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WELCOME TO THE 2011 - Harvard Initiative for Global Health ...

WELCOME TO THE 2011 - Harvard Initiative for Global Health ...

1:30 – 2:20pm: Invited

1:30 – 2:20pm: Invited speaker III: Rob Warren, Ph.D., Stellenbosch University, Cape Town. “Deciphering the Epidemiology of Drug-Resistant Tuberculosis through Comparative Genomics.” 2:20 – 3:20pm: Local speakers: Epidemiology and Diagnostics Moderators: Chris Ford & Karen Kieser 2:20 – 2:40pm: “Construction and Evaluation of an M(X)DR-TB Multiplex Assay using LATE-PCR & Thermalight Probes.” Lisa Rice, B.S., Brandeis University (PI: Lawrence Wangh) 2:40 – 3:00pm: “Evolution of Drug-Resistant Tuberculosis: Results of Whole Genome Tests for Natural Selection.” Maha Farhat, M.D., Massachusetts General Hospital (PI: Megan Murray) 3:00 – 3:20pm: “Aggregate Reports Mask Spatial Clustering of Drug- Resistant Tuberculosis.” Helen Jenkins, Ph.D., Harvard School of Public Health (PI: Ted Cohen) 3:20 – 3:40pm: Coffee Break 3:40 – 4:30pm: Invited Speaker IV: Zarir Udwadia, M.D., P.D., Hunduja National Hospital, Mumbai. “Totally Drug-Resistant Tuberculosis in India: Challenges and Opportunities.” 4:30 – 5:30pm: Panel Discussion: “Totally Drug-Resistant TB is here: Are we too late?” Barry Bloom, Ph.D., Harvard School of Public Health (Chair); Sarah Fortune, M.D., Harvard School of Public Health; Jeremy Greene, M.D., Ph.D., Harvard Medical School; Bob Horsburgh, Ph.D., Boston University; Khisimuzi Mdluli, Ph.D., TB Alliance; Scott Podolsky, M.D., Harvard Medical School; Zarir Udwadia, M.D., Hunduja National Hospital, Mumbai; and Rob Warren, Ph.D., Stellenbosch University, Cape Town A topical discussion to answer how we have arrived at TDR; to discuss new drugs in the pipeline; to consider the ethical and policy considerations surrounding patient treatment; to predict the spread of TDR; and to mobilize our community to devise a strategy to cure people infected with TDR TB. 5:30 – 6:30pm: Reception 3

KEYNOTE SPEAKER INFORMATION Dr. Rob Warren Deciphering the epidemiology of drug-resistant tuberculosis through comparative genomics Biography: Professor Rob Warren continues to focus on the disease dynamics of the M. tuberculosis epidemic in Southern Africa. His current research focuses on: 1) the disease dynamics of drug-sensitive and M(X)DR-TB, 2) the development of novel diagnostics which are applicable to the developing world, 3) discovery of the mechanisms whereby drug resistance develops, 4) speciation of mycobacteria causing disease in humans and animals, 5) application of novel methods to improve the speed of diagnosing smear-positive disease, 5) host-pathogen compatibility, 6) identification of highly pathogenic strains of M. tuberculosis, 7) pathogen evolution and 8) mycobacterial epigenetics. Dr. Zarir F. Udwadia Totally drug-resistant tuberculosis in India: challenges and opportunities Biography: Dr. Zarir F. Udwadia is a consultant chest physician at the Hinduja Hospital, Breach Candy Hospital and Parsee General Hospitals, Mumbai. He is an MD, DNB, FRCP (London.), and FCCP (USA). A post-graduate of the Grant Medical College, Bombay, he spent 5 years training in various centers of excellence in the UK, including Sir John Crofton's former TB unit in Edinburgh and the prestigious Brompton Hospital, London. On his return he established an active chest department at the Hinduja Hospital, a tertiary referral center in Mumbai. He has a special interest and expertise in drug-resistant tuberculosis. About 7000 patients pass through his busy OPD annually, a number of whom are MDR-TB patients referred by colleagues from different parts of the country. Tuberculosis remains his over-riding passion. He has been invited to lecture on Tuberculosis in several countries, including guest orations before the British Thoracic society, ERS, and the Royal Society of Medicine in London. He was invited to deliver the inaugural lecture on “Tackling MDR and XDR-TB in resource-limited settings: India.” at the Gordon TB drug discovery conference, Oxford, UK in 2009. He was the only Indian invited by WHO to be on the “Guidelines Group.” This group after meetings in Paris formulated the 4 th edition of the TB Guidelines, published by WHO in 2010. His group was the first to publish data on survival of a large cohort of Indian MDR-TB patients treated on an OPD basis at the Hinduja Hospital. His group was also the first to report Fluoroquinolone-resistant TB and XDR-TB from India. His recent publication of the first Indian patients with Totally Drug-Resistant TB attracted intense media and medical interest from across the globe. He was invited by WHO to Geneva in March 2012, to be part of the technical group to determine the most appropriate nomenclature and treatment for these patients. He has over 70 PubMed-indexed publications to his credit and his book on "Principles of Respiratory Medicine" has just been published (2011) by Oxford International Publishers. He is actively involved in ongoing TB research collaborations with partners from across the globe. Some of these projects involve new TB diagnostics (with colleagues at the Imperial 4

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