5 years ago

MyCells® - Platelet Rich Plasma harvesting kit : from ... -

MyCells® - Platelet Rich Plasma harvesting kit : from ... -

Introduction Activated

Introduction Activated platelets release: � adhesive glycoproteins � growth factors Following subcutaneous injection, these proteins and GF interact with cells residing in the subcutaneous tissues. eg: � skin fibroblasts � endothelial cells, � osteoblasts. Upon binding to their cellular receptors, glycoproteins and growth factors activate intracellular signaling events, mediating: � Angiogenesis � cell proliferation, � migration, � survival � production of extracellular matrix proteins. 61

Introduction (2) �In view of the crucial role of angiogenesis in wound healing and tissue regeneration, we examined the effect of activated platelets on the expression of 84 genes involved in positive and negative regulation of angiogenesis in endothelial cells, using a specialized real-time PCR array. �Platelet activation was performed by thrombinreceptor activating peptide (TRAP). 62

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