Newsletter_03-2025_EN

EN 03/25

Taking Finnish

Cleanroom Expertise

to the World

TITLE

Taking Finnish Cleanroom

Expertise to the World

Finnish companies have special expertise in the design, construction and turnkey

deliveries of cleanrooms. Now the Finnish business consortium wants to export

its expertise to the world and find out how the sustainability of cleanrooms

can be improved.

Cleanrooms are essential for many crucial

processes. For example, laboratories and

production facilities require strictly regulated

environments in electronics, pharmaceuticals,

biotechnology, food, and semiconductor

industries, as well as in hospital

pharmacies, operating rooms, and the optical

industry.

Cleanrooms are classified according to

ISO into classes 1–9, and according GMP

into classes A to D. Each class defines how

clean the air must be, specifying how many

particles are allowed per cubic meter of air.

The standard’s requirements must be meticulously

followed, and everything must be

thoroughly documented. In pharmaceutical

cleanrooms, microbiological contamination

must also be measured and controlled.

In practice, clean air is achieved through

effective ventilation. Consequently, cleanrooms

are highly energy-intensive spaces.

To enhance their energy efficiency, the sizing

and regulation of their ventilation systems

need to be demand-oriented. Modern

solutions can also reduce the use of chemicals

in cleanrooms, providing a more environmentally

sustainable option.

Internationalization and entering new

markets can be challenging for individual

companies. The ASC alliance (Alliance for

Sustainable Cleanrooms) was established

to meet the internationalization objectives

of cleanroom industry participants, building

on the success of previous collaborative

projects.

“Clients ordering cleanroom solutions

often seek turnkey deliveries. With this setup,

it’s more than achievable,” says Jukka

Vasara, the vice president at Granlund, who

initiated the alliance.

Cleanroom clients typically have two

main priorities: the project must be completed

quickly and on schedule, and the quality

must always be top-notch. Errors and disruptions

can become incredibly costly due

to production disturbances.

Jukka Vasara states that the alliance’s

strength lies in decades of expertise in

design, project management, and system

capabilities, alongside technological excellence:

for instance, Finnish ventilation technology

is world-class.

High demands in cleanrooms

Info: ASC – Alliance for Sustainable

Cleanrooms

The ASC combines the specialized expertise

of its member companies in cleanroom

technology, enabling them to provide comprehensive

solutions for customers in international

markets. With Group Explorer funding

from Business Finland, the alliance can

explore new global opportunities, expanding

market access and building a stronger

international presence.

Members and sectors of the alliance:

– Granlund, cleanroom design

– Halton, ventilation solutions

– Vaisala, monitoring and

measurement solutions

– Cleamix, decontamination solutions

– LED Tailor, blue light solutions

– Hermetel, cleanroom elements

– Zeus Tech, validation, measurement,

and testing solutions

– Kavika HealthCare, furniture solutions

Halton Group

FI 00240 Helsinki

www.reinraum.de | www.cleanroom-online.com NEWSLETTER | Edition EN 03-2025

page 2/41

March 2025

Precise Attachment and

Reliable Sensing

Often the most easily overlooked things turn out to be among the most

useful. The sensor holders GN 801.3 and GN 801.4 are perfect examples.

These add-on elements help enable position monitoring for many types

of toggle clamps and therefore play an important role in process reliability.

These standard parts consist of two pieces: the retaining bracket,

which is easily attached using the bores already present on the toggle

clamp, and the retaining plate with the bore for the sensor itself. The plate

can be quickly affixed to the bracket with setting nuts and features

an elongated hole for precise adjustment of the sensor and its switching

point. Because no new mounting bores are required, the sensor holder

is ideal for quickly upgrading existing installations. It does not matter

whether the toggle clamp is oriented vertically or horizontally, whether

it has a locking lever or whether the sensor holder needs to be attached

on the right or left side. This last aspect is especially worth highlighting

as the position of the setting nuts can be chosen during installation to

mount the sensor holder on the left or right of the toggle clamp.

The sensor holder is compatible with all typical inductive sensors

with M8 thread. To make it even simpler to upgrade or build secured

mechanisms, Ganter also offers the sensor holders as a complete unit

including sensor. The sensor has a three-pole M8 plug, can be operated

with 10-36 V direct current and indicates via LED as well as a high signal

when the toggle clamp has securely arrived at the end point.

This is the case when the knee lever of the clamp has passed the

so-called dead point. Sensing methods implemented in this way rule out

the possibility of workpieces remaining improperly secured in partially

or fully automated systems. The stability of the process is enhanced in

this way, which also increases a company’s quality and economic performance.

Dear cleanroom professionals,

if the Shipping company has done a good job,

you should have been in possession of the

REINRAUM YEARBOOK 2025 and the

book of the REINRAUM EXPERTS 2025.

I hope you are just as enthusiastic as a

customer who called me and said “that‘s

a hell of a lot of information. Nobody can read it

all. I leafed through it and made dog-ears on the

pages I still want to read at my leisure”.

I think that‘s a good idea.

In three weeks, the LOUNGES will be in

Karlsruhe. Just come and see us at our stand.

I look forward to seeing you there.

In the meantime, we have some interesting

information again:

> Taking Finnish Cleanroom

Expertise to the World

> Precise Attachment and Reliable Sensing

> New subsidiary for ZETA in Poland

> Production optimization through

new ASYS Technologies

> Finding Better Photovoltaic

Materials Faster with AI

> The power of sound

waves for stable cleanliness

> Energy Efficiency in Pharmacy

Cleanrooms

> . . .

With kind regards

Reinhold Schuster

Otto Ganter GmbH & Co. KG

Triberger Straße 3

D 78120 Furtwangen

Telefon: +49 7723 65070 Telefax: +49 7723 4659

eMail: info@ganternorm.com Internet: http://www.ganternorm.com


page 3/41

Artistic representation of the Milky Way based

on data from ESA‘s Gaia space telescope.

© ESA/Gaia/DPAC, Stefan Payne-Wardenaar

Jena research shapes knowledge about our galaxy

Farewell to Gaia:

Space mission to measure

the Milky Way comes to an end

Artist‘s impression of Gaia observing the Milky Way.

© Spacecraft: ESA/ATG medialab;

Milky Way: ESA/Gaia/DPAC; CC BY-SA 3.0 IGO.

Acknowledgement: A. Moitinho.

Since its launch, the European Space Agency‘s (ESA) Gaia

space mission has provided detailed images of our home galaxy,

the Milky Way. After more than a decade, its fuel tank

is almost empty, and the mission is coming to an end. Jena

technology also played a role: Researchers from the Fraunhofer

Institute for Applied Optics and Precision Engineering

IOF developed a key component for one of the spectrometers

on board that was able to withstand even extreme

conditions in space.

Since its launch in December 2013, the Gaia space probe has mapped

the positions, distances, movements and numerous other features

of stars and other celestial bodies in our galaxy. The mission

aimed to create the most detailed map of the Milky Way to date and

gain unique insights into our cosmic home.

After 11 years and around three trillion observations of approximately

two billion stars, the mission is coming to an end. Gaia will

end its scientific observations in January 2025.

Cutting-edge technology for exploring the Milky Way

Three instruments on board Gaia make it possible to map the Milky

Way. One of them is the „Radial Velocity Spectrometer“ (RVS), whose

key component, a transmission grid for measuring redshift, was

developed at Fraunhofer IOF.

The redshift measures the direction and speed of movement

of stars. In order to meet the high requirements of the mission, the

Fraunhofer researchers combined the principle of optical metamaterials

with high-resolution lithographic structuring technology.

The instruments have to withstand extreme conditions: vibrations

during rocket launches, strong temperature fluctuations in orbit

or, for example, exposure to micrometeorite impacts. To overcome

this challenge, the researchers at Fraunhofer IOF successfully collaborated

with colleagues from the Institute of Applied Physics in

Jena. As a result, Gaia delivered precise measurement data even after

11 years in space.

New perspectives on the Milky Way

The data collected by Gaia has fundamentally expanded our knowledge

of the Milky Way. In particular, the observations of star movements,

distances and their distribution have provided new insights

into the formation and development of the galaxy.

In addition to mapping stars within our galaxy, Gaia has also

observed objects outside the Milky Way. From asteroids in the solar

system to distant galaxies, the mission has provided valuable data.

One last look at Gaia

Even though the scientific observations have been completed,

Gaia‘s mission is not yet complete. Various technology tests are

planned for the coming weeks before Gaia is put into its „retirement“

orbit. The probe is scheduled to be shut down completely at the end

of March 2025.

Science fans still have the opportunity to say goodbye to Gaia

with a last look at the space probe: During the upcoming technology

tests, Gaia‘s orientation will be changed. This will make the

probe temporarily brighter in the night sky and facilitate observation

through small telescopes.

Despite the approaching end, Gaia remains a milestone in the

exploration of the universe. The planned publication of further data

sets in 2026 and 2030 could once again expand our knowledge of

the universe.

Das Fraunhofer-Institut für Angewandte Optik und Feinmechanik IOF

D 07745 Jena

Microstructure of the Gaia transmission grating.

The grating is part of the “Radial Velocity Spectrometer”

on board the probe.

© Fraunhofer IOF


page 4/41

Coperion Announces Expansion

of Switzerland Test Center to

Enhance Capabilities

Coperion K-Tron located in Switzerland, a

global leader in feeding and pneumatic conveying

technology solutions, is excited to

announce the expansion of its state-of-theart

test center at its facility in Niederlenz.

This strategic move is designed to enhance

the company‘s capabilities, particularly for

tests involving materials that require containment.

The expansion will allow Coperion

to conduct more comprehensive and

diverse testing, providing customers with a

broader range of solutions for their specific

material handling needs. The new facility

will be equipped with the latest technology

and equipment, ensuring the highest standards

of safety and efficiency. The addition

to the Test Center will feature advanced

containment systems for handling all types

of materials, including an airlock system

with filtration, ensuring the safety of both

the testing process and the staff as well as

the environment. This will allow the company

to better serve industries such as battery,

chemicals, pharmaceuticals, and food processing,

where containment and hygienic

requirements can be a critical concern.

„Coperion is committed to delivering the

best possible solutions to our customers,“

said Marco Hadrys, Test Center Manager in

Niederlenz. „The expansion of our Test Center

is a significant step towards achieving

this goal. It will enable us to conduct more

extensive tests, particularly with materials

that require containment, and provide our

customers with even more reliable and ef-

Breaking ground on the much-anticipated

expansion. From left to right: Keith Melton,

Sales Manager Battery Industry, Marco Hadrys,

Test Center Manager, Manfred Bossart, Facility

Manager, Michael Reinhard, General Manager.

(Photo: Coperion K-Tron (Switzerland) LLC)

ficient solutions.“

The Test Center also provides opportunities to the Research and Development teams

to test prototypes when developing new products or improving existing equipment

and processes. (Photo: Coperion K-Tron (Switzerland) LLC)

Customer trials and R&D to be conducted

at newly expanded test center

The purpose of customer tests is twofold:

to confirm the handling of customer-specific

bulk materials and to pinpoint and

resolve any potential issues before the customer

commits to a purchase. The goal of

each test is to offer the customer the most

suitable feeding and/or conveying equipment

ensuring they feel confident in their

decision for the most reliable technology

available. In addition, the Test Center also

provides opportunities to the Research and

Development teams to test prototypes when

developing new products or improving existing

equipment and processes. Coperion

performs an average of 150 tests per year

in Niederlenz, testing a broad range of raw

materials such as plastic pellets, granulates,

powders, flakes or liquids as well as end products

such as bottle caps, chocolate chips or

breakfast cereal, from all industries (including

plastics, battery, chemicals, food and

pharmaceuticals).

The new addition is expected to be

completed by April 2025, and the company

looks forward to welcoming customers to

the new facilities. “Coperion is confident

that this investment will further strengthen

our position as a leading provider of material

handling solutions and contribute to our

ongoing growth and success” said Michael

Reinhard, General Manager at Coperion K-

Tron (Switzerland).

The Test Center expansion in Niederlenz

represents a significant enhancement

to the global network of world class Coperion

Test Centers, reflecting the company‘s

commitment to innovation and customer

support. This state-of-the-art facility not

only increases the capacity for testing and

development but also incorporates advanced

technologies that enable more efficient

and precise material processing evaluations.

By providing a dedicated space for customers

to conduct trials and optimize their

processes, the Niederlenz expansion reinforces

Coperion‘s role as a leader in the industry.

It fosters collaboration and knowledge

sharing, ensuring that clients can leverage

the latest advancements in equipment

and technology to meet their specific needs.

Test results are incorporated into a global

database covering over 15,000 materials.

With almost 125 years of experience in

the manufacture of industrial equipment,

the Coperion K-Tron site in Niederlenz is

today a leading global supplier of process

equipment. Innovative know-how is the

cornerstone to reliable feeding systems and

pneumatic conveying systems as well as

comprehensive material handling systems.

Coperion K-Tron (Switzerland) LLC

CH 5702 Niederlenz


page 5/41

ZETA PL will cater to both pharma and non-pharma industries with a

broad spectrum of services. (Copyright: ZETA)

Main office in Gdansk (ul. Norwida 4;

80-280 Gdańsk). (Copyright: ZETA)

ZETA Expands to Poland with New Subsidiary

New subsidiary for ZETA in Poland

ZETA, leading international end-to-end solution provider

for the pharmaceutical and biotech industry, is excited to

announce the opening of its new subsidiary, ZETA PL Sp. z

o.o., in Gdansk, Poland. This expansion marks a significant

step in ZETA’s growth strategy within the European Union,

tapping into Poland’s thriving economy, particularly in the

pharma, biotech, and diverse non-pharma sectors such as

food and cosmetics.

ZETA PL will cater to both pharma and non-pharma industries with

a broad spectrum of services, including facility and process engineering

services, EPCM services (engineering, procurement, construction

management), process equipment, product and components

sales, optimization services (e.g., bioreactor characterization, process

simulation, process automation), and sustainability services

(e.g., decarbonization, energy efficiency measures).

ZETA, leading international end-to-end solution provider for the pharmaceutical

and biotech industry. (Copyright: ZETA)

Leveraging Expertise and Strong Local Partnerships

ZETA already has a strong presence in the Polish market and is starting

with an experienced team. They bring extensive expertise in oral

solid dosage (OSD), sterile and non-sterile production, high potent/

cytotoxic, and cell culture, mammalian production, mAb, and biological

APIs. The team disciplines include project management, building

supply technology, process facility with clean media, architects,

cleanroom, HVAC (heating, ventilation, air conditioning), black media,

electrical, BMS (building management system), and EMS (environmental

monitoring system).

A Growing Pharmaceutical Market

„Poland‘s thriving pharmaceutical market presents a promising opportunity

for ZETA,“ say Hans Eder and Clemens Borkenstein, managing

directors of ZETA PL, in unison. The country boasts the largest

pharmaceutical market in Central and Eastern Europe and the

fifth-largest in the European Union by value.

„The expansion to Poland is a strategic move for ZETA, aiming

to leverage the country’s growing economy and significant market

potential. With a dedicated and experienced team, ZETA PL is set

to deliver innovative solutions and continue its legacy of successful

projects in Europe,“ concludes Andreas Marchler, managing director

of the ZETA group.

ZETA GmbH

AT 8501 Lieboch/Graz


page 6/41

Production optimization through

new ASYS technologies

The ASYS Group has successfully supported Preh GmbH in

the modernization of its production facilities. By replacing

machines and integrating modern technologies, Preh, a

global automotive supplier, was able to significantly increase

the efficiency and sustainability of its production.

As part of the collaboration, ASYS supplied five INSIGNUM 4000

laser marking systems, an EKRA SERIO 4000 printing solution and

various VEGO transport and overhead modules to Bad Neustadt.

The machines from the ASYS portfolio complement the new double-track

lines, which were specially designed for the requirements

of electromobility at Preh GmbH.

As in the manufacturing industry in general, Preh is constantly

faced with the challenge of optimizing production processes, reducing

costs and integrating new technologies. The Bavaria-based

company has successfully mastered these challenges by replacing

older machines with modern and innovative solutions. Preh is once

again relying on the powerful solutions of the ASYS Group and integrating

the latest INSIGNUM laser marking systems and SERIO

printers - durable and high-quality machines with simple operation,

flexible customization options and smooth integration into existing

systems.

Technical innovation and strategic partnership

A key project for Preh was the implementation of new double-track

lines that were specially optimized for products in the e-mobility

segment. These lines minimize the need for retooling and allow

seamless integration into the production landscape through digital

connections.

Quote from Dirk Petzold, Process Engineer

Electronics Assembly at Preh:

„We have been very satisfied with the machines from ASYS for many

years. We are impressed by the durability and flexibility of the systems.

The wide range of products also suits us very well. If a requirement

is not covered by the already extensive standard range, ASYS

can offer customized solutions from special machine construction.

There is actually almost nothing that does not exist.“

ASYS Prozess- und Reinraumtechnik GmbH

Lerchenbergstraße 31

D 89160 Dornstadt

Telefon: +49 7348 98560

Telefax: +49 7348 985691

eMail: info@asys-reinraum.de

Internet: http://www.asys-reinraum.de


page 7/41

Published in Science: Researchers Show How Machine Learning Can Greatly Accelerate

the Search for New Semiconductor Molecules for Perovskite Solar Cells

Finding Better Photovoltaic

Materials Faster with AI

Perovskite solar cells are a flexible and sustainable alternative to conventional

silicon-based solar cells. Researchers at the Karlsruhe Institute of Technology

(KIT) are part of an international team that was able to find – within only a few

weeks – new organic molecules that increase the efficiency of perovskite solar

cells. The team used a clever combination of artificial intelligence (AI) and automated

high-throughput synthesis. Their strategy can also be applied to other

areas of materials research, such as the search for new battery materials. The researchers

report their findings in Science (DOI: 10.1126/science.ads0901).

One in a million: Artificial intelligence helps scientists in their search for new materials to be used in

high-efficiency solar cells. (Photo: Kurt Fuchs/HI ERN)

In order to find out which of a million different

molecules would conduct positive

charges and make perovskite solar cells particularly

efficient, one would need to synthesize

and test all of them – or do as the researchers

headed by Tenure-track Professor

Pascal Friederich, who specializes in the applications

of AI in materials science at KIT’s

Institute of Nanotechnology, and Professor

Christoph Brabec from the Helmholtz Institute

Erlangen-Nürnberg (HI ERN). “With

only 150 targeted experiments, we were

able to achieve a breakthrough that would

otherwise have required hundreds of thousands

of tests. The workflow we have developed

will open up new ways to quickly and

economically discover high-performance

materials for a wide range of applications,”

Brabec said. With one of the discovered materials,

they increased the efficiency of a reference

solar cell by approximately two percentage

points to 26.2 percent. “Our success

shows that enormous amounts of time and

resources can be saved by applying skillful

strategies for the discovery of new energy

materials,” Friedrich said.

The starting point at HI ERN was a

database with structural formulae for approximately

one million virtual molecules

that could be synthesized from commercially

available substances. From these virtual

molecules, 13,000 were selected at random.

The KIT researchers used established quantum

mechanical methods to determine their

energy levels, polarity, geometry and other

properties.

Training AI with Data from Just 101 Molecules

From the 13,000 molecules, the scientists

chose 101 with the greatest differences in

their properties, synthesized them with

robotic systems at HI ERN, used them to

produce otherwise identical solar cells, and

then measured the efficiency of the solar

cells. “Being able to produce truly comparable

samples thanks to our highly automated

synthesis platform, and thus being able

to determine reliable efficiency values, was

crucial to our strategy’s success,” said Brabec,

who headed the work at HI ERN.

The researchers at KIT used the achieved

efficiencies and the properties of the

associated molecules to train an AI model,

which suggested 48 other molecules to

synthesize. Its suggestions were based on

two criteria: high expected efficiency and

unforeseeable properties. “When the machine

learning model is uncertain about the

predicted efficiency, it’s worthwhile to synthesize

the molecule and take a closer look

at it,” Friederich said, explaining the second

criterion. “It might surprise us with a high

efficiency level.”

Using the molecules suggested by the

AI, it was indeed possible to build solar

cells with above-average efficiency, including

some exceeding the capabilities of the

most advanced materials currently used.

“We can’t be sure we’ve really found the

best one of a million molecules, but we’re

certainly close to the optimum,” Friederich

said.

AI Versus Chemical Intuition

Since the researchers used an AI that indi-

Original publication

Jianchang Wu, Luca Torresi, ManMan Hu, Patrick Reiser, Jiyun Zhang, Juan S. Rocha-Ortiz, Luyao Wang, Zhiqiang Xie, Kaicheng Zhang, Byung-wook Park,

Anastasia Barabash, Yicheng Zhao, Junsheng Luo, Yunuo Wang, Larry Lüer, Lin-Long Deng, Jens A. Hauch, Dirk M. Guldi, M. Eugenia Pérez-Ojeda, Sang

Il Seok, Pascal Friederich, Christoph J. Brabec: Inverse design of molecular hole-transporting semiconductors tailored for perovskite solar cells.

Science, 2024. DOI 10.1126/science.ads0901.


page 8/41

cates which of the virtual molecules’ properties

its suggestions were based on, they

were able to gain some insight into the molecules

it suggested. For example, they determined

that the AI-suggestions are based

in part on the presence of certain chemical

groups, such as amines, that chemists had

previously neglected.

Brabec and Friederich believe that their

strategy holds promise for other applications

in materials science or can be extended

to the optimization of entire components.

The findings, which are the result

of research conducted in collaboration

with scientists from FAU Erlangen-

Nürnberg, South Korea’s Ulsan National

Institute of Science, and China’s Xiamen

University and University of Electronic

Science and Technology, were

published recently in the prestigious

journal Science. (ffr)

Karlsruher Institut für Technologie

D 76131 Karlsruhe

Custom robotic workstation automates company’s broad portfolio

of biology assays for academia, biotech, and pharma.

Merck Partners with Opentrons

Labworks, Inc., supporting Lab

of the Future

– Custom robotic workstation automates company’s broad portfolio of biology assays for academia, biotech, and pharma

– Meets growing need for autonomous tools that boost throughput and reproducibility

– Provides customers with verified and automated workflows

Merck, a leading science and technology company, and Opentrons

Labworks, Inc., a leader in lab automation and accessible robotics,

announced a multi-year agreement to automate assay kits on a custom

Opentrons Flex® workstation.

Scientists and engineers will collaborate to develop and verify

platform workflows utilizing Merck’s broad offering of automationenabled

assays. Together, the custom workstation and automationenabled

assays will deliver increased consistency and higher throughput

by reducing manual processing and repetitive tasks with a userfriendly

robotic system.

“Our customers are prioritizing tools and technologies that improve

reproducibility and productivity, allowing them to focus on

more complex tasks that take their science further, faster,” said Jean-

Charles Wirth, Head of Science & Lab Solutions for the Life Science

business of Merck. “Our partnership with Opentrons reinforces our

focus to automate and digitalize the lab - supporting scientists at all

stages with tools that can increase efficiency, safety, and success rates

of delivering new potential therapeutics.”

Customers can place orders for workstations and assay kits from

Merck starting mid-2025. Applications will include broad workflows

across protein sample preparation, molecular, cell, and other biochemical

and chemistry workflows launching throughout the length of

the agreement.

“Part of our commitment to making lab automation as accessible

as possible is finding partners who share a similar vision,” said

Jonathan Brennan-Badal, CEO of Opentrons. “Merck Life Science is

a proven leader in terms of the breadth and quality of products they

offer for pharmaceutical development and manufacturing, and we’re

excited to combine that with our ability to provide world-class automation,

service and support.”

By combining the automation expertise and service excellence

of Opentrons with the powerful R&D, supply chain, and quality systems

of Merck we will deliver reliable products streamlining research

from sample prep to analysis for immunodetection, protein research,

enzyme technology, genome editing, omics research, pharmaceutical

development, service and testing and cell culture.

This adds to Merck’s existing Biology innovations to increase

Life Science lab productivity, like the Millicell® DCI Digital Cell

Imager that allows for accelerated cell culture analysis with an intuitive

interface while also adding to the company’s commitment to

provide next-generation biology solutions such as their recent acquisition

of HUB Organoids Holding B.V.

Merck KGaA

D 64293 Darmstadt

www.reinraum.de | www.cleanroom-online.com

NEWSLETTER | Edition EN 03-2025

page 9/41

The key criteria for stable and damage-free cleaning of the stents include a homogeneous sound

field in addition to an optimally tuned ultrasound frequency and power. (Image source: Weber

Ultrasonics)

Very high cleanliness requirements are placed

on delicate implants such as stents, and

cleaning must be very gentle, which can be

ensured by ultrasonic cleaning. (Image source:

Weber Ultrasonics)

Ultrasound for intermediate and final

cleaning of medical devices

The power of sound

waves for stable cleanliness

Ultrasonic cleaning is the standard

procedure for medical technology

products such as instruments, implants

or other devices with very high

cleanliness requirements. (Image

source: Weber Ultrasonics)

The manufacture of medical technology products such as

implants, instruments and devices is subject to very strict

requirements - including for parts cleaning. Ultrasound is

an indispensable process here. It ensures that the required

cleanliness is achieved in a stable, efficient and sustainable

manner during both intermediate and final cleaning.

Ultrasound and medical technology - this combination is initially

associated with diagnostic imaging. However, ultrasound can do

much more in this area. Sound with frequencies above the human

hearing range has established itself as an economical and sustainable

standard process for wet-chemical cleaning applications in the

manufacture and reprocessing of medical technology products such

as instruments, implants and other devices. And it can be used for

components made of a wide variety of materials such as stainless

steel, titanium, cobalt-chrome alloys, ceramics and plastic.

Optimally adaptable to the task

For products with an open-pored sponge structure, with

combined porous and polished surfaces and components with

very fine capillaries, ultrasound can be combined with

pressure cycling. (Image source: Weber Ultrasonics)

In cooperation with cleaning system manufacturers and users, Weber

Ultrasonics develops custom-designed generators and transducer

systems as rod, plate and immersible transducers with different

frequencies for the very different cleaning tasks in medical technology.

This includes single-frequency solutions as well as dual- and

multi-frequency ultrasonic systems in a frequency range from 25

to 132 kHz. They enable the construction of space-saving cleaning

systems that are individually tailored to the workpieces and cleaning

requirements. The development of vacuum-proof single, dual and


page 10/41

multi-frequency immersible transducers also opens up the use of

ultrasonic cleaning in full-vacuum cleaning systems. For high-purity

applications, where particularly high demands are placed on component

cleanliness and cleaning equipment, immersible transducers

and plate transducers are available in a suitable design. With a surface

roughness of < 0.35 µm, they meet the requirements of hygiene

class 4 in accordance with DIN 11866.

Cleaning stents reliably and without damage

Heinz Schade, Managing Director of the company of the same name,

also relies on the wide range of highly effective ultrasonic components.

Founded in 1999 and based in Reutlingen, the company develops

and produces machines for balloon and catheter production

as well as stent processing, which are sold worldwide. In addition,

there is software that is optimally adapted to the various machines

and, among other things, enables the seamless documentation and

traceability of processes required in medical technology. This helps

to ensure that the strict requirements of the MDR with regard to process

and product safety and quality management are met.

One focus of the system portfolio is on manufacturing steps for

stent production that follow laser cutting, such as electropolishing,

heat treatment, pickling and ultrasonic cleaning. The company has

been manufacturing the tanks for the cleaning systems in-house

for around 20 years. This allows them to be adapted to the various

products and the specific requirements of the respective customer.

„With our own production facilities, we were looking for a supplier

for the ultrasonic components. In Weber Ultrasonics, we found a

partner that has impressed us to this day with its expert advice and

uncomplicated cooperation,“ reports Heinz Schade.

To ensure the quality and safety of the products, the stents are

usually cleaned between the various processes. Final cleaning is

then carried out before packaging, usually in a clean room. „Increasingly

stringent surface cleanliness requirements have to be met. At

the same time, it must be ensured that the sensitive stents are not

damaged during cleaning,“ says the Managing Director, specifying

the requirements. The key parameters for this are the frequency of

the ultrasound and the power in watts per liter of bath volume. In

addition, a homogeneous sound field must be generated in the bath

to ensure a consistently stable result. „The ultrasonic solutions from

Weber Ultrasonics are ideal for these tasks. The power can be set

very precisely by controlling the generator and the sound output is

constant and reliable. We have had no problems with the ultrasonic

systems so far,“ adds Heinz Schade.

The tanks of the cleaning systems are adapted to

the products to be cleaned and equipped with

ultrasound. (Picture source: Heinz Schade)

Particulate and film-chemical impurities are removed

Ultrasound develops its cleaning effect in a liquid bath through the

physical effect of cavitation: the electrical signals generated by an

ultrasound generator are transmitted into the liquid through oscillating

elements. The sound pressure is characterized by an alternation

of negative and positive pressure. In the negative pressure phases,

microscopically small cavities are formed, which collapse (implode)

in the subsequent positive pressure phase. This creates shock waves

with considerable energy, which „blast off“ particulate and film-chemical

contaminants. At the same time, microcurrents are created in

the liquid, which flush away detached or dissolved contaminants.

These effects make it possible to remove contaminants not only

from the surface, but also from complex geometries, cavities, holes

and structures.

For critical surfaces in combination with pressure cycling processes

Stents are used to reopen vessels or keep them open. Very high process

and product safety and quality management requirements must be met

during their production in accordance with the MDR. (Image source:

Freepik, peakanucha)

For components such as additively manufactured implants with an

open-pored sponge structure or combined porous and polished surfaces

as well as components with very fine capillaries, ultrasound

can be combined with pressure cycling processes. In these vacuum

flood cleaning processes, alternating negative and positive pressure

and cavitation effects are generated by regularly repeating pressure

changes. This allows cleaning and rinsing media to reach areas that

would otherwise only be reached to a limited extent or not at all.

Weber Ultrasonics AG

D 76307 Karlsbad-Ittersbach


page 11/41

Tech Lunch with Kai-Uwe Hölzel

Energy Efficiency in Pharmacy Cleanrooms

Wearing a sweatshirt, jeans and white sneakers: Kai-Uwe Hölzel arrives at the Tech Lunch dressed casually. When speaking,

he is engaged and highly focused. Accompanying his concise technical input is a Flammbrot from the wood-fired oven topped

with tomato, mozzarella, pepperoni, and spicy salami.

Mr. Hölzel, everyone is talking about energy efficiency.

How does that apply to pharmacies?

Sustainability and energy efficiency are definitely important topics

for pharmacies. Carbon footprint and energy costs are becoming

increasingly important, especially if you have your own production

facility with a cleanroom.

What sort of amounts are we talking about here?

It depends on many factors. Annual energy costs for a cleanroom

can easily reach six figures. Any savings will significantly improve

profitability.

Can pharmacy cleanrooms be energy efficient?

There‘s no question that cleanrooms require a lot of energy for

process-related reasons. However, with the right measures, energy

consumption can be reduced by up to 30%. So, yes, cleanrooms in

pharmacies can be operated energy-efficiently.

How can the efficiency of pharmacy cleanrooms be improved?

It is crucial to analyze all aspects in detail and derive the appropriate

measures. This starts with the product: non-toxic products, such

as parenteral nutrition, have different requirements for a cleanroom

compared to toxic products, like cytostatics. This opens up a number

of possibilities for layout design and energy efficiency. For toxic

products, 100% outside air must be used, leaving little room for

optimization.

What does 100% outside air mean for efficiency?

Quite simply, cleanroom air must undergo extensive conditioning.

First, it is significantly cooled for dehumidification, then heated to

the target temperature. This is a very energy-intensive process. For

non-toxic products, recirculation allows the conditioned air to be

reused, maximizing the efficiency of the energy used. However, this

is only partially possible for air contaminated with pollutants. Suitable

decoupled circuit-based systems for this purpose have a significantly

lower efficiency than systems with recirculation operation.

How else can efficiency in cleanrooms be optimized?

The layout is a critical factor. Designing the cleanroom to meet specific

needs - from workstations to corridors and airlocks - can help

reduce energy costs over the long term. Unfortunately, cleanroom

technology is often over-engineered out of fear of taking risks. With

experience and technical expertise, the air exchange rate can be

optimized, while taking into account the heat load of the equipment

used in the cleanroom, without compromising safety or violating

complex regulatory requirements.

What legal requirements need to be considered?

It depends: For standard pharmacies, the Pharmacy Operating

Regulations (Apothekenbetriebsordnung) apply. Pharmacies and

hospital pharmacies operating as manufacturing facilities fall under

Section 13 of the Medicinal Products Act (Arzneimittelgesetz) and,

for example, require a monitoring system. It is also important to

have a good understanding of the regulator. Even after the revision

of Annex 1 / EU-GMP Guidelines, there are regional differences

in interpretation. Not understanding this can lead to costly and

energy-intensive mistakes that, in the worst case, may prevent the

facility‘s approval.

Are there other adjustments to consider?

Cleanrooms are big energy consumers. You can significantly

reduce your energy consumption with the right planning.

Yes. Non-toxic areas should mostly operate with recirculated air.

The proportion of outside air should be based on the minimum requirements

of the processes involved. The reason for this is that the


page 12/41

Engineer Kai-Uwe Hölzel

After completing his degree in Energy Systems Engineering

and a Master‘s in Mechanical Engineering and Energy Technology,

Kai-Uwe Hölzel has been with Weiss Klimatechnik since

2017. As Head of Technical Sales and Planning and an active

volleyball player, he is a committed and ambitious team player.

recirculated air does not have to undergo extensive conditioning.

Also, a defined maintenance mode during weekends or vacation

periods can reduce air volume by 30–40%, saving energy. Energy

efficiency can also be fine-tuned by using special filters with lower

air resistance for the same filtration performance. Despite their

purchase price, they often pay for themselves within a few years.

Under the right conditions, high-pressure spray humidifiers can

also reduce energy consumption. These must be suitable for the

application and the water quality must be sufficiently good to avoid

any risk from contamination.

What else can pharmacists do?

Our cleanrooms also run on photovoltaic power, which allows the

pharmacists to optimize their energy consumption, such as electricity,

heating and cooling. If they use a heat pump, that‘s also great,

because we can work easily with the lower flow temperatures. They

can save a lot here compared to gas or oil. It is best to involve us as

early as possible in the planning of a new building or renovation

project, so that we can plan everything from the outset in a way

that is energy efficient. By the way, external consultants sometimes

recommend things that are energy-efficient but technically and

legally impossible for pharmacies to implement. We understand

pharmacies, products, processes and the legal environment. That is

always helpful.

How do you assess the development of energy efficiency

in cleanrooms?

Little or nothing can be changed in the production process itself.

If a process requires a cleanroom, it will remain energy-intensive.

Rising energy costs and growing environmental awareness will

increasingly enable us to exploit opportunities to improve energy

efficiency. And we have a lot to offer in this area.

Thank you for the interview, Mr. Hölzel, and bon appétit.

Weiss Klimatechnik GmbH

D 35447 Reiskirchen

Alles für Ihren Reinraum

aus einer Hand

Bekleidung & Handschuhe

Tücher & Swaps

Reinigungsgeräte- & mittel

Dispenser

Partikelmessgeräte

Staubbindematten

HANS J. MICHAEL GmbH, Hart 11, 71554 Weissach im Tal

hjm-reinraum.de | Tel. 07191/9105-0 | office@hjm-reinraum.de


page 13/41

Fig. 1: Visualisation of the H.E.S.S. telescope array

capturing the showers of particles produced by

high-energy cosmic electrons and positrons, as

well as gamma rays. © MPIK/H.E.S.S. Collaboration

H.E.S.S. collaboration detects the most energetic

cosmic-ray electrons and positrons ever observed

Electrons from space

Fig 2: Artist‘s impression of a pulsar with its powerful magnetic field rotating around it. The

clouds of charged particles moving along the field lines emit gamma rays that are focused

by the magnetic fields, rather like the beams of light from a lighthouse. In these magnetic

fields, pairs of positrons and electrons are created and accelerated, making pulsars

potential sources of high-energy cosmic electrons and positrons. © NASA/Goddard

Space Flight Center Conceptual Image Lab

Scientists from the H.E.S.S. collaboration including a consortium of German universities, the Max-Planck-Institut für

Kernphysik and the CNRS in France have recently identified electrons and positrons with the highest energies ever recorded

on Earth. They provide evidence of cosmic processes emitting colossal amounts of energy, the origins of which are as

yet unknown. These findings are due to be published on November 25 in the journal Physical Review Letters.

The universe is full of extreme environments,

from the coldest temperatures to

sources of the utmost energies possible. Extreme

objects such as supernova remnants,

pulsars or active galactic nuclei can produce

charged particles and gamma-ray light,

whose energies exceed those achievable in

thermal processes such as nuclear fusion in

stars by many orders of magnitude.

While the emitted gamma light travels

undisturbed through space, the charged

particles - or cosmic rays - are deflected by

the omnipresent magnetic fields in the universe

and reach the Earth isotropically from

all directions. Furthermore, the charged

particles loose parts of their energy along

the way, interacting with light and magnetic

fields. These losses are particularly severe

for the most energetic electrons and positrons

with energies above Tera-electronvolt

(1 TeV = 1012 electronvolt), called cosmic-ray

electrons (CRe). Their presence on Earth is

therefore a clear indicator for the existence

of powerful nearby cosmic particle accelerators,

even if they cannot be used to trace

their point of origin in space.

Fig. 3: Energy spectrum of the CRe. The

red circles indicate the CRe candidates

measured by H.E.S.S.. The dark red band

corresponds to the broken power law fitted

to the data, where the width of the band

corresponds to the statistical errors of the

measurements. The light blue band indicates

the estimated range of the actual CRe flux,

taking into account CRn contamination as well

as statistical and systematic errors.

However, the detection of multi-Teraelectronvolt

electrons and positrons is quite

difficult: space instruments with a detection

area of about one square metre cannot capture

enough of the increasingly rare particles.

Ground-based instruments can detect

the particle cascades initiated when the

cosmic particles hit the Earth’s atmosphere

but face the challenge of identifying electron-

or positron-initiated cascades among

the much more frequent cascades generated

by impacting heavier cosmic-ray nuclei.

In 2008, researchers had first succeeded in

identifying CRe’s in the data collected by

the ground-based H.E.S.S. Cherenkov telescopes.

The H.E.S.S. observatory located in Namibia

uses five large imaging atmospheric

Cherenkov telescopes to record the faint

Cherenkov light produced by highly charged

particles and photons perpetrating our

planet’s atmosphere and producing a particle

cascade in their wake (fig. 1). While the

primary aim of the H.E.S.S. observatory is to

detect and select gamma rays, and to image

their sources, the data can also be exploited


page 14/41

The H.E.S.S. Observatory

High-energy gamma rays can only be observed from the ground with a trick.

When a gamma ray enters the atmosphere, it collides with atoms and molecules

and generates new particles that race on towards the ground like an

avalanche. These particles emit flashes lasting only a few billionths of a second

(Cherenkov radiation), which can be observed with specially equipped large

telescopes on the ground. High-energy gamma astronomy therefore uses the

atmosphere like a giant fluorescent screen. The H.E.S.S. observatory, located in

the Khomas Highlands of Namibia at an altitude of 1835m, officially went into

operation in 2002. It consists of an array of five telescopes. Four telescopes

with mirror diameters of 12 m are located at the corners of a square, with a

further 28 m telescope in the center. This makes it possible to detect cosmic

gamma radiation in the range of a few tens of Giga-electronvolts (GeV, 109

electronvolts) to a few tens of Tera-electronvolts (TeV, 1012 electronvolts).

For comparison: visible light particles have energies of two to three electron

volts. H.E.S.S. is currently the only instrument that observes the southern sky in

high-energy gamma light and is also the largest and most sensitive telescope

system of its kind.

to search for cosmic-ray electrons.

A new analysis presented by scientists from the H.E.S.S. collaboration was now

able to obtain new insights into the origin of these particles. In their work the astrophysicists

reassessed the huge data set collected during a decade by four of the

H.E.S.S. telescopes and applied novel and strongent selection algorithms to identify

CRe’s with an unprecedented low background contamination. This resulted in an

unequalled high statistics data set for the analysis of the cosmic electrons. In particular,

the researchers from the collaboration were able to obtain CRe data in the

highest energy regimes up to 40 TeV (Tera-electronvolt) for the first time ever.

“We could observe that the energy spectrum of the CRe exhibits a smooth decline

with increasing energy, the spectrum steepening markedly at approximately at

1 Tera-electronvolt. Both above and below this break, the spectrum follows a power

law in energy, without exhibiting any additional features, as were predicted by many

models for CRe acceleration”, remarks Mathieu de Naurois from the Laboratoire Leprince-Ringuet,

E´cole Polytechnique, CNRS, one of the lead authors of the study.

The researchers found, however, that the transition from a shallow to a steep

decline at about 1 Tera-electronvolt is surprisingly sharp.

“This is an important result, as we can conclude that the measured CRe most

likely originate from very few sources in the vicinity of our own solar system, up to a

maximum of a few 1000 light years away, a very small distance compared to the size

of our Galaxy. Emissions originating from many sources at different distances would

wash out this signal considerably”, explains Kathrin Egberts from the University of

Potsdam, co-author of the study. “We were able to put severe constrains on the origin

of these cosmic electrons with our detailed analysis for the first time”.

Prof. Werner Hofmann from the Max-Planck-Institut für Kernphysik in Heidelberg

explains the implications of the new analysis for astrophysical research: “The

very low fluxes at higher energies place severe constraints on the possibilities of space-based

missions to compete with this measurement. Thereby, our measurement

does not only provide data in a crucial and previously unexplored energy range, impacting

our understanding of the local neighbourhood, but it is also likely to remain

a benchmark for the coming years”, he concludes.

Bibliography:

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

H.E.S.S. Collaboration. Physical Review Letters, November 25, 2024.

DOI: 10.1103/PhysRevLett.133.221001

arXiv: http://arxiv.org/abs/2411.08189

Max-Planck-Institut für Kernphysik

D 69117 Heidelberg

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www.dastex.com


page 15/41

Due to the high number of samples in a large buffer reservoir and the

possibility of easy buffer exchange, the Xpress Dialysis Box ensures high

dialysis efficiency with minimal effort. (Source: Andreas Balg)

Even very small sample volumes can be dialyzed easily. Various

cartridge models enable low-loss dialysis of sample volumes

ranging from 10 µl to 1000 µl. (Source: Andreas Balg)

SBS Standard and Optimized Box Design for Use in Liquid Handling Systems

Turbo for Protein and RNA Purification:

Unique Cartridge Design Enables

Accelerated Dialysis of Up to 96

Samples Simultaneously

Life sciences, biomedicine, and pharmaceuticals: Protein purification after cell lysis or other substance separations for further

in-vitro studies are standard tasks in everyday laboratory work. Dialysis using a dialysis tube has proven indispensable

for this purpose. This method allows the gentle separation of low-molecular-weight substances such as salts or nucleic

acids from high-molecular-weight sample components like proteins. However, for automated sample processing, dialysis

using a dialysis tube is unsuitable. Even with small sample volumes or large numbers of samples, where personnel costs and

process duration are decisive cost factors, dialysis using a dialysis tube proves inefficient and time-consuming. The Xpress

Dialysis Box (XDB) from Scienova now provides a solution. Individual samples or up to 96 samples can be processed

in parallel in the included Xpress Dialyzers in cartridge format, significantly reducing workload. The dialysis cartridges‘

unique, patented design ensures reliable, low-loss sample extraction, even for the smallest sample volumes of just a few

microliters. The large buffer reservoir of the XDB and the optimized volume-to-surface ratio of the Xpress Dialyzers with

short diffusion paths ensure a significantly shortened dialysis duration. The Xpress Dialysis Box provides an efficient and

time-saving solution for protein purification in the laboratory, delivering reliable results while reducing costs and effort.

Both the Xpress Dialysis Box and the Xpress Dialyzers are

designed to be compatible with the SBS standard, making them

suitable for automation, especially for large, regularly recurring

sample numbers. (Source: Andreas Balg)

To purify proteins without loss of quality, dialysis is commonly used

as a separation method to remove unwanted salts or buffers as a

preparatory step before further protein processing. „Although dialysis

as a technique is relatively old, it remains one of the gentlest

methods for maintaining protein activity in samples,“ says Dr. Stefan

Kreusch, Managing Director of scienova GmbH.

However, this gentle method is time-consuming, inflexible, and

labor-intensive in its traditional form. The classical dialysis method

using a dialysis tube proves cumbersome and uneconomical, especially

for small sample volumes ranging from 10 to 1000 μl and large

sample numbers.

To make laboratory dialysis more efficient and improve handling

for small and variable sample volumes, scienova GmbH from Jena

has specialized in optimizing dialysis. The company offers Xpress

Dialyzers in cartridge format for small sample volumes. These dialysis

cartridges enable fast and loss-free sample processing and are

arranged in a microtiter plate grid (SBS standard). Unlike the conventional

dialysis tube method, they are also suitable for automated


page 16/41

The Xpress Dialyzers feature specially designed sample openings.

The precise fit of the pipette tips ensures low-loss filling and extraction

of samples, achieving a recovery rate of up to 99%.

(Source: Christian Häcker)

The ability to pipette 8 samples in parallel makes the dialysis

cartridges highly efficient. (Source: Christian Häcker)

sample processing. Scienova‘s latest development, the Xpress Dialysis

Box, combines efficient individual cartridges with a large 750 ml

buffer reservoir. Compared to conventional dialysis in tubes, which

can take several hours, using the XDB significantly reduces dialysis

time and workload. The information box with an example illustrates

the benefits of this innovation.

Patented Design Prevents Sample Loss and Membrane Fouling

The scienova Xpress Dialyzers are single-use cartridges with a highquality

membrane of a defined cut-off. The cut-off, also known as

Molecular Weight Cut-Off (MWCO), specifies which molecular

size or molecular weight limit a membrane allows to pass or to retain.

Larger molecules above a certain molecular weight cannot pass

through the membrane, while smaller molecules can diffuse through,

separating them from the larger molecules. The required cut-off size

of a membrane can vary depending on the application, which is why

scienova offers different cut-offs between 2 kDa and 140 kDa.

The patented cartridge geometry achieves a high membrane surface-to-volume

ratio, increasing dialysis efficiency. The larger surface

allows faster diffusion of small molecules through the membrane.

Additionally, the risk of clogging (membrane fouling) is minimized

by the vertically aligned membrane, preventing sample components

from settling, which could lead to sample loss or reduced dialysis

speed. Various cartridge sizes are available for sample volumes from

10 μl to 1000 μl. The Xpress Dialyzer Family includes models such as

MD100, MD300, ED300, and MD1000, named after their respective

dialysis capacity.

The Xpress Dialyzers are placed in an insert, allowing an entire

sample set of up to 96 samples to be positioned into the XDB

buffer reservoir in a single step. After dialysis is complete, the insert

can be easily removed, and the buffer quickly replaced. Buffer

exchange can be performed manually or using a peristaltic pump,

as the Xpress Dialysis Box is equipped with convenient Luer-Lock

connections. The dialysis cartridges are compatible with common

laboratory equipment and can be operated with standard pipettes

or pipetting robots. A multichannel pipette allows simultaneous

loading or extraction of all eight samples in a column. The specially

designed openings of the Xpress Dialyzers enable precise and

low-loss pipetting using standard pipette tips, even for the smallest

sample volumes.

Optimized Handling Enables Broad Application Spectrum

The scienova Xpress Dialyzers are designed for use with various

pipetting and laboratory automation systems, as they are compatible

with the microtiter plate standard (SBS). Due to this versatility,

they are suitable for applications such as high-throughput screening

(HTS), scouting experiments, routine analyses in medical laboratories,

and RNA oligonucleotide purification. In vaccine development,

they can be used to produce antigen variants. „Since many proteins

are highly sensitive to environmental factors and their production is

complex, we wanted to provide laboratory personnel with an attractive

tool that enables simple, safe, gentle, and effective work,“ explains

Dr. Kreusch. In addition to speed, reproducibility without quality loss

is also a focus of further development. In the future, sensors can be

connected via corresponding interfaces to measure parameters such

as temperature and conductivity in the buffer reservoir. This allows

real-time monitoring of the dialysis process, enabling easy evaluation

of dialysis results, comprehensive data storage, analysis, logging,

and detailed documentation.

„With this modern and comprehensive dialysis technology, laboratories

not only preserve their resources but also achieve an entirely

new level of cost-effectiveness compared to conventional separation

methods. Small sample volumes, high sample throughput, and

safe handling—no traditional dialysis tube can compete,“ concludes

Dr. Kreusch.

_______________

XDBTM, Xpress DialyzerTM , and scienovaTM are trademarks of scienova

GmbH, Spitzweidenweg 30, Jena, Deutschland.


page 17/41

Representation of Dialysis Efficiency and Calculation of Time Effort Based

on an Example

dialyzer, measured via optical density at 280

nm in a spectrometer. All data are based on

three independent trials and are presented

with mean values and standard deviations.

Total Duration: The entire process takes

approximately 51 minutes.

1. Pipetting the Samples: Using an 8-channel

pipette to fill the dialysis cartridges

with 96 samples, filling the buffer reservoir,

and placing the samples into the

dialysis box. Duration: approx. 2 minutes.

2. Dialysis Time: Dialysis until equilibrium is

reached. Duration: approx. 45 minutes.

3. Sample Extraction: Removing the cartridge

insert and extracting the samples

using an 8-channel pipette. Duration:

approx. 2 minutes.

Result:

In the XDB, 9.6 ml of a potassium chloride-bovine serum albumin solution (KCl-BSA solution)

with a concentration of 2 M KCl and 2 mg/ml BSA was dialyzed against 750 ml of

distilled water. The dialysis was performed in 12 MD100 cartridges (cut-off 6-8 kDa), with

each cartridge containing 8 × 100 µl KCl-BSA solution on a magnetic stirrer, supplemented

by a conductivity sensor in the buffer reservoir. The blue line represents the measured conductivity

(EC) of the diffused KCl, while the dashed red line shows the calculated percentage

of remaining KCl in the dialyzers. The red dots indicate the percentage of BSA in the

The initial concentration of 2 M KCl in the

samples is reduced to approximately 25 mM.

By repeating the dialysis through buffer exchange,

the KCl concentration in the samples

decreases to 0.33 mM.

scienova GmbH

D 07743 Jena

The Group has achieved 78 out of 100 points in the EcoVadis sustainability rating

Endress+Hauser maintains Gold status

This combined score puts Endress+Hauser among the top 5 percent of the approximately 150,000 rated companies. The

EcoVadis assessment is based on several criteria relating to the environment, labor, human rights and ethics. For Endress+Hauser,

the rating is a key metric for gauging its own sustainability performance. It is also a valuable tool for the

Group’s customers and suppliers, giving them transparency around whether Endress+Hauser is a reliable partner and meets

international standards.

“Our aim is to help our customers be sustainable and efficient in their

production, so we must set an example with our own business and

production processes. Gold status demonstrates our commitment to

being a trusted advisor and that we are moving forward successfully,”

commented Dr Peter Selders, CEO of the Endress+Hauser Group.

Higher score despite more challenging requirements

Endress+Hauser has improved its sustainability performance in

essentially all areas since last year, increasing its combined score

from 71 to 78. EcoVadis rated the Group particularly highly on its

performance against environmental and labor standards. “We are

very pleased with this result, especially considering that EcoVadis

has tightened up its requirements over the same period,” said Julia

Schempp, the head of the Endress+Hauser Group’s Corporate Sustainability

Office.

All measures disclosed in EcoVadis audits must be supported by

detailed evidence of implementation, otherwise they are not taken

into account. Here, Endress+Hauser benefits from a structured approach

in that it maintains robust, comprehensive documentation

of its measures and KPIs. This includes clear guidelines on matters

such as work safety and the management of hazardous materials.

Group sets ambitious targets

The Endress+Hauser Group’s sustainability efforts are also reflected

in its emission reduction targets. The Group has committed to reaching

net-zero greenhouse gas emissions by 2050 and thus supports

the efforts of the Paris Agreement to limit global warming to 1.5°C

above pre-industrial levels.

Peter Selders: “Sustainability is very important to me personally.

We need to protect the climate and the environment to ensure livability

for future generations. When they grow up, our children should

be able to enjoy the same quality of life as we do now. As a company,

we can make an important contribution to shaping change for the

better while still being successful financially.”

Endress+Hauser AG CH 4153 Reinach BL 1


page 18/41

Latest UV/Vis Software Module for Highly Automated Laboratories and Contract Labs

Efficiency Boost for Laboratories:

Analytik Jena Integrates SPECORD

PLUS Devices into LMS Systems

Analytik Jena, a Germany-based manufacturer

of analytical instruments, now offers laboratories

with a high degree of automation and a large

number of samples per day the ability to centralize

and digitize their measurement processes in

the UV/Vis technology range. The latest update

of the UV/Vis device software ASpect UV enables

the control of Analytik Jena’s SPECORD PLUS

devices via an external Laboratory Management

System (LMS).

With the new SOAP interface module of the ASpect

UV software, methods can be created, measurements

performed, and results reported back to the system directly

from the LMS. The associated analytical device

SPECORD PLUS is thus fully integrated into the system

landscape. This allows users to work in their existing

LMS without having to learn and use separate device

software. Users can start measurements flexibly from

anywhere. The software module tracks all content and

processes, thereby avoiding manual data copying errors

between different systems.

In addition, the current update of the ASpect UV

software provides extended functions for kinetic measurements

and significantly more comprehensive, formula-based

data evaluation. With the new 21 CFR Part

11 compliance module, ASpect UV offers regulated industries,

such as the pharmaceutical, food, or beverage

industries, a further advantage: integration with the customer’s

user management via Active Directory eliminates

the need to create separate user accounts and passwords

for ASpect UV.

The SPECORD PLUS Devices of Analytik Jena

The dual-beam spectrophotometer SPECORD PLUS

is a classic Analytik Jena device in the field of UV/Vis

technology, which, with the help of the basic software

ASpect UV and numerous specific tools, can perform

a wide range of individual analyses in the fields of chemistry,

pharmaceuticals, medicine, food safety, environmental

analysis, life sciences, and more. The modular

design of the Windows-based software enables intuitive

and precise work, tailored to every level of experience

and requirement. It serves the complete control, monitoring,

and documentation of all processes of the spectrophotometer,

including its accessories. Compliance

with 21 CFR Part 11 and Pharmacopoeia Europaea 11 can

optionally be ensured.

Analytik Jena GmbH+Co. KG

D 07745 Jena


page 19/41

A technical engineer in the cleanroom at Infineon Technologies in Villach, Austria, holds a 200 mm silicon carbide wafer.

Infineon reaches next milestone

on 200 mm silicon carbide (SiC) roadmap:

Product-roll out to customers starts

– Infineon releases first silicon carbide products to customers based on advanced 200 mm SiC wafer

manufacturing technology

– The products, manufactured in Villach, Austria, provide first-class SiC power technology for high-voltage applications

– 200 mm SiC production will strengthen Infineon‘s technological leadership across the spectrum

of all power semiconductor materials

Infineon Technologies AG (FSE: IFX / OTCQX: IFNNY) has made

significant progress on its 200 mm silicon carbide (SiC) roadmap.

The company will already release the first products based on the

advanced 200 mm SiC technology to customers in Q1 2025. The

products, manufactured in Villach, Austria, provide first-class SiC

power technology for high-voltage applications, including renewable

energies, trains, and electric vehicles. Additionally, the transition

of Infineon‘s manufacturing site in Kulim, Malaysia, from

150-millimeter wafers to the larger and more efficient 200-millimeter

diameter wafers is fully on track. The newly built Module 3 is

poised to commence high-volume production aligned with market

demand.

“The implementation of our SiC production is progressing as

planned and we are proud of the first product releases to customers,”

said Dr. Rutger Wijburg, Chief Operations Officer of Infineon. “By

ramping up SiC production in Villach and Kulim in phases, we are

improving cost-efficiency and continuing to ensure product quality.

At the same time, we are making sure our manufacturing capacities

can meet the demand for SiC-based power semiconductors.”

SiC semiconductors have revolutionized high-power applications

by switching electricity even more efficiently, demonstrating

high reliability and robustness under extreme conditions, and by

making even smaller designs possible. Infineon’s SiC products let

customers develop energy-efficient solutions for electric vehicles,

fast charging stations and trains as well as renewable energy systems

and AI data centers. The release to customers of the first SiC products

based on the 200-millimeter wafer technology marks a substantial

step forward in Infineon’s SiC roadmap, with a strong focus

on providing customers with a comprehensive portfolio of high-performance

power semiconductors that promote green energy and

contribute to CO 2 reduction.

As “Infineon One Virtual Fab” for highly innovative wide-bandgap

(WBG) technologies, Infineon’s production sites in Villach and

Kulim share technologies and processes which allow for fast ramping

and smooth and highly efficient operations in SiC and gallium

nitride (GaN) manufacturing. The 200-millimeter SiC manufacturing

activities now add to Infineon’s strong track record of delivering

industry-leading semiconductor technology and power system solutions

and strengthen the company’s technology leadership across

the entire spectrum of power semiconductors, in silicon as well as in

SiC and GaN.

Infineon Technologies AG

D 85579 Neubiberg


page 20/41

HIPS researchers are opening up new avenues for the treatment

of multi-resistant pathogens

Targeted intervention in the

metabolism of bacteria

Antibiotics are a double-edged sword – they should be as toxic as possible to pathogenic bacteria while being harmless to

the cells of the human body. An international research team led by the Helmholtz Institute for Pharmaceutical Research

Saarland (HIPS) has now developed drug candidates that achieve precisely that. The new molecules target a metabolic pathway

that only occurs in bacterial cells, thus sparing human cells. The team published its results in the journal Angewandte

Chemie International Edition.

3D model of the interaction

between the enzyme IspD

from Pseudomonas

aeruginosa and one of the

developed inhibitors.

Bacterial cells differ fundamentally

in their structure from animal and

human cells. For example, bacteria

have a rigid cell wall, whereas human

cells are surrounded only by a simple

membrane. If a pharmaceutical agent

targets cell wall construction, only bacterial cells

are affected. This principle is an important basis

for the development of antibiotics, since these

should only act on the disease-causing bacteria,

but not humans themselves. In their search for

new active ingredients, a research team led by

HIPS department head Prof. Anna Hirsch has

now taken a closer look at a less obvious difference between bacteria

and humans that has not yet been pharmaceutically exploited:

the so-called methylerythritol phosphate pathway, or MEP pathway

for short. The HIPS is a site of the Helmholtz Centre for Infection

Research (HZI) in collaboration with Saarland University.

The MEP pathway is an essential part of the energy metabolism

of several bacteria, including the hospital germ Pseudomonas aeruginosa.

If the MEP pathway in bacteria is blocked, for example by a

drug, they can no longer produce a number of vital natural products

and subsequently die. Human cells do not have the MEP pathway

and would therefore not be affected by a respective drug. In the

search for such an active substance, Hirsch‘s team together with

the group of Franck Borel (University of Grenoble) as part of a consortium

funded by the European Union has analyzed the individual

steps of the MEP in great detail. Their focus was on the enzyme IspD,

which is responsible for the third step in the MEP Pathway. The researchers

were able to solve the crystal structure of IspD from P. aeruginosa

for the first time, thus gaining deep insights into its structural

composition. With the help of the information obtained, the team

was able to investigate how a specific chemical fragment binds to the

enzyme. This so-called complex structure has enabled the design of

optimized derivatives that make even better use of the binding pocket

and thus bind more strongly

to the enzyme.

“The fragments we synthesized

bind excellently to their target

protein IspD, and their other

pharmaceutical properties also

offer a promising basis for the development

of new active ingredients,” says Eleonora Diamanti,

project manager of the consortium and

now assistant professor at University of Bologna.

Hirsch, who also holds a professorship in

medicinal chemistry at Saarland University,

says: “What makes the newly developed molecules

so special is that they target IspD, a protein that is not addressed

by any drug currently on the market. This is the only way to

ensure that a potential new antibiotic will also be effective against

pathogens that have already become resistant to most conventional

drugs.”

Hirsch and her team are currently working on the further development

of the new molecules. To this end, they are planning to

collaborate closely with the planned excellence cluster nextAID³, in

which unexplored targets such as IspD will also play an important

role. The next steps include efficacy studies in bacteria and the optimization

of efficacy and other pharmaceutical parameters.

Original Publication

Daan Willocx, Lucia D‘Auria, Danica Walsh, Hugo Scherer, Alaa Alhayek,

Mostafa M. Hamed, Franck Borel, Eleonora Diamanti, Anna

K. H. Hirsch. Fragment Discovery by X-Ray Crystallographic Screening

Targeting the CTP Binding Site of Pseudomonas Aeruginosa

IspD. Angewandte Chemie (2025) DOI: 10.1002/anie.202414615

Helmholtz-Zentrum für Infektionsforschung GmbH

D 38124 Braunschweig


page 21/41

Needle-Trap Secu: The innovative needle protection label with

an integrated sealing function and irreversible first-opening

indication has been recognized with the World Label Award 2024

in the “Innovation” category. © Schreiner Group

Awarded the World Label Award, Needle-Trap Secu sets

new benchmarks in terms of combining safety, efficiency,

and sustainability. © Schreiner Group

Distinguished Recognition for Needle-Trap Secu

Schreiner Group Wins World

Label Award for “Innovation”

The innovative needle protection label Needle-Trap Secu

from the Schreiner MediPharm business unit has been recognized

with the prestigious World Label Award 2024 in

the “Innovation” category. This special honor not only validates

the innovative prowess of Schreiner Group’s products

but also confirms the company’s commitment to developing

pioneering solutions for the healthcare industry.

The World Label Award that has been presented since 1996 is one of

the most important international competitions of the label industry.

It is organized by L9, a global alliance of the major label associations.

A high-caliber judging panel made up of industry experts evaluated

the entries submitted in a total of 24 categories. The awards ceremony

took place in Chicago at the end of 2024, one day before Labelexpo

America opened.

Innovative Product Design with Sustainable Added Value

The award-winning Needle-Trap Secu product sets new benchmarks

in terms of combining safety, efficiency, and sustainability.

The world’s only needle protection system featuring a needle trap

directly integrated in the label offers healthcare staff safe and easy

handling of prefilled syringes. At the same time, the innovative

construction, thanks to its compact design, reduced plastic material

content, and integrated sealing function saves space and resources.

Needle-Trap Secu’s special sealing tab offers irreversible first-opening

indication ensuring the integrity of the syringe up until its

use—which eliminates the need for an additional blister pack. These

features not only enhance the safety and security of the product but

also make it extremely sustainable and cost-efficient.

Exceptional Innovative Prowess

Roland Schreiner, President and CEO of Schreiner Group, is delighted

about this outstanding recognition. “Having won the World

Label Award in the Innovation category documents our company’s

exceptional innovative prowess and untiring commitment of our

employees. With Needle-Trap Secu we showed once again how high

tech and sustainability can be perfectly combined with each other.

Successes like these reinforce our resolve to continue developing

forward-thinking solutions with passion and precision,” he said.

Schreiner MediPharm

D 85764 Oberschleißheim


page 22/41

Innovative minds present pioneering

ideas for the plastics and rubber industry

Start-up Zone at K/Credit: Andreas Wiese

After its successful debut at the previous K the Start-up Zone will also form an integral part of the trade fair again in 2025 –

this time located in the direct proximity of the Science Campus. Celebrating a premiere will be the Start-up Pitch as part of

the Special Plastics Shape the Future.

Start-up Zone

By organising the Start-up Zone K in Düsseldorf, the world-leading

trade fair for the plastics and rubber industry, intends to once again

offer young companies a dedicated stage from 8 to 15 October 2025.

After all, it is especially start-up companies that play a decisive role

for the plastics and rubber industry since they introduce innovations

and fresh ideas into an industry increasingly faced with such

challenges as sustainability, efficiency and digitalisation. Especially

start-ups are characterised by great pioneering spirit, risk affinity

and high flexibility.

At K 2025 the Start-up Zone will be situated in Hall 7.0 and, hence, in

the immediate vicinity of the Science Campus. At the Science Campus

universities (of applied sciences) and institutes will present the

latest results of their plastics research. Both K Specials ideally complement

each other. The immediate vicinity of the Start-up Zone and

Science Campus will make Hall 7.0 a unique science and innovation

hub.

Young companies still have the chance to register for the Start-up

Zone thereby leveraging the opportunity of presenting their developments

at the world’s most relevant industry trade fair and making

valuable international business contacts. A special participation

package has been prepared for them minimising the obstacles

and organisational expenses associated with participating in such a

large trade fair.

Participation criteria:

– The company is younger than 10 years

– It employs less than 100 employees

– Annual sales do not exceed € 10 million

The registration form can be downloaded at: www.k-online.com/

Start-up Zone . The contact person for the Start-up Zone is Katharina

Kolissnyk, Kolissnyk@messe-duesseldorf.de .

Startup-Pitch Towards Zero

In line with the Start-up Zone the official Special Plastics Shape the

Future, organised by Plastics Europe, will also offer the newcomers

in the industry a dedicated forum at K for the first time – the Startup-

Pitch Towards Zero. Here, start-ups whose innovations and technologies,

solutions or new business models for a circular economy with

plastics, for the decarbonisation of the plastics industry or the reduction

of so-called Scope-3 emissions, are given the opportunity

to showcase their pioneering technology projects and network with

partners worldwide.

The Startup-Pitch Towards Zero will take place at K 2025 on

Monday, 13 October, as part of the Special Plastics Shape the Future

in Hall 6 of the Düsseldorf Exhibition Centre. The deadline for applications

is 1 March 2025: TOWARDS ZERO - Startup Pitch at K 2025.

Messe Düsseldorf GmbH

D 40001 Düsseldorf


page 23/41

Research transfer of quantum technologies to industry

Fraunhofer IAF Launches Virtual

Application Lab for Quantum Sensing

To promote the use of quantum sensors in industry, Fraunhofer IAF has developed

a virtual application laboratory for quantum sensing. This innovative information

platform provides comprehensive technical knowledge about quantum

magnetometers, applications, and measurement scenarios. It also allows interested

parties from industry and research to interactively perform sample measurements

and assess the potential of this groundbreaking technology for their needs.

Access is available through the website www.quantensensing.de/en.

Quantum sensors enable extremely precise

measurements and offer enormous potential,

especially in materials testing, the semiconductor

industry, and biomedicine. “With

our virtual application lab for quantum

sensing, we support industry and science

in exploring the possibilities of quantum

sensors and evaluating solutions for specific

application scenarios,” explains Deborah

Mohrmann, project manager and business

developer at the Fraunhofer Institute for

Applied Solid State Physics IAF. “This platform

makes our technologies and expertise

available to a broad audience and promotes

the transfer of our research results into industrial

innovations.”

Explore and test quantum sensors

The individual measurement results show

that quantum magnetometers can make

magnetic field distributions visible at the

nanoscale. © Fraunhofer IAF

plication lab are interactive measurements

that showcase measurement scenarios from

the fields of materials testing, micro- and

nanoelectronics, and biomedicine. For each

sector, users can run through several measurement

scenarios, retrieve individual results,

or get an overall evaluation. Whether

it’s nanoparticles in biological tissue, crack

formations in metallic samples, or magnetic

fields in microelectronic circuits—quantum

The measurement examples range from biomedical, micro- and nanoelectronics,

and materials testing. © Fraunhofer IAF

The virtual application lab provides an overview

of the quantum sensors used at Fraunhofer

IAF and their possible applications. It

features three quantum magnetometers and

offers detailed technical information and

explanations of the different measurement

principles of the devices. The core of the apmagnetometers

can visualize magnetic field

distributions at the smallest level and provide

relevant information about the samples.

Easy access to expert knowledge

With the virtual application lab for quantum

sensing, companies and institutions benefit

from easy access to the latest expertise on

how quantum sensors work and where they

can be used, as well as the ability to assess

the benefits and application potential of the

devices for their specific needs. The accompanying

website provides extensive information

on quantum sensing and its potential

applications. Professional contacts from

research and technology transfer are available

to share their knowledge and provide

advice.

The content and technical concept of

the virtual application lab for quantum sensing

were developed by Fraunhofer IAF. The

technical implementation was carried out

by the Service Center Training and Knowledge

Transfer of the Fraunhofer Institute for

Solar Energy Systems ISE. The initiative was

funded by the State of Baden-Württemberg,

the Fraunhofer-Gesellschaft and Fraunhofer

IAF’s own resources.

On-site testing

In addition, Fraunhofer IAF has established

a physical application laboratory for quantum

sensing at the institute’s location in

Freiburg, Germany. Interested companies,

SMEs, and start-ups can conduct magnetic

field measurements with their own samples

on site and test the use of quantum magnetometers

for their applications. Fraunhofer

IAF uses quantum magnetometers based on

nitrogen-vacancy centers in diamond. These

single atomic systems act as highly sensitive

magnetic field sensors, can operate at

room temperature and in background fields,

and enable extremely high spatial resolution.

These properties make quantum magnetometers

ideal for industrial applications.

Fraunhofer-Institut für Angewandte

Festkörperphysik IAF

D 79108 Freiburg


page 24/41

How botox enters our cells

Researchers at the Center for Life Sciences at the Paul Scherrer Institute PSI have for the first time identified structural

changes in the botulinum neurotoxin, botox for short, that are believed to be crucial for its uptake into nerve cells. This

could mean that the paralysing effect of this potent neurotoxin could be used more selectively and efficiently in the future,

for example in pain therapy. The study was published in the journal Nature Communications.

Botulinum toxin A1, better known under

the brand name Botox, is not only a popular

cosmetic agent, but also a highly effective

bacterial neurotoxin that – when carefully

dosed – can be used as a drug. It blocks

the transmission of signals from nerves to

muscles: This can relax muscles under the

skin, which in cosmetics is used to smooth

facial features. It can also alleviate conditions

that are caused by cramping muscles or

faulty signals from nerves, such as spasticity,

bladder weakness, or misalignment of the

eyes. However, if the dose is too high, the

use of Botox can be fatal due to paralysis of

the respiratory muscles. This can happen as

a result of bacterial meat poisoning and is

called botulism.

To make the most effective use of botulinum

toxin as a drug, to precisely control its

action, and to expand the range of possible

applications of the toxin, researchers want

to better understand how the toxin enters

nerve cells to exert its effect. Until now, little

was known about this. “This is mainly because

we had no structural data on what the

toxin looks like in its full length form when

binding to its nerve cell‘s receptor,” says

Richard A. Kammerer of the PSI Center for

Life Sciences. So far there had only been

studies on the structure of individual domains

of the toxin – that is, specific parts of

its complex molecular structure – and on the

structure of such domains in complex with

the receptor or one of its domains.

Observations at minus 160 degrees

To change this, Kammerer and his team joined

forces with Volodymyr M. Korkhov‘s

research group. This group, which works in

the same laboratory at PSI, specialises in

determining the structure of proteins, particularly

membrane proteins. In the joint

study, the researchers observed samples of

the neurotoxin alone and with the receptor

in a so-called cryo-electron microscope.

In cryo-electron microscopy, samples are

shock-frozen at minus 160 degrees without

ice crystals forming. “This way, the sample

Mahir Dzambegovic / Volodymyr M. Korkhov (left) and Richard Kammerer of the Center for Life

Sciences at PSI have made important advances towards understanding how botulinum neurotoxin,

botox for short, enters our nerve cells. © Paul Scherrer Institute PSI/Mahir Dzambegovic

retains its structure permanently and we

can study it at our leisure,” explains Basavraj

Khanppnavar, first author of the study. “This

gives us particularly precise insights into the

molecular architecture,” adds his colleague

and fellow first author Oneda Leka.

In this way, the researchers determined

both the structure of the entire toxin on

its own and the structure of the molecular

complex of the toxin with the receptor. They

did this at low and neutral pH values, such as

those found in the so-called synaptic vesicle.

After the toxin docks onto the receptor,

this vesicle-like cell organelle takes up the

toxin and transports it into the interior of

the cell.

The compact form can interact better

As it turns out, the subsequent drop in the

pH value of the maturing vesicle is crucial

for the transport of the toxin across the vesicle

membrane into the cytosol – this is the

part of the cell where most biochemical reactions

take place, and also where the toxin

exerts its effect. “At a low pH value of around

5.5, the toxin bends from its usual elongated,

open form into a spherical, compact form,”

Volodymyr Korkhov reports. This brings the

crucial domains of the protein close to the

vesicle membrane. “In the elongated form

observed at neutral pH value of around 7,

however, they are too far away from the

membrane for interaction.» In that case, the

so-called translocation of the toxin from the

interior of the vesicle into the cytosol of the

cell cannot take place.

Of all the research groups working on

this topic, the PSI team is the first in the

world to provide structural data on the full

length toxin in complex with the receptor

before translocation. “This gives us a much

more realistic idea of the crucial mechanisms

of translocation,” says Kammerer.

Further studies are needed, however, before

translocation will be fully resolved. “But with

the study now published, we have already

taken an important step that could help to

use botulinum neurotoxin much more effectively

in the future, for example in the

treatment of pain.”

Paul Scherrer Institut

CH 5232 Villigen PSI


page 25/41

High-volume spring parts © UpNano

Microfluidic nozzles in four sizes © UpNano

UpNano starts a new chapter in high precision two-photon polymerization (2PP) 3D printing

with the launch of their NanoPro service. A newly developed printer model acts as the

powerful engine that runs the new service, offering serial production of microp

NanoPro unveiled:

NanoPro Revolutionizes 2PP 3D Printing with

Industrial-Scale Micropart Production Service

UpNano GmbH (Vienna, Austria) today unveiled the world’s first 2-photon polymerization (2PP) 3D printer built for industrial

mass production of microparts – the NanoPro VT. Presented at the international trade fair, Formnext, in Frankfurt,

Germany, the new high-performance printer is the engine that powers the company’s new NanoPro service, offering highvolume

production of microparts for industrial manufacturing processes – something that hasn’t been achievable until

now. The machine uses extremely efficient and cost-effective mechanisms, finally allowing 2PP 3D printing of polymeric

microparts at a mass-production scale. Offered as a fully integrated service, the use of the NanoPro VT marks the beginning

of a new era for industry.

Due to its extraordinary precision, rapid and flexible prototyping

using 2PP 3D printers has revolutionized the development processes

in many industries thus far. However, relatively long production

times and available materials have limited its use to prototyping and

batch production. For many years, the focus of innovation has been

to speed up the production process while increasing the resolution

range and use of materials. No one has excelled at this more than

Austria’s UpNano GmbH, who five years ago launched the highest

performing 2PP 3D printer on the market – the NanoOne, employed

by industry and high-end research institutions around the world.

Building on this acclaimed success, their R&D department continued

to optimize the performance of the technology further, culminating

in the NanoPro VT.

Bernhard Küenburg, CEO of UpNano at the launch event: “With

the development of the NanoPro VT, UpNano is now in the position

to offer the first fully integrated 2PP based service for industrial

microparts. With over 20 years of experience in 2PP technology,

our team is available to collaborate closely with customers to deliver

tailored solutions from design via prototyping to serial production

including delivery worldwide.”


page 26/41

NanoPro VT cleanroom © UpNano

From Rapid Prototyping to Rapid Production

With the launch of the NanoPro service, UpNano offers an excellent

solution for unmet needs in industrial microfabrication. The highest

resolution and tolerance combined with unmatched throughput facilitates

the scalable production of innovative and complex designs.

In fact, the technical capabilities of the newly developed NanoPro

VT are impressive: The firepower of the patented printing system

enables a performance of 32 Megavoxels (million volume pixels) per

second compared to projection-based technologies (DLP) at only

two Megavoxels in about 3-10 seconds. Depending on the configuration,

this translates into a throughput of several thousand mm3 per

hour, many factors higher than any other 2PP technology currently

on the market.

“This outstanding performance”, explains Peter Gruber, CTO of

UpNano, “makes it possible to print a million identical parts, or a million

parts with individual modifications. In addition, the resolution

of the printer allows structures and tolerances below 100 nm. The

ability to print the entire surface of 200x200mm substrates is also

unique. An automatic lens changer increases flexibility and enables

optimized production cycles with the extremely robust NanoPro VT,

which operates under ISO 5 cleanroom conditions,is temperaturestable

and vibration-isolated.”

Scalable Solution for Growing Challenges

The NanoPro service enters the market at a time when the miniaturization

of production parts has often reached the limits of existing

technologies such as DLP, µSLA, SLA, MIM or FDM. Designs are

getting increasingly intricate and complex while production tolerances

are getting more stringent. In addition, the global economy is

driving fierce competition, making economy of scale through highvolume

production even more necessary than ever. NanoPro offers

scalable solutions that can’t be found elsewhere on the market. On

top of its technical competences, UpNano is ISO 9001 and 14001 certified,

ensuring that any service offered fulfils the latest industry and

environmental standards.

Performance Printing as a Service

Bernhard Küenburg sums up: “In essence, the service we now offer

reduces costs for customers by eliminating the need for clean room

facilities, post-processing equipment, metrology, and inspection. On

top of that, NanoPro also stands for continuous development. While

we already offer state-of-the-art production technologies today,

the platform will continue to set new standards in the future. The

NanoPro service means dedicated partnership, guaranteed excellence,

and continuous innovation.” Owners of the desktop version of

UpNano’s 2PP 3D-printers, the NanoOne series, can perform the initial

steps of designing and prototyping in-house, with support from

UpNano experts, before seamlessly transferring their designs to serial

production at UpNano via NanoPro. UpNano recently launched

a new model in the NanoOne series, the NanoOne green, which is

now the improved printing platform to prototype parts for NanoPro

due to its green 515 nm wavelength laser which is the same used in

the NanoPro VT. This new wavelength offers over 30% higher precision

compared to a 780 nm laser wavelength and the ability to work

with a broader range of standard and transparent materials. With the

introduction of NanoPro as a new fully integrated service offering,

UpNano expands its state-of-the-art solutions within the manufacturing

industry. In addition to NanoPro, UpNano continues to offer

the NanoOne series of printers, resins for various applications, and

an advanced software package. All of which are already widely in use

in industry and research around the world.

UpNano GmbH

AT 1030 Wien

VT production 3D printer © UpNano


page 27/41

German premiere for European Robotics Forum:

ERF in Stuttgart in March 2025

For the first time, the flagship event for the European robotics community

“European Robotics Forum” will take place in Germany. © Fraunhofer IPA

Bringing the European robotics community together: The opening of the ERF 2024 in Rimini.

© euRobotics/Visual Outcasts

Over 1,300 attendees from European research, industry, and politics, with more

than 60 sponsors and an extensive program on robotics and artificial intelligence

(AI): The top-class European Robotics Forum (ERF) of euRobotics, the European

Robotics Association, will take place in Stuttgart‘s Liederhalle from March 25-27,

2025. The Fraunhofer-Gesellschaft with the Fraunhofer institutes IPA and IAO,

the University of Stuttgart and Cyber Valley are cooperation partners. The state

capital Stuttgart and other partners also support ERF.

partner and an event agency, are responsible

for organizing the event. The President

of euRobotics Bernd Liepert says: “ERF has

been part of our story since euRobotics was

founded in 2010, even two years before the

euRobotics association was formally founded.

Since then it has become part of the

glue that binds research and industry together

so well. As the robotics association for

the whole European continent we always

take an international perspective.”

Werner Kraus, Head of Fraunhofer IPA‘s

Automation and Robotics research division,

is the general chair of the event. He is

particularly pleased about bringing ERF to

Stuttgart in the “Year of Robotics”, as it has

already been proclaimed in the press, and

to use it as a platform and catalyst for new

innovations: “In the context of demographic

change, robotics is seen as the technology

for securing prosperity. With its strong robotics

ecosystem of users and suppliers of

AI robotics solutions, Baden-Württemberg

is helping to shape this future. More than

ever, new ideas are needed, as the ERF will

provide. I am very grateful for the wide-ranging

support, because it is only with this that

such a large event is possible.”

For the first time in its 15 years, ERF is coming

to Germany. In spring 2025, the European

robotics community will meet at its

flagship event in the Liederhalle, located in

the heart of Stuttgart. ERF is the most important

European event for robotics and AI

and this year‘s theme is “Boosting the Synergies

between Robotics and AI for a stronger

Europe”. The aim is to bring together

research and industry, present the current

state of robotics and AI on a large stage and

help shape future technological developments.

Bind research and industry together

“The increasing integration of robotics with

artificial intelligence, cognitive systems,

and machine learning holds tremendous

potential for our economy and society. It is

crucial for Germany and Europe to not only

use these technologies but also to develop

them. This is the only way we can actively

set standards and secure a leading position

in international competition,” says Prof.

Holger Hanselka, President of the Fraunhofer-Gesellschaft.

“The Fraunhofer-Gesellschaft

is making an important contribution

by advancing these technologies while also

supporting companies and SMEs in fully

exploiting the potential of service and industrial

robotics. I am delighted that we are

supporting the European Robotics Forum as

a research partner.”

euRobotics, the European Robotics Association,

in collaboration with the Fraunhofer

Institute for Manufacturing Engineering

and Automation IPA as its scientific

One event, many formats

ERF features a diverse range of event formats

and is therefore unique in the European

robotics community. Keynotes, lectures,

and workshops make up a large part

of the very diverse program. For example,

attendees can select between more than

50 workshops with topics like application

trends in industrial and service robotics, generative

AI in robot programming and control,

regulatory AI Act or humanoid robots.

In addition, individuals and companies can

apply for several euRobotics awards, which

will be presented during ERF. These include

the Tech Transfer Award for outstanding

success in transferring research results into

business applications, the Renaud Champion

Entrepreneurship Award, which is given


page 28/41

An exhibition and interactive opportunities bring a wide range of robotic

applications to life. © euRobotics/Photo: Jon Agirre Ibarbia

to the most promising robotic start-up idea,

and the Georges Giralt PhD Award for the

best doctoral thesis in the field of robotics.

An exhibition of robot and AI-based applications,

presented in the style of a trade

fair, complements the program. Networking

and professional exchange also play a major

role – which include two evening events and

site visits to the regional robotic ecosystem.

Scientific Track and Public Engagement

The “Scientific Track”, i.e. the scientific

part of the program organized by the University

of Stuttgart and Fraunhofer IPA, is

being held for the second time. Its premiere

at 2024 ERF in Rimini was very successful.

The Fraunhofer Institute for Industrial Engineering

IAO will contribute with program

items on the topic of “Future of Work”. ERF

will also provide a platform for major national

and international initiatives such as the

Robotics Institute Germany, RoX – Digital

Ecosystem for AI-based Robotics, and the

ROS Industrial Consortium for open-source

software.

For the first time, free program items in

the weeks leading up to and during the ERF

are planned, which, in the spirit of “public

engagement”, shall address interested parties

from all areas of society, to inform and

start an exchange about robotics and AI. As

a cooperation partner, Cyber Valley, Europe‘s

center for excellence in AI and modern

robotics, is contributing this part of the program

to the event.

Great appeal for European robotics

The event will have a major impact on European

robotics. The fact that it is being held

in Germany for the first time is a perfect fit,

as it is the country with the highest number

of euRobotics members and the highest robot

density in Europe, with 429 robots per

10,000 employees. This puts Germany in

fourth place worldwide, with South Korea

in first place with 1012 robots, according to

an annual survey by the International Federation

of Robotics. AI-based robotics is also

an important strategic cornerstone of German

and European economic and science

policy to tackle social challenges such as

demographic change and labour shortages.

Important impetus for this will also come

from the conference “AI-based Robotics

2025” (KIRO), which will be integrated into

ERF and is carried out by the Federal Ministry

of Economic Affairs (BMWK) and of

Education and Research (BMBF).

Many well-known guests

In this context, numerous well-known

guests lend ERF additional significance.

The current Federal Minister of Economic

Affairs, Robert Habeck, is announced

for the official opening on March 25, 2025.

Professor Holger Hanselka, President of the

Fraunhofer-Gesellschaft, will also be part

of the official opening of ERF. Contributions

by Baden-Württemberg‘s Minister for

Economic Affairs, Labour and Tourism, Nicole

Hoffmeister-Kraut, and by Lucilla Sioli,

Director for AI and Digital Industry at the

European Commission, are further official

items on the program. The local Ministry of

Economic Affairs, Labour and Tourism is a

co-organizer of the ERF 2025. Finally, the

state capital Stuttgart, and the Stuttgart Region

Economic Development Corporation

are also supporting the ERF. Stuttgart’s Lord

Visits such as a tour to Fraunhofer IPA show

the strengths of the regional robotics ecosystem.

© Fraunhofer IPA/Foto: Rainer Bez

Mayor Frank Nopper will be giving a welcome

speech at the pre reception that will be

hosted by the City of Stuttgart.

Press conference and panel discussion

Following the opening on March 25, a press

conference and panel discussion about Europe’s

status and possibilities with respect

to robotics and AI technologies is planned,

which is aimed in particular at media representatives.

The General Chair of the event,

Werner Kraus from Fraunhofer IPA, as well

as the Co-Chairs Matthias Peissner (Fraunhofer

IAO), Professor Alexander Verl and

Professor Marco Huber (both from the University

of Stuttgart) and Rebecca C. Reisch

(Managing Director of Cyber Valley GmbH)

will also take part. From euRobotics, Bernd

Liepert will join. Journalists from the daily,

weekly and trade press can register free of

charge for ERF.

Further information for interested parties,

media representatives, potential sponsors,

and exhibitors, as well as all program

and registration details: www.erf2025.eu

Fraunhofer-Institut für Produktionstechnik

und Automatisierung IPA

Nobelstraße 12

D 70569 Stuttgart

Telefon: +49 711 970 1667

eMail: joerg-dieter.walz@ipa.fraunhofer.de

Internet: http://www.ipa.fraunhofer.de


page 29/41

automatica 2025 on course

for growth despite weak economy

– A third of ca. 500 exhibitors are celebrating their premiere at automatica:

more hall space already occupied than in 2023

– Additional focus: Healthtech

– Top-level supporting program

Preparations for the next automatica—the leading trade fair for smart automation and robotics—are in full swing. From June

24 to 27, 2025, automatica will bring industry and research together in six exhibition halls and offer an unparalleled overview

of the latest topics and innovations. In June, the focus will be on technical solutions and exchanging ideas on digitalization

and AI, sustainable production, and the future of work. “automatica is thus addressing highly relevant issues that the

industry is intensively concerned with. The high demand we are experiencing proves that we have our finger on the pulse

with these topics, “ says Exhibition Director Anja Schneider. Six months before the start of the trade fair, more space has

already been booked than in 2023. Around 500 exhibitors from over 30 countries have currently registered, a third of whom

are exhibiting at the trade fair for the first time.

Great response from leading companies in robotics

and automation

All the key robotics and automation companies will come together in

the automatica halls. Alongside the well-known international industry

giants that have been using automatica as their leading trade fair

for many years, newcomers such as ATI Industrial Automation (Novanta),

Delta Electronics, Device Insight, ESTUN AUTOMATION,

HANWHA ROBOTICS, HARTING, HD HYUNDAI ROBOTICS,

Reis Robotics, RK Rose+Krieger, SAP and Shenyang SIASUN Robot

& Automation will also be presenting themselves at the upcoming

event. It is worth noting that Chinese exhibitors have a much stronger

presence at the trade fair than ever before. “automatica brings

together all the main companies—whether from Europe, Asia or

America—and thus represents the entire international market, “ says

Anja Schneider.

Healthtech focus at automatica

For the first time, automatica is also offering special solutions covering

all aspects of the industrial healthcare sector, from enabling

technologies to laboratory automation and clinical robotics. Key

components of this are the MedTecLIVE Healthtech Pavilion in

cooperation with the MedtecLIVE trade fair and a two-day MedtecSUMMIT

organized by Bayern Innovativ. This offering is supplemented

by specific healthtech exhibits from the exhibitors, curated

by VDMA HealthTech. “The robotics and automation solutions of

our exhibitors play a prominent role in medical technology,“ says

Anja Schneider. “I am all the more pleased that we can now give this

application area an appropriate platform and, with the right partners,

continue to tap into an attractive visitor target group for automatica.

“

A leader on topics thanks to a high-caliber supporting program

One of the highlights of the supporting programme is munich_i, the

high-tech platform for AI and robotics, under the patronage of Bavarian

Prime Minister Dr. Markus Söder. The high-tech summit on Tuesday,

June 24, 2025, the robotics and AI special show AI.Society and

the hybrid robotics competition Robothon® are key components of

munich_i. automatica is organising munich_i together with the Munich

Institute of Robotics and Machine Intelligence (MIRMI) at the

Technical University of Munich.

automatica will once again be supplemented by an attractive

supporting program in 2025. It includes the Service Robotics Arena

and the Mesh-up as a special show on mobile robotics. On a more

than 600-square-meter course, companies will demonstrate how

driverless transport vehicles and mobile robots from different manufacturers

can be operated flexibly and efficiently.

One ticket—three trade fairs

Two parallel trade fairs supplement the automatica offering and provide

additional stimulus: Laser World of Photonics focuses on photonics

components, systems and applications, while World of Quantum

is all about trends, innovations and visions in quantum technology.

There are already numerous overlaps between the automation

and laser industries, and quantum technology holds huge potential

especially for industrial applications, for example, through the desired

performance of quantum computers. With one trade fair ticket,

visitors automatically have access to the other two events.

More than 500 exhibitors have already registered for automatica 2025.

© Messe München GmbH

Messe München GmbH

D 81823 München


page 30/41

Mit dem Code

rronline2025

dein kostenloses

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buchen

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Besuchern in Karlsruhe treffen, stehen mehr als 220

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Die LOUNGES werden zunehmend auch international

wahrgenommen – was am wachsenden Anteil von

Unternehmen aus dem Ausland deutlich sichtbar ist.

2026 werden die LOUNGES vom 24. bis 26. März

mit erweitertem Programm wieder in Karlsruhe

stattfinden – wir laden dich schon jetzt ein, als

Aussteller oder Besucher live dabei zu sein.

Die digitale Plattform cleanroom-processes.de bietet

dir die komplette Übersicht über alle Vorträge und

Aktionen, um deinen Besuch der LOUNGES zu planen.

Die rund um die LOUNGES produzierten Formate,

wie Videos und Podcasts, sowie News, Know-how

und Kontakte, die auch in den digitalen Netzwerken

verbreitet werden, sind auf cleanroom-processes.de

das ganze Jahr über online abrufbar.

Informiere dich bei den Insidern der Reinraum- und

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Buche jetzt dein kostenloses Besucher-Ticket und erhalte

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Die Plattform der Reinraum- und Prozesstechnikbranche


page 31/41

Die Aussteller der LOUNGES 2025


page 32/41

Stand

24.02.2025


page 33/41

SAVE THE DATE

24. bis 26. März 2026 · Messe Karlsruhe

Neben allgemeinen Themen, wie Regelung und Compliance, Qualifizierung und Validierung,

Service und Dienstleistungen, Messen und Kalibrieren, Ausbildung und Training sowie

allgemeine Qualitätskontrolle und Mikrobiologie fokussieren die LOUNGES 2026 die Bereiche:

• Gebäudeplanung und Architektur

• Reinraumplanung und -ausstattung

• Reinraumbetrieb und Instandhaltung

• Messtechnik und Monitoring

• Lüftung und Klimatechnik

• Bekleidung und Verbrauchsmaterialien

• Reinigung und Hygiene

• Pharmaproduktion und Prozesstechnik

• Anlagenbau und -planung

• Pharmaverpackung und Kennzeichnung

• Prozessautomation und Digitalisierung

• Steriltechnik und Biotechnologie

• Künstliche Intelligenz und virtuelle Welten

• Qualitätsmanagement und Validierung

Frühbucherrabatt für Aussteller

Aussteller der LOUNGES 2025 haben bis 25. April 2025 die Möglichkeit, ihren diesjährigen

Stand auch für 2026 zu buchen. Danach gehen nicht abgerufene Stände in den freien Verkauf.

www.cleanroom-processes.de

Die Plattform der Reinraum- und Prozesstechnikbranche


page 34/41

The victory electric combines the best of both worlds – precision

through electric drives and the advantages of ENGEL‘s

tie-bar-less technology. (Image: Engel)

The victory electric offers faster injection speeds

and more user-friendly maintenance with its

new electric injection units. (Image: Engel)

Tie-bar-less and electric for optimised production

ENGEL expands the victory series

ENGEL is expanding its renowned tie-bar-less victory injection moulding machine series with the integration of the

previous e-motion TL, now introduced as the victory electric. This innovative addition combines the strengths of tie-barless

technology with the advanced features of servo-electric drives, setting new standards in production technology.

By incorporating the successful e-motion TL into the victory series

under the name victory electric, ENGEL has restructured its portfolio

of tie-bar-less injection moulding machines, offering three distinct

categories within a single series: electric, hybrid, and hydraulic.

The machine has been upgraded with state-of-the-art drive

components for improved energy efficiency. The redesigned injection

units deliver faster injection speeds and enhanced user-friendliness.

Components are now more accessible and easier to replace,

simplifying maintenance tasks such as the servicing of the plasticising

cylinder. These improvements result in higher performance,

energy savings, and increased machine availability.

A further innovation of the victory electric is the integration of

hydraulics for clamping forces starting at 80 tonnes. This meets market

demands for a variety of tools requiring hydraulic support. Additionally,

this solution is significantly more cost-efficient than externally

supplied hydraulics, while maintaining the machine‘s compact

footprint.

The victory electric is available in clamping forces ranging from

30 to 130 tonnes, designed to meet the needs of industries requiring

high flexibility, exceptional precision, and short cycle times.

Key application areas include sectors demanding large quantities of

high-precision parts in short cycles, such as medical technology, the

automotive and electronics industries, as well as technical moulding.

With this machine, ENGEL aims to further strengthen its market

leadership in these sectors.

The victory electric delivers precision in two stages. First, its

electric injection units ensure highly accurate control of the injection

moulding process, shot by shot. This results in significantly

improved part quality and exceptionally low scrap rates - a major

advantage in cost-intensive production environments. Another

benefit of the electric drive system is its short response times. This

enables very short cycle times while maintaining consistently high

part quality. In high-volume production, where every second counts,

this provides a distinct competitive advantage.

Even distribution of clamping force across all cavities is crucial

for the production of high-quality components in high-cavity

moulds, representing the second stage of maximum precision. Part

by part, within each shot. Furthermore, the excellent platen parallelism

of tie-bar-less injection moulding machines is a key feature

for protecting moulds, which translates into reduced maintenance

costs.

The large, unobstructed mould area of the tie-bar-less design in

the victory electric also simplifies mould changes and accelerates

maintenance operations. This increases overall uptime and significantly

reduces production costs. It also enables the use of very large

and complex moulds without requiring an alternative tie-bar machine

with significantly higher clamping force. The compact design and

small footprint of the machine make it particularly advantageous for

facilities with limited space or cleanroom environments.

Since the victory electric is equipped as standard with an encapsulated

toggle lever, the risk of oil leaks and contamination is

significantly reduced. The absence of tie bars minimises airflow turbulence,

which can dislodge dust and debris in the mould area. Both

features are especially important in clean production environments,

such as in medical technology. With the specially developed optional

cleanroom package, qualifying the machine for use in cleanrooms

up to ISO Class 7, ENGEL also sets benchmarks in cleanliness. The

enclosed components and low-emission operation make the victory

electric the ideal choice for industries requiring the highest cleanliness

standards.

The expansion of the victory series through the integration of

the victory electric reflects ENGEL‘s commitment to offering solutions

for every injection moulder - with technological advancements

aimed at increasing production efficiency and reducing operating

costs. Customers benefit from a future-proof investment that guarantees

superior product quality and environmental standards, ensuring

competitiveness in demanding markets.

ENGEL AUSTRIA GmbH

A 4311 Schwertberg


page 35/41

Linear robotic system from Arburg

For Asia: Flexlift for automated

production of moulded parts

Arburg is offering the Flexlift specifically for the

Asian market. The new linear robotic system is

available with loads of 5, 10 and 15 kilograms

– each with the option of one or two vertical

axes. (Photo: Arburg)

– Exclusive: Robotic system specifically for Asia

– Flexible: Flexlift with loads of 5, 10, or 15 kilograms and

one or two vertical axes

– Reliable, fast, precise: Powerful introduction to automated

moulded part production

Arburg now offers a linear robotic system designed specifically and exclusively

for the Asian market as an entry-level solution for the automated production of

moulded parts: the Flexlift – available in six different versions. The vertical-entry

robotic system is perfectly adapted to the requirements of customers from

Asia. For example, the Flexlift can also be installed on the operating side of the

machine if required.

cisely to the respective requirements – for

example, with application-specific drives

and valve sets alongside variable positioning

of the control cabinet. This is supplemented

by easily accessible pneumatic and vacuum

interfaces for end-of-arm tooling (EOAT)

and peripheral technology. If needed, Arburg

can also implement complete turnkey

systems in its Technology Factory (ATF) in

Pinghu and additively manufacture gripper

components for the Flexlift, for example.

Arburg‘s Flexlift, which is produced exclusively

in and for Asia, has been designed to

meet the market‘s demand for a reliable, fast

and precise robotic system with an impressive

price/performance ratio.

Powerful and user friendly

The Flexlift is suitable for Allrounder injection

moulding machines in sizes 320 to 570.

The flexible robotic system is available in six

different versions: with loads of 5, 10 or 15 kilograms

and with the option of one or two

vertical axes. Typical areas of application include

the careful removal of moulded parts

and sprue, the handling of inserts, and applications

in medical technology and clean

rooms. Particles are reliably retained thanks

to the encapsulated design and a filter for

the vacuum generator.

Its low height and telescopic design mean

that the robotic system is also suitable for

confined spaces. Powerful, energy-efficient

servo motors ensure that the vertical

mould-entry axes are extremely dynamic

and precise – enabling fast removal, precise

and vibration-free movements and short

cycle times. To save energy and reduce

wear, axis speeds can be reduced if necessary.

The robust, low-maintenance technology

and optional performance-dependent

automatic lubrication ensure a long service

life and high availability.

Modular adaptability

Arburg can adapt the modular Flexlift pre-

Robotic system integrated into controller

The robotic system is quick and easy to get

up and running because the control panel

has the same interface as the machine controller.

Integration via OPC UA enables enhanced

communication and synchronisable

movements. One major advantage is that

the data sets of the machine and the robot

can be stored and retrieved together. This

central data set saves time, reduces the effort

required to manage configuration data,

and significantly increases process reliability

and production efficiency. The machine

controller can be used to start and stop the

robotic system, for example, and to display

and acknowledge alarm messages.

ARBURG GmbH + Co KG

D 72290 Loßburg


page 36/41

At the Selters site, two independent, redundant production lines ensure

a consistent and reliable supply of the CORMASTER® lightweight

material. (Photo: SCHÜTZ)

The systems produce honeycomb blocks in a highly

automated process. (Photo: SCHÜTZ)

JEC World 2025:

SCHÜTZ COMPOSITES presents

customised lightweight

solutions

At JEC World 2025, SCHÜTZ COMPOSITES will be presenting one of the most

versatile solutions for modern aerospace, vehicle construction and motorsport

applications: the high-tech lightweight material CORMASTER®. International

industry leaders are invited to discover pioneering materials and technologies at

the global trade fair for composite materials from 4 to 6 March 2025 in Paris-Nord

Villepinte. SCHÜTZ will be showcasing its CORMASTER® product portfolio for

a wide range of applications in Hall 6, Stand E55.

For four decades, the name CORMASTER®

has been synonymous with quality and innovation.

The high-tech material combines

outstanding mechanical strength with minimal

weight and is made from aramid paper,

which is shaped into a hexagonal honeycomb

structure in a high-precision process.

Thanks to its resistance to extreme temperatures,

moisture, oils and paraffin, COR-

MASTER® is suitable for demanding applications

that require maximum resilience.

The SCHÜTZ COMPOSITES portfolio includes

a wide range of product types – from

honeycomb sheets, which are also available

in both milled and thermally formed versions,

to sandwich panels and engineered

panels. CORMASTER® CN1 honeycombs

are primarily used where the main requirements

are maximum performance and low

weight. CORMASTER® C1 honeycombs

are suitable for many important structural

and sandwich applications in the aerospace

industry. CORMASTER® C2 honeycomb is

used in a range of structural and sandwich

applications in industry and sports, such as

in cars, trains, ships and high-performance

sailing yachts.

Highest production standards at SCHÜTZ

SCHÜTZ continuously invests in state-ofthe-art

technologies and manufacturing

processes to provide customers with superior

products. In recent years. the company

has been upgrading the production facilities

for its CORMASTER® products. A clean

room with an area of over 1,000 m² in Siershahn

(Germany) was added in 2021 to ensure

the highest standards of cleanliness. This

space allows the company to process excep-

The CORMASTER® honeycomb material is

based on aramid paper and is characterised

by outstanding mechanical strength and

minimal weight. (Photo: SCHÜTZ)

tionally sensitive materials such as prepregs

at the highest level and so meet even the

most demanding quality requirements of

its customers. To maximise supply security,

a second highly automated production line

has also been added to the facility in Selters

(Germany). This ensures that operations

can continue smoothly even if the first line

breaks down, as it has an independent supply

of gas, electricity and thermal oil. Certification

to EN ISO 9001 and EN 9100 guarantees

a consistently high level of production

at all manufacturing sites, covering all process

steps from development to delivery.

Throughout production, there is a strong

focus on sustainability. SCHÜTZ COMPO-

SITES uses state-of-the-art exhaust air purification

systems to reduce CO2 and pollutant

emissions. These measures underscore

the company’s commitment reducing the

use of resources for a better future.

SCHÜTZ GmbH & Co. KGaA

D 56242 Selters


page 37/41

Arburg at rapid+tct 2025

Wide range of AM applications:

From knee implants to robotic grippers

– High temperature: Freeformer 750-3X also processes materials such as Ultem and PEAK

– High performance: medical and aerospace components including multi-material combinations

– Highly interesting: switches for night trains, cartilage replacement for the knee and grippers „on demand“

From 8 to 10 April 2025, ARBURGadditive will be presenting its portfolio for additive manufacturing at stand no. 2308 in

Detroit, USA. The centrepiece will be a Freeformer 750-3X in a high-temperature version, which can process Ultem 9085

and PEAK as original granulate, for example. In addition, numerous components will demonstrate the wide range of applications,

including 3D-printed light switches as spare parts for the Austrian Federal Railways (ÖBB), TPU-based knee

implants as cartilage replacements and multi-material grippers for robotic systems.

„At rapid+tct 2025, we will be presenting innovative application

examples from our customers and development partners in addition

to the machine exhibit,“ says Martin Neff, Director Sales at

ARBURGadditive. „In addition, a wide range of materials that can

be processed with our industrial 3D printers will be on display at our

exhibition stand and will be continuously expanded. The possibility

of using cost-intensive materials several times in the Arburg Plastic

Freeforming (APC) and to return them to the material cycle is also

interesting and sustainable.“

Freeformer 750-3X in high-temperature version

At rapid + tct 2025, a high-temperature version of the Freeformer

750-3X will be presented, which can additively manufacture sophisticated

functional components from a wide range of different plastic

granulates. The build chamber can be tempered to 200 degrees Celsius

and plasticising takes place at up to 450 degrees Celsius. The

high-end machine has three discharge units so that even complex

geometries and functional multi-material combinations with support

material can be realised. This industrial 3D printer can be used

to additively manufacture and customise larger functional components

or small series quickly and flexibly using the APF process.

Wide range of materials

Plastic granules with specific approvals and certifications for applications

in the medical, electronics, mobility and aviation sectors, for

example, can also be processed. These include Ultem 9085, LMPE-

AK and PEEK. Another new addition to the APF material portfolio is

Grilamid TR 90, an amorphous PA12 material approved for food and

drinking water, which ARBURGadditive has made „3D printable“

in cooperation with Ems Chemie. In addition, break-away support

structures made from Ultem 9085, for example, can be shredded and

reused several times in the form of flakes.

Spare parts and operating resources „on demand“

A major advantage of additive manufacturing is the ability to produce

spare parts where and when they are needed. As a practical

example, light switches made of flame-retardant PC/ABS com-

With the 750-3X high-temperature Freeformer with three discharge

units, the installation space can be tempered to 200 degrees Celsius

and the original granulate is plasticised at up to 450 degrees Celsius.

(Photo: Arburg)

The Freeformer is also suitable for new application ideas in medical

technology. These include the „iKnee“ - a patient-specific implant

based on medical TPU that can be inserted into the knee as a

minimally invasive cartilage replacement. (Photo: Arburg)


page 38/41

pound are shown, which the Austrian Federal Railways (ÖBB) has

produced as required for its night trains using a Freeformer. The

Freeformer is also suitable for the fast and cost-effective production

of operating equipment and end-of-arm tools (EOAT). The production

of plant pots at Osko shows how 3D printing and automated

injection moulding processes complement each other perfectly: The

injection-moulded pots are handled gently using special packaging

automation with 3D-printed grippers that are precisely adapted to

the product. The sturdy black gripper centrepiece made of fibrereinforced

plastic is two to three times lighter and significantly more

cost-effective than aluminium. The four white gripper rings in a

hard/soft combination were produced using the APF process. The

soft gripper part is „inflated“ with compressed air, thereby fixing the

moulded part for removal from the mould.

Innovative solutions for medical technology

The Freeformer is also particularly suitable for use in cleanrooms

and innovative applications in medical technology. Typical products

are resorbable implants, breast prostheses or medical devices and

aids. At rapid + tct 2025, examples of components that will be presented

include nose and ear prostheses made from sterilisable TPE

(TM5 Med). A new application idea is the „iKnee“ - a patient-specific

implant based on medical TPU that can be inserted into the knee

as a minimally invasive cartilage replacement. A customer realises

hollow medical valve bodies on the inside with a Freeformer 750-3X,

which produces these components in an airtight and resilient multimaterial

combination of PP and TPE.

Seamless traceability and documentation

An indispensable prerequisite for the use of additively manufactured

functional components in safety-relevant areas is a reproducible

and reliable AM process. For patient-specific implants or safety-relevant

components in aeroplanes, for example, it is imperative that

the production parameters for each individual component can be

fully documented and traced. Arburg offers the „ProcessLog“ customer

portal app for this purpose. This allows a wide range of process

and build order data from APF components to be clearly visualised

and documented. This ensures transparency, high part quality and

can significantly reduce rejects and error rates.

ARBURG GmbH + Co KG

D 72290 Loßburg

Netstal strengthens global customer proximity

and establishes its own subsidiary in Mexico

The newly founded company has been operating under the name

NETSTAL Máquinas, S. de R.L. de C.V. in the premises of the former

iTech Latinoamérica in Santiago de Querétaro since January

14, 2025. Netstal Mexico, a subsidiary of NETSTAL Maschinen AG,

Switzerland, has successfully employed the talented team from

iTech Mexico into its operations. Furthermore, the owners of iTech

have independently decided to cease operations indefinitely by dissolving

their company. The new Netstal Mexico team comprises 7

employees in the areas of sales, customer service and administration.

José Lelo de Larrea has been entrusted with the management of

the Mexican Netstal subsidiary. He co-founded iTech Latinoamérica

in 2010 and successfully built up iTech as a managing partner. Since

2023, the company has been the official representative for Netstal

in the strategically important Mexican market. iTech’s co-founding

Looking forward to the new cooperation (from left to right): Renzo

Davatz (CEO Netstal), José Lelo de Larrea (Managing Director Netstal

Mexico) and Nadeem Amin (President Netstal Americas)

partners, Rod Selem and Irineu Scalisse will continue to play a valuable

role as business and technical advisors for Netstal in the region.

Renzo Davatz, CEO: “In line with our strategy, with this step we

are further expanding the global Netstal organization under the umbrella

of Krones. Following the opening of Netstal Dubai in 2024, we

are establishing the next subsidiary in the growth market of Mexico.

I would like to welcome all new employees in Mexico to the global

Netstal team and wish José Lelo de Larrea every success in his new

role as Managing Director.”

Nadeem Amin, President Netstal Americas: “We’re excited to

expand our presence in Mexico with the establishment of our new

subsidiary. This step allows us to better serve our customers by leveraging

the exceptional expertise of our new team members in PET,

closures, packaging and medical applications. With our cutting-edge

injection molding machine technology and best-in-class services,

we are committed to helping our customers maximize production

efficiency and achieve their goals. I’m thrilled to collaborate with

José Lelo de Larrea and his talented team as we continue to deliver

outstanding solutions tailored to our customers’ needs.”

José Lelo de Larrea, Managing Director Netstal Mexico: “I am

thankful to Renzo, Nadeem and the Netstal management team for

depositing their trust in me and my colleagues to lead this new chapter

for Netstal Mexico. We are very excited about this endeavor where

we will dedicate our experience focusing completely on bringing

our valued customers full local commercial and technical support. I

am very happy with the challenge and opportunity to help Netstal

bring value to the market through its high quality and technologically

advanced machines as well as peripheral equipment to complete

systems with its trusted partners.”

Netstal Maschinen AG

CH 8752 Näfels


page 39/41

The new Vaisala Indigo80 handheld device

and Vaisala Polaris process refractometers

– a match made in process heaven

The Vaisala Polaris family of process refractometers has a wide range of uses in processes where liquid concentration measurements

are required. You can use a Vaisala Polaris instrument alongside the Vaisala Indigo80 Handheld Indicator to get

a range of additional benefits in industrial processes. This blog explores some typical use cases where these benefits make

the most difference.

The compact Indigo80 Handheld Indicator

is a portable measurement device for field

sampling and calibrations, data analysis,

and diagnostics. When combined with Vaisala

Indigo compatible instruments, it offers

stable and accurate measurements of parameters

such as humidity, temperature, dew

point, carbon dioxide, hydrogen peroxide

vapor, moisture in oil, refractive index and liquid

concentration even in the face of rapid

environmental changes. With exceptional

battery capacity, a high-resolution display,

and a memory that can hold up to 5.5 million

data points, Indigo80 is a convenient way to

visualize measurements over a long period

of time and inspect readings from installed

probes to check if they require calibration. It

can also be used for data logging, spot checking,

and troubleshooting, with the display

providing visualization of data from installed

equipment. With process refractometers

it is able to display the optical image and other

information of the instrument for accurate

diagnostics view on the spot.

Indigo80 is compatible with the Vaisala

Polaris range of process refractometers,

which are used in a broad variety of process

industry applications such as crystallization,

dilution, distillation, blending, and quality

control. These are all applications where

liquid concentration measurement is key to

ensuring optimal process conditions, product

quality, process safety, and regulatory

compliance.

Vaisala Polaris uses the fundamental

concept of refractive index readings to measure

liquid concentrations, helping to maintain

safe operations in the pulp industry

with black liquor total solids measurement,

in ensuring the quality of food and beverages

by measuring sugar content, and enabling

accurate concentration measurements

in chemical production processes, among

many other uses.

Let’s look at some use cases that illustrate

the benefits of using Indigo80 together

with Polaris process refractometers.

1. Configuration and calibration

– no downtime for configuring probes

Polaris process refractometers are delivered

preconfigured, with concentration coefficients

set up for the intended application.

With an Indigo80 you can quickly and easily

adjust parameters rather than needing to remove

the probe from the process to reconfigure

it via a laptop. The Indigo80 can also

be used to change the signal damping parameters

without compromising the process.

Having a dedicated handheld device means

there’s no need to bring laptops or other devices

into the process area, which can be a

safety issue or compromise a clean room

setup. For verification purposes, Indigo80

gives you an easy way to confirm the reading

from the automation system for calibration

processes.

2. Data logging – uncovering problems

in a process

Many field devices do not store historical

data, instead taking snapshot readings that

are used in process controls or to generate

alarms if process parameters exceed set limits.

If an unexpected situation arises and

the operator is uncertain what’s causing it,

a diagnostic tool is needed. This is where

using Vaisala Polaris with Indigo80 can help

– as Indigo80 is battery powered, it can be

connected to the field device overnight, or

for a longer period. The Indigo80 enables

data comparison with that of the system in

order to determine variations over time to

help in diagnostics.

3. Maintenance – identifying

when sensors require cleaning

Although Polaris process refractometers

rarely require maintenance due to their rugged

construction and lack of consumable

and moving parts, maintenance might be

needed if the optical prism become coated

in residue, causing the quality factor to drift.

The quality factor is a numerical parameter

that indicates the cleanliness of the prism. If

drift happens, the unit will need to be removed

and cleaned – and Indigo80 can help to

identify maintenance needs by logging the

quality factor over time. If the quality factor

drifts downwards or there are significant

variations, it’s a good indication that a spot

of cleaning might be needed. Indigo80 can

also be used as a display for Vaisala Polaris

and other smart probes that don’t have their

own displays, with a choice of two views: the


page 40/41

current measurement or a graphical representation

of the probe’s historical readings.

The Indigo80 and Vaisala Polaris process

refractometer are powerful tools for

gathering valuable process insights and

improving process and end-product quality

across a variety of applications. When

used together, the benefits are magnified,

with Vaisala Polaris gathering accurate

concentration data and Indigo80 providing

a convenient way to log, access, and

visualize this data without the risk of process

downtime.

The updated firmware will become available

by the end of March. Existing customers

will also get the new features by

updating the firmware of both Polaris process

refractometers and Indigo80 handheld

devices.

Vaisala GmbH

Rheinwerkallee 2

D 53227 Bonn

Telefon: +49 228 249710

Telefax: +49 228 2497111

eMail: vertrieb@vaisala.com

Internet: http://www.vaisala.de

Innovative Light Protection Labels

for Prefilled Syringes Showcased

at Pharmapack 2025

Schreiner MediPharm, a leading developer and manufacturer of functional labels

for the healthcare industry, successfully presented its latest product developments

at Pharmapack 2025 in Paris from January 22 to 23. The innovative light

protection labels for syringes met with great interest among visitors. Schreiner

MediPharm offers them as effective protection for light-sensitive active ingredients

(APIs) such as biologics and biosimilars. The product solutions combine

light protection, safety, and functionality, and can be used for a wide range of

prefilled syringes.

Light-sensitive drugs react sensitively to UV

and light rays, which may impair their efficacy

and shelf life. Schreiner MediPharm

addresses this challenge with customized

Innovative light protection solutions:

Syringe-Closure-Wrap, Light-Protect-Label,

and Cap-Lock-Label (from top to bottom)

combine multi-level light protection,

functionality, and safety for prefilled syringes.

© Schreiner MediPharm

light protection labels that have been developed

specifically for the requirements

of light-sensitive APIs. The new functional

labels are suitable for all commonly used syringe

types and sizes—whether they are fitted

with needles or Luer lock adapters.

The functional labels are available in

three different UV and light protection levels:

Level 1 offers effective UV protection

combined with an integrated transparent

inspection window. Level 2 additionally extends

this protection to blue light while a

semi-transparent window permits viewing

the fill level. Maximum protection is delivered

by Level 3 enabling full light protection.

Resealable inspection windows can be integrated

for checking the syringe content in

its original color.

The individual light protection is avai-

lable for three different types of labels performing

specific functions. The Light-Protect-Label

protects the syringe barrel while

the Syringe-Closure-Wrap Label for higher

protection offers full coverage of the syringe

barrel and cap and has a first-opening indication

feature. The Cap-Lock Label specifically

developed for the SCHOTT TOP-

PAC® infuse syringe combines elevated

light protection with reliable first-opening

indication as well. Additionally, for instance,

graduations enabling precise dosing of the

injection and documentation labels can be

integrated to further enhance application

efficiency.

The new light protection labels from

Schreiner MediPharm enable pharmaceutical

companies to efficiently equip their

prefilled syringes for sensitive substances

with precision multi-level UV and light protection.

The label is customized to suit the

respective COC or glass syringe and can be

processed without exposure to heat. Healthcare

staff are provided with a convenient

and user-friendly solution that contributes

to patient safety.

Schreiner MediPharm

D 85764 Oberschleißheim

Impressum:

cleanroom online / W.A. Schuster GmbH · Mozartstrasse 45 · D 70180 Stuttgart · Tel. +49 711 9 64 03 50 · Fax +49 711 9 64 03 66

info@reinraum.de · www.cleanroom-online.de · GF Dipl.-Designer Reinhold Schuster · Stgt, HRB 14111 · VAT DE 147811997

Original texts and images

The contributions mentioned by name are the responsibility of the particular author. Reprinting, also of extracts, are permitted only with the approval of

the editor and with reference to the source. The publisher does not accept any responsibility for unsolicited manuscripts and illustrations. The publisher

is granted the exclusive, spatial, temporal and contentual limited right to freely use the article in unchanged or edited form for all purposes as often as

desired or to transfer it to third parties for use. This right of use relates to print and electric media (Internet, databases, data carriers of all kinds).


page 41/41

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