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WELCOME TO THE 2011 - Harvard Initiative for Global Health ...

WELCOME TO THE 2011 - Harvard Initiative for Global Health ...

WELCOME

WELCOME TO THE 2012 NEW ENGLAND TUBERCULOSIS SYMPOSIUM The purpose of the New England TB Symposium is to bring together people interested in any and all aspects of tuberculosis and mycobacterial research and to showcase areas of active investigation. New England boasts the highest density of TB-focused research in the country. Ongoing work spans molecular and genetic epidemiology, TB genomics, epigenetics and metabolism, high-throughput chemical biology, lipid biochemistry, immunology, diagnostics, vaccinology, implementation research, and much more. All investigators and lines of research are welcome at the symposium and we hope you will submit an abstract to present next year! A special area of focus in this year’s symposium is drug resistance with an emphasis on mechanisms, epidemiology, and policy. Our goal is to bring together international leaders in this area with investigators from all over New England to both update the community about the current state of drug resistance research and jumpstart discussions about how we might individually and collaboratively move the field forward. We will additionally highlight a broader spectrum of ongoing work from New England groups interested in tuberculosis. We acknowledge generous support from the Harvard Global Health Institute, the Harvard University Center for AIDS Research, the Harvard School of Public Health, and the Broad Institute. We hope you enjoy today’s symposium and hope to see you again next year! - The New England TB Symposium Planning Committee CONTENTS Welcome ..…………..…………………………………..….……….…1 Agenda …………..…………………………………..….……….…….2 Keynote Speaker Information ………………………..….……….….4 Local Speaker Abstracts and Biographies ………..….……….……6 Winning Poster Abstracts and Presenter Biographies .……….…12 Poster Abstracts ………………….………………….….……….…..15 Participant List ………………………….....……………….………...34 New England TB Symposium Policies ……………..….………..…38 Acknowledgements …………………………………..….………..…39 1

SIXTH ANNUAL NEW ENGLAND TUBERCULOSIS SYMPOSIUM Agenda 8:00 – 8:40am: Breakfast & Registration 8:40 – 8:45am: Welcome: Tracy Rosebrock, Ph.D. and David Gregory, Ph.D. 8:45 – 10:05am: Local speakers: Mycobacteriology and Host Immunology Moderators: Tracy Rosebrock, Ph.D., & David Gregory, Ph.D. 8:45 – 9:05am: “Super-bugs? Strain Based Differences in the Evolution of Drug Resistance.” Chris Ford, B.S., Harvard School of Public Health (PI: Sarah Fortune) 9:05 – 9:25am: “Translation Machinery Phosphorylation and Alternative Ribosomal Proteins in Mycobacterium tuberculosis.” Sladjana Prisic, Ph.D., Children’s Hospital (PI: Bob Hussan) 9:25 – 9:45am: “A Chemical Genetic Approach to Identifying Essential Functions in Non-Replicating Mycobacterium tuberculosis.” Sarah Grant, M.D., Broad Institute (PI: Deb Hung) 9:45 – 10:05am: “Retro is in – Using Retrogenic Mice to Study CD8+ T Cell Responses during Tuberculosis.” Claudio Nunes Alves, B.Sc., Brigham and Women’s Hospital (PI: Sam Behar) 10:05 – 10:30am: Invited Speaker I: Khisimuzi Mdluli, Ph.D., TB Alliance. “Developing Novel Regimens with Reduced Treatment Durations for Drug- Sensitive and Drug-Resistant Tuberculosis.” 10:30 – 10:50am: Coffee Break 10:50 – 11:15am: Invited Speaker II: Scott Podolsky, M.D., Harvard Medical School. “The Politicization of Antibiotic Resistance, 1948-2012.” 11:15am – 12:00pm: Poster Abstract Winners’ Short Talks Moderator: Sladjana Prisic, Ph.D. 11:15 – 11:30am: “Oxidative Escape of Mycobacterium tuberculosis from Neutrophil Killing.” Björn Corleis, Ph.D., London School of Hygiene and Tropical Medicine (PI: Ulrich Schaible) 11:30 – 11:45am: “Nitric Oxide Controls Tuberculosis Immunopathology by Inhibiting NLRP3 Inflammasome-Dependent IL-1� Processing.” Bibhuti Mishra, Ph.D., University of Massachusetts Medical School (PI: Chris Sassetti) 11:45am – 12:00pm: “Using Comparative Lipidomics to Identify New Virulence Factors of Mycobacterium tuberculosis.” Emilie Layre, Ph.D., Brigham and Women’s Hospital (PI: Branch Moody) 12:00 – 1:30pm: Poster Session and Lunch 2

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