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Copyright by Eunyoung Park 2007 - The University of Texas at Austin

Copyright by Eunyoung Park 2007 - The University of Texas at Austin

FIGURE 2.1. RETINOL

FIGURE 2.1. RETINOL INHIBITS THE GROWTH OF ATRA-RESISTANT HUMAN COLON CANCER CELLS 31

FIGURE 2.1. RETINOL INHIBITS THE GROWTH OF ATRA-RESISTANT HUMAN COLON CANCER CELLS. HCT-15 (A) HCT-116 (B), SW620 (C), and WiDr (D) cells were seeded and treated with 0, 0.1, 1 or 10 μM ATRA or retinol. All treatments were performed in duplicate. Cells were counted via hemocytometer daily for four days. Results represent the mean ± SE for three experiments. Panels in the left column display the percent growth inhibition exhibited by human colon cancer cell lines after 96 h of treatment with increasing amounts of ATRA or retinol. Statistical analysis was performed using t-tests comparing ATRA to retinol for each concentration. *Indicates significantly different from ATRA, P < 0.05. Panels in the right column show the growth rates of HCT-15 (A), HCT-116 (B), SW620 (C) and WiDr (D) cells grown for four days with increasing amounts of retinol. 32

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