The Staphylococcus aureus secretome - TI Pharma

Appendix III Supplemental Table IIIj
PID Protein -3 -2 -1 +1 Function
82751035 EbhB V D A A truncated cell surface fibronectin-binding protein
82751071 a GpsA S R A N glycerol-3-phosphate dehydrogenase
82751144 SAB1412c V N A E hypothetical protein
82751320 i Fhs S Y A Q surface-anchored iron-regulated surface protein
82751393 j SplE D K A E serine proteinase
82751394 a SplC A Y A N serine proteinase
82751395 k SplB A K A E serine proteinase
82751397 SAB1675 S L A D hypothetical protein
82751401 EpiP A N A E serine protease precursor
82751408 LukD A F A Y leukotoxin D subunit
82751409 LukE A S A A leukotoxin E subunit
82751419 SEN A K A E enterotoxin N
82751421 SEI S Y A K enterotoxin I
82751422 SEO T Q A N enterotoxin O
82751535 a SAB1814 V E A K hypothetical protein
82751566 a SspB2 A H A S staphopain cysteine proteinase
82751581 a SAB1860c A S A D hypothetical protein
82751594 Map A H A S cell surface protein
82751595 SAB1874 A D A A β-hemolysin
82751596 a SAB1875c V A A K leukocidin F subunit
82751597 a SAB1876c A K A S leukocidin S subunit
82751634 a SAB1916c S K A E membrane anchored Ser-Asp rich fibrinogen-binding protein
82751697 a SAB1980c A K A A hypothetical protein
82751757 b FmtB A N A E truncated methicillin resistance-related surface protein
82751802 a SAB2085 A Y A H hypothetical protein
82751888 a SsaA S H A A secretory antigen precursor
82751892 a SAB2176 V K A K exported secretory antigen precursor
82751903 a SAB2187c A Q A A transcriptional regulator
82752013 a Sbi A H A A immunoglobulin G-binding protein
82752015 a HlgA A L A I γ-hemolysin component A precursor
82752016 a HlgC I Y A A γ-hemolysin component C
82752017 a HlgB A Y A D γ-hemolysin component B
82752118 a SAB2409c A N A D hypothetical protein
82752126 a SAB2418 A Q A T secretory antigen SsaA-like protein
82752129 c SAB2421c A N A A hypothetical protein
82752147 a SAB2439c A H A Q secretory antigen precursor
82752151 a IsaA S N A A immunodominant antigen A
82752211 a,b ClfB A Q A A clumping factor B
82752218 a Aur V N A A zinc metalloproteinase aureolysin
82752220 a SAB2514 A S A A hypothetical protein
82752225 a SAB2519 A Q A S N-acetylmuramoyl-L-alanine amidase
82752227 a,c SasF A Q A A surface anchored protein
82752246 a IcaB A H A D intercellular adhesion protein B
82752249 a Lip A N A A triacylglycerol lipase precursor
a
Proteins belonging to the S. aureus core proteome
b
Proteins with an LPxTG-motif
c
Proteins that are only present in S. aureus RF122
d
Proteins with an LPxAG-motif
e
The S. aureus RF122 protein has an Ile on the -2 position, which is not included in the recognition and
cleavage pattern; all other S. aureus strains are conform the proposed pattern
f
Proteins with a LysM or GW domain motif
g
Only the S. aureus RF122 protein is truncated at the N-terminus, thereby missing part of the signal peptide
h
The S. aureus RF122 protein is truncated at the C-terminus, therefor missing the LPxTG motif
i
The S. aureus RF122 protein has an Asp on the -3 position , which is not included in the
j
The S. aureus RF122 protein has an Asp on the -3 position , which is not included in the recognition and
cleavage pattern; the MRSA252 protein is conform the proposed pattern
k
Only the S. aureus RF122 protein is predicted to have two membrane domains
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