Views
5 years ago

A Textbook of Clinical Pharmacology and Therapeutics

A Textbook of Clinical Pharmacology and Therapeutics

• pulmonary,

• pulmonary, retroperitoneal and pericardial fibrotic reactions have been associated with the ergot-derived dopamine agonists (bromocriptine, cabergoline, lisuride and pergolide). APOMORPHINE Apomorphine is a powerful dopamine agonist at both D1 and D2 receptors, and is used in patients with refractory motor oscillations (on–off phenomena). It is difficult to use, necessitating specialist input. The problems stem from its pharmacokinetics and from side effects of severe nausea and vomiting. The gastrointestinal side effects can be controlled with domperidone. Apomorphine is started in hospital after pretreatment with domperidone for at least three days, and withholding other antiparkinsonian treatment at night to provoke an ‘off’ attack. The subcutaneous dose is increased and when the individual dose requirement has been established, with reintroduction of other drugs if necessary, administration is sometimes changed from intermittent dosing to subcutaneous infusion via a syringe pump, with patient-activated extra boluses if needed. Apomorphine is extensively hepatically metabolized and is given parenterally. The mean plasma t1/2 is approximately 30 minutes. CATECHOL-O-METHYL TRANSFERASE INHIBITORS Use Tolcapone and entacapone are used for adjunctive therapy in patients who are already taking L-dopa/dopa decarboxylase inhibitor combinations with unsatisfactory control (e.g. end-ofdose deterioration). These agents improve symptoms with less on–off fluctuations, as well as reducing the levodopa dose requirement by 20–30%. Adverse effects arising from increased availability of L-dopa centrally can be minimized by decreasing the dose of levodopa combination treatment prospectively. Because of hepatotoxicity associated with tolcapone it is only used by specialists when entacapone is ineffective as an adjunctive treatment. Mechanism of action Reversible competitive inhibition of COMT, thereby reducing metabolism of L-dopa and increasing its availability within nigrostriatal nerve fibres. It is relatively specific for central nervous system (CNS) COMT, with little effect on the peripheral COMT, thus causing increased brain concentrations of L-dopa, while producing less of an increase in plasma concentration. Adverse effects These include the following: • nausea, vomiting, diarrhoea and constipation; • increased levodopa-related side effects; • neuroleptic malignant syndrome; • dizziness; • hepatitis – rare with entacapone, but potentially lifethreatening with tolcapone (liver function testing is mandatory before and during treatment); • urine discolouration. PARKINSON’S SYNDROME AND ITS TREATMENT 127 Pharmacokinetics Tolcapone is rapidly absorbed and is cleared by hepatic metabolism. At recommended doses it produces approximately 80–90% inhibition of central COMT. Drug interactions Apomorphine is metabolized by O-methylation, so interaction with COMT inhibitors is to be anticipated. COMT inhibitors should not be administered with MAOIs, as blockade of both pathways of monoamine metabolism simultaneously has the potential to enhance the effects of endogenous and exogenous amines and other drugs unpredictably. MONOAMINE OXIDASE INHIBITORS – TYPE B SELEGILINE AND RASAGILINE Use Initial small controlled studies in Parkinson’s disease reported that disease progression was slowed in patients treated with selegiline alone, delaying the need to start levodopa. Largerscale studies have not confirmed this conclusion. MAO type B inhibitors, such as selegiline and rasagiline, may be used in conjunction with levodopa to reduce end-of-dose deterioration. Mechanism of action There are two forms of monoamine oxidase (MAO), namely type A (substrates include 5-hydroxytryptamine and tyramine) and type B (substrates include phenylethylamine). MAO-B, is mainly localized in neuroglia. MAO-A metabolizes endogenous adrenaline, noradrenaline and 5-hydroxytryptamine, while the physiological role of MAO-B is unclear. Both isoenzymes metabolize dopamine. Inhibition of MAO-B raises brain dopamine levels without affecting other major transmitter amines. Because selegiline and rasagiline selectively inhibit MAO-B, they are much less likely to produce a hypertensive reaction with cheese or other sources of tyramine than non-selective MAOIs, such as phenelzine. Adverse effects Selegiline is generally well tolerated, but side effects include the following: • agitation and involuntary movements; • confusion, insomnia and hallucinations; • nausea, dry mouth, vertigo; • peptic ulceration. Pharmacokinetics Oral selegiline is well absorbed (100%), but is extensively metabolized by the liver, first to an active metabolite, desmethylselegiline (which also inhibits MAO-B) and then to amphetamine and metamphetamine. Its plasma t1/2 is long (approximately 39 h). Drug interactions At very high doses (six times the therapeutic dose), MAO-B selectivity is lost and pressor responses to tyramine are

128 MOVEMENT DISORDERS AND DEGENERATIVE CNS DISEASE potentiated. Hypertensive reactions to tyramine-containing products (e.g. cheese or yeast extract) have been described, but are rare. Amantadine and centrally active antimuscarinic agents potenti-ate the anti-parkinsonian effects of selegiline. Levodopa-induced postural hypotension may be potentiated. DRUGS AFFECTING THE CHOLINERGIC SYSTEM MUSCARINIC RECEPTOR ANTAGONISTS Use Muscarinic antagonists (e.g. trihexyphenidyl, benzatropine, orphenadrine, procyclidine) are effective in the treatment of parkinsonian tremor and – to a lesser extent – rigidity, but produce only a slight improvement in bradykinesia. They are usually given in divided doses, which are increased every two to five days until optimum benefit is achieved or until adverse effects occur. Their main use is in patients with parkinsonism caused by antipsychotic agents. Mechanism of action Non-selective muscarinic receptor antagonism is believed to restore, in part, the balance between dopaminergic/cholinergic pathways in the striatum. Key points Treatment of Parkinson’s disease • A combination of levodopa and a dopa-decarboxylase inhibitor (carbidopa or benserazide) or a dopamine agonist (e.g. ropinirole) are standard first-line therapies. • Dopamine agonists and COMT inhibitors (e.g. entacapone) are helpful as adjuvant drugs for patients with loss of effect at the end of the dose interval, and to reduce ‘on–off’ motor fluctuations. • The benefit of early treatment with an MAO-B inhibitor, selegiline, to retard disease progression is unproven, and it may even increase mortality. • Polypharmacy is almost inevitable in patients with longstanding disease. • Ultimately, disease progression requires increasing drug doses with a regrettable but inevitable increased incidence of side effects, especially involuntary movements and psychosis. • Anticholinergic drugs reduce tremor, but dose-limiting CNS side effects are common, especially in the elderly. These drugs are first-line treatment for parkinsonism caused by indicated (essential) antipsychotic drugs. Adverse effects These include the following: • dry mouth, blurred vision, constipation; • precipitation of glaucoma or urinary retention – they are therefore contraindicated in narrow angle glaucoma and in men with prostatic hypertrophy; • cognitive impairment, confusion, excitement or psychosis, especially in the elderly. Pharmacokinetics Table 21.1 lists some drugs of this type that are in common use, together with their major pharmacokinetic properties. SPASTICITY Table 21.1: Common muscarinic receptor antagonists, dosing and pharmacokinetics Spasticity is an increase in muscle tone, for example, due to damage to upper motor neurone pathways following stroke or in demyelinating disease. It can be painful and disabling. Treatment is seldom very effective. Physiotherapy, limited surgical release procedures or local injection of botulinum toxin (see below) all have a role to play. Drugs that reduce spasticity include diazepam, baclofen, tizanidine and dantrolene, but they have considerable limitations. Diazepam (see Chapter 18, Hypnotics and anxiolytics) facili-tates γ-aminobutyric acid (GABA) action. Although spasticity and flexor spasms may be diminished, sedating doses are often needed to produce this effect. Baclofen facilitates GABA-B receptors and also reduces spasticity. Less sedation is produced than by equi-effective doses of diazepam, but baclofen can cause vertigo, nausea and hypotension. Abrupt withdrawal may precipitate hyperactivity, convulsions and autonomic dysfunction. There is specialist interest in chronic administration of low doses of baclofen intrathecally via implanted intrathecal cannulae in selected patients in order to maximize efficacy without causing side effects. Dantrolene (a ryanodine receptor antagonist) is generally less useful for symptoms of spasticity than baclofen because muscle power is reduced as spasticity is relieved. It is used intravenously to treat malignant hyperthermia and the neuroleptic malignant syndrome, for both of which it is uniquely effective (see Chapter 24). Its adverse effects include: • drowsiness, vertigo, malaise, weakness and fatigue; • diarrhoea; • increased serum potassium levels. Drug Route of Half-life (hours) Metabolism and Special features administration excretion Trihexyphenidyl Oral 3–7 Hepatic Orphenadrine Oral 13.7–16.1 Hepatic-active Central metabolite stimulation Procyclidine Oral 12.6 Hepatic

  • Page 2 and 3:

    A Textbook of Clinical Pharmacology

  • Page 4 and 5:

    A Textbook of Clinical Pharmacology

  • Page 6 and 7:

    This fifth edition is dedicated to

  • Page 8 and 9:

    FOREWORD viii PREFACE ix ACKNOWLEDG

  • Page 10 and 11:

    PREFACE Clinical pharmacology is th

  • Page 12 and 13:

    PART I GENERAL PRINCIPLES

  • Page 14 and 15:

    ● Use of drugs 3 ● Adverse effe

  • Page 16 and 17:

    and acquired factors, notably disea

  • Page 18 and 19:

    100 Effect (%) 0 0 5 10 1 10 100 (a

  • Page 20 and 21:

    Dose ratio -1 100 50 The relationsh

  • Page 22 and 23:

    ● Introduction 11 ● Constant-ra

  • Page 24 and 25:

    In reality, processes of eliminatio

  • Page 26 and 27:

    lood (from which samples are taken

  • Page 28 and 29:

    ● Introduction 17 ● Bioavailabi

  • Page 30 and 31:

    ROUTES OF ADMINISTRATION ORAL ROUTE

  • Page 32 and 33:

    Transdermal absorption is sufficien

  • Page 34 and 35:

    FURTHER READING Fix JA. Strategies

  • Page 36 and 37:

    and thromboxanes are CYP450 enzymes

  • Page 38 and 39:

    and lorazepam. Some patients inheri

  • Page 40 and 41:

    Orally administered drug Parenteral

  • Page 42 and 43:

    ● Introduction 31 ● Glomerular

  • Page 44 and 45:

    ACTIVE TUBULAR REABSORPTION This is

  • Page 46 and 47:

    DISTRIBUTION Drug distribution is a

  • Page 48 and 49:

    Detailed recommendations on dosage

  • Page 50 and 51:

    DIGOXIN Myxoedematous patients are

  • Page 52 and 53:

    ● Introduction 41 ● Role of dru

  • Page 54 and 55:

    25 20 10 Life-threatening toxicity

  • Page 56 and 57:

    ● Introduction 45 ● Harmful eff

  • Page 58 and 59:

    vagina in girls in their late teens

  • Page 60 and 61:

    an anti-analgesic effect when combi

  • Page 62 and 63:

    Case history A 20-year-old female m

  • Page 64 and 65:

    METABOLISM At birth, the hepatic mi

  • Page 66 and 67:

    lifelong effects as a result of tox

  • Page 68 and 69:

    DISTRIBUTION Ageing is associated w

  • Page 70 and 71:

    DIGOXIN Digoxin toxicity is common

  • Page 72 and 73:

    FURTHER READING Dhesi JK, Allain TJ

  • Page 74 and 75:

    Factors involved in the aetiology o

  • Page 76 and 77:

    analgesic. Following its release, t

  • Page 78 and 79:

    antibiotics, such as penicillin or

  • Page 80 and 81:

    predisposes to non-immune haemolysi

  • Page 82 and 83:

    ● Introduction 71 ● Useful inte

  • Page 84 and 85:

    Response Therapeutic range Toxic ra

  • Page 86 and 87:

    Table 13.1: Interactions outside th

  • Page 88 and 89: Table 13.5: Competitive interaction
  • Page 90 and 91: ● Introduction: ‘personalized m
  • Page 92 and 93: Table 14.2: Variations in drug resp
  • Page 94 and 95: lipoprotein (LDL) is impaired. LDL
  • Page 96 and 97: Key points • Genetic differences
  • Page 98 and 99: • Discovery • • Screening Pre
  • Page 100 and 101: Too many statistical comparisons pe
  • Page 102 and 103: ETHICS COMMITTEES Protocols for all
  • Page 104 and 105: Table 16.1: Recombinant proteins/en
  • Page 106 and 107: duration and benefit. Adenoviral ve
  • Page 108 and 109: ● Introduction 97 ● Garlic 97
  • Page 110 and 111: A case report has suggested a possi
  • Page 112 and 113: including hypericin and pseudohyper
  • Page 114 and 115: PART II THE NERVOUS SYSTEM
  • Page 116 and 117: ● Introduction 105 ● Sleep diff
  • Page 118 and 119: and daytime sleeping should be disc
  • Page 120 and 121: Key points • Insomnia and anxiety
  • Page 122 and 123: Box 19.1: Dopamine theory of schizo
  • Page 124 and 125: The Boston Collaborative Survey ind
  • Page 126 and 127: Oral medication, especially in liqu
  • Page 128 and 129: e.g. interpersonal difficulties or
  • Page 130 and 131: Partial response to first-line trea
  • Page 132 and 133: Key points Drug treatment of depres
  • Page 134 and 135: Case history A 45-year-old man with
  • Page 136 and 137: Levodopa PRINCIPLES OF TREATMENT IN
  • Page 140 and 141: CHOREA The γ-aminobutyric acid con
  • Page 142 and 143: Cholinergic crisis Treatment of mya
  • Page 144 and 145: ● Introduction 133 ● Mechanisms
  • Page 146 and 147: absolute arbiter. The availability
  • Page 148 and 149: Table 22.2: Metabolic interactions
  • Page 150 and 151: FURTHER ANTI-EPILEPTICS Other drugs
  • Page 152 and 153: Case history A 24-year-old woman wh
  • Page 154 and 155: Assessment of migraine severity and
  • Page 156 and 157: ● General anaesthetics 145 ● In
  • Page 158 and 159: is the theoretical concern of a ‘
  • Page 160 and 161: • Respiratory system - apnoea fol
  • Page 162 and 163: Competitive antagonists (vecuronium
  • Page 164 and 165: have also proved useful in combinat
  • Page 166 and 167: ● Introduction 155 ● Pathophysi
  • Page 168 and 169: ASPIRIN (ACETYLSALICYLATE) Use Anti
  • Page 170 and 171: Key points Drugs for mild pain •
  • Page 172 and 173: increases, correlating with the hig
  • Page 174 and 175: • If possible, use oral medicatio
  • Page 176 and 177: PART III THE MUSCULOSKELETAL SYSTEM
  • Page 178 and 179: ● Introduction: inflammation 167
  • Page 180 and 181: Chapter 33). All NSAIDs cause wheez
  • Page 182 and 183: • Stomatitis suggests the possibi
  • Page 184 and 185: Pharmacokinetics Allopurinol is wel
  • Page 186 and 187: PART IV THE CARDIOVASCULAR SYSTEM
  • Page 188 and 189:

    ● Introduction 177 ● Pathophysi

  • Page 190 and 191:

    esponsible for the strong predilect

  • Page 192 and 193:

    Ezetimibe Fat Muscle Dietary fat In

  • Page 194 and 195:

    educed). The risk of muscle damage

  • Page 196 and 197:

    ● Introduction 185 ● Pathophysi

  • Page 198 and 199:

    Each of these classes of drug reduc

  • Page 200 and 201:

    AT 1 receptor) produce good 24-hour

  • Page 202 and 203:

    Table 28.2: Examples of calcium-cha

  • Page 204 and 205:

    Key points Drugs used in essential

  • Page 206 and 207:

    Case history A 72-year-old woman se

  • Page 208 and 209:

    Assess risk factors Investigations:

  • Page 210 and 211:

    Persistent ST segment elevation Thr

  • Page 212 and 213:

    Mechanism of action GTN works by re

  • Page 214 and 215:

    Because of the risks of haemorrhage

  • Page 216 and 217:

    Intrinsic pathway XIIa XIa the acti

  • Page 218 and 219:

    that the pharmacodynamic response i

  • Page 220 and 221:

    used with apparent benefit in acute

  • Page 222 and 223:

    ● Introduction 211 ● Pathophysi

  • Page 224 and 225:

    The drugs that are most effective i

  • Page 226 and 227:

    therapeutic plasma concentration ca

  • Page 228 and 229:

    ● Common dysrhythmias 217 ● Gen

  • Page 230 and 231:

    BASIC LIFE SUPPORT CARDIOPULMONARY

  • Page 232 and 233:

    arrest. The electrocardiogram is li

  • Page 234 and 235:

    should be given to insertion of an

  • Page 236 and 237:

    Drug interactions Amiodarone potent

  • Page 238 and 239:

    effect when treating sinus bradycar

  • Page 240 and 241:

    Case history A 24-year-old medical

  • Page 242 and 243:

    PART V THE RESPIRATORY SYSTEM

  • Page 244 and 245:

    CHAPTER 33 THERAPY OF ASTHMA, CHRON

  • Page 246 and 247:

    STEP 5: CONTINUOUS OR FREQUENT USE

  • Page 248 and 249:

    Adenylyl cyclase Table 33.1: Compar

  • Page 250 and 251:

    Drug interactions Although synergis

  • Page 252 and 253:

    use in asthma has declined consider

  • Page 254 and 255:

    α 1-antitrypsin deficiency, neutro

  • Page 256 and 257:

    PART VI THE ALIMENTARY SYSTEM

  • Page 258 and 259:

    ● Peptic ulceration 247 ● Oesop

  • Page 260 and 261:

    PEPTIC ULCERATION 249 • With rega

  • Page 262 and 263:

    Ranitidine has a similar profile of

  • Page 264 and 265:

    Vestibular stimulation ? via cerebe

  • Page 266 and 267:

    cortical centres affecting vomiting

  • Page 268 and 269:

    • in hepatocellular failure to re

  • Page 270 and 271:

    Ciprofloxacin is occasionally used

  • Page 272 and 273:

    withdrawal), small doses of benzodi

  • Page 274 and 275:

    Table 34.7: Dose-independent hepato

  • Page 276 and 277:

    ● Introduction 265 ● General ph

  • Page 278 and 279:

    dinucleotide (NAD) and nicotinamide

  • Page 280 and 281:

    Table 35.1: Common trace element de

  • Page 282 and 283:

    PART VII FLUIDS AND ELECTROLYTES

  • Page 284 and 285:

    ● Introduction 273 ● Volume ove

  • Page 286 and 287:

    Key points Diuretics Diuretics are

  • Page 288 and 289:

    is sometimes caused by drugs, notab

  • Page 290 and 291:

    or with potassium-sparing diuretics

  • Page 292 and 293:

    Greger R, Lang F, Sebekova, Heidlan

  • Page 294 and 295:

    PART VIII THE ENDOCRINE SYSTEM

  • Page 296 and 297:

    ● Introduction 285 ● Pathophysi

  • Page 298 and 299:

    in prefilled injection devices (‘

  • Page 300 and 301:

    Metformin should be withdrawn and i

  • Page 302 and 303:

    FURTHER READING American Diabetes A

  • Page 304 and 305:

    deficiency. Potassium iodide (3 mg

  • Page 306 and 307:

    fertility. It is contraindicated du

  • Page 308 and 309:

    ● Introduction 297 ● Vitamin D

  • Page 310 and 311:

    effective in life-threatening hyper

  • Page 312 and 313:

    Further reading Block GA, Martin KJ

  • Page 314 and 315:

    Table 40.1: Actions of cortisol and

  • Page 316 and 317:

    injection may be useful, but if don

  • Page 318 and 319:

    CHAPTER 41 REPRODUCTIVE ENDOCRINOLO

  • Page 320 and 321:

    elease by the pituitary via negativ

  • Page 322 and 323:

    Treatment with depot progestogen in

  • Page 324 and 325:

    infusion using an infusion pump to

  • Page 326 and 327:

    significant proportion of men who r

  • Page 328 and 329:

    with symptoms caused by the release

  • Page 330 and 331:

    FURTHER READING Birnbaumer M. Vasop

  • Page 332 and 333:

    PART IX SELECTIVE TOXICITY

  • Page 334 and 335:

    ● Principles of antibacterial che

  • Page 336 and 337:

    2. transfer of resistance between o

  • Page 338 and 339:

    Pharmacokinetics Absorption of thes

  • Page 340 and 341:

    Mechanism of action Macrolides bind

  • Page 342 and 343:

    asic quinolone structure dramatical

  • Page 344 and 345:

    Case history A 70-year-old man with

  • Page 346 and 347:

    PRINCIPLES OF MANAGEMENT OF MYCOBAC

  • Page 348 and 349:

    Pharmacokinetics Absorption from th

  • Page 350 and 351:

    MYCOBACTERIUM LEPRAE INFECTION Lepr

  • Page 352 and 353:

    POLYENES AMPHOTERICIN B Uses Amphot

  • Page 354 and 355:

    therapy is adequate though more fre

  • Page 356 and 357:

    NUCLEOSIDE ANALOGUES ACICLOVIR Uses

  • Page 358 and 359:

    Table 45.3: Summary of available ac

  • Page 360 and 361:

    Uses Interferon-α when combined wi

  • Page 362 and 363:

    ● Introduction 351 ● Immunopath

  • Page 364 and 365:

    Table 46.1: Examples of combination

  • Page 366 and 367:

    NON-NUCLEOSIDE ANALOGUE REVERSE TRA

  • Page 368 and 369:

    FUSION INHIBITORS Uses Currently, e

  • Page 370 and 371:

    salvage therapy include azithromyci

  • Page 372 and 373:

    ● Malaria 361 ● Trypanosomal in

  • Page 374 and 375:

    Pharmacokinetics Chloroquine is rap

  • Page 376 and 377:

    Table 47.2: Drug therapy of non-mal

  • Page 378 and 379:

    ● Introduction 367 ● Pathophysi

  • Page 380 and 381:

    Table 48.1: Classification of commo

  • Page 382 and 383:

    Polymorph count/mm 3 (a) (b) 10 000

  • Page 384 and 385:

    doses are used to prepare patients

  • Page 386 and 387:

    Adverse effects Methotrexate Inhibi

  • Page 388 and 389:

    Table 48.7: Summary of clinical pha

  • Page 390 and 391:

    Table 48.9: Summary of the clinical

  • Page 392 and 393:

    Plasma membrane Signal transduction

  • Page 394 and 395:

    Table 48.10: Monoclonal antibodies

  • Page 396 and 397:

    INTERFERON-ALFA 2B Interferon-alfa

  • Page 398 and 399:

    PART X HAEMATOLOGY

  • Page 400 and 401:

    ● Haematinics - iron, vitamin B 1

  • Page 402 and 403:

    one marrow to produce red cells. Th

  • Page 404 and 405:

    EPO Erythroid precursors Erythrocyt

  • Page 406 and 407:

    Therapeutic principles The extent o

  • Page 408 and 409:

    PART XI IMMUNOPHARMACOLOGY

  • Page 410 and 411:

    ● Introduction 399 ● Immunity a

  • Page 412 and 413:

    Key points Antigen recognition Expr

  • Page 414 and 415:

    Table 50.1: Novel anti-proliferativ

  • Page 416 and 417:

    Key points Treatment of anaphylacti

  • Page 418 and 419:

    DRUGS THAT ENHANCE IMMUNE SYSTEM FU

  • Page 420 and 421:

    PART XII THE SKIN

  • Page 422 and 423:

    ● Introduction 411 ● Acne 411

  • Page 424 and 425:

    DERMATITIS (ECZEMA) PRINCIPLES OF T

  • Page 426 and 427:

    SPECIALISTS ONLY SPECIALISTS ONLY E

  • Page 428 and 429:

    TREATMENT OF OTHER SKIN INFECTIONS

  • Page 430 and 431:

    effect of too high a dose of UVB in

  • Page 432 and 433:

    PART XIII THE EYE

  • Page 434 and 435:

    ● Introduction: ocular anatomy, p

  • Page 436 and 437:

    to cause pupillary dilatation, name

  • Page 438 and 439:

    Table 52.3: Antibacterial agents us

  • Page 440 and 441:

    Table 52.6: Common drug-induced pro

  • Page 442 and 443:

    PART XIV CLINICAL TOXICOLOGY

  • Page 444 and 445:

    ● Introduction 433 ● Pathophysi

  • Page 446 and 447:

    Table 53.2: Central nervous system

  • Page 448 and 449:

    which provide anonymized data to th

  • Page 450 and 451:

    Peak plasma levels after smoking ci

  • Page 452 and 453:

    Key points Acute effects of alcohol

  • Page 454 and 455:

    FURTHER READING Goldman D, Oroszi G

  • Page 456 and 457:

    Table 54.2: Common indications for

  • Page 458 and 459:

    Table 54.5: Antidotes and other spe

  • Page 460 and 461:

    Commission on Human Medicines (CHM)

  • Page 462 and 463:

    Note: Page numbers in italics refer

  • Page 464 and 465:

    atrial fibrillation 217, 221 digoxi

  • Page 466 and 467:

    Cushing’s syndrome 302 cyclic ade

  • Page 468 and 469:

    5-fluorouracil 375-6 fluoxetine, mo

  • Page 470 and 471:

    children 54 diazepam 108 iron prepa

  • Page 472 and 473:

    non-steroidal anti-inflammatory dru

  • Page 474 and 475:

    puberty (male), delay 314 puerperiu

  • Page 476:

    tolerance 9, 433 benzodiazepines 10

A-Textbook-of-Clinical-Pharmacology-and-Therapeutics-5th-edition
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
World Journal of Gastrointestinal Pharmacology and Therapeutics
Experience In Using PBPK Models in Clinical Pharmacology Reviews
ReadOnline Soliman s Auricular Therapy Textbook: New Localizations and Evidence Based Therapeutic Approaches M.D. Nader Soliman PreOrder
Diagnosis and pharmacological management of Parkinson's - SIGN
Role of Quantitative Clinical Pharmacology in Guiding Drug
Prescribing and Pharmacology of Controlled Drugs: Critical Issues ...
An Anatomico-Clinical Overview - Advances in Clinical ...
NEWS - The Journal of Clinical Endocrinology & Metabolism
2012 EDUCATIONAL BOOK - American Society of Clinical Oncology
HIV/AIDS Treatment and Care : Clinical protocols for the European ...
A textbook of pharmacology and therapeutics, or, The action of ...
CLINICAL PHARMACOLOGY AND THERAPEUTICS FOR THE ...
O - Journal of Pharmacology and Experimental Therapeutics
Pharmacology and therapeutics, clinical trial - Dermage
O - Journal of Pharmacology and Experimental Therapeutics
B - Journal of Pharmacology and Experimental Therapeutics