Newsletter_06-2025_EN

EN 06/25

New SynTiso line concept

revolutionizes liquid

pharmaceutical filling

TITEL

New SynTiso line concept

revolutionizes liquid


– Joint development with partners from the pharmaceutical industry

– The highest output in the market: up to 600 containers per minute

– Significantly reduced contamination risk thanks to full automation and contactless, suspended transport

At Pharmatag 2025 in Crailsheim, Syntegon presented a new line

concept for liquid pharmaceuticals. SynTiso was developed in collaboration

with two partners from the pharmaceutical industry and

addresses the current challenges of pharmaceutical manufacturers

regarding high performance and availability as well as maximum

product yield and minimal operator intervention. “As a strategic

partner to the pharmaceutical industry, we will revolutionize filling

operations together with our customers,” says Stephan März, Executive

VP Pharma Liquid at Syntegon.

Fully automated and Annex 1-compliant

Thanks to the gloveless isolator, pharmaceutical manufacturers can

automate their processes and minimize human intervention. “But

we go one step further with SynTiso: the robots are generally located

as far away from the process as possible and are only used for aseptic

setup and as needed,” explains product manager Markus Heinz.

This provides customers with an Annex 1-compliant solution including

the First Air principle, which allows air to circulate freely. “The

position of the robots also minimizes particles in the aseptic area,

which in turn significantly reduces the risk of contamination,” says

Heinz. Real-time monitoring of germs and particles also eliminates

the need to exchange settle plates.

www.reinraum.de | www.cleanroom-online.com NEWSLETTER | Edition EN 06-2025

page 2/34

Innovative, contactless transport

The new contactless, suspended transport

generates no particles and facilitates cleaning

and maintenance, even with highly

potent pharmaceuticals such as oncological

drugs, among other things thanks to a

smaller number of components within the

isolator. The system ensures faster aseptic

transport and up to 50 percent shorter batch

changeovers in a smaller space. With 100

percent in-process control (IPC), SynTiso

can process up to 600 syringes, vials, or cartridges

per minute — a speed never before

seen on the market. “This is an important

factor, for example in vaccine production,”

Heinz explains. “Of course, SynTiso is also

suitable for filling the increasingly popular

ready-to-use (RTU) containers.”

Working together to advance the vision

“As a strategic partner to our customers, we

once again focused on joint development —

and have integrated pharmaceutical processes

into the system design of SynTiso right

from the start,” Stephan März emphasizes.

“The result is impressive: this line concept

brings us a big step forward toward our vision

of a virtually empty isolator, which will

deliver significantly greater flexibility and

faster availability.”

JUNE 2025

Dear cleanroom professionals,

How fast time passes. It‘s already June and at the end

of this month the first half of the year will be over.

How fast time passes. In this context, I realized

that Reinraum Online began to establish itself as a

communication platform for the cleanroom industry

33 years ago.

Nowhere else are news, facts and knowledge presented

more up-to-date and clearly presented than here:

Online on the Internet, in the newsletter and in

the Newsflash and in print in the Yearbook and the

Book of Experts.

Our offer: You too can use Reinraum Online for

your professional communication!

In the June newsletter you will find the following

articles, among others:

> New SynTiso line concept revolutionizes liquid


> Positioning wafers with micrometer precision

for PECVD Coating

> It all depends on the right filling System

> Comprehensive robot solutions for today‘s

electronics manufacturing

> From raw material processing to recycling:

New approaches in battery production

> Syntegon Pharmatag 2025:

Enabling collaborative success

> Swiss Biotech Report 2025

> Clean solutions for the pharmaceutical

and biotechnology industries

> . . .

Syntegon Technology GmbH

Blaufelder Straße 45

74654 Crailsheim

Deutschland

Telefon: +49 7951 4020

eMail: packaging-ph@syntegon.com

Internet: http://www.syntegon.com

With kind regards

Reinhold Schuster


page 3/34

Due to the limited space available, the robot was mounted on the ceiling of the

loading area of the coating system and has a reach of 1,000 millimeters.

(Photo: AZUR SPACE Solar Power)

Vision-assisted robotics for handling delicate products with high accuracy

Positioning wafers with micrometer

precision for PECVD coating

For loading and unloading workpiece carriers containing

wafers of different sizes in an automated process prior to

PECVD coating, acp systems has developed a robotic solution

aided by image processing for a leading manufacturer

of space solar technology. It ensures that the specified positioning

accuracy of +/- 0.1 mm in the nests of the workpiece

carriers is met and that both the manufacturing tolerances

of the carriers and their shrinkage caused by cooling during

loading are compensated for.

Azur Space Solar Power GmbH, which is based in Heilbronn, is one

of the world’s leading companies that develops and produces highly

efficient multi-junction solar cells for space and terrestrial concentrator

systems (CPV). All solar cells are based on the latest triple and

quadruple junction technology, in which the layers are built up on a

germanium substrate.

Automating the challenging loading and unloading process

During the production process, the 4-, 6- and 8- inch (100, 150 and

200 mm) diameter wafers undergo a PECVD process (plasma-enhanced

chemical vapor deposition) in systems from Singulus Technologies

AG. The solar cells are supplied in cassettes, removed from

them and placed in the nests of special carbon fiber workpiece carriers,

which are just a few hundred micrometers larger. Depending

on the cell size, the 1000 x 600 mm carriers can hold four, nine or 16

wafers. To avoid collisions, a positioning accuracy of +/- 0.1 mm must

be reliably met when loading the workpiece carriers. After being coated

on one or both sides, the solar cells must then be placed back into

cassettes.

Azur Space wanted to automate this previously time-consuming

and cost-intensive manual process using suction pipettes. The position

of the solar wafers with flats in the cassettes can deviate by +/- 5

degrees and +/- 3 mm and the gripping points are precisely defined,

making this quite a challenge. In addition, the production-related

tolerances of the carriers have to be compensated for, as must the

shrinkage caused by cooling. This is due to the falling temperature of

the workpiece carriers, which come out of the coating process at up

to 350 °C and cool down during unloading and loading.

Positioning accuracy ensured with illuminated alignment table

and image processing

To realize this task, automation specialist acp systems AG developed

an intelligent, vision-assisted handling solution with an industrial

robot. Due to the limited space available, this was mounted on the

ceiling of the loading area of the coating system and has a reach of

1,000 millimeters. The Scara robot is equipped with a special flat va-


page 4/34

cuum gripper system that can be quickly exchanged to handle wafers

of different sizes.

The robot takes out the wafer from the cassette and places it on

a backlit alignment table. A camera system with a 12-megapixel camera

is located above the table at a working distance of 680 mm. It

detects the exact position of the wafer and sends this information to

the Cognex Vision Pro software. Based on this, the software calculates

the position and angle of compensation required to insert the

wafer into the carrier nest and transmits the data to the robot controller.

Any distortions in the camera system were compensated for

during commissioning by calibrating it with a checker plate.

In order to overcome the manufacturing tolerances of the carriers

and the shrinkage caused by cooling, each workpiece carrier is

first centered by pulling it against a stop and indexing it. This allows

the coordinate zero point of all carriers in the handling system to be

reproducibly defined. Furthermore, to compensate for manufacturing

tolerances, all carriers were accurately measured beforehand in

their cold, new state and each was given a data matrix code for identification.

This code is used to store relevant data in the controller so

that the position tolerances of the carrier nests can be calculated and

compensated for.

To compensate for the thermal shrinkage caused by the workpiece

carriers cooling down, a fiducial mark was first placed in the

corner of each carrier opposite the coordinate zero point, and this

was also accurately measured precisely when cold. A second camera

system is located above this, enabling the offset of the fiducial mark

compared to the cold state to be determined. The software uses this

information to calculate the compensation needed to set down the

wafer accurately in position. This process is repeated for each wafer

to be inserted.

Flipping station for turning the wafers

acp systems also integrated a flipping station for turning the solar

cells so that they can be coated on both sides. This receives the

corresponding wafers one by one from the robot and grips them at

defined points with vacuum suction dots. After the wafer has been

rotated by 180 degrees, the robot gripper picks it up again and transfers

it to the alignment table.

The camera system located above the backlit alignment table

detects the exact position of the wafer and sends this information to

the software. Based on this, the software calculates the position and

angle of compensation required to insert the wafer into the carrier nest.


The flat vacuum gripping system, which can be quickly exchanged

for the different sized wafers, maintains the specified positioning

accuracy of +/- 0.1 mm when loading the workpiece carriers.


Integrated quality control

Before the coated solar cells are placed back into the cassettes, a

final quality check is carried out by the camera system on the alignment

table. This checks whether the edges of the wafers are free of

damage.

The vision-assisted robotic solution described above ensures

that the extremely delicate solar wafers are handled with high

precision and care. This is demonstrated above all by the fact that

there have been no handling-related wafer breakages since commissioning.

Overall, replacing manual handling with a fully automated

system has resulted in significantly improved productivity and efficiency.

For turning the solar cells so that they can be coated on both sides there

is a flipping station integrated. (Photo: AZUR SPACE Solar Power)

acp systems AG

Berblingerstraße 8

D 71254 Ditzingen

Telefon: +49 7156 480140

eMail: info@acp-systems.com

Internet: http://acp-systems.com

Before the coated solar cells are placed back into the cassettes

the camera system checks whether the edges of the wafers are

free of damage. (Photo: AZUR SPACE Solar Power)


page 5/34

Efficient filling of liquid pharmaceuticals

Syntegon‘s experts carry out extensive tests with the

real product in the company‘s own laboratories.

It all depends on the right filling system

Author: Sarah Springer

From highly potent to viscous and liquid drugs, pharmaceutical

producers and contract manufacturers must fill numerous

medicines and suspensions into a wide variety of

containers. Choosing the right filling system is crucial for

efficient and safe processes. This requires a partner with a

broad portfolio who is capable of accurately adapting filling

systems to the respective products.

The range of marketed pharmaceuticals is greater than ever before.

On the one hand, demand for blockbusters and generics remains

unchanged. Pharmaceuticals such as blood thinners, painkillers and

insulin have become a mainstay in pharmacies. New developments

such as the incretin mimetic semaglutide, which has become very

popular in obesity and diabetes treatment in recent years, are significantly

expanding the number of available drugs.

On the other hand, the rise of advanced therapy medicinal products

(ATMPs) such as cell and gene therapies as well as biotechnologically

processed tissue products underpins the industry’s continued

diversification. Highly individualized therapeutic options pose

new challenges for the filling of small and very small batches. But

which filling system is the right one for which product?

The peristaltic pump can be operated single-handedly,

as it does not require any format parts.

The easy-to-use, highly flexible rotary valve piston pump with

its volumetric operating principle ensures high dosing accuracy.


page 6/34

Peristaltic pump: particularly suitable for single-use applications

To date, the rolling diaphragm pump has primarily been used

in North America for filling cost-intensive biotech products.

The peristaltic pump is a well-established and widely used technology

on the market. As it does not require any format parts apart

from the tubes, it can be operated single-handedly. Its ease of use,

gentle product handling, and precise dosing make the pump an ideal

choice for shear-sensitive products and filling operations in barrier

systems according to EU GMP Annex 1. The peristaltic pump can be

permanently installed or applied as single-use system, since the tube

and needle can be inserted and replaced very easily. In addition, the

peristaltic pump achieves maximum product yields, hence meeting

an essential requirement for the filling of high-priced biopharmaceuticals

and very small quantities.

Rotary valve piston pump: simple, cost-effective, and robust

The extremely flexible rotary valve piston pump is even more widespread

than the peristaltic pump. As a simple, cost-effective, and

robust filling technology, pharmaceutical manufacturing companies

often use them for several applications. The volumetric operating

principle ensures high dosing accuracy. In contrast to the peristaltic

pump, the rotary valve piston pump can also process aqueous and

highly viscous liquids such as Botox or hyaluronic acid. In addition

to the stainless-steel version, the pump is available as a ceramic version

for extreme temperature ranges, allowing to gently fill hot and

abrasive products.

Rolling diaphragm pump: from the U.S. to Europe

The time-pressure filling system enables precise and gentle

filling thanks to its space-saving design and simple format changes.

The rolling diaphragm pump perfectly lends itself to the filling of

sensitive biopharmaceuticals. It combines the advantages of the peristaltic

and rotary valve piston pump: the absence of shear contours

enables gentle product handling, while the volumetric filling system

ensures precise dosing. The innovative concept uses a flexible

diaphragm to transfer the product gently through the piston and

the pump body. To date, this technology has primarily been used in

North America to fill cost-intensive biotech products. It is now also

available in Europe in various sizes for between two and 250 milliliters.

In addition to the CIP/SIP and stainless-steel versions, the

single-use option offers major advantages.

Time-pressure filling system: compact with few moving parts

Pharmaceutical manufacturers who require high output and a large

number of filling stations including barrier systems can rely on the time-pressure

filling system – especially for high volumes of insulin or

new semaglutide products in cartridges. The space-saving design of

the filling system ensures good accessibility and easy format changes.

It enables precise and gentle product filling, not least due to a

reduced number of moving mechanical parts. The control algorithms

keep product loss low and are as intelligent as the mechanics are

simple. Although the time-pressure filling system is not recommended

for viscous products, it reliably processes shear-sensitive drugs.

Mass-flow system for hot and cold filling

Highly developed sensor technology allows the

mass flow system to handle hot and cold filling.

The mass-flow system operates in a similar way. It uses the same

components as the time-pressure filling system and offers a viable

solution for special applications such as highly potent cytostatics.

With one major difference: the filling process is controlled by a flow

meter instead of time pressure. A mass flow sensor operating according

to the Coriolis principle in each filling line ensures immediate


page 7/34

100% in-process control (IPC) and precise filling processes. Thanks

to this highly developed sensor technology, the system can handle

demanding applications such as hot and cold filling and is the preferred

choice for X-ray products.

Combi filling: several filling stations on one machine

Growing numbers of pharmaceutical liquids and increasingly frequent

product changes pose new challenges to pharmaceutical

producers and contract manufacturers alike. How can different products

with different properties be filled efficiently and in a spacesaving

manner? The answer is combi filling stations: thanks to the

combination of several filling systems on one machine, they ensure

maximum flexibility and allow to adapt production line set-ups at

any time. Depending on the design, the solutions can accommodate

up to four common filling systems, which can be used in the stainless-steel

version and for single-use systems that process different

containers.

Smart Pump: making filling systems intelligent

As with all production processes, transparency is becoming increasingly

important during filling. Latest developments and additional

functionalities ensure that pump-specific parameters such as cleaning

status, serial numbers, and correction values are transmitted to

the filling machine using a reader and state-of-the-art RFID technology.

Operators can read the visualized data on the machine’s HMI

conveniently and reliably. This way, new digital solutions contribute

to maximum precision and transparency in the filling process, opening

new possibilities for predictive maintenance.

Functionalities for maximum product yield

Other functionalities relate to increasingly expensive, specialized

medicines such as blood plasma derivatives. Manufacturers of those

products focus on high product yields. Micro-dosing, for example,

allows containers to be weighed and filled very precisely during

start-up and shutdown. In high-performance machines, the last five

percent of the product can be dosed even more precisely and within

narrower tolerance limits using a very small filling needle. This allows

manufacturers to achieve maximum filling accuracy even during fast

filling processes. Moreover, product losses can be prevented: if a

container is underfilled, the process is stopped briefly, and the filling

station moves back to the filling point. This way, no container is rejected

due to inaccurate filling volumes.

Support for the right choice

New digital solutions boost precision and transparency in the

filling process, opening new possibilities for predictive maintenance.

Given the wide range of possibilities, the most pressing question

remains which filling system to use for a particular product. This is

where system solution suppliers such as Syntegon can provide support

with comprehensive service and sound technological and pharmaceutical

expertise. Syntegon’s laboratories offer pharmaceutical

companies extensive trial options with their real products. Services

include the specific testing of selected filling systems, the siliconization

of products and stopper tests for syringes, as well as the comparative

testing of different filling systems.

In case of portfolio expansions, for example for new medicines

or modified output quantities, the best retrofitting or converting options

for filling systems can be identified and implemented. Possible

changes include switching from stainless steel to ceramic or to

a combi filling station with a single-use filling system including a

pump trolley. In addition, there is a wide variety of format sets as well

as a comprehensive range of accessories for the various filling systems

available to retrofit an existing system. Syntegon‘s experts work

closely with customers to find solutions for all product characteristics.

Because one thing is certain: choosing the right filling system is

crucial for efficient liquid pharmaceutical filling.

Combi filling stations offer maximum flexibility and make production

lines adaptable at any time.



D 74654 Crailsheim

Telefon: +49 7951 4020




page 8/34

Comprehensive robot solutions

for today‘s electronics manufacturing

From the manufacture of semiconductors

and chips to the use of industrial robots

in electronics production. Mitsubishi

Electric covers the entire value chain.

(Source: Mitsubishi Electric Europe B.V.)

Precision, flexibility and efficiency are more important than ever in electronics manufacturing. And digitalization is playing

an increasingly important role. Instead of a one-size-fits-all solution, Mitsubishi Electric offers a wide range of innovative

approaches tailored to specific production requirements. Whether it is sensitive PCB production, PCB assembly, electronic

component assembly or quality control - each application requires a tailor-made solution.

In modern electronics production, processes such as through-hole

technology (THT) and printed circuit board (PCB) assembly are indispensable.

The compact MELFA robots from Mitsubishi Electric

more than meet the high production requirements. Highest precision

(up to ±0.02 mm repeatability), ESD certification (IEC 61340-

5-1) for safe operation in EPAs (Electrostatic Protected Areas) and

optional clean room certification (ISO class) by Fraunhofer IPA guarantee

product quality from component placement to quality control.

ESD certification

Protection against electrostatic discharge (ESD) is critical in electronics

manufacturing, as even the smallest voltages can cause irreparable

damage to sensitive components. To ensure maximum

safety and product quality, all MELFA robots from Mitsubishi Electric

are ESD compliant and comply with the IEC 61340-5-1:2016 and

ANSI/ESD S20.20:2014 standards. This allows them to be used reliably

in ESD-protected areas, such as automated printed circuit board

production. This includes tasks such as assembly and inspection of

connectors and/or other components, functional and in-circuit testing,

reflow soldering, AOI (Automated Optical Inspection) and packaging

of electronic circuit boards and SMD assembly.

Clean room robots with ISO classification

These MELFA robots also have clean room certification (ISO class)

issued by the Fraunhofer IPA Institute, the certification body for this

type of regulation. This certification is highly sought after in the electronics

industry, where clean room testing is often performed with

forced air circulation to prevent microparticles from coming into

contact with the product and contaminating it.

AI as a driving force

Collision avoidance for safe motion, AI-assisted precision force

sensors for delicate assembly tasks, cooperative control for seamless

integration with existing systems, and intelligent temperature compensation

to maintain maximum accuracy under changing environmental

conditions. These are just some of the useful features that are

important in electronics manufacturing.

The robots are equipped with many intelligent algorithms that

enable continuous process optimization and preventive maintenance.

This significantly reduces downtime in the automated placement

and assembly of electronic components.

Innovative approaches for a demanding market

With its versatile solutions, Mitsubishi Electric serves the entire

electronics manufacturing industry - and not just with a broad portfolio

of SCARA, jointed-arm and collaborative robots. The powerful

drive and control systems also optimize processes along the entire

value chain - from precision PCB production and automated PCB

assembly to the manufacture of complex electronic systems. In this

way, Mitsubishi Electric makes a decisive contribution to the competitiveness

of the industry on the global market.

Mitsubishi Electric Europe B.V.

D 40882 Ratingen


page 9/34

The high-power diode laser from the IDEEL research project makes the series production of lithium-ion batteries

significantly more sustainable and economical thanks to the roll-to-roll process. © Fraunhofer ILT, Aachen, Germany

From raw material processing to recycling:

New approaches in battery production

Battery production is at the heart of industrial and climate

policy worldwide. Indeed, the demand for energy storage

systems for electromobility and stationary applications is

growing globally as is the importance of efficient, sustainable

and regionally independent battery production.

In particular, the business and regulatory environment for battery

production presents companies with immense challenges: For

example, the dependence on raw materials such as lithium, cobalt

and nickel is causing geopolitical tensions. At the same time, supply

chains are becoming increasingly fragile as global crises mount and

transportation costs rise. Europe is, therefore, faced with the task of

building a resilient value chain that includes both raw material extraction,

further processing as well as recycling – after all, used batteries

are the most abundant German lithium resource. In addition,

production processes must be flexibly adapted to new battery designs

such as solid-state or sodium-ion batteries in order to secure

investments in them.

In view of these challenges, it is clear that the future of battery

production in Europe can only be secured by using state-of-theart

technologies. Laser technology in particular offers solutions to

meet the key requirements – efficiency, precision and sustainability.

Competitive and sustainable battery production in Europe is hardly

conceivable without innovative laser processes, whether in material

processing, electrode production or recycling.

12 of the 24 partial beams in use: The optics developed by Pulsar

Photonics structures the 300 mm wide band of the battery anode using

the individual partial beams. This significantly improves power density

and charging capacity. © Pulsar Photonics GmbH

Raw material processing and material refinement:

the basis for sustainable battery production

Materials such as lithium and nickel are still components of current

battery cells. Their chemical and physical properties make high

Laser welding of battery cells with a blue laser.

© Fraunhofer ILT, Aachen, Germany


page 10/34

energy densities and long lifetimes possible, but their extraction and

processing pose complex issues.

However, battery technologies are developing rapidly with the

industry aiming at minimizing the use of rare and expensive raw

materials. The Chinese battery manufacturer CATL presented a

sodium-ion battery in 2021 that completely dispenses with lithium

and cobalt. In April 2024, CATL launched a cobalt-free lithium iron

phosphate (LFP) battery that can power an automobile for over

1,000 kilometers on a single charge. In just ten minutes it can charge

enough energy for 600 kilometers, which corresponds to a charging

speed of one kilometer per second.

Toyota plans to use solid-state batteries in hybrid vehicles starting

in 2025. Nissan has put a prototype production plant for laminated

solid-state batteries into operation in Japan. Panasonic has presented

a solid-state battery for drones. VW and Mercedes, Ford and

BMW are about to introduce solid-state batteries or have entered

into strategic partnerships.

A key starting point for new battery technologies is material refinement

at the nano level; here, raw materials are specifically processed

and functionalized to maximize their performance in batteries.

This is what the Surface Technology and Ablation Department

at the Fraunhofer Institute for Laser Technology is examining. With

modern laser technologies it can precisely intervene in the material

structure and to minimize the consumption of resources at the same

time.

Another example of the successful use of laser technologies can

be found in the collaboration between Fraunhofer ILT, the Chair of

Technical structures and any geometrical shape can be applied to the

wafer using inkjet printing, while functionalization is carried out using

laser radiation. The individual loudspeaker elements are then separated

and integrated into an electronic environment.


Laser Technology LLT at RWTH Aachen University, TRUMPF and

the German Electron Synchrotron DESY. By using X-rays from a

particle accelerator, the engineers have been able to gain deeper insights

into laser welding processes. They showed that using lasers

with a green wavelength improves material utilization and reduces

waste. Their findings not only offer technological advantages, but

also contribute to more sustainable production.

„These projects show that innovative laser technology can not

only overcome the challenges of raw material processing, but also

enable sustainable and competitive battery production in Europe,“

explains Dr. Alexander Olowinsky, head of Joining and Cutting at

Fraunhofer ILT.

Electrode production: innovations for sustainable production

The current conductor foils (copper or aluminum) have to be coated

with the electrode materials for the anode and cathode, and subsequently

dried – crucial steps that influence both the energy density

and the cycle life of the batteries. Conventional drying processes based

on convection ovens, however, consume a considerable amount

of energy and require a large amount of space, which limits the sustainability

and efficiency of battery production.

The IDEEL project (Implementation of Laser Drying Processes

for Economical & Ecological Lithium- Ion Battery Production),

funded by the German Federal Ministry of Education and Research,

shows how laser drying solves these challenges: In the project, anodes

and cathodes were dried in a roll-to-roll process for the first

time using a high-power diode laser. This method significantly reduces

energy consumption, doubles the drying speed and halves the

space required.

„Laser drying not only enables more efficient process control,

but also helps to significantly improve the carbon footprint of battery

production,“ explains Dr. Samuel Moritz Fink, group manager

for the Thin-Film Processing group at Fraunhofer ILT. Together with

the project partners, Fink and his team have developed a laser drying

module with adapted optics and process monitoring to ensure

uniform drying. This approach also offers flexibility: Existing convection

ovens can be retrofitted with the laser technology, making

it easier to implement the innovative process in existing production

lines.

In another research project, Fraunhofer ILT is using specially

developed multi-beam optics. This optical assembly splits the laser

beam into several partial beams that simultaneously process a 250

millimeter wide ribbon of a lithium-ion battery anode. This highprecision

structuring increases the energy density and improves

fast-charging capability.

Electrode production also benefits from the integration of artificial

intelligence into the manufacturing process. Researchers at

Fraunhofer ILT are currently investigating how AI-supported systems

can be used to optimize process parameters. Such systems

may not only further increase quality and productivity, but also lay

the foundation for autonomous production.

Cell assembly: precision and efficiency through

innovative technologies

A car control arm with imprinted force sensor measures the forces acting

during use at any time and registers the smallest cracks that occur before

a defect develops. © Fraunhofer ILT, Aachen

In addition to drying the electrodes, the precise joining of the electrode

materials also plays a central role in the performance and reliability

of batteries. Laser microwelding has established itself as a

key technology here since it can join materials such as copper and

aluminum, essential for battery electrodes, without contacting them

and at high precision. Thanks to the low thermal load, the sensitive

cell chemistry remains intact, while the electrical conductivity is op-


page 11/34

timized through reduced contact resistance.

Laser microwelding provides a combination

of flexibility and efficiency that traditional

welding processes cannot match.

The requirements for laser microwelding

vary depending on the cell format, as each

cell type presents specific challenges when

it comes to contacting. Cylindrical cells require

a precise welding depth to ensure electrical

conductivity, on the one hand, and to

prevent damage due to overheating, on the

other. Contacting the negative pole poses

particular challenges, as excessive heat can

damage the sensitive polymer seal, which

could result in electrolyte leakage. In the

case of pouch cells, which are characterized

by their flexible design and high energy density,

welding through the sensitive film coating

must be avoided.

One promising development in cell assembly

can be found the XProLas project,

which TRUMPF is carrying out in collaboration with Fraunhofer ILT

and other partners. They aim to develop compact, laser-driven X-ray

sources that enable on-site quality testing directly at the manufacturer‘s

premises, instead of using large particle accelerators as was

previously the case. This new technology makes it possible to analyze

battery cells in real time, allowing both the charging and discharging

processes and the material quality to be monitored precisely.

This method opens up new possibilities, especially when the cathode

material needs to be examined; the material determines battery

performance and durability. „By using brilliant X-ray sources, we can

detect impurities and material defects at an early stage and, thus,

significantly shorten development times,“ explains Dipl.-Ing. Hans-

Dieter Hoffmann, head of the Lasers and Optical Systems Department

at Fraunhofer ILT.

Here, too, the integration of artificial intelligence opens up additional

potential: AI-supported systems can monitor and adjust

process parameters in real time. With it deviations can be detected

and corrected at an early stage, creating the basis for autonomous

production. The vision of „first-time-right“ production, in which all

components are assembled without errors in the first run, is, therefore,

within reach.

Module and pack production: efficiency and precision

through laser technologies

Using lasers and AI for sustainable battery production: cost-efficient and reliable production.


The individual cells are then connected to form modules or packs.

Precision plays a decisive role at the module level in particular as

several weld seams need to be integrated without increasing the

thermal load on the sensitive cells. Laser processes such as microwelding

enable users to adapt their processes to these requirements

in a tailored manner.

One of Fraunhofer ILT‘s key innovations is the development of

processes that can be used to safely and precisely join aluminum and

copper – two materials with very different physical properties. Using

state-of-the-art laser beam guidance, the institute’s engineers can

control welding depth so as not to damage sensitive cells.

„This technology is essential for the production of modules

and packs that have to function reliably under extreme conditions,

such as high currents and thermal loads,“ explains Olowinsky. One

example of this is the laser welding of large cylindrical cells, which

the Aachen-based institute has continued to develop together with

partners such as EAS Batteries GmbH. Here, they are paying attention

to generating a stable and durable interconnection between the

cells to ensure a long service life and low failure rates.

In addition to laser welding, laser soldering has become established,

particularly for joining heat-sensitive components. This process

works at lower temperatures than traditional welding methods and,

thus, protects sensitive electronics within the modules, making not

only the battery packs more reliable, but also production more energy

efficient.

Battery management and sensor integration:

intelligence for future-proof battery systems

Battery management is one of the central challenges of modern

energy storage systems. The safety, longevity and performance of

batteries depend largely on it – and not least the acceptance of electromobility.

Advances in sensor integration and the use of AI provide

transformative opportunities to meet these requirements.

Traditionally, batteries are monitored at a macroscopic level, but

this only offers limited insights into the complex processes within

the cells. This is where the integration of sensor technology during

production offers new possibilities. Researchers at Fraunhofer ILT

print sensors directly onto components, or even integrate the smart

measuring devices into them. These sensors make real-time monitoring

possible, such as measuring temperatures, forces or even chemical

changes within the batteries when in use.

„With additively manufactured sensors, we can continuously

monitor the condition of the battery modules and react to potential

defects at an early stage,“ explains Samuel Fink. These sensors are

only a few micrometers thick, precise and resistant to mechanical

and thermal stress, all of which make them ideal for use in the battery

and in battery modules. Their ability to provide continuous data enables

predictive maintenance, which detects potential defects before

they occur.

However, the integration of sensor technology alone is not

enough to implement predictive maintenance. Sensors can detect

changes in cell chemistry, while AI algorithms analyze this

data and make predictions about the service life of the cells.

Researchers in the Data Science and Measurement Technology

Department at Fraunhofer ILT are developing such AI-supported

algorithms that analyze large amounts of data from sensors

in real time. These systems also make it possible to dynamically

adapt processes, for example by optimizing temperature profiles


page 12/34

Non-contact exposure and desoldering of circuit board components using laser radiation

in a recycling process of the „ADIR“ project. © Fraunhofer ILT, Aachen, Germany

during cell assembly or adjusting laser welding parameters.

Recycling and reuse: the path to a circular economy in battery technology

Along with the boom in battery technology, the need for sustainable strategies to

recover valuable raw materials is also growing. An effective circular economy is essential

to reduce dependence on primary raw materials while minimizing the environmental

impact of battery production.

In the EU project ADIR, Fraunhofer ILT is working with eight project partners

from three countries to develop a sustainable recycling concept for electronic devices.

The ACROBAT project aims to develop a plan for recycling lithium iron phosphate

batteries before they penetrate the market on a large scale. The aim of the

project is to recover more than 90 percent of the critical materials. Together with

partners such as Accurec Recycling, Fraunhofer ILT is working on innovative separation

and processing methods that are both ecologically and economically sustainable.

The laser experts in Aachen are developing an inline characterization method

to precisely evaluate the quality of the active material.

With its own laser-induced breakdown spectroscopy (LIBS) process, the institute

can precisely identify and separate complex material compositions. The researchers

want to adapt this technology for the recycling of used batteries to further

improve the recovery of metals such as cobalt and tantalum. Here, too, AI can be integrated

to analyze the large amounts of data from laser measurements and optimize

the process in real time. This AI-supported monitoring enables dynamic adjustment

of the recycling parameters, which reduces waste and increases the quality of the

recycled raw materials.

Conclusion and outlook

Battery production is at the heart of the electromobility transition and, thus, the focus

of innovations that combine efficiency, sustainability and technological excellence.

The technologies and developments presented along the production chain

show how state-of-the-art laser processes can pave the way for a sustainable and

competitive battery industry: from raw material preparation and electrode production

to cell assembly and recycling. At the same time, AI-supported analysis and

control systems create a new dimension of process control that improves production

quality and sustainability and further reduces production costs.

In the future, AI-supported control loops could enable autonomous production

in which processes adapt to changing conditions in real time. In addition, laser-driven

X-ray sources and inline characterization technologies open up new possibilities

for quality assurance and material analysis.

Fraunhofer-Institut für Lasertechnik ILT

D 52074 Aachen

NEWSLETTER | EDITION EN 06-2025

page 13/34

Hydrogen economy

Sensors for safe

use of hydrogen

Fraunhofer researchers have developed sensor systems

and measuring equipment that detect leaks in hydrogen

lines and tanks. Applications for the new technology include

continuous monitoring of hydrogen shipments and

facilities in the chemical industry. The researchers use

multiple sensor technologies to provide safety equipment

covering as many scenarios of the future hydrogen economy

as possible.

When it comes to building hydrogen infrastructure, the safety of

pipelines, tanks and connectors is crucial, as the invisible, odorless

gas is highly flammable and explosive. The Fraunhofer Institute for

Physical Measurement Techniques IPM in Freiburg has developed

sensor and measurement systems that reliably detect even the

slightest amount of hydrogen. This makes it quick and easy to detect

leaks of all kinds. The research work was part of the TransHyDE hydrogen

flagship project initiated by the German Federal Ministry of

Education and Research (BMBF) and project management organization

Projektträger Jülich (PtJ). Partners from the research sector

and industry are working together in the project to develop solutions

for transporting and storing gaseous hydrogen. Dr. Carolin Pannek

and the team at Fraunhofer IPM were in charge of the subproject on

safe infrastructure.

Hydrogen is used across a wide range of different scenarios and

applications, so the Fraunhofer researchers developed three different

sensor systems.

Ultrasonic sensor with photoacoustic effect

Light can cause a gas to vibrate, thereby generating sound waves.

The researchers use this photoacoustic effect for their ultrasonic

How the ultrasonic sensor works: The LED light generates

sound waves in the gas. If hydrogen enters the container,

the resonance changes. A MEMS microphone registers the

shift. © Fraunhofer IPM

sensor. In this technology, light is beamed into the device from a light

source, generating resonant sound waves in the gas at a frequency in

the ultrasonic range. When hydrogen enters the container through

a membrane, there is a shift in resonance, which changes the tone.

MEMS (micro-electromechanical systems) microphones register

the change in tone. This method can be used to detect hydrogen

leaking out of tanks or pipelines, for example. “This sensor could be

used to check containers, pipelines or connectors. It would also be

possible to place multiple devices around a room like smoke detectors

and combine them into a sensor network,” explains Pannek, the

project manager at Fraunhofer.

But the ultrasonic sensor can do even more. It is so accurate and

precise that it even registers when molecules of other substances

are present in the hydrogen as minimal levels of contamination. Fuel

cells like those used to generate electricity in trucks require high-pu-

The ultrasonic sensor can be used to monitor hydrogen tanks, pipelines

or connectors. The sensors can also be placed around a room like smoke

detectors to form a network. © Fraunhofer IPM

Hydrogen can be stored and transported in the form of

ammonia (NH3). The laser spectrometer from Fraunhofer IPM

measures and evaluates an absorption line of ammonia. The

system then shows the result on a display. © Fraunhofer IPM


page 14/34

rity hydrogen. The slightest contamination could damage the sensitive

membranes. The sensor can be used in these applications to

check whether the hydrogen is truly pure.

Laser spectrometer

One alternative to laborious storage of hydrogen in high-pressure

tanks in gaseous form or at negative 253 degrees Celsius in cryotanks

in liquid form is the use of ammonia (NH3) as a carrier matrix. This

method considerably simplifies both storage and transportation. But

because ammonia is highly toxic, rapid and reliable leak detection

is vital. Fraunhofer IPM developed a laser spectrometer for remote

detection of ammonia. It absorbs the wavelength of ammonia, so it

reacts immediately. The system then shows the result on a display.

“Specialists can hold our compact device in their hand to check

pipelines or tanks from a safe distance of as much as 50 meters.

Mounted on a robot or drone, it can be used to check industrial facilities

or fly over pipelines,” Pannek says.

Raman spectroscopy

The third measurement system builds on the principle of Raman

spectroscopy. The Raman effect, named for scientist C. V. Raman, is

produced by interactions between light and matter. The light reflected

off the matter has a different wavelength than the light emitted

at the source. This means that every kind of matter has its own spectroscopic

“fingerprint.”

Fraunhofer IPM has years of experience in designing and configuring

Raman systems. For the TransHyDE project, the researchers

developed a filter-based Raman sensor that selectively detects hydrogen

in complex media. The device works with low-cost components

including an inexpensive CMOS camera, plus it is portable, so

it can be used as a mobile testing station for quantifying hydrogen.

The system is used in applications including production of hydrogen

in the energy sector.

Versatile systems, advice on hydrogen projects

All of the sensor systems are designed to be versatile so they can

be adapted for a wide range of different scenarios. The Fraunhofer

experts step in as needed to provide advice to industry customers,

energy suppliers and operators of hydrogen projects on all kinds

of issues surrounding safe use. Pannek is a firm believer in the

future of hydrogen: “The expansion of the hydrogen economy can

start now.”

Fraunhofer-Institut für Physikalische Messtechnik IPM

D 79110 Freiburg

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New MLD Advanced

for RTU syringes

– 100 percent IPC enables flexible

redosing with maximum product yield.

– Gentle processing of up to 400 syringes per minute.

– Combination of proven technologies ensures fast

availability and low risk.

The new MLD Advanced from Syntegon meets the

increasing demands of pharmaceutical manufacturers

for high-output filling solutions for RTU syringes.

Following the first virtual presentation at Interphex, Syntegon is now

introducing its new filling machine for ready-to-use (RTU) nested

syringes to the market. The MLD Advanced meets the increasing

requirements of pharmaceutical manufacturers for high output with

100 percent in-process control (IPC). “Especially with high-value

medicines, it is essential that each drop is filled and weighed optimally,”

explains Markus Burkert, Product Manager at Syntegon.

“That‘s why we have combined the MLD platform, which was previously

used primarily for cartridges and vials, with our technologies

for syringe filling.”

An innovative combination of proven technologies

The automatic bag and tub openers, well-known from many syringe

lines, use no-touch transfer to ensure the aseptic transfer of

the syringes into the filling area. The Pharma Handling Unit developed

by Syntegon denests the syringes automatically without

glass-to-glass contact and places the containers into the pitch adjustment

station. Here, the syringes are moved into the machine

pitch and then placed in the clips of the machine transport. “This

unique clip system is the first key feature we adopted for syringe

applications from the cartridge line,” Markus Burkert explains.

“The special circulating transport system ensures smooth transportation

and is therefore ideal for RTU syringes, as well as vials

and cartridges.”

The empty syringes are weighed using 100 percent IPC, before

they are transferred to the filling station. The subsequent filling

and stoppering process is based on the proven FXS series for syringes:

the filling needles are mounted on the Pharma Handling Unit

and allow for flexible redosing if required. Thanks to IPC, the filling

weight is controlled precisely. “In addition to minimizing product

loss, an important focus is on providing documented proof about the

weighing of each container. This gives manufacturers the certainty

that all containers have been filled correctly,” explains Klaus Ullherr,

Senior Product Manager at Syntegon. After stopper insertion

via vacuum or vent tube, the containers are returned by the circulating

transport system and gently placed in the nests by the Pharma

Handling Unit. “This way, we can offer our customers a seamless

process for their pre-sterilized syringes from a single source,” says

Klaus Ullherr.



D 74654 Crailsheim

Telefon: +49 7951 4020



The first MLD Advanced will soon be ensuring gentle processing

and filling of RTU syringes with 100 percent IPC at a European

pharmaceutical manufacturer.

The filling needles, which are mounted on the Pharma Handling Unit,

enable flexible redosing if required. Thanks to 100 percent in-process

control (IPC), the filling weight is controlled precisely.


page 16/34

Innovation in sensor technology for environmental analysis and medical technology

ISFET-based pH sensor-control

successfully miniaturized and

optimized for easy use

The Fraunhofer Institute for Photonic Microsystems IPMS

has achieved another milestone in chemical liquid analysis.

The electronics required to control the ion-sensitive field

effect transistors (ISFET) have been successfully miniaturized.

At the same time, manufacturing costs and power consumption

have been reduced significantly. The new electronics

can be made available for direct use or for integration

into in-house measuring systems.

ISFETs enable the continuous and precise measurement of pH

values by determining the concentration of certain ions in water or

other aqueous media in real time. Following the outstanding development

of niobium pentoxide-based ISFET pH-sensors, Fraunhofer

IPMS is once again reporting a major success: the new measuring

systems operate with even lower power consumption than

before. “After almost one year of development, we have succeeded in

controlling our Nb2O5-ISFETs to measure continuously with a power

consumption of less than 1.3 mW including electronics,” says Dr.

Olaf R. Hild, Head of the business unit Chemical Sensors at Fraunhofer

IPMS. The power consumption of the sensor system now only

amounts to 190 µW. Power consumption and size are essential parameters

for mobile measuring systems.

Applications arise in continuous water monitoring and environmental

analysis. However, long-term applications in medical technology,

such as the analysis of various body fluids, also require small,

high-performance measuring systems.

The new control electronics, which will be presented at the

“Sensor and Test” trade fair in Nuremberg in May, are particularly

low-power and therefore more energy-efficient, as well as being very

easy to handle and ready for immediate use. They consist of analog

electronics (<1.3 mW) and digital electronics that can be connected

via USB-C (approx. 100 mW), which enables fast on-site calibration:

“As the Fraunhofer IPMS ISFETs are of extremely low-drift and exhibit

almost perfect Nernst dependence, a single-point calibration is

adequate for the vast majority of applications,” explains electronics

developer Hans-Georg Dallmann. This guarantees a high level of accuracy,

even over longer periods of time.

But Hild‘s team is still not satisfied with what they have achieved:

“The next goal is even smaller ISFET chips (< 1mm2) in order

to be able to address size-limited applications. Our cleanroom is

perfectly well equipped for this challenge,” says technologist Falah

Al-Falahi confidently.

Interested parties are warmly invited to get in touch with the

scientists at Sensor + Test. From May 6 to 8, 2025, the latest developments

and possible applications will be presented at Booth 1-317 in

Nuremberg, Germany. Appointments with the experts from Fraunhofer

IPMS can be arranged in advance on the institute‘s website.

Physical principles of the ion-sensitive field-effect

transistor from Fraunhofer IPMS

The novel ISFET from Fraunhofer IPMS is based on a metal-oxide-semiconductor

(MOS) field-effect transistor technology, whereby

the sensor area in contact with the medium consists of an amphoteric

metal oxide layer. Hydronium or hydroxide ions from the

measuring medium are reversibly deposited on this layer according

to the pH value (pH-sensitive layer). The operating voltage (UDS) of

the ISFET, which is applied between the source and the drain, leads

to a current (IDS). This current is always kept constant during the

measurement (constant charge mode). The voltage (UGS) between

the source and the gate or the reference electrode (Ag/AgCl in 3M

KCl) is then used as the measurement signal.

Fraunhofer-Institut für Photonische Mikrosysteme IPMS

D 01109 Dresden

USB-Evaluierungselektronik für ISFETs

des Fraunhofer IPMS. © Fraunhofer IPMS

Low-power analog electronics. © Fraunhofer IPMS


page 17/34

With more than 350 participants from all over the world, the 10th edition

of Pharmatag in Crailsheim set a new visitor record.

“Close collaboration between customers and technology providers

is more important than ever,” said Torsten Türling, CEO of the

Syntegon Group, in his opening speech.

Syntegon Pharmatag 2025:


– 10th edition of Pharmatag with record participation.

– World premiere of SynTiso: innovative line concept for liquid pharmaceutical filling.

– Program presents latest innovations and successful, collaborative partnerships.

On May 20 and 21, 2025, Syntegon, a leading strategic partner to the

global pharmaceutical, biotech, and food industries, hosted the 10th

edition of its industry-leading Pharmatag. A record number of more

than 350 global customers, partners, innovators, and leaders accepted

Syntegon’s invitation to join the event.

“Close collaboration between customers and technology providers

is more important than ever – especially when developing

mission-critical solutions for the pharmaceutical and biotech industries,”

said Torsten Türling, CEO of the Syntegon Group. “The many

successful examples shared at Pharmatag clearly demonstrate this.

What truly sets Syntegon apart is our unwavering commitment to

partnership.”


The program featured a wide range of the latest innovations, expert

insights, and real-world success stories. Among the highlights were

the keynote speeches by Brigitte Reutter-Haerle, VP Product Management

at Vetter Pharma, and Christa Myers, Process Chemical

Engineer at CRB. Both emphasized the importance of collaboration

today to shape the future of the pharmaceutical industry.

Case studies presented by Siegfried Hameln, GennVax, Lek d.d.,

Stevanato Group, and Aspen demonstrated how co-creation is already

delivering tangible results. In addition, a behind-the-scenes

look at Syntegon’s production gave attendees the opportunity to explore

innovative machine concepts and bespoke customer projects

firsthand.

World premiere of innovative new line concept SynTiso

The world premiere of the innovative line concept SynTiso revealed

at Pharmatag exemplifies Syntegon’s new strategy, which focuses on

growth, operational excellence, and long-term value creation. This

strategy aims to build better businesses through seamless processes,

provide customers with access to the most innovative technologies,

and lead the market through sustainable solutions that stand the test

of time.

The SynTiso line concept for liquid pharmaceutical filling was developed

in close collaboration with two partners from the pharmaceutical

industry. SynTiso addresses the current challenges faced by

pharmaceutical manufacturers, who require high availability and full

automation as well as maximum product yield and minimal operator

intervention. “Together with our customers, we will revolutionize

liquid filling,” says Stephan März, Executive VP Pharma Liquid at

Syntegon.



Telefon: +49 7951 4020

D 74654 Crailsheim




page 18/34

Siemens acquires Dotmatics

to extend AI-powered software

portfolio to Life Sciences

– Acquisition of Dotmatics, a leader in Life Sciences R&D software for $5.1 billion

– Expands Siemens‘ market-leading position in industrial software by extending AI-powered Product Lifecycle

Management (PLM) portfolio into Life Sciences to seamlessly connect R&D through manufacturing

– Increases Siemens’ industrial software total addressable market by $11 billion; aligns with strategic goal

to accelerate customer innovation across industries

– Acquisition is another milestone of Siemens’ ONE Tech Company program expanding the Siemens Xcelerator

platform into Life Sciences software with stronger customers focus, faster innovations and higher growth

Siemens AG announces that it has signed an agreement to acquire

Dotmatics, a leading provider of Life Sciences R&D software based

in Boston, for $5.1 billion from Insight Partners. This acquisition

represents a strategic milestone for Siemens, expanding its comprehensive

Digital Twin technology and AI-powered software into this

rapidly growing complementary market. The US company offers a

market leading platform with a highly profitable portfolio of scientific

applications and multi-modal data management for Life Sciences

R&D. The company’s offering accelerates customers’ innovation,

delivering next generation collaboration and contextualized data to

enable AI-powered multi-modal drug development.

“By acquiring Dotmatics, we’re strategically strengthening our

position in Life Sciences and creating a world-leading AI-powered

PLM software portfolio as part of Siemens Xcelerator. Artificial Intelligence

has emerged as a transformative force across various industries,

and its application in Life Sciences is becoming increasingly

important”, said Roland Busch, President and CEO of Siemens

AG. “The Dotmatics acquisition is part of our ONE Tech Company

growth program, enhancing our leading position in industrial software

and helping our customers to innovate even faster.”

“The acquisition of Dotmatics drives strong revenue synergies

and is highly profitable and cash generative. Financing will be provided

primarily through the sale of shares in listed companies, including

Siemens Healthineers,” said Ralf P. Thomas, CFO of Siemens

AG.

“Following an exciting journey with Insight Partners, where Dotmatics

achieved remarkable growth and portfolio expansion, we are

thrilled to announce our new chapter with Siemens,” said Thomas

Swalla, CEO of Dotmatics. “Combining our next-generation scientific

intelligence platform and industry-leading scientific applications

together with Siemens‘ Digital Twin and AI capabilities, we’ll drive

a new wave of innovation in life sciences R&D. Together, we‘ll accelerate

innovation cycles for our customers and help scientists make

breakthrough discoveries faster than ever before shaping the future

of scientific innovation.”

Life Sciences presents an attractive complementary software

market opportunity and expands Siemens’ industrial software total

addressable market by $11 billion. This market is driven by structural

shifts, such as increased medication need driven by aging societies

and improved access to medicine, new treatment options from advancing

science and the necessity for increased collaboration and

visibility across complex value chains. These trends underscore the

need for digital transformation, with software spending expected to

double over the next five years.

Siemens‘ expansion within Life Sciences aligns with its strategic

goal to accelerate customer innovation across the top industries

with the highest R&D spend. The acquisition is part of the investment

track of Siemens’ ONE Tech Company program and following

last week’s closing of Altair’s acquisition, yet another milestone.

This growth program enables Siemens to further expand its market

position and reach the next level of performance and value creation.

Through acquisitions like this, as well as R&D investments into

areas including software, AI-enabled products, connected hardware

and sustainability, Siemens is clearly prioritizing capital allocation

to strategic growth fields. The acquisition of Dotmatics enables Siemens

to scale its technologies into Life Sciences and to fully address

growth opportunities in this market. It will allow Siemens to combine

its comprehensive manufacturing expertise, industrial simulation

and AI capabilities with Dotmatics’ leading complementary applications,

creating a first-of-its-kind end-to-end digital thread that

connects data from research through to production in Life Sciences.

Significant synergies

Dotmatics is expected to generate more than $300 million revenue

in fiscal year 2025 and is highly profitable and cash generative with

an adjusted EBITDA margin of above 40 percent. The company’s

mid-teens revenue growth and high profitability will be immediately

accretive to Siemens’ growth, EBITDA margins and free cash flow,

prior to any synergies. Siemens expects substantial revenue synergies:

Medium-term revenue synergies expected of around $100 million

per year accelerating to over $500 million per year in the longterm.

Capital structure at closing is expected to be within Siemens’

target corridor. Closing of the transaction is anticipated for the first

half of fiscal year 2026 subject to customary closing conditions and

applicable regulatory approvals.

Siemens Aktiengesellschaft

D 80333 München


page 19/34

Kick-off: The Fraunhofer project team and the industry advisory board of „HATE-Fluor“ at the first meeting on Tuesday,

April 8, 2025. © Fraunhofer IFAM

PFAS-substitution, elastomer, technical application

High-performance elastomers

and plasma polymer coatings to

replace fluoropolymers in technical

applications

Users of poly- and perfluorinated alkyl compounds (PFAS),

also known as „forever chemicals“, are under pressure due

to regulatory proposals from the European Chemicals Agency

(ECHA). This also affects the use of fluoroelastomers,

whose economic significance is enormous. Fraunhofer experts

initiated the „HATE-Fluor“ project at the beginning of

February. Together, they want to develop high-performance

elastomer compounds to replace fluoropolymers in certain

technical applications. Various industries can benefit from

this, including manufacturers of semi-finished and finished

parts as well as companies in mechanical engineering

industry, medical engineering, clean room and semiconductor

technology, chemical process technology and electrical

applications.

Many companies are looking for alternatives to poly- and perfluorinated

alkyl compounds (PFAS), as their possible uses in the future

are uncertain and voluntary commitments are expected. PFAS are

found in everyday products such as coated pans, pizza boxes and

outdoor jackets, as well as in medical engineering, heat pumps and

batteries. While there are already fluorine-free substitutes for some

everyday applications, there is a great need for new individual solu-

tions to replace fluoropolymers for technical applications that have

to withstand extreme conditions.

PFAS replacement: coated elastomers and customizable

modular solutions

In the newly initiated „HATE-Fluor“ project, teams of experts at the

Fraunhofer Institute for Structural Durability and System Reliability

LBF and the Fraunhofer Institute for Manufacturing Technology

and Advanced Materials IFAM will develop fluorine-free coated

elastomers and offer customizable modular solutions to meet the

growing market demand. The solution comprises three main steps:

improving the thermal stability of fluorine-free elastomers with novel

antioxidants, producing customized elastomer formulations and

developing a coating system to protect the elastomer from oxidative

and chemical attack.

The modular structure of this system, consisting of paint and

plasma coatings, is intended to cover a broad spectrum in the section

of fluorine alternative seals. The target properties are determined

by the areas of application of the fluoroelastomers that are being

replaced in the project.


page 20/34

In the future, a commercially available fluorine elastomer sealing

ring could consist of a fluorine-free high-performance elastomer with

adapted antioxidants, formulations and a specially developed coating.

© Fraunhofer IFAM

Bundled Fraunhofer expertise

In the „HATE-Fluor“ project, the Fraunhofer Institute for Structural

Durability and System Reliability LBF is concentrating on the

development of high-performance elastomers as a replacement for

fluoropolymers in technical applications. One focus is on improving

the thermal and thermo-oxidative stability of fluorine-free elastomers

using innovative antioxidants. In addition, application-optimi-

zed elastomer formulations are being developed to ensure maximum

resistance and optimum adhesion. This is complemented by the formulation

of a coating system for the elastomers. The latter is being

developed at the Fraunhofer Institute for Manufacturing Technology

and Advanced Materials IFAM to protect the material from oxidative

attack and chemical degradation.

Fraunhofer IFAM is also working within the project on coatings

for these elastomers to improve their friction reduction and barrier

properties. A particular focus is on the development of polyimide

coatings in combination with layered silicates that prevent the permeation

of harmful gases and moisture. These coatings are used in

particular for high-performance electronics and other demanding

applications. In addition, the modification of the layered silicates

is being investigated to reduce the permeation of water vapor and

oxygen through the coating by up to 99%. The application of these

coatings shows significantly reduced ageing and prevents dendrite

growth as a result of exposure to harmful gases.

The Fraunhofer institutes LBF and IFAM are combining their

expertise to develop new solutions and application-ready technologies.

Both institutes already have extensive expertise in PFAS substitution

thanks to many years of development and project work. The

„HATE-Fluor“ project is funded by the Fraunhofer-Gesellschaft as

part of the PREPARE program and will run for three years.

Fraunhofer-Institut für Betriebsfestigkeit und Systemzuverlässigkeit LBF

D 64289 Darmstadt

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Jenoptik manufactures micro-optics for the semiconductor equipment industry

in a state-of-the-art production environment

Jenoptik fab officially

inaugurated in Dresden

After around two and a half years of construction, the Jenoptik

Group has completed its largest single investment in recent history

and officially inaugurated its new factory (or “fab”) in Dresden. By

expanding its production and research and development capacities

for innovative micro-optics, Jenoptik is supporting production technologies

with state-of-the-art, high-precision sensors for high-performance

chips, e.g., for applications in AI.

The new Jenoptik fab in Dresden was officially opened on May

6, 2025 in the presence of customers, partners, construction stakeholders,

neighbors, and representatives from business, politics,

and government agencies of the Free State of Saxony and the City

of Dresden. Together with the Minister President of the Free State

of Saxony, Michael Kretschmer, and the Lord Mayor of the City of

Dresden, Dirk Hilbert, Jenoptik President & CEO Dr. Stefan Traeger

and Site Manager Dr. Andreas Morak pressed the symbolic start button,

which opened the fab with a short light show. Additionally, Jenoptik

has invited around 200 employees from its micro-optics business

in Dresden and Jena to a joint employee celebration to mark the

opening the following day.

“We are proud that we have completed this largest single investment

in the company’s recent history, at just under 100 million euros,

on schedule. In a challenging environment with constantly rising

prices and scarce resources, this is an outstanding achievement. Our

thanks go to everyone involved in the construction, our employees,

and everyone who made this possible,” said Dr. Stefan Traeger, CEO

of JENOPTIK AG.

Saxony’s Minister President Michael Kretschmer emphasized:

“The opening of the new Jenoptik factory in Dresden is a strong signal

for innovation and cooperation in ‘Silicon Saxony’. The fact that

the world-renowned Jenoptik Group has now consolidated its production

of special micro-optics and sensors for the semiconductor

equipment industry here means additional positive effects in terms

of employment and value creation. At the same time, the new factory

will contribute to the further successful development of the semiconductor

ecosystem here, which is unique in Europe. This will not

only strengthen the Saxon economy, but also benefit Germany and

Europe as a whole – through greater European sovereignty and technological

independence in a key industry.”

“The opening of Jenoptik fab will give a further boost to the microelectronics

location. Dresden and Silicon Saxony are leaders precisely

because companies and research institutions here represent

cutting-edge technologies along the entire value chain of the semiconductor

industry. The state capital Dresden is proud to have been

supporting Jenoptik, such an innovative and globally active company

based in East Germany, in its growth for many years now. The fact

that the largest investment project in the company’s history is being

implemented here in Dresden underscores the great confidence in

the location,” said Dresden’s Lord Mayor Dirk Hilbert about Jenoptik’s

investment.

The new fab will make Dresden a major location for Jenoptik’s

micro-optics activities. “We deliberately chose one of the most important

locations for the semiconductor industry in Germany and

Europe, where many global companies and research institutions in

the industry are present,” said Dr. Stefan Traeger at the opening ceremony.

Demanding manufacturing environment

The new high-tech fab now employs almost 100 people in an extremely

demanding manufacturing environment. Production takes


page 22/34

place exclusively in ISO 5 and ISO 3 clean rooms, which

meet the highest requirements for vibration-free operation

and temperature stability. The locations previously

distributed across the City of Dresden are now united

under one roof. The new location offers significantly expanded

production capacities for technologically highly

sophisticated micro-optics and micro-optical sensors.

These are mainly used in systems for semiconductor

lithography and inspection, but also in systems for laser

material processing, for example.

Jenoptik invested just under 100 million euros in the

new site, which has a total net floor space of 11,000 sqm,

including 2,000 sqm for clean room production. In addition,

significant investments were made in state-of-theart

production equipment, some of which was relocated

and some of which was expanded.

High environmental standards

In addition to demanding manufacturing conditions, the

fab also meets high environmental standards: Jenoptik

is in the process of achieving the “KfW 40 Standard”

and “LEED Gold Standard Certification”, which are very

comprehensive and strict building criteria in terms of

sustainability. Recycled materials were used in the construction,

a photovoltaic system has been installed on the

roof, and an energy-efficient building shell as well as a

cooling and heat recovery system were installed alongside

intelligent control technology. In addition, a central

chemical system ensures economical consumption.

Photonics as a growth driver

Jenoptik has been active in Dresden since 2007. In addition

to Dresden, Jenoptik also manufactures its highprecision

and micro-optics at its sites in Jena and Triptis

(polymer optics) in Thuringia, in Heerbrugg, Switzerland,

and in Jupiter (Florida) and Huntsville (Alabama),

USA. The Group employs around 4,600 people worldwide.

Maximum precision in the smallest space

D 07743 Jena

MASTER OF PURITY

Micro-optics and micro-optical sensors are characterized

by maximum precision in the smallest space and a

very flat design. They direct light using micro- and nanostructures

and, unlike conventional optics, are manufactured

using a lithography process similar to that used

in semiconductor production. In addition to chip manufacturing,

they are used in other, primarily technological

manufacturing processes that require highly accurate

and/or very flexible positioning of light for process steps,

such as laser material processing, or quality assurance,

including inspection processes.

The semiconductor equipment industry is the most

important area of application for the micro-optics manufactured

at the Dresden site. Micro-optical sensors

enable, for example, the precise positioning of wafers

during lithographic processes in chip manufacturing.

Areas of application include both DUV (deep ultraviolet)

and EUV (extreme ultraviolet) lithography.

Reinraum-Tücher

HiTech-Sondertücher

Reinraum-Papier

gefertigt im Ostseewerk Lübeck

Labor-Dienstleistungen

CLEAR & CLEAN Werk für Reintechnik GmbH

info@clearclean.de www.cleanboss.de

JENOPTIK AG

NEWSLETTER | Ausgabe EN 06-2025

Seite 23/34

Swiss Biotech Report 2025 highlights sector’s continuing resilience through

commitment to international alliances

Swiss Biotech Report 2025

– Total revenues remain strong at CHF 7.2 billion (CHF 7.3 billion in 2023)

– Record CHF 833 million raised by privately funded companies drives 22% overall rise in capital investment

to CHF 2.5 billion (CHF 2.0 billion in 2023)

– Alentis Therapeutics (CHF 163 million) and SixPeaks Bio (CHF 102 million) lead the way in the private financing rounds

– Despite market headwinds, some public companies report notable successes, e.g. Basilea and Santhera

– Significant M&A and licensing activity reported by companies such as Lonza, Numab, Idorsia, Moonlake,

BioVersys, Haya and AC Immune

– Product approvals by FDA, EMA and Swissmedic increase – including Idorsia’s Aprocitentan

for systemic hypertension and Basilea’s antibiotic Zevtera

– Overall sector R&D investment continues to grow reaching CHF 2.6 billion (CHF 2.4 billion in 2023)

– The increased need for talent by CDMO companies and the success of private biotech R&D companies

have led to further employment growth of around 8%

– Swiss Biotech Day gains recognition as premier global biotechnology conference

with around 3,000 life sciences professionals

During 2024, Switzerland’s biotech sector continued to demonstrate

resilience despite significant financial and market challenges. Revenues

remained strong at CHF 7.2 billion, while R&D investment grew

to CHF 2.6 billion. Especially encouraging was the rise in private

company investment which accounted for a record CHF 833 million

of the total CHF 2.5 billion raised. Public companies also posted several

noteworthy successes. Overall employment grew, particularly

in the expanding Swiss CDMO business. The 2025 edition of the

Swiss Biotech Report, launched today by the Swiss Biotech Association

together with EY and eight other partner organizations, provides

an analysis of 2024 biotech funding as well as other key 2024

metrics and statistics compared to previous years. The theme of the

Swiss Biotech Report 2025 ‘The power of international alliances’

highlights how Switzerland continues to foster such alliances across

all levels of the global life sciences ecosystem – from research and

development to manufacturing and regulatory harmonization – benefiting

the entire industry.

Michael Altorfer, CEO, Swiss Biotech Association, commented:

«In an era when isolationist policies and „me-first“ approaches have

gained traction, Switzerland’s collaborative model offers a compelling

counterproposal. None of the Swiss biotech innovators develops

a new product or technology for the Swiss market alone. Switzerland

has a long tradition of developing innovative products in close collaboration

with strong international partners, thereby providing effective

solutions to global challenges. This approach is so firmly anchored

in the Swiss biotech hub that four out of five biotech patents

filed in Switzerland are the result of international collaboration. At

the same time, Switzerland has assembled a diverse and international

talent pool that strongly facilitates global exchange of experience

and best practices.»

Frederik Schmachtenberg, EY Partner and Global Life Sciences

Lead for Financial Accounting Advisory Services, added: «Despite

difficult headwinds, Swiss biotech companies were able to raise

more than 2.5 billion Swiss francs in funds, an increase of 22 percent

over 2023. Most impressive was the success of private companies in

2024, as record funds of 833 million Swiss francs were raised, and

record 1.4 billion Swiss francs were invested in R&D projects. At the

same time, these companies showed strong revenues of 2 billion

Swiss francs, an increase of 10 percent compared to 2023.»

Key Findings in the 2025 Swiss Biotech Report

Overall revenues generated by the Swiss biotech industry remained

strong, dipping only slightly to CHF 7.2 billion in 2024. Swiss biotech

companies continued to successfully partner with large pharma

companies, including AC Immune with Takeda, Idorsia with Viatris,

Haya with Lilly, and Basilea with Innoviva. Product sales were similarly

boosted by a record number of approvals from Swissmedic,

EMA, FDA and other global regulatory authorities for companies, including

breakthrough advanced therapies from Idorsia, Basilea and

Santhera.

Public markets remained challenging, although CRISPR Therapeutics,

a Swiss biotech that went public in 2016 secured a USD

280 million (CHF 247 million) follow-on financing round to support

ongoing clinical trials in oncology, cardiovascular, and diabetes indications,

and to further expand its autoimmune and gene writing

programs. However, the private funding environment was more encouraging,

with Alentis Therapeutics (CHF 163 million raised) and

SixPeaks Bio (CHF 102 million raised) as the top two private financing

rounds.


page 24/34

In M&A, the standout events were Johnson & Johnson’s purchase

of Yellow Jersey, a demerged subsidiary of Numab, for USD 1.25

billion, and Lonza’s acquisition of Roche’s Vacaville biologics site in

the US for USD 1.2 billion.

The increased need for talent by CDMO companies and the success

of private biotech R&D companies have led to further employment

growth of around 8% – a testament to the depth of the talent

pool. As another significant indicator of the sector’s robustness,

R&D investment continued to grow to CHF 2.6 billion, with a record

CHF 1.4 billion accounted for by private companies.

The 2025 Swiss Biotech Report also underscores the ‘Power of

international alliances’ with two key examples: In 2025, the Swiss

innovation agency Innosuisse assumes the chair of the Eureka innovation

initiative - a network of 47 countries plus the European

Commission - to help strengthen and expand non-dilutive global

research grants. Swissmedic, Switzerland’s regulatory agency, continues

to play a leading role in the Access Consortium, facilitating

joint approvals across Australia, Canada, Switzerland, Singapore,

and the UK.

Global Village and Swiss Biotech Success Stories Awards

for outstanding achievements

The Swiss Biotech Report 2025 was launched at the Swiss Biotech

Day, May 5-6, 2025 in Basel, which attracted around 3,000 delegates.

One contributing factor is the Global Village, a platform hosted by

the Swiss Biotech Association in partnership with other organizations

to encourage worldwide networking and collaboration in biotech

and life sciences. In just two years, the Global Village has already

grown from 10 to 25 international delegations.

To recognize outstanding achievements, the Swiss Biotech

Association presented the Swiss Biotech Success Stories

Awards to:

Dr. Dr. h.c. Henri B. Meier is an entrepreneurial leader who after working

at the World Bank, became finance director at Roche where,

having masterminded the recovery from the patent loss for Valium,

he catapulted them into becoming one of the world’s leading pharmaceutical

companies. Following official retirement in 2000, he has

founded multiple venture funds, foundations, professorships and

start-ups, including the Swiss Future Fund.

Dr. Pascale Vonmont is CEO and Director of the Gebert Rüf Stiftung,

Switzerland’s largest private science and innovation foundation.

For over 25 years, Dr. Pascale Vonmont has been a driving force in

advancing innovation and entrepreneurship. As a passionate bridgebuilder

between science, business, and society, she is committed to

accelerating knowledge transfer and ensuring that groundbreaking

research translates into real-world applications.

The Swiss Biotech Report 2025

The Swiss Biotech Report sheds light on the most important trends,

factors and sources of innovation, and summarizes topics and facts

on the development of the Swiss biotech industry. This year’s theme

is ‘The Power of Global Alliances’.

Swiss Biotech Association

CH 8004 Zürich

Clean solutions for the pharmaceutical

and biotechnology industries

As a system and solution provider of industrial sensor and automation technology, JUMO is a reliable partner – from precise

sensor technology to automation and FDA 21 CFR Part 11-compliant recording. JUMO showcased innovative and efficient

technology at the „LOUNGES“.

„Precise control, effective automation, and comprehensive data

analysis are central challenges in the pharmaceutical industry and

JUMO digiLine CR HT10: It now

allows conductive conductivity

sensors to be connected to the

intelligent, bus-capable JUMO

digiLine system. (Photo: JUMO)

JUMO flowTRANS US W02: Through

the absolutely wear- and maintenance-free

ultrasonic technology, the

flow meter measures with high

precision and independently of

conductivity. It can also be

expanded with temperature and

pressure sensors. (Photo: JUMO)

biotechnology. Additionally, the strictest hygiene standards and international

norms must be adhered to,“ explains Matthias Kremer,

Industry Manager for Water and Wastewater at JUMO. JUMO presents

a diverse portfolio that enables customers to efficiently and

economically manage complex hygienic applications. The portfolio

includes hygienic process connections, EHEDG-certified solutions,

user-friendly automation systems, as well as comprehensive, secure,

and location-independent data analysis and visualization. Furthermore,

JUMO Engineering can tailor systems to the specific needs of

customers.

Capacitive hygrothermometers, multi-sensors for humidity,

temperature, and CO2, as well as differential pressure transmitters,

together with JUMO automation systems, ensure efficient monitoring

and control of cleanrooms. This applies to the pharmaceutical

sector as well as the production of microprocessors or sensors in

cleanrooms.

JUMO GmbH & Co. KG

D 36039 Fulda


page 25/34

FRANK Elektronik invests

in high-precision SMT line

with ASYS machines

FRANK Elektronik, an electronics service provider established in

the market for 25 years, is taking a further innovative step with the

purchase of an ultra-modern SMT line. The company serves wellknown

customers in the industrial electronics, medical technology,

automotive & e-mobility, railway and measurement technology, and

lighting industries.

Under the leadership of Alexei Sub and Robert Both, FRANK

Elektronik has undergone a decisive transformation in the last two

years. While the focus was previously mainly on the assembly of

longboards up to 1500 mm in length, the investment in leading-edge

ASYS technology is creating new possibilities in production.

“With this investment, we have created an additional pillar in

high-value electronics,” explains Robert Both. The new SMT line

enables extremely precise manufacturing processes with high

throughput, while also expanding production capacities for complex

assemblies.

High-tech equipment in detail

The new SMT line combines advanced solutions, such as the very

latest 3D SPI and AOI systems with AI support, the VEGO handling

series and the INSIGNUM 6000 XL laser marker from ASYS, as well

as the SERIO 4000 precision printer from EKRA.

The VEGO handling series ensures a reliable material flow between

production processes thanks to its modular design and robust

construction. It offers the flexibility needed to be prepared for future

requirements in modern production environments.

The SERIO 4000 sets new standards in paste printing. Its MultiClamp

technology ensures maximum stability, while the closedloop

system automatically corrects deviations. The iSET Control

technology also increases process reliability by intelligently capturing

important data such as stencil and paste information.

The INSIGNUM 6000 XL excels in the processing of large-format

printed circuit boards up to 610 x 610 mm. Thanks to the integrated

turning station, it enables double-sided labeling in a single process

step – a decisive advantage for maximum efficiency. In addition,

the built-in scissor lift table ensures stable support of the printed

circuit boards, prevents bending and always guarantees the optimal

focus point for maximum precision.

Service quality as a success factor

The decision in favor of ASYS was influenced not only by the technological

advantages, but also by the quality of service: “The accessibility

and fast support we received from your sales representative

Wolfgang Heyder and the rest of the ASYS team were crucial for us,”

says Robert Both. “We had confidence in ASYS from the very beginning.”

Automation and technological advances

A key advantage of the new line is the closed-loop technology, which

directly links the printing process with the data from the SPI system.

“Print quality is continuously monitored and automatically adjusted

to ensure the highest quality standards,” explains Alexei Sub. Supplemented

by iSET-Control, the production process is further automated

and the need for manual intervention is minimized.

Looking to the future

Thanks to the close cooperation with ASYS, FRANK Elektronik is

optimally prepared for future challenges in industries such as medical

and control technology. “We will consistently continue the path

we have already successfully embarked on of expanding our production

capacities and positioning ourselves in different markets. We

have created the necessary conditions for this, both through our

highly qualified employees and through the investments we have

made,” says Robert Both, summarizing the strategic direction.

Alexei Sub underlines the successful cooperation with ASYS

and emphasizes the trust in the partnership: ‘Should we need another

SMT line, ASYS will again be our preferred partner, provided the

conditions are similar to before’.

f.l.t.r.: Robert Both (Managing Director FRANK Elektronik),

Wolfgang Heyder (Sales Manager ASYS Group),

Alexei Sub (Managing Director FRANK Elektronik).

ASYS Prozess- und Reinraumtechnik GmbH

Lerchenbergstraße 31

D 89160 Dornstadt

Telefon: +49 7348 98560

Telefax: +49 7348 985691

eMail: info@asys-reinraum.de

Internet: http://www.asys-reinraum.de


page 26/34

Flexible and Sustainable Marking of Investigational Drugs

Novel Digital Labels from

Schreiner MediPharm for Clinical Trials

Schreiner MediPharm presents the Digital Display Label, a pioneering solution for digital marking of investigational drugs

in clinical trials. This innovative technology has the potential to replace conventional labels by electronic ones with digital

displays in the future. That makes it possible to eliminate the need for time-consuming manual relabeling, enables significant

process optimization during clinical trials, and helps shorten time-to-market.

Clinical trials entail exacting requirements: Flexibility, speed, and

precision are crucial, and conventional labels with static information

soon reach their limits in that regard. Changes to protocol numbers,

patient groups, or expiration dates as well as regulatory modifications

require manual relabeling of the investigational drugs in many

countries, which causes delays and costs.

Modular System for a Variety of Packaging Forms

The new Digital Display Label from Schreiner MediPharm remedies

this situation: It is based on a modular, reusable plastic housing reliably

protecting the sensitive display electronics. A carefully conceived

adapter system ensures ease of application to a variety of packaging

forms–be it flat blister wallets and kit boxes or round containers

like plastic bottles and vials. For transparent containers, additional

features such as light protection or blinding can be integrated.

Relevant Information in Real Time

A major benefit of the new solution from Schreiner MediPharm is

the possibility to update label information digitally and in real time.

As a result, patients and clinical staff always receive current information

about the investigational drug–without delays and without any

additional investment of materials and logistic effort. That enhances

patient safety and minimizes the risk of discontinuing clinical trials

due to incorrect or obsolete markings.

Sustainability Due to Reusability

In terms of sustainability, the new approach by Schreiner Medi-

Pharm is a compelling solution as well: Both the housing and the

adapter system are reusable, which conserves resources and avoids

waste. The modular design enables integration into existing standard

packaging without requiring modifications. At the same time,

the system ensures a reliable connection between the Digital Display

Label and the primary container or packaging.

In total, the Digital Display Label not only enhances efficiency

in clinical trial logistics but also accelerates the entire trial process

while offering research-based pharmaceutical companies significant

savings potential and higher patient compliance–a crucial move

toward modern, digital clinical trial procedures.

Schreiner MediPharm

D 85764 Oberschleißheim

A reusable plastic adapter system enables reliable attachment

of the Digital Display Label to a variety of packaging forms–from blister

wallets to vials. © Schreiner MediPharm

The Digital Display Label from Schreiner MediPharm has a digital

indicator whose content can be updated in real time—for maximum

flexibility and relevance in clinical trials. © Schreiner MediPharm


page 27/34

An Interview with Elena Mantegazza

Pharmaclean® at the Lounges 2025:

Innovation in Pharmaceutical

Secondary Packaging

The month of March was particularly busy for AM, with a strong presence at international trade shows and events. These

included the Lounges 2025 stood out as a valuable opportunity to present innovative solutions in the pharmaceutical secondary

packaging sector. Elena Mantegazza, Product Specialist at Pharmaclean®, participated as a speaker, bringing a case

study on how Pharmaclean® packaging solutions respond to the new Annex 1 regulations.

How was your experience at

Lounges 2025?

The Lounges 2025 were a very positive experience.

On the one hand, it was a great

opportunity to present pharmaceutical packaging

solutions meeting the needs for regulatory

compliance and innovation. On the

other, it was a time to exchange ideas with

experts and colleagues about the common

challenges we face in the industry. It was

inspiring to see how the market is evolving,

with an increasing focus on reducing contamination

risks and improving sterilization

processes.

Tell us about the case study „Implementation

of bespoke sterility packaging for

autoclave sterilization“

The case study I presented concerned a

customized solution for packaging machine

parts in a Grade C sterile environment,

responding to the requirements of the customer

who was operating a filling plant for

vials and syringes. The main problem was

the use of medical paper as packaging material,

which released particles and broke

easily. The machine parts, which were

heavy and had sharp edges, had irregular

shapes; therefore, a customized packaging

solution was needed that would allow uniform

steam penetration during sterilization.

We then proposed a customized solution

in Tyvek®, a material that offers low

particle release and high strength, ideal for

maintaining product integrity during the

autoclave cycle. Our packaging solved these

problems, ensuring regulatory compliance

without compromising the quality of the

sterilization process.

How do the new Annex 1 regulations fit

into the context of sterilization?

The new Annex 1 has posed major challenges,

requiring specific solutions to minimize

the risk of particulate and microbial contamination.

One of the major changes is the

requirement to use low particle release materials

in aseptic production environments.

Our work has focused on this very issue,

offering customized packaging solutions on

customer request that fully meet these requirements.

With Pharmaclean®, we have

developed a system that not only ensures

the protection of products during sterilization,

but also ensures full traceability and

compliance with international regulations.

How does Pharmaclean® adapt packaging

to the specific needs of customers

in the pharmaceutical industry?

The approach of Pharmaclean® is highly

consultative. Each customer has unique

needs, and it is critical for us to do a thorough

feasibility study. We analyze in detail

the materials to be packaged, weights, shapes,

sizes, and how they assemble on the

carts to ensure that the packaging solution

is a perfect fit. In addition, we offer both

standard and customized solutions for every

need.

Our work is not limited to design: we

produce packaging samples that the customer

can test directly, ensuring that the product

meets the requirements. We then release

the finished product, complete with all

the necessary documentation for validation

and compliance with current regulations.

How is Pharmaclean® innovating in the

pharmaceutical secondary packaging

market?

Innovation is a key part of our philosophy.


page 28/34

We are continuously improving our packaging

solutions to ensure full regulatory compliance

and to offer increasingly effective

solutions. For example, we will soon launch

a new Tyvek®-PET/PP pouch that is another

step toward full compliance with regulatory

requirements. This new material will

provide even greater strength and validated

printing that will avoid chemical residues

during the sterilization process.

What did the experience at Lounges

2025 leave you with?

The Lounges 2025 were a great experience!

Not only was it great to present our innovative

solutions, but it was also a time of professional

growth, where I was able to engage

with colleagues and customers who share

our same passion for quality and innovation.

I look forward to repeating this experience

and continuing to improve our solutions in

the pharmaceutical packaging industry.

AM INSTRUMENTS

Via Isonzo, 1/C

Telefon: +39 02 8728421

IT 20812 Limbiate (MB)

eMail: info@aminstruments.com

Internet: https://global.aminstruments.com/

Consortium to facilitate access to design infrastructure, training, and capital for European fabless

semiconductor startups, small and medium enterprises and research organizations.

Imec coordinates EU Chips Design Platform

A consortium of 12 European partners, coordinated by imec, has

been selected in the framework of the European Chips Act to develop

the EU Chips Design Platform. Funded by Chips JU, the platform

will facilitate access to advanced semiconductor design infrastructure,

training, and capital for fabless semiconductor startups, small

and medium enterprises and research organizations. By providing

the necessary resources, the initiative aims to democratize and foster

semiconductor innovation across Europe, specifically for chip

design.

The semiconductor industry is the backbone of modern technology,

powering everything from smartphones to advanced medical

devices. With the EU Chips Act, Europe is dedicated to increasing

its global semiconductor market share. Next to the launch of European

pilot lines that aim to develop key technologies for semiconductor

innovation, the EU Chips Act has proposed the EU Chips

Design Platform as a vehicle to support the growth of fabless chip

companies in Europe.

The EU Chips Design Platform will enable fabless companies to

access the resources they need quickly and efficiently via a cloudbased

virtual environment, offering chip design resources, training,

Representatives of the twelve consortium members gathered at the

International Iberian Nanotechnology Laboratory in Braga, Portugal.

and capital. Coordinated by imec, twelve key European research

players in the semiconductor ecosystem have joined forces in a consortium

to create this design platform.

The platform aims to onboard the first startups and small and

medium enterprises by early 2026, providing them with low-barrier

access to European design capabilities, including route-to-chip fabrication,

packaging, and testing. It will offer customized support to

access commercial electronic design automation (EDA) tools, intellectual

property (IP) libraries, EU Chips Act pilot line technologies,

and access to design IP repositories, including open-source options.

Additionally, the platform will feature a startup support program with

incubation, acceleration, and mentoring activities next to financial

assistance to help early-stage companies turn their innovative ideas

into reality.

“The EU Chips Design Platform will provide crucial resources

for startups and SMEs to accelerate their design journey and bring

their business ideas to market faster. By reducing the barriers to access

of design expertise, including EDA tools and IP, and drastically

lowering chip design and fabrication costs and time-to-market, we

will spark the growth of the European chip design industry,” stated

Romano Hoofman, imec project coordinator.

The Platform Coordination Team of the EU Chips Design Platform

consists of imec (Belgium), the French Alternative Energies

and Atomic Energy Commission (CEA, France), Fraunhofer-Gesellschaft

zur Förderung der angewandten Forschung e. V. (Germany),

Leibniz Institute for High Performance Microelectronics (IHP, Germany),

Silicon Austria Labs (Austria), Fondaziona Chips-IT (Italy),

Spanish National Research Council (CSIC, Spain), International Iberian

Nanotechnology Laboratory (Portugal), Eindhoven University of

Technology (The Netherlands), Tampere University (Finland), CVUT

(Czech Republic) and AGH University of Krakow (Poland). The grant

agreement with the Chips JU, through the European Union’s Digital

Europe program, is ongoing and will be signed later this year. The

project will run from 2025 until the end of 2028.

IMEC Belgium

BL 3001 Leuven


page 29/34

ASYS Group celebrates its debut at PCIM Europe 2025

A debut with profile: ASYS Group

showcases comprehensive solutions

for power electronics

At its PCIM debut in Nuremberg, ASYS Group is presenting itself as a strong partner for comprehensive manufacturing

solutions in power electronics. “From Prototyping to High-Volume Production” the company will demonstrate how sophisticated

processes, modular technologies, and over 30 years of industry experience work together seamlessly.

The ASYS Group supports customers throughout the entire development

process – from initial prototypes to scalable high-volume production.

The focus is always on partnership-based cooperation with

the customer: processes are not just mapped, but defined, adapted,

and perfected together. This is supported by an experienced team of

experts who combine technological know-how with a deep understanding

of the requirements of power electronics.

New to the trade fair – but with over 30 years of experience

At its PCIM debut, the ASYS Group brings everything the industry

expects: many years of expertise, proven system solutions, and technological

innovations for power electronics manufacturing:

“Our technologies are already an integral part of numerous production

lines in energy and power electronics – so we are in exactly

the right place here in Nuremberg,” says Thorsten Frenzel, Senior

Vice President Sales ASYS Group.

Exhibition highlights: Step by step through

the production process

The ASYS Group‘s exhibition highlights include technologies that

are optimally tailored to the requirements of power electronics – for

a perfect connection between manufacturing solutions and the finished

product:

Highest printing precision for up to 50 substrates:

The SERIO 4000 Optilign is designed for the precise printing of

singulated substrates (individually separated from larger panels and

prepared for further processing) and, thanks to intelligent alignment

and repeat accuracy, ensures the highest print quality for applications

in power electronics. The patented system processes up to 50

substrates of various types, including DBC substrates (direct bonded

copper, ideal for high-performance applications), IMS substrates

(insulated metal substrates with high thermal conductivity, frequently

used in LED and power electronics), and FR4.

Laser cutting with maximum precision:

The POLYPHOS CT series machine platform enables precise laser

cutting of IMS and DBC substrates (e.g., for LED lights or power semiconductors)

using a CNC-controlled system with innovative control,

on-axis camera, and intuitive software interface.

Modular automation with a system:

With the INVENTUS platform, the ASYS Group demonstrates flexible

process integration based on a modular principle – from substrate

handling and laser and screw processes to individual scaling for

different products and growing production requirements.

AI-based inspection for maximum process reliability:

The AOI system AISPECTURE uses 3D laser scanning, high-resolution

imaging, and AI algorithms to precisely inspect components in

the energy sector – reliably and fully inline.


page 30/34

Why it‘s worth a visit

With 30 years of leading expertise in electronics manufacturing,

over 100,000 systems installed worldwide, and a global team of 1,400

dedicated employees, the ASYS Group is a strong partner for futureoriented

solutions in power electronics. The company‘s presence at

PCIM Europe underscores this claim - and makes a visit to booth

4/304 a worthwhile must for trade visitors.

Interested trade visitors can request a free visitor ticket at

event@asys-group.com.

ASYS Prozess- und Reinraumtechnik GmbH

Lerchenbergstraße 31

D 89160 Dornstadt

Telefon: +49 7348 98560

Telefax: +49 7348 985691

eMail: info@asys-reinraum.de

Internet: http://www.asys-reinraum.de

Automated Density Gradient Preparation Reduces Run Times by up to 75%

Beckman Coulter Life Sciences

Transforms Purification with the Launch

of the OptiMATE Gradient Maker

Beckman Coulter Life Sciences, a Danaher company and a global

leader in laboratory automation and innovation, announces the

launch of the OptiMATE Gradient Maker, a groundbreaking instrument

designed to automate the process of density gradient ultracentrifugation

(DGUC). The new system accelerates purification processes

by up to 75% while improving consistency and reproducibility.

Current upstream workflows can take up to 3 days with timeconsuming

steps including stock preparation, mixing and dispensing,

along with tube sealing and up to 48-hours for spinning. The

OptiMATE Gradient Maker slashes that to as little as 6 hours with 4

simple steps from method creation, connecting consumables, method

running, and spinning. The spin process alone shrinks from up

to 48 hours to less than 5 hours by dispensing pre-formed linear gradients

which dramatically reduces centrifuge run times.

“This innovation offers a major breakthrough to expedite purification

workflows,” said Shawn Sternisha, Global Commercial Product

Manager. “By automating the complex and time-consuming

gradient preparation, we’re uniquely able to help laboratories dramatically

reduce tedious, error-prone manual steps while improving the

consistency and reproducibility of their results. This advancement

not only drives efficiency, but also ensures high-quality outputs

which are essential for a wide range of applications.”

The OptiMATE Gradient Maker, for research use only (RUO), is

ideal for the purification of viral vectors such as adeno-associated

virus (AAV). The system simplifies the process of preparing ultracentrifuge-ready

tubes, allowing researchers to achieve high-purity

results with minimal manual intervention. Its plug-and-play design

makes it easy to integrate into existing lab setups without requiring

extensive training, providing a user-friendly solution for busy research

environments.

Intuitive software with a user-friendly design enables operators

to be trained in a matter of hours versus weeks, all in a compact and

space-saving benchtop design.

“The OptiMATE Gradient Maker is designed to meet the growing

demand for faster, more consistent purification,” said Balasubramanian

Venkatakrishnan, Senior Application Scientist. “By unleashing

the benefits of automation to critical steps in gradient preparation,

we’re enabling labs to obtain high-quality results more quickly and

with less variability. This is a key benefit for researchers focused on

high-throughput purification and those looking to improve efficiency

in their workflows, empowering their next big discovery.”

The OptiMATE Gradient Maker will make its debut at the American

Society of Gene & Cell Therapy (ASGCT) in booth 527 May 13-

17, 2025 in New Orleans, LA.

Beckman Coulter GmbH

Europark Fichtenhain B13

D 47807 Krefeld

Phone: +49 2151 333906

email: info@beckmancoulter.de

Internet: https://www.beckman.de/air-particle-counters


page 31/34

E+E Elektronik at Sensor+Test 2025

Step into the World of Trusted Measurement

After a two-year break, E+E Elektronik will once again be exhibiting at Sensor+Test 2025, taking place from 6 to 8 May in

Nuremberg. In Hall 1, Stand 663, the Austrian sensor specialist will be showcasing its latest products under the motto “Step

into the World of Trusted Measurement”. The focus will be on precision and reliability in temperature and humidity control,

as well as on reducing maintenance costs. In Hall 2, in the Calibration Area, E+E Elektronik will also highlight its outstanding

expertise in sensor calibration.

Precision and reliability in temperature

and humidity control are key to improving

product quality and increasing efficiency.

The goal is accurate measurement through

robust sensor solutions, while at the same

time reducing maintenance costs. Thanks to

their modular design, E+E Elektronik’s sensors

are tailored precisely to the individual

systems of their customers. At the trade fair,

innovative technologies will be presented

that make systems and processes not only

smarter, but above all more efficient.

High-Precision Measurements for More

Uniform Drying, Improved Product Quality

and Reduced Waste

In industrial applications, every percentage

point of accuracy matters. Even the smallest

deviation in temperature or humidity can

lead to inconsistent results, longer drying

times or a loss in product quality. High-precision

sensors ensure reliable and uniform

drying, optimise these processes and help

prevent costly waste. Thanks to state-ofthe-art

technology, E+E Elektronik’s humi-

HTS 801 (Photo: E+E Elektronik Ges.m.b.H.)

dity and temperature sensors offer accuracy

of up to 1%.

Presented Solutions:

The HTS801 is a high-precision humidity

and temperature sensor designed for particularly

demanding measurement tasks. It

performs reliably even under challenging

conditions such as high humidity and chemical

contamination. Various probe and

housing options enable operation from -80

°C to 180 °C and up to 300 bar.

The HTP501 digital humidity and temperature

probe is designed for use in drying

chambers and other demanding industrial

applications. The stainless steel probe offers

outstanding measurement accuracy and can

be used in temperatures ranging from -40 to

120 °C. The measured values are available

via the RS485 interface using the Modbus

RTU protocol.

The EE212 humidity and temperature

sensor with interchangeable sensing module

is optimised for demanding HVAC applications

across a wide range of industries.

EE212

(Photo: E+E Elektronik Ges.m.b.H.)

The injection-moulded sensing module

inside the sensor head is extremely robust,

easy to handle and can be replaced without

the need for tools.

Lower Maintenance Costs Thanks to Intelligent

Components

Maintenance costs time and money – especially

when sensors are hard to access or

need to be replaced frequently. E+E Elektronik’s

sensor solutions are modular in design,

allowing sensors and components to

be replaced quickly and easily. This helps to

avoid long and expensive downtimes. Additionally,

the flexible design offers more installation

options and simplifies integration

into existing systems. E+E sensing elements

for humidity, CO₂, pressure and temperature

support maximum efficiency while keeping

maintenance costs to a minimum.

Presented Solutions:

The EE895 module measures not only CO₂

concentration but also temperature and ambient

pressure. The integrated pressure and

temperature compensation minimises the

influence of environmental conditions on

CO₂ measurement. As a result, the EE895

offers particularly high CO₂ measurement

accuracy – regardless of altitude or changing

ambient conditions.

The HTE501 digital humidity and temperature

sensing element offers outstanding

measurement accuracy up to ±1.8 % RH

and ±0.2 °C. The proven E+E sensor coating

and the integrated constant current heater

ensure high reliability and durability, even

in harsh, contaminated or condensing environments.

The TEE501 digital temperature sensing

element impresses with an accuracy of up

to ±0.2 °C and a wide operating temperature

range. The compact DFN housing with

integrated pull-up resistors enables simple

designin of the sensing element.


page 32/34

Versatile, Efficient, Convenient

– Up to 50% Time Savings with the

New Omniport 40

In addition to sensor solutions and sensing

elements designed to increase efficiency,

E+E Elektronik will also present the updated

version of its proven multifunctional handheld

device. The new Omniport 40 focuses

on improving efficiency while reducing

costs – particularly for applications in maintenance

industry.

High-End Sensor Calibration

– Around the World

In Hall 2, in the Calibration Area, E+E

Elektronik will also showcase its outstanding

calibration expertise. As one of the

leading companies in this field, E+E Elektronik

ensures that its devices are calibrated

to the highest quality standards. This

guarantees optimum performance and

compliance.

E+E Elektronik Ges.m.b.H.

Langwiesen 7

A 4209 Engerwitzdorf

Telefon: +43 7235 6050

Telefax: +43 7235 6058

eMail: info@epluse.com

Internet: http://www.epluse.com

The cosmos and the world of screws: both are practically infinite in size and continuously

expanding. Special applications call for special screws – Ganter has them all.

Special Applications Require Special

Screws – Beyond Typical Standards

In machine and plant construction, components are often attached

with screws to allow for easy detachment later. But specific technical

requirements or confined spaces often make typical screws unsuitable.

The screw head may be too tall, for example, or its diameter

too large. Ganter product group 3.2 offers a number of special screw

classes for easily solving such problems.

For example, you will find here under designation GN 912.3 special

screws with normal continuous thread and reduced screw head

diameter. This configuration allows use of these screws in locations

where the distance between the threaded bore or pass-through hole

and the edge of the component is actually too short. The socket cap

screw GN 7984.3 combines a small head diameter with a reduced

head height as well.

If you are looking for even flatter heads, GN 14580.5 will do the

job: the version with M6 thread has a minimal head height of 1.2 mm,

while the M2 is as low as 0.5 mm. This solution is ideal in situations

where countersinking is not an option and it is necessary to compensate

for the tolerances in the hole pattern. Of course, the tightening

torque and load capacity are also reduced accordingly, but the

screw is still ideal for simple fastenings, such as for thin metal plates

or circuit boards.

There are even three types of special screws featuring clever solutions

to prevent loss. These screws have a stud that has been reduced

to the core diameter between the thread and screw head.

This design is used, for example, to attach covers: The screw is

first inserted through a thread in the cover and then engages with

the actual fixing thread on the opposite side. The portion of the stud

without thread is then located in an open bore or cavity. When the

screw is unscrewed from the fixing bore, the thread in the cover prevents

it from falling out. These stainless steel screws therefore satisfy

the current Machinery Directive 2006/42/EC. The dimensions of

screws GN 912.2, which are available in size M3 and larger, are based

on DIN 912. The same functionality is available with GN 7984.2 with

a reduced head height, but if a pan head with Phillips drive is called

for, then GN 7045.2 is the right choice.

With GN 418.3, the head is eccentrically aligned with respect to

the thread axis – if the special screw is turned to the left or right, it

exerts lateral pressure. In this case, the screw thread does not produce

an axial screw force, it only supports the screw laterally. This

makes it ideal for clever fixture designs where lateral tension is desired.

A mark on the top of the screw head indicates the position of

the eccentric element.

Otto Ganter GmbH & Co. KG

Triberger Straße 3

D 78120 Furtwangen

Telefon: +49 7723 65070

Telefax: +49 7723 4659

eMail: info@ganternorm.com

Internet: http://www.ganternorm.com


page 33/34

Redipor by AnalytiChem combining 150+ years of expertise in high quality prepared media,

now manufactured in three production facilities worldwide

AnalytiChem introduces Redipor®

ready-to-use culture

media brand globally

Built on the legacy of three trusted brands – BioTrading,

Redipor by Cherwell, and NEL – Redipor by AnalytiChem brings

together over 150 years of prepared media expertise, innovation

and heritage into one unique global brand.

AnalytiChem, manufacturer of specialized laboratory equipment,

reagents and consumables, has introduced Redipor® ready-to-use

culture media as an AnalytiChem branded product line globally.

Built on the legacy of three trusted brands – BioTrading, Redipor by

Cherwell, and NEL – Redipor by AnalytiChem brings together over

150 years of expertise, innovation and heritage into one unique global

brand. Known for its high quality, reliability and flexibility, Redipor

prepared culture media enables microbiologists across the life

sciences industry to confidently meet their stringent standards and

compliance needs.

AnalytiChem’s Redipor range provides the highest quality, tailored

ready-to-use media products to support critical applications in

Pharmaceutical, Food & Beverage, Environmental, and Healthcare

sectors. The portfolio consists of an extensive collection of media,

batch sizes and packaging options – including plates, bottles, tubes

and vials, plus chromogenic and irradiated media, and universal

operator broth transfer kits. These products can be readily customized

for specific customer needs and regulations.

Manufactured in AnalytiChem’s own state-of-the-art, ISO

9001:2015 certified production facilities in The Netherlands, United

Kingdom and United States, Redipor products can be produced in

proximity to customers, ensuring speed of availability and minimizing

on impact of transportation.

The adaptable processes across AnalytiChem’s three media

manufacturing facilities enable the production of tailored batch sizes,

formulations and packaging solutions. All ensuring Redipor by

AnalytiChem can readily and flexibly meet unique customer requirements,

whatever their critical microbial monitoring application or

location.

“Redipor is a global brand that represents our commitment to

unwavering quality and reliability, in terms of product, supply and

ultimately customer test results,” said Dennis Scheepmaker, Global

Segment Leader, Life Sciences, AnalytiChem. “We understand that

microbiologists across the life sciences industry rely on precision,

consistency and convenience. Through our wealth of expertise in

ready-prepared culture media and local markets we can partner closely

with our customers to ensure smooth workflows for critical applications

and deliver total confidence in test results.”

“As a quality-assured prepared media offering, developed and

produced in parallel by BioTrading, NEL and Cherwell, the products

within the Redipor by AnalytiChem range have been serving

the pharmaceutical manufacturing, clinical, food and environmental

testing markets for over 40 years. So, there is a strong heritage

of quality, performance, flexibility, expertise and understanding of

our customers’ needs,” added Andy Whittard, Managing Director,

Cherwell, an AnalytiChem company. “With the rollout of the Redipor

brand name within the AnalytiChem group, it is going to expand

its reach further afield while maintaining this quality heritage, which

is really exciting.”

“In Redipor by AnalytiChem we are now taking 150+ years of experience

of three different fully accredited media production facilities

and bringing that all together as one truly global high quality,

ready-to-use media brand!” concluded Dennis Scheepmaker.

AnalytiChem Holding GmbH

D 65760 Eschborn

Impressum:

cleanroom online / W.A. Schuster GmbH · Mozartstrasse 45 · D 70180 Stuttgart · Tel. +49 711 9 64 03 50 · Fax +49 711 9 64 03 66

info@reinraum.de · www.cleanroom-online.de · GF Dipl.-Designer Reinhold Schuster · Stgt, HRB 14111 · VAT DE 147811997

Original texts and images

The contributions mentioned by name are the responsibility of the particular author. Reprinting, also of extracts, are permitted only with the approval of

the editor and with reference to the source. The publisher does not accept any responsibility for unsolicited manuscripts and illustrations. The publisher

is granted the exclusive, spatial, temporal and contentual limited right to freely use the article in unchanged or edited form for all purposes as often as

desired or to transfer it to third parties for use. This right of use relates to print and electric media (Internet, databases, data carriers of all kinds).


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