Wellness Foods + Supplements 3/2023

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages.

Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.


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No. 3, November/December <strong>2023</strong><br />

www.harnisch.com | ISSN 2364-8104<br />

Photo © : Adobe Stock/Mediteraneo<br />

Women's health<br />

Probiotics<br />

Dairy products<br />

Marine ingredients<br />

Vitamins<br />

Healthy ageing<br />

Energy and endurance<br />

Plant extracts






SNACKS<br />

International Trade Fair for Savoury Snacks & Nuts<br />



19-20 JUNE 2024<br />


TRENDS<br />

TASTES<br />








Editorial<br />

SILKE WATKINS, Editor-in-Chief<br />

Are we losing touch with nature?<br />

Today’s generation of grandparents have not<br />

only spent more time experiencing nature,<br />

they also know more about the various plant<br />

and animal species and are well versed in<br />

the healing power of herbs and plants. Not<br />

that everything used to be better in the good<br />

old days. But when it comes to nature, that<br />

is actually true. Technology and digitalisation<br />

now take up so much space in our lives<br />

that there is very little room left for experiencing<br />

nature.<br />

A distinct estrangement from nature among<br />

children and adolescents began back at<br />

the end of the 1990s. 60 per cent of the<br />

people interviewed found it unpleasant to<br />

have a bug crawl over their hand. 36 per<br />

cent were unable to recall a beautiful experience<br />

of nature. Sadly, this situation has not<br />

improved. There is a connection between<br />

experiences in nature and media consumption.<br />

62 per cent of adolescents who rarely<br />

go out into the woods spend three or more<br />

hours in front of a screen every day. This<br />

figure is only 45 per cent among adolescents<br />

who spend time in the woods almost daily.<br />

Back in 1990, a survey showed that nearly<br />

three quarters of all children between 6 and<br />

13 years of age were spending time outside<br />

every day. This was true for less than half the<br />

children in 2003.<br />

We know that regular experiences in nature<br />

support children’s overall development,<br />

including their sense of balance, body confidence,<br />

maturing of the senses, social skills,<br />

cognitive abilities, language, imagination and<br />

overall health. Brain research has found that<br />

the presence of nature, interacting with and playing in it, is relevant for<br />

satisfying emotional as well as cognitive needs of people as they grow<br />

up. When children are denied these experiences, they have difficulty<br />

developing key abilities. Their emotional bonding capacity becomes<br />

stunted without proximity to plants and animals. The empathy, imagination<br />

and zest for life of the children decline.<br />

When parents are asked why they do not allow their children to have<br />

these experiences, the answer is often: Fear. Fear that the children<br />

may get hurt outdoors, that they may become ill through contact<br />

with plants and animals. Many children internalise the views of their<br />

parents that are passed on to them. Dangers and diseases are seen<br />

to be lurking everywhere. These children are however robbed of the<br />

opportunity to experience the meaning of life. Their vitality is taken<br />

from them. Cognition researchers view this as the primary cause of<br />

psychological illnesses.<br />

Estrangement from nature has significant potential to be disastrous<br />

for civilisation. Who is to preserve nature when there is nobody left<br />

with awareness that it forms part of our lives? That it provides us with<br />

everything we need to lead a good and healthy life?<br />

Schools, too, largely limit themselves to imparting information. Topics<br />

pertaining to nature are of course included in the curriculum, and<br />

students gain an awareness of nature. But that is the crux of the<br />

matter: While children and adolescents learn about the composition<br />

of animals and plants, this learning is theoretical and detached from<br />

life. Young people are not truly experiencing anything when they go<br />

to parks, but are not allowed to touch anything there and have to stay<br />

on designated trails. They need opportunities for contact with nature,<br />

to freely experience it with all their senses and to give their creativity<br />

free rein. Even though it may be difficult for many people today, this<br />

always includes an element of risk. But that’s life.<br />

I wish you an interesting read!<br />

Silke Watkins<br />

No. 3 November/December <strong>2023</strong><br />


Contents<br />

Health<br />

Convenience Food<br />

Food & Beverages<br />

Confectionary<br />

Cover Photo © : Adobe Stock/Mediteraneo<br />

Various studies increasingly indicate that nutrition during<br />

prenatal and early childhood development in particular can<br />

have a decisive and formative influence on the later development<br />

of obesity, type 2 diabetes mellitus and cardiovascular<br />

disease. This means that someone will be healthy or ill<br />

in old age, is laid out in the early phase of life and can be<br />

strongly influenced by environmental factors. For example,<br />

an un balanced diet can lead to changes in development as<br />

early as the embryonic phase and into the first years of life.<br />

These changes can even be passed down through generations.<br />

However, this also means that external factors are much more<br />

decisive for health than genes. The mother's eating habits<br />

and the child's subsequent diet in the first few years of life<br />

can therefore have significant consequences for the child. This<br />

naturally continues as the child grows older.<br />

(see articles on pages: 10, 12, 16, 19, 27, 42)<br />

Sports Nutrition<br />

Health Care<br />

Contents<br />

Personal Care<br />

Women's health<br />

06 Menobelle TM , living through the menopause comfortably<br />

08 Arjuna Natural’s turmeric – Frankincense botanical blend relieves menstrual pain in clinical study<br />

Probiotics<br />

10 Food probiotics, add a pinch of healthy<br />

Gut health<br />

12 “Prebiocran - The new generation of gut health solutions”<br />

Dairy products<br />

16 How can we rethink food products and adapt them to the world we live in?<br />

Natural marine complex<br />

19 Perspectives in osteoporosis therapy: The unique contribution of salmon-based CalGo ®<br />

Vitamins<br />

22 Moringa: Multivitamin with high protein content<br />

Botanical extracts<br />

24 Botanical extracts: the natural solution to flavourists’ technical and organoleptic requirements<br />

Natural plant extracts<br />

27 Why does Pycnogenol ® offer such a wide range of health benefits?<br />

Energy drinks<br />

33 “Caffeine alone is not enough”: Reinventing the ‘energy drink’ for a modern lens<br />

Sweetening alternatives<br />

36 Date derivatives as a special sweetening alternative<br />

38 Ticking the boxes for sweetness and improved nutritional properties<br />

Healthy ageing<br />

42 Spermidine science: unlocking the secrets to healthy ageing<br />

Energy and endurance<br />

46 Equipping the body to push harder for longer<br />

Obituary<br />

50 Au Revoir Edouard<br />

50 Impressum<br />

4 No. 3 November/December<strong>2023</strong>

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Women's health<br />

Photo © : Adobe Stock/Ivan Traimak<br />

Menobelle TM , living through the<br />

menopause comfortably<br />

Women have to address any number of specific issues throughout<br />

their lives, but tackling physical concerns and the desire to age<br />

happily and healthily are major priorities. Menopause is one of these<br />

issues and is associated with personal challenges and changes in<br />

personal roles within the family and society. Committed to improving<br />

women’s well-being, Robertet has developed Menobelle, a solution<br />

to live through the menopause comfortably.<br />

This upcycled ingredient containing lemon balm, bergamot and<br />

peony relieves the physical and mental discomforts of menopause.<br />

It can be easily used in food supplements or functional foods and its<br />

efficiency has been proven with clinical studies.<br />

Menopause, a key stage in women’s health<br />

The women’s health market continues to grow. Indeed, the annual<br />

growth rate of the global market is estimated at 12.4 % over the<br />

period 2020-2030 1 . Femtech startups worldwide have invested and<br />

raised a record of 2.6 billion euros, up 44% from 2020 2 .<br />

Menopause is a natural event in a woman’s life. For 85 % of women,<br />

this phenomenon is also associated to physical and emotional<br />

changes that can strongly affect their everyday life. 3 With an estimation<br />

of 9.7 billion people in 2050, and an aging population 4 , the<br />

number of menopausal women is set to rise. Numerous challenges<br />

are being launched on the market to meet women’s needs.<br />

Menobelle a new active for women's health<br />

Menobelle is an ingredient that accompanies women during menopause<br />

to target physical and mental changes. This natural ingredient<br />

is composed of a blend of synergistic Mediterranean plants, without<br />

hormones or phyto-oestrogens compared to some ingredients on the<br />

market.<br />

– Menobelle is composed of Melissa officilalis, a plant of Robertet<br />

sourcing extracted from fresh leaves. This plant improves sleep,<br />

mood, cognitive health, digestion and bloating.<br />

– Citrus bergamia, supplied thanks to a long-standing partnership<br />

with Robertet, also enters in the ingredient’s composition. It targets<br />

cardio-metabolic disorders.<br />

– The third plant is Paeonia lactiflora which has analgesic and antispasmodic<br />

properties to fight against menopausal disorders.<br />

Beyond the natural character of the ingredient, Menobelle matches<br />

with the sustainability trend, as it is upcycled.<br />

This ingredient offers an effective solution that women can trust. A clinical<br />

study was carried out on 153 pre-menopausal and menopausal<br />

women aged 45 to 55. With two capsules of Menobelle, two times<br />

a day, during two months, the ingredient had relieved menopausal<br />

discomforts. Indeed, Menobelle had decreased many menopausal<br />

symptoms: hot flushes, night sweats, need for solitude, dissatisfac-<br />

6 No. 3 November/December <strong>2023</strong>

Women's health<br />

tion with work life, stomach pain, fatigue, sexual desire reduction,<br />

lack of energy, physical changes, irritability... The results had been<br />

proven from the second month. The ingredient, in the form of a beige<br />

to yellow powder, is not soluble in water. It can be easily used in food<br />

supplements or functional foods. The optimal dose is 475 mg/day.<br />

With its plant-based composition, it is suitable for vegans.<br />

The following claims can be used for the ingredient: Menobelle<br />

relieves menopausal discomfort, including mental and physical wellbeing.<br />

Robertet is aware of the problems women face throughout<br />

their lives, especially menopause.<br />

Robertet, a partner in women’s health<br />

Robertet, committed to improving women’s well-being, expresses its<br />

desire to support women at every stage of life, with the development<br />

of a range of ingredients whose reliability and efficacy have been<br />

proven by scientific studies.<br />

– Among these ingredients, Lipowheat targets a glowing and<br />

younger-looking skin.<br />

– Holimel ® also plays a role in skin beauty, and particularly in the skin<br />

photoaging protection.<br />

– To help reduce cellulite, Dimpless ® has been developed.<br />

– And Robertet doesn’t stop here: Keranat acts on the anti-hair<br />

loss solution to enhance hair beauty. With many ingredients<br />

designed to improve women’s quality of life, Robertet is deep into<br />

the women’s health.<br />

References<br />

1<br />

Women Health and Beauty <strong>Supplements</strong> Market, by Ingredient Application, Distribution<br />

Channel : Global Opportunity Analysis and Indutry Forecast, 2021-2030<br />

2<br />

CB Insights, La carte du marché Femtech, 2021<br />

3<br />

Robertet, Menobelle, living through the menopause comfortably<br />

4<br />

United Nations, Global Issues, Population.<br />

For more information, please visit<br />

www.robertet.com<br />

No. 3 November/December <strong>2023</strong><br />


Women's health<br />

Photo © : Adobe Stock/New Africa<br />

Arjuna Natural’s turmeric – Frankincense botanical<br />

blend relieves menstrual pain in clinical study<br />

A novel botanical formula powered by turmeric (Curcuma<br />

longa L), and frankincense (Boswellia serrata) has demonstrated<br />

abilities to alleviate menstrual cramps in a new clinical<br />

study. Rhuleave-K, a breakthrough blend composed by<br />

the renowned nutraceutical company Arjuna Natural Pvt<br />

Ltd, is poised to offer a natural holistic solution to manage<br />

menstrual discomfort, allowing women to enjoy their daily<br />

activities without interruption.<br />

Primary dysmenorrhea is characterized by intense, and sometimes<br />

excruciating cramping that grips the lower abdomen and pelvic zone.<br />

It emerges right before and during the first couple of days of menstruation<br />

and lasts for about 48 to 72 hours. It can be accompanied by<br />

additional symptoms such as sweating, headache, nausea, vomiting<br />

and diarrhoea.<br />

The burden of menstrual pain is the single most prevalent gynaecological<br />

complaint that affects over half of women in their reproductive<br />

age regardless of age or socioeconomic status. For many, the pain is<br />

so debilitating that it disrupts their daily routine leading to diminished<br />

work productivity, missed days at work or study, reduced sleep quality<br />

with knock-on effects on the overall quality of life for at least several<br />

days each month.<br />

The randomized, double-blinded, placebo-controlled study led by<br />

Dr Divya Agarwal was published in the Journal of Clinical Medicine<br />

in June <strong>2023</strong>. The study which was conducted at the Smt. Meva<br />

Chaudhary Hospital in Jhansi involved healthy women suffering from<br />

primary dysmenorrhea: painful menstruation unrelated to any uterine<br />

pathology. Only women reporting moderate to severe menstrual<br />

cramping were qualified to participate.<br />

8 No. 3 November/December <strong>2023</strong>

Women's health<br />

In a one-day, single-dose study, the cohort of women was randomly<br />

split into two groups. One group was allocated 1000 mg Rhuleave-K<br />

in two soft gels, while the other received a placebo. The participants<br />

were administered their assigned treatments only when the menstrual<br />

pain reached a severity of 5 or greater on a 0–10 numeri cal rating<br />

scale (NRS).<br />

After dosing, the participants were evaluated every 30 minutes for<br />

six hours to track changes in pain intensity and pain relief. Results<br />

indicated a promising role of the turmeric–Boswellia formulation in<br />

reducing pain intensity. The mean total pain relief of the treatment<br />

group was found to be 12.6 times better than the placebo group with<br />

a statistically significant difference at every 30-minute time point.<br />

Moreover, the overall difference in pain intensity following six hours of<br />

observation was 20 times better than the placebo group.<br />

Rhuleave-K is a pioneering formula meticulously crafted by Arjuna<br />

Natural, as a botanical solution for providing pain relief. In this<br />

ground-breaking botanical blend, turmeric and Boswellia extracts are<br />

brought together in an oil base and manufactured using proprietary<br />

SPEEDTECH technology to elicit fast action.<br />

This unique blend has already showcased potent analgesic activity in<br />

numerous clinical trials, specifically targeting musculoskeletal pain.<br />

“The excellent results we witnessed in the previous studies on musculoskeletal<br />

pain inspired us to see if we can extend Rhuleave-K’s benefits<br />

to other common forms of pain,” reports Benny Antony, PhD, joint<br />

managing director for Arjuna Natural. “Menstrual pain is a relentless<br />

burden for countless women globally. Many depend on overthe-counter<br />

NSAIDs to get pain relief. Yet more and more women<br />

are turning to natural therapies as they seek a comprehensive and<br />

enduring solution for menstrual pain relief. Rhuleave-K has the potential<br />

to offer an easy and rapid natural solution to this common issue,<br />

our company is dedicated to empowering women to take control of<br />

their well-being through natural solutions.”<br />

“Additional clinical trials are in the pipeline to further explore<br />

Rhuleave-K potential role in providing fast action menstrual pain<br />

relief and synergistic all-round support,” concludes Antony.<br />

References<br />

“Effect of Turmeric–Boswellia–Sesame Formulation in Menstrual Cramp Pain Associated<br />

with Primary Dysmenorrhea—A Double-Blind, Randomized, Placebo-Controlled Study”,<br />

June <strong>2023</strong><br />

Authors: Divya Agarval, et al.<br />

doi.org/10.3390/jcm12123968<br />

For more information, please visit<br />

https://arjunanatural.com/<br />

No. 3 November/December <strong>2023</strong><br />


Probiotics<br />

Photo © : Adobe Stock/Krakenimages<br />

Food probiotics, add a pinch of healthy<br />

Consumer awareness and demand for healthier ingredients,<br />

especially for probiotics in foodstuffs, is increasing as they<br />

are looking to improve their overall wellbeing. The role of<br />

probiotics to support a healthy and balanced gut microflora<br />

is well documented and known by the consumers; 68 %<br />

of consumers recognize the link between digestive health<br />

and overall health. Hence, functional foods and beverages<br />

containing specific probiotics with health benefits have been<br />

growing as a category around the world.<br />

Functional foods or beverages offer health benefits that extend<br />

beyond their nutritional value. In addition to nutrient-rich ingredients<br />

like fruits and vegetables, the category includes foods fortified with<br />

vitamins, minerals, fiber, and probiotics. 55 % of global consumers<br />

say they prefer to choose foods and beverages that provide functional<br />

benefits and 40 % of global consumers state they are willing to pay up<br />

to 10 % more for foods that provide functional benefits. 1<br />

FMCG GURUS affirms, in their 2022 non-alcoholic beverages<br />

global report, that consumers are nowadays most likely to choose<br />

“better-for-you” beverages that are winning over sugary juices and<br />

colas. Consumers are taking a proactive<br />

approach to health and wellbeing, as<br />

44 % of consumers state they are interested<br />

by pro ducts supporting the immune<br />

system, and 41 % of consumers say they are<br />

appealed by the claim “contains probiotics”.<br />

Overall, 59 % of global consumers state they<br />

have purchased a probiotic product in the<br />

last 12 months.<br />

The challenges of formulating<br />

with probiotics<br />

Probiotics are defined as “live microorganisms<br />

that, when administered in adequate<br />

amounts, confer a health benefit on the<br />

host”. The key aspects of this definition<br />

include that probiotic bacteria must be alive<br />

when administered and be able to survive in<br />

a sufficient amount until they reach their site<br />

of action – the intestinal tract.<br />

10 No. 3 November/December <strong>2023</strong>

Probiotics<br />

Microencapsulated strains<br />

Formulating probiotics in food matrices<br />

comes with challenges, and it takes specific<br />

know-how to incorporate probiotics in food<br />

matrices. The efficacy of probiotics is contingent<br />

to their capacity to survive the many<br />

stressors from the manufacturer’s plant<br />

to the consumer’s gut. Lallemand Health<br />

Solutions has developed a range of protective<br />

technologies to ensure optimal probiotic<br />

survival in food matrices, and efficacy<br />

at their site of action. Probiocap ® technology<br />

is a microencapsulation procedure that<br />

protects probiotic strains from physical food<br />

processing conditions such as compression,<br />

thermal shocks, and high acidity, offering<br />

great opportunities for food applications.<br />

Probiocap ® technology can be applied to the<br />

following strains, which have been extensively<br />

studied in humans either alone or in<br />

combination:<br />

L. helveticus Rosell ® -52<br />

L. rhamnosus Rosell ® -11<br />

B. longum Rosell ® -175<br />

L. helveticus LAFTI ® L10<br />

Spore-forming Bacillus strains<br />

The spore-forming Bacillus probiotic strains<br />

are intrinsically resistant strains. In hostile<br />

conditions, Bacillus probiotics can perform<br />

a specific transformation, called sporulation,<br />

which leads to the formation of an<br />

endospore. When the environment becomes<br />

favorable, the endospore can reactivate itself<br />

into a vegetative cell. Due to the protective<br />

endospore, spore-forming probiotics<br />

are naturally capable of surviving thermal<br />

shocks, high pressure, pH variations, gastric<br />

acidity from digestion and long-term storage.<br />

Photo © : shutterstock/losangela<br />

Their viability and efficacy were successfully<br />

tested in several extreme conditions<br />

for many food and beverage applications.<br />

Bacillus probiotics withstand high pressure<br />

processing and pasteurization, common<br />

manufacturing processes to preserve beverages.<br />

Lallemand’s strain resistance to<br />

pasteurization has notably been tested in<br />

non-dairy milks, namely almond milk and<br />

soy milk and showed great survival. Moreover,<br />

the strain was shown to survive throughout the shelf life of several<br />

kombucha products, despite the low pH environment.<br />

Overall, Bacillus strains have been tested in many food and beverages<br />

applications. Lallemand Health Solutions proposes two sporeforming<br />

probiotic strains: Bacillus subtilis Rosell ® -179 which has identified<br />

mechanism of action for its beneficial effects on gut health and<br />

is documented with one clinical study on bile acid metabolism in overweight,<br />

otherwise healthy, adults. As per its latest addition, Bacillus<br />

coagulans Rosell ® -449 it has demonstrated gut health benefits.<br />

Building on over 85 years of probiotic knowledge and know-how from<br />

its research center, the Rosell ® Institute for Microbiome and Probiotics,<br />

Lallemand Heath Solutions is leveraging functionality for gut<br />

microbiome, and many more health purposes, by offering probiotic<br />

solutions for food and beverage applications such as microencapsulated<br />

Lactobacilli and Bifidobacterium strains and spore forming<br />

Bacillus bacteria. This brings added health solutions to the global food<br />

and beverage market, for gut, immune, mental, women’s, metabolic,<br />

skin, oral health, and the sports category.<br />

Reference<br />

1<br />

FMCG Gurus, 2022<br />

For more information, please contact<br />

foodprobiotics@lallemand.com<br />

foodprobiotics.lallemand.com<br />

No. 3 November/December <strong>2023</strong><br />


Gut health<br />

“Prebiocran - The new generation<br />

of gut health solutions”<br />

It is widely recognized that diet is an essential determinant<br />

of health, and a predominant factor shaping the host-microbiota<br />

relationship. Indeed, gut microbiota contributes to the<br />

energy balance and produces metabolites triggering metabolic<br />

and inflammatory responses in response to various<br />

stimuli such as diet 1 .<br />

In a healthy state, the epithelial cells form a strong barrier protected<br />

by a mucus layer keeping the bacterial community at a safe distance,<br />

while select symbionts favor maturation of the mucosal immune<br />

system by interacting with the host epithelium 1 . However, a growing<br />

body of evidence indicates that western diet, characterized by high-fat,<br />

high sugar, and low fiber content, contributes to the etiology of chronic<br />

inflammatory diseases, and alters the gut microbiota (i. e., dysbiosis),<br />

with harmful consequences on the intestinal barrier and immune function.<br />

This notably leads to what is called a “leaky gut”, i. e., the disruption<br />

of the intestinal barrier, which is associated with alterations of the<br />

gut microbiota, reduction of the mucus layer thickness and consistency,<br />

impairment of the tight junction, microbiota<br />

encroachment, increased permeability<br />

allowing translocation of pathogens and associated<br />

molecules (i. e., endotoxemia) and<br />

inflammation 1,2 .<br />

Fortunately, some nutritional components<br />

like polyphenols emerge as potential dietary<br />

solutions associated with health benefits.<br />

Fruits polyphenols consumption is associated<br />

with reduced risk of chronic diseases,<br />

such as cardiovascular pathologies or metabolic<br />

syndrome 3–5 . These bioactive metabolites<br />

are poorly absorbed in the small intestine<br />

and reach the colon, where they modulate<br />

the gut microbiota and exert a prebio tic 1<br />

effect which is positively associated with<br />

metabolic and gut health 3–5 .<br />

12 No. 3 November/December <strong>2023</strong>

Gut health<br />

Phenobio+ - A 5-year<br />

research program<br />

In 2018, Symrise supported the creation of<br />

a 5-year Industrial Partnership Chair called<br />

Phenobio+, together with the Institute of<br />

Nutrition and Functional <strong>Foods</strong> (INAF)<br />

and the Natural Science and Engineering<br />

Research Council of Canada (NSERC). The<br />

Chair was led by Prof. Yves Desjardins and<br />

aimed to investigate the potential prebiotic<br />

effect of fruit polyphenols, in particular from<br />

cranberry. This unprecedented scientific<br />

program produced cutting-edge research.<br />

The results are the outcome of talented<br />

student’s work guided by Prof. Yves Desjardins,<br />

but also other prominent researchers<br />

involved in the Chair (Prof. André Marette,<br />

Denis Roy, Alain Veilleux and Emile Levy).<br />

prebiotics such as fibers. In the context of the Industrial Partnership<br />

Chair, Symrise aimed to investigate the potential prebiotic impact of<br />

Prebiocran on intestinal barrier function and potential metabolic<br />

health benefits. A systemic approach used a clinical study, some<br />

animal models of metabolic disorders and cell line experiments,<br />

and advanced in vitro models, such as intestinal organoids and the<br />

M-SHIME, one the few gut models that artificially mimics the entire<br />

gastrointestinal tract. The results showed that Prebiocran modulates<br />

the gut microbiota composition and function, which is associated<br />

with metabolic health improvement.<br />

Prebiocran modulates the gut microbiota beta-diversity<br />

In a short-term clinical trial, 39 healthy participants daily consumed<br />

480 mg of Prebiocran for 4 days. A 7-day washout period preceded<br />

the intervention, with strict limitation of polyphenols-containing food.<br />

Biological samples were collected before and after the treatment and<br />

fecal DNA has been sequenced to study the gut microbiota evolution.<br />

Symrise and cranberry: a long history<br />

Cranberry (Vaccinium macrocarpon) is a<br />

fruit originating from North America, rich in<br />

polyphenols and traditionally used by Native<br />

Americans to relieve a variety of ailments.<br />

Symrise expertise in the processing and<br />

extraction of cranberry polyphenols started<br />

back in 2008. Thanks to its dedicated extraction<br />

facility located in the Quebec province<br />

of Canada, in the heart of the cranberry<br />

production area, the company has a unique<br />

access to local cranberry farmers and carefully<br />

selects the most concentrated in polyphenols<br />

varieties.<br />

Prebiocran - Symrise's polyphenolrich<br />

cranberry extract<br />

Cranberries are high in polyphenols, having<br />

antioxidant properties and supporting<br />

various health benefits of which urinary but<br />

also cardiometabolic health. Prebiocran is<br />

a natural ingredient obtained by extracting<br />

the phenolic compounds of cranberries.<br />

It has been designed to offer all the varieties<br />

of polyphenols present in the fruit and<br />

is standardized to feature no less than 30 %<br />

total polyphenols (Folin-Ciocalteu method).<br />

Prebiocran is a low-dose (480 mg) offering<br />

convenient on-the-go supplement formats<br />

that cannot be formulated with traditional<br />

Prebiocran treatment modulates the human microbiota in a clinical study.<br />

Lessard-Lord et al., unpublished. The distance-based redundancy analysis<br />

based on 16S RNAr gene amplicon sequencing exhibits the dissimilarity between<br />

the subjects. Each dot represents a unique human subject microbiota<br />

before (in blue) and after (in purple) 4 days of Prebiocran treatment.<br />

The results of this clinical trial showed that a short-term administration<br />

of Prebiocran was sufficient to modulate the basal human gut<br />

microbiota beta-diversity, and to notably induce a bloom of Bifidobacterium,<br />

a bacteria associated with gut health 7 (Lessard-Lord et al.,<br />

unpublished).<br />

This modulation of the gut microbiota was also observed in the<br />

M-SHIME ® complex in vitro model. The Simulator of the Human<br />

Intestinal Microbial Ecosystem (SHIME ® ) is one of the few gut models<br />

that mimics the entire gastrointestinal tract. It is a semi-dynamic<br />

model with multi-stage compartment reactors, each of them respec-<br />

No. 3 November/December <strong>2023</strong><br />


Gut health<br />

tively displaying defined conditions (pH, nutritional medium etc.)<br />

according to the intestinal region they represent, following a longitudinal<br />

axis. The M-SHIME, i. e., Mucosal-SHIME, is an extension<br />

of this model which also mimics the mucosal microbiome, incorporating<br />

mucin-covered microcosms and allowing better understanding<br />

of the host-microbe interaction according to the transversal axis 8,9 .<br />

In this study (Cattero et al., unpublished), researchers inoculated<br />

the M-SHIME system with the fecal material of six healthy subjects.<br />

After a suitable adaptation period, they administrated 480 mg Prebiocran<br />

for two weeks. Then, they analyzed the gut microbiota<br />

composition and showed that, consistent with the clinical study,<br />

Prebiocran significantly and gradually modulated the microbiota<br />

composition in all the gut compartments (lumen and mucus of the<br />

ascendant and transverse colons). More specifically, Prebiocran<br />

promoted, in both lumen and mucin compartments of the transverse<br />

colon, the growth of bacteria known to metabolize proanthocyanidins<br />

(PACs) into smaller bioactive metabolites (i. e., Eggerthella, Flavonifactor<br />

and Lactiplantibacillus) 10,11 , but also bacteria associated with<br />

gut barrier protection and health, such as Akkermansia and Faecalibacterium<br />

12,13 .<br />

Finally, these results were also confirmed by in vivo models in a<br />

longer term. Most of the preclinical studies were performed using<br />

diet-induced obesity and type 2 diabetes mouse models. Mice<br />

received either a control diet, a high-fat high-sugar (HFHS) diet or a<br />

high-fat high sugar diet supplemented with Prebiocran for 14-19<br />

weeks 14,15 . Interestingly, all the animal studies converged with the clinical<br />

and M-SHIME studies and repeatedly showed that Prebiocran<br />

modulates the gut microbiota 14–16 . This was often associated with the<br />

increase of Akkermansia genus 14 .<br />

Prebiocran and cranberry extract fractions support<br />

gut barrier function<br />

Alongside with these previous investigations, the researchers also<br />

studied the capacity of cranberry extracts to support the gut barrier<br />

function in several models.<br />

To understand underlying mechanisms and involved functions,<br />

in-depth investigations in the M-SHIME ® model specifically showed<br />

that Prebiocran not only increased some individual bacteria, but<br />

a consortium or a guild of bacteria. This was associated with health<br />

benefits, enhancing a favorable ecosystem and health relatedmetabo<br />

lites production such as butyrate and specific bile acids<br />

(Cattero and Lessard-Lord et al., unpublished).<br />

Also, mouse organoids were used to mimic a mini intestine, as a<br />

complex multicellular in vitro system. Researchers reproduced the<br />

model published by O’Rourke and al. 17 , which presents the main<br />

types of intestinal barrier cells (i.e., Paneth cells, enterocytes, Goblet<br />

cells and enteroendocrine cells). Results showed that a fraction of<br />

Prebiocran, purified in proanthocyanidins (PACs), time and dosedependently<br />

increases Muc2 and Klf4 gene<br />

expression, some key biomarkers of intestinal<br />

strengthening involved in Goblet cells differentiation<br />

and mucin production (Tinoco-Mar<br />

et al., unpublished).<br />

Moreover, additional results in the same<br />

previously described obesity and type 2<br />

diabetes mouse studies highlighted the<br />

capacity of Prebiocran to improve the gut<br />

health barrier function and metabolic health,<br />

supporting its prebiotic potential. Indeed,<br />

Anhê et al. observed a prevention of the endotoxemia<br />

(i. e., high level of lipopolysaccharides<br />

in blood circulation – also a marker of<br />

intestinal permeability) and several markers<br />

of jejunum inflammation such as increased<br />

Cox2, TNFα or NF-κB gene expression 14 .<br />

Medina-Larqué et al. also showed that Prebiocran<br />

prevented the deleterious effects<br />

of the HFHS diet on the intestinal barrier<br />

strength, counteracting the decrease of<br />

crypt depth, Goblet cells (mucin producers)<br />

number and mucus degradation 16 . Finally,<br />

in a model where mice were already obese<br />

after 13 weeks of HFHS diet, Prebiocran<br />

administration tended to restore the mucin<br />

amount present in feces 18 .<br />

Prebiocran sustains<br />

metabolic health<br />

In a classic model of Caco-2/15 intestinal<br />

cells, researchers evaluated the beneficial<br />

impact of a PACs-rich cranberry fraction<br />

on inflammation, oxidation, lipid, and<br />

glucose homeostasis. It was observed that<br />

this fraction from Prebiocran was effective<br />

in counteracting the decrease of antioxidant<br />

defense (SOD2) and oxidative stress (COX2)<br />

markers in intestinal cells. Also, the extract<br />

prevented the increase of several lipogenesis<br />

(SREBP-1C), neoglucogenesis (G6P) and<br />

insulin signaling (pAkt) markers.<br />

Finally, researchers also tested in murine<br />

models the potential beneficial preventive<br />

effects of Prebiocran on obesity-associated<br />

disorders, such as type 2 diabetes and<br />

hepatic steatosis. Anhê et al. and Daoust<br />

et al. notably observed that the cranberry<br />

extract prevented the HFHS-induced metabolic<br />

damages, in particular the liver weight<br />

14 No. 3 November/December <strong>2023</strong>

Gut health<br />

gain and the hepatic lipid accumulation, as<br />

well as the hyperinsulinemia and the Homeostasis<br />

Model Assessment of Insulin Resistance<br />

(HOMA-IR) index increase 14,15 .<br />

Overall, the results of Symrise’s partnership<br />

with INAF demonstrate the role of<br />

Prebiocran in supporting gut and metabolic<br />

health at a low dose of 480 mg.<br />

References<br />

1. Régnier, M., Hul, M. V., Knauf, C. & Cani, P. D. Gut microbiome, endocrine control of gut barrier function and metabolic<br />

diseases. Journal of Endocrinology 248, R67–R82 (2021).<br />

2. Daniel, N., Lécuyer, E. & Chassaing, B. Host/microbiota interactions in health and diseases—Time for mucosal microbiology!<br />

Mucosal Immunology 14, 1006–1016 (2021).<br />

3. Fraga, C. G., Croft, K. D., Kennedy, D. O. & Tomás-Barberán, F. A. The effects of polyphenols and other bioactives on<br />

human health. Food Funct. 10, 514–528 (2019).<br />

4. Crowe-White, K. M. et al. Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline. Adv Nutr 13,<br />

2070–2083 (2022).<br />

5. Vivarelli, S. et al. Polyphenols: a route from bioavailability to bioactivity addressing potential health benefits to tackle<br />

human chronic diseases. Arch Toxicol 97, 3–38 (<strong>2023</strong>).<br />

6. Gibson, G. R. et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics<br />

(ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14, 491–502 (2017).<br />

7. Chen, J., Chen, X. & Ho, C. L. Recent Development of Probiotic Bifidobacteria for Treating Human Diseases. Front Bioeng<br />

Biotechnol 9, 770248 (2021).<br />

8. Molly, K., Vande Woestyne, M. & Verstraete, W. Development of a 5-step multi-chamber reactor as a simulation of the<br />

human intestinal microbial ecosystem. Appl Microbiol Biotechnol 39, 254–258 (1993).<br />

9. Van de Wiele, T., Van den Abbeele, P., Ossieur, W., Possemiers, S. & Marzorati, M. The Simulator of the Human Intestinal<br />

Microbial Ecosystem (SHIME ® ). in The Impact of Food Bioactives on Health: in vitro and ex vivo models (eds. Verhoeckx, K.<br />

et al.) (Springer, 2015).<br />

10. Corrêa, T. A. F., Rogero, M. M., Hassimotto, N. M. A. & Lajolo, F. M. The Two-Way Polyphenols-Microbiota Interactions and<br />

Their Effects on Obesity and Related Metabolic Diseases. Front Nutr 6, 188 (2019).<br />

11. Gaur, G. & Gänzle, M. G. Conversion of (poly)phenolic compounds in food fermentations by lactic acid bacteria: Novel<br />

insights into metabolic pathways and functional metabolites. Current Research in Food Science 6, 100448 (<strong>2023</strong>).<br />

12. Cani, P. D., Depommier, C., Derrien, M., Everard, A. & de Vos, W. M. Akkermansia muciniphila: paradigm for next-generation<br />

beneficial microorganisms. Nat Rev Gastroenterol Hepatol 19, 625–637 (2022).<br />

13. Leylabadlo, H. E. et al. The critical role of Faecalibacterium prausnitzii in human health: An overview. Microbial Pathogenesis<br />

149, 104344 (2020).<br />

14. Anhê, F. F. et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal<br />

inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64, 872–883<br />

(2015).<br />

15. Daoust, L. et al. The postnatal window is critical for the development of sex-specific metabolic and gut microbiota<br />

outcomes in offspring. Gut Microbes 13, 2004070 (2021).<br />

16. Medina-Larqué, A.-S. et al. Cranberry polyphenols and agave agavins impact gut immune response and microbiota<br />

composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet.<br />

Front Immunol 13, 871080 (2022).<br />

17. O’Rourke, K. P., Ackerman, S., Dow, L. E. & Lowe, S. W. Isolation, Culture, and Maintenance of Mouse Intestinal Stem<br />

Cells. Bio Protoc 6, e1733 (2016).<br />

18. Anhê, F. F. et al. A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of<br />

body weight loss. Mol Metab 6, 1563–1573 (2017).<br />

The new<br />

gut health<br />

solution<br />

backed by<br />

a 5-year Chair<br />

of research<br />

For more information, feel free to contact<br />

Symrise at https://www.diana-food.com/contact<br />

Scan to watch<br />

our scientific<br />

video<br />

No. 3 November/December <strong>2023</strong><br />


Dairy products<br />

How can we rethink food products and<br />

adapt them to the world we live in?<br />

Anne Laure LEGRAND<br />

Yogurt-based products are enjoying growing popularity,<br />

thanks to the increasing interest shown by consumers in<br />

fermentation processes and the functional properties associated<br />

with this category. In response, French dairy ingredient<br />

supplier Epi Ingredients has contributed its expertise<br />

develop a yogurt powder set to become a reference in the<br />

market. This product reflects the company’s determination<br />

to meet customer demands with useful innovations offering<br />

numerous benefits.<br />

What do consumers expect today?<br />

Consumer demands are increasingly specific and varied. Since the<br />

Covid-19 crisis, interest in health is particularly strong, and a balanced<br />

nutritious diet is seen as essential for maintaining good health. 1<br />

Compositions are scrutinized for beneficial or innovative elements.<br />

However, the search for improved health has not come to replace the<br />

search for eating pleasure, only to complement it. Flavors are therefore<br />

still of prime importance. It is also interesting<br />

to note that consumers are becoming<br />

increasingly curious about experiencing new<br />

flavors. Indeed, as a sign of increased openmindedness,<br />

an appetite for foreign cuisine<br />

seems to be becoming more and more widespread<br />

around the world.<br />

Against this backdrop, new product launches<br />

and innovations are not uncommon since<br />

the pandemic. In particular, nearly 800<br />

products containing yogurt powder have<br />

been launched in Europe, including 213 in<br />

the last year. 2 This specific market therefore<br />

appears to be dynamic and could remain so<br />

if the demands presented above are taken<br />

as a roadmap for the development of new<br />

products.<br />

16 No. 3 November/December <strong>2023</strong>

Dairy products<br />

Yogurt: a combination of taste<br />

and health<br />

A solid nutritional composition<br />

The nutritional benefits of yogurt - and yogurt<br />

powders - are beyond question. They provide<br />

a significant quantity of nutrients essential to<br />

the body’s proper functioning. In terms of vitamins<br />

and minerals, it contains calcium, B vitamins,<br />

phosphorus, and potassium which are<br />

all involved in biological processes as varied<br />

as they are important. For example, calcium<br />

is essential for maintaining healthy teeth and<br />

bones and minerals are involved in the functions<br />

of the metabolism and blood pressure<br />

regulation. Yogurt powder is also rich in highquality<br />

protein. Indeed, the proteins present<br />

in yogurt contain essential amino acids not<br />

produced in the human body.<br />

Microorganisms: the indispensable<br />

ingredients in yogurt<br />

Yogurt is a dairy product obtained by the<br />

fermentation of milk by certain microorganisms.<br />

These microorganisms must be alive,<br />

active, and present in significant quantities.<br />

The characteristics of yogurt, such as<br />

its texture, flavor and nutritional value, are<br />

precisely those influenced by the microorganisms<br />

selected and the management<br />

of fermentation concentration, temperature<br />

and duration. They are therefore of the<br />

utmost importance.<br />

More specifically, these microorganisms<br />

are lactic acid bacteria. Lactic acid bacteria<br />

are a group of bacteria involved in various<br />

ways in the fermentation process and<br />

some of them are specific to yogurt e. g.,<br />

Streptococcus thermophilus and Lactobacillus<br />

bulgaricus. They possess an enzyme,<br />

B-galactosidase, which breaks down lactose<br />

into simple sugar (glucose and galactose).<br />

This enzyme remains active throughout the<br />

digestive tract, making yogurt powder suitable<br />

for people with lactose intolerance.<br />

Probiotics for better health<br />

Let's give these bacteria another title!<br />

They can also be described as probiotics.<br />

According to the WHO definition, probiotics<br />

are “living microorganisms which,<br />

when ingested in sufficient quantities, exert<br />

a health benefit over and above the traditional nutritional effects”.<br />

This is precisely the case with yogurt and yogurt powder, which can<br />

contain more than 10 7 cfu/g of powder. For sure, a sufficient quantity!<br />

So, what are the benefits of probiotics in yogurt? There is no shortage<br />

of them! They contribute to well-being, nutritional support, improved<br />

transit and lactose digestion.<br />

Yogurt powder: a wide range of applications<br />

Yogurt powder is a dried form of yogurt. One of the main aims of drying<br />

is to preserve it. Yogurt powder has a longer shelf life than fresh yogurt,<br />

and its low moisture content means it does not need to be refrigerated.<br />

Yogurt powder is also very easy to use. Compared with conventional<br />

yogurt, its smaller volume makes it easier to transport, and the fields<br />

of application are wide. Yogurt powders can be used in adult and<br />

baby foods, to make ice creams, drinks, and bakery products, and<br />

in numerous innovations around the world. They can be found, for<br />

example, in pastry fillings and toppings, frozen desserts, seasonings,<br />

yogurt drinks and nutritional products.<br />

In some of these applications, fresh yogurt could not be used. For<br />

example, it is not used in chocolate and confectionery, whereas<br />

yogurt powder can be found in recipes for marshmallows or gums.<br />

Epi Ingredients’ solution: a process to preserve benefits<br />

and ensure quality<br />

Between convenience, proven health benefits and a familiar, appreciated<br />

taste, it is clear that yogurt powder has all the potential to appeal<br />

to consumers. French ingredient supplier Epi Ingredients provides a<br />

complete range of yogurt powders that take into account all the issues<br />

presented here.<br />

Well-preserved benefits<br />

These yogurt powders are produced from skimmed yogurts by a<br />

spray drying process, giving them a shelf life of 9 to 12 months. The<br />

same process is also used to manufacture milk powders.<br />

In setting up this process, careful attention was paid to the microorganisms<br />

that are essential to yogurt. Epi Ingredients’ manufacturing<br />

process has been fine-tuned by solid technical expertise to keep<br />

certain cultures alive throughout the manufacturing process, right<br />

up to the final product obtained. Their effect on texture and health<br />

is thus preserved. In addition, neither the other nutritional benefits<br />

nor the characteristic taste of yogurt is affected. In short, despite the<br />

drying process, there’s no difference with fresh yogurt.<br />

Superior quality, suitable for infants<br />

As mentioned before, the functional benefits of yogurt powders enable<br />

a wide range of applications: e. g., ice creams, beverages, adult nutrition,<br />

bakery products etc. To this list, Epi Ingredients added an application<br />

that requires the utmost attention: infant nutrition.<br />

No. 3 November/December <strong>2023</strong><br />


Dairy products<br />

Thanks to these various controls, Epi Ingredients’ yogurt powders<br />

are of the highest hygienic quality. They can be used in baby foods,<br />

providing the essential elements for their development in complete<br />

safety.<br />

Dynamic products to meet societal demand<br />

Ingredient supplier Epi Ingredients is committed to finding solutions<br />

in line with current consumer trends and expectations. The manufacture<br />

of yogurt powder is therefore adapted to the development of new<br />

products and to strict certifications. This is illustrated by the launch<br />

of new preparations sourced from a diverse blend of cultures as well<br />

as organic and acid yogurt powders.<br />

A new product innovation in response to current trends embracing<br />

cuisine from diverse cultures has recently been developed in powder<br />

form: kefir. Kefir is a drink from the Caucasus with a texture close<br />

to drinking yogurt. It can be consumed as it is or used in recipes to<br />

replace milk or cream.<br />

Epi Ingredients’ first guarantee of quality is manufacturing on an<br />

industrial site that produces infant formula. All yogurt powders are<br />

thus controlled according to strict criteria concerning infant nutrition.<br />

In particular, the environment of the drying towers is highly<br />

controlled: children’s products are monitored with the utmost vigilance,<br />

and microbiological tests are carried out on a regular basis.<br />

Not all microorganisms are harmful to humans, but those that are<br />

must be monitored with the strictest attention. For example, Cronobacter<br />

is a bacterium present in the environment that is transmitted<br />

mainly via food consumption and can therefore be responsible for<br />

human infections. Infants and young children under 5 are particularly<br />

vulnerable targets. Infected by Cronobacter, they can develop<br />

meningitis or septicemia among other things. Cronobacter is therefore<br />

a key concern at the forefront of anti-bacterial controls.<br />

The presence of microorganisms can also give rise to a bacterial<br />

competition mechanism. Placed in the same environment, different<br />

species can enter into competition: sharing the same resource or<br />

secreting toxins can affect their survival and reproduction. In other<br />

words, microorganisms regulate their own development. In yogurt,<br />

the lactic flora of at least 10 7 cfu/g enables this competition mechanism<br />

to take place, naturally limiting the development of undesirable<br />

microorganisms.<br />

Consumer awareness of food quality and the goal of eating better,<br />

healthier food is driving the organic market. Against this backdrop,<br />

Epi Ingredients has made considerable efforts to offer organic yogurt<br />

powders. The result? The strict requirements of organic specifications<br />

are met, while still retaining functional, nutritional, and organoleptic<br />

benefits without the need for refrigeration.<br />

Consumer demands also concern taste. In response, Epi Ingredients<br />

has developed an additive-free sour yogurt powder providing a full<br />

range of traditional, authentic and natural yogurt flavors.<br />

Epi Ingredients’ yogurt powders are thus an ideal example of a<br />

product designed with no compromise on eating pleasure, nutrition,<br />

and health benefits. Their superior quality and strict conformity with<br />

infant nutrition requirements make them a product you can trust.<br />

This is also the perfect illustration of Groupe Laïta's CSR approach<br />

initiated in 2015, Passion du Lait ® . Innovations are designed in<br />

response to societal expectations, with a focus on utility and openness<br />

to the world.<br />

These products and their applications will be presented at<br />

FI Europe <strong>2023</strong>, Booth: 3.0J20.<br />

References<br />

1<br />

Mazars, Les Français et le système de santé, 02/2022<br />

2<br />

Mintel, <strong>2023</strong><br />

For more information, please contact<br />

Anne Laure LEGRAND<br />

Product manager<br />


epi.ingredients@laita.fr<br />

https://epi-ingredients.com/en/<br />

18 No. 3 November/December <strong>2023</strong>

Natural marine complex<br />

Photo © : Hofseth Biocare<br />

Perspectives in osteoporosis therapy: The<br />

unique contribution of salmon-based CalGo ®<br />

Dr. Sonja John<br />

Osteoporosis is a widespread and<br />

serious health problem that affects<br />

millions of people. This disease leads<br />

to a decrease in bone density with an<br />

increased risk of fractures. To address<br />

this challenge, it is crucial to understand<br />

the prevention and treatment<br />

of osteoporosis and explore ways to<br />

promote bone health.<br />

Osteoporosis: a complex disease<br />

The risk of developing osteoporosis varies<br />

across the population. The differences<br />

include gender, age 1 , family predisposition,<br />

diet and other external factors such as<br />

smoking and alcohol consumption 2 . In addition,<br />

certain medications such as glucocorticoids<br />

3 can also increase the risk of osteoporosis.<br />

Compared to men, women have a higher<br />

risk of osteoporosis, due to a lack of estrogen<br />

during the menopause 5 . The risk of developing<br />

osteoporosis increases with age due to natural bone loss; therefore,<br />

elderly women are the most vulnerable group for osteoporosis.<br />

The complexity of the factors that contribute to the development of<br />

this disease demonstrates the importance of targeted measures for<br />

prevention and treatment.<br />

Prevention and early detection: the key to health<br />

The prevention of osteoporosis involves a variety of measures that are<br />

closely linked with diet, exercise and lifestyle.<br />

A diet with sufficient amounts of calcium, vitamin D and vitamin K<br />

plays a decisive role in the early prevention of osteoporosis 4,6 . These<br />

factors are responsible for achieving a high peak bone mass, meaning<br />

the maximum bone density achieved in early adulthood.<br />

In prevention, calcium carbonates and other calcium salts are most<br />

frequently used to improve the dietary supply of calcium 11, 12, 13 .<br />

Calcium carbonate has a very high calcium content compared to<br />

other calcium salts and was therefore often used as the main active<br />

component in food supplements in the past. However, the clini cal<br />

evidence has been questioned by some scientists. Excessive intake of<br />

calcium may lead to negative effects, such as an increased tendency<br />

to arteriosclerosis and the associated risks.<br />

No. 3 November/December <strong>2023</strong><br />


Natural marine complex<br />

Nature has given us the opportunity to utilise<br />

precisely this perfect mixture in the form of<br />

food supplements: literally bones for bones.<br />

The use of a natural complex of calcium,<br />

phosphorus, zinc and collagen has been<br />

shown in scientific studies to be an effective<br />

means of strengthening and supporting an<br />

already damaged bone structure.<br />

Fish as a secret weapon for bone<br />

health<br />

Photo © : Adobe Stock/luciano<br />

Another essential trace element for bone health is zinc. It is involved in<br />

numerous biological processes and promotes bone strength through<br />

the formation of osteoblasts (bone-forming cells) and inhibiting osteoclasts<br />

(bone-degrading cells) at the same time 15 .<br />

In addition to an adequate supply of minerals, collagen is of particular<br />

importance for bone health. Collagen is present in the bones in the<br />

form of collagen fibres and collagen matrix and is responsible for<br />

the structure and strength of bone tissue 9 . Even if osteoporosis is<br />

already present, collagen can support the regeneration process of<br />

the bone structure, as it interacts with various growth factors and thus<br />

promotes bone regeneration and tissue repair 10 .<br />

Fish, especially sea fish, is widely recognised<br />

for its positive health effects. Omega-3<br />

fatty acids and the high-quality protein in fish<br />

meat are often emphasised in this context.<br />

However, fish can contribute so much more<br />

to human health. By utilising the whole fish,<br />

a high-quality basis for food supplements can<br />

be obtained. In Norway, the fish skeletons<br />

from sustainably produced farmed salmon<br />

are carefully processed in accordance with<br />

the highest quality standards. The resulting,<br />

gently produced natural product consists of a<br />

complex of HAP, collagen type II, protein and<br />

zinc as well as other valuable ingredients.<br />

Particularly noteworthy is the marine HAP,<br />

which is obtained from salmon and marketed<br />

under the brand name CalGo ® . This natural<br />

complex is still relatively unknown when<br />

Targeted weight training is also important for the long-term strengthening<br />

of bone substance 8 . Protein supply also has a positive effect on<br />

bone health 7 .<br />

The combination product from nature<br />

A combination of active ingredients that are similar to the bone<br />

structure is a sensible alternative to the well-known sources of<br />

calcium. A closer look at the potentially preventive effects of these<br />

substances suggests that this combination can be used both for the<br />

supportive treatment of osteoporosis and for prevention, with proven<br />

positive effects on bone structure.<br />

Calcium and phosphate are present in the bones in the form of<br />

hydroxyapatite (HAP), a substance that plays a crucial role in maintaining<br />

bone health and strength. Despite the balanced Ca:P ratio,<br />

HAP has rarely been used in the prevention of osteoporosis. Instead,<br />

different combinations of calcium and phosphate are used, as these<br />

are necessary for the formation of hydroxyapatite in bone 13, 14 .<br />

Photo © : Adobe Stock/Jakub Ruthiewicz<br />

20 No. 3 November/December <strong>2023</strong>

Natural marine complex<br />

it comes to preventing osteoporosis and<br />

promoting general bone health. However,<br />

its properties are impressive: the absorption<br />

rate of CalGo ® exceeds that of conventional<br />

calcium carbonate by a factor of six 17 .<br />

Even in cases where the bone structure has<br />

already been damaged, the use of CalGo ®<br />

can help to restore stability. Recent studies<br />

provide convincing results and emphasise<br />

the benefits of this complex, readily bioavailable<br />

compound 16 .<br />

Food supplements for strong bones: The right choice can<br />

make the difference<br />

The prevention and treatment of osteoporosis requires a holistic<br />

approach. The right choice of supplements can have a decisive<br />

impact on bone health. In a world where osteoporosis is a widespread<br />

challenge, natural approaches such as CalGo ® open up new ways to<br />

promote strong and healthy bones. Osteoporosis may be complex,<br />

but the first line of defence can be simple and natural. Bones for<br />

healthy bones.<br />

References<br />

1. McGuigan, F. E., Murray, L., & Gallagher, A. (2011). Body mass index and the risk of fracture. Osteoporosis International, 22(2), 587-592.<br />

2. Berg, K. M., Kunins, H. V., Jackson, J. L., Nahvi, S., Chaudhry, A., Harris, K. A., ... & Arnsten, J. H. (2008). Association between alcohol consumption and<br />

both osteoporotic fracture and bone density. The American Journal of Medicine, 121(5), 406-418.<br />

3. Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000). Use of oral corticosteroids and risk of fractures. Journal of Bone and<br />

Mineral Research, 15(6), 993-1000.<br />

4. Weaver, C. M. (2011). Calcium requirements of physically active people. The American Journal of Clinical Nutrition, 93(3), 545S-555S.<br />

5. Johnell, O., & Kanis, J. A. (2006). An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporosis International,<br />

17(12), 1726-1733.<br />

6. Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281.<br />

7. Darling, A. L., Millward, D. J., Torgerson, D. J., Hewitt, C. E., Lanham-New, S. A., & Berry, J. L. (2009). Dietary protein and bone health: a systematic review<br />

and meta-analysis. The American Journal of Clinical Nutrition, 90(6), 1674-1692.<br />

8. Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E., & Yingling, V. R. (2004). American College of Sports Medicine Position Stand: physical activity<br />

and bone health. Medicine and Science in Sports and Exercise, 36(11), 1985-1996.<br />

9. Saito, M., & Marumo, K. (2010). Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis,<br />

and diabetes mellitus. Osteoporosis International, 21(2), 195-214.<br />

10. Martino, M. M., Briquez, P. S., Güç, E., Tortelli, F., Kilarski, W. W., Metzger, S., ... & Hubbell, J. A. (2014). Growth factors engineered for super-affinity to<br />

the extracellular matrix enhance tissue healing. Science, 343(6173), 885-888.<br />

11. Reid, I. R., Bolland, M. J., & Grey, A. (2010). Effect of calcium supplementation on hip fractures. Osteoporosis International, 21(2), 291-299.<br />

12. Tang, B. M., Eslick, G. D., Nowson, C., Smith, C., & Bensoussan, A. (2007). Use of calcium or calcium in combination with vitamin D supplementation<br />

to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. The Lancet, 370(9588), 657-666.<br />

13. Bristow, S. M., Gamble, G. D., Stewart, A., Horne, L., House, M. E., Aati, O., ... & Reid, I. R. (2015). Acute and 3-month effects of microcrystalline<br />

hydroxyapatite, calcium citrate malate, and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal<br />

women. Osteoporosis International, 26(1), 408-419.<br />

14 Martínez-Maestre, M. Á., González-Cruz, M., & Clavel, J. (2013). Efficacy of hydroxyapatite and a triticum vulgare extract in preventing and treating osteoporosis<br />

in wistar rats. Journal of Osteoporosis, 2013.<br />

15. Yamaguchi, M., Weitzmann, M. N. (2011). Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation.<br />

Molecular and Cellular Biochemistry, 355(1-2), 179-186.<br />

16. Xu, Y., Ye, J., Zhou, D., & Su, L. (2020). Research progress on applications of calcium derived from marine organisms. Scientific reports, 10(1), 18425<br />

17. Currie, C., Framroze, B., Bjerknes, C., & Hermansen, E. (2022). A Randomized, Blinded, Calcium-Carbonate Controlled Cross over Study of Serum<br />

Calcium Levels 24 Hours after CalGotm Oral Supplementation in Post-Menopausal Women. Biomed. J. Sci. Tech. Res, 41, 32581-32585.<br />

For more information, please contact<br />

Dr. Sonja John, Head of Product and<br />

Application Management<br />


No. 3 November/December <strong>2023</strong><br />


Vitamins<br />

Photo © : Adobe Stock/Homesh<br />

Green powder from the Moringa tree<br />

Moringa: Multivitamin<br />

with high protein content<br />

Horseradish tree, drumstick tree and miracle tree are names<br />

for the inconspicuous Moringa tree. It has the reputation<br />

of being one of the most nutrient-rich plants in the world.<br />

Almost all plant components are usable and edible: from the<br />

root to the flowers and seeds to the leaves. Especially the<br />

powder as well as the tablets made from Moringa leaves and<br />

the seed oil find their way onto the European market. Moringa<br />

products are popular because of their ingredients and their<br />

many uses. The Import Promotion Desk (IPD), a project of<br />

the German Federal Minis-try for Economic Cooperation and<br />

Development (BMZ), supports producers of Moringa from<br />

developing and emerging countries, such as Ethiopia, Madagascar<br />

and Sri Lanka, in bringing their products to the EU<br />

market. In turn, IPD connects European buyers with selected<br />

suppliers and opens up alternative procurement sources for<br />

them.<br />

Wonder tree and “Shiferaw”<br />

There are 13 different types of Moringa trees. They belong to the plant<br />

family of the bennut family. The best known and most widespread<br />

is Moringa oleifera. The species originates<br />

from the Indian Himalayan region and is now<br />

cultivated in many tropical areas, including<br />

Africa, South America and Southeast Asia.<br />

Moringa stenopetala is a wild species native<br />

to southern Ethiopia and northern Kenya. It<br />

is often called the African Moringa tree. Both<br />

species do not require a lot of water, are fastgrowing<br />

and can reach up to ten metres in<br />

height.<br />

The Moringa tree has many names: It is<br />

called the horseradish tree because the tree<br />

roots have a pungent horseradish-like aroma<br />

due to the content of mustard oil glycosides.<br />

It is also called the drumstick tree after the<br />

long thin Moringa pods, which resemble<br />

small drumsticks in appearance. Its designation<br />

as a cabbage tree already indicates<br />

that the tree plays an important role in the<br />

diet of the population in southern Ethiopia. In<br />

22 No. 3 November/December <strong>2023</strong>

Vitamins<br />

E thio pia, the Moringa tree is also called “Shiferaw”: the tree that can<br />

be used for more than 1.000 diseases. Furthermore, another name<br />

for it is miracle tree. It has earned this honorary title not only because<br />

of its richness in nutrients, but also because almost all of its parts are<br />

used by the local population as a food or remedy.<br />

Crop plant from the root to the crown<br />

The Moringa tree is a 100 per cent useful plant – from the roots to<br />

the crown of the tree: the root with its horseradish-like flavour is often<br />

used as a condiment. The root and bark are also used medicinally for<br />

internal and external applications. The blossoms of the Moringa tree<br />

can be processed into tea or eaten fresh. An oil rich in unsaturated<br />

fatty acids can be pressed from the Moringa seeds. The fruits of the<br />

Moringa tree, the pods, can also be used in the kitchen. The tase of<br />

the drumstick is said to be reminiscent of asparagus.<br />

Moringa leaves, for example, are traded on the markets in southern<br />

Ethiopia as a nutrient-rich vegetable. They serve as a cabbage substitute<br />

in the local cuisine and can be eaten fresh or cooked. The leaves<br />

are also used to make Moringa powder, which is in high demand on<br />

the European market.<br />

Nutrient bomb: Moringa powder<br />

Moringa leaves have a very high nutrient density. They contain vitamins<br />

A, B and C as well as minerals such as calcium, magnesium<br />

and iron. In addition, the protein content is high and most of the<br />

known essential amino acids are found in the leaves.<br />

Even after the drying process, a high proportion of nutrients is retained.<br />

The IPD partner com-panies in Ethiopia and Madagascar rely on<br />

gentle natural drying to preserve the protein and mineral content of<br />

the Moringa leaves, thus retaining the health-promoting effects of the<br />

Moringa. During the careful drying process on the shelfs, the Moringa<br />

leaves have to be turned daily to achieve even drying, colouring and<br />

to retain their high quality. The leaves come from smallholders or<br />

from the farm itself.<br />

During cultivation and processing, care is taken to ensure that<br />

the leaves are left in their natural state. The companies in the IPD<br />

programme are bio-certified, thus avoiding exposure to pesticides.<br />

The multivitamin with high protein content is offered in powder, tea<br />

and tablet form. The powder tastes slightly spicy and can be used<br />

in many ways. It is very popular in smoothies. But it also goes well<br />

in salad dressings, dips and spreads. Additionally, it can be used<br />

for baking and cooking to enrich hearty dishes with nutrients. Those<br />

who do not like the spiciness of the powder can choose Moringa<br />

tablets. Tea can also be brewed from the leaves. Although vitamins<br />

are broken down by the heat, many other nutrients of the Moringa<br />

leaves are also retained in the tea.<br />

Nutrient mix for the immune system<br />

In Ayurvedic medicine, Moringa is used for a variety of ailments.<br />

Moringa is said to help with up to 300 different conditions. As a<br />

dietary supplement, dried Moringa leaves with their mix of nutrients<br />

can help to strengthen the immune system, reduce inflammation and<br />

stimulate blood circulation. Moringa powder and tablets are also said<br />

to have a beneficial effect on the cardiovascular system. Moreover,<br />

it is stated that the leaves have a positive effect on blood sugar and<br />

cholesterol levels.<br />

Unsaturated fatty acids: Behen oil<br />

In addition to Moringa powder, Moringa oil, also known as behen oil,<br />

is meeting increasing interest on the European markets. It is pressed<br />

from the ripe Moringa seeds. The cold-pressed organic virgin oil is<br />

mainly known as a massage oil and as an oil for skin and hair care. It<br />

is said to be effective against skin infections, allergies and hair loss.<br />

Moringa oil is also in demand as a cooking or salad oil. The sweetnutty<br />

tasting oil has a high content of omega-9 fatty acids, vitamin C<br />

and E.<br />

Photo © : Betigil, Ethiopia<br />

For more information, please visit<br />

www.importpromotiondesk.de/en/<br />

No. 3 November/December <strong>2023</strong><br />


Botanical extracts<br />

Photo © : shutterstock/seksan-wangjaisuk<br />

Botanical extracts:<br />

the natural solution to flavourists’ technical<br />

and organoleptic requirements<br />

Anne Manubens<br />

“80 % of consumers who say they are concerned about the composition<br />

of their food prioritise natural products free of preservatives and<br />

artificial colours.” 1 Far from anecdotal, this figure reflects not simply<br />

a trend but a reality in numerous markets: naturalness is a core<br />

consumer demand. And with ‘demand’ comes ‘response’ on the part<br />

of manufacturers, who must be able to rely on absolutely irreproachable<br />

raw materials and ingredients if they are to guarantee both the<br />

naturalness and functionality of food products. Such is Herbarom’s<br />

field of expertise. For almost 30 years, the company has been developing<br />

and offering natural botanical extracts enabling flavourists to<br />

respond to market demands.<br />

Botanical extracts: Herbarom expertise in creating value<br />

all along the chain<br />

Established at the heart of the Fragrant, Aromatic and Medicinal<br />

plants sector since 1994, Herbarom has forged unique know-how<br />

in both the sensorial and functional aspects<br />

of natural ingredients. Herbarom’s expertise<br />

draws on guaranteed sourcing and<br />

traceability through controlled and sometimes<br />

exclusive crop-growing contracts,<br />

thus ensuring the availability of fundamental<br />

botanical extracts such as essential<br />

oils and flavouring preparations in addition<br />

to the development of tailor-made extracts<br />

or ingredient blends meeting specific flavour<br />

profiles.<br />

An example of this advanced expertise is<br />

Petroselinum crispum (Mill.) Fuss parsley,<br />

one of Herbarom’s specialities par excellence.<br />

This know-how, acquired through years<br />

of experience in seed selection, extraction<br />

24 No. 3 November/December <strong>2023</strong>

Botanical extracts<br />

processes and blending, enables Herbarom<br />

to effectively respond to the aromatic profiles<br />

sought by its customers.<br />

Regulatory expertise: Herbarom’s<br />

added value for naturalness<br />

The growing demand for naturalness on the<br />

part of both manufacturers and consumers<br />

is therefore a reality which requires a keen<br />

sense of trend anticipation by the former<br />

in order to meet the exact demands of the<br />

latter. However, this sense of anticipation<br />

cannot be put to work effectively without<br />

guidance in regulatory compliance.<br />

For example, a flavour can only be described<br />

as ‘natural’ if the aromatic agents in its<br />

formulation are themselves natural (such<br />

as mint extract or essential oil of lemon,<br />

etc.). This guidance constitutes Herbarom’s<br />

added value. Trends, by nature volatile, can<br />

be applied to a product only in strict compliance<br />

with regulations, which change regularly.<br />

Regulatory expertise plays an inherent<br />

role in the composition of the end product,<br />

which in addition to the demand for naturalness,<br />

includes functional and emotional<br />

aspects.<br />

Botanical extracts:<br />

the source of functionality<br />

In developing a successful product, botani cal<br />

extracts offer a dual benefit by combining<br />

both functional and sensorial properties.<br />

Photo © : Pixabay<br />

Functionality is a fundamental trend in food and it is worth noting in<br />

this respect how the dividing line between food and nutraceuticals is<br />

blurring. Consumers are increasingly attracted to food products with<br />

a beneficial aspect, an encouraging sign of the growing awareness of<br />

the link between diet and good health. From a market perspective,<br />

the functional food and beverage market represented $259 billion in<br />

2020, and forecasts place this figure at $530 billion in 2028. 2<br />

In terms of naturalness, transparency, practicality and health benefits,<br />

functional beverages tick all the boxes with respect to consumer<br />

expectations, combining the response to a physiological need with<br />

taste pleasure and well-being. The most popular functional beverages<br />

among consumers are those targeting energy, immunity, detoxification<br />

and stress or sleep management.<br />

+<br />

Development of<br />

tailor-made solutions<br />




Essential oils<br />

Liquid extracts<br />

Aromatic substances<br />

Vegetable oils<br />


Botanical extracts<br />

This sensorial and organoleptic characterisation<br />

of ingredients is a Herbarom specificity,<br />

an essential skill in guiding customers’<br />

choice of ingredients and helping them to<br />

obtain their desired flavour.<br />

This natural quality of food products,<br />

combined with functionality and emotion,<br />

has thus become a key factor for consumers,<br />

who are increasingly attentive to both<br />

reduced ingredient lists, in addition to the<br />

correlation between the ways in which raw<br />

materials have been grown and used and<br />

the quality of the end product. 3 The steady<br />

growth of the natural ingredient market in the<br />

food sector is proof of this, and these ingredients<br />

are used in a wide range of applications,<br />

including culinary flavouring and<br />

plant-based beverages.<br />

Photo © : Shutterstock<br />

Herbarom boasts a unique chain of expertise<br />

in this market, from the selection of plant<br />

variety and cultivation with partner farmers,<br />

to extraction and technical or organoleptic<br />

qualification. This expertise is the result of<br />

almost 30 years of collaboration with the<br />

brands, laboratories and flavourists shaping<br />

the products of the future.<br />

For more than 15 years, the Herbarom Group has also been leading<br />

the development and tailoring of dietary supplements, with specific<br />

expertise in liquid forms. The company thus plays a strategic role in<br />

meeting the demand for functional food by developing plant extract<br />

solutions to be incorporated in the formulation of beverages.<br />

The emotional benefits of natural botanical extracts<br />

In addition to their functional properties, plant extracts are also<br />

emotional vectors. Their taste triggers olfactory memory, the ability we<br />

all have to recall a past event or moment associated with a specific<br />

smell. The olfactory receptors in our nose capture scent molecules<br />

and transmit signals to our brain, which we interpret as smell sensations.<br />

Added to this is the notion of taste and retronasal olfaction, and<br />

it is this complex combination of sensations which forms the flavour<br />

we can taste in food or drink.<br />

References<br />

1<br />

Agrotech survey, representation relative to the French<br />

population, Part 1: Food sensitivity and expectations -<br />

2022.<br />

2<br />

Fortune Business Insights, global functional food and<br />

beverage market, 2020<br />

3<br />

Le concept et la représentation visuelle de la naturalité<br />

des produits alimentaires pour le consommateur français<br />

[Concept and visual representation of food product naturalness<br />

for the French consumer], Annick Tamaro, Morgane<br />

Innocent, Patricia Mouen, HAL Science, 2022.<br />

For more information, please contact<br />

Anne Manubens,<br />

Group Marketing Director and Sales Director<br />

at Herbarom Laboratoire<br />

Phone +33(0)4 81160202<br />

www.herbarom-groupe.com<br />

26 No. 3 November/December <strong>2023</strong>

Natural plant extracts<br />

Photo © : shutterstock/Sergio Pazzano<br />

Why does Pycnogenol ® offer such<br />

a wide range of health benefits?<br />

Its mechanisms of action explained<br />

Dr. Franziska Weichmann<br />

Pycnogenol ® French maritime pine bark is<br />

dubbed the “gold standard ingredient”, “a<br />

phenomenon” and a “natural all-rounder” (1,<br />

2). Clinical studies have shown Pycnogenol ®<br />

to be beneficial for heart health, cognitive<br />

function and respiratory health, as well as<br />

for eye health, skincare, women’s health and<br />

several other body functions (3-10). But how<br />

can one ingredient alone have such a wide<br />

range of benefits across multiple applications?<br />

Let’s shed some light on the holistic<br />

nature and efficacy of Pycnogenol ® .<br />

Pycnogenol ® is much more than just<br />

an ingredient<br />

First and foremost, Pycnogenol ® stands<br />

apart from single compounds. Pycnogenol ®<br />

is a naturally programmed combination with<br />

constant proportions of procyanidins, bioflavonoids<br />

and organic acids, which offer amazing natural properties.<br />

Pycnogenol ® French maritime pine bark extract’s unique blend of<br />

active compounds cannot be found in any other plant extract. Each<br />

of its compounds provides a different way of acting in the body. Some<br />

of the larger molecules get further processed in the gut into metabolites.<br />

Remarkably, these metabolites are also absorbed into our bloodstream,<br />

contributing to Pycnogenol ® overall efficacy.<br />

Consequently, Pycnogenol ® offers a comprehensive array of active<br />

compounds, distinguishing it from single-component alternatives.<br />

The key properties of Pycnogenol ® on the body are its powerful antioxidant<br />

actions (3, 4, 11-16), its natural anti-inflammatory benefits<br />

(17-19), its effects on the skin and tissues (8, 18, 20, 21) and its<br />

support to blood circulation (3, 7, 22-33).<br />

Collectively, these mechanisms account for the extensive range of<br />

applications that Pycnogenol ® holds in the realms of health and<br />

beauty. Ongoing research will continue to unveil further insights<br />

and potentially discover additional applications for the effects of<br />

Pycnogenol ® .<br />

No. 3 November/December <strong>2023</strong><br />


Natural plant extracts<br />

15, 25, 26, 38-43). Interestingly, it was found that a metabolite of<br />

Pycnogenol ® can be taken up in endothelial cells and can thus exert<br />

its anti-inflammatory effects directly in the endothelium (24).<br />

Pycnogenol ® for the endothelium<br />

Numerous studies have consistently shown that Pycnogenol ® improves<br />

endothelial function, resulting in a positive impact on both blood circulation<br />

and microcirculation, firmly establishing its effectiveness.<br />

In patients with coronary artery disease, the effect of Pycnogenol ®<br />

on endothelial function was investigated by assessing “flow-mediated<br />

dilation” in the upper arm artery (3). For this method, the expansion<br />

of the artery in response to an increase in the shear stress associated<br />

with blood flow is measured. An 8-week randomized, placebocontrolled,<br />

crossover, double-blind study showed an improvement<br />

in flow-mediated dilation of 32 % in the Pycnogenol ® group, while it<br />

deteriorated slightly in the placebo patients.<br />

In another study, the flow-mediated dilation of patients with borderline<br />

high blood pressure, high blood lipid levels and increased blood sugar<br />

levels improved significantly after 8 and 12 weeks of Pycnogenol ®<br />

intake (27). These studies, among several others, confirm the positive<br />

effects of taking Pycnogenol ® on endothelial function in patients<br />

with cardiovascular diseases.<br />

Pycnogenol ® improves blood circulation<br />

Keeping the cardiovascular system healthy is key for maintaining good<br />

vitality, physical strength, mental health and for general well-being.<br />

Blood vessels bring oxygen and nutrients through arteries and the<br />

tiniest micro vessels all over our body, providing beneficial effects from<br />

head to toe. Pycnogenol ® exerts some of its beneficial effects as it optimizes<br />

blood flow by improving endothelial function. Blood flow regulation<br />

involves maintaining an appropriate distribution of blood throughout<br />

the body to meet the metabolic demands of tissues and organs.<br />

All blood vessels in the cardiovascular system are lined with the<br />

so-called endothelium. The endothelium is a single layer of cells<br />

lining the inner surface of blood vessels, including arteries and veins.<br />

This layer not only serves as a simple delimitation of the vessel wall<br />

but is also significantly involved in many physiological functions, like<br />

controlling blood pressure by vasoconstriction and-dilation, regulating<br />

the exchange of substances between blood and tissues, preventing<br />

blood clotting, and signaling during inflammation. Endothelial function<br />

and blood flow regulation are crucial for overall health.<br />

Pycnogenol ® improves microcirculation<br />

Healthy microcirculation is vital as it leads to a well-functioning supply<br />

of nutrients and oxygen to all parts of the body. In several previously<br />

published studies, Pycnogenol ® was shown to improve blood circulation<br />

in small blood vessels in the body, like the very fine micro vessels<br />

in the skin, fingertips and in the inner ear or the retinal capillaries in<br />

the eye (7, 28-31, 34-37).<br />

In a 3-month study on diabetic retinopathy, Pycnogenol ® supplementation<br />

improved the retinal blood flow by around 30 % compared to<br />

no change in the control patients (7). In another study with patients<br />

Many different studies have shown that Pycnogenol ® has a positive<br />

effect on blood circulation and microcirculation (7, 28-31, 34-37) by<br />

improving endothelial function (3, 22-27) and by lowering platelet<br />

aggregation without increasing bleeding time (32, 33). In addition,<br />

Pycnogenol ® has been shown to normalize blood pressure and to<br />

improve blood lipid profile as well as blood sugar values (12, 13,<br />

28 No. 3 November/December <strong>2023</strong>

Natural plant extracts<br />

suffering from coronary heart disease,<br />

microcirculation on the fingertip improved<br />

significantly in 54 % of the patients, taking<br />

Pycnogenol ® and in 33 % of the placebo<br />

patients after 4 weeks (31).<br />

inflammatory conditions like knee osteoarthritis (45, 46), endometriosis<br />

(47, 48) or allergic rhinitis (6, 49). Pycnogenol ® was shown to<br />

promote joint mobility and flexibility and naturally relieve pain.<br />

Pycnogenol ® helps break the<br />

cycle of inflammation and oxidative<br />

stress naturally<br />

The anti-inflammatory and antioxidant<br />

pro perties of Pycnogenol ® further contribute<br />

to the versatile nature of Pycnogenol ® on<br />

body health and beauty. Inflammation and<br />

oxidative stress. Inflammation and oxidative<br />

stress are closely linked processes in the<br />

body. Oxidative stress can trigger inflammation,<br />

and inflammation, in turn, can lead to<br />

more oxidative stress. (44). Initially, inflammation<br />

is a complex protective response of<br />

the body to harmful stimuli and is part of<br />

innate immunity. However, too much inflammation<br />

can lead to chronic inflammation -<br />

the basis of various diseases such as atherosclerosis,<br />

arthritis or allergies.<br />

Pycnogenol ® is a powerful antioxidant<br />

Pycnogenol ® has been investigated in various clinical studies<br />

and shown to possess potent antioxidant properties (3, 4, 11-16).<br />

Pycnogenol ® , when taken orally has been shown to both increase<br />

plasma antioxidant capacity, expressed as oxygen radical absorbance<br />

capacity (13), and decrease plasma oxidative stress measured<br />

as plasma free radicals (50). Pycnogenol ® has further been shown to<br />

protect lipids from peroxidation by free radicals in elderly people and<br />

people with coronary artery disease (3, 4). The protective effect of<br />

Pycnogenol ® on DNA oxidation was shown in a randomized, doubleblind,<br />

placebo-controlled study of children with ADHD, by measuring<br />

the level of oxidized purines (11).<br />

Pycnogenol ® controls inflammation<br />

In several studies, it was shown that<br />

Pycnogenol ® has inflammation reducing<br />

properties (17-19). Consumption of<br />

Pycnogenol ® was shown to significantly<br />

limit the activation of the pro-inflammatory<br />

«master switch» NF-kB by 15.5 % and<br />

matrix metalloproteinase 9 (MMP-9) release<br />

by 25 %. These are two important regulators<br />

in the inflammation process. This positive<br />

effect thus helps prevent the mobilization<br />

of proinflammatory molecules, which<br />

play a destructive role in arthritis. In another<br />

study, Pycnogenol ® significantly prevented<br />

the up-regulation of the pro-inflammatory<br />

enzymes 5-LOX and COX-2 after only five<br />

days of daily intake (17). (18). In addition,<br />

the consumption of a single dose of 300 mg<br />

Pycnogenol ® was found to naturally inhibit<br />

generation of COX-2 enzymes during inflammation<br />

in humans, thus providing a significant<br />

contribution for lowering pain (19).<br />

These beneficial effects of Pycnogenol ®<br />

were also observed in clinical studies with<br />

patients, suffering from different chronic<br />

Pycnogenol ® strengthens the extracellular matrix in skin,<br />

joints and other tissues<br />

The extracellular matrix consists of a complex mixture of proteins,<br />

glycoproteins, proteoglycans, and other molecules. It plays a vital role<br />

in various connective tissues, functioning as a supportive framework.<br />

It provides mechanical support to tissues, regulates cell behavior,<br />

and influences tissue development and repair. Collagen and elastin<br />

are crucial components of the skin’s extracellular matrix. Collagen<br />

provides structural support and firmness to the skin, while elastin<br />

ensures its elasticity. Hyaluronic acid contributes to skin hydration<br />

by retaining moisture. These molecules collectively promote youthful,

Natural plant extracts<br />

healthy skin and can help address issues related to aging and skin<br />

aging processes. In addition, collagen is a significant component<br />

of cartilage, which covers and protects the ends of bones in joints.<br />

It contributes to joint stability and flexibility. Hyaluronic acid is also<br />

found in joint fluid and lubricates and cushions the joints, allowing<br />

for smooth movement.<br />

Pycnogenol ® improves skin hydration and elasticity<br />

Pycnogenol ® was shown to increase skin elasticity and reduce skin<br />

fatigue by stimulation of the synthesis of new collagen and hyaluronic<br />

acid in the skin and inhibiting the activity of enzymes that break down<br />

collagen and elastin (8, 18, 20, 21). Pycnogenol ® further protects<br />

skin proteins against enzymatic degradation by selectively binding to<br />

elastin and collagen (21).<br />

Clinical investigations of Pycnogenol ® supplementation for 12 weeks<br />

with female volunteers, aged 55 to 68 years revealed increased hyaluronic<br />

acid synthase levels within the skin by 44 %, leading to improved<br />

skin hydration (20). Hyaluronic acid synthase is the natural source of<br />

water-binding hyaluronic acid in the dermis, which moisturizes the<br />

skin and keeps it taut and smooth.<br />

Consequently, an average skin-hydration increase by 21 % in the<br />

group of Pycnogenol ® supplementation was found, particularly in<br />

women presenting with dry skin prior to Pycnogenol ® intake. In this<br />

study, Pycnogenol ® was also shown to improve skin elasticity by<br />

25 % and decrease skin fatigue by 30 %. Interestingly, the results<br />

were paralleled by Pycnogenol ® ’s ability to generate skin’s connective<br />

tissue collagen in average by 40 %. In addition to stimulating the<br />

synthesis of new collagen, Pycnogenol ® metabolites can inhibit the<br />

release and activity of destructive enzymes (metalloproteinases 1,2<br />

and 9), which break down dermal tissue proteins, like collagen or<br />

elastin (18, 21). The reduced activity of these lytic enzymes saves the<br />

connective tissues from degradation, representing the basis for maintaining<br />

an elastic, smooth and youthful looking skin. The beneficial<br />

effects of Pycnogenol ® on the skin have been confirmed in several<br />

clinical studies.<br />

Pycnogenol ® has beneficial effects on joint function<br />

Pycnogenol ® has been shown to act beneficially in patients presenting<br />

with joint problems (45, 51-53). In a study with 33 patients suffering<br />

from severe osteoarthritis, a joint cartilage damaging condition, the<br />

level of matrix metalloproteinases (MMP) enzymes, that are responsible<br />

for destroying cartilage in joints was significantly downregulated<br />

in the fluid around the knee joints after taking Pycnogenol ®<br />

(46). These results confirm previous findings that regular intake of<br />

Pycnogenol ® leads to a potent decrease of pro-inflammatory markers<br />

like NF-κB and COX-enzymes and MMPs (17-19, 21).<br />

In most cases, joint pain is due to damage to the articular cartilage.<br />

Hyaluronic acid contributes to the shock-absorbing abilities of cartilage.<br />

As Pycnogenol ® significantly increased<br />

gene expression of hyaluronic acid synthase,<br />

this is helpful not only for skin but also for<br />

articular cartilage (20). Additionally, the abilities<br />

of Pycnogenol ® to increase the synthesis<br />

of collagen and to protect collagen from<br />

degradation are crucial for joint health as<br />

collagen is an important component of articular<br />

cartilage. These results are backed up<br />

by the finding of a strong increase of the<br />

concentration of Pycnogenol ® ’s metabolites<br />

in the synovial fluid, surrounding articular<br />

cartilage in the joints in osteoarthritis patients<br />

(46, 54). In this way, the active ingredients of<br />

Pycnogenol ® can act directly where they are<br />

needed. This comprehensively explains how<br />

Pycnogenol ® contributes to restoring health<br />

in damaged joints.<br />

Pycnogenol ® French pine bark extract is<br />

one of the most widely investigated natural<br />

supplements worldwide with convincing data<br />

for various fields of application, including<br />

heart health, skin care, cognitive function<br />

and allergy control. Pycnogenol ® is a standardized<br />

complex mixture of many molecules<br />

and has shown beneficial efficacy on blood<br />

circulation, strong anti-inflammatory and<br />

antioxidant effects and impressive action on<br />

the integrity of tissues.<br />

References<br />

1. Rohdewald P, Passwater RA. The Pycnogenol Phenomenon:<br />

The Most Unique & Versatile Health Supplement:<br />

Basic Health Publications, Inc.; 2015. 178 p.<br />

2. Horphag Research. Pycnogenol ® <strong>2023</strong> [Available from:<br />

https://www.pycnogenol.com/.<br />

3. Enseleit F, Sudano I, Periat D, Winnik S, Wolfrum M,<br />

Flammer AJ, et al. Effects of Pycnogenol on endothelial<br />

function in patients with stable coronary artery disease: a<br />

double-blind, randomized, placebo-controlled, cross-over<br />

study. Eur Heart J. 2012;33(13):1589-97.<br />

30 No. 3 November/December <strong>2023</strong>

Natural plant extracts<br />

4. Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey<br />

L, et al. An examination of the effects of the antioxidant<br />

Pycnogenol ® on cognitive performance, serum<br />

lipid profile, endocrino logical and oxidative stress<br />

biomarkers in an elderly population. J Psychopharmacol.<br />

2008;22(5):553-62.<br />

5. Weyns A-S, Verlaet AAJ, Breynaert A, Naessens T, Fransen<br />

E, Verhelst H, et al. Clini cal Investigation of French Maritime<br />

Pine Bark Extract on Attention-Deficit Hyperactivity<br />

Disorder as compared to Methylphenidate and Placebo:<br />

Part 1: Efficacy in a Randomised Trial. Journal of Functional<br />

<strong>Foods</strong>. 2022;97:105246.<br />

6. Wilson D, Evans M, Guthrie N, Sharma P, Baisley J,<br />

Schonlau F, et al. A randomized, double-blind, placebocontrolled<br />

exploratory study to evaluate the potential<br />

of pycnogenol for improving allergic rhinitis symptoms.<br />

Phytother Res. 2010;24(8):1115-9.<br />

7. Steigerwalt R, Belcaro G, Cesarone MR, Di Renzo A, Grossi<br />

MG, Ricci A, et al. Pycnogenol improves microcirculation,<br />

retinal edema, and visual acuity in early diabetic retinopathy.<br />

J Ocul Pharmacol Ther. 2009;25(6):537-40.<br />

8. Zhao H, Wu J, Wang N, Grether-Beck S, Krutmann J,<br />

Wei L. Oral Pycnogenol(R) Intake Benefits the Skin in<br />

Urban Chinese Outdoor Workers: A Randomized, Placebo-<br />

Controlled, Double-Blind, and Crossover Intervention<br />

Study. Skin Pharmacol Physiol. 2021:1-11.<br />

9. Maia H, Jr., Haddad C, Casoy J. The effect of pycnogenol<br />

on patients with dysmenorrhea using low-dose oral contraceptives.<br />

Int J Womens Health. 2014;6:1019-22.<br />

10. Kohama T, Negami M. Effect of low-dose French maritime<br />

pine bark extract on climacteric syndrome in 170 perimenopausal<br />

women: a randomized, double-blind, placebocontrolled<br />

trial. J Reprod Med. 2013;58(1-2):39-46.<br />

11. Chovanova Z, Muchova J, Sivonova M, Dvorakova M, Zitnanova I, Waczulikova I, et al.<br />

Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering<br />

from attention deficit/hyperactivity disorder. Free Radic Res. 2006;40(9):1003-10.<br />

12. Duracková Z, Trebatický B, Novotný V, Žitanová I, Breza J. Lipid metabolism and erectile<br />

function improvement by pycnogenol ® , extract from the bark of pinus pinaster in patients<br />

suffering from erectile dysfunction-a pilot study. Nutrition Research. 2003;23(9):1189-98.<br />

13. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. Supplementation<br />

with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and<br />

alters plasma lipoprotein profile. Lipids. 2002;37(10):931-4.<br />

14. Kolacek M, Muchova J, Dvorakova M, Paduchova Z, Zitnanova I, Cierna I, et al. Effect<br />

of natural polyphenols (Pycnogenol) on oxidative stress markers in children suffering from<br />

Crohn's disease--a pilot study. Free Radic Res. 2013;47(8):624-34.<br />

15. Yang HM, Liao MF, Zhu SY, Liao MN, Rohdewald P. A randomised, double-blind, placebocontrolled<br />

trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal<br />

women. Acta Obstet Gynecol Scand. 2007;86(8):978-85.<br />

16. Errichi S, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, et al. Supplementation<br />

with Pycnogenol ® improves signs and symptoms of menopausal transition. Panminerva<br />

Med. 2011;53(3):65-70.<br />

17. Canali R, Comitato R, Schonlau F, Virgili F. The anti-inflammatory pharmacology of<br />

Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. Int Immunopharmacol.<br />

2009;9(10):1145-9.<br />

18. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Duracková Z, et al. Inhibition<br />

of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after<br />

ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1.<br />

19. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, et al. Inhibition<br />

of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French<br />

maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2005;60(1):5-9.<br />

20. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, et al. Pycnogenol(R)<br />

effects on skin elasticity and hydration coincide with increased gene expressions of collagen<br />

type I and hyaluronic acid synthase in women. Skin Pharmacol Physiol. 2012;25(2):86-92.<br />

21. Grimm T, Schäfer A, Högger P. Antioxidant activity and inhibition of matrix metalloproteinases<br />

by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med.<br />

2004;36(6):811-22.<br />

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Natural plant extracts<br />

22. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of<br />

Pycnogenol. J Cardiovasc Pharmacol. 1998;32(4):509-15.<br />

23. Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D, Soga J, et al. Pycnogenol,<br />

French maritime pine bark extract, augments endothelium-dependent vasodilation in<br />

humans. Hypertens Res. 2007;30(9):775-80.<br />

24. Uhlenhut K, Högger P. Facilitated cellular uptake and suppression of inducible nitric<br />

oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol). Free Radic Biol<br />

Med. 2012;53(2):305-13.<br />

25. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P. Pycnogenol, French maritime<br />

pine bark extract, improves endothelial function of hypertensive patients. Life Sci.<br />

2004;74(7):855-62.<br />

26. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in<br />

subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008;28(5):315-20.<br />

27. Hu S BG, Cornelli U, et al Effects of Pycnogenol ® on endothelial dysfunction in borderline<br />

hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study. Int<br />

Angiol 2015;34(1):43-52.<br />

28. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, et al. Diabetic<br />

ulcers: microcirculatory improvement and faster healing with pycnogenol. Clin Appl Thromb<br />

Hemost. 2006;12(3):318-23.<br />

29. Belcaro G. LR, Dugall M., Ippolito E., Saggino A. Venous ulcers: Microcirculatory improvement<br />

and faster healing with local use of Pycnogenol ® . Angiology. 2005;56(6):699-705.<br />

30. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, et al.<br />

Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study.<br />

Angiology. 2006;57(4):431-6.<br />

31. Wang S, Tan D, Zhao Y, Gao G, Gao X, Hu L. The effect of Pycnogenol ® on the microcirculation,<br />

platelet function and ischaemic myocardium in patients with coronary artery<br />

diseases. European Bulletin of Drug Research. 1999;7(2):19-25.<br />

32. Araghi-Niknam M, Hosseini, S, Larson, D, Rohdewald, P and watson, RR. Pine bark<br />

extract reduces platelet aggregation. Integrative Medicine. 1999;2(2/3).<br />

33. Pütter M GK, Würthwein G, Araghi-Niknam M, Watson RR, Hosseini S, Rohdewald P. .<br />

Inhibition of smoking-induced platelet aggregation by Aspirin and Pycnogenol. Thrombosis<br />

Research 1999;55:155–61.<br />

34. Cai C, Zeng B, Lin L, Zheng M, Burki C, Grether-Beck S, et al. An oral French maritime<br />

pine bark extract improves hair density in menopausal women: A randomized, placebocontrolled,<br />

double blind intervention study. Health Science Reports. <strong>2023</strong>;6(1).<br />

35. Cesarone MR, Belcaro G, Agus GB, Ippolito E, Dugall M, Hosoi M, et al. Chronic<br />

venous insufficiency and venous microangiopathy: management with compression and<br />

Pycnogenol(R). Minerva Cardioangiol. 2019;67(4):280-7.<br />

36. Luzzi R, Belcaro G, Hu S, Dugall M, Hosoi M, Cacchio M, et al. Improvement in symptoms<br />

and cochlear flow with Pycnogenol in patients with Meniere’s disease and tinnitus.<br />

Minerva Med 2014;105:245-54.<br />

37. Grossi MG, Belcaro G, Cesarone MR, Duggall M, Hosoi M. Improvement in cochlear<br />

flow with Pycnogenol ® in patients with tinnitus: a pilot evaluation. Panminerva Med.<br />

2010;52(2):63-7.<br />

38. Hosseini S LJ, Sepulveda RT, Rohdewald P, Watson RR. A randomized, double-blind,<br />

placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol<br />

in modifying blood pressure in mildly hypertensive patients. Nutr Res. 2001;21(9):1251-60.<br />

39. Stuard SBG, Cesarone, M.R., Ricci, A., Dugall, M., Cornelli, U., Gizzi, G. Pellegrini L,<br />

Rohdewald, P.J. Kidney function in metabolic syndrome may be improved with Pycnogenol.<br />

Panminerva Med. 2010;52(2):27-32.<br />

40. Schäfer A, Högger P. Oligomeric procyanidins of French maritime pine bark<br />

extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res Clin Pract.<br />

2007;77(1):41-6.<br />

41. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency.<br />

Phytother Res. 2002;16 Suppl 1:S1-5.<br />

42. Trebaticky B, Muchova J, Ziaran S, Bujdak P, Breza J, Durackova Z. Natural polyphenols<br />

improve erectile function and lipid profile in patients suffering from erectile dysfunction.<br />

Bratisl Med J. 2019;120(12):941 – 4.<br />

43. Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, et al. Pycnogenol(R)<br />

supplementation improves health risk factors in subjects with metabolic syndrome. Phytother<br />

Res. 2013;27(10):1572-8.<br />

44. Zuo L, Prather EL, Stetskiv M, Garrison DE, Meade<br />

JR, Peace TI, et al. Inflammaging and Oxidative Stress in<br />

Human Diseases: From Molecular Mechanisms to Novel<br />

Treatments. International Journal of Molecular Sciences.<br />

2019;20(18):4472.<br />

45. Cisar P, Jany R, Waczulikova I, Sumegova K, Muchova<br />

J, Vojtassak J, et al. Effect of pine bark extract (Pycnogenol)<br />

on symptoms of knee osteoarthritis. Phytother Res.<br />

2008;22(8):1087-92.<br />

46. Jessberger S, Högger P, Genest F, Salter DM, Seefried<br />

L. Cellular pharmacodynamic effects of Pycnogenol(R) in<br />

patients with severe osteoarthritis: a randomized controlled<br />

pilot study. BMC Complement Altern Med. 2017;17(1):537.<br />

47. Kohama T, Herai, K., Inoue, M Effect of French Maritime<br />

Pine Bark Extract on endometriosis as compared with<br />

leuprorelin acetate. J Reprod Med. 2007;52(8):703-8.<br />

48. Maia H, Jr., Haddad C, Casoy J. Combining oral contraceptives<br />

with a natural nuclear factor-kappa B inhibitor for<br />

the treatment of endometriosis-related pain. Int J Womens<br />

Health. 2013;6:35-9.<br />

49. Belcaro G LR, Cesinaro di Rocco P, Cesarone MR,<br />

Dugall M, Feragalli B, Errichi BM, Ippolito E, Grossi MG,<br />

Hosoi M, Errichi S, Cornelli U, Ledda A, Gizzi G. Pycnogenol<br />

improvements in asthma management. Panminerva Med.<br />

2011;53(3):57-64.<br />

50. Belcaro H, Cesarone, Dugall. A controlled study shows<br />

daily intake of 50 mg of French Pine Bark Extract (Pycnogenol<br />

® ) lowers plasma reactive oxygen metabolites in<br />

healthy smokers. Minerva medica. 2013;104(4):439-46.<br />

51. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi<br />

BM, Vinciguerra G, et al. Variations in C-reactive protein,<br />

plasma free radicals and fibrinogen values in patients<br />

with osteoarthritis treated with Pycnogenol. Redox Rep.<br />

2008;13(6):271-6.<br />

52. Farid R, Mirfeizi Z, Mirheidari M, Rezaieyazdi Z,<br />

Mansouri H, Esmaelli H, et al. Pycnogenol supplementation<br />

reduces pain and stiffness and improves physical function<br />

in adults with knee osteoarthritis. Nutrition Research.<br />

2007;27(11):692-7.<br />

53. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM,<br />

Vinciguerra G, et al. Treatment of osteoarthritis with Pycnogenol.<br />

The SVOS (San Valentino Osteo-arthrosis Study).<br />

Evaluation of signs, symptoms, physical performance and<br />

vascular aspects. Phytother Res. 2008;22(4):518-23.<br />

54. Mülek M, Seefried L, Genest F, Högger P. Distribution of<br />

Constituents and Metabolites of Maritime Pine Bark Extract<br />

(Pycnogenol((R))) into Serum, Blood Cells, and Synovial<br />

Fluid of Patients with Severe Osteoarthritis: A Randomized<br />

Controlled Trial. Nutrients. 2017;9(5).<br />

For more information, please contact<br />

Dr. Franziska Weichmann,<br />

Manager of Scientific Communications and<br />

Product Development at<br />

Horphag Research<br />

www.pycnogenol.com<br />

32 No. 3 November/December <strong>2023</strong>

Energy drinks<br />

Photo © : Stocksy_txp142854ebI5o300_OriginalDelivery_837852k<br />

“Caffeine alone is not enough”: Reinventing<br />

the ‘energy drink’ for a modern lens<br />

Fredrik Hjelmqvist<br />

Modern life is demanding as many know.<br />

Work, education, childcare, commuting, exercise<br />

and even – occasionally – just having fun,<br />

for consumers today it can feel like they need<br />

an endless reservoir of energy, just to make<br />

it through the day. It’s unsurprising then,<br />

that energy drink sales are on the rise. The<br />

global energy drinks market is projected to<br />

grow at a CAGR of 8 % over the next decade,<br />

reaching a value of $108 billion by 2031. 1<br />

Energy boosting beverages are as popular as<br />

ever, but is caffeine content alone enough to<br />

excite consumers? The holistic wellness trend<br />

sweeping the food and beverage sector has<br />

made an indelible impact on shoppers’ priorities,<br />

blurring the lines between health, indulgence<br />

and functional nutrition. The consequence<br />

of this attitude shift for the beverage<br />

segment is that shoppers don’t just want<br />

‘energy’ drinks, but solutions to give them<br />

an all-round boost with cognitive and mood<br />

support, as well as improved alertness and<br />

endurance.<br />

Read on as we discuss the latest nutraceutical trends and ingredients<br />

designed to promote a healthy mood and energize the body,<br />

and how producers can level up their energy drink offering for the<br />

modern market.<br />

A new view on ‘energy’<br />

Despite their enduring popularity, energy drinks have had somewhat<br />

of a bad reputation in the popular consciousness – thought of as<br />

‘quick fixes’ full of sugar, excessive amounts of caffeine and artificial<br />

ingredients. Even among university-aged young adults – the demographic<br />

group most likely to consume energy drinks – the potential<br />

side effects of these beverages are well known. 2 According to one<br />

study, after consuming a traditional energy drink, 42 % of students<br />

reported experiencing an increased heartbeat, 36 % cited jitteriness<br />

and 29 % spoke of anxiety or irritability. 3 Results like this have played<br />

a major role in shifting attitudes towards energy drinks in recent<br />

years, and the subsequent rise of a more natural, healthy approach<br />

to energy enhancement.<br />

Perhaps the biggest change here relates to sugar content. Excessively<br />

sweet foods and beverages are an increasing concern for<br />

consumers, and regulators alike, with the European Soft Drinks asso-<br />

No. 3 November/December <strong>2023</strong><br />


Energy drinks<br />

It’s been said a thousand times; taste is king. No matter how revolutionary<br />

a beverage’s proclaimed benefits are, if it cannot deliver<br />

a delicious flavour and attractive sensory experience, consumers<br />

simply won’t come back for more. The challenge for today’s energy<br />

drink formulators is balancing taste against consumer expectations<br />

for a natural and low-sugar positioning. Here we’ve seen plantbased<br />

prebiotic fibres and, more recently,<br />

fermented sweetening options come to the<br />

fore as a natural solution to creating a great<br />

taste, without excess added sugar.<br />

Photo © : GettyImages-1129493647<br />

ciation, UNESDA, extending its 2025 sugar reduction targets by a<br />

further 10 % 4 , mirroring similar initiatives from food standards agencies<br />

around the world. In tandem with increased regulatory scrutiny,<br />

consumers are driving progress through their purchasing decisions.<br />

Close to a quarter of recent energy drink launches featured a ‘sugar<br />

free’ positioning 5 , while 15 % combined the claims ‘no added sugar’<br />

and ‘natural energy drink’. 6 This second point brings up the equally<br />

crucial factor of ‘naturalness’. Research from dsm-firmenich found<br />

that around 80 % of beverage consumers wanted to know whether<br />

a product contained natural or artificial colorants, with the former<br />

achieving a significantly higher purchase intent. 7 When it comes to<br />

the look, feel and taste of energy drinks designed for a contemporary<br />

audience, brands clearly need to focus on blending naturalness with<br />

that all important low-sugar positioning.<br />

Attitudes are also in flux regarding the functional side of energy<br />

drinks. Consumers still want their caffeine fix, but a simple, shortterm<br />

energy boost is no longer enough for some. Digestive health<br />

and immune support, for example, were cited as the most appealing<br />

functional beverage benefits by more than 70 % of consumers in a<br />

recent Global Data survey 8 , while Mintel found that almost a third of<br />

energy drink consumers would be motivated to buy a product proven<br />

to promote brain health. 9 Vitamin and mineral content too is a central<br />

purchase driver in the energy drink segment, both in terms of classic<br />

inclusions like fatigue-fighting B vitamins, and familiar favourites like<br />

vitamin C. The energy drink market is entering a whole new era of<br />

dynamism, creating exciting opportunities for beverage manufacturers.<br />

What brands need now is the right, high-quality ingredients<br />

to address evolving consumer priorities around taste, colour, sugar<br />

content and functionality.<br />

The fundamentals: Taste, texture and colour<br />

Nature is similarly a key inspiration in<br />

the realm of colorants. Ingredients like<br />

β-Carotene – a family of carotenoid pigments<br />

– for instance, have been used to great<br />

success to bring vibrant red, orange and<br />

yellow hues to beverages, the natural way.<br />

There are even plant-derived solutions for<br />

improving product texture – an aspect too<br />

often overlooked in energy drink formulation.<br />

Hydrocolloids such as pectin are an invaluable<br />

tool for enhancing the appearance<br />

and mouthfeel of ready-to-drink beverages,<br />

imbuing drinks with a smooth texture that<br />

lets star flavours shine and ensures all active<br />

ingredients are thoroughly suspended.<br />

The main event: Energy boosting<br />

ingredients<br />

The clue is in the name – ‘energy’ drinks,<br />

even naturally positioned, multifunctional<br />

ones, still need to provide consumers with a<br />

much-needed boost. Caffeine and, to a lesser<br />

extent, B vitamins remain the front runners<br />

in this space, but producers have begun<br />

exploring the potential of alternative energy<br />

enhancers. Proteins (including collagen<br />

peptides) and amino-acids have been shown<br />

to contribute to increased satiety 10 , as well as<br />

sports recovery benefits like reduced muscle<br />

soreness 11 , while vitamin-like substances<br />

like Coenzyme Q-10 help support a healthy<br />

cardiovascular system. 12<br />

Building out the nutrition profile:<br />

Additional functional ingredients<br />

As mentioned above, consumers are looking<br />

for more than ‘empty energy’ from their<br />

beverage choices. From CBD to yerba mate<br />

extract, adaptogens to vitamins, the wide<br />

array of functional ingredients we’ve seen<br />

added to energy drinks has gone a long way<br />

towards shifting the segment’s ‘unhealthy’<br />

reputation. The crucial point to remember<br />

here for drinks manufacturers is not just<br />

what ingredients to include, but how they are<br />

34 No. 3 November/December <strong>2023</strong>

Energy drinks<br />

incorporated. Not all trending ingredients<br />

are easy to blend into a beverage format,<br />

requiring careful management of sweetening<br />

solutions, texturizers, energy-boosting<br />

inclusions and functional extras to create the<br />

ideal end product. It’s here where the help of<br />

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Single supplier, multiple benefits<br />

To stand out in the increasingly competitive<br />

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position in the energy drink market. At dsmfirmenich,<br />

we strive to be this ‘one-stopshop’<br />

for our customers, helping them work<br />

smarter at speed to create the next energy<br />

drink sensation.<br />

References<br />

1<br />

Global Opportunity Analysis and Industry Forecast, 2020-<br />

2031, Allied Market Research<br />

2<br />

Ghozayel M, Ghaddar A, Farhat G, Nasreddine L, Kara J,<br />

Jomaa L. Energy drinks consumption and perceptions<br />

among University Students in Beirut, Lebanon: A mixed<br />

methods approach. PLoS One. 2020 Apr 30;15(4):e0232199.<br />

doi: 10.1371/journal.pone.0232199. PMID: 32353017;<br />

PMCID: PMC7192412.<br />

3<br />

Ibid, Ghozayel et al, Energy drinks consumption and<br />

perceptions among University Students in Beirut, Lebanon<br />

4<br />

UNESDA, Soft drinks industry’s sugar reduction commitments<br />

across Europe, https://www.unesda.eu/sugarand-calorie-reduction/#:~:text=UNESDA%20has%20<br />

committed%20to%20reduce,milk%20based%20and%20<br />

hot%20beverages<br />

5<br />

Mintel GNDP database, accessed March 2022<br />

6<br />

Future Market Insights, Soft drinks industry’s sugar reduction<br />

commitments across Europe, September 2022, https://<br />

www.futuremarketinsights.com/reports/energy-drinksmarket?utm_source=adwords&utm_medium=ppc&utm_<br />

source=adwords&utm_medium=ppc&id=5&gclid=CjwKCAjw38SoBhB6EiwA8EQVLtCoM9MUCAY62vk0dM<br />

8OqDcBzECHy7n9Ks5SeLddNCs0fZgGigbr5BoCKDwQAvD_<br />

BwE<br />

7<br />

Global coloration study, dsm-firmenich 2021<br />

8<br />

GlobalData, 2021 Q2 global consumer survey<br />

9<br />

A year of innovation in sports and energy drinks, Mintel 2020<br />

10<br />

Moon J, Koh G. Clinical Evidence and Mechanisms of High-<br />

Protein Diet-Induced Weight Loss. J Obes Metab Syndr.<br />

2020 Sep 30;29(3):166-173. doi: 10.7570/jomes20028.<br />

PMID: 32699189; PMCID: PMC7539343<br />

11<br />

Kuwaba K, Kusubata M, Taga Y, Igarashi H, Nakazato<br />

K, Mizuno K. Dietary collagen peptides alleviate exercise-induced<br />

muscle soreness in healthy middle-aged<br />

males: a randomized double-blinded crossover clini cal<br />

trial. J Int Soc Sports Nutr. <strong>2023</strong> Dec;20(1):2206392. doi:<br />

10.1080/15502783.<strong>2023</strong>.2206392. PMID: 37133292;<br />

PMCID: PMC10158542.<br />

12<br />

Saini R. Coenzyme Q10: The essential nutrient. J Pharm<br />

Bioallied Sci. 2011 Jul;3(3):466-7. doi: 10.4103/0975-<br />

7406.84471. PMID: 21966175; PMCID: PMC3178961.<br />

Faster.<br />

Farther.<br />

Longer.<br />

For more information, please visit<br />

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a-total-solution-for-energy-drinks--nowthat-s-worth-getting-energized-about.<br />

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Fredrik Hjelmqvist,<br />

Senior Vice President Beverages & More,<br />

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Sweetening alternatives<br />

Photo © : AdobeStock_MUS_GRAPHIC<br />

Made from dates in Tunisia<br />

Date derivatives as a<br />

special sweetening alternative<br />

Who doesn't know – especially at Christmas time – the<br />

wonderful taste of dates?! This aromatic sweetness and a<br />

hint of oriental delight. Very popular are Deglet Nour dates.<br />

What is special about this date variety is its small fruit<br />

and firm flesh. Almost one third of the world’s Deglet Nour<br />

production comes from Tunisia. Overall, Tunisia is one of the<br />

largest date exporters in the world. More than 200 different<br />

date varieties grow in Tunisia, the most widespread being the<br />

Deglet Nour variety. Although the focus of Tunisian agriculture<br />

is on the export of fresh dates, the offer of processed<br />

dates is also growing. Dates can be processed into a variety<br />

of pro ducts: Syrup, powder, paste, juice from the fruits. The<br />

kernels can also be used to produce oil and coffee substitutes.<br />

The sugar alternatives such as date paste, powder and<br />

syrup impress with their taste and nutritional profile. The<br />

PAMPAT Tunisia project, implemented by the UN Industrial<br />

Develop ment Organization (UNIDO) and financed by the Swiss<br />

State Secretariat for Economic Affairs (SECO), supports the<br />

marketing of date products. At this year’s Anuga in Cologne,<br />

PAMPAT Tunisia organised a cooking show together with the<br />

Tunisian export promotion agency CEPEX to demonstrate the<br />

taste and uses of processed dates.<br />

Full of nutrients<br />

2 nd choice dates that cannot be sold as a<br />

fresh product are processed into natural<br />

sweeteners. Date syrup, for example, also<br />

contains minerals and vitamins from the date<br />

fruit compared to ordinary sugar (sucrose).<br />

Deglet Nour dates are rich in potassium,<br />

but also contain calcium, magnesium and B<br />

vitamins. Another advantage: date syrup has<br />

significantly fewer calories than sucrose. The<br />

date products consist mainly of fructose and<br />

retain the typical date flavour.<br />

“We like to use alternative sweeteners in our<br />

recipes,” says star chef Julia Komp from<br />

Cologne (“Sahila”) at Anuga. “Especially if<br />

they contain valuable nutritional values in<br />

addition to the sweetness. Date syrup is also<br />

vegan and thus a good honey alternative. We<br />

appreciate date sweetness, also because it<br />

gives dishes an oriental touch.”<br />

36 No. 3 November/December <strong>2023</strong>

Date syrup, paste and powder<br />

Date syrup is a good alternative to honey, maple syrup, agave syrup,<br />

sugar beet syrup etc. Date syrup tastes less sweet than sugar and<br />

is good for sweetening mueslis and desserts, for example. In the<br />

production process, dates are cooked and the date juice is extracted.<br />

The juice is then boiled down to syrup.<br />

The main product in Tunisia with a production volume of around<br />

10,000 tons is date paste. It is rich in dietary fibre and you can use<br />

it in baking. Date powder is also used as substitute for refined sugar,<br />

especially in baking. Date powder is made from 100 percent dates by<br />

cleaning, pitting, drying at 70° C, grinding and final sieving the dates.<br />

Healthy and vegan sweetener<br />

Date products are still little known, but there is great potential<br />

because alternative natural and healthy sweeteners are in demand.<br />

In addition, unlike honey, date products are also suitable for vegan<br />

diets. “Almost one in three dates is not suitable for marketing as<br />

fresh dates”, explains Nuria Ackermann, Chief Technical Advisor<br />

of the PAMPAT Project (UNIDO). “And this proportion of 2 nd choice<br />

dates will increase as global warming will reduce date quality. But<br />

with processed dates and the wide range of products, Tunisia has<br />

an opportunity to develop a new segment and add value. Through<br />

processing, 2 nd choice dates can increase in value by five times.”<br />

NFOBOX<br />

About PAMPAT Tunisia<br />

PAMPAT (Project for Market Access of Typical Agrofood<br />

Products) promotes the marketing of regionally produced<br />

Tunisian food products both in Tunisia itself and on international<br />

markets. The approach includes the development of<br />

value chains, the promotion of origin-based quality labels and<br />

the promotion of products, including at international trade fairs<br />

such as Anuga.<br />

PAMPAT is a project of the United Nations Industrial<br />

Development Organization (UNIDO) and is financed by the<br />

Swiss State Secretariat for Economic Affairs (SECO). It is being<br />

implemented in close cooperation with the Tunisian Ministry<br />

of Economy, Finance and Investment Promotion, the Ministry<br />

of Industry, Energy and Mines and the Ministry of Agriculture,<br />

Water Resources and Fisheries.<br />

For more information, please visit<br />

www.pampat.tn/en/<br />

Create excitement with<br />

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No. 3 November/December <strong>2023</strong><br />


Sweetening alternatives<br />

When it comes to baked goods it is crucial that alternative sweetening solutions provide a similar bulk than sugar.<br />

Photo © : shutterstock/4 PM production<br />

Ticking the boxes for sweetness and<br />

improved nutritional properties<br />

Klaudia Volmer<br />

Products using alternative sugars or sweeteners, and their<br />

effects on health, are under constant re-evaluation. Recent<br />

criticism of artificial sweeteners brought new attention to the<br />

topic, and calls for a closer look at existing solutions. Here,<br />

BENEO’s low-glycaemic ingredients from sugar beet offer<br />

indulgence while aligning with a healthy diet.<br />

Alternatives to traditional sugar is a topic that has recently hit the<br />

headlines following WHO’s publication of new guidelines on nonsugar<br />

sweeteners. The organisation advises against the use of noncaloric<br />

sweeteners for weight management, seeing them as a false<br />

friend when it comes to losing weight. Moreover, WHO says there<br />

may be other potential harmful effects from long-term use, such<br />

as an increased risk of type 2 diabetes, cardiovascular diseases,<br />

and mortality in adults. 1 The widespread notion that high-intensity<br />

sweeteners do not influence the human body has been challenged<br />

before. Data from human and animal studies indicate that nonnutritive<br />

sweeteners seem to impair glucose tolerance which might<br />

be mediated by changes in the gut microbiome.<br />

Though further research is needed<br />

for a better understanding, these results<br />

give reason to be cautious about the use of<br />

certain sweeteners. Luckily, the takeaway<br />

message is not to abandon anything sweet<br />

from the recipe or opt for industrial sugar,<br />

but take an informed decision on sweetening<br />

ingredients.<br />

Low-glycaemic carbohydrates<br />

gain traction<br />

Industrial sugar, but also natural sugars such<br />

as honey, for example, lead to a sharp rise<br />

of blood sugar levels quickly followed by a<br />

sudden fall. This so-called “boost and crash<br />

effect” usually causes strong cravings, which<br />

38 No. 3 November/December <strong>2023</strong>

Sweetening alternatives<br />

can lead to increased calorie intake. In the<br />

long run, these extreme changes in blood<br />

sugar levels, and thus also in insulin levels,<br />

can put a strain on the human body and also<br />

increase the risk of insulin resistance.<br />

Benefits for seniors and athletes alike<br />

The mentioned health benefits that Palatinose offers are interesting<br />

for various consumer groups. The potential for blood glucose<br />

management is, for example, particularly evident for the silver generation.<br />

As we age, biological processes slow down and metabolic<br />

responses become less effective. As a consequence, insulin resistance<br />

and impaired glucose tolerance is more likely.<br />

Moreover, as people get older, they tend to gain weight, which can<br />

lead to further health problems. Overweight or obese people show<br />

an increased risk for conditions such as higher blood pressure,<br />

cholesterol, triglycerides and thrombosis. Impaired glucose tolerance<br />

increases with age, as does the development of Diabetes mellitus. 2<br />

These can all increase the chances of non-communicable diseases<br />

such as cardiovascular disease, hypertension or type-2 diabetes.<br />

Fig. 1: Palatinose TM has a more moderate effect<br />

on blood sugar levels than conventional sugar.<br />

Photo © : BENEO<br />

This is where low-glycaemic carbohydrates<br />

act differently. They release their glucose<br />

more slowly and help to keep blood sugar<br />

levels more balanced. Beet sugar-derived<br />

Palatinose belongs to this group of lowglycaemic<br />

carbs. It provides energy over<br />

longer periods of time compared to conventional<br />

sugar. As the only fully available and<br />

slowly digestible carbohydrate with a low<br />

glycaemic index of 32, it delivers the same<br />

amount of energy to the body as sucrose<br />

(4 kcal/g). In comparison, conventional<br />

sugar is metabolised quickly, and blood<br />

glucose levels rise sharply before dropping<br />

to the basal level about one hour after intake.<br />

Palatinose, however, takes up to two hours<br />

to become fully digested and causes no boost<br />

and crash effect. This can be explained by<br />

the different structure of Palatinose and<br />

sucrose: Although, they resemble each<br />

other in their molecular structure, the fructose-glucose<br />

connection of Palatinose<br />

is more stable than that of sucrose. The<br />

enzymes in the small intestine take about<br />

four to five times as long to fully break down<br />

Palatinose. Thus, the contained glucose<br />

is gradually released into the bloodstream,<br />

keeping insulin secretion low, which, in turn,<br />

promotes fat burning.<br />

In order to counteract such “side effects” of ageing and avoid or<br />

reduce weight gain in seniors – and also in younger generations –<br />

a low release of the hormone insulin is key. Therefore, successful<br />

weight management must take blood sugar levels into account.<br />

In practice, this means choosing foods and beverages with only<br />

moderate glycaemic effects.<br />

The higher fat-burning rate combined with a slower, more balanced<br />

glucose supply, makes the low-glycaemic carb Palatinose appealing<br />

in the field of sports nutrition too. As endurance athletes aim for higher<br />

fat-burning rates as a means to improve endurance and conserve<br />

limited glycogen stores, Palatinose can be a true asset.<br />

Fig. 2: Naturalness meets functionality: BENEO’s Palatinose TM and Isomalt<br />

are derived from sugar beet. Photo © : BENEO<br />

No. 3 November/December <strong>2023</strong>

Sweetening alternatives<br />


Chicory root fibres:<br />

Inulin and oligofructose are further low-glycaemic ingredients.<br />

As prebiotic fibres, they come with a special focus on digestive<br />

health. While their main purpose is to support the gut, they also<br />

show a beneficial side effect by helping to replace sugar in end<br />

products. Inulin is a non-digestible fibre that occurs naturally<br />

in many fruits and vegetables, with chicory root as an abundant<br />

source. As it is not broken down in the small intestine,<br />

it reaches the large intestine intact and serves as “food” for<br />

the beneficial intestinal bacteria. The subsequent fermenting<br />

process in the gut produces short-chain fatty acids which have<br />

a positive effect on the intestinal tract, helping to maintain the<br />

intestinal mucosa while inhibiting the presence of undesirable<br />

bacteria. An EU health claim confirms that inulin promotes<br />

digestive health.<br />

BENEO’s chicory root fibres Orafti ® Inulin and Oligofructose<br />

have texturising properties, a mild taste, well-balanced,<br />

round flavour and deliver half as many calories as sugar. Due<br />

to their good solubility, the prebiotic fibres are suitable for a<br />

range of solid and liquid applications. Since they do not have an<br />

e-number, they allow for clean label recipes too.<br />

By raising the fibre content, while reducing sugar, prebiotic<br />

fibres make products healthier. Therefore, they support nutritional<br />

claims as well as a better Nutri-Score rating. In beverages,<br />

inulin and oligofructose benefit from the latest Nutri-Score<br />

updates. In April <strong>2023</strong>, the classification for drinks underwent<br />

a few changes in order to be more informative for consumers.<br />

These changes will also be valid for milk, milk-based and plantbased<br />

drinks that will be included in the drinks category. One<br />

of the major adaptations concerns the sugar content, which will<br />

have a greater impact on the score once the changes are implemented<br />

in 2024, with a transition period of two years. Here,<br />

reformulation of drinks with prebiotic fibres from chicory root<br />

will clearly be advantageous.<br />

Moreover, the advantages of this alternative sugar extend beyond<br />

actual physi cal activity, as it also supports recovery and replenishes<br />

glycogen levels. To provide their body with sufficient energy,<br />

many athletes include a bedtime drink in their diet, especially after<br />

demanding hours of training or competition. Even at rest, their body<br />

tends to burn more calories compared to the average individual. This<br />

need for energy can interfere with the athlete’s recovery at night-time,<br />

too, when there is no food intake over many hours. Palatinose and<br />

its balanced glucose supply help to bridge this gap.<br />

Furthermore, there is scientific evidence that Palatinose can<br />

help maintain thermoregulation during exercise 3 – an interesting<br />

benefit considering that athletes have to cope with ever-increasing<br />

Fig. 3: Palatinose is suitable for a wide range of food and drink<br />

applications, including sports beverages. Photo © : shutterstock/Ukrolenochka<br />

temperatures in summertime. Tests with an<br />

isomaltulose-electrolyte-drink during exercise<br />

demonstrated that it was just as good as<br />

an electrolyte drink with sucrose in regulating<br />

the body temperature and even showed a<br />

beneficial effect on hydration as more fluid<br />

was stored in the body and less urine was<br />

excreted. 4,5<br />

Isomalt as a tooth-friendly sugar<br />

replacer<br />

Isomalt is another low-glycaemic carb which<br />

BENEO derives from sugar beet. It is the only<br />

sugar replacer made from this plant, but<br />

with half as many calories as sucrose and<br />

an almost negligible effect on blood sugar<br />

and insulin levels. Isomalt is well-suited for<br />

the confectionery segment, as it has a sugarlike,<br />

mild taste that enhances subtle flavours<br />

but has no aftertaste or cooling effect associated<br />

with some sweeteners. The mild<br />

sweetness leads to a more intense aroma.<br />

Isomalt provides bulk and texture, too, and<br />

can replace conventional sugar in the same<br />

proportion in numerous applications within<br />

the confectionery and bakery segments. In<br />

products such as cookies, cakes, chews and<br />

jellies, Isomalt contributes to a good texture.<br />

It also supports the whiteness in coatings.<br />

40 No. 3 November/December <strong>2023</strong>

Sweetening alternatives<br />

In the field of sugar replacers, Isomalt offers<br />

another important feature: It is tooth-friendly,<br />

as demonstrated by an official EU health<br />

claim. Studies have shown that the sugar<br />

substitute does not nourish caries bacteria<br />

and reduces the development of plaque.<br />

These properties qualify Isomalt for use in<br />

tooth-friendly versions of chewing gums,<br />

candies and other confectionery – and<br />

contribute to their popularity: Isomalt is the<br />

most widely used sugar replacer in sugarfree<br />

hard candies worldwide.<br />

Putting it into practice<br />

While a healthier product is appealing to<br />

many consumers, it will only succeed on<br />

the market if it delivers the right indulgence.<br />

Reducing or replacing conventional sugar<br />

should therefore involve sensorial and technological<br />

considerations. By removing sugar,<br />

product qualities such as bulk, mouthfeel<br />

and texture can be negatively impacted.<br />

Ingredients must therefore be added back in<br />

to create a pleasing product for consumers.<br />

To ensure that the end product tastes as good as usual, but is healthier<br />

than before, specialists at the BENEO-Technology Center conduct<br />

regular recipe trials that also undergo stringent sensorial evaluation,<br />

to guarantee that they will deliver in terms of taste and texture. Reformulating<br />

products in order to lower their sugar content or focus on<br />

a low-glycaemic effect, requires the close collaboration of manufacturers<br />

and functional ingredients experts.<br />

References<br />

1<br />

https://www.who.int/news/item/15-05-<strong>2023</strong>-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline<br />

2<br />

International Diabetes Federation, Diabetes Atlas 9th Edition (2019)<br />

3<br />

Otsuka et al. (2021) Int J Environ Res Public Health 18(11). https://pubmed.ncbi.nlm.nih.<br />

gov/34072006/<br />

4<br />

Takada et al (2022) Eur J Appl Physiol 22(12):2615-2626. doi: 10.1007/s00421-022-<br />

05044-9<br />

5<br />

Amano et al. (2022) Physiol Behav. 249:113770. https://doi.org/10.1016/j.physbeh.2022.113770<br />

For more information, please contact<br />

Klaudia Volmer, Product Manager<br />

Functional Carbohydrates<br />

BENEO GmbH<br />

Phone: +49 621 421-150<br />

contact@beneo.com<br />


Healthy ageing<br />

Photo © : GoodMills Innovation<br />

Spermidine science: unlocking the secrets<br />

to healthy ageing<br />

Katharina Ursula Haack<br />

A growing body of scientific evidence is driving interest in spermidine<br />

as an active ingredient for inclusion in healthy ageing<br />

products. Max Weber, Category Manager Baking, Snacks &<br />

Special Ingredients at GoodMills Innovation GmbH, summarises<br />

the science behind this remarkable compound and examines<br />

the opportunities for incorporating it into marketable food,<br />

beverage and supplement concepts.<br />

In recent years, healthy ageing has become one of the most dynamic<br />

areas of health science, with researchers working to discover new<br />

insights that can help people to live longer and healthier. For example,<br />

researchers are currently investigating telomere length, DNA damage<br />

and inflammation as biomarkers of ageing in order to better understand<br />

the ageing process and develop healthy ageing interventions.<br />

Cell renewal science<br />

One of the biggest breakthroughs in age related health science in<br />

recent history has been Yoshinori Ohsumi’s research into the mechanisms<br />

behind autophagy.<br />

The word autophagy originates from the<br />

Greek words auto and phagein, (meaning<br />

‘self eating’). This concept emerged during<br />

the 1960s, when researchers first observed<br />

that a cell could recycle its contents.<br />

Difficulties in studying the phenomenon<br />

meant that little was known until Ohsumi, of<br />

the Tokyo Institute of Technology, focused his<br />

efforts on this process. Ohsumi’s research<br />

led to a new paradigm in autophagy science<br />

and in 2016 he was awarded the Nobel Prize<br />

in Physiology or Medicine for his discoveries<br />

of mechanisms for autophagy.<br />

Via these mechanisms, damaged organelles<br />

(subcellular structures that perform specific<br />

tasks in the cell) are recycled and used in<br />

the biosynthesis of new cell generation, thus<br />

promoting sustained cell health.<br />

42 No. 3 November/December <strong>2023</strong>

Healthy ageing<br />

Thanks to the research carried out by<br />

Ohsumi and others, the scientific community<br />

now has a better understanding of how<br />

autophagy controls important physiological<br />

functions where cellular components need<br />

to be degraded and recycled.<br />

Autophagy and ageing<br />

Scientists also established that autophagy<br />

is an important process for healthy ageing.<br />

Defects in the autophagy process have been<br />

associated with immunity loss, cognitive loss<br />

and ageing. Autophagy is thought to protect<br />

against diseases and slow down the ageing<br />

process.<br />

The next challenge was working out what<br />

interventions could promote autophagy<br />

activity. This is where spermidine - a polyamine<br />

that that occurs naturally in all living<br />

organisms, including plants, foodstuffs,<br />

mammals and men - comes into play.<br />

Through its interactions with cell metabolism,<br />

spermidine has been characterised by scientists as a natural<br />

autophagy inducer, and, in this capacity, has been shown to act as<br />

an ‘anti-ageing agent’.<br />

Spermidine under investigation<br />

Today, there is a robust and ever-expanding body of research<br />

pertaining to spermidine’s role in many of the molecular mechanisms<br />

involved in ageing. To date over 13,000 studies have been carried out<br />

on spermidine, of which approximately 70 are human clinical trials.<br />

Photo © : GoodMills Innovation

Healthy ageing<br />

Photo © : GoodMills Innovation<br />

About 100 scientific laboratories are currently investigating spermidine<br />

and its effects. Having established its anti-ageing functionality,<br />

research is now evolving to explore the mechanisms responsible,<br />

as well as spermidine’s role in specific health areas, such as heart<br />

disease, cancer, immunity, dementia and longevity.<br />

High spermidine levels for a longer life<br />

One of the most interesting findings was the discovery in 2012 that<br />

the endogenous spermidine level decreases with age, especially after<br />

60, but that very old people, over 90, have very high levels 1 . This<br />

might seem paradoxical but actually makes perfect sense - those with<br />

high spermidine levels live longer.<br />

Another more recent study involving 829 participants aged 45-84<br />

found that a spermidine-rich diet can add five years onto a person’s<br />

lifespan 2 . The researchers said the study provided the first evidence<br />

of an association between nutrition rich in spermidine and increased<br />

survival in humans.<br />

“If confirmed in future intervention trials, our study may have implications<br />

for health education at a population level advocating high spermidine<br />

content as a novel feature of a healthy diet,” the researchers<br />

wrote in The American Journal of Clinical Nutrition.<br />

Lifespan and healthspan:<br />

protecting cognitive performance<br />

But a long lifespan is just one dimension of healthy ageing - quality of<br />

life is as important as quantity. To this end, spermidine also appears<br />

to have positive effects on age-related neurological disorders and<br />

cognitive impairment.<br />

The Vienna Dementia Study in 2021 3 was a major milestone in<br />

establishing a clear correlation between intake of spermidine and<br />

the improvement of cognitive performance in seniors with no or<br />

mild dementia. 85 seniors from six nursing homes participated in<br />

the multi-centre, double-blind study, which showed improved cognitive<br />

performance after just three months of spermidine supplementation.<br />

This corroborated findings that spermidine supplementation<br />

increases memory performance in a similar<br />

study carried out at Charité in 2018 4 .<br />

Meeting demand for anti-ageing solutions<br />

As global populations grow older, and the<br />

prospect of living into their eighties or nineties<br />

becomes a realistic expectation for many<br />

people, demand for nutritional solutions that<br />

can help support long, healthy, active lifestyles<br />

is poised to surge in the next few years.<br />

A recent market intelligence report predicted<br />

a CAGR (Compound Annual Growth Rate) of<br />

5.23 % for anti-ageing supplements globally<br />

between <strong>2023</strong> and 2028.<br />

As one of the most researched active<br />

compounds, spermidine is likely to play a<br />

starring role in the healthy ageing revolution.<br />

However, this is dependent on food,<br />

beverage and supplement manufacturers<br />

having an application-ready source of spermidine<br />

at their disposal.<br />

In order to satisfy changing consumer<br />

pre ferences, it is also important that spermidine<br />

is available in plant-based, veganfriendly<br />

formats. The same report highlights<br />

plant-based supplements as a significant<br />

growth opportunity in this space as<br />

consumers seek natural, sustainable and<br />

additive-free products.<br />

Natural extraction<br />

SpermidineEvo ® delivers on both fronts. It<br />

is sourced from wheat germ, which has the<br />

highest spermidine concentration of any<br />

plant-based foodstuff - higher than soybeans,<br />

buckwheat and rice. The wheat germ is<br />

well protected inside the wheat kernel and<br />

accounts for approximately 2.5-3.5 % of<br />

the total kernel. GoodMills has optimised<br />

the milling process to separate the germ,<br />

bran and other grain components. A gentle<br />

thermal treatment improves the stability of<br />

the wheat germ. This is followed by a milling<br />

process to produce a fine powder with an<br />

aromatic, nutty taste. This highly concentrated<br />

form of wheat germ has a tightly<br />

controlled spermidine content - up to five<br />

times as much as conventional wheat germs.<br />

44 No. 3 November/December <strong>2023</strong>

Healthy ageing<br />

2 g of SpermidineEvo ® provides a 1 mg dose<br />

of spermidine.<br />

The ingredient also contains other valuable<br />

vitamins and minerals, including vitamin E,<br />

which has long been considered a key antiaging<br />

ingredient owing to its proven ability to<br />

protect cells against oxidative damage.<br />

Importantly, SpermidineEvo ® is not classed<br />

as a Novel Food, which means no regulatory<br />

approval is needed to incorporate it<br />

into foods and beverages destined for sale<br />

in the EU.<br />

Psychographic segmentation<br />

Whilst finding the right ingredients is a challenge<br />

for product developers, for marketers,<br />

the challenge is figuring out what kinds<br />

of healthy ageing products will capture<br />

consumer interest and imagination.<br />

Market research shows that healthy ageing<br />

is a very relevant topic for all age groups, not<br />

just seniors. That is why GoodMills Innovation<br />

is advising customers to use a psychographic<br />

segmentation approach when it<br />

comes to finding the right audience for their<br />

products.<br />

Lifestyle consumers, for example, seem<br />

to be a natural target, as maintaining their<br />

physical and cognitive health as they age is<br />

of high importance to them and they have<br />

the spending power to put it into practice.<br />

When targeting a more mature audience,<br />

brands should also take account of the fact<br />

that ‘old’ people don’t want to view themselves<br />

as ‘old’. Therefore, products need<br />

to be geared towards age-neutral audiences<br />

and focus on aspirational values, with<br />

preventative health and positive ageing at<br />

the forefront of communication.<br />

Keeping products age-neutral also means<br />

that brands are likely to attract a broader<br />

audience. In Innova’s 2021 Health & Nutrition<br />

Survey, 66 % of consumers globally<br />

said that healthy ageing was very/extremely<br />

important to them. That represents a large<br />

potential market.<br />

Whilst seniors are the most obvious target for healthy-ageing products,<br />

younger consumers are increasingly switched on to the idea<br />

of taking proactive action to slow the ageing process. According to<br />

the same Innova survey, almost 50 % of Generation Z consumers<br />

reported taking steps to age healthily from the age of 20.<br />

A powerful product development tool<br />

Consumers want to live longer and better, and nutrition is one of the<br />

most promising strategies for promoting healthy ageing. Spermidine’s<br />

role in maintaining physical and cognitive health through its ability to<br />

influence autophagy is well documented, making it a prime candidate<br />

for the job. Providing the crucial link between academic research and<br />

real world product development, SpermidineEvo ® enables manufacturers<br />

to develop powerful products that harness spermidine science<br />

and market demand for healthy ageing solutions.<br />

References<br />

1<br />

Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S,<br />

Mignini F, Napolioni V. Spermidine and spermine are enriched in whole blood of nona/centenarians.<br />

Rejuvenation Res. 2012 Dec;15(6):590-5. doi: 10.1089/rej.2012.1349. Epub 2012<br />

Nov 16. PMID: 22950434.<br />

2<br />

Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl<br />

C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic<br />

S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J.<br />

Higher spermidine intake is linked to lower mortality: a prospective population-based study.<br />

Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. PMID: 29955838.<br />

3<br />

Pekar T, Bruckner K, Pauschenwein-Frantsich S, Gschaider A, Oppliger M, Willesberger J,<br />

Ungersbäck P, Wendzel A, Kremer A, Flak W, Wantke F, Jarisch R. The positive effect of spermidine<br />

in older adults suffering from dementia : First results of a 3-month trial. Wien Klin<br />

Wochenschr. 2021 May;133(9-10):484-491. doi: 10.1007/s00508-020-01758-y. Epub 2020<br />

Nov 19. PMID: 33211152; PMCID: PMC8116233.<br />

4<br />

Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic<br />

S, Madeo F, Flöel A. The effect of spermidine on memory performance in older adults at risk<br />

for dementia: A randomized controlled trial. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.<br />

cortex.2018.09.014. Epub 2018 Oct 4. PMID: 30388439.<br />

5<br />

https://www.marknteladvisors.com/research-library/anti-aging-supplements-market.html<br />

For more information, please contact<br />

Katharina Ursula Haack,<br />

Head of Marketing Communications,<br />

GoodMills Innovation GmbH<br />

Trettaustr. 35<br />

21107 Hamburg, Germany<br />

Katharina.Haack@goodmillsinnovation.com<br />

www.goodmillsinnovation.com<br />

No. 3 November/December <strong>2023</strong><br />


Energy and endurance<br />

Photo © : GELITA<br />

Equipping the body to push harder for longer<br />

GELITA introduces the first protein ingredient targeted at endurance sports<br />

Oliver Wolf<br />

Whether it’s a marathon, a triathlon, a team event like football<br />

or a high intensity gym-based workout, sports that test<br />

endurance may differ in specifics, but they share a common<br />

denominator: they place extreme demands on the body over<br />

a sustained period of time.<br />

Traditionally, because endurance sports rely heavily on aerobic<br />

metabolism, nutrition products aimed at participants have been rich<br />

in carbohydrate, which is sometimes referred to as ‘the master fuel’.<br />

However, carbohydrates are not the whole story. Endurance performance<br />

also requires protein, and a new product from collagen manufacturer<br />

GELITA aims to fill a gap in the market with a specific type of<br />

protein with particular benefits in this respect.<br />

A growing market<br />

Consumer interest in endurance activities is growing, and online platforms<br />

and Apps encouraging people to come together in events and<br />

track their individual progress are booming.<br />

Strava, said to be the world’s largest sports<br />

community, recently published a review of<br />

data from its 100 million-plus members,<br />

which showed that the number of runners<br />

who completed a marathon in 2022 was<br />

almost twice as high as in 2021 (1). And<br />

when events booking platform Let’s Do This<br />

secured $60 million in new funding last year,<br />

co-founder Sam Brown said: “The global<br />

sports endurance market is worth an estimated<br />

$18 billion… we know this is only set<br />

to grow.”<br />

In terms of sports nutrition products, analysts<br />

at Future Market Insights (FMI), valued the<br />

global market at around USD 30.6 billion in<br />

2022. By 2032, FMI expects it to have more<br />

than doubled in value, to be worth around<br />

USD 64 billion.<br />

46 No. 3 November/December <strong>2023</strong>

Energy and endurance<br />

North America leads the way in consumption<br />

of sports nutrition products, with the<br />

UK, Germany and France the next biggest<br />

markets, and Asia-Pacific predicted to be<br />

the fastest growing region over the next 10<br />

years (2).<br />

“Consumers are treating their bodies like<br />

an ecosystem and seeking solutions that<br />

complement their personal health and<br />

evolving needs,” says FMI. “Consumer<br />

needs have become more diverse and<br />

sophisticated and are defining premium<br />

growth categories.”<br />

Products targeting endurance sports look<br />

likely to be one of these premium growth<br />

categories – not only because more people<br />

are taking part, but also because participants<br />

often have high levels of disposable<br />

income. In an article entitled ‘Why<br />

rich people love triathlons’, for instance,<br />

personal trainer Alexander Cortes says:<br />

“Endurance sports are very popular in the<br />

highest income brackets… It’s a mixture<br />

of psychology, social status signaling and<br />

prestige, and environmental luxury.” (3)<br />

Already, the market offers endurance<br />

sports participants an abundance of carbohydrate-rich<br />

foods and drinks that supply<br />

an instant boost of energy. But until now,<br />

there hasn’t been a targeted protein solution<br />

that offers long-lasting, foundational<br />

benefits that can help them to push harder<br />

and perform better in a sustained way.<br />

Protein for endurance<br />

Adequate protein intake is essential for performance. Proteins are<br />

vital building blocks for the structure and metabolism of muscle,<br />

bone and connective tissue. Proteins and amino acids also play a<br />

key role in cellular metabolism, hormone balance, immunity, coagulation<br />

and energy metabolism.<br />

In terms of sports nutrition, proteins are often reported to have<br />

positive effects on muscle protein synthesis, muscle mass, muscle<br />

strength, improvement of body composition, prevention of catabolic<br />

state, immune competence and optimal regeneration in the<br />

post-exercise phase (4).<br />

GELITA’s new product, PeptENDURE ® , harnesses the benefits of<br />

a specific set of Bioactive Collagen Peptides (BCP ® ) with a unique<br />

ability to provide long-term adaptation benefits for endurance athletes<br />

in particular.<br />

What is PeptENDURE ® ?<br />

PeptENDURE ® is composed of functional short chain amino acids<br />

produced by simple hydrolysis of natural collagen protein. But rather<br />

than simply building muscle like a traditional protein supplement, it<br />

delivers foundational changes.<br />

PeptENDURE ® has been shown in two studies and in practice to<br />

improve energy metabolism, endurance and cardiovascular fitness<br />

so that athletes find it easier to push harder and perform better.<br />

“PeptENDURE ® isn’t just another ‘quick fix’ product – it is something<br />

different that allows athletes to see long-term performance benefits,”<br />

says Martin Walter, Category Manager Healthy Aging & Sports Nutrition<br />

at GELITA. “Our research suggests that PeptENDURE ® promotes<br />

adaptative changes in the mitochondria. This is supported by two<br />

placebo controlled clinical trials, where results were impressive.”<br />















Food ingredients<br />

<br />

28-30 november <strong>2023</strong><br />

Frankfurt (Germany)<br />

No. 3 November/December <strong>2023</strong><br />


Energy and endurance<br />

In the first trial, young, active women took either a daily dose of<br />

PeptENDURE ® or placebo for 12 weeks, alongside concurrent resistance<br />

and endurance training three times a week. At the end of 12<br />

weeks, both groups completed a one-hour running time trial. The<br />

results showed that the PeptENDURE ® group ran significantly further<br />

than the placebo group (+331 m) and also had a significant increase<br />

Fig. 1: After 12 weeks in the women’s study, the PeptENDURE ® group was<br />

not only faster than baseline, but also ran 331m more than the placebo<br />

group in a one-hour time trial.<br />

in fat-free mass. There were also visible<br />

improvements such as improved aerobic<br />

metabolism, improved heart rate and higher<br />

individual anaerobic thresholds (5).<br />

In the second trial, the same study design<br />

followed young, active men. Participants<br />

took either a daily dose of PeptENDURE ® or<br />

a placebo for 12 weeks, alongside concurrent<br />

resistance and endurance training three<br />

times a week. At the end of the 12 weeks, the<br />

PeptENDURE ® group ran significantly further<br />

(+662 m) in the one-hour time trial than the<br />

placebo group. In addition, the fat mass of<br />

the intervention group decreased and the<br />

lactate threshold improved significantly, indicating<br />

increased fat metabolism (6).<br />

“Overall, the trials showed that participants<br />

who took PeptENDURE ® were able to run 14<br />

percent faster compared to baseline, which<br />

could be the difference between finishing<br />

fifth in a race and finishing first,” says Martin<br />

Walter.<br />

Characteristics and applications<br />

Fig. 2: The men who took PeptENDURE ® for 12 weeks were faster than at<br />

baseline and ran significantly more in one hour (662m) than those who took<br />

placebo.<br />

Like all GELITA BCP ® , PeptENDURE ® is a<br />

pure white, neutral-tasting powder. It comes<br />

in agglomerated form for dust-free handling,<br />

combines well with other micronutrients such<br />

Due to its excellent solubility, PeptENDURE ® is perfectly suited for ready-to-drink products. (Photo © : GELITA)<br />

48 No. 3 November/December <strong>2023</strong>

Energy and endurance<br />

as vitamins and minerals and has excellent<br />

bioavailability. Recommended intake is 15 g<br />

daily for at least three months.<br />

GELITA expects powder supplements to be<br />

the core application format for PeptENDURE ®<br />

as it dissolves quickly and easily in water and<br />

other drinks. There’s no need for a blender or<br />

other complicated routine – users simply stir<br />

and go. The powder can also be mixed with<br />

other foods, such as yogurt, for example, for<br />

breakfast in the morning with cereals.<br />

Being 100 percent natural and free from<br />

E-numbers, PeptENDURE ® is ideal for clean<br />

label products, and it can be customised<br />

with different flavors and levels of sweetness.<br />

PeptENDURE ® also works well in ready-todrink<br />

concepts, gels and nutrition bars.<br />

GELITA is a leader in collagen peptide<br />

science and has many years of experience<br />

in sports nutrition. “Safety is always<br />

our top priority with all of our products, and<br />

PeptENDURE ® is no different,” says Martin<br />

Walter. “Its safety has been well documented<br />

in human and animal studies. It is non-allergenic,<br />

non-GMO, gluten-free, GRAS and<br />

accepted by the World Anti-Doping Agency,<br />

so athletes can consume it with confidence.”<br />

Positioning and potential<br />

PeptENDURE ® can be used as an everyday training partner for athletes in all<br />

endurance sports, from long-distance running, cycling and triathlon to team<br />

sports and high-intensity gym-based activities.(Photo © : GELITA)<br />

running and triathlon to team sports and high-intensity gym-based<br />

activities. This makes it appealing for a wide range of consumers and<br />

brings manufacturers many benefits, including the ability to expand<br />

their sports nutrition portfolio with high value products.<br />

GELITA’s technical application service team supports manufacturers<br />

and supplement brands regarding product applications, regulatory<br />

or technical issues. GELITA can also offer support with marketing<br />

advice.<br />

As PeptENDURE ® is different to other sports<br />

nutrition ingredients, it can be seen as an<br />

‘add on’ product for athletes, rather than an<br />

alternative. It could, for instance, be positioned<br />

as a ‘Daily Adaptation’ product that<br />

forms part of an endurance-based training<br />

program.<br />

PeptENDURE ® can also be positioned as part<br />

of a ‘Competition Bundle’, where products<br />

are collated for consumers looking to<br />

embrace a period of training ahead of a<br />

new goal, or as a ‘Training Partner’ offering<br />

holistic support that equips users to take on<br />

any challenge.<br />

Unlike anything else on the market,<br />

PeptENDURE ® has the potential to become<br />

the everyday training partner for participants<br />

in all endurance sports – from long-distance<br />

References<br />

(1) Strava, Year in Sport 2022. https://www.strava.com/yis-community-2022 [Last<br />

accessed 10.10.<strong>2023</strong>]<br />

(2) Future Market Insights ‘Capitalizing on the trends shaping the sports nutrition market:<br />

<strong>2023</strong> and beyond!’ Presented at Vitafoods Europe 2022. https-//www.futuremarketinsights.<br />

com/blogs/sports-nutrition-market-<strong>2023</strong>.pdf [Last accessed: 11.10.<strong>2023</strong>].<br />

(3) https://cortes.site/why-rich-people-love-triathlons/ [Last accessed 12.10.23]<br />

(4) Koenig et al. (2020): Proteins in sports nutrition. Position of the working group sports<br />

nutrition of the German Nutrition Society (DGE). Ernahrungs Umschau 2020; 67(7): 132–9.<br />

DOI: 10.4455/eu.2020.039<br />

(5) Jendricke et al. (2020): Influence of Specific Collagen Peptides and Concurrent Training<br />

on Cardiometabolic Parameters and Performance Indices in Women: A Randomized<br />

Controlled Trial. Front Nutr. 2020 Nov 19;7:580918. doi: 10.3389/fnut.2020.580918.<br />

(6) Jerger et al. (in preparation)<br />

For more information, please contact<br />

Oliver Wolf<br />

Marketing EMEIA,<br />

Business Unit Nutrition & Health Ingredients<br />


Oliver.Wolf@gelita.com<br />

www.gelita.com<br />

No. 3 November/December <strong>2023</strong><br />


Obituary<br />

Au Revoir Edouard<br />

We mourn the loss of our friend and partner - Edouard Costemend<br />

Photo © : Adobe Stock/AlenKadr<br />

For decades Edouard has been the representative of <strong>Wellness</strong> <strong>Foods</strong><br />

& <strong>Supplements</strong> and other journals of the Dr. Harnisch publishing<br />

house in France.<br />

Born in Lille in 1937, married to Marie-Christine since 1977, he had<br />

two children, Benjamin and Constance. In 2022 he became the<br />

happy grandfather of his first grandchild.<br />

He had been taught the German language and culture by his father, a<br />

medical doctor. His first internship took him to Leica in Wetzlar, where<br />

he developed his passion for Leica and photography.<br />

For 28 years he worked for Gustav Elm, an advertising agency in<br />

Paris, which represented, among others, the magazine DER SPIEGEL<br />

in France. Since 1993 he has been working independently with<br />

his company AD PRESSE International, since 2000 exclusively for<br />

Dr. Harnisch Verlag. His son Benjamin has meanwhile succeeded<br />

him as area representative for France.<br />

In addition to his professional activities, Edouard Costemend was an<br />

umpire at the French Open Tennis Championships at Roland Garros.<br />

Furthermore, he was characterized by lively cultural and political<br />

interests.<br />

Edouard Costemend was a noble, impressive man; he was trusted<br />

and held in high esteem everywhere. His integrity was a benchmark<br />

for all his colleagues. At the same time Edouard could be very funny<br />

and had a warm sense of humor. He was a wonderful host whenever<br />

we met in Paris and he loved showing the team different special<br />

places, away from the more tourist areas.<br />

Edouard Costemend (*1937-<strong>2023</strong>)<br />

We lose a valued friend and good partner<br />

and will miss him greatly.<br />

Our sympathy goes to his family,<br />

Marie-Christine, Benjamin and Constance.<br />

Benno Keller, Publisher<br />

Silke Watkins, Editor-in-Chief<br />

Impressum<br />

ISSN 2364-8104<br />

<strong>Wellness</strong> <strong>Foods</strong> & <strong>Supplements</strong> | No. 3/<strong>2023</strong><br />

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International Magazine September 2022 ISSN 2628-5851<br />

Technology & Marketing<br />

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