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IPS e.max Ceram Scientific Documentation - ROE Dental Laboratory

IPS e.max Ceram Scientific Documentation - ROE Dental Laboratory

Scientific Documentation IPS e.max ® Ceram Page 18 of 21 5.10 University of Freiburg, Germany Head of study: Prof. Strub, Albert-Ludwigs-University, Freiburg Title: Five-year prospective clinical examination of posterior bridges made of an experimental lithium disilicate ceramic Objective: To examine the clinical performance of lithium disilicate based restorations veneered with IPS e.max Ceram. Experimental: Forty three-unit posterior bridges fabricated of IPS e.max CAD and veneered with IPS e.max Ceram were incorporated. Results: The restorations have been commended for their accuracy of fit and aesthetic appearance. No failures have been reported in cases where the minimum dimensions stipulated for the connectors were observed. No chipping of veneering ceramic has been reported to date. 5.11 Conclusions The performance of IPS e.max Ceram was examined in conjunction with lithium disilicate (IPS e.max Press and CAD), zirconium oxide (IPS e.max ZirCAD) and IPS e.max ZirPress in both in vitro investigations and clinical studies. The veneering material has proved itself in clinical applications. It offers many possibilities of creating aesthetic reconstructions and this has met with the approval of the examiners. The parameters specified in the Instructions for Use have to be observed to ensure the reliability and long-term clinical success of these restorations.

Scientific Documentation IPS e.max ® Ceram Page 19 of 21 6. Biocompatibility 6.1 Introduction All-ceramic materials are known for their high levels of biocompatibility 5,6 . The main ingredients of IPS e.max Ceram (SiO2, K2O, ZnO, ZrO2, Li2O, CaO, Na2O, Al2O3) are the same as those of the IPS Eris for E2 ceramic materials, which have been successfully used in clinical applications for many years. Hence, it can be assumed that IPS e.max Ceram offers the same high levels of biocompatibility as these materials. 6.2 Chemical durability Dental materials are exposed to a wide spectrum of pH-values and temperatures in the oral environment. Consequently, high chemical durability is an essential requirement of any dental material. According to Anusavice 7 , ceramic materials are among the most durable dental materials. The in-house laboratory determined the chemical durability of IPS e.max Ceram according to the relevant test prescribed by ISO 6872 as well as in a test using artificial saliva: Test Chemical solubility [µg/cm 2 ] Limit value [µg/cm 2 ] According to ISO 6872 10 - 20 < 100 In artificial saliva 15 – 24 -- (Ivoclar Vivadent AG, Schaan, 2005) � The chemical solubility of IPS e.max Ceram is far lower than the maximum level permitted by the relevant standard. 6.3 In vitro cytotoxicity IPS e.max Ceram comprises the same ingredients as the IPS Eris for E2 veneering materials. Hence, it can be concluded that IPS e.max Ceram does not have any toxic potential. The in vitro toxicity of IPS Eris for E2 was determined in previous investigations: The in vitro toxicity was tested by NIOM, the Scandinavian Institute of Dental Materials, Haslum, Norway by means of a direct cell contact test. The test was conducted according to ISO 10993-5: Biological evaluation of medical devices Part 5: Tests for in vitro cytotoxicity. No cytotoxic potential has been observed under the given test conditions 8 . 6.4 Sensitization, irritation Cavazos 9 , Henry et al. 10 and Allison et al. 11 demonstrated that dental ceramics – unlike other dental materials – do not induce a negative response when they come into contact with the oral mucous membrane. Mitchell 12 as well as Podshadley and Harrison 13 showed that glazed ceramics, which were used in implant-based trials, caused only very mild inflammatory reactions and had a far less irritating effect than other accepted dental materials, such as gold and composite resin.

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