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Nanobacteria to Promote Degenerative Aortic Valve ... - icr-heart.com

Nanobacteria to Promote Degenerative Aortic Valve ... - icr-heart.com

Nanobacteria to Promote Degenerative Aortic Valve ... -

Nanobacteria to Promote Degenerative Aortic Valve Stenosis? Cornelia Piper, Jens Dreier 1 , Knut Kleesiek 1 , Reiner Körfer 2 , Dieter Horstkotte Department of Cardiology, 1 Institute of Laboratory and Transfusion Medicine, 2 Department of Thoracic and Cardiovascular Surgery, Heart Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany Jelic and co-workers submitted the case of an 87year-old female patient with degenerative aortic valve stenosis (AVS), in whom nanobacteria were demonstrated in the fibrocalcific nodules of the aortic cusps by transmission electron microscopy (1). These authors earlier reported a case of mitral valve calcification in a diabetic patient with renal failure, where nanobacteria Address for correspondence: Cornelia Piper MD, Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstr. 11, D-32545 Bad Oeynhausen, Germany e-mail: akohlstaedt@hdz-nrw.de The Journal of Heart Valve Disease 2006;15:499-501 were also speculated to be causative (2). Nanobacteria, like Bartonella spp. and Brucella spp., are very small (3), slow-growing, Gram-negative proteobacteria (3) that produce slime in order to increase their chances of survival in a colony (4). Nanobacteria have been demonstrated in many human degenerative tissues (4-8). Thus, nanobacteria may also play a role in Table I: Characteristics of 20 consecutive patients who had valve replacement for severe, degenerative aortic valve stenosis. Patient Gender Age AVA/ Calcium Concomitant TEM PCR no. (years) BSA score procedure 1 M 74 0.35 2 CAD 0 0 2 F 72 0.30 3 AR 0 0 3 F 75 0.33 2 - 0 0 4 M 81 0.29 2 - 0 0 5 M 76 0.46 1 CAD 0 0 6 F 84 0.34 2 AR 0 0 7 F 73 0.24 3 0 0 8 M 79 0.36 2 CAD, AR 0 0 9 F 87 0.41 3 MR 0 0 10 F 83 0.27 2 - 0 0 11 M 71 0.33 2 CAD 0 0 12 M 87 0.24 3 CAD 0 0 13 F 89 0.26 1 AR 0 0 14 F 72 0.24 3 - 0 0 15 M 82 0.44 3 AR 0 0 16 F 90 0.37 3 - 0 0 17 M 59 0.31 3 CAD 0 0 18 F 76 0.38 1 AR 0 0 19 F 84 0.29 2 CAD 0 0 20 M 88 0.31 3 - 0 0 Mean 78.9 ± 0.326 ± 2.30 ± (± SD) 7.3 0.064 0.73 AR: Aortic regurgitation; AVA/BSA: Aortic valve opening area per body surface area; CAD: Coronary artery disease; MR: Mitral regurgitation PCR: Nanobacterial DNA demonstrated by PCR; TEM: Demonstration of nanobacteria by transmission electron microscopy. © Copyright by ICR Publishers 2006

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