 

are faced through an open dialogue and 

constructive discussion aimed at satisfying 

the request and identifying, when 

necessary, the best possible solution. 

Dealing with a competent team capable 

of solving problems not previously 

addressed makes the difference. 

It is a winning and loyal approach, testified 

by the trust of customers who 

have kept working with the group for a 

long time; the relationship with them 

does not end with the completion of 

the work. We boast relationships with 

long-standing customers who return 

for subsequent projects as a result 

of past positive experiences. Quality 

is fundamental in S4S work: it means 

meeting all requirements, ensuring top 

results not just in terms of construction 

and development goals but even 

in terms of economic outcome, offering 

transparency in costs. The project 

is followed step by step, the verification 

is addressed through internal 

procedures at all stages of construction 

and completed during installation 

with inspections and validations of the 

equipment installed, the customer is 

never forgotten. 

The goal remains to continue a path 

of growth, focusing on continuous 

change following requirements, developing 

new skills. This enables to come 

as a cutting-edge company able to anticipate 

future needs in different and 

always new areas. By the way, S4S is 

constantly looking for new professional 

figures to be included in its staff, 

young people capable of integrating into 

the corporate operational fabric and 

at the same time contributing to corporate 

growth with innovative proposals 

and ideas. 

 

Down cross 

hood for 

a sampling 

department 



46_47_articolo s4s.indd 47 25/07/22 11:50

Safety 

A trusted supplier to India’s 

pharmaceutical industry 

Piller, as a supplier of power protection equipment, is 

rapidly expanding its client base in India’s booming 

Pharmaceutical manufacturing sector. 

Piller Power Systems, the global 

sustainable power technology 

infrastructure supplier, is rapidly 

expanding its client base in 

India’s booming Pharmaceutical 

manufacturing sector. 

As an established trusted partner 

and supplier of power protection 

equipment to the pharmaceutical 

sector, Piller clients 

include top ten companies in 

the India pharma industry. 

Both domestic and international 

firms with manufacturing capacity 

in India rely on Piller power 

conditioning, UPS protection 

with battery backed and kinetic 

energy storage solutions which 

are configured for specific applications 

in pharma manufacturing. 

Shailendra S Bais, Piller India 

Director, says: “India is known 

as the world’s pharmacy and 

forecasts for manufacturing 

growth prove it. India’s domestic 

pharmaceutical market value 

is expected to reach US$42 

billion in 2021, likely to reach 

US$65 billion by 2024 and forecast 

to expand to US$120-130 

billion by 2030. Piller focuses 

on establishing long term partnerships 

because it understands 

that building a facility and providing 

vital utility infrastructure 

for pharmaceutical manufacturing 

represents a company’s single 

biggest cost and is heavily 

regulated from the outset.” 

The number of deployments of 

Piller’s latest UB-V electronically 

coupled UPS at Pharmaceutical 

manufacturing 

sites in India is growing. 

The UB-V Series, 

built on the renowned 

reliability of UNIBLOCK, 

is a highly flexible electrically 

coupled UPS system. 

The UB-V provides 

from 1MW to 3.24 MW 

of UPS protection in one 

single-module. UB-V UPS 

operates equally well at 

low and medium voltage. 

The growth of international 

Indian players such as Zydus 

Cadila, Cadila Healthcare and 

Sun Pharmaceuticals, Alembic 

Schott Glass sets alongside big 

investments in new manufacturing 

capacity by the global pharmaceutical 

giants such as Pfizer, 

GSK, Sanofi, Abbott Laboratories, 

Merck and Roche. 

“Drug manufacturing in India 

is undergoing rapid expansion. 

Domestic and international 

firms with manufacturing capacity 

in India use Piller rotary 

power generation, back up, 

battery backed and kinetic energy 

storage solutions,” said Bais. 

Inside India’s booming pharmaceutical 

base the stakes 

could not be higher. Already 

the world’s largest producer 

of generic drugs and maker of 

half the world’s vaccines, India 

has 3,000 drug companies and 

10,500 manufacturing units. 

India is already the largest provider 

of generic drugs globally 

and forecasts point to major 

expansion in manufacturing 

base capacity. The Indian pharmaceutical 

sector supplies over 

50% of global demand for various 

vaccines, 40% of generic demand 

in the US and 25% of all 

medicine in the UK. Globally, India 

ranks 3rd in terms of pharmaceutical 

production by volume 

and 14th by value. 

India’s new pharmaceutical production 

capacity can rely on 

clean, stable and conditioned 

power provided by Piller’s scalable, 

flexible power infrastructure. 

More than 7000 kinetic energy 

storage devices and over 6000 

high power UPS units installed 

in the world 

Piller was founded in Hamburg, 

Germany in 1909 by engineer 

Anton Piller. Employing around 

1000 people worldwide, Piller is 

headquartered in Osterode, near 

Hanover, Germany, with subsidiaries 

across Europe, America, 

Asia and Australia. Piller occupies 

a unique position, being 

the only company to produce 

both types of electrically coupled 

UPS technologies and with 

kinetic energy storage or battery 

options. The company also 

manufactures aircraft ground 

power units, 50/60Hz frequency 

converters, static transfer 

switches and specialist marine 

generators. With more than 

7000 kinetic energy storage devices 

and over 6000 high power 

UPS units installed, Piller has 

more than 300 service personnel 

taking care of clients across 24 

countries. The Piller group is a 

wholly owned subsidiary of the 

multi-disciplined global UK engineering 

and industrial group, 

Langley Holdings Plc. In 2016, 

Piller acquired Active Power 

Inc., the flywheel energy storage 

specialist. 


48_49_news safety.indd 48 25/07/22 11:56 

ICF232

#FaravelliPharmaDivision 

APIs? 

NOW WE CAN! 

BEHIND 

GREAT 

SATISFACTION 

ARE ALWAYS 

GREAT 

RAW 

MATERIALS 

AGENTI FILMANTI - DISGREGANTI - LUBRIFICANTI - GLIDANTI 

- LEGANTI - DILUENTI - OPACIZZANTI - AMIDI E DERIVATI - 

POLIALCOLI - ZUCCHERI - DOLCIFICANTI - VISCOSIZZANTI - 

CONSERVANTI - CORRETTORI DI PH - ANTIAGGLOMERANTI 

- PRINCIPI ATTIVI - PLASTICIZZANTI 

Gli eccipienti e le materie prime distribuite da Faravelli 

ti aiutano a raggiungere la formulazione farmaceutica 

perfetta, proprio quella che stai cercando: funzionale, 

 

 

“Accompagniamo con competenza globale e sensibilità locale i nostri partner verso scelte innovative, per formulare il futuro 

 

VIA MEDARDO ROSSO, 8 - 20159 MILANO - WWW.FARAVELLI.IT - PHARMA@FARAVELLI.IT 

48_49_news ICF232x285 safety.indd new.indd 1 49 25/07/22 07/02/22 11:56 

15:08

Machines 

Mixing technology, 

a very important support 

in the pharma process 

Nuova Guseo has specialized in the design and manufacture of fixed 

body mixers, generally made from a stationary container, with variable 

geometric shape within which the content is moved from rotating parts, 

the mixing elements. 

by Gherardo Marchini, Export Manager, Nuova Guseo 

Horizontal mixer 

model MG 5 RB 

Nuova Guseo has established 

itself over the 

years by designing and 

manufacturing plants and 

equipment for fine and ex- 

tra fine grinding, mixing systems, 

devices for solids handling, containment 

systems for the treatment 

of highly active products. 

Today the company is a reliable 

point of reference in the field of solid 

handling and containment, mainly 

for the chemical, pharmaceutical, 

food and cosmetic sectors. 

Detail of the 

ribbon agitator 

Mixing process 

From the theoretical point of view 

the mixing can be defined as an operation 

that allows to obtain homogeneity 

in a polyphase system 

(ex., dust compounds, emulsions, 

suspensions). the mixing can be 

applied to systems solids (powders) 

or liquids (to obtain solutions, 

emulsions, suspensions). 

The result of a mixing process depends 

on variables related to the 


50_52_ART NUOVA GUSEO.indd 50 25/07/22 12:03

Machines 

substances to be mixed, 

from the characteristics 

of the mixer used and the 

mixing conditions. 

Regarding the characteristics 

of the substances 

(density of powders, form 

of particles, humidity, friability, 

flowability, the characteristics of 

mixers (type of mixer, dimensions 

and shape of the mixer, constructive 

characteristics), the mixing 

conditions (order of adding 

substances, speed and time of 

agitation, volume occupied by 

powders), there are different 

types of mixers that can group 

into two categories: 1) fixed body 

mixers rotating; 2) body mixers. 

Nuova Guseo has specialized in 

the design and manufacture of 

fixed body mixers, generally 

made from a stationary 

container, with variable 

geometric shape 

within which the content is moved 

from rotating parts, the mixing elements. 

These configurations guarantee a 

good mixing, ease of loading and 

unloading, and possibility of mixing 

powders and liquid additives. 

The main types of fixed body mixers 

are horizontal mixers and vertical 

mixers. 

Vertical mixer 

model MG VP 03 

Horizontal mixers 

Horizontal mixers are widely used for 

several applications in mining, foodstuff, 

chemical and pharmaceutical 

industries. The series MG RB consist 

of a U-shaped horizontal tank 

flanged above the lid, equipped with 

Single shaft ribbon screw 

loading and inspection doors, with 

single shaft ribbon screw and are 

configured for batch-type mixing. 

Mixing takes place by means of a 

ribbon agitator that causes product 

to move following crossed lines, 

conveying it to the centre of the 

containment tank to facilitate its 

unloading, obtaining high quality 

mixtures and maintaining the physical 

properties of the product. 

Due to the proven effectiveness 

of the mixing action, this equipment 

guarantee a reduced overall 

height and an easy maintenance 

and cleaning activity, thanks to 

the total opening of the lid. above 

the mixing tank. 

In the lower part there is the discharge 

mouth with a pneumatically 

operated pad valve to avoid 

dead spots of unmixed material. 

The RB mixers series can be manufactured 

in the single or double 

shaft version and with usefull volumes 

up to 10,000 liters. 

By adding a “V” shaped hopper, series 

MG TS, it is possible to work 

continuously avoiding discharging 

intervals. 

The horizontal mixers can also be 

implemented with product transfer 

devices at loading and unloading 

and can be easily integrated 

into complete process lines. 

Detail of nozzle 

for liquid 

additives in 

vertical mixer 




Machines 

Vertical Vacuum 

Dryer Model MG 

1 VP/V 

Vertical mixers 

The vertical mixers, series MG VP, 

consist in an upper cover, suitable 

to support the drive unit, flanged 

to the upper part. On the upper 

cover are allowed at least the 

charging and inspection doors, 

this one protected by limit switch 

that does not allow starting when 

door is opened. 

Conical-shaped body in rugged construction 

at the bottom of which 

is placed the discharging mouth 

equipped with discharging valve. 

These mixers are widely used es- 

pecially in the chemical-pharmaceutical 

field, and are characterized 

by the total discharge of the 

processing batch from the bottom 

of the mixing tank. The simultaneous 

motion of suitable transmissions 

allows the agitator to perform 

two movements: to rotate on 

its own axis and to orbit along the 

inner conical vessel wall. 

In this way the agitator, which 

generally consists in a worm screw, 

conveys product from bottom to 

the top and creates a horizontal 

motion flow. 

Besides, the conical shape of the 

mixing vessel allows to obtain a 

different motion speed of particles 

which depends on their distance 

from the bottom where particles 

moves more speedily. 

Vertical mixer grants particular 

advantages: 

• low power consumption because 

the mixing screw does not act on 

the whole product simultaneously; 

• dust seals not immersed into the 

product; 

• minimum heating of substances; 

• soft mixing action; 

• total emptying without product 

retention; 

• easy to be thoroughly cleaned. 

In relation to the volume of the 

mixer and the application field, 

two different configurations are 

available: with mixing reel without 

bottom support (up to a useful 

capacity of 2000 liters) and with 

a reel supported on the bottom 

(from 1000 liters up to 7000 liters 

useful capacity). 

The vertical mixers can be implemented 

in various ways with special 

washing devices, nozzles for 

introducing liquid additives, with 

product transfer devices at loading 

and unloading, bagging and weighing 

systems and can be easily integrated 

into complete process lines. 

Similar to the series VP, the series 

VPS enables the best ratio of overall 

dimensions/loading volume 

thanks to their truncated-conical 

shaped body. 

A shaft on which a conical spiral is 

applied causes mixing movement. 

The spiral brushes the inner walls 

of the vessel and conveys product 

from bottom to the top. 

Integral with the same shaft a second 

central spiral conveys product 

from the top to the bottom intensifying 

mixing and favouring necessary 

times reduction. 

The slow movement of the mixing 

paddle, completely driven from the 

vessel outside, makes this mixer 

suitable for treatment of fragile 

and heat sensitive products. 

The VPS model can be also used for 

treatment of dry product (both in 

powders and in granules), wet or 

sticky materials, as well as low or 

medium viscosity liquids. 

The vertical mixer can be also configured 

for vacuum drying processes 

series VP/ V, they are designed 

and manufactured for the 

treatment of substances with solvents 

or water, combining the action 

of mixing with that of drying, 

For this purpose, the vertical 

dryer is equipped with an insulated 

filter, heating/cooling 

jacket, vacuum-resistant product 

discharge valve and are configured 

to be integrated into a special 

process line: the unit has to 

be implemented with heating/ 

cooling group, pre-condensation 

group, vacuum pump, post condensation-group. 

For use in classified areas (with 

the presence of hazardous gas 

and/or dust mixtures) the equipment 

is manufactured in compliance 

with the 2014/34 EU Directive 

(ATEX). 

 



Experience 

responsibility 

La via per il successo 

di ogni progetto. 

Conceptual Design 

Basic Engineering 

Detail Engineering 

Project Management 

Construction Management 

Qualifica secondo cGMP 

Procurement 

VTU Engineering Italia Srl 

office.italia@vtu.com 

Via G. di Vittorio n. 16 

39100 Bolzano (BZ) 

Torre Pontina, Via Ufente 20/22 

04100 Latina (LT) 

Viale T. Edison 110 

20099 Sesto San Giovanni (MI) 

Via della Vittoria 90/C 

30035 Mirano (VE) 

www.vtu.com 

Italia | Austria | Germania | Svizzera | Romania | Poland | Belgio 


Components 

Filtration Systems for life 

science 

BEA Technologies offers solutions for the microfiltration 

of liquids and compressed gases dedicated 

to the specific needs of the life science industries: 

Pharmaceutical, Medical and Cosmetic. 

Pharmaceutical companies and 

those involved in life science 

have gone beyond traditional 

business models and are operating 

at worldwide scale nowadays. 

The challenges for the production 

of new medicines and 

active substances are requiring 

increased research and more 

strict cooperation with suppliers 

to design and realize new production 

lines and more flexible 

and efficient new equipment. 

BEA Technologies is aware of 

these new demands and put its 

knowledge at disposal to reach 

the quality and safety levels required 

by current regulations. 

The filtration technologies proposed 

by the company are finalized 

to reach the best Quality – 

price rate for sterilization and 

clarifications of products, active 

substances for pharmaceutical 

use and utilities. 

BEA Technologies offers solutions 

for the microfiltration of 

liquids and compressed gases 

dedicated to the specific needs 

of the life science industries: 

Pharmaceutical, Medical and 

Cosmetic. 

The expertise in typical applications 

such as fermentation, 

sterile filtration of liquids, filtration 

for injectables, filtration 

of process fluids and gelatins 

has allowed the development 

of products with specific 

performances tailored to needs 

of industry and laboratory services 

and a highly professional 

technical assistance. 

Each product is the result of constant 

technological research, of 

the careful selection of materials, 

of a controlled production 

process, and it is verified and 

accepted after specific tests. 

BEA Technologies is organized 

to provide: complete traceability 

of product; validation guides 

for each filter element; compliance 

with USP-class VI, USP water 

for injection; wide range of 

filtering membranes PES, N66, 

PVDF e PTFE; interchangeable 

configurations and End- 

Caps; customization of filters 

and housing, guarantee of high 

quality as the Production process 

is entirely Made in Italy. 

Applications for high 

potent API 

An innovative line of filtering 

systems designed to assure 

safety in High Potent API 

(HPAPI) applications. The system 

is made to achieve double 

containment, with the filter element 

contained in a capsule, 

enclosed in a second steel or 

plastic housing. A practical and 

effective solution to replace insulators. 

Complete line of capsules and 

filter elements 

BEA Technologies offers a complete 

line of filter elements for 

all the needs of the Life Science 

industry, which includes 

the main types of pre-filters 

and innovative filter elements 

in nano- fibers, available cartridge 

and with the most widely 

used interchangeable GND caps. 

The filter elements are provided 

with the necessary documentation: 

validation guides, to complete 

the Regulatory Files and 

marked with a barcode on the 

labels for a quick and safe recognition. 

Quality makes the difference 

in critical moments 

To select a manufacturer as a 

supplier, with a high technical 

skill and a structured organization 

makes the difference in 

critical moments. It means to 

have certified pharma products, 

checked and in compliance with 

the regulations, but also being 

able to count on the advice of 

an expert partner. Essential elements 

for companies accustomed 

to face future scenarios 

with a “focus” to “risk base 

thinking” that really want to be 

prepared for the challenges of 

the future markets. 

A fast intervention makes the 

difference when it comes to assistance. 

That’s why BEA Technologies offers 

a team of qualified experts, 

able to support companies both 

in the selection phase and in 

the after-sales. 

Services available to the customer: 

filtration tests in the internal 

Lab an field tests at the 

customer’s site to size the system 

and optimize the filtration 

process; support in the validation 

of processes, with customizable 

specific validation protocols; 

international technical 

assistance; fast and reliable 

delivery times, confirmed at 

time of order; customer service 

available for all commercial requirements. 

Dedicated filtration solutions 

for specific applications 

Legislative constraints, typical 

problems, process complexity: 

each application has its own 

characteristics, which must be 

carefully considered in the selection 

phase of the most suitable 

filtration system. 

For each industry and application 

of the life science sector, 

BEA Technologies suggests one 

or more dedicated products. 


54_57_news componenti.indd 54 25/07/22 12:07


Components 

Sealing solution for flanged couplings that require electric conductivity 

GUAFLON ULTRA is ultimate certified 

sealing solution from Fluortecno 

for flanged couplings that require 

electric conductivity. 

This unique PTFE (poly-tetra-fluoro-ethylene) 

matrix allows 

electrostatic charges to freely move 

from the inner white layer in Guaflon 

SB TM to the outer layer in Guaflon 

EXD TM thus avoiding the creation 

of sparks. Guaflon ULTRA TM avoids 

the need of expensive and hassling 

earthings for piping and equipment; 

still, this special seal segregates the 

process fluid from any contamination 

of black particles. 

Characteristics: inner white core in 

Guaflon SB TM (PTFE charged with 

Barium Sulphate - modified and stabilized 

formula); approvals and certifications 

FDA 177.15.1550 and UE 

10/2011. 

Outstanding chemical resistance: 

suitable for all chemicals within the 

range PH 0 – 14; suitable for use in 

Food&Pharma environments outer reinforcement 

in black, conductive and 

antistatic. 

Mechanical properties: The exclusive 

isostatic and simultaneous moulding 

of the two materials provides the 

seal with a natural, multidirectional 

stability thus granting an excellent 

sustainability of thermal cycles and 

a superior resistance to permeation 

due to the barrier effect of the double 

sinterization. 

Electrical Properties: all laboratory 

trials have shown that GUAFLON UL- 

TRA gaskets, when compressed with 

variable clamping, possess a superficial 

resistivity of 30 - 130 Ohms thus 

granting the equipotentiality of the 

two ends. 

The pump at the heart of production 

Within the production process, the 

electric pump is the less complex and 

flashy element, but it actually represents 

its heart, as it pumps into the 

plant the product to be processed or 

as it collects the finished product to be 

sent to packaging machinery. For over 

50 years, Bruno Wolhfarth has been 

meeting the needs of its customers 

operating in the food, pharmaceutical, 

and chemical industries, offering user-friendly, 

easy to maintain and clean 

solutions, that at the same time are 

reliable and long lasting. Plant manufacturers 

and end users know the importance 

of the pump within the process, 

waiting either for a spare part or a 

maintainer for repair. Wolhfarth’s pump 

strong point is the simple disassembling 

and maintenance. The pump can 

be easily disassembled and reassembled 

even when installed by unskilled 

personnel. Either stainless-steel 316L 

or titanium for pumps working with 

corrosive acids are used. Machining 

from the solid bar, without casting or 

welding, guarantees the durability and 

the surface finish, also complying with 

the strictest standards in the food and 

pharmaceutical sectors. Flexible elastomer 

impeller enables a strong suction 

and the most powerful models can 

treat gently both creamy products such 

as yoghurt and the thickest ones, such 

as honey and jams. The ATEX-compliant 

version is available for use in areas 

at risk of explosion. The impeller and 

gasket materials are suitable for use in 

contact with food in compliance with 

current regulations. For detailed information 

and offers, please write to: info@wolhfarth.it. 



Components 

Monoblock single-stage centrifugal pumps 

The series TCHM of Pompetravaini 

consists of monoblock 

single-stage centrifugal 

pumps with closed 

impeller. Built according 

to ISO standard 2858 and 

5199 these sturdy and reliable 

pumps are available at 

low price coupled with the 

easy operation of monobloc 

units. The series TCHM is of 

the highest quality, with attractive 

prices to the chemical 

and industry in general. 

Technical Details: 

• The connections are 

flanged to UNI2223-2229 

NP16 standard. Liquids 

up to 140 °C can be handled. 

These pumps can cover 

a wider range of duties 

and applications than ordinary 

monoblock pumps 

and those pumps which are 

stamped out of sheet metal. 

• Shrouded type impellers 

are suitable for handling 

either clean or contaminated 

liquid. 

• The pump casings, impellers 

and casing covers are 

the same as for TCH series. 

This reduces inventory costs 

and the provision of spare 

parts at reduced prices. 

• Capacity up to 500 m3/h 

and head up to 10 bar. 

Thanks to new acquisitions, 

international sales offices, 

and a broad network 

of agents and distributors, 

Pompetravaini has become 

a global authority in the 

pump industry that exports 

its products worldwide to 

over 80 countries with the 

guarantee of a solid experience 

of more than 90 years 

of history. 

OUR STANDARD: 

INNOVATIVE SOLUTIONS 

FOR YOUR ASEPTIC 

PROCESS. 

STERILINE Srl 

Via Steriline Tentorio S.r.l. 30 - 22100 Como - 

Italy - www.steriline.it 

Via Tentorio 30 - 22100 Como - Italy 

www.steriline.it | 



Engagement as key 

for Digital Transformation 

Sintetica is one of the most advanced medium-sized pharmaceutical 

companies in digital transformation. The IT Corporate Executive Director 

of the Swiss Company took part to SPS Italia and ISPE Italia round table 

about “Digitalization and Pharma 4.0” and said: 

“Active involvement of People is important 

as much as technology”. 

by Alessandro Bignami 

“A 

real digital transformation 

is possible 

only with every 

stakeholder’s par- 

Davide Ferrara, 

Sintetica 

Digital Affairs 

Corporate 

Executive 

Director 

lia on April in Milan. He gave his take 

to the discussion by communicating 

to the audience his direct experience 

for the creation of a 4.0 roadmap in a 

medium-sized company. To do that, 

Ferrara did not just talk about technologies 

and systems, but above all 

about digital awareness and focus on 

ticipation”. Davide 

Ferrara, Sintetica Digital Affairs Corporate 

Executive Director, was invited 

as speaker to “Digitalization and 

Pharma 4.0 in Life Science” event, 

organized by SPS Italia and ISPE Itapeople. 

“Digital is the 

enabling technology, but what matters 

is to transform the way of doing 

business, the organization, the 

processes. And this can be done only 

by involving all departments”. During 

the event, that took place in the 

wide spaces of Bovisa’s MADE Com- 


58_60_articolo sintetica.indd 58 25/07/22 12:11


petence 4.0, we had the opportunity 

to discuss some of the topics 

touched upon in the presentation 

with the manager. 

Davide Ferrara, can you briefly introduce 

Sintetica? 

Sintetica is a medium-sized company 

based in Canton Ticino, that celebrated 

100 years in 2021. It has a 

long and successful history in the 

field of pharmaceutical research. We 

produce aseptic drugs and are leaders 

in the production of injectable 

solutions such as local anesthetics 

and analgesics, products therefore 

intended primarily for intensive care 

and for the operating room. These 

drugs are mainly used by anesthetists 

and health workers in hospitals. 

Three years ago the company was acquired 

by a fund that further broadened 

the growth outlook and laid the 

foundations for a new phase of acceleration 

leveraging digitalization and 

innovation. 

What’s your size today? 

We’re more than 300 people overall, 

spread in four main legal entities: 

two in Switzerland, one in Germany 

and one in UK. Our products are 

distributed worldwide with a model 

that provides both a “Business to 

Consumer” channel with direct sales 

to hospitals and pharmacies and a 

“Business to Business” channel, 

where we operate thanks to multiple 

strategic distribution partnerships. 

When did you join the company 

and what skills did you bring? 

I joined Sintetica about three years 

ago, after twenty years of experience 

in the pharma industry with one of 

the top management and strategic 

consulting firm. I spent majority 

of my career supporting or leading 

transformation programs worldwide 

with many pharma multination- 

al companies. In Sintetica, I was given 

the task to coordinate the whole 

digital transition program as Corporate 

IT Director. I found a company 

strongly focused on people’s value 

and innovation, two elements in 

tune with my approach to digitalization. 

Technology plays a key role in 

terms of digital transformation programs 

since it can enable change and 

accelerate growth, but the emphasis 

must be placed on transformation. 

Previous experiences taught me 

that when people are not really involved 

and fully engaged in this kind 

of large transformation program, it 

is difficult to be really successful. 

The ability to overcome change resistance 

and the experience in dealing 

with natural defensive attitude 

towards new technologies and innovation 

becomes fundamental. 

From this perspective, it is crucial 

to support the program with concrete 

initiatives aimed to facilitate 

the change not limiting them just 

to communication or training activities. 

It is necessary to intervene 

deeply on the way of working, to 

facilitate continuous alignment towards 

company objectives, stimulate 

a more and more rooted digital 

awareness. These aspects aren’t 

less important than technologies 

and are even more complex than 

technologies, for which we can at 

least rely upon system integrators. 

In the end, what counts are a clear 

vision and the capability of integrating 

technical and business skills 

“We have set an extremely ambitious program considering 

the systems and technologies we are implementing 

and the timescales we have set to achieve the individual 

objectives. 2022 will be a turning point” 





throughout all the digital transition 

program steps. 

How far did you arrive with your 

digital transformation journey? 

We are just over halfway. We have 

set an extremely ambitious program 

considering the systems and 

technologies we are implementing 

and the timescales we have set to 

achieve the individual objectives. 

2022 will be a turning point, as 

four of the five initiatives we have 

launched in this transition phase 

will be fully operational. It is a first 

and important program checkpoint, 

which can already generate an important 

breakthrough. We expect to 

integrate all the company processes 

on a single integrated platform. 

It is an evolution that I consider 

even more significant after listening 

to ISPE Italia’s survey, according 

to which many companies, similar 

to ours in size, are still wondering 

how it is best to move on the 

digital issue. 

How did the pandemic influence 

your path? 

It was not an easy challenge. In 

some ways, it accelerated the 

change that we had already started. 

For everybody, it was a dramatic 

period, but I also like to look at 

the positive effects for the company’s 

evolution. I think for instance 

about the lesson we learned about 

smart working. Today companies 

are realizing that home work is not 

incompatible with business objectives 

and it can even promote an 

increased productivity. 

Of course, it cannot involve any 

business task and must be analyzed 

also according to local regulations, 

but it proved to be a virtuous 

tool. Another inheritance of this 

terrible emergency features a more 

commercial nature and regards new 

ways to do business and the possibility 

to involve customers through 

digital channels. These experiences 

will bear fruit even when the 

pandemic will be completely behind 

us. Companies that, in front of 

these changes, proved to be more 

reactive over the next years will be 

seeing an increase in their competitive 

advantage. 

Does the digital offer peculiar 

opportunities for the pharma industry? 

Yes it does, since the pharma industry 

is subject to regulations that cannot 

be compared to the ones of other 

“In Sintetica, all are 

an integral part 

of digital evolution 

and are invited to feel 

it their own and to 

appreciate its benefits, 

so that to give an active 

contribution 

and feeling like actors 

of change” 

industries and that unavoidably involve 

a specific approach to digital 

transformation, that must take into 

account of validation procedures 

and test protocols Industry specific. 

I think for example about the need 

of transparency, data integrity and 

compliance in general. With this in 

mind, technology is also a valid ally 

to respond to the requirements 

of the complex regulatory apparatus 

that regulates the industry and 

is constantly evolving. 

There’s the need of complying with 

regulations and validating every 

innovation: doesn’t it curb change 

towards new technological and IT 

systems? 

No, it doesn’t, if this system of rules 

offers a real improvement towards 

product quality, process transparency 

and integration. On the contrary, 

regulation is appreciated by 

the most virtuous companies and, 

thanks to the fat it so strict, it protects 

the patient and subsequently 

the pharma manufacturer. Look at 

counterfeiting. The ISPE survey itself 

reveals that about one out of 

five drugs purchased on the internet 

is counterfeit. This jeopardizes 

the patient’s health and the credibility 

of the industry. And it explains 

well why every step towards 

more controlled and traceable processes 

can only be viewed favorably 

by both industry and clinicians 

community. 

What do you expect over the next 

few months? 

We are living a very dynamic phase 

of our company history and in this 

year, several initiatives will bring 

some initial results. We aim at being 

pioneers in digital transformation, 

at least among the pharmaceutical 

companies of our size. The 

whole company management team 

is involved in this transition and in 

the coming months, with completion 

of the various initiatives, majority 

of company’s employees will 

be involved as well. We tried to 

overcome the usual way of working 

according to which departments 

express business requirements and 

the IT area selects and develops 

appropriate solutions. 

All of them are an integral part of 

digital evolution and are invited to 

feel it their own and to appreciate 

its benefits, so that to give an active 

contribution and feeling like actors 

of change. I’m convinced that only a 

wide participation and engagement 

allow to realize the potential of digital 

transformation. 

 



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Less is More 

An innovative rotating cleaning nozzle with 

a special flat fan design developed by Lechler, 

saves time and money through uniform coverage 

when cleaning tanks. In a series of 

tests, it was capable of reducing the cleaning 

time by 40% and fresh water consumption 

by 30% in comparison to conventional 

spray balls. 

Reliable cleaning processes 

reduce the risk of claims 

Hygiene is absolutely essential to ensure 

the quality and uniformity of goods that 

are manufactured, filled and packaged. Industrial 

cleaning processes such as Cleaning 

in Place (CIP) provide a long-term contribution 

in maintaining the required hygiene 

levels and protecting manufacturers 

against expensive claims which can damage 

their reputation. The required cleaning 

jobs must be performed quickly and more or 

less in between production. Longer downtimes 

result in higher costs. 

With modern cleaning processes, the focus 

is no longer on effectiveness but efficiency. 

Optimally matched factors achieve the 

desired cleaning result with the economical 

use of resources. The main four factors here 

are mechanics, chemistry, time and temperature 

(Sinner Circle). 

Predictable return on investment 

The cost associated with this nozzle is paid 

off quickly, especially when you compare the 

significant reduction in lower operating costs. 

More efficient cleaning systems will also 

become increasing important in production 

plant as well in the future. The goal is to 

show how the cleaning result is affected by 

gradually increasing the operating pressure 

and the size of the tank. The results will be 

used by Lechler for further optimization of 

the rotating cleaning nozzle. 

In order to increase process reliability even 

further, the rotating cleaning nozzle can also 

be optionally combined with a rotation 

monitoring sensor. 

Renowned plant manufacturers have placed 

their trust in the nozzle technology and 

know-how of Lechler company for many years 

now. Reduction in the costs for energy, 

natural resources and additives is an important 

argument in the industry. 

Lechler never focuses on just the individual 

nozzles but always on the overall process. 

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62_63_news lechler con adv.indd 60 25/07/22 12:12

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62_63_news lechler con adv.indd 61 25/07/22 12:12


Endress+Hauser lays the 

groundwork for the future 

For Endress+Hauser, the expansion of the campus in 

Reinach is a commitment to Switzerland as a business 

location. The company is creating more space for the 

production of flow measurement technology and the 

development of IIoT solutions. 

Endress+Hauser continues on 

the path to growth. Over the 

past five years the number of 

employees at the Reinach location 

in the Swiss canton of 

Basel-Landschaft has grown by 20 

percent to more than 2,000. At the 

same time, the number of units produced 

has significantly increased and 

the digital solutions portfolio has expanded. 

In order to simultaneously 

meet the new demands of the work 

environment, vocational training positions 

and digitalization, the measurement 

and automation technology specialist 

invested 60 million Swiss francs 

in the Reinach campus. 

After beginning work on the foun- 

dations in 2019, Endress+Hauser will 

celebrate the opening of the nearly 

150-meter-long building in Reinach 

on 1 July 2022. The construction plan 

included the use of available property 

and an existing building located 

on Kägenstrasse. The new facility, 

which boasts more than 25,000 

square meters of space, equivalent to 

around four soccer fields, was built 

with roughly 19,000 cubic meters 

of concrete and 2,200 tons of reinforced 

steel and other materials. 

The new building is home to Endress+Hauser 

Flow, the product 

center for flow measuring technology, 

as well as Endress+Hauser Digital 

Solutions, which is responsible 

within the Group for all issues re- 


64_66_ART_endress.indd 64 25/07/22 12:10


lated to digital communication and 

automation solutions. The first wave 

of employees has already moved into 

the facility. 

Production expansion 

and additional jobs 

With the new building, Endress+Hauser 

is responding to the ongoing demand 

for high-quality instrumentation 

and solutions for Industrial 

Internet of Things (IIoT) environments 

in the process industry. Liquids 

and gases must always be monitored, 

measured and settled with a 

high degree of accuracy. This is being 

driven, among other things, by 

increasingly strict government regulations 

and growing requirements 

on quality and environmental protection 

around the world. 

Endress+Hauser Flow has reacted 

to this development, expanded its 

portfolio and doubled the number of 

units produced over the past decade. 

The consequence is continuous expansion 

of the production capacity 

and the creation of additional jobs. 

With the most recent developments, 

the family company is making a clear 

commitment to Reinach and the Basel 

region where the Group is firmly 

rooted. 

Focus on collaboration 

As a result of the expansion, around 

1,050 employees will move across 

all buildings. The additional space 

will create more collectively used 

workspace. “In the spirit of ‘New 

Work’, we are implementing activity-based 

working. Different work areas 

will be available for different activities, 

meaning that our employees 

can choose the space best suited 

to their individual tasks,” says Mirko 

Lehmann, Managing Director of Endress+Hauser 

Flow. 

Special coworking zones such as Innovation 

Labs or project zones furthermore 

offer different departments 

Endress+Hauser 

has invested 

60 million 

Swiss francs 

in the Reinach 

campus 

Among other 

products, 

Endress+Hauser 

manufactures 

high-quality 

flowmeters in 

Reinach for 

monitoring 

and measuring 

liquids and gases 



64_66_ART_endress.indd 65 25/07/22 12:10


The heart of the 

heating system 

is a stratified 

tank that stores 

waste heat 

the opportunity to collaborate on 

longer-term projects. Employees 

can choose between a permanent or 

shared desks. Bright, friendly spaces 

and a modern infrastructure have 

a positive impact on the work environment 

as well. 

Learning-conducive 

training environment 

For Endress+Hauser, laying the groundwork 

for the future also means investing 

in the employees of tomorrow. The 

new building brings training and education 

into the heart of operation and 

offers sufficient space for areas conducive 

to learning with workshops, 

labs and training rooms, thus allowing 

an increase in the number of apprenticeship 

positions and vocational 

careers. To date, 43 apprentices have 

been trained in eight areas. Beginning 

in August, nearly 50 apprentices will 

be trained in 11 vocations. This number 

is expected to grow over the next 

five years. 

Around 4,000 annual visitors can look 

forward to the new plant tour and hospitality 

concept. This concept consists 

of a redesigned reception area 

and a new visitor center including 

“Flow Experience”, an integrated 

2,000-square-meter area where the 

Endress+Hauser brand and flow instrument 

portfolio can be experienced before 

taking a tour of the plant. 

Sustainable energy concept 

Endress+Hauser is furthermore using 

the new building to align its ongoing 

business growth even more closely 

with its ecological and social responsibilities. 

In light of the goal 

of the Endress+Hauser Flow sustainability 

strategy to operate its buildings 

in Reinach in a CO 2 

-neutral manner 

by the year 2030, high value is 

being placed on climate-friendly facilities 

management. As part of the 

energy concept, for example, waste 

heat is stored in a stratified storage 

tank for warm water and then used 

for heating. A comprehensive energy 

monitoring system using instru- 

ments from the company’s 

own portfolio also helps to 

continuously optimize operation 

of the buildings. 

Large photovoltaic systems 

were installed on the roof 

of the new building, which 

boast a peak capacity of 

365 kilowatts, enough to 

cover the annual electricity 

needs of around 75 single-family 

homes. In Reinach, 

Endress+Hauser now 

has photovoltaic systems 

covering more than 3,700 

square meters with a total 

peak capacity of roughly 

1 megawatt, making the 

company one of the largest 

solar power producers 

in the Basel region. The 

roof is also home to two 

bee colonies and various 

bee-friendly flowers, a project that 

contributes to the preservation of biodiversity 

as these small insects are 

considered central Europe’s most important 

plant pollinators. 

Measurement and automation 

technology for process 

and laboratory applications 

Endress+Hauser is a global leader in 

measurement and automation technology 

for process and laboratory 

applications. The family company, 

headquartered in Reinach, Switzerland, 

achieved net sales of approximately 

2.9 billion euros in 2021 

with a total workforce of more than 

15,000. 

Endress+Hauser was founded in 1953 

by Georg H Endress and Ludwig Hauser. 

Ever since, the company has been 

pushing ahead with the development 

and use of innovative technologies, 

now helping to shape the industry’s 

digital transformation. 8,600 patents 

and applications protect the 

Group’s intellectual property. 


64_66_ART_endress.indd 66 25/07/22 12:10


A pioneer brand in industrial 

instrumentation 

Terranova pneumatic and electronic instruments 

for automation and control can be system integrated into 

turn-key systems for various industrial sectors. 

TERRANOVA® engineers and manufactures 

pneumatic and electronic 

instruments for Automation and 

Control, which can be system integrated 

into turn-key systems for 

various industrial sectors: Chemical, 

Oil & Gas, Pharmaceutical, Food, 

Power and Naval. ISO9001, 

ATEX, IEC-Ex, PED and SIL certifications 

guarantee the products to 

be compliant with the up-to-date 

technical standards. The consolidated 

activity of Terranova in Italy 

is integrated by a growing export 

activity in many foreign countries, 

managed by an internationally 

selected and well-trained Sales 

Network. Terranova products are 

available in standard (Carbon Steel, 

Low temperature Carbon Steel, 

316 & 321 Stainless Steel,) and 

special alloys (Hastelloy C, Duplex, 

Monel, Titanium, Inconel, etc.) all 

compliant to NACE latest requirements. 

The product range is including 

pressure, differential pressure, 

level and temperature electronic 

transmitters. The working principles 

of transmitters are also quite 

wide to better fit the application: 

Differential pressure 

transmitters 

torque tube, buoyancy, hydrostatic 

pressure (piezoelectric, ceramic 

and capacitive) & resistive for the 

measure of level or interface level; 

piezoelectric, ceramic and capacitive 

for the measure of pressure 

and differential pressure, thermo 

resistance or thermocouple for 

the measure of temperature. 

Torque tube level transmitter 

SST50 and SST70 series SMART level 

transmitters are microprocessor 

based instruments that combine 

the analog signal advantages 

(4-20mA) together with the 

flexibility of digital communication 

(HART®, FF, PA) protocol. The 

transmitter series SST70 measures 

liquid levels, density and interface 

levels in closed or open vessels. 

It converts buoyant force exerted 

by a displacer immersed in a liquid 

to a proportional current signal 

thanks to a mechanical forces 

transmission device based on 

a torque tube and a piezoresistive 

sensor. 

Temperature 

transmitter 

SST52 and SST72 series 

SMART temperature transmitters 

are able to accept 

3 wires Pt 100 ohm 

resistance thermometers 

and total accuracy is depending 

on class of the 

sensors utilized such as 

DIN A, DIN B, 1/4 DIN, 

1/10 DIN, etc. Based on 

these readings the microprocessor 

generates 

the 4-20 mA analog output 

“two wires system” and displays 

the pressure measurement on the 

LCD. Some of the main characteristics 

of this microprocessor-based 

transmitter, are: wide rangeability; 

automatic temperature compensation; 

digital communication 

using HART, PA or FF protocol. 

Differential pressure 

transmitter 

SST57B and SST7TB series SMART 

differential pressure transmitters 

can be remotely configured 

by a universal hand-held terminal 

(HHT) or by a PC with a dedicated 

interface and Terranova 

software. Moreover, it is possible 

to locally configure the instruments 

(zero and span) by means 

of 2 push buttons and to display 

the data on the wide LCD 

display. The SST57B transmitters 

measure differential pressure 

with spans from 1,125 to 

20000 mbar with a static pressure 

up to 100 bar. Thermal drift 

is compensated using the temperature 

signal generated by a 

PTC thermistor integrated in the 

sensor itself. 

Torque tube level 

transmitters 

Current to pressure 

converter 

SEX71A current to pressure 

converters are based 

on a force balanced 

system with electronic feedback: 

measuring the output signal, 

by means of a piezoelectric sensor, 

and computing it with dedicated 

SMT electronics, a 

reliable and high performing 

instrument is obtained. 

An extraordinary accuracy 

less than 0,25% 

(comprehensive of non linearity, 

hysteresis and repeatability errors) 

is reached by this converter, 

4 times better than what typically 

found on the market. The converter 

is provided with intrinsic safety 

approval. 

Pneumatic indicating controllers, 

regulators, recorders 

Ideal for the control of temperature, 

pressure and level, in industrial 

or process plants as the indicating 

controller is used for control of liquid, 

gaseous or vaporous media. 

The instrument senses the temperature, 

pressure or level of the measured 

medium directly, displays the 

operating value, compares the measured 

variable with the set point 

and puts out a pneumatic standard 

signal of 0,2 to 1bar or 3 to 15psi. 

This output pressure actuates final 

control element, the pneumatic 

valve. Four control forms are available: 

ON-OFF, Proportional + Integral 

+ Derivative. The units could 

be also used for remote control 

of process operations as pneumatic 

transmitter (output 0,2÷1bar or 

3÷15psi) or receiver controller (input 

0,2÷1bar, 3÷15psi). 



67_67_NEWS_terranova.indd 67 25/07/22 11:55

Tribology 

Take back control 

Losing heat? Can’t cool it down? Seems like the heat transfer 

system needs a tune-up. Time has come to take back control 

of the heat exchangers and cooling towers. 

by Jonathan 

Venditti* 

Photo 

©shutterstock / 

Red_Shadow 

by Jonathan Venditti* 

*Global Market 

Manager 

Chemical Industry, 

Klüber Lubrication 

es require thermal flexibility and stability, 

heat exchangers are essential 

for chemical and petrochemical companies. 

Heat transfer systems used in 

the chemical industry can be based on 

different concepts and technologies 

and use a wide range of heat transfer 

fluids. The majority of chemical companies 

will use mineral oils or water 

to carry, dissipate or exchange heat in 

their processes. However, regardless 

of the thermal fluid in use, heat trans- 

The chemical industry is producing 

a huge variety of 

chemicals by using various 

processes. Most of the time, 

however, basic chemicals are 

reacting with each other to obtain 

the desired finished chemical. While 

some chemical reactions require heat 

in order to take place (endothermic), 

some others, on the contrary, release 

a fair amount of heat once initiated 

(exothermic). Because their processfer 

systems will lose efficiency over 

the years because of fouling. Fouling 

is the accumulation of undesirable 

material such as varnish, sludge, 

algae, scale, insoluble salts and minerals 

on the internal surface of heat 

transfer systems. The following article 

provides more information on fouling 

and suggests how to prevent this phenomenon 

from causing efficiency loss 

in heat transfer systems. 

For all of the challenges heat transfer 


68_71_articolo kluber.indd 68 25/07/22 11:48

Tribology 

systems can pose, the tribology specialist 

Klüber Lubrication has developed 

highly efficient solutions which 

can help to restore the full efficiency 

of water circulation and cooling 

systems. 

Get more out of oil circulation 

systems 

Regardless of whether they are designed 

to heat or cool down processes, 

most oil-circulating heat transfer 

systems in chemical and petrochemical 

facilities still use group I mineral 

oils in this heavy-duty application. 

Group I mineral oils are derived from 

crude oil. The refining process uses a 

solvent which leaves impurities and 

hydrocarbon molecules of different 

sizes in the mixture. Some heat transfer 

systems can use up to a hundred 

thousand liters of oil as a transfer medium, 

which makes group I mineral 

oils with their affordable price attractive 

for chemical companies. 

In most cases, heat transfer systems 

are far from being perfectly designed. 

In the majority of the systems, the 

oil is subject to considerable stress, 

due to an intense localised heating 

source in combination with low flow 

velocity. The oil can also come into 

contact with the air in the expansion 

tank, causing it to oxidize and degrade 

faster. Group I oils contain unsaturated 

hydrocarbons and asphaltene 

components that react with ox- 

ygen, provoking degradation at high 

temperature. 

Pushing group I mineral oils to their 

performance and service life limits in 

heat transfer systems will most likely 

lead to varnish or carbon buildup 

throughout the circulation system, 

which will definitely cause fouling 

and over time affect system efficiency. 

The tribology specialist Klüber 

Lubrication is well aware of the challenges 

heat transfer systems can represent 

for chemical companies, and 

has developed a comprehensive range 

of products and solutions for this application. 

The highly refined and hydrotreated 

base oils used in these 

products offer much better stability 

at high temperature and make extended 

service life possible. 

Meeting the requirements perfectly 

Modern heat transfer systems are operating 

in harsh conditions and may 

require a special thermal fluid or special 

compliance features such as NSF 

H1 registration for incidental contact 

with food. Technology advancement 

in heat transfer fluids has resulted 

in consumers today having 

a wide range of options to choose 

from according to their needs. Thermal 

fluids based on different chemistries 

like polyalphaolefin, polyalkylene 

glycol or silicone can show numerous 

advantages in certain applications 

and could be the right alternative 

where conventional mineral 

oils are not suitable. 

Detailed analysis, monitoring and 

maintenance 

If you have recently noticed damage 

caused by a group I mineral oil to your 

system, and realized how poor the efficiency 

of your heat exchange system 

has become over the years, you 

should know that a suitable cleaner/ 

conditioner for example from Klüber 

Lubrication can restore the system’s 

efficiency without the need for dismantling 

or prolonged shutdown. Efficient, 

headache-free operation of 

heat transfer systems begins with a 

Limestone 

deposits, 

usually 

composed of 

calcium and 

magnesium, 

are a plague on 

the operational 

efficiency of air 

compressors, 

heat 

exchangers, 

vacuum pumps, 

boilers, cooling 

towers and 

other equipment 

in touch with 

water 

(Photo 


High Simple) 

If not properly 

treated, 

sediments, 

sludge and 

deposits that 

accumulate 

cause a loss of 

efficiency and 

increase energy 

consumption. 

In the photo 

beside washing 

and after 

cleaning the 

encrustations 

and rust with 

chemicals 

(Photo 


Paradorn Kotan) 




Tribology 

good oil monitoring program. Just like 

blood testing can be useful to analyse 

health issues, an oil sample from the 

heat transfer system can reveal crucial 

information to help prevent eventual 

failures, safety issues, and even fires. 

No tolerance for intruders 

in water circulation systems 

For processes where the heat is not 

that critical, or where cooling is needed, 

most chemical companies will rely 

on water circulation systems. Fouling 

also occurs in water circulation systems, 

as non-distilled industrial water 

contains mineral salts that can 

Scale deposits, usually calcium and 

magnesium compounds, affect the 

operating efficiency of air compressors, 

chillers, exchangers, vacuum 

pumps, boilers, cooling towers 

and other water-wetted equipment. 

If not properly treated, sediment, 

sludge, and scale building 

up in the recycled water leads to a 

loss of efficiency and increases energy 

consumption. Poorly maintained 

systems can also harbor legionella 

bacteria, which pose a health risk to 

those working near such equipment. 

Every year, the chemical industry 

loses billions of dollars in revenue 

bring it back to top operating efficiency. 

Klüber Lubrications offers a 

complete range of high-performance 

descalers, which are enhanced with 

wetting agents, corrosion inhibitors 

and degreasing compounds. These 

are designed to penetrate and remove 

encrusted limescale, rust, dirt 

and corrosion byproducts from water-wetted 

inner surfaces of commercial 

and industrial processing equipment. 

Some high-technology descalers 

also contain active dyes that 

changes color in order to let the operator 

know when action is required. 

However, not all descaler chemistries 

are suitable for all kinds of metal surfaces. 

For example, special attention 

has to be paid to electroplated and 

aluminium surfaces, as traditional 

descalers based on mineral or organic 

acids could attack and damage 

these surfaces and components. It is 

therefore advisable to contact a specialist 

like Klüber Lubrication before 

cleaning a water circulation system. 

The tribology expert provides technical 

service, develops efficient cleaning 

procedures and can even assist 

maintenance teams on-site in cleaning 

operations. 

©TurboSquid / 

Max3dModel 

bond to metal surfaces. The difference 

between water and oil circulating 

systems is the fouling factor, a 

mathematical value (usually referred 

to as Rf or Rd) that quantifies the theoretical 

resistance to heat flow due to 

the build-up of a layer on the internal 

surfaces of heat exchangers. It is a ratio 

between the transfer coefficient of 

a clean heat exchanger and the same 

unit after a fouling problem has set 

in. The standard fouling factors for 

common liquids and gases are specified 

in a formal list, which is easily 

accessible on the internet. 

due to equipment downtime and increased 

power consumption, caused 

by limescale build-up clogging the 

pipes of the production equipment. 

Back to top operating efficiency 

in a quick, safe and easy way 

Considering that equipment like cooling 

towers only offers an efficiency 

of 70 to 75 %* from the outset, it is 

easy to imagine how poor the efficiency 

becomes once a 3-6 mm layer 

of scale has built up. Water-based 

descalers provide a quick, safe and 

easy way to clean the equipment and 

Conclusion 

As a long-standing partner of the 

chemical industry, Klüber Lubrication 

has developed a variety of highly 

efficient products for all applications 

in heat transfer systems. These 

highly efficient heat transfer fluids, 

cleaners/conditioners and descalers 

can help to get back the efficiency 

of water circulation and cooling 

systems. Taking into account the individual 

requirements and specific 

conditions of the application, Klüber 

Lubriation will provide not only the 

right products, but the company also 

offers all kinds of services required 

in order to optimise the efficiency of 

the process. 

 



THINKING 

Process Service srl è una società di ingegneria, che dal 1986, opera nell’erogazione 

di servizi di consulenza e progettazione, con una elevata specializzazione negli 

impianti chimici e farmaceutici. Process Service è in grado di accompagnare il cliente 

lungo tutto il corso di un progetto sia nuovo che di revamping. 

Sviluppo del processo e dell’ingegneria di base-Ingegneria di dettaglio-Supporto al 

procurement-Gestione cantiere-Precommissioning-Commissioning e avviamento. 

Via Alcide De Gasperi 111 20017 Rho (MI) Tel: 02 939 09 272 Fax: +39 02 939 06 328 

info@process-service.it 

www.process-service.it 


In this issue, 

we spoke about... 

ACHEMA .......................................................................11 

ANTARES VISION GROUP .....................................14, 25, 26 

ASCO FILTRI ............................................................ 13, 30 

BEA TECHNOLOGIES ....................................... 54, 3 rd COVER 

BRUNO WOLHFARTH ..........................56, BACK COVER FLAP 

CEFIC ............................................................................ 16 

CHIESI FARMACEUTICI ..................................................... 14 

CO.RA. ...................................................... 30, BACK COVER 

COESIA GROUP ............................................................... 36 

CSV LIFE SCIENCE ...............................................COVER, 10 

DOMPÈ FARMACEUTICI ..................................................... 12 

EATON ........................................................................... 31 

EFFEBI ..........................................................................55 

EFPIA..............................................................................6 

ELLAB .......................................................... 2 nd COVER, 44 

ENDRESS+HAUSER ........................................................... 64 

FACHPACH ..................................................................... 18 

FARAVELLI ....................................................................49 

FF.GI. ...........................................................................23 

FLUORTECNO ...................................................56, INSERTO 

GSK .............................................................................. 11 

IMA .............................................................................. 32 

ISPE ............................................................................. 14 

ITALVACUUM .................................................................. 26 

ITELYUM .......................................................................61 

KLÜBER LUBRICATION ..................................................... 68 

LECHLER .................................................................62, 63 

LIFEBEE ........................................................................27 

MARCHESINI GROUP........................................................ 34 

MG2 .............................................................................. 33 

MONTENEGRO ................................................................19 

MOTT & ASCO ................................................................. 30 

NUOVA GUSEO ................................................................ 50 

OQEMA ..................................................................... 9, 38 

POMPETRAVAINI ........................................................ 1, 57 

POWTECH ................................................................ 15, 18 

PROCESS SERVICE ..........................................................71 

PVS GROUP ...................................................................37 

RADICIGROUP ................................................................ 42 

S4S ........................................................................ 41, 46 

SALVATORE ROBUSCHI ............................................. 30, 45 

SINTETICA ..................................................................... 58 

STERILINE ............................................................... 24, 57 

STEVANATO GROUP .......................................................... 15 

SWAN ANALITICA ..........................................................35 

TERRANOVA INSTRUMENTS ....................................... 31, 67 

TEXPACK ................................................................... 5, 28 

TM.I.P. ..................................................FRONT COVER FLAP 

UNIVERSITY OF BRESCIA .................................................. 12 

VTU ..............................................................................53 

WORLD BIOECONOMY FORUM ............................................ 16 

YSTRAL ......................................................................... 34 

icf 

YEARXIII 

SUPPLEMENT ISSUE 

NO.3 2022 

MANAGING DIRECTOR: Simone Ghioldi 

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Eva De Vecchis (e.devecchis@interprogettied.com) 

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72_72_COLOPHON.indd 72 25/07/22 14:07


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

A reliable company for non-conventional processes and solutions… 

 

 

 

 

TM.I.P. S.r.l. – Termomeccanica Industrial Process 

Tel. +39 0187 513.410 • Fax. +39 0187 515.352 

Visita il nostro sito www.tmip.termomeccanica.com

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