Wellness Foods + Supplements 1/2025

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No. 1, May 2025 

www.harnisch.com | ISSN 2364-8104 

1098/H 

2x 4x 8x 10x 

1098/H 

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1000 

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800 

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500 

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Skin health 

Allergies 

x 

400 

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0 

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Plant extracts 

Women's health 

Heart & brain health 

XQ - 200 

24 - 3 

1. 2 

Bone & joint health 

XD - 200 

XF - 300 

XG - 400 

X - 345 

X - 583 

X - 873 

Beauty from within 

Find your inner health, and let it show. 

PUREBKALE 

BLACK KALE 

SEED EXTRACT 

Detox. Purify your skin 

from the inside. 

- 

W E N - 

OPEXTAN ® 

OLIVE FRUIT 

EXTRACT 

Glow. Enjoy natural skin 

protection against 

sun damage. 

SABALSELECT ® 

SAW PALMETTO 

EXTRACT 

Grow. Encourage your 

hair’s natural thickness. 

UBIQSOME ® 

COQ10 

INDENA PHYTOSOME ® 

Boost. Slow down signs 

of skin aging. 

These statements may not comply with your country’s laws and regulations or with 

Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. 

The products are not intended to diagnose, treat, cure or prevent any disease. 

Marketers of finished products containing these ingredients are responsible 

for ensuring compliance with the applicable legal framework.

Come for our biggest ever event 

Stay for our incredible new home 

Join us in Barcelona for a nutraceutical event like no other. Source new 

products, discover the latest insights and connect with a community of 

experts. 

20-22 May 2025, Barcelona 

Vitafoods.eu.com

Editorial 

SILKE WATKINS, Editor-in-Chief 

True beauty comes from within 

Clear, radiant skin, lustrous, full hair and 

healthy fingernails are no longer just signs 

of youthfulness and vitality, they are now 

desired even in advanced age. But how does 

that work and what makes the difference? 

Care products for various skin and hair types 

and for all age groups abound. We all need 

to figure out for ourselves which ones work 

for us. 

While men with few exceptions are somewhat 

less choosy when it comes to skin and 

nails, they have long since discovered the 

“wonder” of restoring their mane to its full 

glory. Prominent examples from the sport of 

football are long since common knowledge. I 

cannot think of a famous female example at 

the moment. 

Nutrition is important as well and should 

be adapted to our personal needs and age. 

Environmental conditions, stress, inadequate 

sleep and the lack of a balanced diet 

can negatively influence the skin, hair and 

nails, even in children and adolescents. Skin 

problems are often accompanied by allergies that can begin in childhood 

and are especially bothersome in spring, when everything is in 

bloom. Yet we are not helpless in the face of these problems since 

there are remedies for (almost) everything. 

In this edition, you will find a range of articles examining the topics 

“Beauty from within” and “Allergies” along with many other aspects 

of physical and mental health. 

This year’s Vitafoods is coming up soon, held for the first time in 

Barcelona, and the organisers are promising that it will be even 

bigger and more varied than ever before. I’m really excited already 

and looking forward to familiar and new faces as well as many interesting 

conversations. 

I hope you enjoy reading this Wellness Foods & Supplements and 

look forward to seeing you in Barcelona! 

Best wishes, 

Silke Watkins 

No. 1 May 2025 

3

Contents 

Health 

Convenience Food 

Food & Beverages 

Photo © : Adobe Stock/ShniDesign 

The modern beauty landscape is witnessing 

a significant shift towards holistic wellness, 

driven by the understanding that true beauty 

stems from within. This “beauty from within” 

approach emphasizes the connection between 

overall health and outward appearance. A 

key component of this trend is the increasing 

popularity of natural ingredients, especially 

botanicals. These powerful ingredients offer 

a wide range of benefits, from combating the 

signs of aging and reducing oxidative stress to 

supporting optimal skin and hair health. 

(See cover story on page 6) 

Confectionary 

Sports Nutrition 

Contents 

Health Care 

Personal Care 

Cover story 

06 Beauty from within: The power of botanicals from the inside out 

0 Gut health 

09 Natural Pro-Digest: Bringing best-in-class prebiotic & probiotic together 

Skin health 

12 Belight 3TM : A scientifically backed formula for hyperpigmentation across all skin types 

Allergies 

16 Pycnogenol ® naturally prepares you for the next pollen allergy season 


20 Aphrodana ® : A modern aphrodisiac with a rich historical legacy 

Micronutrients 

25 Concurrent use of dietary supplements and medications: risky interaction or 

therapeutic opportunity? 

Sports nutrition 

30 Faster, higher, better: Minerals for athletic success 

Brain health 

33 Why quality ingredients matter 

Fibre 

37 Innovation in acacia gum contributes to healthier and more sustainable gummies 

Gluten-free flour 

38 Cassava flour: Gluten-free flour from the tuber 

Spray drying 

40 Contract spray drying – a matter of trust 


42 Sulforaphane, an effective ally in PMS management 

Bone and joint health 

45 Keeping bones and joints healthy for life 

Heart health 

48 Heart-healthy snacking: Science-backed strategies for cardiometabolic health 

50 Impressum 

4 No. 1 May 2025

Inflammatory 

Response 

Seasonal 

Allergies 

hay fever 

The One & Only For Respiratory Health 

www.pycnogenol.com 

*For a complete list of scientific research and further information visit our website at www.pycnogenol.com. Pycnogenol ® , French maritime pine bark extract, is a registered 

trademark of Horphag Research and its applications are protected by U.S. patents and other international patents. ©2025 Horphag Research.

Cover story 

Beauty from within: The power of botanicals 

from the inside out 

The modern beauty landscape is witnessing a significant 

shift towards holistic wellness, driven by the understanding 

that true beauty stems from within. 

This “beauty from within” approach emphasizes the connection 

between overall health and outward appearance. A 

key component of this trend is the increasing popularity of 

natural ingredients, especially botanicals. These powerful 

ingredients offer a wide range of benefits, from combating 

the signs of aging and reducing oxidative stress to supporting 

optimal skin and hair health. 

The relevance of this trend is confirmed by economics. As noted in a 

report by Grand View Research (Grand View Research, 2021 https:// 

www.grandviewresearch.com/), the global nutricosmetics market is 

projected to reach USD 9.27 billion by 2028, driven by increasing 

consumer awareness of the link between nutrition and beauty. 

The report highlights several key drivers 

for this growth, starting from an increasing 

consumer awareness: consumers are 

becoming more educated about the link 

between nutrition and skin health, hair 

health, and overall well-being. They are 

actively seeking products that address 

beauty concerns from the inside out. More, 

the growing aging population is driving 

demand for anti-aging products, including 

nutricosmetics that claim to reduce wrinkles, 

improve skin elasticity, and promote 

hair growth. 

Last but not least, ongoing scientific research 

into the efficacy of various nutrients and 

supplements in promoting beauty is further 


Cover story 

fuelling market growth. This aspect is very 

important, as consumers are becoming 

more discerning and are looking for pro ducts 

backed by scientific evidence. 

Indena is deeply attuned to the growing 

consumer demand for 'beauty from within' 

solutions and offers a portfolio of botanical 

extracts which can support skin and hair 

health. 

A healthy skin, with the power 

of nature 

The secret to vibrant skin lies in a delicate 

balance. Factors like detoxification, inflammation, 

emotional and hormonal health, and 

protection from environmental aggressors, 

especially UV rays, all play a crucial role. 

When these elements are aligned, skin radiates 

health and youthfulness. Natural ingredients 

offer powerful support, promoting the 

skin's innate ability to repair, renew, and 

maintain its long-term beauty. 

One of the most innovative products Indena 

developed specifically for skin health is 

PUREBKALE TM . It is an aqueous dry extract 

from seeds of Brassica oleracea var. virids 

(L.) (syn. Brassica oleracea var. 

acephala DC.) - Brassicaceae 

family, standardize 

to provide 

≥17 % of glucoraphanin 

by HPLC. 

This compound 

is precursor of 

sulforaphane 

(SFN), an active 

isothiocyanate 

produced when glucoraphanin 

is metabolized 

by the enzyme myrosinase, a 

compound extensively studied for its 

health- promoting properties (1). 

Indena’s black kale seed extract is sourced 

from a carefully selected Italian supplier 

based in Cesena, following a rigorous 

screening of over 20 seed samples from 

various Brassica oleracea varieties, origins, 

and suppliers. This supplier works directly 

with local farmers in the Romagna region of 

Northern Italy, providing expert support to ensure sustainable cultivation 

practices. The ideal climate and soil conditions in this area 

contribute to the superior quality of the seeds, making it one of the 

largest producing areas in Europe in for the production of black kale 

seeds. Furthermore, black kale, like all brassicas, has a nematicide 

function: the compounds contained in the roots and residues 

that remain in the field, function as a “natural pesticide” for the soil 

helping to fight nematodes, thus ensuring better growth conditions 

for subsequent production and possible less use of fertilizers. Finally, 

in line with our commitment to sustainability, the extract is produced 

using only water as solvent. 

Scientific literature supports the enzymatic conversion of glucoraphanin 

into sulforaphane by the human gut microbiota (2). This 

transformation unlocks the bioactive potential of sulforaphane, which 

has been linked to a variety of benefits like detoxifying and antioxidant 

capabilities. Specifically, sulforaphane has shown promise in 

preventing photoaging of the skin and reducing the risk of sunburns 

by modulating the effects of UV radiation. Additionally, sulforaphane 

promotes skin nourishment, making it a powerful ingredient for 

overall skin health (3-4). 

Beyond the newly launched PUREBKALE TM , Indena has a portfolio 

of extracts, backed by strong scientific data, that can benefit skin 

health. 

Some of those are formulated with Indena Phytosome ® technology 

which enhances the power of phytonutrients. They are BERBEVIS ® , 

Indena’s berberine extract, able to promote purity and smoothness 

in acne-prone skins through proven hormonal balancing effects; 

MERIVA ® , a highly bioabsorbed curcumin and a science-backed 

ingredient, able to modulate inflammatory response in favor of atopicprone 

skins and topical discomforts; QUERCEFIT ® , which has a 

natural healthy aging beneficial effect thanks to the senolytic benefits 

of quercetin. 

UBIQSOME ® , an exclusive CoQ10 

nutraceutical ingredient which 

boosts cellular energy and 

skin vitality promoting an 

enhanced absorption of 

ubiquinone in dermal 

cells. RELISSA ® , which 

delivers the benefits of 

lemon balm very effectively 

and is able to support 

mental balance and restful 

sleep, crucial for skin rejuvenation 

in favor of a radiant, youthful 

appearance. In the Indena portfolio 

for the health of skin are also LEUCOSELECT ® , a high-quality grape 

seed extract, rich in oligomeric proanthocyanidins (OPCs), which 

provide excellent antioxidant protection and brightening benefits, 


7

Cover story 

and OPEXTAN ® , which fosters skin 

renewal and sun exposure protection 

thanks to the power of olive 

fruits extract from southern 

Italy olives. 

Botanicals to nourish 

the hair 

Botanicals, rooted in timehonored 

practices, are now 

recognized for their powerful 

benefits in hair care. These 

nutrient-rich ingredients, with their antioxidant, 

anti-inflammatory, and strengthening properties, work synergistically 

to nourish the hair and scalp. 

The Indena portfolio includes two pro ducts 

specifically able to help hair health. 

SABALSELECT ® is a premium, highly 

standardized Serenoa repens extract 

which unleashes hair’s potential 

supporting hair growth, improved 

texture, and a noticeably fuller 

appearance, thanks to the traditional 

benefits of saw palmetto. 

MILLET is proven to promote scalp 

health, enhance hair density, boost 

growth, and improve overall hair appearance 

exploiting the efficacy of standardized Panicum 

miliaceum extract. Indena remains committed to pioneering 

the “beauty from within” movement by providing high-quality, scientifically-backed 

botanical solutions. As consumer awareness and 

demand for proactive health and beauty care continue to grow, 

Indena will continue to dedicate its resources to developing innovative 

and effective ingredients that empower individuals to nurture 

their well-being from the inside out. 

References 

1. Sulforaphane Glucosinolate Monograph. Volume 15, 

number 4. Alternative Medicine Review. 2010 

2. Cascajosa-Lira et al., Phytomedicine 130 (2024) 155731 

3. Šamec et al., Critical Reviews in Food Science and Nutrition, 

DOI: 10.1080/10408398 (2018) 1454400 

4. Moskwa et al., Nutrients (2023), 15, 3594 

For more information, please contact 

Indena S.p.A. 

Laura Bo, External communication 

laura.bo@indena.com 

www.indena.com 


Gut health 

Photo © : Shutterstock/Miljan Zivkovic 

Natural Pro-Digest: Bringing best-in-class 

prebiotic & probiotic together 

Lallemand Health Solutions and 

FrieslandCampina Ingredients have 

successfully advanced their established 

partnership on the synbiotic concept 

Natural PRO-Digest. Recent developments 

have provided comprehensive 

evidence supporting the synergistic 

benefits of pre- and probiotics, demonstrating 

significant positive mechanistic 

effects on gut health and recognized 

overall by real-life consumers. 

Market drivers 

Holistic health starts in the gut, with 68 % 

of consumers recognizing the link between 

digestive health and overall health 1 . The 

synbiotic category is growing in popularity, 

with 47 % of probiotic health supplements 

containing prebiotics in their formulation in 

2020, rising to 53 % in 2024 2 . Digestion, 

immunity, and general health are the topreviewed 

health benefits in the probiotic and 

prebiotic markets 3 , with 53% of consumers 

expressing a desire to improve their digestive 

health 1 . 

A synergistic synbiotic solution to support gut comfort 

A synbiotic is defined as “a combination of live microorganisms 

and substrate(s) selectively utilized by host microorganisms that 

confers a health benefit to the host. [International Scientific Association 

for Probiotics and Prebiotics; Swanson, 2020].” Host microorganisms 

comprise both commensal microbiota and probiotics. The 

Natural PRO-Digest solution combines FrieslandCampina Ingredients 

prebiotic Biotis ® GOS-OP High Purity and Lallemand Health 

Solutions probiotic B. lactis Lafti ® B94 to create synergistic benefits 

that supports gut comfort. 

Prebiotic Biotis ® GOS-OP High Purity 

Biotis ® GOS-OP High Purity is a high-purity galacto-oligosaccharide 

(GOS). Biotis ® GOS increases Bifidobacterium in the gut* 4 improves 

gut comfort* 5 and has a positive influence on constipation in adults 

by increasing defecation frequency 6 and easing defecation* 7,8 . This 

prebiotic also reduces gastrointestinal symptoms such as bloating, 

and flatulence* 9 . 

Probiotic B. lactis Lafti ® B94 

Selected from among 40 bifidobacteria strains for its good synergy 

with prebiotics 10 , B. lactis Lafti ® B94 has been studied in nine clinical 

studies on gut conditions from infancy to adulthood 11 . It supports 


9

Gut health 

a healthy microbiota, reinforces gut barrier integrity, increases the 

production of short-chain fatty acids* 11 , and helps relieve abdominal 

discomfort such as bloating and constipation* 12,13,14 . Bifidobacterium 

species are known to produce acetate as the main short-chain 

fatty acid metabolite, and Lafti ® B94 in particular is a high acetate 

producer thanks to its acetate kinase enzyme metabolism. 

A recent review published in 2023, Tremblay et al., reaffirms the 

significant beneficial effects of B. lactis Lafti ® B94 in infant and children’s 

gut health alone or as a synbiotic. 

Synergistic benefits enhancing microbial activity 

Simulation of the colon Using SIFR ® technology 15 assessed the impact 

of Biotis ® GOS and Lafti ® B94, individually and as a syn biotic, on gut 

microbiota composition andactivity. 16 The prebiotic Biotis ® GOS-OP 

High Purity increases beneficial bifidobacteria and as a nutrient for 

the microbiota it boosts gut microbiota activity. This results in a higher 

production of various SCFAs. Probiotics do not provide additional 

fermentable substrates to the gut microbiota, unlike prebiotics. Among 

Bifidobacterium species, Lafti ® B94 specifically produces acetate. The 

synbiotic Lafti ® B94 and Biotis ® GOS-OP High Purity work synergistically 

to boost gut microbiota and promote SCFA production. These 

effects may contribute to digestive health and gut comfort*. Further 

analyzes are ongoing and more results are coming soon. 

Easy and tasty product: 4-week 

consumer compliance 

The study shows that on average, 85 % of 

consumers recognized this product as easy 

to use and easy to integrate into their daily 

routine and 97 % of consumers appreciated 

the product’s taste from the first date and it 

continued throughout the study. 

Significant improvement in selfreported 

gut comfort after just 1 

week and throughout the study 

The study showed significant improvement in 

self-reported gut comfort after just one week, 

with continued improvement throughout the 

study. A stunning x2.5 consumers experienced 

a positive effect on gastrointestinal 

health after just 1 week. 

Role of short-chain fatty acids 

The intestinal microbiota plays a central role in the human body, 

impacting mucosal immunity, barrier integrity, gut health, and the 

regulation of host metabolic health. The gut microbiota constitutes an 

ecosystem including trillions of bacteria classified into different phyla, 

with specific families highlighted for their health benefits. The gut 

microbiota is responsible for fermenting non-digestible food components 

in the large intestine, resulting in the production of short-chain 

fatty acids (SCFA) such as acetate, butyrate, and propionate 16 . Most 

of the health benefits of SCFA are attributed to butyrate, which can 

be produced directly by certain species or indirectly through crossfeeding 

with acetate and lactate as precursors 17 . SCFAs offer several 

health benefits, including serving as a source of energy for epithelial 

cells, enhancing barrier integrity, providing anti-inflammatory effects, 

supporting metabolic health, and offering immunoregulatory and 

microbiota-gut-brain support. 

Tested by over 100 consumers for gut comfort support 

A consumer study tested Natural Pro-Digest for gut comfort support 

with 107 participants aged 18 to 65 years old. Participants dissolved 

one sachet containing 1.3 g High-Purity Biotis ® GOS and 5B Lafti ® 

B94, per day for 28 days in a cold glass of water or milk and consumed 

it during or directly after a meal. They filled in self-affirmed questionnaires 

about their experience and gut comfort at various intervals 

throughout the study 18 . 


In addition, significant improvement in gastrointestinal health-related 

quality of life were observed specifically on improvement of daily 

activities and enhancement of peacefulness. 

Conclusion 

You have 

news? 

FrieslandCampina Ingredients and Lallemand Health Solutions have 

brought together the best-in-class prebiotic and probiotic ingredients 

in Natural Pro-Digest, offering a synergistic synbiotic solution to 

support gut comfort. This innovative product demonstrates significant 

benefits for digestive health, backed by scientific research and positive 

consumer feedback. 

*Check your local regulatory requirements before use as different 

claims may be made depending on the regulations applicable in 

each country. 

References 

1. FMCG Gurus, Digestive Health Survey, June 2024, 16,000 consumers. 

2. Mintel analysis (December 2024). 

3. FMCG Gurus, Probiotic Survey, May 2024, 16,800 consumers. 

4. Looijesteijn et al., 2024. 

5. Schaafsma et al., 2022 

6. Schoemaker et al., 2022 

7. Teuri et Korpela, 1998. 

8. Sairanen et al., 2007. 

9. Wilson et al., 2019. 

10. Crittenden et al., 2001. 

11. Tremblay et al., 2023. 

12. Basturk et al., 2016. 

13. Erdogan et al., 2012. 

14. Islek et al., 2014. 

15. Abbeele et al., 2023. 

16. Flint et al., 2012. 

17. Data on file 2024, SIFR ® technology, CryptoBiotix. 

18. Data on file 2024. 

For more information, please visit 

lallemand-health-solutions.com/en/ or contact our 

team at healthsolutions@lallemand.com 

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NEWSLETTER 


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info@harnisch.com · www.harnisch.com

Skin health 

Photo © : Adobe Stock/curto 

Belight 3 TM 

: A scientifically backed formula for 

hyperpigmentation across all skin types 

Belight 3TM is capitalizing on the growing consumer interest 

in scientifically backed, effective and safe formula against 

hyperpigmentation. With clinical validation first conducted 

on Asians and later on Caucasians, and high consumer satisfaction, 

it secures a strong competitive edge in the rapidly 

growing beauty and wellness market. 

Scientific research has long established that an even skin tone plays a 

key role in perceived attractiveness. A study published in Frontiers in 

Psychology confirms that uniform skin tone is subconsciously linked 

to youth, vitality, and health. However, hyperpigmentation remains a 

significant concern for many, particularly among the mature demographic, 

affecting millions worldwide. 

Hyperpigmentation manifests as dark spots, melasma, and suninduced 

pigmentation, primarily caused by excessive melanin 

production due to UV exposure, hormonal fluctuations, and aging. 

While not harmful, these pigmentary changes can negatively impact 

self-confidence, driving a surge in demand for safe and effective 

solutions. 

Hyperpigmentation: 

understanding its biological causes 

Human skin exhibits a diverse range of 

tones, from very light to very dark, primarily 

determined by melanin, a pigment naturally 

produced by the skin that forms a mosaiclike 

pattern on the skin’s surface. 

Melanin biosynthesis, or melanogenesis, is a 

complex process that occurs within the melanosomes 

of melanocytes. Several enzymes 

regulate this mechanism, with tyrosinase 

playing a key role in melanin formation. This 

enzyme catalyzes the conversion of tyrosine 

into melanin, which affects skin pigmentation 

(1). 

Hyperpigmentation arises when melanin 

production becomes excessive, resulting in 


Skin health 

uneven pigmentation and the formation of 

dark spots. Various factors, including UV 

exposure, aging, and pollution, contribute to 

this overproduction by generating oxidative 

stress, which disrupts cellular balance and 

triggers increased melanin synthesis (1). 

Since dark spots and uneven skin tone 

are common concerns, there is a growing 

demand for natural solutions to address them. 

One effective approach is inhibiting tyrosinase 

activity, which helps regulate melanin 

production and control hyperpigmentation. 

In order to scientifically validate the efficacy of this formula and to 

investigate potential synergy between the ingredients, in vitro tests 

were carried out to assess the ability of each ingredient and the whole 

blend to inhibit tyrosinase. 

The results confirm that each of the ingredients in Belight 3TM inhibit 

tyrosinase, as shown by the decrease in absorbance. In addition, statistical 

analysis revealed a synergistic effect between the ingredients, 

resulting in an 85 % inhibition of tyrosinase activity, reinforcing the efficacy 

of their combination against hyperpigmentation (Fig. 1) (4). 

Targeting hyperpigmentation at its 

root with Belight 3TM 

Belight 3TM is a patented formula designed 

to target hyperpigmentation. Activ’Inside’s 

R&D approach began with an understanding 

of the mechanisms involved in the overproduction 

of melanin. As previously explained, 

UV exposure and oxidative stress stimulate 

tyrosinase, an enzyme responsible for 

melanin synthesis. Leveraging this knowledge, 

an extensive review of scientific 

litera ture was conducted to identify natural 

ingredients that target these pathways. The 

result is a powerful formula combining four 

complementary active compounds. 

The first ingredient is grape seed extract from 

the Champagne region of France. Rich in 

flavanol monomers, it is a powerful antioxidant 

and has been proven to reduce tyrosinase 

activity and limit UV-induced melanin overproduction 

(2). The second ingredient is licorice 

root extract, which is scientifically backed 

for its action on tyrosinase, and its protective 

properties against UV and oxidative stress (3). 

The last ingredients are grape pomace from 

France, rich in viniferin, and vitamin C. 

These two antioxidants are known for their 

ability to inhibit tyrosinase and regulate skin 

pigmentation. 

These 4 ingredients are scientifically backed 

for their action on pigmentation, conferring 

Belight 3TM a triple action on: the regulation 

of tyrosinase, the protection of skin against 

UV damages and an antioxidant action to 

combat oxidative stress. 

Fig. 1: Tyrosinase activity without (control) or with Belight 3TM ingredients and 

Belight 3TM blend 

Clinically backed benefits of Belight 3TM on dark spots and 

skin evenness 

Once the in vitro mechanism had been validated, efficacy was 

evalu ated in a human model. A real-world study was carried out by 

Activ’Inside on 100 French participants, who were supplemented 

with 300 mg of Belight 3TM for 2 months under dermatological supervision. 

The medical assessor noticed a 30 % reduction in age related 

dark spots and a 40 % reduction in sun related dark spots, resulting 

in a 30 % more even complexion (Fig. 2). After 2 months, more than 

70 % of participants noticed fewer dark spots on their face and 79 % 

felt that the results were visible quickly, with an average delay of 11 

days. Belight 3TM ’s efficacy and speed of action were thus confirmed, 

with a satisfaction rate of 82 %. 

To confirm these results clinically, a first clinical study was conducted 

in Bangkok, where conditions are favorable to hyperpigmentation 


13

Skin health 

(sunny and polluted city, mature and Asian skin type). Fifty-eight Asian 

participants (phototypes III to IV, 45-65 years old) with dark spots were 

supplemented with 300 mg of Belight 3TM per day for 3 months. This 

study showed a significant improvement in the skin brightening and in 

the lightening of dark spots compared to placebo (4). 

participants. Before and after photographs 

illustrated these effects, confirming a lightening 

of dark spots and an overall improvement 

in skin evenness (Fig. 4). 

In summary, the results of these two clinical 

studies show that Belight 3TM lightens dark 

spots and improves skin complexion in all 

conditions, meaning at all ages, for all skin 

types and in all environments. 

Fig. 2: Dermatologist's assessment of dark spots and skin complexion before 

and after supplementation 

A second study was conducted in less favorable conditions for hyperpigmentation, 

in winter, in two cities in northern Italy. Sixty-six Caucasian 

participants (phototypes I to III, 28-52 years old) took the same 

supplement for 3 months. The aim was to measure the color of the 

dark spots using the Individual Typological Index (ITA°) and the evenness 

of the skin using dermatologist’s notation. The ITA° is a dermatological 

parameter correlated with melanin content measured with a 

spectrophotometer at baseline, then after 6 and 12 weeks (5). The 

higher the ITA°, the lighter the skin. The results showed a significant 

increase in ITA°, indicating a significant lightening of dark spots after 

6 and 12 weeks. After 12 weeks, the dark spots are 22.4 % lighter 

(Fig. 3). 

Fig. 4: Belight 3TM 's effect on dark spots lightening 

at baseline and after 6 and 12 weeks 

Belight 3TM : A Science backed, 

sustainable and adaptable ingredient 

for diverse consumer needs 

Fig. 3: ITA° change from baseline of facial dark spots 

Belight 3TM is built on a foundation of sustainability, 

quality, and inclusivity. By sourcing 

grapes from biodiverse regions in France, 

we ensure the highest biochemical quality 

while supporting local agriculture and minimizing 

environmental impact. The formula 

goes further by upcycling byproducts from 

the winemaking industry, transforming waste 

into valuable bioactive compounds. This 

circular approach aligns with our commitment 

to reducing waste and promoting a 

sustainable economy. 

The dermatological evaluation confirmed the efficacy of Belight 3TM , 

with a significantly more participants in the Belight 3TM group showing 

an improvement in dark spots visibility than in the placebo group at 

6 and 12 weeks. At the end of the study, more than 50 % of participants 

showed improvement, meaning that the effect of the product 

is relevant. Skin complexion evenness was also improved in 72 % of 

Manufactured in France under strict European 

regulations, Belight 3TM guarantees the 

highest standards of safety and quality, free 

from allergens, pesticides, and contaminants. 

It is suitable for vegan, halal, and 

kosher diets, thus catering to diverse cultural 


Skin health 

and dietary needs. Backed by scientific 

research, Belight 3TM is clinically proven to 

reduce hyperpigmentation and can be used 

as a standalone ingredient or blended with 

other actives to create customized nutricosmetic 

solutions whether in capsule or 

gummy form. 

Belight 3TM represents a breakthrough in the 

fight against hyperpigmentation, offering 

a clinically validated, science backed solution 

that works across all skin types and 

environments. By targeting the root causes 

of melanin overproduction with a synergistic 

blend of natural ingredients, it effectively 

reduces dark spots and evens skin 

tone. Beyond its proven efficacy, Belight 3TM 

upholds sustainability and inclusivity, 

ensuring a high-quality, eco-conscious solution 

that meets diverse consumer needs. As 

demand for safe and natural hyperpigmentation 

solutions continues to grow, Belight 3TM 

stands out as a powerful, adaptable ingredient 

for the future of nutricosmetics. 

References 

(1) Chen, Juanjuan, et al. « Oxidative Stress in the Skin: Impact and Related Protection ». 

International Journal of Cosmetic Science, vol. 43, no 5, octobre 2021, p. 495 509. DOI.org 

(Crossref), https://doi.org/10.1111/ics.12728. 

(2) Yamakoshi, Jun, et al. « Lightening Effect on Ultraviolet-Induced Pigmentation of 

Guinea Pig Skin by Oral Administration of a Proanthocyanidin-Rich Extract from Grape 

Seeds ». Pigment Cell Research, vol. 16, no 6, décembre 2003, p. 629 38. PubMed, https:// 

doi.org/10.1046/j.1600-0749.2003.00093.x. 

(3) Xu, Zhongyi, et al. « A Pilot Study of Oral Tranexamic Acid and Glycyrrhizin Compound in 

the Treatment of Recalcitrant Riehl’s Melanosis ». Journal of Cosmetic Dermatology, vol. 18, 

no 1, février 2019, p. 286 92. PubMed, https://doi.org/10.1111/jocd.12797. 

(4) Pouchieu, Camille, et al. «Effect of an Oral Formulation on Skin Lightening: Results 

from In Vitro Tyrosinase Inhibition to a Double-Blind Randomized Placebo-Controlled Clinical 

Study in Healthy Asian Participants ». Cosmetics, vol. 10, no 5, octobre 2023, p. 143. 

www.mdpi.com, https://doi.org/10.3390/cosmetics10050143. 

(5) ursi, Francesco, et al. « Clinical Efficacy of Belight3TM on Dark Spot Pigmentation in 

Caucasian Subjects ». Cosmetics, vol. 12, no 1, février 2025, p. 27. www.mdpi.com, https:// 

doi.org/10.3390/cosmetics12010027. 


Activ’Inside 

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Competence 

in Magnesium 

Precision. Purity. Performance. 

◆ Manufacturing excellence in Magnesium Salts 

◆ Over 40 Magnesium Salts for diverse applications 

◆ Tailor-made solutions for food and food supplements 

◆ Uncompromising quality Made in Germany

Allergies 

Photo © : Adobe Stock/Pics With Love 

Pycnogenol ® naturally prepares you 

for the next pollen allergy season 

Dr. Franziska Weichmann 

Allergies are a very common health problem with 5 to 50 % 

of the world population - that is approx. 400 million to 4 

billion people suffering from allergic rhinitis (1). Allergic 

rhinitis is an inflammation in the nose, triggered by an overreaction 

of the immune system to allergens in the air (2). 

If allergic rhinitis occurs only seasonally and against tree 

or grass pollen, it is called hay fever. The prevalence of 

allergic rhinitis depends on factors like geographic location, 

population density and age and is reported to increase over 

the years, as climate change is associated with increased 

seasonal pollen exposures (1). As a result, the prevalence of 

allergies is expected to increase by more than 50 % in the 

next few decades, particularly in colder climates that previously 

were spared from higher rates of seasonal pollen allergies 

(1). 

Typical signs and symptoms are sneezing, a runny or stuffy nose and 

red, itchy, watery and swollen eyes (2). Many people who have allergic 

rhinitis also suffer from asthma, allergic conjunctivitis or atopic dermatitis 

(2). The most common treatment of allergy symptoms are oral 

or nasal antihistamines or corticosteroids, which unfortunately come 

with side effects like sleepiness, sleep disturbances, 

headaches, anxiety or depression, 

especially when taken over a longer time. 

Pycnogenol ® French maritime pine bark 

extract is a natural solution for a safe and 

evidence-based management of allergies 

without side-effects. Pycnogenol ® has shown 

efficacy against allergy symptoms, asthma 

and to normalize immune responses by 

attenuating general inflammation. 

Pycnogenol ® relieves allergy symptoms 

Several clinical trials suggest a relieve of 

allergy symptoms after intake of Pycnogenol ® 

(3-10). In a randomized double-blind 

placebo-controlled trial, researchers found 

that Pycnogenol ® intake improved allergic 

rhinitis symptoms in subjects allergic to 

birch pollen. (3). Eye symptoms decreased 


Allergies 

by 35 % and nasal symptoms by 20.5 % compared to placebo. The 

number of patients requiring rescue antihistamines during the study 

period was 26 % lower in the Pycnogenol ® group than in the placebo 

group. In addition, birch specific antibody titre after 12 weeks was 

lowered by 36 % with Pycnogenol ® compared to placebo. During the 

season of high birch pollen count, nasal allergy symptoms stayed 

consistently lower with Pycnogenol ® compared to placebo. 

A similar study confirmed Pycnogenol ® ’s dose-dependent effect 

on reducing histamine release from mast cells (6). In addition, the 

researchers observed that Pycnogenol ® decreased the activation of 

several pro-inflammatory markers in the immune cells. These results 

help to explain Pycnogenol ® ’s preventive action against allergic 

immune reactions. 

Pycnogenol ® reduces asthma symptoms 

Asthma is a very common chronic inflammatory lung disease manifesting 

in symptoms like cough, shortness of breath, chest tightness 

and wheezing (11). Possible triggers for asthmatic episodes include 

allergies, pollutants, microbes and oxidative stress (11). The efficacy 

of Pycnogenol ® supplementation on allergic asthma management 

was investigated in several clinical studies (12-14). 

Another study investigated the effects of Pycnogenol ® intake on the 

skin’s reaction to a histamine injection which causes redness and 

swelling in healthy individuals (4). Pycnogenol ® supplementation 

significantly reduced the wheal and flare response, by decreasing the 

redness area around the injection point by 44 % and by shortening the 

time of its complete disappearance by 64 %. 

In addition to these direct anti-histaminic effects, an in vitro study 

investigated Pycnogenol ® ’s effects on immune cells that are involved 

in allergic reactions. Pycnogenol ® was found to reduce the release of 

histamine from the immune cells (mast cells) dose-dependently (5). 

Interestingly, Pycnogenol ® was at least as effective for inhibiting histamine 

release as a widely used anti-histaminic medication, sodium 

cromoglycate. 

In a double-blind, placebo-controlled cross-over study, the effects 

of Pycnogenol ® supplementation for four weeks on chronic asthma 

patients was investigated (12). The patients’ lung function was 

assessed by analysis of the “forced expiration volume in 1 second” 

(FEV 1 

) test, representing the percentage of lung volume, exhaled 

in a second. In asthmatics, the FEV 1 

is generally reduced as their 

breathing is restricted. After Pycnogenol ® supplementation the 

patients could exhale 70 % of their lung volume as compared to 59 % 

at trial start and 63 % in response to placebo. Additionally, the study 

participants rated their asthma symptoms regarding severity. Four 

weeks of Pycnogenol ® intake led to a reduction of symptom severity 

by 20.8 %, whereas it was reduced by only 2.1 % in placebo patients. 

Furthermore, Pycnogenol ® significantly reduced pro-inflammatory 

mediators (leukotrienes) in the blood of patients, as compared to both 

baseline values and placebo. Leukotrienes are known to play a role 

in a variety of allergic and inflammatory conditions, including asthma, 

allergic rhinitis, and eczema. 

Photo © : Adobe Stock/Pete 


17

Allergies 

A 6-month study with 79 patients investigated the effects of 

Pycnogenol ® on mild to moderate allergic asthma due to dust mite 

allergy (13). Asthma symptoms, such as dry couch, chest tightness, 

wheeze, shortness of breath or nighttime awakenings significantly 

improved with Pycnogenol ® supplementation. In addition, the 

patients were able to reduce the use of salbutamol asthma inhaler 

per day by half. 

Most asthmatics develop the disease during childhood, most of them 

before they reach the age of five years. A double-blind, placebocontrolled 

study investigated the effects of Pycnogenol ® on 60 children 

aged 6 to 18 years with mild to moderate asthma (14). The study 

showed that the breathing capacity improved significantly already after 

1 month intake of Pycnogenol ® , as assessed by measuring FEV 1 

. The 

severity of asthma symptoms as well as leukotriene levels in the urine 

decreased drastically after one month of Pycnogenol ® supplementation 

and further decreased significantly throughout the trial period. 

The treatment with placebo had no significant effect on leukotriene 

levels or asthma symptoms. The most compelling outcome of the 

study is the dramatically reduced necessity of using albuterol rescue 

inhalers as severe asthma attacks appeared much less frequently. 

After 1 month, 8 out of 30 children taking 

Pycnogenol ® didn’t require rescue inhalers 

anymore and 18 children were completely 

off the inhaler after the 3-month supplementation. 

Pycnogenol ® normalizes the immune 

response 

Inflammatory processes are a key mechanism 

in allergy development (15). Pycnogenol ® ’s 

potent anti-inflammatory activities help 

explain the mechanism regarding its regulation 

of allergic symptoms (7, 16-19). Already 

after 5 days of daily intake, a study reported 

that Pycnogenol ® significantly prevented the 

up-regulation of pro-inflammatory enzymes 

5-LOX and COX-2 (16). In another study, 

plasma samples of volunteers after intake 

of Pycnogenol ® showed a statistically significant 

inhibition of NF-κB activation by 15.5 % 

and matrix metalloproteinase 9 (MMP-9) 

release by 25 %, two important regulators in 

the inflammation process (17). The expression 

of a majority of pro-inflammatory genes 

is governed by NF-κB, such as leukotrienes, 

cytokines and adhesion molecules. 


Allergies 

Some of these molecules are known to play 

an important role in the onset of asthma. The 

partial inhibition of NF-κB lowers the sensitivity 

level for triggering an immune response, 

which will help prevent an asthmatic attack. 

MMP-9 is a connective tissue degrading 

enzyme, which greatly affects pulmonary 

function of asthmatic patients. In another 

study, statistically significant inhibition of 

inflammatory molecules COX-1 and COX-2 

was observed after intake of Pycnogenol ® 

(18). These anti-inflammatory effects were 

confirmed in a study with immune cells 

(macrophages) that are involved in allergic 

reactions (7). Pycnogenol ® significantly 

decreased the elevated production of the 

inflammation markers IL-1 β and IL-6 as well 

as MMP-9 in a concentration dependent 

manner. In a similar study Pycnogenol ® 

suppressed the upregulation of inflammation 

markers and blocked the activation of 

an allergy-related pathway in inner layer of 

lungs (airway epithelial cells), treated with an 

allergen (19). In addition to its anti-inflammatory 

action, Pycnogenol ® has potent antioxidant 

effects that help to reduce triggers of 

allergic asthma attacks (20-22). 

Pycnogenol ® French maritime pine bark 

extract is a safe and natural and evidencebased 

solution to effectively relieve the 

main symptoms of allergies. It was shown 

to help with allergic rhinitis, allergic asthma 

and flare reactions without adverse effects. 

In addition, Pycnogenol ® offers potent antiinflammatory 

and antioxidant properties for 

a healthy immune system. 

For a complete list of scientific research 

and for further information, please visit 


References 

1. Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, et al. International consensus 

statement on allergy and rhinology: Allergic rhinitis – 2023. Int Forum Allergy Rhinol. 

2023;13(4):293-859. 

2. Wheatley LM, Togias A. Allergic Rhinitis. New England Journal of Medicine. 

2015;372(5):456-63. 

3. Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, et al. A randomized, 

double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol 

for improving allergic rhinitis symptoms. Phytother Res. 2010;24(8):1115-9. 

4. Belcaro G, Feragalli B, Hosoi M, Dugall M, Cornelli U. Pycnogenol ® reduces the wheal and 

flare response to histamine in normal subjects. Minerva Biotecnologica 2016;28:114-9. 

5. Sharma SC, Sharma S, Gulati OP. Pycnogenol inhibits the release of histamine from mast 

cells. Phytother Res. 2003;17(1):66-9. 

6. Choi YH, Yan GH. Pycnogenol inhibits immunoglobulin E-mediated allergic response in 

mast cells. Phytother Res. 2009;23(12):1691-5. 

7. Shin IS, Shin NR, Jeon CM, Hong JM, Kwon OK, Kim JC, et al. Inhibitory effects of 

Pycnogenol(R) (French maritime pine bark extract) on airway inflammation in ovalbumininduced 

allergic asthma. Food Chem Toxicol. 2013;62:681-6. 

8. Ross SM. Allergic Rhinitis: A Proprietary Extract of Pinus pinaster Aiton (Pycnogenol) 

Is Found to Improve the Symptoms Associated With Allergic Rhinitis. Holist Nurs Pract. 

2016;30(5):301-4. 

9. Günel C, Demirci B, Eryilmaz A, Yilmaz M, Meteoglu I, Omurlu IK, et al. Inhibitory Effect 

of Pycnogenol((R)) on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis. Balkan 

Med J. 2016;33(6):620-6. 

10. Unsal AIA, Kocaturk T, Gunel C, Meteoglu I, Omurlu IK, Cakmak H, et al. Effect of 

Pycnogenol on an experimental rat model of allergic conjunctivitis. Graefes Arch Clin Exp 

Ophthalmol. 2018;265(7):1299-304. 

11. Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391(10122):783- 

800. 

12. Hosseini S, Pishnamazi SS, SMH Farid, F, Farid R, Watson R. Pycnogenol in the management 

of asthma. J Med Food. 2001;4(4):201-9. 

13. Belcaro G, Luzzi R, Cesinaro di Rocco P, Cesarone MR, Dugall M, Feragalli B, et al. 

Pycnogenol improvements in asthma management. Panminerva Med. 2011;53(3):57-64. 

14. Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an 

adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-32. 

15. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature. 

2008;454(7203):445-54. 

16. Canali R, Comitato R, Schonlau F, Virgili F. The anti-inflammatory pharmacology of 

Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. Int Immunopharmacol. 

2009;9(10):1145-9. 

17. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, et al. Inhibition 

of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after 

ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1. 

18. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, et al. Inhibition 

of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French 

maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2005;60(1):5-9. 

19. Liu Z, Han B, Chen X, Wu Q, Wang L, Li G. Pycnogenol ® ameliorates asthmatic airway 

inflammation and inhibits the function of goblet cells. DNA and Cell Biology 2016;35:1-10. 

20. Chovanova Z, Muchova J, Sivonova M, Dvorakova M, Zitnanova I, Waczulikova I, et al. 

Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering 

from attention deficit/hyperactivity disorder. Free Radic Res. 2006;40(9):1003-10. 

21. Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. Supplementation 

with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and 

alters plasma lipoprotein profile. Lipids. 2002;37(10):931-4. 

22. Enseleit F, Sudano I, Periat D, Winnik S, Wolfrum M, Flammer AJ, et al. Effects of Pycnogenol 

on endothelial function in patients with stable coronary artery disease: a double-blind, 

randomized, placebo-controlled, cross-over study. Eur Heart J. 2012;33(13):1589-97. 


Dr. Franziska Weichmann, 

Manager of Scientific Communications 

and Product Development at 

Horphag Research 



19


Photo © : Adobe Stock/fizkes 

Aphrodana ® : A modern aphrodisiac with 

a rich historical legacy 

Ivo Pischel 1 , Björn Feistel 2 , Ralf Spreemann 2 , Cynthia G. Suarez 2, *, Andressa Blainski 2 

In today's fast-paced world, maintaining a healthy libido 

can be challenging. While numerous pharmaceutical solutions 

exist, there is a growing interest in natural alternatives. 

Aphrodana ® , a proprietary extract of Turnera diffusa 

(commonly known as Damiana), offers a promising natural 

solution. This article explores the historical use, health 

benefits, and recent scientific studies supporting the efficacy 

of Aphrodana ® in enhancing sexual health and overall 

well-being. 

The common/trivial name for Turnera diffusa 

Willd., or Damiana diffusa var. aphrodisiaca 

(Ward.) Urb., mainly Damiana, is used in 

French, German and Italian. The corresponding 

plant family is Passifloraceae. 

Comprehensive reviews about Damiana have 

been published and describe its pharmacological 

benefits, which are attributed to 

a diverse array of bioactive compounds 

including flavonoids, (poly)phenolic compounds, 

terpenoids, and essential oils. These 

compounds may collectively contribute to 

various activities such as aphrodisiac, anxiolytic, 

spasmolytic, antimicrobial and adaptogenic 

effects (1, 2). 

Historical, traditional and 

modern use 

Fig. 1: Plant picture of Damiana (Turnera diffusa Willd) 

Damiana has a rich history of use among 

indigenous cultures in Central and South 

America. The ancient Maya civilization 

revered Damiana as a potent aphrodisiac 



and tonic. Historically, Damiana was used 

to enhance sexual desire, alleviate sexual 

dysfunction, and promote overall vitality. 

Its traditional applications include treating 

sexual debility, digestive issues, and as a 

general wellness tonic. 

Traditional preparations include tea infusions, 

where 2-4 g of the dried herb are 

taken three times per day (3). Hydroethanolic 

extracts and tinctures are also used, 

with the most common daily dose being up 

to 12 g herbal raw material equivalents (4). 

Nowadays, Damiana is still used as a tea 

and in liqueurs. In addition, Aphrodana ® has 

proven to be a suitable ingredient for modern 

nutraceuticals and pharmaceutical convenience 

products such as tablets and gummies 

and is available worldwide (5). 

Extract characterization 

The pharmacological benefits of Damiana 

are attributed to its diverse array of bioactive 

compounds. Key constituents include flavonoids, 

(poly)phenolic compounds, terpenoids, 

and essential oils, whereas the main 

active bioactive phytochemicals are Acacetin, 

Pinocembrin, Luteolin-, and Apigeninglycosides. 

These compounds collectively 

contribute to its aphrodisiac, anxiolytic, and 

spasmolytic effects (6). 

One proprietary extract of Damiana is 

Aphrodana ® , which is clinically proven, and 

phytochemically characterized. In framework 

of this development, it was shown that 

ethanol-water concentrations of 60-80 % w/w 

exhibited the highest activity. Additionally, 

a specific technological process involving 

the use of suitable vehicles must be implemented 

to achieve a physically and chemically 

stable ingredient. This unique ingredient 

is the subject of a worldwide patent WO 

2008071684 application (7). 

Aphrodana ® ’s fingerprint reveals a complex 

extract rich in flavonoids such as flavones 

and flavanones, which can be present as 

aglycones or in glycosylated form. The 

high-performance thin-layer chromatogram 

(HPTLC) (Fig. 2) displays an abundance 

of well-defined zones that 

quali tatively define its flavonoid 

fingerprint and help 

prevent adulteration or the 

use of low-quality ingredients. 

The identified flavonoids 

include rutin, apigenin derivatives, 

luteolin derivatives, 

acacetin, pinocembrin, and 

others, which may contribute 

to pharmacological benefits 

associated with Aphrodana. 

Fig. 2: HPTLC of Damiana extract 

(Aphrodana ® on lane 1, reference 

substances on 2), capable for 

quality assurance (adulteration 

etc); Thin-layer chromatogram 

method for flavonoids according 

to BHP 1996 (Monograph: 

Damiana). 

Aphrodisiac effects via aromatase inhibition 

Scientific studies have validated the traditional use of Damiana as 

an aphrodisiac. This effect of Aphrodana ® is linked to its ability to 

inhibit the enzyme aromatase (Table 1), which converts testosterone 

into estrogen, thereby maintaining higher testosterone levels. The 

balance of androgen and estrogen, as well as the testosterone level 

in the human body is closely associated with sexual behaviour and 

activity. Additionally, Aphrodana ® has been shown to enhance sexual 

behavior in in vitro models by modulating neurotransmitter pathways, 

including dopamine, noradrenaline, and serotonin (8). 

Test substances 

Aphrodana ® 95 

Acacetin 1.4 

Apigenin 15 

Pinocembrin 3.1 

Aromatase inhibition (IC 50 

/ [µg/ml]) 

Tab. 1: Estimation of aphrodisiac effects via aromatase inhibition tests of 

Aphrodana ® and selected phytoconstituents. 

Moreover, a study conducted by Estrada-Reyes et al. demonstrated 

that Damiana extracts significantly improve sexual performance in 

male rats by activating the NO-cGMP pathway, which is crucial for 

erectile function (9). Another study by Arletti et al. reported enhanced 

sexual activity in rats treated with Damiana extracts, further supporting 

its pro-sexual effects (10). Zhao et al. investigated 24 compounds 

isolated from Damiana for their aromatase activity and found that 

acacetin and pinocembrin could significantly suppress the aromatase 

enzyme (11). 


21


Sexual arousal via Phosphodiesterase-5 (PDE-5) 

inhibition 

One of the significant findings about Aphrodana ® is its ability to inhibit 

PDE-5, an enzyme targeted by popular erectile dysfunction medications 

such as Sildenafil. While PDE-5 inhibitors are generally not 

considered aphrodisiacs, as they do not directly influence libido, the 

increased ability to attain an erection may be perceived by users as 

enhanced sexual arousal. Studies have shown that Damiana extracts 

exhibit varying potential to inhibit PDE-5 activity (Table 2). 

tigated in hippocampus slice preparations, 

where Aphrodana ® , compared to placebo, 

significantly attenuated this response, as 

evidenced by a marked reduction the amplitude 

of population spikes (Fig. 3). 

Extraction solvent Water Ethanol 

30 % w/w 

PDE-5 Inhibition: 

IC 50 

/ [µg/mL] 

Ethanol 

70 % w/w 

>30 15-20 10-15 >30 

Ethanol 

99 % w/w 

Tab. 2: Inhibition of PDE-5 of different Damiana extracts in dependency of 

the extraction solvent. 

The specialized extract Aphrodana ® demonstrated an IC 50 

value 

of 5 µg/mL, indicating potent PDE-5 inhibitory activity, which may 

contribute to improved erectile function (12). 

Modulation of brain receptors for anxiolysis 

and mood enhancement 

Damiana’s anxiolytic properties contribute to its efficacy as a natural 

aphrodisiac. Anxiety and stress are common factors that negatively 

impact sexual performance and desire. Research has shown that 

Damiana extracts exhibit significant anxiolytic effects comparable 

to those of diazepam, a well-known anti-anxiety medication. These 

effects are primarily mediated through the modulation of GABA 

receptors in the brain (13, 14). 

Recent studies have highlighted Damiana’s role in neurotransmitter 

modulation. Aphrodana ® has been shown to inhibit the reuptake of 

dopamine, noradrenaline, and serotonin, neurotransmitters that are 

crucial for mood regulation and sexual desire. This reuptake inhibition 

significantly enhances the availability of these neurotransmitters, 

thereby promoting mood elevation and increased libido (15). 

Neurotransmitter Dopamine Noradrenaline Serotonin 

IC 50 

± SD [µg/mL] 2.7 ± 0.1 84.3 ± 18.1 237.4 ± 7.9 

SD - standard deviation 

Fig. 3: Changes in neural signal amplitude with 

placebo or Aphrodana ® (60 mg/kg) following 

single or multiple stimulation. The figure shows 

that the brain activity was less excitable (less 

active) when Aphrodana ® was taken compared to 

the placebo. 

This modulation is associated with anxiolytic 

effects, as AMPA antagonism has 

been linked to stress reduction and mood 

enhancement (15). 

In summary, this dual effect on neurotransmitters 

and AMPA receptors likely contributes 

to Aphrodana ® ’s role as a sexual stimulant 

by enhancing mood and reducing 

anxiety. 

Manyfold mode of actions 

Several bioactivities have been proposed to 

explain the effect of Aphrodana ® , as shown 

below (15). 

Tab. 3 Reuptake inhibition of the monoamine neurotransmitter dopamine, 

noradrenaline, and serotonin. 

Anxiolytic effect via AMPA modulation 

Additionally, Damiana modulates AMPA (alpha-amino-3-hydroxy- 

5-methyl-4-isoxazolepropionic acid) receptors, which play a key 

role in excitatory neurotransmission in the brain. Preclinical studies 

have shown that Damiana reduces glutamatergic neurotransmission 

by antagonizing AMPA receptor activity. These effects were inves- 

Fig. 4. Multiple modes of action contribute to 

Aphrodana ® ’s overall effectiveness. 



Clinical studies and safety 

Aphrodana ® ’s efficacy and safety have been 

validated through several clinical studies. 

A notable study involving 66 male participants 

(40-55 years) with mild to moderate 

erectile dysfunction demonstrated significant 

improvements in erectile function 

and overall quality of life after supplementation 

with Aphrodana ® . The study utilized 

the International Index of Erectile Function 

(IIEF-5) and the SF-9 quality of life questionnaire 

to measure outcomes (16). 

Moreover, there were no serious adverse events or significant changes 

of laboratory values related to the Aphrodana ® . 

Another non-interventional study investigated the effects of 

Aphrodana ® in a finished product called libiLoges ® on female patients 

experiencing a lack or loss of sexual desire (17). The study included 

70 women, of whom 35 (mean age 46.1±10.9 years) completed 

the eight-week treatment with 450 mg three times daily. The study 

revealed significant improvements in sexual function, as measured 

by the Female Sexual Function Index (FSFI-d, p


enhancing libido, improving mood, and reducing anxiety. Preclini cal 

and clinical studies confirm the efficacy and safety of Aphrodana ® 

for both men and women, demonstrating positive effects on sexual 

performance, quality of life, and stress management. 

Aphrodana ® represents an appealing natural alternative to pharmacological 

treatments, particulary for individuals who prefer a holistic 

approach. With its rich historical tradition, modern scientific validations, 

and proven safety at recommended dosages, Aphrodana ® 

holds significant potential for improving sexual well-being and overall 

quality of life. However, further clinical studies are needed to expand 

the current findings and fully elucidate the potential of this unique 

extract. 

Fig. 6: Significant improvement in sexual function measured as Female 

Sexual Function Index (FSFI) 

Safety profile 

Aphrodana ® boasts an excellent safety profile. Safety data of the 

aforementioned human trial showed no blood-glucose interferences 

or alterations in kidney or liver parameters (SGOT, SGPT, Creatinine, 

Urea) in serum samples of the subjects (16). 

Additionally, decades of documented use of damiana leaf preparations 

in various countries have not reported any serious side effects 

in the standard literature. Monographs on herbal safety indicate that 

acute and subchronic toxicity studies have shown no significant 

adverse effects at therapeutic doses (19). 

Furthermore, an extensive up-to-date review of relevant scientific 

databases has not revealed any case reports of serious or severe 

adverse effects or any critical toxicological data. Based on its longterm 

use and additional toxicological tests, Aphrodana ® can be 

considered safe at recommended doses. 

Conclusion 

Aphrodana ® , a modern extract derived from the traditional plant 

Damiana, offers a scientifically validated natural solution for supporting 

sexual health and overall well-being. Its versatile mecha nisms of action, 

- including aromatase and phosphodiesterase-5 (PDE-5) inhibition, 

as well as the modulation of key neurotransmitters such as dopamine, 

noradrenaline, and serotonin - make it an effective agent for 


The Authors: 

1 

Dr. Ivo Pischel Consulting, Lacher Weg 1, 

53547 Rossbach, Germany 

2 

Finzelberg GmbH & Co.KG, Koblenzer Str. 

48 – 56, 56626 Andernach, Germany 

*Corresponding author: Cynthia G. Suarez; 

cynthia.suarez-rizzo@finzelberg.com 

References (in Vancouver Style) 

(1) Bauer R. Damiana. Z Phytother. 2017;38:275–80. 

(2) Szewczyk K, Zidorn C. Ethnobotany, phytochemistry, and bioactivity of the genus 

Turnera (Passifloraceae) with a focus on damiana – Turnera diffusa. J Ethnopharmacol. 

2014;152:424-43. 

(3) Nueva Farmacopea Mexicana de la Sociedad Farmacéutica México. Monograph Damiana, 

Turneraceae (Leaves). 3rd edition, Oficina Tipografica de la Secretaría de Fomento, Mexico, 

1896. 

(4) The British Pharmaceutical Codex, Monograph Damiana. The Pharmaceutical Press, 

London, 1934. 

(5) Finzelberg GmbH & Co. KG, Andernach, Germany. Aphrodana ® – Live Your Love. [online]. 

[Accessed 19.02.2025]. Available from: https://finzelberg.com/aphrodana/ 

(6) Van Wyk BE, Wink M. Medicinal Plants of the World - An Illustrated Scientific Guide to 

Important Medicinal Plants and Their Uses. Wallingford, UK: CABI Publishing;·2017. 

(7) Feistel B, Kreuter MH, inventors; Finzelberg GmbH & Co. KG, applicant. Special extract, 

and use thereof for the prevention of cyclic guanosine monophosphate (CGMP) decomposition. 

PCT patent WO2008071684. 2008 June 19. 

(8) Feistel B, Appel K, Pischel I. Traditional aphrodisiac Turnera diffusa Willd. – new pharmacological 

aspects about Damiana. Poster at the Phytotherapie Konferenz, Vienna, 

Austria, 2018. 

(9) Estrada-Reyes R, Carro-Juárez M, Martínez-Mota L. Pro-sexual effects of Turnera 

diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway. J Ethnopharmacol. 

2013;146(1):164-72. 

(10) Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A. Stimulating property 

of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats. 

Psychopharmacology. 1999;143(1):15-19. 

(11) Zhao Y, Dasmahapatra AK, Khan SI, Khan IA. (2008). Anti-aromatase activity of the 

constituents from Damiana (Turnera diffusa). J Ethnopharmacol. 2008;120(3):387-93. 

(12) Feistel B, Walbroel B, Benedek B. Damiana (Turnera diffusa Willd.) – a traditionally 

used aphrodisiac as modern PDE-5 inhibitor. Poster at the 58 th Intern. Congress and annual 

meeting of the society for medical plant and natural product research, Berlin, Germany, 

2010. 

(13) Losi G, Puia G, Garzon G, de Vuono MC, Baraldi M. Apigenin modulates GABAergic and 

glutamatergic transmission in cultured cortical neurons. Eur J Pharmacol. 2004;502(1- 

2):41-46. 

(14) Kuchernig JC, Sexuelle Unlust – Wirkmechanismen des natürlichen Aphrodisiakums 

Damiana (Turnera diffusa). J. Gynäkol. Endokrinol. (CH). 2021 · 24:120–7. 

(15) Heiner F, Feistel B, Appel K. Influence of traditional Turnera diffusa var. aphrodisiaca 

(Damiana) extract on monoamine- and glutamate receptor-mediated neurotransmission. 

Poster at the 12 th World Congress on Polyphenols Applications, Bonn, Germany, 2018. 

(16) Feistel B, Walbroel B. Traditional aphrodisiac Turnera diffusa WILLD new human 

aspects. Poster at the 15 th International Congress PHYTOPHARM, Nuremberg, Germany, 

2011. 

(17) Rotmann AR, Mordhorst N, Klein T, Kassen A. Damiana for the Treatment of Female 

Sexual Interest/Arousal Disorder – Results of a Multicentre Non-Interventional Study. Z 

Phytother. 2021;42: 241–8. 

(18) Ito TY, Trant AS, Polan ML. A double-bind placebo-controlled study of ArdinMax, a 

Nutritional Supplement for Enhancement of Female Sexual Function. J Sex Marital Ther. 

2001;27:547-9. 

(19) Gardner Z, McGuffin M. American Herbal Products Association’s Botanical Safety 

Handbook. 2 nd ed. Milton Park, UK: Taylor & Francis; 2013. 



Photo © : Adobe Stock/Generative AI 

Concurrent use of dietary supplements and 

medications: risky interaction or therapeutic 

opportunity? 

Laura Ingenlath 

Drugs and micronutrients often use the 

same transport and metabolic pathways 

in the body. Therefore, there is always 

a possible interaction between these 

substances, which can lead to undesirable 

side effects or interactions. 

As little attention is currently paid to 

this topic, there are still many reports 

of negative effects on the course of 

illnesses or various complaints. But are 

the interactions between food supplements 

and medicines always negative? 

Taking food supplements and medicines 

at the same time has become common 

practice for many people in recent years. 

More and more patients are turning to vitamins, 

minerals or herbal preparations as 

a supplement - whether for prevention, to improve their well-being 

or to support ongoing therapy. According to surveys, around one in 

three adults regularly consume dietary supplements, often without 

consulting a doctor. 

This development brings with it both opportunities and risks: on the 

one hand, certain micronutrients can have a useful supplementary 

effect - for example, to alleviate therapy-related side effects or 

to compensate for increased requirements. On the other hand, the 

uncritical or unsupervised combination of supplements and medicines 

harbors the potential for clinically relevant interactions. 

Incidental finding: grapefruit interaction 

It has long been known that there are interactions when drugs and food 

are taken at the same time. Probably the best-known example of this 

is the interaction between grapefruit juice and felodipine (prescription 

medication for high blood pressure and angina pectoris). By chance, 


25


P450 (CYP). A well-known example is St. 

John’s wort, which acts as a strong inducer 

of CYP3A4 and can therefore reduce the 

plasma levels of numerous drugs, such 

as oral contraceptives, immunosuppressants 

or antidepressants. Conversely, inhibitors 

of these enzymes can also increase 

the concentration and thus the risk of side 

effects of drugs (Czigle, Nagy, Mladenka , 

Tóth & OEMONOM, 2023). 

Photo © : Adobe Stock/Mhee Offset 

David G. Bailey and his colleagues discovered in a clinical study in 

1989 that grapefruit juice can influence the pre-systemic metabolism 

of felodipine and thus reduce the absorption of the drug via the intestinal 

wall (Bailey, Malcom, Arnold & Spence, 2002). 

Subsequently, at least 20 other drugs were examined for a potential 

interaction with grapefruit juice. It was found that the effect of drugs 

with naturally lower oral bioavailability in particular can be impaired 

by grapefruit juice intake. Clinically relevant interactions could be 

probable for most dihydropyridines, terfenadine, saquinavir, cyclosporine, 

midazolam, triazolam and verapamil and may also occur 

with lovastatin, cisapride and astemizole (Bailey, Malcom, Arnold & 

Spence, 2002). 

Pharmacokinetic and pharmacodynamic principles 

The effect of drugs in the body is the result of complex processes 

that are determined by pharmacokinetics (absorption, distribution, 

metabolization and excretion) and pharmacodynamics (effect on 

the target structures). Dietary supplements can intervene in each of 

these stages - partly through direct interactions with active ingredients 

and partly by influencing the body’s own transport and enzyme 

systems (Sandritter, McLaughlin, Artman & Lowry, 2017). 

A classic example is the impairment of absorption: cations such as 

calcium, magnesium, zinc or iron can form poorly soluble complexes 

with certain drugs - such as antibiotics from the tetracycline group 

or fluoroquinolones. This chelation reduces the bioavailability of the 

medication, sometimes considerably. Dietary fibers or plant extracts 

with a high tannin content can also inhibit the absorption of drugs 

(Czigle, Nagy, Mladenka, Tóth & OEMONOM, 2023). 

Another critical point is the influence on drug metabolism, in 

particular by modulating hepatic enzymes such as cytochrome 

Supplements and drugs can also influence 

each other at the pharmacodynamic level, 

for example through synergistic or antagonistic 

mechanisms of action. For example, 

the additional intake of omega-3 fatty acids 

can lead to an increased tendency to bleed 

in patients taking anticoagulants - an effect 

that can become clinically relevant, particularly 

when taken at the same time as NSAIDs 

(Kapoor et al., 2021). 

These examples show that dietary supplements 

should by no means be regarded as 

“harmless” or “free of side effects” - especially 

not in combination with prescription 

drugs. This makes it all the more important 

to be aware of potential interactions and to 

consider them when providing supplement 

advice. 

Critical micronutrients with interaction 

potential 

Although many micronutrients are essential 

for health, they can lead to relevant interactions 

when taken at the same time as 

certain medications - especially with highdose 

or long-term supplementation. Some 

of the most clinically significant substances 

and their potential interactions are presented 

below. 

Calcium, magnesium, iron, zinc 

These minerals can impair the absorption of 

numerous medications in the small intestine 

via chelation. Particularly affected are antibiotics 

such as tetracyclines and fluoroquinolones 

(e.g. doxycycline, ciprofloxacin), 

whose bioavailability can be significantly 

reduced by taking them at the same time 

as calcium or magnesium supplements. 

The recommendation is to keep at least two 


hours between taking such minerals and the 

medication (Nechiflor, Luca & Gales, 2024). 

Vitamin K 

Vitamin K is directly linked to the effect of 

coumarin-type oral anticoagulants (e.g. 

phenprocoumon, warfarin). A sudden 

change in vitamin K intake - for example 

through supplements or foods with a high 

vitamin K content - can impair anticoagulation 

and increase the risk of thrombosis or 

bleeding. A constant intake is essential for 

these patients (Tan & Lee, 2020). 

St. John’s wort (Hypericum perforatum) 

Although not a classic vitamin or mineral, St. 

John’s wort is often taken as a herbal dietary 

supplement with a mood-enhancing effect. It 

is considered a strong inducer of CYP3A4, an 

enzyme involved in the metabolism of many 

drugs. As a result, it can reduce the effectiveness 

of numerous drugs - including the 

contraceptive pill, antidepressants, immunosuppressants 

and anticoagulants. The interactions 

are well documented and sometimes 

clinically serious (Roby, Anderson, Kantor, 

Dryer & Burstein, 2000). 

Omega-3 fatty acids 

Omega-3 preparations, especially in higher 

doses, can have a slightly blood-thinning 

effect. In combination with anticoagulants or 

platelet aggregation inhibitors (e.g. acetylsalicylic 

acid, clopidogrel), the risk of bleeding 

may increase. Even if this effect is not always 

clinically relevant, it should be taken into 

account, especially during surgical procedures 

(Javaid, Kadhim, Bawamia, Cartlidge, 

Farag & Alkhalil, 2024). 

These examples show that even “natural” 

or over-the-counter supplements have a 

potential for interactions that should not be 

underestimated. This is particularly critical 

in vulnerable patient groups such as the 

elderly, patients with multiple morbidities or 

those on polymedication. 

Potential benefits of concomitant 

supplementation 

Despite possible risks and interactions, the 

simultaneous intake of food supplements 

No. 1 May 2025


and medicines is not problematic per se. On the contrary: in certain 

constellations, targeted supplementation can even be therapeutically 

useful - provided it is evidence-based, individually tailored and 

professionally supervised. 

Vitamin D during corticosteroid therapy 

Glucocorticoids such as prednisone have a negative impact on 

calcium and vitamin D metabolism and promote the development 

of secondary osteoporosis in the long term. Numerous professional 

societies therefore recommend the accompanying supplementation 

of vitamin D - sometimes also in combination with calcium - to 

prevent bone mass loss, especially with long-term use or in patients 

at risk (Homik, Suarez-Almazor, Shear, Cranney, Wells & Tugwell, 

1998). 

Coenzyme Q10 in statin therapy 

Statins inhibit endogenous cholesterol synthesis, but also interfere 

with the body’s own production of coenzyme Q10 - an essential 

component of mitochondrial energy production. A deficiency of 

coenzyme Q10 is associated with muscular side effects (myopathies). 

Studies show that a supplemental intake of coenzyme Q10 

can improve muscle tolerance - even if the evidence is not yet conclusive 

(Lamperti et al., 2005). 

Vitamin B12 and folic acid when taking metformin 

Long-term metformin therapies, which are common in type 2 

diabetes, can impair the intestinal absorption of vitamin B12. An 

undetected B12 deficiency can lead to hematological and neurological 

symptoms. In combination with folic acid deficiency, the 

homocysteine level can also increase, which is associated with an 

increased cardio vascular risk. Regular monitoring and, if necessary, 

supplementation is therefore recommended for metformin patients 

(Reinstatler, Qi, Williamson, Garn & Oakley, 2012). 

Magnesium with proton pump 

inhibitors (PPI) 

Long-term use of PPI can disrupt magnesium 

absorption and lead to a clinically relevant 

deficiency. Symptoms such as fatigue, 

muscle cramps or cardiac arrhythmia are 

often not associated with hypomagnesemia 

in practice. Targeted supplementation can 

counteract this, but should be accompanied 

by laboratory diagnostics (Cundy & Dissanayake, 

2008). 

These examples show that dietary supplements 

can be a useful addition to pharmacotherapy 

when used correctly and for the right 

indication. The decisive factor here is a wellfounded 

risk-benefit assessment, taking into 

account individual health parameters and 

the overall medication profile. 

Recommendations for practice 

The simultaneous use of medicinal products 

and food supplements requires careful 

consideration, especially for people with 

chronic illnesses, polypharmacy or in sensitive 

phases of life such as pregnancy and old 

age. The following practical recommendations 

are helpful in recognizing and avoiding 

possible interactions and at the same time 

making optimal use of potential benefits: 

1. seek professional advice 

Supplements - like medicines - should not 

be taken uncritically or solely on the basis 

of advertising or internet research. Consultation 

with medical or pharmaceutical specialists 

and qualified nutritionists is essential, 

especially if you are taking medication at the 

same time. 

2. note when to take supplements 

To minimize interactions, it can be useful to 

separate supplements and medications - for 

example, minerals and certain antibiotics. 

The intake instructions on the preparations 

should be observed and adjusted individually 

in case of doubt. 

Photo © : Adobe Stock/Vitalii 

3. keep a medication and supplement plan 

Complete documentation of all substances 

taken - including over-the-counter preparations 

and herbal remedies - is the basis for 



The simultaneous intake of dietary supplements 

and medicines has long since 

become part of everyday therapeutic practice 

- both in outpatient and inpatient care. 

It harbors both risks and opportunities: while 

certain combinations can reduce the effectiveness 

of medication or increase undesirable 

effects, other targeted supplements offer valuable support for 

pharmacotherapy. 

It is crucial that supplements are not regarded as harmless or “free 

of side effects”. Rather, a differentiated, scientifically based approach 

to micronutrients is required, particularly in chronically ill patients, 

the elderly and patients on complex medication. The systematic 

recording of potential interactions, structured advice and interdisciplinary 

cooperation between doctors, pharmacists and nutritionists 

are key components of safe and effective combination therapy. 

Only if risks are known and benefits are specifically exploited can the 

potentially “dangerous mixture” become a useful supplement - in the 

sense of an individual, holistically oriented nutrient supply. 

Photo © : Adobe Stock/Alexandr 

a well-founded risk assessment. A digital 

or written plan can help to identify interactions 

at an early stage when taking a medical 

history. 

4. question quality and dosage 

Not all dietary supplements on the market 

are sensibly formulated or sufficiently tested. 

High-dose preparations in particular carry 

an increased risk of interactions. Therefore, 

high-quality products with an evidencebased 

composition should be preferred. 

5. take patient-centeredness and 

individuality into account 

Not every supplement makes sense for 

every person. Age, previous illnesses, lifestyle, 

nutritional status and genetic predispositions 

influence the need for and tolerance 

of micronutrients. An individual 

ana lysis is the key to safe and effective 

combination therapy. These recommendations 

are intended to help exploit the potential 

of dietary supplements in therapy without 

jeopardizing drug safety. Ultimately, it is the 

conscious, informed use of both substance 

classes that enables sensible and patientoriented 

application. 

References 

Bailey, D. G., Malcom, J., Arnold, O. & Spence, D. (2002). Grapefruit juice-drug interactions. 

Br. J. Clin. Phamacol., Vol. 46, Issue 2, p. 101-110. 

Cundy, T. & Dissanayake, A. (2008). Severe hypomagnesemia in long-term users of protonpump 

inhibitors. Clin. Endocrinol., 69; 338-341. 

Czigle, S., Nagy, M., Mladenka, P., Tóth, J. & OEMONOM (2023). Pharmacokinetic and pharmacodynamic 

herb-drug interactions part I. Herbal medicines of the central nervous 

system. PeerJ. Nov. 15:11:e16149. 

Homik, J., Suarez-Almazor, M. E., Shea, B., Cranney, A., Wells, G. A. & Tugwell, P. (1998). 

Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst 

Rev., Apr 27;1998(2):CD000952. 

Javaid, M., Kadhim, K., Bawamia, B., Cartlidge, T., Farag, M. & Alkhalil, M. (2024). Bleeding 

Risk in Patients Receiving Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and 

Meta-Analysis of Randomized Clinical Trials. J. Am. Heart Assoc., Vol. 3, No. 10. 

Kapoor et al. (2021). Association Between Omega-3 Fatty Acid Levels and Risk for Incident 

Major Bleeding Events and Atrial Fibrillation: MESA. J. Am. Heart Assoc., May 

27;10(11):e021431. 

Lamperti, C. (2005). Muscle Coenzyme Q10 Level in Statin Related Myopathy. Arch Neurol. 

62(11):1709-1712. 

Nechiflor, M., Luca, C. M. & Gales, C. (2024). Interactions of Antibacterial Antibiotics with 

Magnesium and Zinc. Int. J. Inn. Res. Med. Sci., Vol. 9, No. 01, p. 50-58. 

Reinstatler, L., Qi, Y. P., Williamson, R. S., Garn, J. V. & Oakley, G. P. (2012). Association of 

Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements: The 

National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care, 35(2):327– 

333. 

Roby, C. A., Anderson, G. D., Kantor, E., Dryer, D. A. & Burstein, A. H. E. (2000). St John’s Wort: 

effect on CYP3A4 activity. Clin Pharmacol Ther. May; 67(5):451-7. 

Sandritter, T., McLaughlin, M., Artman, M. & Lowry, J. (2017). The Interplay between Pharmacokinetics 

and Pharmacodynamics. Pediatr. Rev 38 (5): 195-206. 

Tan, C. S. S. & Lee, S. W. H. (2020). Warfarin and food, herbal or dietary supplements interactions: 

A systematic review. Br. J. Clin. Phamacol., Vol. 87, No. 2, p. 352-374. 


Laura Ingenlath, MSc Nutrition Therapy 

laura.ingenlath@outlook.de 


29


Photo © : Fotolia/EpicStockMedia 

Faster, higher, better: 

Minerals for athletic success 

Minerals are the foundation of modern sports nutrition – 

providing energy, strengthening bones, regulating hydration, 

promoting recovery, and more. At a time when both athletic 

performance and health are increasingly important, nutrients 

such as Magnesium, Iron, Calcium and Zinc play a critical 

role in supporting the body. An “active diet” enables athletes 

– from ambitious high intensity athletes to health-conscious 

silver agers – to enhance performance, improve fitness, and 

fully enjoy the “rush” of physical activity. 

Mineral salts for athletes 

Minerals are essential nutrients that support numerous functions in 

the body. Magnesium, Iron, Calcium, and Zinc, in particular, have a 

significant impact on athletic performance and recovery: 

Magnesium 

Magnesium is a true all-rounder and indispensable for the human 

body. It activates more than 300 enzymes participating in various 

metabolic processes. Magnesium is crucial for muscle and nerve 

activity and helps maintain a normal heart rhythm (1). It supports 

muscle contraction and relaxation and reduces muscle soreness 

(2). Magnesium is necessary for energyproducing 

processes, is involved in protein 

biosynthesis, and plays an important role in 

glucose metabolism. For athletes exposed 

to both physical and cardiovascular stress, 

these multiple functions make Magnesium 

especially important. Organic salts such as 

citrates or bisglycinates are easily digestible 

and provide optimal Magnesium supply, 

ideal for athletes. 

Iron 

Iron is key for the formation of red blood 

cells, which carry oxygen throughout the 

body. Iron also contributes to energy supply 

and supports the immune system – a criti cal 

factor in staying fit during intense physical 

activity (3). Choosing the right Iron salt is 

important for tolerability and effectiveness. 

Ferrous bisglycinate is considered to be one 

of the best tolerated Iron salts with excellent 

bioavailability. Another high-quality source 



of Iron is encapsulated Ferrous Fumarate: 

highly bioavailable and without a metallic 

note, making it the perfect choice for direct 

consumption sticks. 

Calcium 

Calcium is fundamental to bone health 

and is of great importance for the body. 

For athletes, an adequate calcium intake is 

especially important to strengthen bones and 

reduce the risk of stress fractures. Insufficient 

calcium intake can impair performance 

and reduce skeletal strength (4). But 

Calcium is much more than a bone building 

block: It controls muscle contraction, regulates 

heart rate, aids in the transmission of 

nerve impulses, and helps regulate blood 

pressure and fluid balance. It is also involved 

in many other processes such as cell division 

and energy and fat metabolism (5). One 

interesting source of Calcium is Calcium 

citrate malate – it is better absorbed than 

many other Calcium products, has a high 

bioavailability, and is gentle on the stomach. 

Zinc 

When it comes to bone health, a third 

mineral is crucial alongside Calcium and 

Magnesium: Zinc. A growing number of 

studies show that Zinc contributes significantly 

to bone health. Zinc supports collagen 

formation, promotes bone mineralization, 

and is needed for bone metabolism (6). As 

an indispensable micronutrient, Zinc has 

many functions in the human body. It is one 

of the most powerful antioxidants, reduces 

markers of oxidative stress such as C-reactive 

protein, and protects the body from 

inflammatory processes, contributing to 

faster muscle recovery (4, 7). Zinc is also key 

to the immune system. For optimal supply of 

Zinc, Zinc citrate and Zinc gluconate are the 

preferred choices, as both are well absorbed 

by the body. 

During intense physical activity, the body 

loses not only water, but also major electrolytes 

such as Magnesium, Calcium, Sodium, 

and Potassium. These minerals are essential 

for maintaining muscle and nerve function 

and regulating fluid balance. A disrupted electrolyte balance can 

lead to impairments such as fatigue, muscle cramps, and prolonged 

recovery times. Replenishing lost electrolytes is just as important for 

maintaining performance and well-being. 

Mineral-rich sports drinks or electrolyte supplements can effectively 

replenish lost minerals and fluids, helping to maintain optimal hydration 

levels during training and competition. Hypotonic drinks are ideal 

for this purpose (8). Taste is also a key consideration. Citrates, gluconates 

and lactates are well-suited because of their good solubility and 

pleasant, mildly refreshing taste. 

Endurance sports – focus on energy, recovery 

and performance 

In endurance sports, continuous energy supply and efficient recovery 

are paramount. Magnesium, Iron and Zinc play a crucial role. Endurance 

athletes have an increased need for oxygen and energy – and 

therefore for Iron and Magnesium. Magnesium and Iron are key 

elements in energy metabolism and help reduce fatigue. At the same 

time, Zinc strengthens the immune system and supports cell regeneration, 

which is beneficial for repairing minor tissue damage. 

Adequate mineral intake is also necessary to maintain performance 

over long periods of time and to prevent fatigue. Many sports nutrition 

products contain multiple minerals. By using mineral blends, production 

and processing of sports nutrition products can be optimized. 

Customizable mineral premixes from Dr. Paul Lohmann ® with highly 

bioavailable organic salts such as citrates or bisglycinates specifically 

support performance, recovery and electrolyte balance in athletes. 

Sports Anemia – often overlooked 

Optimal iron status is the foundation for athletic performance, 

training, and health. Iron is a functional component of O 2 

-carrying 

proteins such as hemoglobin for oxygen transport in the blood and 

myoglobin for oxygen storage in the muscles. Moreover, Iron is neces- 

Hydration – more than just fluid 

management 

Photo © : Fotolia/LIGHTFIELD STUDIOS 


31


Powerful mineral salts for maximum performance 

For athletes, nutrient tolerance and bioavailability are major considerations. 

Choosing the right Mineral salt makes the difference. Organic 

compounds such as citrates, malates or bisglycinates are most suitable. 

They are easy to digest, gentle on the stomach and characterized 

by high bioavailability. Thanks to their fast and efficient absorption, 

they are the perfect way to supply the body with essential 

nutrients – especially during periods of intense exertion and rapid 

recovery. Whether for powders, energy bars, drinks or direct sticks – 

Dr. Paul Lohmann ® offers the right solution for every sports nutrition 

product. We provide a wide range of high-quality minerals specifically 

tailored to the needs of athletes. Our team of experts will be happy 

to assist you in selecting the right Mineral Salts for your application. 

No compromises on quality 

sary for many biological processes. Athletes may require up to 70 % 

more Iron than the recommended daily intake (9). About 20 % of 

athletes, especially women and young athletes, are affected by sports 

anemia (10). The consequences of iron deficiency include reduced 

performance, increased fatigue, and prolonged recovery times (3). 

Therefore, monitoring of iron status should be a key aspect of health 

care for athletes. Regular blood tests can help to identify potential 

iron deficiencies early and to take targeted countermeasures. In such 

cases, individualized supplements can help close iron gaps. Iron 

salts by Dr. Paul Lohmann ® are developed under the highest quality 

standards to ensure high bioavailability and suitability for individuals 

with sensitive stomachs. 

Personalization of sports products: a growing trend 

The trend toward personalized nutrition is also gaining momentum in 

sports nutrition. More and more athletes and health-conscious individuals 

are seeking individually tailored mineral supplements that meet 

their training goals and physical needs. Customized products help fill 

nutritional gaps, enhance performance, improve fitness and support 

recovery. By adapting to personal health profiles and activity levels, 

nutrient delivery can be optimized, leading to sustained success. 


Dr. Paul Lohmann GmbH & Co. KGaA 

Hauptstr. 2, 31860 Emmerthal, Germany 

Tel +49 5155 63-0 

sales@lohmann-minerals.com 

www.lohmann-minerals.com 

Photo © : Fotolia/mr.markin 

We manufacture our minerals exclusively in Germany under strict 

quality standards and offer customized solutions tailored to our 

customers’ needs. With our extensive expertise in mineral salt production, 

we help our customers optimize their products and implement 

innovative concepts. Our tailored solutions support the development 

of pioneering products that enable both sports nutrition manufacturers 

and athletes to achieve their goals. 

References 

1. Jahnen-Dechent, W., & Ketteler, M. (2012). Magnesium basics. Clinical kidney journal, 

5(Suppl 1), i3–i14. https://doi.org/10.1093/ndtplus/sfr163 

2. Tarsitano, M. G., Quinzi, F., Folino, K., Greco, F., Oranges, F. P., Cerulli, C., & Emerenziani, 

G. P. (2024). Effects of Magnesium supplementation on muscle soreness in different type 

of physical activities: a systematic review. Journal of translational medicine, 22(1), 629. 

https://doi.org/10.1186/s12967-024-05434-x 

3. Peeling, P., Dawson, B., Goodman, C., Landers, G., & Trinder, D. (2008). Athletic induced 

iron deficiency: new insights into the role of inflammation, cytokines and hormones. European 

journal of applied physiology, 103(4), 381–391. https://doi.org/10.1007/s00421-008- 

0726-6 

4. Sale, C., & Elliott-Sale, K. J. (2019). Nutrition and Athlete Bone Health. Sports medicine 

(Auckland, N.Z.), 49(Suppl 2), 139–151. https://doi.org/10.1007/s40279-019-01161-2 

5. Weaver C, Heaney RP: Calcium. Modern Nutrition in Health and Disease. Edited by Shils 

ME, Olson JA, Shike M, Ross AC. Philadelphia: Lippincott, Williams and Wilkins; 1999:141– 

156. 

6. Molenda, M., & Kolmas, J. (2023). The Role of Zinc in Bone Tissue Health and Regeneration-a 

Review. Biological trace element research, 201(12), 5640–5651. https://doi. 

org/10.1007/s12011-023-03631-1 

7. Hernández-Camacho, J. D., Vicente-García, C., Parsons, D. S., & Navas-Enamorado, I. 

(2020). Zinc at the crossroads of exercise and proteostasis. Redox biology, 35, 101529. 

https://doi.org/10.1016/j.redox.2020.101529 

8. Rowlands, D. S., Kopetschny, B. H., & Badenhorst, C. E. (2022). The Hydrating Effects of 

Hypertonic, Isotonic and Hypotonic Sports Drinks and Waters on Central Hydration During 

Continuous Exercise: A Systematic Meta-Analysis and Perspective. Sports medicine (Auckland, 

N.Z.), 52(2), 349–375. https://doi.org/10.1007/s40279-021-01558-y 

9. Kardasis, W., Naquin, E. R., Garg, R., Arun, T., Gopianand, J. S., Karmakar, E., & Gnana- 

Prakasam, J. P. (2023). The IRONy in Athletic Performance. Nutrients, 15(23), 4945. https:// 

doi.org/10.3390/nu15234945 

10. Keller, K., Friedrich, O., Treiber, J., Quermann, A., & Friedmann-Bette, B. (2024). Iron 

deficiency in athletes: Prevalence and impact on VO2 peak. Nutrition (Burbank, Los Angeles 

County, Calif.), 126, 112516. https://doi.org/10.1016/j.nut.2024.112516. 


Brain health 

Why quality ingredients matter 

The growing need for safety & efficacy assurance amid rising popularity of health supplements 

In today’s fast-paced and competitive 

world, maintaining optimal brain function 

is more than just a health goal—it 

is a lifestyle imperative. Across Europe, 

the growing interest in cognitive performance 

has led to an increased reliance 

on dietary supplements designed 

to improve memory, focus, and overall 

mental performance. While many older 

consumers look to preserve cognitive 

function as part of healthy aging, younger 

consumers, including professionals and 

millennials, are equally keen to sustain 

mental clarity and productivity in an 

increasingly demanding environment. 

Supplements for brain health represent a 

significant segment of the € 45 billion dietary 

supplements industry in Europe 1 . While 

consumer trust is important for any over-thecounter 

product, this is especially critical for 

products intended to support brain health. 

Consumers want to be sure something that 

contributes to their brain will be safe and 

effective. 

According to a survey conducted by the European Food Safety 

Authority (EFSA), a majority of adults aged 50 and older were 

concerned about the purity (76 %), effectiveness (76 %), safety 

(71 %), as well as the thoroughness of government review (73 %) of 

the supplements they purchase 2 . This concern is not surprising, as 

the market for dietary supplements is vast and varied, with products 

ranging from well-researched compounds to those with insufficient 

scientific backing. 

Consumers are naturally drawn to these products because they 

promise improved memory retention, enhanced concentration, and 

increased mental energy. However, the rapid market expansion also 

raises critical concerns regarding product safety, efficacy, and the 

robustness of regulatory oversight. Therefore, trust remains at the 

heart of this booming market, which must be built on a foundation of 

rigorous scientific evidence and strict regulatory compliance. 

Regulatory scrutiny in the European market 

European consumers have long been known for their high standards 

regarding product quality and transparency. In the dietary supplement 

arena, these standards are enforced by a stringent regulatory 

framework. Unlike other markets, the European Union (EU) 

mandates rigorous evaluation of food ingredients and supplements 

before they are made available and sold to the public. 


33

Brain health 

even human breast milk, PQQ is a vitaminlike 

nutrient known for its robust antioxidant 

properties. Its ability to neutralize free radicals 

and reduce oxidative stress is significantly 

more potent than that of well-known 

antioxidants like vitamins C and E. 

Photo © : iStock/PIKSEL 

The European Food Safety Authority (EFSA) plays a central role in 

this process, conducting comprehensive safety assessments for 

novel food ingredients, which include many dietary supplements. 

EFSA’s evaluations ensure that any supplement entering the market 

meets safety criteria, protecting consumers from potentially harmful 

or misleading products. 

Heightened regulatory attention has also been prompted by concerns 

over misleading health claims. Recent years have seen a rise in 

supplements that exaggerate or falsely advertise benefits—sometimes 

claiming to prevent or treat severe conditions like Alzheimer’s 

disease. Such claims, when unsupported by scientific evidence, 

not only undermine consumer trust but can also lead to dangerous 

consequences for public health. As a result, European regulators 

have ramped up their oversight, making it clear that any product 

failing to meet their strict standards will not go to market. 

A 2022 pan-European survey revealed striking consumer attitudes, 

with 78% of respondents identified safety and efficacy as their top 

criteria when choosing dietary supplements and 73 % expressed 

concerns regarding the thoroughness of regulatory reviews and the 

transparency surrounding ingredient sourcing 3 . 

These figures underscore the necessity for supplement manufacturers 

to adhere to the highest safety and efficacy standards. For companies, 

demonstrating scientific validation through clini cal studies and 

obtaining regulatory certifications is not just a legal requirement—it is 

a key factor in winning consumer trust. 

Naturally sourced ingredients for improving brain health 

Among the myriad ingredients marketed for brain health, pyrroloquinoline 

quinone (PQQ) stands out for its promising benefits. Naturally 

occurring in foods such as kiwifruit, spinach, green tea, and 

Oxidative stress, caused by an imbalance 

between free radicals and antioxidants in 

the body, can lead to cellular damage. In the 

brain, this damage is particularly concerning 

because it contributes to the development 

of neurodegenerative diseases, including 

Alzheimer’s disease and dementia. Mitochondria, 

often described as the cell’s 

energy powerhouses, are especially vulnerable 

to oxidative stress. When mitochondria 

are compromised, the resulting energy 

deficit can impair cognitive functions, such 

as memory and learning. 

MGCPQQ ® , developed by Mitsubishi Gas 

Chemical (MGC) in Japan through a proprietary 

fermentation process, harnesses 

the power of PQQ in its naturally sourced 

form. In Europe, this ingredient is marketed 

under the name MGCPQQ. Its formulation 

is designed to not only act as an antioxidant 

but also to enhance mitochondrial health—a 

critical factor for maintaining cognitive function 

as we age. 

Inspiring trust through clinical 

studies 

It is important to note that the studies on 

MGCPQQ, which date back nearly 40 years 

and number over 1,000 studies, have been 

shown to increase levels of mitochondria, 

which is critical for regulating cognitive function, 

memory, as well as energy and mood. 

MGCPQQ has been demonstrated to increase 

a process known as mitochondrial biogenesis, 

which is a part of healthy cell activity 

in which clusters of mitochondria divide and 

multiply. Mitochondrial function begins to 

decline as people age, which leads to impairment 

in brain health as well as the health of 

the heart and other vital organs. In an animal 

study, MGCPQQ was shown to stimulate mitochondrial 

production at a rate of 500 to 1,000 

times higher than other ingredients shown to 

support mitochondrial function 4 . 


Brain health 

In addition to activating mitochondrial 

biogenesis, MGCPQQ has been shown to 

enhance the production of Nerve Growth 

Factor (NGF). Composed of 118 amino acid 

residues, NGF is a protein that helps develop 

and maintain peripheral sympathetic and 

sensory neurons. Studies have shown that 

MGCPQQ may stimulate NGF synthesis and 

secretion, which could play a role in the 

growth and recovery of damaged nerves and 

organs 5 . 

The unique regulatory journey of 

MGCPQQ 

One of the most distinguishing features of 

MGCPQQ in the dietary supplement industry 

is its regulatory approval. In 2018, MGCPQQ 

became the first and only PQQ ingredient 

approved as a Novel Food within the European 

Union. This designation, granted after 

a thorough safety evaluation by the EFSA, 

underscores the ingredient’s compliance 

with the EU’s rigorous safety and quality 

standards. 

The Novel Food approval process in the EU 

is designed to ensure that any new ingredient 

is both safe for consumption and 

effective in delivering its intended benefits. 

For MGCPQQ, this process involved 

extensive scientific research and rigorous 

testing, culminating in a seal of approval that 

provides European consumers with muchneeded 

assurance about its safety profile. 

In addition to EFSA approval, MGCPQQ has 

also obtained certifications from renowned 

global quality assurance programs such as 

Informed-Ingredient. These certifications 

guarantee that every batch of MGCPQQ 

is rigorously tested for contaminants and 

banned substances by World Anti-Doping 

Agency (WADA), which is particularly important 

for athletes and individuals who demand 

the highest quality in their supplements. 

While the market is replete with various forms 

of PQQ supplements, MGCPQQ has established 

itself as the gold standard. Mitsubishi 

Gas Chemical’s proprietary natural fermentation 

process ensures that MGCPQQ is of the highest purity and is 

derived from natural sources. This rigorous process not only maximizes 

the bioavailability of the compound but also ensures that it 

remains free from synthetic additives or contaminants—a critical 

consideration for consumers who are increasingly concerned with 

ingredient transparency. 

Other PQQ alternatives on the market often lack the extensive clini cal 

research and regulatory validation that MGCPQQ boasts. In fact, 

MGCPQQ, known as BioPQQ ® in the U.S., remains the only PQQ 

ingredient that has received New Dietary Ingredient (NDI) notification 

from the U.S. Food and Drug Administration (FDA). The FDA only 

approves about 30 percent of NDI applications further emphasizing 

its status as a well-studied and highly validated supplement ingredient. 

For European consumers who demand scientifically backed, 

high-quality products, MGCPQQ offers unparalleled assurance of 

both safety and efficacy. 

Real-world applications and consumer perspectives 

In recent years, MGCPQQ has been incorporated into a range of 

dietary supplements marketed across Europe. These products are 

designed not only for the general population of all ages seeking 

cognitive support but also for athletes and professionals who require 

enhanced mental and physical performance. Case studies from 

various European markets have demonstrated that consumers taking 

supplements containing MGCPQQ report improvements in mental 

clarity, increased energy levels, and better overall cognitive performance. 

For example, a pilot study conducted in several European countries 

found that individuals supplementing with MGCPQQ over a sixmonth 

period exhibited measurable improvements in both memory 

recall and processing speed compared to a control group 6 . Testimonials 

from consumers, ranging from young people to elderly individuals 

striving to maintain cognitive function, highlight the real-world 

benefits of MGCPQQ. 

Comparative advantages of MGCPQQ 

Photo © : iStock/Fly View Productions 


35

Brain health 

Future perspectives and ongoing research 

The promising benefits of MGCPQQ have sparked continued interest 

among researchers and supplement manufacturers alike. As the 

nutraceutical community further explores the mechanisms behind 

oxidative stress, mitochondrial health, and neuroprotection, additional 

studies are expected to elucidate the full range of benefits 

offered by this powerful ingredient. 

Ongoing clinical trials are examining not only the cognitive benefits 

but also the broader implications of MGCPQQ on metabolic health 

and overall vitality. This research is paving the way for next-generation 

supplements that integrate MGCPQQ with other scientifically validated 

ingredients to create synergistic formulas for enhanced brain 

and body performance. 

The growing emphasis of cognitive function on daily life 

Oftentimes, as a person ages, they can be defined by their memories. 

Without the ability to efficiently process or remember things, 

it can become difficult to function on a daily basis. As such, it is 

essential that people maintain good cognitive health to protect and 

preserve their brain. Making small changes to one’s daily regimen like 

improving vocabulary and working on language skills are also beneficial. 

Engaging in activities such as reading, writing, and participating 

in discussions can enhance cognitive function by challenging the 

brain to process and understand complex information. These activities 

not only keep the brain active but also improve communication 

skills, which are crucial for social interactions and maintaining relationships. 

Physical exercise is another important aspect of cognitive health. 

Regular physical activity increases blood flow to the brain, delivering 

essential nutrients and oxygen that support brain function. Exercise 

also promotes the release of neurotrophic factors, which are proteins 

that aid in the growth and survival of neurons. 

In addition to these lifestyle changes, dietary supplements can play a 

role in supporting cognitive health. By taking supplements containing 

MGCPQQ, which meets regulatory requirements that prove its effectiveness 

and safety, consumers may now be able to decrease the 

acceleration of aging. Healthy mitochondria help maintain cognitive 

function, memory, focus and overall brain health. 

Scientific rigor as the foundation of consumer trust 

In the competitive landscape of dietary supplements, trust is a 

currency that must be earned through scientific validation and regulatory 

transparency. MGCPQQ stands as a prime example of an 

ingredient that meets these high standards. 

Through extensive clinical research, stringent 

quality control measures, and a clear regulatory 

approval pathway in Europe, MGCPQQ 

offers European consumers a safe, effective, 

and scientifically backed solution for maintaining 

cognitive health. 

As the European market for dietary supplements 

continues to evolve, products 

featuring MGCPQQ provide a compelling 

option for those looking to preserve cognitive 

function, promote mitochondrial health, and 

ensure overall brain vitality. For consumers 

seeking a supplement that combines traditional 

wisdom with cutting-edge science, 

MGCPQQ delivers on both fronts. 

To learn more about MGCPQQ and its many 

health benefits, please visit https://www. 

mgcpqq.eu/. 

References 

1 

“Europe Dietary Supplements Market Size, Share Report, 

2030.” Europe Dietary Supplements Market Size, Share 

Report, 2030, www.grandviewresearch.com/industry-analysis/europe-dietary-supplements-market-report. 

Accessed 

14 Mar. 2025. 

2 

European Food Safety Authority. "Food Supplements." 

EFSA, 4 Mar. 2025, www.efsa.europa.eu/en/topics/topic/ 

food-supplements. Accessed 14 Mar. 2025. 

3 

SAFE Food Advocacy Europe “European Consumer Survey”, 

24, Nov. 2024. https://www.safefoodadvocacy.eu/safereleases-a-report-on-a-european-consumer-survey-highlighting-the-need-for-greater-transparency-in-food-labelling/. 

Accessed 14, Mar. 2025. 

4 

Saihara, K., Kamikubo, R., Ikemoto, K., Uchida, K., 

and M. Akagawa, “Pyrroloquinoline Quinone, a Redox- 

Active o-Quinone, Stimulates Mitochondrial Biogenesis 

by Activating the SIRT1/PGC-1α Signaling Pathway.” 

Biochemistry 2017, 56, 50: 6615-6625 (published Nov. 

29, 2017). https://pubs.acs.org/doi/abs/10.1021/acs. 

biochem.7b01185. Accessed 14, Mar. 2025. 

5 

(Murase K., Hattori A., Kohno M. & Hayashi K. (Jul. 1993). 

Stimulation of nerve growth factor synthesis/secretion 

in mouse astroglial cells by coenzymes. Biochem Mol 

Biol Int. 30(40), 615-21. https://www.ncbi.nlm.nih.gov/ 

pubmed/8401318. Accessed 14, Mar. 2025. 

6 

“Europe Dietary Supplements Market Size, Share Report, 

2030.” Europe Dietary Supplements Market Size, Share 

Report, 2030, www.grandviewresearch.com/industry-analysis/europe-dietary-supplements-market-report. 

Accessed 

14 Mar. 2025. 


https://www.mgcpqq.eu/contact/ 


Fibre 

Innovation in acacia gum 

contributes to healthier 

and more sustainable 

gummies 

Harnessing the vast potential of gum acacia, French pioneer 

and expert of natural gums Alland & Robert engages in 

groundbreaking research while collaborating with industrial 

sectors, an approach that prioritizes a virtuous cycle that 

benefits both the planet and humanity. 

Syndeo Gelling ® , a substitute for gelatin 

Alland & Robert has launched Syndeo ® Gelling, a 100 % natural and 

vegan gelling agent to substitute gelatin based on gum acacia and 

other non-vegan gelling agents. Syndeo ® Gelling provides texturizing, 

thickening, stabilizing and binding qualities, offers an alternative for 

vegan health supplements such as gummies and sweet recipes such 

as candies, jellies, or mousses. 

While gelatin provides high elasticity and reduced stickiness, pectin 

helps achieve firmer, stickier textures with little or even no elasticity. 

Syndeo ® Gelling offers both low hardness and higher elasticity than 

pectin, without creating any stickiness. It does not alter the pro ducts’ 

sensory characteristics but preserves the tasting experience and 

feels pleasant in the mouth. 

Finding plant-based substitutes to non-vegan gelling agents can be a 

challenge if you’re looking for that perfect texture and sensory experience. 

If vegan options for plant-based gelling agents such as pectin 

already exist, they do not answer all texturing needs. As an expert in 

natural gums, Alland & Robert has researched a plant-based solution 

that brings excellent stabilizing and texturing properties and helps 

manufacturers find the right balance in formulation. Their research 

shows that vegetal and natural hydrocolloids can be combined to 

create a credible and efficient substitute to gelatin. 

Additionally, being of plant origin, Syndeo ® Gelling can be used to 

improve the image and environmental footprint of confectioneries 

Functional properties to create prebiotic fibre gummies 

Central to Alland & Robert mission is the development of cutting-edge 

gum acacia products that deliver superior functionalities and nutritional 

benefits. All over the world, consumers are not getting enough 

fibre in their daily diets, and at the same time, more and more people 

are affected by digestive discomforts. There is a rise in products 

that answer personalized nutrition goals. Individuals with specific 

health conditions or dietary restrictions may need unique diets to 

manage their conditions effectively, but individuals may simply want 

to improve their digestion and health. Fibre enrichment is essential 

in these products. 

Gum acacia provides high fibre content, lowers consumers’ glycemic 

index and has a positive impact on their gut health. The prebiotic 

effect of acacia is extensively described in literature, evidencing 

that acacia gum increases the numbers and activities of beneficial 

bacteria like bifidobacteria at the expense of more harmful bacteria. 

Alland & Robert recently announced that gum acacia received the 

FODMAP-friendly certification, further cementing its role as a key 

ingredient for health-conscious consumers and those affected by the 

irritable bowel syndrome. 


www.allandetrobert.com 


37


All Photos © : Ladang Sehat 

Cassava flour: 

Gluten-free flour from the tuber 

Cassava, manioc, yuca - the plant with the botanical name 

Manihot esculenta has many names. It is valued for its 

starchy roots and is cultivated in many tropical regions. 

There it is one of the staple foods. Today, the root tuber can 

also be found in our shops from time to time. Cassava flour is 

particularly popular. The slightly sweet-tasting flour has excellent 

baking properties. It is naturally gluten-free and suitable 

for people with coeliac disease. The Import Promotion Desk 

(IPD), a project of the German Federal Ministry for Economic 

Cooperation and Development, supports companies in South 

America, Africa and Asia in bringing their cassava products 

to the European market. “Companies in the IPD programme 

offer both the cassava root and the flour obtained from the 

root,” says Angie Martinez, expert for Sourcing + Markets 

at IPD. “Local processing increases the added value of the 

producers - benefiting both the companies and the people in 

the region.” 

Widespread foodstuff 

The Manihot esculenta plant originally comes from South America. 

The Portuguese colonisers brought the plant to Africa, from where 

it spread to Asia. The plant forms lateral roots underground, which 

develop into root tubers five to ten centimetres 

thick and of varying lengths. The root 

is dark brown on the outside and light to 

reddish on the inside. The cassava plant is 

undemanding, grows well in poor soil and 

can withstand drought. Another advantage: 

cassava can be harvested all year round. In 

many regions, especially in Asia, Central and 

South Africa, cassava with its starchy root 

tubers is the main source of food. The tubers 

are boiled or fried, they are processed into 

flour, which is made into baked goods and 

pasta, and they are also used as the basis for 

alcoholic drinks, such as the cassava beer 

Kashiri. Due to its widespread use, the root 

tuber is also known as the tropical potato. 

Gluten-free baking alternative 

Cassava flour is in demand because the 

gluten-free flour has good baking properties. 

It has a high starch content and a fine 

texture. The powdery cassava flour can be 



used to make soft and elastic doughs that are easy to work with. This 

is due to the flour’s high binding capacity. The good water absorption 

also keeps the baked goods fresh for longer. Thanks to these 

properties, cassava flour can be used as a one-to-one replacement 

for gluten-containing flour in many recipes. The slightly sweet 

flavour goes well with both sweet and savoury recipes. Cassava flour 

is therefore equally suitable for bread, cakes, pastries and pasta. 

“The demand for gluten-free products is increasing on the European 

market”, explains Angie Martinez from the IPD. “In this context, 

interest in cassava flour and foods based on gluten-free flour, such 

as baked goods and pasta, is growing.” 

Difference between tapioca and manioc flour 

Tapioca is also made from the cassava root. It is a flavourless plant 

starch that can be used in the same way as potato or corn starch. 

While tapioca consists only of the extracted starch from the tuber, 

the entire peeled and dried root is used for cassava flour. In this 

way, cassava flour consists of starch, fibre and other nutrients. This 

special composition is the reason for its good baking properties. 

Supplier of dietary fibre 

The flour is not only gluten-free, it also does not raise blood sugar 

levels as much as other starchy foods (low glycaemic index). It 

contains fibre, which supports intestinal health. Due to its high 

carbohydrate content, it is also a good source of energy and low 

in fat. However, cassava flour provides no protein and few vitamins 

and trace elements. Research projects are therefore working 

on cultivating more nutritious cassava roots. The aim is to prevent 

deficiency symptoms in countries where cassava is a staple food. 

Production of cassava flour 

After harvesting, the cassava root must be processed quickly 

because it spoils easily. When the roots are exported, they are 

usually frozen or coated with wax. The roots are poisonous when 

raw. They contain linamarin, which turns into hydrocyanic acid. 

The hydrocyanic acid is destroyed by heating. 

The production of cassava flour differs from region to region. The 

IPD company “Ladang Sehat” from Indonesia produces fermented 

cassava flour. To produce it, the root tubers are cleaned, peeled 

and cut into thin pieces. These pieces are fermented to break 

down the toxin linamarin. Fermentation also improves the availability 

of nutrients and ensures a better texture and digestibility of the 

flour. This process also contributes to the development of flavour 

by making the flour milder and less bitter. Finally, the pieces are 

dried and ground into fine flour. “Ladang Sehat” works closely with 

local farmers from whom the company sources the cassava roots. 

It processes the roots into high-quality cassava flour in modern 

production facilities. In addition to flour, the IPD company also 

produces gluten-free baking mixes, noodles and snacks. 


www.importpromotiondesk.de 


39

Spray drying 

Contract spray drying – a matter of trust 

Spray drying is the method of choice when it comes to gently 

preserving sensitive ingredients while ensuring their easy 

incorporation into a wide range of products. Entrusting valuable 

raw materials to a service provider for further processing 

requires a high level of trust. Uelzena eG is a reliable and 

experienced partner in contract spray drying. With state-ofthe-art 

technology, flexible production capabilities, and the 

highest quality standards, this North German dairy company 

offers customized spray drying solutions for the food and 

infant nutrition industries. 

Extensive technological expertise and years 

of experience 

The choice of spray drying technology and the optimized preparation 

of raw materials significantly influence the desired particle size, which 

can range from fine powders to agglomerated pro ducts. Uelzena’s 

strength lies in its ability to develop tailored drying processes for 

each project, backed by extensive expertise in processing watersoluble 

extracts, aqueous solutions, multi-component mixtures, and 

emulsions. 

At its main production site in Uelzen, 

Germany, Uelzena operates multiple spray 

drying towers of various sizes and configurations, 

enabling the drying of a wide range of 

customer-specific raw materials. To ensure 

precise quality control, the company also 

maintains well-equipped in-house laboratories 

for raw material testing and continuous 

production monitoring. 

Uncompromising quality and hygiene 

standards 

Sophisticated cleaning processes, along 

with dedicated zoning and tower utilization 

concepts, ensure maximum safety throughout 

every stage of the spray drying process. 

Since 2023, the newly established ‘Tower 

12’ spray drying facility has been one of the 

most advanced systems for drying vitamins 


Spray drying 

and minerals under infant high-care conditions. This state-of-the-art 

facility is a self-contained unit, incorporating a high-tech wet mixing 

area and independent packaging lines for aluminum tubular bags, 

ensuring exceptional hygiene and product integrity. 

From raw material to spray-dried product 

Each spray drying project is managed by an interdisciplinary team 

consisting of experts from sales, product development, quality 

management, laboratory, and production. The process begins with 

a detailed project briefing, conducted in close collaboration with the 

customer. This is followed by recipe development and an assessment 

of the optimal processing method. 

Before spray drying, the proper preparation of raw materials is a 

crucial step. Depending on the specific requirements, various technological 

options can be combined within Uelzena’s existing mixing 

lines. 

At the end of the customized drying process, the result is a perfectly 

spray-dried product that meets all agreed specifications and quality 

standards. 


Simone Oeder 

Tel +49 581 806 5870 

Uelzena eG 

Im Neuen Felde 87 

29525 Uelzen, Germany 

www.ingredients.uelzena.com 


41


Photo © : Adobe Stock/Africa Studio 

Sulforaphane, an effective ally 

in PMS management 

Ingood by Olga focuses on Women's Health at Vitafoods Europe with SULFODYNE ® 

For this new edition of Vitafoods Europe, Ingood by Olga 

continues to innovate to offer solutions combining health 

benefits, nutrition, plant-based ingredients, and accessibility. 

Olga’s ingredient division aims to address specific 

niche markets, such as plant-based solutions for sports 

nutrition or women’s health, in line with the hypersegmentation 

trend seen in the nutrition and nutraceutical markets. 

New real-life study on women’s health - SULFODYNE ® 

A new real-life study on 50 women confirms the effectiveness of 

SULFODYNE ® , the unique and authentic form of natural and active 

sulforaphane in managing premenstrual syndrome (PMS). 

Women’s health: A segment in need of solutions 

1 in 2 women suffers from menstrual pain 1 . However, there are no real 

solutions available on the market to address these symptoms. With 8 

out of 10 dietary supplements purchased by women in France, the 

women’s health market is more than an opportunity, it is a segment 

in need of solutions 2 . 

Women’s health is large and covering many 

symptoms or life stages that have long been 

ignored by medical research, many of which 

are linked to an uncontrolled inflammatory 

process. The role of sulforaphane, particularly 

through the activation of Nrf2, is gaining 

interest in managing certain women’s health 

issues, such as premenstrual syndrome 

(PMS). 

Premenstrual syndrome: So common 

and yet so poorly understood 

PMS affects between 30 % and 50 % of 

women 3,4,5 . PMS symptoms are both physical 

(bloating, headaches, pain, etc.) and 

psychological (mood swings, anxiety, 

depression, etc.). They appear 1 to 2 

weeks before menstruation, subside with 

the onset of menstruation, and are cyclical 

and recurrent. 



Recently, a mechanism of action involved 

in PMS development has been identified: 

oxidative stress and chronic inflammation, 

observed through the presence of specific 

biomarkers associated with these two mechanisms 

in women with PMS symptoms 6,7 . 

For instance, a study on women with PMS 

showed a correlation between high levels 

of inflammatory factors (IL-2, IL-4, IL-10, 

and IL-12) and total PMS symptom scores 6 . 

Other inflammatory markers associated with 

migraines, a common PMS symptom, such 

as TNF-α, CRP, and IL-6, are also elevated 

in women with PMS 6 . Another study showed 

that women with PMS had higher levels 

of oxidative stress markers, such as ROS, 

which can damage to neuronal cells and 

cause mood changes 6 . 

SULFODYNE ® : Effective for PMS 

management 

Sulforaphane has well-documented antioxidant 

and anti-inflammatory properties in 

scientific literature, notably through the activation 

of Nrf2, which reduces certain oxidative 

stress markers like ROS, as well as proinflammatory 

parameters, reducing and 

controlling the inflammatory state in various 

in vitro and in vivo models 8,9,10 . 

Recent studies highlight an antidepressant 

and anxiolytic effect of sulforaphane through 

Nrf2 activation 11,12 . Sulforaphane also has 

pain-relieving and anti-inflammatory effects 

in several pain models 13,14,15 . These effects 

are explained by a reduction in markers 

such as IL6, IL-1β, and TNF-α. 

2 x 200 mg per day, 7 days before their periods and during the first 

3 days of menstruation. 

The study results confirm the effectiveness of SULFODYNE ® for 

PMS management, offering a holistic approach 16 : 

– 84 % of women who tested SULFODYNE ® reported a reduction 

in PMS-related discomfort, and more than 9 out of 10 reported 

an improvement in their emotional state and a reduction in pain. 

– 94 % of women found it to fast-acting starting from the first 

cycle. 

– 86 % of women experienced an improvement in their quality of 

life. 

The study also showed a high recommendation rate and strong 

purchase intent: 8 out of 10 women would recommend and buy 

SULFODYNE ® . 

SULFODYNE ® : The unique and authentic active ingredient 

standardized to 5 % stable and active sulforaphane 

Sulforaphane is an isothiocyanate naturally found in cruciferous 

vegetables like broccoli in its precursor and inactive form as glucoraphanin. 

For sulforaphane to be optimally released and absorbed by 

the body, glucoraphanin must be converted into its active form by the 

enzyme myrosinase. 

Various broccoli extracts are available on the market, most containing 

glucoraphanin, often misleadingly labeled as “sulforaphane glucosinolate,” 

which is inactive in this form. Several studies have shown 

that the bioavailability of sulforaphane after ingesting glucoraphanin 

is very low, around 10 %. While adding myrosinase can improve this 

bioavailability, it remains limited, around 30 % 17,18,19 . Myrosinase is 

a sensitive enzyme at acid pH levels that can be inactivated during 

digestion. The use of gastro-resistant capsules slightly improves the 

bioavailability of extracts containing glucoraphanin and myrosinase, 

but it only averages 36 % 17,19 . 

SULFODYNE ® , standardized to 5 % sulforaphane, 

is an excellent candidate for 

modulating PMS symptoms, particularly by 

reducing inflammation through pain-relieving 

and anti-inflammatory effects while providing 

anxiolytic and antidepressant benefits. 

To obtain initial proof of concept, Ingood 

by Olga conducted a real-life study with 

SULFODYNE ® on 50 healthy women aged 

between the ages of 20 and 40 suffering 

from PMS-related symptoms, using a quota 

method in France. Over three cycles, participants 

consumed SULFODYNE ® at a dose of 

Photo © : Adobe Stock/Bitter 


43


SULFODYNE ® is the only broccoli seed extract that contains 

sulforaphane in its free, active, and stable form, requiring no conversion, 

and its 5 % standardization is the highest on the global market. 

Studies confirm that SULFODYNE ® provides a sulforaphane bioavailability 

of 70 % 17,18 , seven times higher. Ingood by Olga aims to educate 

and raise awareness among market players about the importance of 

choosing the right source of sulforaphane to ensure optimal bioavailability 

in the finished product and provide real efficacy to consumers. 

Conclusion 

SULFODYNE ® reduces PMS-related discomfort by acting on both 

on emotional and physical discomforts, in line with evidence already 

established from in vivo studies of pain and depression. It meets 

consumer expectations and contributes to improving the quality of 

life during PMS. Base on consumer feedback evaluated, Ingood by 

Olga intends to continue to study the role of SULFODYNE ® in PMS 

management, particularly its mechanisms of action. 

References 

(1)Étude Ifop, 2021 

(2) Council for responsible nutrition, consumer survey on 

dietary supplements, 2018 

(3)Rezende et al., 2022 

(4)Tiranini & Nappi, 2022 

(5)Modzelewski et al., 2024 

(6)Sultana et al., 2022 

(7)Azlan et al., 2013 

(8)Romeo et al.,2024 

(9)Boddupalli et al., 2012 

(10)Ruhee & Suzuki, 2024 

(11)Martin-de-Saavedra et al., 2013 

(12)Ferreira-Chamorro et al., 2018 

(13)Liu et al., 2020. 

(14)Redondo et al., 2017 

(15)Guadarrama-Enriquez et al., 2023 

(16)SULFODYNE ® real-life study carried out by an independent 

research institute on 50 women in France in 2024. 

(17)Fahey et al., 2015 

(18)Fahey et al., 2016 

(19)Fahey et al., 2019 

Plant-based nutraceuticals and sports nutrition with 

complementary partners 

Ingood by Olga will also present two new concepts with the goal of 

showcasing new uses for its ingredients at Vitafoods and inspiring 

actors in the nutrition and nutraceutical sectors: 

– Good Super Greens: A powder drink made from 7 supergreens, 

including SULFODYNE ® , which offers a concentrate of benefits: 

detox, vitality, concentration, digestive wellness, and immune 

support. Rich in antioxidants and natural vitamins, it provides 

15 mg of sulforaphane per serving. This concept presents a new 

galenic form in which SULFODYNE ® could be integrated, beyond 

capsules and tablets. The concept was formulated with the expertise 

of Nutrisun, Olga’s nutrition division. 

– Good Clear Protein: A clear, vegan protein drink powder formulated 

with our pea protein hydrolysate PEPTIPEA ® , providing 

17.5 g of protein per serving, developed in partnership with Phodé, 

which leveraged its expertise in custom aromatic solutions to mask 

the bitterness of the ingredient. With 40 % of clear protein powder 

launches being vegan, this concept highlights a new application 

of PEPTIPEA ® that allows sports nutrition products to be plantbased 

without compromising on taste or nutritional properties. 

PEPTIPEA ® is a plant-based protein that offers one of the highest 

protein contents on the market. 

Join us at Vitafoods Europe in Barcelona, from May 20 th to 22 nd at 

booth 3G136B in the France Pavilion to discover these ingredients! 


Ingood by Olga 

2 Rue Julien Neveu, 

35530 Noyal-sur-Vilaine, France 

Tel +33 (0)2 99 04 11 11 

www.ingoodbyolga.com 

Photo © : Adobe Stock/Sergey 



Photo © : Adobe Stock/lordn 

Fig. 1: Maintaining bone and joint health is essential for an active life 

Keeping bones and joints healthy for life 

Oliver Wolf 

Bones and joints are crucial for staying 

fit and active throughout life, so it is 

vital to support and maintain their 

health regardless of age. In adolescence, 

good nutrition and physical 

activity help build strong foundations, 

while in adulthood, the maintenance 

of bone density and joint function is a 

priority. Appropriate measures can help 

minimise the risk of age-related conditions 

such as osteoporosis and osteoarthritis. 

Here, collagen peptides can 

play a valuable role throughout all life 

stages. 

Ever-changing needs 

Adolescence is a crucial time for building 

strong bones and healthy joints. During 

this period, a high intake of calcium and 

protein is essential, as peak bone density is 

reached around the age of 25. Sports and 

physical activity also support bone strength and proper joint function, 

yet 1 in 3 schoolchildren in Europe is overweight or obese 1 , 

which is a risk factor for joint-related problems such as osteoarthritis 

in later life 2 . 

When it comes to young adults, it is all about maintaining bone 

mass. That’s because while bone density increases slowly until 

the late-20s, around the age of 35, it begins to decline 3 . This 

means bone remodelling slows down, making a preventive health 

approach increasingly valuable. It is also important to note that in 

this age group in particular, overweight, physical stress and intense 

sporting activity can accelerate wear and tear of joint cartilage tissue 

– leading to joint pain and reduced physical performance. 

For adults aged 30 to 50, protecting against wear and tear becomes 

an even greater priority. It is during this time that the first signs of 

joint deterioration appear, especially for those who are overweight 

or have occupational or sports-related strains. There will also be a 

gradual yet continued reduction in bone density, making osteoporosis 

prevention ever-more important. During this process, bones 

don’t look any different from the outside, yet their internal structure 

starts to become less dense. 


45


By 2050, the United Nations estimates that there will be 2.1 billion 

people aged 60 or older in the world – twice as many as there were 

in 2020. Age-related decline in bone density affects postmenopausal 

women in particular, with one in 3 over the age of 50 predicted to 

suffer an osteoporotic fracture at some point in their life 4 . Yet even 

though the ageing process is the greatest risk factor for both osteoporosis 

and osteoarthritis, the disease is not an inevitable consequence 

of growing old 5 . Bone and joint health can be supported through 

regular moderate physical activity, a balanced diet and supplementation 

with specific collagen peptides. 

a placebo for 24 weeks. 6 In the German arm of the study, it was 

proven that FORTIGEL ® led to a significant reduction in pain as well 

as improved mobility. In order to identify its possible mode of action, 

another study was conducted on patients with mild osteoarthritis of 

the knee joint at the Tufts Medical Center in Boston, USA. 7 Structural 

changes in joint cartilage were evaluated using a special magnetic 

resonance imaging technique called dGEMRIC. While in the placebo 

group a progressive loss of cartilage was observed over the one-year 

study period, the group receiving FORTIGEL ® showed significantly 

reduced degeneration of the extracellular cartilage matrix. 

Why collagen? 

While collagen has been successfully used for years in topical 

beauty and personal care products such as body lotions and face 

cream, recent scientific evidence confirms that the highest efficacy 

is achieved when collagen is ingested orally. As a key component 

of bones and joints, collagen makes up 95 per cent of the human 

body’s bone matrix; as such, it is essential for bone health as it helps 

to prevent brittleness and breakage. Collagen is also a core component 

of the matrix that gives structure to cartilage, which is vital for 

flexible, properly functioning joints. 

However, collagen supplementation should not be considered a 

one size fits all solution. Different collagen peptides offer enhanced 

benefits for specific areas of the body. Research shows that GELITA 

Bioactive Collagen Peptides (BCP ® ) are optimised to maximise the 

stimulatory effects on certain cells in the body, and that the level of 

stimulation is different for varying collagen peptide compositions. 

Healthy joints with FORTIGEL ® 

To support joint health and prevent cartilage-related joint pain, GELITA 

has developed FORTIGEL ® - specific BCP ® optimised and scientifically 

proven to stimulate joint cartilage regeneration and promote 

measurable growth of cartilage tissue. Its considerable advantage 

over other ingredients typically offered to improve joint conditions is 

that it tackles the cause of the problem rather than just the symptoms. 

Once inside the body, FORTIGEL ® accumulates in the joint 

cartilage, where it promotes the production of collagen and proteoglycans 

– the two major components of cartilage dry mass. It also 

combats progressive degeneration of cartilage tissue. 

FORTIGEL ® has been tested in more than 20 clinical and pre-clinical 

studies, primarily conducted among patients of various age groups 

with mild to moderate osteoarthritis of the knee. Preclinical studies 

substantiate the observation that orally ingested FORTIGEL ® has a 

stimulating effect on biosynthesis of the extracellular cartilage matrix. 

For example, in a randomised, double-blind, placebo-controlled study 

carried out in 19 medical centres in the USA, the UK and Germany, 

389 patients aged between 45 and 80 with diagnosed osteo arthritis 

of the knee joint were given either 10 g of FORTIGEL ® per day or 

Fig. 2: To support joint health and prevent cartilage-related joint pain, 

GELITA has developed FORTIGEL ® 

At Penn State University (USA, 2008), 147 athletes with a mean age 

of 20, all of whom were experiencing activity-related joint pain, were 

recruited for a study. They were subdivided into two groups – one 

of which took FORTIGEL ® as a nutritional supplement and a control 

group that took a placebo for 24 weeks. In this prospective, randomized, 

double-blind, placebo-controlled study, a statistically significant 

difference of pain perception between treatment and control 

groups was observed. When utilising alternative therapies such as 

hydrotherapy, massage and ice and heat packs, there was a clear-cut 

difference between the treatment and the placebo group in favour of 

the FORTIGEL ® group. 

Why is collagen vital for bone health? 

The human bone matrix consists of 70 % inorganic minerals, such as 

calcium and phosphorus, which are responsible for bone strength. 

Organic matter with collagen fibres makes up a further 20 % and the 

remaining 10 % is water. 



Collagen forms the scaffold for bone mineralisation, allowing calcium 

and other minerals to be deposited. However, if the bone matrix is 

weak, there are not enough binding sites for calcium, resulting in a 

lack of bone density. A stable collagen structure is therefore vital for 

strong and healthy bones. Supplementation can help achieve this by 

improving bone density and elasticity. FORTIBONE ® stimulates osteoblast 

activity to increase the production of extracellular bone matrix. 

In addition, it regulates the degenerative processes that affect bones 

by reducing osteoclast-based protease production. Hence, it supplies 

the body with the basic components needed for a strong and stable 

bone structure, supporting overall stability and flexibility. 

Numerous studies have investigated the impact of supplementation 

of FORTIBONE ® collagen peptides on bone density. For example, 

a study looking at bone mineral density (BMD) in postmenopausal 

women with osteopenia or milder forms of osteoporosis found that 

a daily dose of 5 g of FORTIBONE ® for 12 months had an anabolic 

effect, with a pronounced increase in BMD after supplementation. 8 

There was also an escalation of bone formation, but no changes 

in bone degradation markers. Such data supports the assumption 

that FORTIBONE ® is an innovative ingredient for the formulation of 

pro ducts that counteract bone degeneration and support optimal 

bone health. 

Technological characteristics 

Besides their nutritional benefits, GELITA’s BCP ® offer many technological 

advantages for manufacturers. They are easy to combine with 

vitamins, minerals and other nutrients, and show excellent cold-water 

solubility. Being neutral in taste and colour, they have no negative 

impact on the sensory profile of end products. They also have high 

heat and acid stability as well as low viscosity, and there is no precipitation 

or clumping during processing. 

As well as being free from fat and cholesterol, Bioactive Collagen 

Peptides are completely natural, which makes them ideal for clean 

label formulations. They can enhance a range of applications that 

appeal to different age and target groups, including gummies, bars, 

shakes, shots, functional foods and beverages, as well as dietary 

supplements like capsules and powders. 

In a nutshell 

Regardless of age, maintaining bone and joint health is essential 

for an active life. Collagen peptides can offer valuable support at all 

life stages by supporting and strengthening bone health, protecting 

joints and promoting mobility. With their technological advantages, 

collagen peptides offer manufacturers many opportunities to develop 

consumer-centric products tailored to the needs of different age 

groups. 

Fig. 3: A stable collagen structure is vital for strong and healthy bones. 

References 

1 

Source: Childhood obesity in European Region remains high: new WHO report presents 

latest country data 

2 

Source: Osteoarthritis: Role of Body Weight in Osteoarthritis - Weight Management 

3 

Source: Osteoporosis: Age and Bone Strength 

4 

Source: How_fragile_is_her_future.pdf 

5 

Source: Why is Osteoarthritis an Age-Related Disease? - PMC 

6 

Moskowitz RW, 2000: Role of collagen hydrolysate in bone and joint disease. Semin 

Arthritis Rheum, 30, 87 – 99. 

7 

McAlindon TE, et al.: Change in knee osteoarthritis cartilage detected by delayed gadolinium 

enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a 

pilot randomized controlled trial. Osteoarthritis and Cartilage (2011) Apr;19(4):399-405. 

8 

Daniel König D, Oesser S, Scharla S, Zdzieblik D, Albert Gollhofer A (2018) Specific Collagen 

Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women – A 

Randomized Controlled Study. Nutrients 2018, 10, 97; doi:10.3390/nu10010097. 


Oliver Wolf 

Global Product Promotion 

GELITA AG 

Oliver.Wolf@gelita.com 

www.gelita.com 


47

Heart health 

Heart-healthy snacking: Science-backed 

strategies for cardiometabolic health 

According to the World Health Organization (WHO) cardiovascular 

diseases (CVDs) remain the leading cause of 

mortality worldwide, contributing to millions of deaths each 

year. While genetics play a role, lifestyle factors, particularly 

nutrition, are among the most powerful tools in preventing 

and managing heart disease. Emerging research underscores 

the importance of dietary patterns rather than isolated nutrients, 

but specific foods, such as almonds, have been shown 

to offer unique benefits for heart health, as discussed in a 

new peer-reviewed publication 1 . 

The role of snacking in cardiovascular health 

Snacking is an integral part of modern dietary habits, but its impact 

on cardiometabolic health can vary significantly. When it comes to 

snacking choices, the grocery aisles hold many options, but nutrientdense 

snacks can help regulate blood pressure, cholesterol, and 

body weight when chosen strategically. 

Nutrients that support heart health 

A heart-healthy diet should emphasize foods rich in: 

– Unsaturated fats: Monounsaturated and polyunsaturated fats, 

found in almonds, avocados, and olive oil, help lower LDL cholesterol 

and improve the lipid profile. 

– Dietary fiber: Soluble fiber, found in 

almonds, oats, and legumes, binds cholesterol 

in the gut, reducing absorption and 

improving glycemic control. 

– Antioxidants: Polyphenols and vitamins 

such as vitamin E combat oxidative stress, 

a key factor in the development of atherosclerosis. 

– Magnesium and Potassium: 

These minerals help regulate blood 

pressure by promoting vasodilation and 

reducing arterial stiffness. 

By incorporating these nutrients into daily 

snacks, individuals can actively support their 

cardiovascular system. 

Almonds: An evidence-based snack 

for heart health 

A growing body of scientific research supports 

almonds as a beneficial food for heart health. 

In line with this, a recent consensus paper 1 

published in “Current Developments in 

Nutrition” reviewed over 200 peer-reviewed 


Heart health 

studies and concluded that regular almond 

consumption offers multiple cardiometabolic 

benefits. Clinical research indicates 

that almonds contribute to a reduction in 

LDL cholesterol, with meta-analyses showing 

a decrease of approximately 5 %, a significant 

figure considering even minor reductions 

can lower heart disease risk. Additionally, 

studies report a modest but meaningful 

decrease in diastolic blood pressure (0.17– 

1.3 mmHg), which, when combined with 

other dietary interventions, may contribute 

to overall cardiovascular risk reduction. 

Contrary to concerns about calorie density, 

regular almond consumption is not associated 

with weight gain. Some studies 

even suggest that almonds may promote 

weight loss due to their satiating properties. 

2 Prelimi nary findings also suggest that 

almonds support gut microbiota diversity, 

which plays a role in metabolic health and 

inflammation control. A single 30 g serving of 

almonds provides 6 g of protein, 4 g of fiber, 

and 13 g of unsaturated fats, making them 

an ideal component of a heart-friendly diet. 

Practical strategies for integrating 

heart-healthy snacks 

Given the increasing awareness of heart 

health, consumers are actively seeking 

convenient and nutritious snack options. 

Several evidence-based snack ideas align 

with cardioprotective principles. Almonds 

paired with dark chocolate (with at least 70 % 

cocoa) create a synergistic effect where the 

flavonoids in cocoa enhance vascular function alongside the unsaturated 

fats in almonds. The nutrients in Greek yogurt, almonds and 

berries provide probiotics for gut health, polyphenols for antioxidant 

support, and healthy fats for cardiovascular benefits. Whole-grain 

crackers with almond butter deliver fiber, protein, and monounsaturated 

fats, which help stabilize blood sugar levels and reduce cholesterol 

absorption. Oatmeal with almonds and cinnamon combines the 

cholesterol-lowering effects of beta-glucans in oats with the satiety 

and healthy fat profile of almonds. Smoothies incorporating almonds, 

berries, and leafy greens offer a nutrient-packed option rich in antioxidants, 

healthy fats, and fiber that can improve endothelial function 

and combat inflammation. 

While incorporating heart-healthy snacks, it is also important to 

avoid common pitfalls. Excess sodium, prevalent in many processed 

snacks, can contribute to hypertension. Added sugars should be 

minimized to improve lipid profiles and insulin sensitivity. Replacing 

saturated and trans fats with unsaturated alternatives can significantly 

reduce cardiovascular risk. 

Almond trends 2025: The future of heart-healthy snacking 

As the functional food industry expands, consumer interest in 

almonds and heart-health benefits continues to grow as shown in a 

new Tastewise Report on Almond Trends in 2025. Tastewise is a data 

platform that uses artificial intelligence to analyze current trends and 

consumer preferences in the category of taste and food. The Report 

shows that there has been a significant rise in online discussions 

regarding almonds’ detoxifying properties, with a 426 % increase. 

Mentions of almonds for immune support have grown by 216 %, 

while recognition of almonds as a source of healthy fats has increased 

by 148 %. Additionally, there has been a 74 % growth in associations 

between almonds and antioxidants. 


49

Heart health 

markets and health food stores, reflecting 

consumers’ increasing preference for 

sustainable, nutrient-rich ingredients in food 

formulation. 

Why almonds align with the future of 

cardiometabolic wellness 

Innovation in almond-based products is also on the rise. Almond flour 

and almond butter are increasingly used as gluten-free alternatives in 

baking and spreads. Plant-based almond beverages, such as almond 

milk, remain a top dairy alternative and are now fortified with additional 

heart-healthy nutrients. Functional almond snacks, including 

energy bars, granola mixes, and high-protein almond-based products, 

are gaining popularity. Almonds are also being incorporated 

into Mediterranean, Middle Eastern, and Asian-inspired dishes to 

enhance both flavor and health benefits. 

Impact on retail and foodservice 

The presence of almond-based dishes in restaurant menus has 

grown, with 4.58 % 3 now featuring these options. There is also a 

growing retail demand for almond-inclusive product lines in super- 


https://www.almonds.com 

Almonds not only provide essential nutrients 

but also align with consumer preferences for 

sustainable, functional foods. The growing 

trend toward plant-based and whole-food 

snacking further positions almonds as a 

key player in the future of wellness-driven 

nutrition. The almond industry has made 

significant strides in sustainability, reducing 

water usage and implementing eco-friendly 

farming practices . Many almond producers 

now prioritize regenerative agriculture, 

further reinforcing their appeal among environmentally 

conscious consumers. 

References 

1 

Paula R Trumbo, Jamy Ard, France Bellisle, Adam 

Drewnowski, Jack A Gilbert, Ronald Kleinman, Anoop 

Misra, John Sievenpiper, Maha Tahiri, Karol E Watson, 

James Hill, Perspective: Current Scientific Evidence and 

Research Strategies in the Role of Almonds in Cardiometabolic 

Health, Current Developments in Nutrition, 

Volume 9, Issue 1, 2025,104516, https://doi.org/10.1016/j. 

cdnut.2024.104516. 

2 

Berryman CE, Kris-Etherton PM, et al. Effects of Daily 

Almond Consumption on Cardiometabolic Risk and 

Abdominal Adiposity in Healthy Adults with Elevated LDL- 

Cholesterol: A Randomized Controlled Trial. Journal of the 

Ameri can Heart Association. 2015;4:e000993. 

3 

Tastewise Report, Almond Trends 2025 

4 

https://www.almonds.com/sites/default/files/2024-06/ 

ES_Infographic_Digital.pdf 

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