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Copyright by Eunyoung Park 2007
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Retinol Inhibits the Growth and Inv
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Retinol Inhibits the Growth and Inv
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Table of Contents LIST OF TABLES IX
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List of Tables TABLE 3.1. SEQUENCE
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FIGURE 6.1. RETINOL DECREASES PI3K
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Colorectal cancer caused by MSI inc
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(12). The protein levels of MMP-2 a
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deficiency reduced the size of colo
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ATRA induces the expression of the
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FIGURE 1.1. GENETIC ALTERATIONS ASS
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Chapter 2: Retinol Inhibits the Gro
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etinol and retinyl esters. Retinyl
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sensitivity at the time of harvest:
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plates before treatment with 0, 1,
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RESULTS Growth of ATRA-resistant co
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corrected for cell number, HCT-116
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Retinol is not acting through the R
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Figure 2.1. The percent of cells th
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4-Oxoretinol and AR are two natural
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activation (73). In contrast to our
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FIGURE 2.1. RETINOL INHIBITS THE GR
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FIGURE 2.2. RETINOL IS NOT METABOLI
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FIGURE 2.4. RETINOL DOES NOT ACT TH
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FIGURE 2.5. RETINOL DOES NOT INDUCE
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FIGURE 2.6. RETINOL ALTERS CELL CYC
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RAR-independent mechanism that may
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cleaved within the intestinal lumen
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through the membrane were fixed in
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calculated by the comparative CT me
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Statistical Analysis Values shown a
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increased gene transcription and tr
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conditioned media (Fig. 3.4B and D)
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is mediating the inhibitory effect
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shown to decrease MMP-1 mRNA levels
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- Page 73 and 74: FIGURE 3.1. EFFECT OF RETINOL ON AT
- Page 75 and 76: FIGURE 3.3. EFFECT OF RETINOL ON MM
- Page 77 and 78: FIGURE 3.4. EFFECT OF RETINOL ON MM
- Page 79 and 80: FIGURE 3.6. EFFECT OF RETINOL ON TI
- Page 81 and 82: Thus, a decrease in PI3K activity d
- Page 83 and 84: MATERIALS AND METHODS Tissue Cultur
- Page 85 and 86: Western Blot Analysis Cells were pl
- Page 87 and 88: Invasion Assays Cells were serum st
- Page 89 and 90: Statistical Analysis Quantitation w
- Page 91 and 92: Retinol decreases PI3K activity by
- Page 93 and 94: Retinol and wortmannin exhibit simi
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- Page 97 and 98: mouse fibroblast (151), cultured va
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- Page 101 and 102: FIGURE 4.1. RETINOL DECREASES PI3K
- Page 103 and 104: FIGURE 4.2. RETINOL DOES NOT CHANGE
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- Page 107 and 108: FIGURE 4.5. RETINOL AND WORTMANNIN
- Page 109 and 110: Chapter 5: Dietary Vitamin A Decrea
- Page 111 and 112: Recent studies in our laboratory sh
- Page 113 and 114: provided every other day and feed c
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- Page 117 and 118: The effect of retinol on tumor mult
- Page 119 and 120: - NRC rat vitamin A requirement) (4
- Page 121: cancer. Therefore, determination of
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- Page 127 and 128: FIGURE 5.4. IMMUNOHISTOCHEMICAL DAT
- Page 129 and 130: sensitive and ATRA-resistant colon
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- Page 133 and 134: References 1. American Cancer Socie
- Page 135 and 136: 31. Freemantle, S. J., Spinella, M.
- Page 137 and 138: 63. O' Connell, M. J., Chua, R., Ho
- Page 139 and 140: 93. Lee, M. O., Han, S. Y., Jiang,
- Page 141 and 142: 121. Fong, K. M., Kida, Y., Zimmerm
- Page 143 and 144: 151. Antonyak, M. A., McNeill, C. J
- Page 145 and 146: 182. Council, N. R. (1995) Nutrient