Wellness Foods + Supplements 1/2026

No. 1, April/May 2026 

www.harnisch.com | ISSN 2364-8104 

Longevity 

Skin health 

Maternal and child health 

Plant extracts 

Minerals 

Gut health 

®

5-7 May 2026, Fira Barcelona 

More to 

The world’s nutraceutical 

event is bigger than ever 

Vitafoods Europe returns for its biggest event to date. With an expanded show floor, there 

are more opportunities than ever to discover what’s next in nutraceuticals. 

30,000+ expected attendees 

Connect with thousands of global nutraceutical 

buyers, suppliers and experts 

Discover new products, innovations and insights 

More networking opportunities across 

the entire nutraceutical supply chain 

Book your 

tickets now

Editorial 

SILKE WATKINS, Editor-in-Chief 

Longevity as the new priority 

Longevity is no longer understood as a single 

goal of living longer, but as the art of living 

better for longer. In this issue, that idea 

connects the heart, metabolism, gut health, 

skin health, and the earliest stages of life. 

The modern longevity conversation begins 

with a simple but important insight: ageing 

is not a straight line, but a gradual shift in 

the balance of many connected systems. 

The heart, immune function, microbiome, 

brain and skin all influence one another. 

When one area is under pressure, the others 

often feel the effect as well. That is why 

longevity cannot be reduced to one ingredient, 

one nutrient, or one promise. It must 

be approached as a whole-body strategy. 

Nutrition is a key driver of this shift. Healthy 

ageing depends on everyday habits such as 

diet, movement, sleep and stress management. 

Rather than focusing only on decline, 

it points to a more forward-looking idea of 

health: strengthening the body’s natural 

ability to adapt, recover and stay resilient. 

It is also something that begins much earlier than many people think. 

The first 1,000 days of life are fundamental for future development, 

just as stable nutrition and safety remain crucial in infancy, adulthood 

and later years. In that sense, longevity is a lifelong project. It 

begins with growth, continues through maintenance, and ultimately 

depends on how well we preserve function, independence and vitality 

over time. 

At the same time, beauty and health are increasingly inseparable. 

Skin health, collagen support and cellular protection are no longer 

discussed only in aesthetic terms, but as visible markers of internal 

wellbeing. A healthy appearance often reflects a healthier system 

beneath the surface. This broader perspective is helping to reshape 

consumer expectations and drive innovation across categories. 

The upcoming Vitafoods Europe in Barcelona will once again be an 

important meeting point for the industry and for everyone shaping the 

future of healthy ageing. I hope this issue gives you useful ideas and 

fresh inspiration for supporting health and longevity in everyday life. 

Best regards, 

Silke Watkins 

No. 1 April/May 2026 

3

Contents 

Health 

Convenience Food 

Food & Beverages 

Aging is now viewed as the progressive disruption of 

multiple interconnected systems rather than a single linear 

decline. Redox balance worsens, the immune system shifts 

toward chronic low-grade inflammation, metabolic flexibility 

decreases, intestinal barrier function weakens, and neural 

networks lose adaptability. These processes are captured 

within the “hallmarks of aging,” with inflammaging, the 

chronic sterile inflammation that accumulates with age, 

emerging as a key target for nutritional strategies. In this 

context, Sabinsa has built a longevity-oriented portfolio in 

which branded ingredients are designed to act on several of 

these hallmarks in parallel, from the gut lumen to the brain. 

(See cover story on page 6) 

Confectionary 

Sports Nutrition 

Health Care 

Personal Care 

Contents 

Cover story 

06 Sabinsa’s integrated approach to longevity 

0 Polyphenols 

08 Enhancing polyphenol performance: IsoQ as a new generation of quercetin 

Natural ingredients 

10 Beyond longevity: Indena’s natural solutions for enhanced healthspan and timeless beautyl 

Functional lipids 

14 The longevity mandate: Fostering health from the first cell to the golden years 

Cellular health 

18 Ingood by Olga highlights cellular longevity with SULFODYNE ® l 

Mineral bisglycinate 

20 LomaChelateX ® – Setting the benchmark for modern supplementation 

Supplement concepts 

24 Nutrisun reveals insight-driven concepts at Vitafoods 

Bioactive Collagen Peptides 

26 Maintaining athletic performance in midlife and beyond 

Botanical ingredients 

29 Agilirose ® : A dual-action ingredient for joint health and skin beauty 

Skin health 

36 Pycnogenol ® for smooth skin 

Metabolic health 

40 SelectSIEVE ® HopE: a supercritical CO2– derived Hop phytocomplex 

for metabolic syndrome support 

Weight management 

45 Beyond GLP-1: ingredients for long-term success 

Gut health 

49 Naticol ® Gut: supporting optimal gut balance 

Mother and child health 

52 Probiotics for mothers and children: Nurturing health from day one 

Vitafoods Europe - Preview 

56 Vitafoods Europe unveils programme to help industry navigate 

the sector’s most disruptive trends 

58 Impressum 

4 No. 1 April/May 2026

MartinBauer Nutraceuticals 

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Cover story 

Sabinsa’s 

integrated approach 

to longevity 

Aging is now viewed as the progressive disruption of multiple 

interconnected systems rather than a single linear decline. 

Redox balance worsens, the immune system shifts toward 

chronic low-grade inflammation, metabolic flexibility 

decreases, intestinal barrier function weakens, and neural 

networks lose adaptability. These processes are captured 

within the “hallmarks of aging,” with inflammaging, the 

chronic sterile inflammation that accumulates with age, 

emerging as a key target for nutritional strategies. In this 

context, Sabinsa has built a longevity-oriented portfolio in 

which branded ingredients are designed to act on several of 

these hallmarks in parallel, from the gut lumen to the brain. 

C3 Reduct ® addresses the long-standing challenge 

of curcumin’s low and variable bioavailability 

by providing tetrahydrocurcuminoids 

(THCs), the reduced metabolites generated from 

curcumin in the body, directly. Work in Drosophila 

melanogaster has shown that THC can extend lifespan via the dFOXO 

and Sir2 sirtuin pathway, which is the same axis influenced by caloric 

restriction, with Sir2 deficient flies losing the benefit entirely. THCs 

from turmeric have been evaluated by EFSA as a Novel Food and are 

authorized for use in food supplements for adults at up to 140 mg per 

day, with no safety concerns identified at that intake. 

Nigellin ® is a supercritical 

CO 2 

extract of 

Nigella sativa standardized 

to 5% thymoquinone 

(TQ). Reviews of TQ report that it downregulates 

NF κB and MAPK signaling, moderates 

matrix metalloproteinase activity relevant 

to tissue aging, supports mitochondrial 

antioxidant defenses such as superoxide 

dismutase and catalase, and promotes 

autophagic processes that help maintain 

proteostasis. In a randomized, double blind, 

placebo-controlled trial in subjects with 

allergic rhinitis, a TQ rich Nigella sativa oil 

containing Nigellin ® produced significantly 

greater reductions in symptom scores and 

IgE levels than placebo, indicating clinically 

meaningful immune modulation. 

Silbinol ® and pTeroSol ® 

within Sabinsa’s pterocarpus 

platform provide 

complementary tools for 

metabolic and vascular 


Cover story 

aging. Silbinol ® supplies pterostilbene from 

Pterocarpus marsupium, a naturally occurring 

analog of resveratrol with higher lipophilicity 

and metabolic stability. Pterostilbene 

has been shown to activate SIRT1, influence 

PGC 1α driven mitochondrial biogenesis, 

and support mitochondrial stress responses, 

with studies using Sabinsa’s material in 

diabetic animals reporting superior effects 

compared with resveratrol on blood glucose, 

insulin levels, and skeletal muscle contractile 

function. pTeroSol ® is a water-soluble 

extract of Pterocarpus marsupium standardized 

to C glycosides such as pterocarposide 

and sabioside and has been clinically investigated 

for helping maintain healthy blood 

glucose and lipid parameters in adults with 

early type 2 diabetes. 

Saberry ® , a proprietary 

Emblica officinalis extract 

standardized to 10 % beta 

glucogallin, has been 

shown in vitro to inhibit alpha glucosidase, 

alpha amylase, and DPP 4, three enzymes 

directly involved in postprandial glycemic 

control. In a 90-day multicenter clinical trial 

in newly diagnosed type 2 diabetic subjects 

with dyslipidemia, Saberry ® at 2 g per day 

significantly reduced fasting blood glucose, 

HbA1c, LDL cholesterol, and triglycerides, 

with some endpoints comparing favorably 

with metformin. 

Tinofolin ® is Sabinsa’s 

cognitive health ingredient 

based on Tinospora 

cordifolia. Clinical work with a standardized 

extract has shown improvements in 

verbal learning, logical memory, and recall 

in a placebo-controlled study, consistent 

with its traditional adaptogenic use and its 

proposed modulation of the HPA axis and 

stress response. 

On the microbiome side, 

LactoSpore ® (Bacillus 

coagulans MTCC 5856) is 

a spore forming probiotic 

with strong survival through gastric conditions 

and documented colonization and 

activity in the intestine. Clinical and in vitro 

data indicate that it can modulate inflammatory 

cytokines, support increases in butyrate producing genera, and 

improve both IBS symptoms and depression scores in a gut brain 

axis setting. 

PoZibio ® , a postbiotic derived from heat inactivated 

Lactobacillus paracasei D3.5, has been 

shown in preclinical and early human work to 

enhance mucin production and strengthen the gut barrier, which is 

increasingly recognized as central to controlling systemic inflammation 

and aspects of aging. 

ImmunoSpore ® uses heat inactivated 

Bacillus coagulans MTCC 5856 to 

deliver cell wall components and metabolites 

that can support epithelial integrity and balanced immune 

responses in applications where live spores are not suitable, maintaining 

mechanistic continuity with LactoSpore ® . 

Viewed together, these ingredients reflect a systems biology approach 

to longevity. They target redox status, immune and mitochondrial 

function, glycemic control, cognitive performance, and gut barrier 

integrity in a coordinated way. For formulators and brand owners, 

Sabinsa’s portfolio offers a science anchored toolkit for building next 

generation healthy aging concepts that move beyond single target 

positioning toward integrated support for the biology of aging itself. 

For more information, please contact 

Dr. Umar Jan, PhD, MBA 

President European Operations 

Sabinsa Europe GmbH 

Monzastr. 4a 

63225 Langen, Germany 

umar.jan@sabinsa.eu 

www.sabinsa.eu 


7

Polyphenols 

Enhancing polyphenol 

performance: 

IsoQ as a new generation 

of quercetin 

Dr. Stefan Siebrecht 

Interest in healthy ageing and longevity continues to grow 

across Europe and beyond. While life expectancy has steadily 

increased, the number of years people spend in good health 

has not risen at the same pace. In the European Union, 

average life expectancy is now around 81-82 years, yet 

healthy life remains significantly lower. This gap has intensified 

the focus on strategies that support vitality, energy and 

functional health throughout life. 

In this context, nutrition and supplementation are receiving 

increasing attention. Alongside essential micronutrients, bioactive 

plant compounds such as polyphenols are widely discussed for their 

potential role in supporting metabolic and physiological processes 

related to long-term health. 

One of the best-known polyphenols in this field is quercetin. Naturally 

present in many fruits and vegetables, quercetin has been studied for 

a range of physiological effects. However, despite its promising properties, 

the practical use of conventional quercetin in supplements 

and functional foods has long been limited by a key challenge: it’s 

very low water solubility and poor absorption in the human body. 

Quercetin: promising but limited by bioavailability 

Quercetin belongs to a large group of plant-derived flavonoids and 

is often associated with antioxidant activity and various physiological 

functions. Nevertheless, the compound itself is difficult to formulate 

effectively. 

One reason is its extremely low solubility in water. Conventional 

quercetin in its aglycone form dissolves only minimally, which significantly 

restricts its bioavailability. Even related compounds such as 

rutin or other quercetin derivates show only limited improvements 

in this regard. As a result, relatively high dosages are often required 

in supplements in order to achieve measurable physiologi cal levels. 

These limitations have stimulated research into improved forms of 

quercetin that can deliver better absorption and performance in 

nutritional applications. 

IsoQ: stabilised Quercetin-3-O-Glycoside 

SunActive ® IsoQ represents a new approach to improving the usability 

of quercetin in supplements and functional foods. The ingredient is 


Polyphenols 

based on Quercetin-3-O-Glycoside (Q3OG), a natural compound 

derived from rutin extracted from Styphnolobium japonicum. Q3OG 

can be considered a direct precursor of quercetin that is absorbed 

and converted within the body. 

In its natural form, however, Q3OG is relatively unstable, particularly 

in aqueous environments and under acidic conditions. To overcome 

this limitation, the compound is encapsulated in cyclic maltodextrin 

structures. This technology stabilises the molecule and improves its 

functional properties for use in nutritional products. 

The resulting ingredient, SunActive ® IsoQ, therefore combines a 

bioactive quercetin precursor with a delivery system designed to 

enhance stability and solubility. 

Significantly improved solubility and absorption 

One of the most notable advantages of SunActive ® IsoQ is its dramatically 

increased water solubility. Compared with traditional quercetin 

or rutin, the ingredient is more than 600 times more soluble in water. 

Improved solubility is directly linked to improved bioavailability. 

Studies comparing the absorption of SunActive ® IsoQ with conventional 

quercetin or rutin show a markedly enhanced uptake in the 

body. The absorption can be more than 100 times higher than that 

of conventional forms. 

This improvement also translates into greater efficiency. For example, 

typical supplementation with rutin may require around 600 mg per 

day, corresponding to roughly 360 mg of quercetin. By contrast, 

a daily dosage of about 620 mg of SunActive ® IsoQ contains only 

around 40 mg of quercetin equivalents but can still demonstrate 

significantly higher efficacy. In comparative terms, the ingredient 

can be approximately nine times more efficient than rutin and even 

25-30 times more efficient than conventional quercetin. Such efficiency 

allows product developers to achieve functional effects with 

much lower amounts of active compound. 

Potential functional benefits 

Quercetin and its derivatives have been associated with a number of 

physiological functions. Among the properties discussed are effects 

related to circulation, cardiovascular health and cognitive performance. 

IsoQ is also described as contributing to reduced mental 

fatigue, improved muscle performance and the strengthening of 

veins. 

Furthermore, polyphenols such as quercetin are often examined in 

relation to cellular energy pathways. In longevity research, certain 

compounds are described as activating signalling pathways such as 

AMPK, which are linked to metabolic regulation. In this context, polyphenols 

are sometimes referred to as “molecular training stimuli” 

that trigger beneficial adaptive response within the body. 

While these mechanisms continue to be explored scientifically, they 

illustrate why polyphenols remain a central topic in functional nutrition 

and longevity-related research. 

Opportunities for supplements and functional foods 

For manufacturers of dietary supplements and functional foods, ingredient 

functionality is not only about biological effects but also about 

formulation properties. The improved water solubility of SunActive ® 

IsoQ offers advantages for product development, particularly in applications 

where conventional quercetin is difficult to disperse. 

The ingredient’s stability and enhanced absorption open possibilities 

for a wide range of formats, including capsules, powders and 

beverage formulations. In addition, the higher efficiency compared 

with traditional quercetin sources allows the use of lower dosages 

while maintaining functional performance. 

Conclusion 

As interest in healthy ageing and metabolic health continues to 

expand, the demand for effective bioactive ingredients is growing 

rapidly. Polyphenols such as quercetin remain highly relevant but 

their practical application has long been constrained by poor solubility 

and bioavailability. 

SunActive ® IsoQ addresses these challenges by combining a 

quercetin precursor with a stabilising delivery system that significantly 

improves water solubility and absorption. The resulting ingredient 

offers enhanced efficiency and new formulation opportunities 

for supplements and functional foods. With its improved technological 

and functional properties, IsoQ represents a promising next 

generation of quercetin-based ingredients for modern health and 

wellness applications. 

Interested to learn more about SunActive ® IsoQ? 

Get the NEW SunActive IsoQ at Vitafoods in Barcelona – and secure 

your limited FREE sample directly at our booth! 

Meet our team, and find out what makes SunActive IsoQ so special. 

Meet us in: Vitafoods Barcelona from 05.05.2026 - 07.05.2026, 

Booth 3B122, Hall 3 


TAIYO GmbH 

Hagener Str. 20, 

58285 Gevelsberg, Germany 

www.taiyogmbh.com 


9


Photo © : Adobe Stock/YagaVisuals 

Beyond longevity: Indena’s natural 

solutions for enhanced healthspan 

and timeless beauty 

The global demographic landscape is undergoing a profound 

transformation. The world population is rapidly aging, with 

individuals aged 60 and older projected to double by 2050, 

reaching an astonishing 2.1 billion. This significant demographic 

shift has instigated a re-evaluation of aging, moving 

beyond merely extending lifespan to enhancing “healthspan” 

– the period of life spent in good health, free from chronic 

disease and disability. This paradigm defines the burgeoning 

“age-better” trend, a holistic approach prioritizing physical 

vitality, mental acuity, and social engagement. Individuals 

are no longer content with passive aging; they actively seek 

to maintain independence, pursue passions, and contribute 

meaningfully to society well into their later years. (World 

Health Organization. Ageing and health) 1 

Today’s population is more informed and proactive, viewing aging not 

as an inevitable decline but as a phase to be optimized. This mindset 

drives demand for comprehensive solutions supporting critical functions: 

preserving physical mobility, maintaining cognitive sharpness, 

boosting energy, strengthening immune resilience, and fostering 

emotional well-being. Such a proactive approach fuels significant 

investment in personal health, with many exploring nutrition, exercise, 

and supplementation to achieve their “age-better” goals. 

Healthy appearance: a visible reflection 

of internal vitality 

The pursuit of healthy aging extends beyond 

internal vitality to encompass external 

appearance, reflecting a holistic view of wellbeing. 

A vibrant appearance, particularly 

through healthy skin and hair, has become 

a key indicator of overall vitality and a significant 

component of the “age-better” trend. 

Consumers increasingly recognize that a 

healthy look contributes not only to selfconfidence 

and social engagement but also 

to an improved quality of life. This growing 

awareness fuels a substantial global market; 

the anti-aging segment alone was valued at 

an estimated USD 67.5 billion in 2023 and 

is projected for substantial growth, demonstrating 

a collective commitment to maintaining 

a healthy and youthful aesthetic. 

Individuals seek sophisticated solutions that 

offer lasting results by addressing the underlying 

biological mechanisms of aging. 2 



Indena’s natural ingredients for a 

long, better-aged life 

In this evolving landscape of health expectations, 

Indena stands as a pioneering force, 

dedicating its extensive research to understanding 

cellular aging, optimizing body 

function, and enhancing healthy appearance. 

These three pillars are fundamental 

to achieving healthy longevity. Indena’s 

commitment is reflected in its portfolio of 

specific natural ingredients, each meticulously 

validated through rigorous scientific 

studies, empowering individuals to embark 

on their golden aging journey today. 

CENTEXTRA ® : firm, elastic, restored: 

redefined skin health 

The dermis, the skin’s deeper layer, serves as 

a critical interface, constantly signalling our 

internal health status to the external world. 

Exposed to a barrage of external stressors 

like pollution and UV radiation, as well as 

internal factors such as stress and aging, it 

requires robust support to maintain its integrity 

and youthful vitality. 

Collagen, the body’s most abundant protein, 

is essential for providing structure, strength, 

firmness, and elasticity to skin and other 

tissues. However, the body's natural collagen 

production begins to decrease as early as 

age 25, leading to thinner and more fragile skin, wrinkles, and loss 

of muscle tone. To maintain healthy-looking skin for longer, acting on 

time and accessing natural ingredients that can reactivate endogenous 

collagen production is crucial, preventing long-term deterioration 

without adverse effects. This is precisely what today’s consumers 

and healthcare professionals seek. 

Centella asiatica L., a highly valued botanical, offers numerous 

benefits for skin health. Its remarkable properties are attributed to 

unique triterpenoid acids and derivatives: madecassoside, asiaticoside, 

madecassic acid, and asiatic acid. These active compounds are 

scientifically proven to promote collagen synthesis, support wound 

healing, exhibit anti-inflammatory effects, provide antioxidant protection, 

stimulate microcirculation and help contrast water retention. 

However, as is common with many powerful natural ingredients, the 

full potential of centella is often limited by its inherently reduced bioabsorbability. 

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To unlock the full potential of its premium centella extract while 

preserving its rich phytochemical profile, Indena exploited its multitalented 

proprietary delivery system, Indena Phytosome ® , successfully 

integrating it with the Centella asiatica extract, ensuring its beneficial 

triterpenes remained intact and highly absorbable. The result is 

CENTEXTRA ® , much more than Centella. 

Rigorous preclinical tests conducted by Indena demonstrate 

CENTEXTRA ® ’s superior effectiveness compared to the unformulated 

centella extract. Its advantages are: 

• enhanced antioxidant action: greater protection against reactive 

oxygen species (ROS), mitigating oxidative stress risks; 

• support for healthy inflammatory response: significant reduction 

in intracellular IL-6 release in response to inflammatory stimuli, 

promoting balanced inflammation; 

• promoted/superior cell migration: enhanced wound healing and 

faster skin repair; 

• collagen level restoration: helps restore collagen levels after oxidative 

stress and inhibits collagenase (MMP-1), crucial for maintaining 

skin integrity. 

Moreover, to ensure rigorous control over botanical raw material, 

standardization, and the absence of contaminants, Indena primarly 

sources Centella asiatica from a dedicated agricultural hub in South 

Sardinia. This innovative project utilizes a high-precision, combined 

production cycle integrating phytotrons (climate chambers for precise 

growth control) and 160 completely self-sufficient photovoltaic greenhouses. 

This approach aligns fully with Indena’s ecological sustainability 

mission, guaranteeing unparalleled raw material quality, the 

highest standards, a traceable “Made-in-Italy” sourcing process, and 

a local, transparent supply chain. 

CENTEXTRA ® , the innovative Centella Indena Phytosome ® , stimulates 

collagen production, contributing to thicker, smoother, and more 

radiant skin – truly promoting healthier and restored skin for longer. 

It represents a significant advancement in the holistic management 

of skin aging processes. 

PUREBKALE ® : purification, a foundation of health 

Complementing the strategies for a healthy appearance, Indena offers 

PUREBKALE ® , an innovative food-grade extract designed to support 

the body’s detoxification processes and foster healthy-looking skin. 

Through meticulous screening of Brassica oleracea seed samples, 

known for their beneficial nutrients, Indena identified the optimal 

source for a uniquely high glucoraphanin concentration (≥17 %). 


Indena S.p.A. 

Laura Bo, External communication 

laura.bo@indena.com 

www.indena.com 

Produced exclusively with water as a solvent and leveraging a trusted 

Italian supply chain, PUREBKALE ® underscores Indena's commitment 

to purity and quality. 

Clinical studies have shown that PUREBKALE ® provides significant 

benefits for skin barrier integrity, dermal structure, and various skin 

parameters, establishing it as a viable healthy aging strategy for the 

skin. Improvements were observed in firmness, elasticity, wrinkle 

depth, and dermis density in women experiencing mild-to-moderate 

facial aging signs. 

PUREBKALE ® ’s production demonstrates a strong commitment to 

sustainability, taking place in an ISO 14001 and ISO 45001-certified 

plant. Here, CO 2 

emissions are significantly reduced, energy transition 

initiatives are underway, and occupational health and safety are 

prioritized. Sourced from a 100 % Italian supply chain, the raw material 

benefits from sustainable cultivation practices, ensuring superior 

biomass quality. PUREBKALE ® truly embodies harnessing nature’s 

power for beauty that starts from within. 

Harnessing nature for a timeless quality of life 

The “age-better” trend represents a fundamental and empowering 

shift in how society perceives and approaches aging – an active 

pursuit of longevity, quality of life, and sustained vitality across physical, 

cognitive, emotional, and aesthetic dimensions. As a recognized 

leader in the nutraceutical industry, with its unwavering focus on 

natural and scientifically validated solutions, Indena is uniquely positioned 

as a vital partner in this journey. Through innovative ingredients 

like CENTEXTRA ® and PUREBKALE ® , Indena empowers individuals 

to actively pursue their goals of living longer, healthier, and 

more fulfilling lives, profoundly demonstrating that nature offers 

effective solutions for a timeless quality of life. The foundation of your 

golden aging truly begins today, naturally. 

References 

1 

https://www.who.int/news-room/fact-sheets/detail/ageing-and-health) 

2 

https://www.grandviewresearch.com/industry-analysis/anti-aging-market 


Visit us at 

Vitafoods Europe 

Stand 3B129 

May 5–7, 2026 

Fira Barcelona 

Barcelona, Spain 

CELLULITE 

ELASTICITY 

HYDRATION 

GLOW 

TONE 

The One & Only 

For Your Skin 

www.pycnogenol.com 

*For a complete list of scientific research and further information visit our website at www.pycnogenol.com. Pycnogenol ® , French maritime pine bark extract, is a registered trademark of Horphag Research 

and its applications are protected by U.S. patents and other international patents. ©2026 Horphag Research. 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


The longevity mandate: Fostering health 

from the first cell to the golden years 

Fermentalg believes that understanding the fundamental 

building blocks of life is key to supporting health across the 

lifespan. Their expertise in microalgae fermentation allows 

them to produce key nutrients – the ΩRIGINS functional 

lipids range – that are critical throughout this journey. This 

article explores how targeted nutrition, backed by rigorous 

science and uncompromising safety, supports human health 

across three critical axes: early development, infant safety, 

and proactive support for healthy aging. 

Supporting life, supporting longevity 

The wellness industry is shifting from reactive care to proactive prevention. 

Longevity today is about extending the quality of life, not just 

its duration, and “healthy aging” begins at conception. Consumers 

are no longer satisfied with treating illness—they seek comprehensive 

solutions that optimize daily life and prevent future health issues. 

Omega-3s are recognized as essential nutrients across multiple categories, 

supporting cardiovascular, cognitive, and musculoskeletal 

health throughout life. 

Building lifelong health from the 

start: DHA for pregnancy & lactation 

The journey of longevity begins before birth. 

The “First 1000 Days” (from conception to 

age two) profoundly impact long-term health. 

During this window, the brain, vision and 

nervous system develop rapidly, with DHA at 

the center. DHA is the main fatty acid in the 

brain and the retina, incorporated from the 

third trimester through early infancy. 

The critical role of DHA for mother 

and baby 

Maternal DHA intake is critical: it supports 

the brain and eye development 1 of the fetus, 

relying entirely on the mother’s supply, 

while protecting maternal reserves. DHA’s 

natural transfer from mother to baby can 

lead to peri-natal depletion precisely when 



her resilience is most needed 2 . This depletion 

may destabilize brain neurotransmitters, 

increasing risk of postnatal mood challenges: 

nearly one in five new mothers experiences 

postpartum mood disorders, with 

nutritional deficiencies a contributing factor. 

During breastfeeding, DHA continues to 

transfer to the baby in breast milk along 

with other nutrients, influencing cognitive 

and visual development. This is why the 

World Health Organization (WHO) strongly 

promotes exclusive breastfeeding for the 

first six months of life 3 . 

To maintain pregnant and nursing women’s 

DHA level and support fetus and infant 

development, expert consensus recommends 

600-1000 mg of DHA daily 4 . Yet 

many supplements fail to deliver this dose 

due to formulation and format constraints. 

Women are often advised to take multiple 

large capsules per day, leading to poor 

compliance precisely when consistent 

intake matters most. 

With authorized EFSA health claims backing the role of DHA in fetal 

and infant eye and brain development, DHA ΩRIGINS is the active 

ingredient for brands looking to support mothers and babies during 

this most critical window of life. It is not just an ingredient, it is the 

foundation for lifelong health and longevity. 

From safe beginnings to lifelong health – Protecting the 

most vulnerable in infant nutrition 

Healthy aging does not begin in adulthood - it starts in the earliest 

stages of life. After birth, nutrition continues to shape brain structure, 

visual acuity, and long-term health trajectories. Science is so 

clear that regulators have made it a requirement, not an option: it is 

mandatory to add DHA in infant formulas in Europe to support development 

of babies who cannot be breastfed. This means DHA efficacy 

and absolute safety are paramount to building the foundations 

of lifelong health. 

Recent recalls in the infant formula market have made one thing clear: 

testing limits and frequency are key to ensuring safety. It must be 

built into the system from the start. The crisis exposed vulnerabilities: 

Arachidonic acid (ARA) oil was classified as low risk, thus no EU 

regulatory threshold existed for cereulide (toxin from Bacillus cereus), 

and multi-country supply chains delayed recalls by nearly a month. 

Why choose Algal DHA ΩRIGINS by 

Fermentalg ® ? 

DHA ΩRIGINS, derived from Fermentalg's 

proprietary microalgae strain Schizochytrium 

sp. FCC-3204, is the pioneer in algal DHA 

approval in the EU at 1 g/day. Designed and 

made in Europe, it offers: 

Potency: Naturally concentrated at 

580 mg/g DHA, delivering clinical relevance 

in smaller doses with neutral taste validated 

by an expert panel. 

Safety: Produced in closed fermentation 

tanks preventing exposure to environmental 

contaminants, FSSC 22000 certified, fully 

traceable from algae to finished product. 

Sustainability: 100 % plant-based, 

preserves marine biodiversity, with 25 % 

renewable energy used in 2025. 

The only active & stable 

sulforaphane forme 

Power your cells. 

Unlock Longevity. 

Sulforaphane 

detox activity: 

up to +89% 

via glutathione 

enzymes activation 

CLINICAL 

STUDY 1 

1 : Riedl et al., 2008 

Redefining DHA softgels for mothers-to-be 

ΩRIGINS high concentration enables 

innovation: 500-600 mg DHA in 16-18 

oblong softgels or compact 250 mg softgels: 

ideal for pregnancy when swallowing is difficult. 

DHA ΩRIGINS softgels are vegan, 

carrageenan-free, with optimal freshness 

(low TOTOX) and quality in every dose. 

Join us at 

Vitafoods Europe 

Booth 3.J154D 

May 5-7, 2026 Barcelona 


15


Photo © : Adobe Stock/New Africa 

Fermentalg’s strong analytical framework for infant: 

Dozens of tests per batch 

As Christine Bousses - Fermentalg’s Director of Quality and Analytics 

- explains, tests are conducted on every batch at two critical stages: 

On crude oil: 30+ analyses, including about 20 focused on contaminants 

On ΩRIGINS refined oil: 40+ analyses, including around 20 

focused on contaminants 

Fermentalg guarantees compliance on: 

– 60+ chemical contaminants 

– 500+ pesticides 

– Very low limits on nitrates, nitrites, PAHs, chlorates, perchlorates, 

heavy metals 

– Absence of endocrine disruptors 

– 13 microbiological parameters, including Bacillus cereus, 

Cronobacter, and Listeria monocytogenes 

Proactive screening: Anticipating tomorrow’s risks 

Fermentalg systematically screens for emerging contaminants like 

PFAS, even without regulatory requirements. Their closed fermentation 

system inherently limits exposure pathways, but tests are 

conducted regardless. The absence of a regulatory threshold is not 

the absence of risk. 

Going beyond cocmpliance: A higher standard 

Fermentalg’s DHA ΩRIGINS internal infant specifications are 

often stricter than the most demanding regulations (EU, China, US). 

For several parameters, their guaranteed limits exceed regulatory 

requirements for finished formula, including mercury, 3-MCPD, and 

glycidyl esters. 

Safety as a system: Full traceability 

At Fermentalg, each ΩRIGINS production run starts in Libourne, 

France, with a cryotube of their proprietary strain (FCC-3204). Industrial 

fermentation, extraction and refining all take place in Europe, 

and no step is left uncontrolled throughout the whole process. This 

means full traceability, FSSC 22000 certification, and safety designed 

in, not tested in after the fact. 

In a market shaken by supply chain fragility, 

Fermentalg is bringing a new standard of 

safety, traceability, and quality to functional 

lipids for Infant nutrition. The omega-3 

producer masters this rigorous system for 

its DHA ΩRIGINS oil production. In 2026, 

they are leveraging their expertise to launch 

ARA ΩRIGINS, an arachidonic acid oil 

designed for Infant formula and made in 

Europe following the strictest quality and 

safety standards. Thus, they contribute to 

more than just early development - they help 

build the biological foundations of healthy 

aging. Because longevity is not only about 

adding years to life, but about starting life 

with the strongest possible nutritional base. 

Proactive longevity – EPA & DHA 

fueling body and mind 

As we age, nutrition shifts from development 

to maintenance. Nearly 7 in 10 adults actively 

support cognitive and physical health before 

signs of aging appear 5 . Staying active, sharp, 

and independent is a choice, and nutrition 

is one of the most powerful tools. Among the 

key nutrients supporting this approach, EPA 

and DHA omega-3s like OMEGA ΩRIGINS 

play a central role, supporting health across 

multiple systems. 

Strong body, strong life 

Maintaining physical health is a cornerstone 

of healthy aging, enabling independence, 

mobility, and overall quality of life. EPA 

and DHA contribute to this objective through 

complementary mechanisms acting on the 

cardiovascular system, muscles, and joints. 

Omega-3s are well known to help maintain 

cardiovascular health: they regulate triglyceride 

levels, support normal blood pressure 6 , 

they may improve resting heart rate 7 and 

modulate systemic inflammation 8 . 

Emerging science highlights their role in 

preserving functional fitness — a key to 

autonomy in aging populations. Clinical 

studies suggest benefits in several critical 

areas: 

– Improved mobility 9-10 and endurance 11 , 

– Enhanced muscle 12,13,14 & lower limb 

strength 7 



– Walking speed improvement with 

long-term intake 8 

Joint health is another essential component of physical longevity. EPA 

and DHA help regulate inflammation 15-16 , which may translate into 

reduced joint pain and stiffness 17-18 , as well as potential protection 

against cartilage degradation 19 . 

Sharp mind, clear vision 

Healthy aging isn’t just about the body—it’s about keeping your brain 

sharp and your vision clear. DHA, in particular, plays a structural and 

functional role in the brain throughout life. Observational and clinical 

studies show that higher DHA status is associated with better 

memory and a lower risk of cognitive decline in older adults 20-21 . 

Supplementation with EPA and DHA has also demonstrated benefits 

in populations with mild cognitive impairment, supporting brain function 

as aging progresses. 

Vision health is equally dependent on adequate DHA intake, as it 

accounts for up to 65 % of the retina’s lipid content. Higher levels 

of EPA and DHA have been associated with a reduced risk of agerelated 

macular degeneration 22 , one of the leading causes of vision 

loss after the age of 50 23 . 

The Fermentalg longevity breakthrough: OMEGA ΩRIGINS, the 

first natural 40/20 algal oil 

Fermentalg has developed a patent-pending fermentation process to 

boost EPA in its Schizochytrium FCC-3204 strain, creating OMEGA 

ΩRIGINS EPA/DHA, the most concentrated EPA/DHA algal oil on 

the market (40 % EPA, 20 % DHA) obtained without concentration 

step. This plant-based, much more potent alternative to fish oil is 

designed in France and produced in Europe. To complete this unique 

omega-3 oil, Fermentalg is launching a comprehensive oil range 

answering market needs: 10/50, 15/30, 30/20, and 40/20 EPA/DHA 

ratios. 

With total omega-3 concentration up to 60 %, OMEGA ΩRIGINS 

oils enable smaller softgels, room for other actives, and flexible 

formats (softgels, gummies, powders). Sensory profiles are validated 

by an expert panel. These new EPA/DHA oils offer a true opportunity 

for brands to launch potent, science-backed solutions with EFSAapproved 

claims in the longevity space. 

In conclusion, healthy aging is a journey from conception to the 

golden years. Whether supporting the critical growth of the fetus, 

the resilience of a new mother, the safety of the most vulnerable, or 

the cognitive and physical wellbeing of a senior, targeted nutrition 

is the key to unlocking a longer, healthier life. Fermentalg provides 

the science-backed ingredients and expertise to make this journey 

possible, naturally and sustainably, from the first cell to the golden 

years: the ΩRIGINS functional lipids range. 

References 

1 

EFSA 

2 

ADORE Studies, 2023 

3 

World Health Organization, Breastfeeding 

4 

Cetin et al. 2024 

5 

Actif’s 2025 

6 

EFSA 

7 

Stark, K. D. et al., 2004 

8 

Vors, C. et al., 2021 

9 

Cornish, 2022 

10 

Huang, 2020 

11 

Tomczyk M, & al., 2023 

12 

Santo Andre, 2023 

13 

Smith GI, & al., 2011 

14 

Dalle S, & al., 2021 

15 

Calder, P., 2015 

16 

Serhan CN et al., 2014 

17 

GOED, Omega-3 fatty aids and healthy joints Monograph, 2014 

18 

Kremer JM et al., 1985 and 1987 

19 

Knott L. et al., 2011 

20 

Yurko-Mauro K et al., 2015 

21 

Alex A et al., 2020 

22 

Merle BM et al., 2013 

23 

National Eye Institute, Age-Related Macular Degeneration, 2021 

Photo © : Pexels/Barbara Olsen 


FERMENTALG 

4, rue Riviere 

33500 Libourne, France 

sales@fermentalg.com 

www.fermentalg.com 


17


Photo © : Adobe Stock/rdkcho 

Ingood by Olga highlights cellular longevity 

with SULFODYNE ® 

At Vitafoods Europe 2026, Ingood by Olga will unveil, on 

stand 3J154D, an innovative longevity-focused concept built 

around SULFODYNE ® , the only active, stable and patented 

form of sulforaphane derived from broccoli seeds. 

As longevity continues to emerge as a core pillar of health and nutrition 

innovation, with 57 % of global consumers stating that ageing 

well is now a higher priority than five years ago and the longevity 

and healthy ageing supplements segment growing at close to 8 % 

annually worldwide, the market is shifting from cosmetic anti ageing 

approaches toward science driven solutions that support health span 

and cellular function. 

Powered by SULFODYNE ® , Ingood by Olga addresses this growing 

demand with a science and insights driven healthy ageing approach, 

centred on cellular health, oxidative stress management, and the 

support of the body’s natural defence mechanisms. 

Oxidative stress and inflammation: key drivers of cellular 

ageing 

Cellular ageing is closely linked to two fundamental biological 

processes: oxidative stress and chronic inflammation. With advancing 

age and modern lifestyles, these mechanisms tend to become 

dysregu lated, leading to biological imbalances 

that contribute to cellular damage, 

accelerate the ageing process, and compromise 

overall well being. 

Excessive oxidative stress and persistent 

inflammation are now recognised as underlying 

drivers of cellular dysfunction and 

reduced physiological resilience, making 

their control essential for healthy ageing. 

The Nrf2 pathway: a central longevity 

lever that declines with age 

At the core of cellular protection lies the 

Nrf2 pathway, widely regarded as a pillar 

of healthy ageing. The Nrf2 pathway is the 

master regulator of cellular defence, controlling 

the activation of antioxidant, detoxification, 

anti-inflammatory and cytoprotective 

activities that help cells adapt and respond 

to daily stressors. As we age, its activity 

declines, weakening the body’s antioxidant 

and detoxification capacity. 



Supporting Nrf2 activation therefore represents 

a strategic leverage point to preserve 

cellular health and promote longevity. 

SULFODYNE ® , titrated in 

sulforaphane: the gold standard for 

cellular protection 

Sulforaphane is recognised as a reference 

molecule for Nrf2 activation. Unlike conventional 

broccoli extracts that deliver inactive 

precursors, SULFODYNE ® by Ingood 

by Olga provides sulforaphane directly in 

its free, active and stabilised form, without 

requiring enzymatic conversion in the body. 

Thanks to its patented process, SULFODYNE ® 

offers: 

• Natural, active and stabilised sulforaphane 

• High bioavailability of 70 %, up to 7 fold 

higher than glucoraphanin based broccoli 

extracts¹ 

• Low inter individual variability, ensuring 

consistent biological effects 

Through direct Nrf2 activation, SULFODYNE ® 

supports key healthy ageing mechanisms, 

including antioxidant defence, oxidative 

stress reduction, modulation of inflammatory 

signalling and overall cellular protection. 2,3,4,5,6 

SULFODYNE ® for cellular protection 

and longevity 

SULFODYNE ® supports longevity through 

a multi pillar approach targeting the fundamental 

mechanisms of cellular ageing. By 

acting at the core of cellular defence via Nrf2 

pathway activation, SULFODYNE ® helps 

maintain cellular integrity and long term 

resilience: 

• Antioxidant defence: activation of the Nrf2 

pathway helps protect cells against free 

radicals and reactive oxygen species 

(ROS), reducing oxidative stress. 4,6,7,8 

• Anti inflammatory activity: modulation of 

inflammatory responses supports control 

of chronic low grade inflammation, a key 

contributor to accelerated cellular ageing. 6 

• Cellular energy & mitochondrial support: 

improvement of mitochondrial function 

and integrity, essential for maintaining 

efficient cellular energy production. 11 

• Detoxification support: induction of phase II detoxification enzymes, 

including glutathione enzymes, supporting the elimination of toxins 

and xenobiotics such as atmospheric pollutants, and helping 

4, 6,7,8,9 

reduce cellular toxic burden for long term cellular health. 

• Protection against skin ageing: protection against UV induced skin 

damage through antioxidant and anti inflammatory effects, 

combined with cytoprotective actions and support of skin anti 

ageing mechanisms, notably through activation of the apelin 

signalling pathway. 12 

A comprehensive longevity concept focused 

on cellular health and energy 

The SULFOLONGEVITY concept introduced by Ingood by Olga 

at Vitafoods Europe illustrates a holistic healthy ageing approach, 

powered by SULFODYNE ® as a cornerstone for cellular protection via 

the Nrf2 pathway. Complementary ingredients promoting longevity 

include coenzyme Q10, a NAD + precursor, and Reggenerate, a 

patented vegetarian collagen developed by Circul’Egg, supporting 

cellular energy and skin beauty. 

Presented in a ready to mix stick format, this concept demonstrates 

SULFODYNE ® ’s ability to support premium longevity formulations, 

firmly grounded in science and fully aligned with current market 

expectations 

References 

1 

Fahey et al., 2016; 

2 

Briones-Herrena et al., 2018 

3 

Ruhee & Suzuki, 2020 

4 

Boddupalli et al., 2012 

5 

Ahmed et al., 2016 

6 

Romeo et al., 2024 

7 

Chen M et al., 2021 

8 

Riedl et al., 2008 

9 

Munday et al., 2008 

10 

Egner et al., 2014 

11 

Holmström et al., 2016 

12 

Du et al., 2025 


Ingood by Olga 

2 Rue Julien Neveu, 

35530 Noyal-sur-Vilaine, France 

Tel +33 (0)2 99 04 11 11 

www.ingoodbyolga.com 

Photo © : Adobe Stock/Valerie121283 


19


Photo © : iStock/Eugeniusz Dudzinski 

LomaChelateX ® – Setting the benchmark for 

modern supplementation 

In the race for the next generation of dietary supplements, 

mineral bisglycinates, like magnesium bisglycinate, have 

established themselves as the flagship of a new generation 

of minerals. Once a niche, bisglycinates are now a benchmark 

for modern supplementation – backed by proven performance, 

trusted by consumers worldwide and setting the 

trend for the future of mineral solutions. 

Bisglycinates explained 

Bisglycinates attribute their effectiveness to a simple but powerful 

principle: chelation. Here, a mineral ion is bound to an organic molecule, 

called a ligand, which effectively surrounds and “grabs” a free 

metal ion with multiple coordination bonds. This structure creates a 

stable compound that is the basis for the excellent tolerability and 

high bioavailability of mineral bisglycinates. 

Glycine – The protective shield 

Mineral bisglycinates belong to the broader family of amino acid 

chelates. In bisglycinates, the mineral ion is surrounded by two 

molecules of glycine, the simplest amino acid. Here, glycine acts 

as a protective shield, forming a ring-like structure that prevents the 

mineral ion from unwanted interactions and also allows the mineral to 

pass gently through the stomach and reach the intestine, where the 

ion is released for absorption. The result is 

optimized bioavailability with reduced gastrointestinal 

side effects. 

Magnesium – The all-rounder 

Magnesium is a critical mineral that contributes 

to hundreds of biochemical reactions 

in the human body. It plays a role in many 

physiological functions and is involved in 

energy metabolism, muscle contraction, the 

nervous and immune systems, and bone 

health. By supporting electrolyte balance, 

magnesium also influences fluid regulation 

and performance, an aspect that is 

gaining increasing attention in sports and 

active lifestyles. However, many people do 

not consume enough magnesium through 

their diet alone. Reasons include changing 

eating habits, stress, certain medications, or 

increased needs during specific life stages. 

High-quality supplement forms, such as 

magnesium bisglycinate, provide an effective 



way to reliably support the body’s magnesium 

needs. 

LomaChelateX ® Magnesium Bisglycinate – 

Gentle and effective 

In magnesium bisglycinate, each magnesium 

ion is bound to two molecules of 

glycine. The chelate structure protects the 

metal ion from unwanted reactions with other 

compounds such as interactions with antinutrients 

like phytate. The unique bisglycinate 

structure promotes effective absorption 

of the mineral. A key advantage of magnesium 

bisglycinate is its excellent gastrointestinal 

tolerance. While some magnesium salts 

are associated with laxative effects or digestive 

discomfort, bisglycinate is generally well 

tolerated even at higher intakes. Magnesium 

bisglycinate is also valued for its positive 

effects on the nervous system and sleep 

quality. Along with glycine, it supports relaxation 

and contributes to healthy, restorative 

sleep – benefits that strongly resonate with 

today’s health-conscious consumers. 

LomaChelateX ® – Proof of chelation 

The benefits of magnesium bisglycinate 

only apply to fully reacted material. Only 

in its authentic form it does deliver its welldocumented 

advantages of high bioavailability 

and good tolerance. In contrast, 

simple blends – such as mixtures of magnesium 

oxide with glycine or similar combinations 

– do not provide the same benefits and 

risk mislead or disappoint consumers. Label 

declarations suggesting magnesium bisglycinate content in such 

products are therefore inaccurate and non-compliant. 

All LomaChelateX ® Mineral Bisglycinates are proven chelates. Stateof-the-art 

analytical methods, including nuclear magnetic resonance 

(NMR) and fourier-transform infrared spectroscopy (FTIR), were 

used for their characterization. These techniques clearly differentiate 

bonded from free glycine. The NMR spectrum as shown in figure 1 

for LomaChelateX ® Magnesium Bisglycinate confirms the absence of 

unbound glycine and verifies complete chelation. 

New Type – Fine granular 

LomaChelateX ® Magnesium Bisglycinate is available in a fine-granu lar 

form and stands out for consistent quality, good flow properties, and 

easy handling. It is ideal for capsule formulation and various other 

formats such as instant drink powders, gel pouches and nutrient 

blends. 

To demonstrate the performance of LomaChelateX ® Magnesium 

Bisglycinate in gel pouches a prototype formulation was developed, 

which is outlined in figure 2. 

Ingredients for Magnesium gel pouch % 

LomaChelateX ® Magnesium Bisglycinate 7.14 

Water 58.43 

Glucose 15.0 

Fructose 15.0 

Citric acid 3.8 

Xanthan gum 0.5 

Aroma 0.03 

Potassium sorbate 0.1 

Fig. 2: Gel pouch with LomaChelateX ® Magnesium Bisglycinate 

Iron – The power element 

Iron deficiency is one of the most common nutritional deficiencies 

worldwide. Due to its essential role in numerous physiological functions 

– particularly in hemoglobin, which carries oxygen throughout 

the body – an adequate iron intake is of the utmost importance. 

Supplementation is an effective way to address iron deficiency. 

However, conventional iron salts frequently show gastrointestinal side 

effects and are often less efficient being absorbed. 

Fig. 1: NMR of LomaChelateX ® Magnesium Bisglycinate 

LomaChelateX ® Iron Bisglycinate – Effective and well tolerated 

A key feature of LomaChelateX ® Iron Bisglycinate is that it is both 

well-absorbed and well-tolerated. This makes it especially suitable 

for sensitive groups such as pregnant women, children, and older 

adults, as well as for athletes with higher iron demands. As a fully 

reacted chelate, it ensures efficacy while safeguarding the iron ion 

from absorption-inhibiting compounds such as phytates. 


21


Comprehensive portfolio of fully reacted 

LomaChelateX ® Bisglycinates 

Alongside magnesium and iron, the Loma- 

ChelateX ® portfolio includes zinc, manganese, 

calcium, and copper bisglycinate. 

These minerals are central to immune function, 

bone health, enzyme activity, and 

cellular metabolism. Our broad range of 

LomaChelateX ® Mineral Bisglycinates makes 

it easy to develop formulations with minerals 

in a single, consistent form. 

Photo © : Adobe Stock/Dragana Gordic 

One step ahead in terms of regulation: Dr. Paul Lohmann ® is the first 

manufacturer worldwide to provide full documentation for iron bisglycinate 

as an active pharmaceutical ingredient (API). This makes 

LomaChelateX ® Iron Bisglycinate suitable not only for dietary supplements 

but also for pharmaceutical applications requiring strict regulatory 

compliance. 

LomaChelateX ® Iron Bisglycinate can be used in a range of application 

formats, including powdered beverages. To illustrate this potential, 

figure 3 shows a prototype hydration powder formulation for 

athletes, providing 15 % NRV each of magnesium, iron, and calcium, 

as well as 6 % NRV of potassium. 

Ingredients for electrolyte powder with Iron % 

LomaChelateX ® Ferrous Bisglycinate 0.3 

Mg salt 15.7 

K salt 7.0 

Ca salt 16.3 

Na salt 44.1 

Acidifier 11.5 

Aroma 4.8 

Sweetener 0.3 

All LomaChelateX ® Bisglycinates are fully 

reacted, ensuring authenticity and effectiveness. 

They are applied in several delivery 

formats such as capsules, tablets, powders, 

instant beverages, and functional nutrition 

concepts, giving developers flexibility 

to design targeted solutions ranging from 

immune support to sports nutrition. 

Experience and partnership 

With more than 135 years of expertise in 

mineral production and modern manufacturing 

technology, Dr. Paul Lohmann ® 

delivers consistent product quality while 

remaining flexible to customer needs. Manufacturing 

facilities operate under the highest 

quality standards with clearly defined 

processes. 

From idea to market launch, our R&D team 

supports customers with practical expertise 

and tailored solutions that shorten development 

time, enable clear product differentiation, 

and bring consumer-focused innovations 

to market. Dr. Paul Lohmann ® stands 

for reliability, technical competence, and 

customer focus – values trusted by our partners 

worldwide. 

Fig. 3: Hydration powder with LomaChelateX ® Iron Bisglycinate 


Dr. Paul Lohmann GmbH & Co. KGaA 

Hauptstr. 2, 31860 Emmerthal, Germany 

Tel +49 5155 63-0 

sales@lohmann-minerals.com 

www.lohmann-minerals.com 


Unlock the 

secrets to healthy 

aging – Energize 

mitochondria to 

fuel cellular 

activity. 

Most Tested. Most Trusted. 

Choose MGCPQQ, a safe, all-natural supplement ingredient to 

help support mitochondrial activation and cognitive function. 

MGCPQQ is the only PQQ available in the European Union. 

It is identical to BioPQQ, which is recognized in the U.S., 

Canada and Japan for its quality and safety. 

インフォームド原材料 

Studies suggest taking MGCPQQ regularly can lead to: 

More 

energy 

Improved 

cognitive 

function 

Enhanced 

working 

memory 

Better sleep 

and mood 

Visit Mitsubishi Gas Chemical at booth stand #3D246 during Vitafoods Europe, 5-7 May 2026 in Barcelona, Spain. 

Learn more at www.mgcpqq.eu 

Every effort has been made to ensure that the information contained in this ad is reliable and has been verified. 

The information is intended for a professional audience in a non-commercial context only.

Supplement concepts 

Photo © : Adobe Stock/Pixel-Shot 

Nutrisun reveals insight-driven concepts 

at Vitafoods 

At Vitafoods Europe 2026, Nutrisun showcases three 

insight‐led supplement concepts and enhances its CDMO 

offer with ready‐to‐market solutions and inspiration‐driven 

concepts powered by consumer insights. 

Rooted in consumer understanding and market intelligence, Nutrisun 

will unveil three inspiring concepts all centered on the theme: being 

the best version of yourself. Each concept translates real consumer 

needs into tangible, premium supplement solutions that help brands 

stand out in an increasingly competitive nutrition and health market. 

With more than 30 years of CDMO expertise in nutrition and 

health, Nutrisun has built strong know‐how in powder galenics and 

consumer‐centric formulation. This experience enables the company 

to transform insights into meaningful products, balancing scientific 

credibility, efficiency, and sensory excellence. From premium ingredient 

sourcing to formulation and industrialisation, Nutrisun supports 

partners at every step of the development 

ensuring quality and differentiation. 

At Vitafoods Europe 2026, Nutrisun will 

present three concepts that embody this 

approach. The first, Find Myself, responds 

to the growing mental load experienced by 

modern consumers. With 67 % of women 

reporting a high level of mental load, 

this comforting powdered supplement is 

designed to support focus, mental clarity 

and emotional balance. In a black sesame 

flavour, this latte powder is meant to be 

mixed with almond or cow’s milk. It turns 

a simple break into a moment of realignment, 

helping ease mental load. Powered 

by SelectSIEVE ® Zen by ROELMI HPC, clini- 


cally shown to promote mental relaxation even during periods of high 

mental load, the concept helps calm the mind and sharpen focus 

without causing drowsiness. 

The second concept, Eternal Beauty Sleep, explores the connection 

between rest, recovery and visible wellbeing. With 63 % of 

consumers stating that sleep plays a central role in their beauty 

routines, eternal beauty sleep is a powdered night-time beauty ritual 

designed to support skin beauty during sleep. To be enjoyed hot or 

cold, this hibiscus and lychee flavoured supplement transforms the 

evening moment into a comforting ritual of self-care, just like skincare. 

Powered by upcycled actives and science-backed, Damasty ® 

by Robertet and BeGrape Original by Groupe Berkem, the formula 

helps optimise nighttime recovery to reveal radiant and glowing skin 

by morning. 

Quiet energy responds to another widespread challenge: mental 

fatigue at the end of the day. With 72 % of adults reporting that 

mental fatigue interferes with daily life, especially in the early evening, 

this concept offers a smarter approach to energy. Designed for the 

“second day”, Quiet Energy is a powdered mental energy solution 

to be enjoyed in sparkling water. In a refreshing calamansi flavour, 

it delivers a vibrant experience without overstimulation. Powered by 

Zynamite ® by Nektium clinically studied to reduce mental fatigue 

and provide fast, long‐lasting mental energy without caffeine or sleep 

disruption, it helps consumers stay energised while remaining calm, 

patient, present and fully connected with their loved ones. 

Alongside these three concepts, Nutrisun now introduces two additional 

offers to complement its custom‐made offer: ready‐to‐market 

solutions for faster launches while maintaining strong differentiation, 

and inspiration‐driven concepts powered by consumer insights 

to anticipate future trends and enable fast customisation. All three 

development offers are backed by full‐service support, strong expertise 

in powder formulations and premium ingredient sourcing. 

Nutrisun reinforces its commitment to help brands create products 

that resonate with consumers and perform in real markets. 

Meet Nutrisun at Vitafoods Europe 2026 at booth 3J154E. 


Nutrisun by Olga 

ZI des Rouyardières Secteur B5 

F-35220 Chateaubourg FRANCE 

contact@nutrisun.fr 

www.nutrisun.fr 

No.1 April/May 2026

Bioactive collagen peptides 

Photo © : Adobe Stock/638348101 

Maintaining athletic performance in 

midlife and beyond 

How bioactive collagen peptides support structural resilience 

of the musculoskeletal system in older athletes 

Oliver Wolf 

Sporting great Novak Djokovic perfectly illustrates what is 

possible as – even at nearly 40 – he continues to compete at 

the very highest level in professional tennis. However, in the 

long-term, even exceptional athletes cannot defy the physiological 

processes associated with ageing. While the willingness 

to train may remain strong, the structural capacity of 

the body weakens over time. This is where targeted support 

of the musculoskeletal system becomes a vital component of 

modern sports nutrition, with growing demand for solutions 

that support structural tissues, promote recovery and help 

reduce the risk of injury. Here, Bioactive Collagen Peptides 

(BCP ® ) play a vital role in keeping performance levels high. 

Biological reality 

With increasing age, the musculoskeletal system undergoes both 

structural and functional changes. From around the age of 30, 

endogenous collagen synthesis gradually declines. At the same time, 

the activity of specialised connective tissue cells – such as fibroblasts, 

chondrocytes and osteoblasts – diminishes. The quality and quantity 

of collagen fibres also change, with increased cross-linking leading to 

stiffer, less elastic tissues. 

Collagen is the primary structural protein 

in the human body. It forms the framework 

of tendons, ligaments, cartilage and bone, 

and constitutes a significant part of the 

muscle matrix. Without a functional collagen 

network, mechanical forces can neither be 

effectively transmitted nor absorbed. For 

athletes, this means that every acceleration, 

directional change and landing relies on the 

integrity of collagen-rich structures. 

As collagen production declines, the elasticity 

and load-bearing capacity of tendons 

and ligaments diminishes. Cartilage regeneration 

slows, while degenerative processes 

increase. Bone density also begins to decline, 

particularly from the age of 40. In parallel, 

muscle mass decreases. This, coupled 

with the degeneration of surrounding collagenous 

tissues such as tendons, ligaments 

and fascia, inhibits muscle power and, therefore, 

movement. The result is longer recovery 



times, increased susceptibility to injury, reduced maximal strength 

and ‘explosiveness’. For athletes over 40, the focus therefore shifts 

from pure performance enhancement to resilience and sustainable 

recovery. 

Impact of collagen on performance 

While traditional sports nutrition has long focused on protein, carbohydrates 

and micronutrients, structural integrity is increasingly recognized 

as a key determinant of performance. Collagen is not a typical 

muscle protein, but rather the functional backbone of the musculoskeletal 

system. 

Tendons transmit muscular force to bone, and their performance 

depends on the quality and structure of collagen fibers. Cartilage 

ensures smooth joint movement and consists largely of collagen. 

Bone, in addition to its mineral components, contains an organic 

matrix predominantly composed of collagen, which provides elasticity 

and resistance to fracture. 

When these components lose integrity, performance declines and the 

risk of injury increases. 

This is where specific Bioactive Collagen Peptides (BCP ® ) from 

GELITA come into play, with their mode of action supported by a 

growing body of scientific evidence. 

Bioactive peptides with targeted functionality 

Unlike generic collagen hydrolysates, Bioactive Collagen Peptides are 

characterized by a defined peptide profile. These specific sequences 

act as signaling peptides that, after oral ingestion, enter the bloodstream 

and stimulate targeted connective tissue cells. GELITA’s BCP ® 

portfolio enables manufacturers to develop differentiated products 

with clearly defined physiological benefits and strong scientific positioning. 

TENDOFORTE ® is designed to support fibroblast activity and collagen 

synthesis in tendons and ligaments. Studies indicate that supplementation 

in combination with targeted exercise can promote structural 

adaptations. For athletes over 40, this may translate into improved 

load tolerance and reduced injury risk. Pre-clinical and clinical trials 

have shown its positive effects, especially when combined with physical 

activity. For instance, in a study conducted by the Australian 

Institute of Sport (AIS), subjects with long-term symptoms of chronic 

Achilles tendinopathy who had failed to respond to traditional rehabilitation 

methods were able to return to running within three months 

when supplementing with TENDOFORTE ® , and were able to continue 

running for the remainder of the six-month trial period [1]. 

PeptENDURE ® addresses mitochondrial adaptation processes and 

supports recovery capacity following physical exertion. A recent 

study evaluated TENDOFORTE ® together with PeptENDURE ® during 

concurrent training and showed that 12 weeks’ consumption of 15 g 

of BCP ® per day reduced acute markers of exercise-induced muscle 

damage and accelerated post-exercise recovery [2]. Endurance is 

another area where bioactivity matters. PeptENDURE ® is designed 

to promote adaptive mitochondrial changes associated with longterm 

performance. In two studies that examined men and women 

separately, participants were able to run 14 per cent faster than their 

baselines [3,4]. These positive effects on endurance capacity and 

recovery can help ageing athletes develop more sustainable performance. 

FORTIGEL ® is one of GELITA’s longest established BCP ® brands, 

having been developed some 20 years ago. It is scientifically 

proven to stimulate joint cartilage regeneration and the production 

of collagen and proteoglycans, the two main components of cartilage 

dry mass. It also combats the progressive degeneration of cartilage 

tissue. FORTIGEL ® has been the subject of 20 studies involving 

around 2,800 participants, all of which confirm its stimulating effect 

on the biosynthesis of the extracellular cartilage matrix [5, 6]. The 

studies have demonstrated that the product not only addresses the 

symptoms, but also the cause of joint problems, thus reducing pain 

and improving mobility – key factors for long-term training capacity. 

FORTIBONE ® supports osteoblast activity and contributes to the 

stabilization of the bone matrix, and so helps to maintain density. 

Numerous studies have investigated the impact of supplementation 

of FORTIBONE ® collagen peptides on bone density. For example, 

a study looking at bone mineral density (BMD) in postmenopausal 

women with osteopenia or milder forms of osteoporosis found that 

a daily dose of 5g of FORTIBONE ® for 12 months had an anabolic 

effect, with a pronounced increase in BMD after supplementation 

[7]. There was also an escalation of bone formation, but no changes 

in bone degradation markers. Such data supports the assumption 

that FORTIBONE ® is an innovative ingredient for the formulation of 

products that counteract bone degeneration and support optimal 

bone health. For physically active individuals over 40, who are more 

frequently exposed to microtrauma, this is a critical factor in maintaining 

structural stability. 

With advancing age, resistance training becomes essential to 

counteract sarcopenia. Supplementation with BODYBALANCE ® 

can enhance the effects of regular strength training, contributing 

to increased muscle mass and reduced fat mass. This supports 

improved body composition and overall muscular performance. The 

efficacy of BODYBALANCE ® has been underlined by several studies 

involving different population groups ranging from young, athletic 

men and women to middle-aged, less active and elderly men. In 

one study conducted among young, sporting men, participants 

were divided into two groups – one took BODYBALANCE ® for three 

months, with the other group consuming a placebo. Both groups did 

resistance training three times a week, but at the end of the study 

period, the BODYBALANCE ® group was shown to have had a significant 

increase in muscle (lean body) mass compared to placebo (8). 


27


Photo © : Adobe Stock/546810960 

Technological properties and application potential 

GELITA’s BCP ® are neutral in taste, highly soluble and stable under 

heat and acidic conditions. Their low viscosity and rapid bioavailability 

enable straightforward integration into a wide range of product 

formats, including shots, ready-to-drink beverages, powders, bars 

and gels. For manufacturers, this provides impressive formulation 

flexibility and supports the development of targeted product concepts 

tailored to the needs of consumers aged 40-plus. 

Summary 

Collagen is the structural foundation of the musculoskeletal system. 

As endogenous collagen production declines with age, degenerative 

processes increase, leading to higher injury risk and longer recovery 

times in athletes over 40. At the same time, those remaining physically 

active into later life are driving demand for evidence-based 

sports nutrition that supports structural tissue. 

Specific bioactive collagen peptides such as TENDOFORTE ® , 

PeptENDURE ® , FORTIGEL ® , FORTIBONE ® and BODYBALANCE ® 

provide a scientifically substantiated approach to supporting the integrity 

of tendons, joints, bones and the muscle matrix. For sports nutrition 

manufacturers, this creates new opportunities to develop products 

that not only enhance performance in the short term but also 

help maintain it in the long term, thus supporting active lifestyles 

throughout later life. 


Oliver Wolf, 

Global Product Promotion, 

GELITA AG 

Oliver.Wolf@gelita.com 

www.gelita.com 

References 

[1] Praet et al. (2017) Oral supplementation of specific 

collagen peptides accelerates improvement in Achilles 

tendon symptoms and function in combination with eccentric 

exercise. S Afr J Sports Med 29, suppl 1. 

[2] Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca 

A, König D. Influence of specific collagen peptides and 

12-week concurrent training on recovery-related biomechanical 

characteristics following exercise-induced muscle 

damage - a randomized controlled trial. Front Nutr. 2023 

Nov 16;10:1266056. doi: 10.3389/fnut.2023.1266056. 

PMID: 38035363; PMCID: PMC10687431. 

[3] Jerger S, Jendricke P, Centner C, Bischof K, Kohl J, 

Keller S, Gollhofer A, König D. Effects of Specific Bioactive 

Collagen Peptides in Combination with Concurrent Training 

on Running Performance and Indicators of Endurance 

Capacity in Men: A Randomized Controlled Trial. Sports 

Med Open. 2023 Nov 7;9(1):103. doi: 10.1186/s40798- 

023-00654-9. PMID: 37935999; PMCID: PMC10630299. 

[4] Jendricke P, Kohl J, Centner C, Gollhofer A and König D 

(2020) Influence of Specific Collagen Peptides and Concurrent 

Training on Cardiometabolic Parameters and Performance 

Indices in Women: A Randomized Controlled Trial. 

Front. Nutr. 7:580918. doi: 10.3389/fnut.2020.580918 

[5] Moskowitz RW, 2000: Role of collagen hydrolysate in 

bone and joint disease. Semin Arthritis Rheum, 30, 87 – 

99. 

[6] McAlindon TE, et al. (2021): Change in knee osteoarthritis 

cartilage detected by delayed gadolinium enhanced 

magnetic resonance imaging following treatment with 

collagen hydrolysate: a pilot randomized controlled trial. 

Osteoarthritis and Cartilage. Apr;19(4):399-405. 

[7] Daniel König D, Oesser S, Scharla S, Zdzieblik D, Albert 

Gollhofer A (2018) Specific Collagen Peptides Improve 

Bone Mineral Density and Bone Markers in Postmenopausal 

Women – A Randomized Controlled Study. Nutrients 

2018, 10, 97; doi:10.3390/nu10010097. 

[8] Kirmse et al. (2019): Prolonged Collagen Peptide 

Supplementation and Resistance Exercise Training Affects 

Body Composition in Recreationally Active Men. Nutrients. 

2019 May 23;11(5):1154. doi: 10.3390/nu11051154. 



Photo © : Adobe Stock/F Florian Schultze 

Fig. 1: Plant picture of rosehips (Rosa canina, L.) 

Agilirose ® : A dual-action ingredient 

for joint health and skin beauty 

Ralf Spreemann 1 , Andressa Blainski 1 , Cynthia G. Suarez 1, *, Ivo Pischel 2 

Introduction – When mobility meets 

beauty 

Staying active and looking vibrant are both 

key goals for healthy aging. Traditionally, 

supplements for joint health and skin beauty 

have been seen as separate pursuits. But 

what if one natural ingredient could support 

supple joints and a glowing complexion 

from within? Enter Agilirose ® , a specialized 

rosehip extract that uniquely bridges the 

gap between mobility and beauty. This innovative 

botanical ingredient is gaining attention 

for its dual benefits: promoting comfortable, 

flexible joints while enhancing skin 

hydration, firmness, and overall “beautyfrom-within.” 

Industry experts note that such 

a holistic approach aligns with consumer 

trends – people increasingly recognize that 

true beauty and wellness start from internal 

health. Agilirose ® embodies this convergence, 

offering formulators a science-backed way to address joint 

and skin health together in one formulation. 

The rosehip advantage – Nature’s joint and skin health 

Agilirose ® is derived from the peels of wild Rosa canina (dog-rose) 

berries, an abundant source of bioactives. Rosehips have a long 

history in folk medicine use for relieving aches and nourishing the 

body (Ayati et al. 2018, Shembekar et al. 2025). Modern science is 

now validating these benefits: rosehip extracts are rich in polyphenols 

– potent antioxidants known to quell inflammation and protect 

tissues (Koczka et al. 2018). In Agilirose’s case, key polyphenolic 

compounds promote dermal resilience, joint flexibility, and systemic 

protection, positioning Agilirose ® and its bioactives in “beauty from 

within” and joint health formulations. 

Polyphenols exert multifaceted actions beyond antioxidant defense, 

modulating cellular signaling (Nrf2, NF-κB) and epigenetic mechanisms 

to support collagen synthesis, extracellular matrix integrity, and 

anti-inflammatory balance (Kayahan et al. 2023, Kılıçgün et al. 2010). 

Through these pathways, they promote dermal resilience, joint flexi- 


29


bility, and systemic protection, positioning them as key bioactives in 

“beauty from within” and joint health formulations. 

From wild nature to precision extract 

Harvested from the wild in the pristine regions of southern Chile, the 

rosehips used for Agilirose ® are anything but ordinary. Rather than 

using the whole pseudofruit, Agilirose ® focuses exclusively on the 

nutrient-rich peels – the part of Rosa canina most concentrated in 

polyphenols. 

Modern metabolomic profiling ensures precise botanical identity, 

while a proprietary aqueous extraction and manufacturing process 

preserves and concentrates these valuable actives. The result: a 

clean-label, galactolipid-free extract that stands apart from conventional 

full-fruit rosehip powders or oils. 

Ensuring botanical accuracy: Distinguishing Rosa canina 

from look-alikes 

Due to the high morphological similarity among wild rose species, 

misidentification of Rosa canina is a common and critical issue — 

especially when health claims rely on species-specific evidence. 

Closely related species like Rosa rubiginosa or Rosa dumalis are 

frequently mistaken for R. canina, despite 

lacking the same scientific validation. 

To ensure the botanical identity of Rosa 

canina, we employ an advanced molecular 

diagnostic method based on Purity-IQ ® 

Nuclear Magnetic Resonance (NMR) technology. 

This technique combines nontargeted 

metabolomic profiling with targeted 

analysis of key markers. Spectral data 

are evaluated using multivariate statistics, 

including Principal Component Analysis 

(PCA), Linear Discriminant Analysis (LDA), 

and Hierarchical Cluster Analysis (HCA). 

This orthogonal approach enables a clear 

and reliable distinction of Rosa canina from 

other Rosa species — securing both product 

integrity and consumer confidence. 

The rosehips used for Agilirose ® were 

analysed accordingly and align at a confidence 

interval of ≥95% with authentic 

samples of the Rosa canina species in the 

Purity-IQ Global Registry based metabolomic 

molecular profile. 

A unique extraction for superior 

quality and potency 

One of Agilirose ® ’s distinguishing features is 

its patented manufacturing process, which 

was designed to maximize efficacy of the 

extract. The extraction is 100 % aqueous – no 

organic solvents – ensuring a gentle extraction 

and natural profile, as well as environmentally 

responsible. Extended water extraction 

allows thorough release of actives and 

preserves hydrophilic compounds (like polyphenols, 

flavonoid glycosides, polysa ccharides, 

and organic acids), which are often 

linked to antioxidant, anti-inflammatory, and 

skin or gut health benefits. This extraction 

achieves a high content of polyphenols from 

the rosehip peels, which is far higher than a 

simple herbal tea. 

Fig 2: 1 H NMR spectral profile of the tested Rosehip sample and authentic 

samples of same species in the Purity-IQ ® Global Registry. 

After extraction, the final aqueous extract is 

dried using hydrolyzed collagen as a technological 

carrier. This yields a water-soluble 

powder composed of about 70 % native 

rosehip extract and 30 % collagen peptides. 

The collagen acts as both a drying aid and 



a synergistic ingredient if the recommended doses are provided – 

not just an inert carrier. This means the finished Agilirose ® ingredient 

already includes a beneficial collagen base, aligning with its 

intended use alongside collagen in finished products and clean label 

approaches. 

The result of this process is an ingredient of exceptional standardization: 

Agilirose ® ensures consistent efficacy. Importantly, the 

extract is highly water-soluble and easy to formulate. Agilirose ® 

complies with the high global quality standards for food ingredients, 

is produced under strict GMP conditions, and is Halal certified. 

It was also developed in accordance with ethical principles, 

with no animal testing. Beyond its quality and formulating properties, 

Agilirose ® provides significant benefits at lower recommended dose 

(only 500 mg) than other commercial rosehip powders (usually up to 

10 g). The entire process is patent protected (PCT/EP2008/068081, 

WO2009080778), (Walbroel 2009a) reflecting the updated approach 

to making a rosehip extract optimized for joint and skin applications. 

Dual mechanisms of action – One ingredient, two benefits 

1. Taming inflammation and protecting joints 

Chronic low-grade inflammation is a common thread between joint 

degeneration and skin aging. Agilirose ® addresses this through 

multiple biological pathways. In preclinical models, Agilirose ® showed 

powerful anti-inflammatory effects on joint-related cells. For instance, 

in human cartilage cells (chondrocytes) stimulated to mimic osteoarthritic 

inflammation, Agilirose ® markedly reduced the production of 

key inflammatory mediators: 

Block of Inflammatory Signals: the pro-inflammatory signaling 

proteins like Interleukin-1β (IL-1β), IL-6 and Tumor Necrosis Factoralpha 

(TNF-α), are responsible for pain, stiffness, and the gradual 

damage to cartilage. The most important of these are IL-1β, IL-6, 

and TNF-α, these three are suppressed in the presence of Agilirose ® 

(Feistel 2025, Walbroel 2009b). These cytokines drive pain and cartilage 

breakdown producing joint discomfort prior the onset of osteoarthritis. 

In fact, tests in vitro showed that increasing concentrations of 

the extract led to progressively greater cytokine reduction. At sufficient 

doses, IL-1β and TNF-α levels in inflamed chondrocytes dropped 

significantly compared to the untreated control groups, proving a 

clear, dose-dependent anti-inflammatory action of Agilirose ® . Additionally, 

it lowers prostaglandin E 2 

(PGE 2 

), a mediator of pain and 

inflammation in joints. The net effect is an analgesic (pain-relieving) 

action and preservation of joint structure (Feistel 2025). 

Protects Cartilage Matrix: Agilirose ® also decreases the expression 

of matrix metalloproteinases like MMP-1, MMP-3 and MMP-13, 

enzymes that degrade cartilage collagen and worsen joint damage. 

By curbing MMPs, it helps protect the cartilage matrix from breakdown 

(Feistel 2025). 

Prevents Bone Loss: Agilirose ® ’s benefits may extend to bone health 

underlying the joints. A research team found that the rosehip extract 

blocked the RANKL–NFκB pathway, which is critical for osteoclast 

formation (Appel 2013). RANKL is a factor that triggers immature 

cells to turn into osteoclasts – the cells that break down bone. Agilirose 

® was shown to inhibit RANKL-induced osteoclastogenesis even 

at low concentrations (10 µg/mL). By keeping NF-κB (an inflammatory 

switch) from activating, it prevented the maturation of osteoclasts. 

This suggests Agilirose ® could help reduce bone erosion in conditions 

like osteoarthritis, where bone spur formation and subchondral 

bone loss play a role. It’s a unique mechanism that complements the 

extract’s cartilage-protective actions. 

Fig. 4: Agilirose ® inhibits RANKL-induced osteoclastogenesis. The results 

represent the number of OCL cells per field (10X). At least 6 fields were 

examined in each condition. 

Fig. 3: Agilirose ® shows an inhibitory effect for IL-6 and MMPs. 

Fig. 5: Agilirose ® inhibits RANKL-induced NF-kB activation. 


31


Agilirose ® acts as a shield for joints and bones: it turns down the 

volume on the body’s inflammatory signals and enzymes that cause 

pain and wear-and-tear. Less inflammation means less collagen 

breakdown and cartilage destruction, reducing discomfort and 

allowing for better mobility. This multifactorial mode of action – 

targeting cytokines, enzymes, and even bone metabolism-underlies 

the potent joint-supporting efficacy of Agilirose ® . 

2. Boosting the skin’s radiance and resilience 

The same anti-inflammatory and antioxidant properties of Agilirose ® 

also makes it beneficial for the skin. Just as collagen breakdown 

affects joint cartilage, it also has a major impact on skin health, 

since collagen is one of the main structural proteins that keeps skin 

firm, smooth and elastic. Skin aging is accelerated by inflammation 

(“inflammaging”) and oxidative stress from UV light and pollution. 

Here, Agilirose ® provides a cellular defense and regeneration boost: 

Cutting-edge transcriptomic studies on human keratinocytes 

(HaCaT skin cells) treated with Agilirose ® show a broad genomic 

modulation, with more than 5300 genes significantly regulated 

(Wollenweber 2025, Suarez 2024). This extensive reprogramming of 

gene expression indicates that the extract acts on multiple cellular 

pathways simultaneously, supporting its multifaceted efficacy in skin 

health. Agilirose ® modulates genes particularly those involved in antioxidant 

pathways, anti-inflammatory responses, and epidermal structure 

maintenance. 

Strengthening of the skin barrier and regeneration 

Upregulation of genes involved in lipid metabolism, cellular sig naling, 

and RNA processing indicates improved barrier integrity and 

epidermal renewal. These molecular effects suggest that Rosehip 

extract enhances the skin’s resilience and one stronger barrier function, 

that means better moisture retention and less transepidermal 

water loss, which translates into more hydrated, plump skin. 

Reduction of inflammatory and stress pathways 

Genes associated with inflammation and cellular stress responses — 

such as those in the NF-κB signaling cascade — were downregulated. 

This points to a potent anti-inflammatory action, helping to 

reduce chronic low-grade inflammation (“inflammaging”) and oxidative 

stress within the skin. 

Regulation of cellular differentiation and growth 

The downregulation of genes linked to uncontrolled keratinocyte 

differentiation suggests a normalizing effect on epidermal turnover, 

while the upregulation of genes promoting organized proliferation 

supports a healthy and balanced renewal process — a hallmark of 

youthful skin physiology. 

Integrated anti-aging mechanism 

By simultaneously activating repair and barrier-related genes and 

suppressing pro-inflammatory and degenerative ones, the extract 

demonstrates a coordinated anti-aging genomic signature. This 

provides molecular evidence for its beauty-from-within efficacy — 

helping maintain skin integrity, structure, and youthfulness. 

Collagen Boost 

Agilirose ® also influences genes responsible for the synthesis of 

structural proteins in the skin (Suarez 2025). This includes collagen 

and other extracellular matrix components that maintain skin density 

and elasticity. By modulating these genetic pathways, the extract 

supports the dermal matrix rebuilding process — essentially helping 

skin renew and strengthen itself. 

By simultaneously protecting against oxidative stress and promoting 

the production of structural skin proteins, Agilirose ® offers a two-fold 

beauty benefit: it helps guard the skin from environmental aging while 

actively supporting skin renewal from within. This is the essence of 

“beauty-from-within” — nourishing the skin at the cellular level so 

that outwardly it appears more hydrated, firm, and radiant. 

Synergy with collagen peptides – Better together 

Agilirose ® was formulated to exploit a synergistic interaction between 

Rosa canina peel extract and collagen peptides. The combination was 

conceived to enhance both structural regeneration and biochemi cal 

modulation rather than serve as a simple carrier system. Collagen 

peptides supply key amino acids that promote synthesis of extracellular 

matrix components in cartilage, bone, and skin, while Agilirose ® 

provides complementary anti-inflammatory and regulatory cues that 

facilitate effective tissue remodeling. 

In the joint model, combined administration of Agilirose ® and collagen 

demonstrated superior efficacy compared with either compound 

alone. Sub-additive doses achieved equivalent or enhanced 

outcomes, with significant increases in chondrocyte-driven collagen 

type II and proteoglycan synthesis, reflecting improved cartilage 

matrix formation. Concurrently, the combination reduced inflammatory 

cytokines (IL-1β, TNF-α, IL-6) beyond the effect observed with 

individual agents, indicating an amplified anti-inflammatory synergy. 

In dermal applications, in vitro and clinical data showed that 

Agilirose ® influences genes responsible for the synthesis of collagen 

in the skin and potentiates the effects of collagen peptides, producing 

marked improvements in hydration, firmness, barrier integrity, and 

dermal density — parameters less responsive to collagen alone 

(Suarez, 2025, Wollenweber 2025). 

Collectively, these findings suggest that Agilirose ® complements collagen’s 

structural role with targeted biochemical regulation, yielding a 

dual-action approach to joint and skin health. 

Research highlights – Efficacy backed by studies 

Joint Health - Clinical Evidence: The synergistic MotionPlus concept 

(Agilirose ® + hydrolyzed collagen) has been tested in humans in 



Fig. 6: Agilirose ® increases the production of collagen up to 40% in comparison 

to control (collagen hydrolysate alone) showing a synergistic effect. 

a multicenter observational study with over 100 participants with 

osteoarthritis (Fifty to seventy years old). A daily supplementation 

with 0.5 g Agilirose ® plus 5 g collagen for 12 weeks yielded significant 

improvements. Participants’ knee pain scores (WOMAC pain) 

dropped steadily – by 8 weeks the reduction was statistically significant, 

and by 12 weeks pain had declined by nearly 7.5 points (on 

a 0–20 scale) from baseline on average (Feistel 2012). This translated 

to better daily function: WOMAC assessments of physical function 

in the joints showed marked improvement, as illustrated by a 

continual rise in scores of joint flexibility and mobility over the course 

of the study. 

Moreover, participants experienced relief faster than with standard 

supplements. Historically, standalone collagen hydrolysate requires 

3–6 months for benefits to manifest, and rosehip powder alone 

around 3 months. But with Agilirose ® , participants saw meaningful 

pain reduction in just 4–8 weeks – effectively cutting the onset 

time by at least a month. This early benefit is a crucial advantage 

for consumers. Furthermore, the combination allowed participants 

to reduce their use of rescue pain medications (NSAIDs/opioids) 

by 15 %, indicating real-world relief. At study’s end, nearly 80 % of 

participants rated their joint condition as “good” or “very good,” a 

significant improvement in quality of life. Although this was an openlabel 

study, it provided strong validation of Agilirose ® ’s efficacy and 

laid the groundwork for its use as a joint health solution. 

Skin Beauty - Clinical Evidence: Agilirose ® has also undergone 

a placebo-controlled skin health trial. In this double-blind study, 

66 women aged 45–65 with signs of dry, aging skin took either a 

daily nutricosmetic drink (0.5 g Agilirose ® + 2.5 g ® collagen ch) or 

a placebo, over 8 weeks. The Agilirose ® group showed statistically 

significant improvements in multiple skin parameters, validating its 

“beauty-from-within” claims. Skin hydration (measured by corneometry) 

increased by about 9 % after 4 weeks and continued to improve 

to +18 % by week 8. In contrast, the placebo group saw no change, 

highlighting that the active supplement was driving the moisture 

boost. Meanwhile, the Transepi dermal Water Loss (TEWL) method 

was used as an indicator of skin barrier integrity; a lower TEWL indicates 

that the skin is retaining moisture better and that the barrier is 

Fig. 7.0+7.1: A significant reduction of WOMAC pain score wa observed 

from week 4. WOMAc pain score of both affected knees. 

Fig. 8: Skin density images from DUB ® SkinScanner showing the improvements 

after 4 weeks and 8 weeks in comparison to placebo 


33


Fig. 9: Skin density improvements after 4 weeks and 8 weeks in comparison 

to placebo 

stronger. Here, a 10 % decrease was observed at 4 weeks and a 16 % 

decrease by 8 weeks in the Agilirose ® group (Suarez 2025). 

Deeper skin layers benefited too: ultrasound measurements found a 

+19 % increase in dermal density after 4 weeks, reaching +37 % at 

8 weeks. This redensification reflects improvements in the collagenrich 

dermal matrix, correlating with firmer, plumper skin. Consis tently, 

skin elasticity and firmness parameters (via Cutometer) showed 

around 8 % improvement at 4 weeks and 16 % at 8 weeks – meaning 

skin was measurably more elastic and toned in just two months. 

These objective findings were reinforced by women’s own observations. 

By the end of the trial a vast majority of women in the supplemented 

group felt that their skin condition had improved: 74 % 

noticed better moisturization, 58 % noted a stronger skin barrier 

(less dryness and irritation), 90 % perceived their skin to be denser, 

and 63 % reported that it felt firmer. These self-assessments mirror 

the instrumental data and confirm that the benefits were tangible 

in everyday life, such as smoother, more elastic skin. Such a broad 

spectrum of efficacy – hydration, barrier function, dermal structure, 

elasticity – underscores Agilirose ® ’s role as a comprehensive 

nutricosmetic ingredient. It addresses many aspects of skin aging, 

strengthens and rejuvenates the skin on multiple fronts. Importantly, 

no adverse effects were reported, supporting its safety for regular use. 

At a Glance – Key Benefits of Agilirose ® 

• Dual Action: Simultaneously supports joint health (mobility, 

comfort) and skin health (hydration, firmness, elasticity) from 

within, making it a unique 2-in-1 “beauty-from-within” and joint 

solution. 

• Anti-Inflammatory & Antioxidant: Rich in polyphenols that reduce 

inflammation (lowering cytokines like IL-1β, TNF-α, IL-6) and 

combat oxidative stress, thereby protecting cartilage from degradation 

and skin from aging damage. 

• Cartilage & Bone Protection: Slows joint cartilage breakdown by 

inhibiting MMP-1 and MMP-3 enzymes. Inhibits RANKL pathways, 

potentially reducing osteoclast activity and supporting bone integrity 

in joints. 

• Skin Rejuvenation: Enhances collagen production and skin density, 

improves epidermal barrier function (↓TEWL), and increases moisture 

retention for smoother, more elastic skin. 

• Proven Synergy with Collagen: When used alongside collagen 

peptides, Agilirose ® amplifies the benefits – accelerating joint 

comfort improvements and expanding skin benefits. The combination 

yields faster pain relief and broader skin improvements than 

either alone. 

• Clinical Validation: Backed by human studies showing significant 

joint pain reduction (within 8 weeks) and skin hydration & firmness 

gains (within 4–8 weeks) with daily use. Also supported by in vitro 

and pilot trials confirming its mechanisms and efficacy. 

• Clean-Label & Formulator-Friendly: 100 % natural, water-soluble 

powder and clean label compliance (native rosehip extract and 

collagen peptides). No artificial additives, non-GMO, and easy to 

integrate into various supplements and functional food formats. 

• Patented & Quality Assured: Produced under a patent-protected 

process. Reliable sourcing and consistent standardization ensure 

reproducible results in finished products. 

Applications and formulation ideas 

Agilirose ® opens the door for innovative product development in the 

dietary supplement, functional food in the beauty and joint nutrition 

sectors. Its versatility and neutral taste allow it to be incorporated into 

numerous delivery forms: from convenient instant drink powders and 

effervescent tablets to flavorful gummies, capsules, or sachets. For 

example, it can be featured in a once-daily sachet that consumers 

mix into water or a smoothie — providing a pleasant-tasting beverage 

that nourishes their joints and skin simultaneously. Given its water 

solubility, it can also enrich collagen drink shots, protein blends, 

or even powdered stick packs targeting active adults seeking both 

mobility and maintaining a healthy appearance. 

From a formulation perspective, Agilirose ® conveniently already 

includes collagen peptides as part of its composition. This pre-combination 

ensures optimal performance when formulating collagenbased 

products, making easier to incorporate and eliminating the 

need for additional drying aids. The recommended daily dose (tested 

in studies) is 0.5 g of Agilirose ® and manufacturers can use Agilirose ® 

as a single, turnkey ingredient sourcing of anti-inflammatory and antioxidant 

bioactive substances, or they can add additional collagen if 

desired to deliver this synergistic combo. It also combines well with 

other actives common in joint and skin formulas: for instance, hyaluronic 

acid, vitamin C, biotin, or glucosamine could be included alongside 

to further boost efficacy and market appeal. 

From a marketing perspective, Agilirose ® allows brands to position 

products in the emerging “inside-out wellness” category. The concept 

of caring for one’s joints and skin together resonates with the idea 



of holistic aging gracefully. By emphasizing 

Agilirose ® ’s natural origin (wild rosehips) and 

scientific backing, companies can create 

compelling storytelling for their customers. 

Conclusion – A new generation of 

wellness ingredient 

Agilirose ® exemplifies the innovation 

happening in the wellness industry – a 

botanical extract that marries the wisdom 

of traditional herbal use with the demands 

of modern evidence-based nutraceuticals. 

It offers a harmonious solution to two major 

consumer concerns: staying active and 

maintaining a youthful appearance. For the 

consumer, that means less pill overload (one 

ingredient addressing multiple needs) and 

confidence in results thanks to clinical validation. 

For product developers, Agilirose ® 

provides a unique selling proposition: dualbenefit 

functionality supported by robust 

research, and ease of formulation due to its 

stability and solubility. 

In an era where people seek to “live longer, 

live better”, Agilirose ® delivers on both fronts 

– helping to keep joints flexible for physical 

freedom and skin nourished for a vibrant 

look. As more studies and success stories 

emerge, Agilirose ® is poised to become a 

flagship ingredient in the joint/beauty crossover 

category. In summary, this rosehip 

extract is far more than a traditional remedy 

– it’s a scientifically crafted wellness champion 

that proves the point: when it comes 

to aging well, taking care of what’s inside 

reflects on the outside. Agilirose ® truly brings 

new meaning to the phrase “healthy aging,” 

giving consumers the freedom to move with 

ease and glow with confidence at any age. 

References 

Appel K, Feistel B, Walbroel B, Munoz E. Rose hip special extract FB9440 inhibited 

osteoclastogenesis via NF-κB pathway. Planta Med. 2013;79(Suppl 3):PM3. 

doi:10.1055/s-0033-1352336. 

Ayati Z, Amiri MS, Ramezani M, Delshad E, Sahebkar A, Emami SA. Phytochemistry, 

Traditional Uses and Pharmacological Profile of Rose Hip: A Review. Curr Pharm Des. 

2018;24(35):4101-4124. doi: 10.2174/1381612824666181010151849.. 

Feistel B, Suarez CG, Bender C. Efficacy and bioavailability of rose hip peels extract bioactive 

compounds for joint health after mimicking human digestive conditions. Phytochemistry 

Letters., 2025, Vol 69, 103956. doi:10.1016/j.phytol.2025.103956 

Kayahan, S., Ozdemir, Y. & Gulbag, F. Functional Compounds and Antioxidant Activity of 

Rosa Species Grown in Turkey. Erwerbs-Obstbau 65, 1079–1086 (2023). doi:10.1007/ 

s10341-022-00688-5 

Kılıçgün H, Altıner D. Correlation between antioxidant effect mechanisms and polyphenol 

content of Rosa canina. Pharmacogn Mag. 2010 Jul;6(23):238-41. doi: 10.4103/0973- 

1296.66943 

Koczka N, Stefanovits-Bányai É, Ombódi A. Total Polyphenol Content and Antioxidant 

Capacity of Rosehips of Some Rosa Species. Medicines (Basel). 2018 Aug 4;5(3):84. doi: 

10.3390/medicines5030084. 

Shembekar A, Chaple D, Thakre R, Bhagat R, Chahare N, Durge M. Rosehip (Rosa Canina 

L.): A Systematic Review of The Plant, Traditional Uses, And Pharmacological Aspect. Int. J. 

of Pharm. Sci., 2025, Vol 3, Issue 2, 1513-1519. 

Suárez CG, Wollenweber U. Redensify, Rehydrate, Rejuvenate: Clinical Insights on 

AGILIROSE ® BEAUTY. EuroCosmetics. 2025 May;33(5):2–5. 

Walbroel B, Conrad F, Feistel B. Rose hip extract preparation – New research results in 

humans. Presented at the congress: Bayern Innovativ – Natürliche Inhaltsstoffe; 20 October 

2011; Traunreut, Germany. 

Walbroel B, Feistel B. A new refined Rose hip extract and its anti-arthritic potential. 

Zeitschrift für Phytotherapie 2009b; 30 – P47 Doi: 10.1055/s-0029-1239932 

Walbroel B, Feistel B, Pischel I. Preparations with rosehip extracts, and method of producing 

rosehip extracts. WO2009080778A2. 2009a [Jul 2]. 

Wollenweber U, Suarez CG, Feistel B, Bender C. A cutting-edge transcriptomic dive into 

the beauty benefits of rosehip extract. Presented at: IFSCC 2025 Congress; 2025; Cannes, 

France. Full paper No. 1484. 

Acknowledgement: 

We thank our late colleague Dr. Björn Feistel for his extraordinary 

contributions to this project. 

Photo © : Adobe Stock/F vencav 


The Authors: 

Ralf Spreemann 1 , Andressa Blainski 1 , 

Cynthia G. Suarez 1, *, Ivo Pischel 2 

1 

Martin Bauer GmbH, 

Koblenzer Str. 48 – 56, 

56626 Andernach, Germany 

2 

Dr. Ivo Pischel Consulting, 

Lacher Weg 1, 53547 Rossbach, Germany 

*Corresponding author: Cynthia G. Suarez; 

cynthia.suarez-rizzo@martin-bauer.com 


35

Skin health 

Photo © : Adobe Stock/F Fizur 

Pycnogenol ® for smooth skin 

Dr. Franziska Weichmann 

Skin health is increasingly recognized as a reflection of 

overall physiological balance rather than a purely cosmetic 

concern. Beyond topical care, oral approaches can support 

the skin from within by addressing key factors such as hydration, 

elasticity and structural resilience across the entire 

body. Healthy skin is well hydrated and shows a high level 

of elasticity to be able to better deal with external stress 

such as sun radiation, air pollution or body changes such as 

weight fluctuation or aging. 

An ever-increasing number of clinical studies demonstrate the efficacy 

of Pycnogenol ® French maritime pine bark extract for skin 

health and beauty. This includes increased skin elasticity, skin hydration, 

reinforced skin barrier function and decreased skin fatigue 

(1-5), as well as improved microcirculation and blood flow (6-11). 

In addition, Pycnogenol ® was recently shown to have beneficial effects 

on cellulite severity and skin smoothness (12) as well as symptoms 

of lipedema such as swollen, heavy and bruised legs (13). Moreover, 

Pycnogenol ® supplementation contributes to skin health and beauty 

by helping to reduce melasma development and minimize the effects 

of photo-ageing (1, 5, 14-18). 

Pycnogenol ® improves skin hydration and elasticity 

Skin firmness and hydration depend largely on the body’s ability 

to produce and preserve collagen, elastin and hyaluronic acid. 

Supporting these processes helps maintain skin elasticity, moisture 

and resistance to daily environmental stress. 


Skin health 

For instance, collagens make up over 

30 % of the extracellular matrix, acting as 

supportive tissue material and bringing 

stability and elasticity (19). Elastin, which 

together with fibrillin microfibrils make up 

elastic fibers, is crucial for elasticity and 

extensibility of various tissues, including 

the skin (19). Another important component 

of the extracellular matrix is hyaluronic 

acid, which contributes to water 

retention in tissues and to their structural 

integrity (19). 

Clinical investigations of Pycnogenol ® 

supplementation for 3 months with healthy 

female volunteers, aged 55 to 68 years 

revealed significantly increased expression 

of hyaluronic acid synthase within the skin 

by 44 %, leading to youthful, hydrated, and 

resilient skin (2). Hyaluronic acid synthase 

is the natural source of water-binding hyaluronic 

acid in the dermis, which moisturizes 

the skin and keeps it taut and smooth, 

and it supports the structural integrity of 

the extracellular matrix by interacting with 

collagen and elastin fibers. Additionally, 

Pycnogenol ® was shown to stimulate the 

synthesis of new collagen – skin´s connective 

tissue – by increasing its expression in 

average by 40 % (2). 

In addition, Pycnogenol ® was shown to 

reduce the release and activity of destructive 

enzymes (metalloproteinases 1,2 

and 9), which break down dermal tissue 

proteins, like collagen or elastin (3, 4). 

The reduced activity of these lytic enzymes 

saves the connective tissues from degradation, 

representing the basis for maintaining an elastic and youthfullooking 

skin. By increasing hyaluronic acid and collagen production 

within the body and protecting elastin and collagen from being 

degraded, Pycnogenol ® was shown to increase skin elasticity and 

skin hydration (1-5). 

In the 3-month study with 20 women, mentioned earlier, a significant 

skin-hydration increase by 21 % in the Pycnogenol ® group 

was found, particularly in women presenting with dry skin prior to 

Pycnogenol ® intake (2). It was also shown to improve skin elasticity 

by 25 % and decrease skin fatigue by 30 %. In addition, it was 

observed that Pycnogenol ® supplementation reduced skin wrinkles 

by 3 % and increased skin smoothness by 6 %. 

In another study with 78 subjects, who work outdoors in an urban 

area, skin elasticity was shown to be improved with Pycnogenol ® 

by 13 % after 3 months, compared to an increase of 1 % in the 

placebo group (1). In this placebo-controlled double-blind study, 

Pycnogenol ® reduced water loss of the skin (trans-epithelial water 

loss) during the hot summer season by 14 %, whereas it only reduced 

by 5 % with placebo. This prevented skin moisture decrease during 

the hot summer season. Skin moisture was reduced by only 3.3 % 

with Pycnogenol ® , while with placebo it was reduced by 14 % after 3 

months. This shows that the intake of Pycnogenol ® reinforced skin 

barrier function. 

Another finding that supports Pycnogenol ® ’s positive effects on skin 

barrier function, was an increased expression of genes involved in 

keratinocyte differentiation and barrier formation including loricrin, 

indicating that Pycnogenol ® supplementation was associated with 

an improved formation of cornified envelopes and thus preserve 

skin hydration by reducing trans-epithelial water loss (5). In addition, 

healthy blood flow is essential to sufficiently nurture the skin 

from within. Blood vessels bring oxygen and nutrients through 

arteries and small microvessels all over the body, providing beneficial 

effects from head to toe. Pycnogenol ® helps to optimize blood 

flow by regulating microcirculation (6-8) and blood flow (9-11), 

which is crucial for skin and overall health. 


37

Skin health 

Pycnogenol ® reduces melasma development and limits 

photo-ageing 

In addition to its effects on skin hydration and elasticity, Pycnogenol ® 

was shown to provide potent photo-protective and melasma-reducing 

effects from the inside out, contributing to an even skin tone (1, 5, 

14-18). Melasma is a common form of hyperpigmentation and may 

be caused by UV exposure, female hormones or by predisposed 

genetic background (20). In clinical studies, Pycnogenol ® reduced 

the area and intensity of melasma and led to a more regular and even 

skin complexion (1, 16, 17). 

A study with 30 women with melasma reported a more regular and 

even skin complexion with 22 % lower pigment intensity following 

four weeks intake of Pycnogenol ® (17). Additionally, it was shown to 

effectively decrease the area of over-pigmented skin spots by 38 %, 

leading to smaller spots. 

It was shown that Pycnogenol ® suppresses tyrosinase activity, an 

enzyme that activates the production of melanin – the pigments, 

responsible for melasma (14, 15). These findings of Pycnogenol ® ’s 

ability to counteract skin hyperpigmentation were clinically validated 

in a study, in which Pycnogenol ® was shown to significantly lower 

UV-induced expression of enzymes that are linked to long-lasting 

pigmentation (5). It was further shown to increase the resistance of 

participant’s skin to solar UV exposure, needed to trigger skin redness 

(18). The results from these studies suggest that Pycnogenol ® has 

photo-protective and melasma-alleviating efficacies. 

Beautiful legs with Pycnogenol ® 

Beautiful legs have been celebrated throughout history, admired in 

art, fashion, and culture as symbols of grace and strength. More than 

just an aesthetic ideal, healthy legs are often a testament to physi cal 

well-being and an active lifestyle. Conditions that alter the ideal silhouette 

of a “perfect” leg, like lipedema or cellulite are affecting mostly 

women. Pycnogenol ® French maritime pine 

bark extract as part of a healthy lifestyle has 

shown to contribute to more beautiful and 

healthy legs. 

Newly published study shows 

Pycnogenol ® ’s effects on lipedema 

A recently published clinical study investigated 

the effects of Pycnogenol ® supplementation 

on key symptoms of lipedema, 

a chronic condition that significantly affects 

quality of life in women (13). Lipedema 

causes an abnormal build-up of subcutaneous 

fat in the legs and sometimes arms 

that is not caused by obesity and is resistant 

to traditional diet and exercise (21). The 

condition can be painful and depending on 

the severity, can greatly affect mental wellbeing 

and daily life. Often misdiagnosed, 

the cause of lipedema is still unknown and 

unfortunately, there is no consensus treatment 

described, apart from lymph drainage, 

compression and physiotherapy to manage 

the condition. 

In the study, one hundred women in their 

thirties with diagnosed lipedema took 

Pycnogenol ® or placebo for 2 months (13). 

The lipedema-related symptom score was 

reduced by a surprising 29 % compared to 

baseline and was significantly reduced by 

32 % compared to placebo at the end of the 

study. In the lipedema-specific questionnaire 

on quality of life that was used, several 

parameters were significantly reduced, such 


Skin health 

as swelling of the legs, heavy legs, tenderness 

and bruising. In addition, an 8 % reduction 

in body fat and a significant improvement 

in satisfaction with leg appearance 

and quality of life compared to placebo was 

reported at the end of the study. 

Pycnogenol ® ’s benefits on Lipedema stem 

from its antioxidant (9, 22-27) and antiinflammatory 

properties (4, 28, 29), which 

help strengthen blood vessel walls (9-11) 

and improve microcirculation (6-8). These 

effects are particularly relevant for lipedema, 

where impaired circulation contributes to 

chronic swelling and tissue discomfort. 

Pycnogenol ® ’s efficacy on cellulite 

Cellulite is a very common cosmetic skin 

condition of the legs, affecting 80-90 % of 

women (30). It is linked to dermal structure 

and vascular changes, causing subcutaneous 

fat within connective tissue to push up the 

skin leading to dimpled and bumpy skin on 

the thighs, hips, buttocks and abdomen (30). 

A recent study revealed that Pycnogenol ® 

significantly decreases cellulite severity 

(12). The double-blind placebo-controlled 

study included 60 women who either took 

Pycnogenol ® or placebo for 3 months. Cellulite 

severity was significantly reduced by 

13.6 % in the Pycnogenol ® group, according to the Hexsel cellulite 

severity score, a clinically valuated assessment tool, evaluating five 

key morphological features of cellulite, such as skin surface alterations 

and sagging skin. In addition, upper thigh circumference was 

significantly reduced by 2.07 cm after the 3 months of Pycnogenol ® 

intake compared to a reduction of 0.9 cm in the placebo group. 

Skin roughness was decreased by 32 % and skin smoothness was 

increased by 11.2 % after Pycnogenol ® supplementation. 

Pycnogenol ® French maritime pine bark extract is a safe, natural 

and evidence-based solution to support smooth and healthy skin. 

Pycnogenol ® improves skin hydration and skin elasticity and reduces 

skin fatigue. Additionally, Pycnogenol ® provides photo-protection and 

reduces melasma, contributing to an even and healthy skin tone. 

New research shows that Pycnogenol ® not only helps to increase leg 

beauty but also reduces the symptoms of lipedema and cellulite. 

References 

1. Zhao H, et al. Skin Pharmacol Physiol. 2021;34(3):135-45. 

2. Marini A, et al. Skin Pharmacol Physiol. 2012;25(2):86-92. 

3. Grimm T, et al. Free Radic Biol Med. 2004;36(6):811-22. 

4. Grimm T, et al. J Inflamm (Lond). 2006;3:1. 

5. Grether-Beck S, et al. Skin Pharmacol Physiol. 2016;29(1):13-7. 

6. Wang S, et al. European Bulletin of Drug Research. 1999;7(2):19-25. 

7. Belcaro G, et al. Clin Appl Thromb Hemost. 2006;12(3):318-23. 

8. de Souza Lima Hara WY. Rio de Janeiro: State University of Rio de Janeiro; 2023. 

9. Enseleit F, et al. Eur Heart J. 2012;33(13):1589-97. 

10. Nishioka K, et al. Hypertens Res. 2007;30(9):775-80. 

11. Zibadi S, et al. Nutr Res. 2008;28(5):315-20. 

12. Liu Q, et al. Phytomedicine Plus. 2025;5(3):100821. 

13. Seabra De Mello Netto BA, et al. Jornal Vascular Brasileiro. 2025. 

14. Kim YJ, et al. Food Chem Toxicol. 2008;46(7):2466-71. 

15. Leis Ayres E, et al. J Cosmet Dermatol. 2022;21(3):1234-42. 

16. Pinto CAS, et al. Surgical & Cosmetic Dermatology. 2015;7(3):218-22. 

17. Ni Z, et al. Phytother Res. 2002;16(6):567-71. 

18. Saliou C, et al. Free Radic Biol Med. 2001;30(2):154-60. 

19. Karamanos NK, et al. The FEBS Journal. 2021;288(24):6850-912. 

20. Kwon SH, et al. Experimental Dermatology. 2019;28(6):704-8. 

21. Kruppa P, et al. Dtsch Arztebl Int. 2020;117(22-23):396-403. 

22. Ryan J, et al. J Psychopharmacol. 2008;22(5):553-62. 

23. Chovanova Z, et al. Free Radic Res. 2006;40(9):1003-10. 

24. Ďuračková Z, et al. Nutrition Research. 2003;23(9):1189-98. 

25. Devaraj S, et al. Lipids. 2002;37(10):931-4. 

26. Kolacek M, et al. Free Radic Res. 2013;47(8):624-34. 

27. Yang HM, et al. Acta Obstet Gynecol Scand. 2007;86(8):978-85. 

28. Canali R, et al. Int Immunopharmacol. 2009;9(10):1145-9. 

29. Schäfer A, et al. Biomed Pharmacother. 2005;60(1):5-9. 

30. Gabriel A, et al. Aesthetic Surgery Journal Open Forum. 2023;5:1-13. 


Dr. Franziska Weichmann, 

Manager of Scientific Communications 

and Product Development at 

Horphag Research 

www.pycnogenol.com 


39


SelectSIEVE ® HopE: a supercritical CO 2 

– 

derived Hop phytocomplex for metabolic 

syndrome support 

Samuele Selva 

From the forefront of ROELMI HPC research comes 

SelectSIEVE ® HopE, a synergy of hop phytocomplex components 

developed through advanced supercritical CO 2 

extraction 

technology and carefully processed into a stable, easyto-handle 

powder form. It is designed to support metabolic 

health, particularly in the context of metabolic syndrome and 

its efficacy has been demonstrated in preclinical studies, 

delivering promising and noteworthy results that highlight its 

potential in metabolic support strategies. 

Biological target & ingredient design rationale 

Metabolic syndrome is a broad and multifactorial clinical condition, 

encompassing metabolic, cardiovascular, and inflammatory 

alterations that collectively impair overall health and long-term wellbeing. 

Throughout adult life, lifestyle habits, hormonal changes, and 

genetic predisposition interact and may progressively affect metabolic 

balance and body composition, leading 

to the onset of this particularly critical condition, 

characterized by the coexistence of 

central obesity, insulin resistance, hypertension, 

and dyslipidemia 1 . 

These alterations reflect a profound disruption 

of metabolic homeostasis and are associated 

with an increased risk of type 2 diabetes 

and cardiovascular disease. Chronic energy 

imbalance, excessive caloric intake, poor 

dietary quality, and sedentary behavior play 

a central role in its development, often in 

combination with genetic susceptibility. 

During the progression of metabolic 

syndrome, adipose tissue dysfunction con- 



tributes to low-grade chronic inflammation, 

endothelial impairment, and altered 

glucose and lipid metabolism 2 . Common 

clinical manifestations include increased 

waist circumference, elevated fasting 

glucose, high triglycerides, low HDL cholesterol 

levels, and elevated blood pressure, 

all of which significantly increase cardiometabolic 

risk 3 . Epidemiological data indicate 

that the global prevalence of metabolic 

syndrome has risen dramatically over the 

past two decades, with nearly one-third of 

the adult population meeting the diagnostic 

criteria (approximately 1.54 billion adults 

worldwide, corresponding to 28–31 % of 

the global adult population) in 2023. Alarmingly, 

an increasing incidence is also being 

reported in pediatric and adolescent populations, 

largely driven by childhood obesity, 

sedentary behavior, and poor dietary habits. 

Projections indicate a continued upward 

trend across all age groups, fueled by population 

aging and the persistence of unhealthy 

lifestyle patterns 4 . First-line management 

strategies focus on long-term lifestyle interventions, 

including dietary modification, antiobesity 

drugs (or even weight-loss surgery), 

and increased physical activity. 

Hop phytocomplex: mechanistic evidence 

The first step in the development was a structured bibliographic 

review conducted by ROELMI HPC, which identified the hop phytocomplex 

as a particularly promising source of bioactive molecules 

capable of modulating key metabolic pathways involved in the pathophysiology 

of metabolic syndrome. Among the most relevant constituents 

are α-acids (humulone derivatives), β-acids (lupulone derivatives), 

and especially their isomerized forms, the iso-α-acids (isohumulones), 

which emerge as central mediators of the metabolic activity 

attributed to hop extracts. 

At the intestinal level, hop bitter acids function as ligands of TAS2R 

(bitter taste receptors) expressed on enteroendocrine cells lining the 

gastrointestinal tract. Activation of these receptors triggers intracellular 

signaling cascades that promote the secretion of metabolically 

active gut peptides. A randomized, double-blind, crossover clinical 

trial demonstrated that a supercritical CO 2 

hop extract significantly 

increased postprandial levels of GLP-1, CCK, and PYY, while modulating 

ghrelin dynamics and reducing total energy intake in healthyweight 

men 7 . 

These gut-derived hormones play a central role in the regulation 

of appetite, satiety, gastric emptying, and glycemic control: GLP-1 

When necessary, pharmacological treatments 

targeting individual components (such as 

antihypertensive, lipid-lowering, or glucoselowering 

agents) may be prescribed. However, 

given the complex and multifactorial nature of 

metabolic syndrome, integrated and comprehensive 

approaches are increasingly recognized 

as essential for effective management 5,6 . 

In this context, SelectSIEVE ® HopE by 

ROELMI HPC may represent a targeted, 

multifactorial nutritional strategy. This technologically 

advanced powdered hop extract, 

obtained through supercritical CO 2 

extraction, 

standardized in α- and β-acids, iso-αacids, 

β-caryophyllene, and xanthohumol, 

acts along the gut–liver axis to address 

several core components of metabolic 

syndrome simultaneously. Through an integrated 

mechanism of action, SelectSIEVE ® 

HopE proposes a comprehensive approach 

to managing the complex and multifaceted 

pathophysiology of metabolic syndrome. 


41


enhances insulin secretion and supports glucose homeostasis, CCK 

and PYY promote early satiety and reduced caloric intake, and the 

modulation of ghrelin contributes to balanced hunger signaling 

and overall energy intake regulation. Together, this TAS2R-mediated 

“bitter brake” mechanism represents a physiologically coherent 

strategy to counteract hyperphagia, postprandial glycemic excursions, 

and progressive weight gain, which are core features of metabolic 

syndrome 8,9 . 

Complementing this enteric mechanism, iso-α-acids exert 

systemic metabolic effects through activation of the nuclear receptors 

PPAR-α and PPAR-γ. The activation of α isoform supports 

lipid catabolism and improved plasma lipid profiles, while the 

modulation of PPAR-γ enhances insulin sensitivity and promotes 

healthier adipose tissue remodeling without the marked weight 

gain often associated with synthetic agonists. In vitro and in vivo 

studies found in the literature have shown results consistent with 

the agonist behavior of isoumulones on both receptors: in diabetic 

animal models fed a high-fat diet, treatment with isoumulones 

significantly reduced plasma glucose, triglycerides, and free fatty 

acids, improved insulin sensitivity, enhanced hepatic fatty acid 

oxidation, and reduced adipocyte hypertrophy 10,11,12,13 . Importantly, 

a pilot clinical trial also reported reductions in fasting glucose and 

HbA1c following supplementation 14 . 

Taken together, the evidence supports a dual and synergistic mechanism: 

intestinal TAS2R activation reduces appetite and improves 

satiety and glycemic regulation through the modulation of incretin 

responses, while hepatic and adipose PPAR modulation addresses 

dyslipidemia and insulin resistance. This integrated gut–liver axis 

approach provides a robust scientific foundation for positioning hop 

phytocomplex components as a multifactorial strategy against the 

complex and interconnected drivers of metabolic syndrome. 

Technological development of selectSIEVE ® HopE 

Backed by these robust bibliographic evidence supporting the efficacy 

of the hop phytocomplex in the management of metabolic 

syndrome, the company ROELMI HPC undertook the development 

of a standardized nutraceutical active ingredient designed to deliver 

all bioactive components of interest in a technologically advanced 

and stable form. 

The selected raw material was a sustainable supercritical CO 2 

extract 

obtained from the cones (female inflorescences) of Humulus lupulus. 

This extract, naturally appearing as a viscous resin, represents a 

highly concentrated source of lipophilic hop constituents. Part of this 

extract was used as such to obtain the first functional component of 

the finished ingredient. For the second component, the α-acid fraction 

underwent an additional technological transformation: through a 

controlled high-temperature aqueous process, α-acids were isomerized 

into iso-α-acids (isohumulones), subsequently stabilized in the 

form of a potassium salt solution. 

Both fractions, initially in liquid form, were 

then subjected to proprietary spray-drying 

processes specifically developed to adsorb 

and stabilize the active compounds onto 

suitable carriers. This technological step 

enabled the conversion of the liquid bases 

into stable, free-flowing powders compliant 

with current nutraceutical quality and regulatory 

standards, while preserving the integrity 

and bioactivity of the key molecules. 

The final ingredient, branded as SelectSIEVE ® 

HopE, results from the combination of these 

two complementary components. It provides 

the full lipophilic spectrum of the hop 

phytocomplex (including α- and β-acids, 

β-caryophyllene, and prenylated flavonoids) 

together with the standardized isomerized 

fraction of α-acids (isohumulones), known 

for their metabolic activity. 

The ingredient has been carefully titrated so 

that a daily dose of 200 mg delivers a clinically 

relevant amount of bioactive compounds, 

consistent with the levels supported by 

scientific evidence for metabolic support. Its 

powdered form and technological stability 

make SelectSIEVE ® HopE suitable for incorporation 

into standard pharmaceutical 

dosage forms, including capsules, tablets, 

sticks, and sachets, ensuring formulation 

flexibility and ease of use. 

Efficacy dossier & synergy hypothesis 

Once the finished ingredient was obtained, 

the next step was, naturally, to demonstrate 

its potential efficacy and validate its mechanism 

of action through robust preclinical 

testing. The first phase of the in vitro trial 

involved simulated digestion of the ingredient, 

using a patented method: systemic 

exposure was simulated through a standardized 

in vitro digestion and absorption model 

reproducing oral administration and gastrointestinal 

transit. 

Test samples, whose quantities mimicked the 

actual daily amount administered (component 

A, component B, and SelectSIEVE ® 

HopE) were dispersed in distilled water 

and subjected to sequential gastric and 

intestinal digestion. The gastric phase was 



performed by adding pepsin and adjusting 

to acidic pH, followed by incubation at 37 °C 

for 1 hour under agitation. The intestinal 

phase was then simulated by adding bile 

salts and pancreatin, adjusting to a neutral 

to basic pH, and incubating for an additional 

2 hours. The resulting digests were 

applied to reconstructed human intestinal 

epithelium cultured in a transwell system 

to mimic transepithelial absorption and 

systemic exposure. After 24 hours, medium 

was collected and transferred to human 

hepatocytes for a further 24-hour incubation. 

Biological endpoints were assessed in 

comparison with negative controls. On the 

intestinal epithelium, GLP-1, cholecystokinin 

(CCK) and peptide YY (PYY) release were 

measured. On hepatocytes, PPAR-α activation 

and PPAR-γ were evaluated. 

cystokinin (CCK), with SelectSIEVE ® HopE inducing the highest 

increase among the tested samples (+98.40 % vs CTR-), highlighting 

its strong potential to promote satiety signaling. Additionally, peptide 

YY (PYY) levels were significantly elevated (+21.66 % vs CTR-, further 

supporting its role in the modulation of gut-derived anorexigenic 

hormones. Overall, these results indicate that SelectSIEVE ® HopE 

effectively enhances the secretion of key gastrointestinal peptides 

involved in appetite regulation and metabolic homeostasis under 

simulated digestive and absorptive conditions. 

Fig. 2: variation vs negative control *p


In vivo, activation of PPAR-α is associated with enhanced hepatic 

fatty acid oxidation, reduction of circulating triglycerides, and overall 

improvement of lipid metabolism. Concurrent activation of PPAR-γ is 

linked to improved insulin sensitivity, modulation of adipocyte function, 

better glucose uptake, and more balanced glycemic control. 

Together, the observed upregulation of both PPAR-α and PPAR-γ 

suggests that SelectSIEVE ® HopE may exert a coordinated metabolic 

effect targeting dyslipidemia, insulin resistance, and altered 

glucose homeostasis, key pathophysiological components of metabolic 

syndrome. 

The final step of the investigation aimed to verify the presence of 

a synergistic interaction between the two functional components of 

SelectSIEVE ® HopE. To this end, a mathematical approach based 

on Colby’s equation was applied, using the percentage increases 

observed in CCK release and PPAR-α receptor activation as reference 

endpoints. The analysis demonstrated a true synergistic effect 

between the two fractions composing the ingredient. 

Specifically, the increases induced by SelectSIEVE ® HopE in both 

CCK secretion and PPAR-α activation exceeded the expected algebric 

sum of the effects produced by the individual components 

administered separately15. These findings support the hypothesis 

that the combined formulation enhances biological activity beyond 

simple additivity, confirming the rationale behind the integrated 

design of the ingredient. 

Following the clarification and confirmation of the mechanism of 

action of the ingredient, a double-blind, randomized, placebocontrolled 

clinical trial has been designed to further validate its efficacy 

in humans. The study will enroll subjects meeting the diagnostic 

criteria for metabolic syndrome, including overweight status, 

impaired fasting plasma glucose, and dyslipidemia. 

The trial is structured to evaluate the impact of the nutraceutical 

active ingredient on clinically relevant endpoints associated with 

metabolic syndrome. Primary and secondary outcomes will include 

changes in visceral adiposity, body mass index (BMI), and anthropometric 

parameters, as well as glycated hemoglobin (HbA1c) and 

blood lipid profile (including triglycerides and cholesterol fractions). 

This clinical investigation is intended to provide robust evidence 

supporting the metabolic benefits of SelectSIEVE ® HopE and to 

substantiate its role as a targeted, multifactorial nutraceutical strategy 

for the management of metabolic syndrome. 

Conclusion 

Collectively, these preliminary findings suggest that SelectSIEVE ® 

HopE may exert a broad and clinically meaningful impact in individuals 

with metabolic syndrome. Overall, this coordinated enteric– 

hepatic modulation supports the potential to positively influence 

multiple hallmarks of metabolic syndrome, including hyperglycemia, 

central adiposity, and altered lipid profiles, through an integrated 

and multifactorial mechanism of action. Although clinical validation 

remains essential, these preclinical data highlight a promising 

nutraceutical strategy aimed at restoring metabolic balance rather 

than addressing a single isolated parameter. SelectSIEVE ® HopE 

is currently patent pending, reflecting the innovative nature of its 

composition and proprietary development process. 

Bibliography 

1 

Neeland, I.J., Lim, S., Tchernof, A. et al. Metabolic syndrome. Nat Rev Dis Primers 10, 77 

(2024). https://doi.org/10.1038/s41572-024-00563-5 

2 

Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin North Am. 2014;43(1):1– 

23. doi:10.1016/j.ecl.2013.09.009. 

3 

Han TS, Lean MEJ. Metabolic syndrome. Medicine (Baltimore). 2015;43(2):80–87. 

doi:10.1016/j.mpmed.2014.11.006. 

4 

Noubiap, J.J., Nansseu, J.R., Nyaga, U.F. et al. Worldwide trends in metabolic syndrome 

from 2000 to 2023: a systematic review and modelling analysis. Nat Commun 17, 573 

(2026). https://doi.org/10.1038/s41467-025-67268-5 

5 

oleymani, T., Daniel, S., and Garvey, W. T. (2016) Weight maintenance: challenges, tools 

and strategies for primary care physicians. Obesity Reviews, 17: 81–93. doi: 10.1111/ 

obr.12322. 

6 

Wofford MR, Hall JE. Pathophysiology and treatment of obesity hypertension. Curr Pharm 

Des. 2004;10(29):3621–3637. doi:10.2174/1381612043382855. 

7 

Walker, Edward G., et al. “An extract of hops (Humulus lupulus L.) modulates gut peptide 

hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover 

clinical trial.” The American Journal of Clinical Nutrition 115.3 (2022): 925-940. 

8 

Lela, Ludovica, et al. “Humulus lupulus L.: Evaluation of Phytochemical Profile and Activation 

of Bitter Taste Receptors to Regulate Appetite and Satiety in Intestinal Secretin Tumor 

Cell Line (STC1 Cells).” Molecular Nutrition & Food Research 68.21 (2024): 2400559. 

9 

Walker, Edward, et al. “New Zealand bitter hops extract reduces hunger during a 24 h 

water only fast.” Nutrients 11.11 (2019): 2754. 

10 

Yajima, Hiroaki, et al. “Isohumulones, bitter acids derived from hops, activate both peroxisome 

proliferator-activated receptor α and γ and reduce insulin resistance.” Journal of 

Biological Chemis try 279.32 (2004): 33456-33462. 

11 

Bland, Jeffrey S., et al. “Isohumulones from hops (Humulus lupulus) and their potential 

role in medical nutrition therapy.” PharmaNutrition 3.2 (2015): 46-52. 

12 

Shimura, Masako, et al. “Isohumulones modulate blood lipid status through the activation 

of PPARα.” Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of 

Lipids 1736.1 (2005): 51-60. 

13 

Yajima, H., et al. “Prevention of diet-induced obesity by dietary isomerized hop extract 

containing isohumulones, in rodents.” International journal of obesity 29.8 (2005): 

991-997. 

14 

Obara, Kuniaki, et al. “Isohumulones, the bitter component of beer, improve hyperglycemia 

and decrease body fat in Japanese subjects with prediabetes.” Clinical Nutrition 

28.3 (2009): 278-284. 

15 

Soller, Henning, and A. Wedemeier. “Prediction of synergistic multi-compound mixtures–A 

generalized Colby approach.” Crop Protection 42 (2012): 180-185. 


Samuele Selva, Product Manager, 

ROELMI HPC 

info@roelmihpc.com 

https://www.roelmihpc.com/ 



Photo © : VGstockstudio/Shutterstock 

Beyond GLP-1: ingredients for 

long-term success 

How functional nutrition is shaping the next wave of weight management solutions 

GLP-1 has rapidly moved from a 

clini cal term to a mainstream topic 

that dominates news headlines on a 

daily basis. As a result, many people 

are now familiar with medications 

like Ozempic and Wegovy, which help 

control appetite and support weight 

loss by mimicking the satiety effects of 

natural gut hormones. However, while 

their efficacy is recognised, concerns 

about safety, side-effects, long-term 

results, affordability and dependency 

are impacting consumer behaviour and 

perception. So it is good to know that 

even without these drugs, it’s possible 

to tap into the body’s own ability to regulate 

hunger and satiety. As the market 

matures, a clear shift is emerging: from 

pharmaceutical dependency to nutritional 

strategies that support GLP-1 

pathways naturally and sustainably. 

According to FMCG Gurus research, more than two in three global 

consumers say they are interested in food or beverages that stimulate 

GLP-1 hormones naturally (69 %). 1 For the industry, this opens 

up promising opportunities. Functional ingredients that help modulate 

appetite, stabilise blood glucose and support long-term metabolic 

health are becoming central to innovation strategies – both with and 

without GLP-1 medication. 

From short-term weight loss to long-term health 

Consumer interest in weight management solutions couldn’t be more 

timely: By 2030, nearly 3 billion adults – about half of the global 

adult population – are predicted to be overweight or obese. 2 Both 

conditions are major risk factors for a range of non-communicable 

diseases, from cardiovascular illnesses to type-2-diabetes, putting 

global health systems under increasing pressure. 

GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in 

the gut after eating. It helps regulate blood sugar levels by stimulating 

insulin, suppressing glucagon and slowing digestion. Pharmaceutical 

products, so-called GLP-1 agonists, amplify these effects by reducing 


45


In a ready-to-drink meal replacer, BENEO ingredients can be combined to 

enhance protein and fibre content while reducing glycaemic response and 

supporting natural GLP-1 release. (Picture: AI generated) 

appetite and promoting a feeling of fullness. While GLP-1 medications 

are highly effective in promoting satiety and weight loss, realworld 

experience highlights important limitations. Reduced appetite 

often leads to lower nutrient intake, digestive discomfort, loss of lean 

body mass and low energy. Even more critically, a recent systematic 

review 3 of 37 studies suggests that within 18 months of discontinuing 

weight loss medication, all the lost weight may be regained. On the 

other hand, while those who don’t take such medication typically lose 

less weight, they also regain it more slowly. 

“GLP-1 medication can be an effective catalyst for weight loss, but 

it does not replace the need for a nutritionally balanced, metabolically 

supportive diet,” explains Dr Stephan Theis, Head of Nutrition 

Science and Communication at BENEO. “Long-term success 

depends on supporting the body’s own regulatory systems, especially 

satiety hormones, through everyday foods.” This insight is 

shaping a broader industry trend and has sparked new product 

development: consumers are increasingly looking for food-based 

solutions that help maintain GLP-1 effects naturally – be it during, 

after or without medication. 

Supporting natural GLP-1 release and metabolic stability 

While GLP-1 medications promote feelings of fullness at the 

start, their effect may decline over time. Sustaining satiety and 

supporting the continuous release of natural satiety hormones is 

therefore key for long-term weight management success. Ingredients 

that support metabolic health are needed during this time. For 

many years, BENEO has focused its nutrition research on understanding 

how different functional ingredients can support weight 

management through metabolic pathways, 

including satiety, blood glucose control and 

energy metabolism. Within this extensive 

research portfolio, particular attention has 

been given to Palatinose (isomaltulose). 

As a low-glycaemic, slow-release carbohydrate 

derived from beet sugar, Palatinose 

provides sustained energy while minimising 

post-prandial glucose and insulin peaks. A 

recent human intervention study demonstrated 

that Palatinose intake results in 

a lower blood glucose response compared 

to sucrose, characterised by a significantly 

lower blood glucose peak in adults with 

metabolic syndrome. 4 In parallel, release 

of beneficial gut hormones GLP-1 and PYY 

(peptide tyrosine tyrosine) increased. This 

resulted in a slower and lower blood glucose 

response to lunch, which is described as a 

second-meal effect. Timing also appears to 

matter. The study showed stronger metabolic 

benefits when Palatinose was consumed 

several hours before the next meal – highlighting 

opportunities for functional snacks, 

beverages and supplements designed to fit 

into real-life eating patterns. 

“What makes Palatinose particularly interesting 

in the context of GLP-1 is its ability 

to support hormone release over a longer 

period of time,” says Dr Stephan Theis. “This 

sustained response helps stabilise blood 

glucose across meals and may support 

appetite control well beyond the initial eating 

occasion.” 

But that’s not all: Palatinose TM has also been 

shown to promote fax oxidation which can 

support body composition and weight loss 5 , 

and provide better rehydration and thermoregulation 

in beverages compared to 

sucrose 6 . The latter is an important finding 

as adequate hydration supports metabolic 

and cardiovascular stability, while insufficient 

fluid intake can worsen the side-effects 

of GLP-1 mimetics. 

Proteins for muscle, fibres for satiety 

and beyond 

Every weight loss journey, with or without 

the aid of GLP-1 medication, requires 

reduced calorie intake. With smaller food 



portions, this often means that less nutrients 

are consumed. Nutrient-dense, proteinand 

fibre-rich foods therefore offer a way to 

prevent deficiencies. Protein is key to losing 

fat while preserving lean body mass and 

enhancing satiety: it stimulates the production 

of satiety hormones, which curbs appetite 

and prevents food cravings. Combining 

BENEO’s faba bean and rice proteins 

provides a high-quality plant protein with a 

complete essential amino acid profile. Plus, 

foods and beverages with plant protein tick 

all the boxes for vegans, vegetarians, flexitarians 

and other consumers who want to 

include more plant-based solutions in their 

diet. Manufacturers who combine plantbased 

innovation with weight management 

benefits – for example, with the help of faba 

bean ingredients – can reach new consumer 

groups who want healthy, tasty and environmentally 

responsible food options. 

Dietary fibres play an equally important role in GLP-1-aligned nutrition 

strategies. Orafti ® Inulin and Oligofructose, derived from chicory 

root, are among the few proven prebiotics according to ISAPP (International 

Scientific Association of Probiotics and Prebiotics) 7 and the 

only plant-based ones available. Backed by more than 30 years of 

research, the wealth of scientific data on chicory root fibres includes 

numerous randomised controlled trials. In 2022, this resulted in the 

publication of a systematic literature review with meta-analyses 8 , 

considered to be the most robust methodology in the hierarchy of 

scientific evidence. Its results demonstrated that chicory root fibre 

intake (starting at 3 g/day) promotes significant growth of Bifidobacteria 

in the gut microbiome in all age groups and improves bowel 

function para meters. To examine health benefits beyond the gut, a 

further study applied the same robust approach with 32 randomised 

controlled trials confirming that chicory root fibre intake leads to 

significant reductions in body weight, BMI, fat mass and waist 

circumference, with effects that remain stable – or even increase 

– over time. 9 They trigger a cascade of metabolic effects that help 

promote satiety, thereby helping people to naturally reduce their food 

intake. Inulin and oligofructose can be used in a wide range of food 

and beverage applications, including baked goods, cereals, dairy 

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The application experts at the BENEO-Technology Center have showcased 

such product potential with a plant-based, ready-to-drink chocolate 

meal replacement. Thanks to the inclusion of faba bean protein 

concentrate and Orafti ® Inulin chicory root fibre, a 500 ml serving 

supports satiety and allows for high protein and fibre claims. With the 

addition of BENEO’s low-glycaemic carbohydrate Palatinose, the 

drink also promises a reduced blood glucose response and natural 

GLP-1 stimulation. 

Low-glycaemic carbohydrate Palatinose is derived from sugar beet and 

has been shown to stimulate the body’s own release of the beneficial gut 

hormone GLP-1. Photo © : BENEO 

and snacks. By supporting a healthy gut microbiota and selectively 

promoting the growth of beneficial bacteria, they can improve digestive 

health and relieve discomfort, which is important as many GLP-1 

patients suffer from constipation or diarrhoea. At the same time, 

chicory root fibres allow for improved nutritional profiles by reducing 

sugar or fat content – and thereby calories – while enriching the food 

with dietary fibre. This makes them a versatile ingredient in manufacturers’ 

weight management toolbox. 

From medication support to everyday nutrition 

Looking ahead, experts agree that the most effective GLP-1 strategies 

will not rely on medication alone. Instead, they will integrate pharmacological 

tools with targeted nutrition and lifestyle support. “We are 

moving from a weight-loss conversation to a metabolic health conversation,” 

concludes Dr Stephan Theis. “Functional ingredients that 

support satiety, blood sugar control and gut health will be essential, 

both during and after GLP-1 therapy, to achieve long-term results.” 

Ingredients such as Palatinose and Orafti ® chicory root fibres, as 

well as plant-based proteins, enable manufacturers to develop products 

that support consumers throughout their entire weight management 

journey – thus helping to bridge the gap between medical intervention 

and everyday nutrition. 

As the GLP-1 hype is reinforcing the weight management market, 

the food and drink industry will see rising demand for functional 

products that better support evolving eating habits. No longer just 

a weight loss tool, they are becoming a crucial component of weight 

maintenance, metabolic resilience and long-term health. For brands, 

the opportunity lies in leveraging clinically substantiated ingredients 

that work in harmony with the body’s natural GLP-1 pathways 

– for example, those that support satiety, enhance nutrient density 

in smaller portions, assist blood glucose stability and address digestive 

health. This will turn short-term weight management trends into 

future-proof, holistic nutritional solutions. 

References 

1 

FMCG Gurus – GLP-1 – Diet Food Killer or Market Opportunity – Trend Report 2025 

2 

World Obesity Atlas 2025. London: World Obesity Federation, 2025. https://data.worldobesity.org/publications/?cat=23; 

Overweight BMI >25 kg/m2 

3 

West S. et al (2026). Weight regain after cessation of medication for weight management: 

systematic review and meta-analysis. BMJ 2026; 392 doi: https://doi.org/10.1136/ 

bmj-2025-085304 

4 

Zhang J. et al (2025). Gut Hormones and Postprandial Metabolic Effects of Isomaltulose 

vs. Saccharose Consumption in People with Metabolic Syndrome. Nutrients, 17(15), 2539. 

https://doi.org/10.3390/nu17152539 

5 

Lightowler H. et al (2019) Changes in Weight and Substrate Oxidation in Overweight 

Adults Following Isomaltulose Intake During a 12-Week Weight Loss Intervention: A Randomized, 

Double-Blind, Controlled Trial. Nutrients 11(10). https://www.mdpi.com/2072- 

6643/11/10/2367 

6 

Amano T. et al (2022). Comparison of hydration efficacy of carbohydrate-electrolytes beverages 

consisting of isomaltulose and sucrose in healthy young adults: A randomized crossover 

trial. Physiol Behav; 249:113770. doi: 10.1016/j.physbeh.2022.113770 

7 

Gibson GR, Hutkins R, Sanders ME et al. (2017) Expert consensus document: The International 

Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement 

on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8): 491–502. 

https://www.nature.com/articles/nrgastro.2017.75.pdf See also: https://isappscience.org/ 

8 

Dávid U. Nagy, Kinga Amália Sándor-Bajusz, Blanka Bódy, Tamás Decsi, Jessica Van 

Harsselaar, Stephan Theis & Szimonetta Lohner (2023) Effect of chicory-derived inulintype 

fructans on abundance of Bifidobacterium and on bowel function: a systematic 

review with meta-analyses, Critical Reviews in Food Science and Nutrition, 63:33, 12018- 

12035, DOI: 10.1080/10408398.2022.2098246 

9 

Reimer RA, Theis S, Zanzer YC. The effects of chicory inulin-type fructans supplementation 

on weight management outcomes: systematic review, meta-analysis and meta-regression 

of randomized controlled trials. Am J Clin Nutr. 2024 Sep 21:S0002-9165(24)00751-2. doi: 

10.1016/j.ajcnut.2024.09.019. Epub ahead of print. PMID: 39313030. 


Dr Stephan Theis, 

Head of Nutrition Science 

and Communication, BENEO 

contact@beneo.com 

www.beneo.com 


Gut health 

Naticol ® Gut: supporting optimal gut balance 

Through gut immune modulation, Naticol ® Gut helps nurture a healthier gut microbiota 

Mouna Rahabi, PhD 

Digestive discomfort is a common 

concern affecting the gastrointestinal 

tract and overall well-being. Its origins 

are often multifactorial and not always 

clearly defined, involving a complex 

interplay between lifestyle, diet, environmental 

influences, gut microbiota 

and immune responses¹. 

There is growing evidence that modern 

lifestyle and dietary habits can influence 

digestive balance. Changes in eating 

patterns, particularly the widespread adoption 

of Western-style diets, have been 

associated with alterations in gut microbiota 

composition and intestinal function. 

Diet may affect digestive comfort through 

several pathways, including modifications 

of the gut microbiota, impacts on intestinal barrier function, and 

interactions with the immune system². As a result, nutritional strategies 

are increasingly explored for their potential to support gut 

balance and digestive well-being. While many approaches focus on 

probiotics to promote digestive health, relatively few studies have 

investigated the role of specific nutrients such as collagen peptides 

in this context³. 

Extensive research has documented the anti-inflammatory effects 

of collagen peptides, particularly in joint conditions and skin ageing. 

While their potential for gut health remains underexplored, Weishardt 

is demonstrating the promising effects of Naticol ® Gut. 

Naticol ® Gut, specific bioactive fish collagen peptides 

Weishardt has developed Naticol ® Gut fish collagen peptides, a new 

ingredient obtained through a specific process that generates bioactive 

peptides with gut benefits. 


49

Gut health 

Our scientific team validated the product’s benefits through extensive 

preclinical research. The results demonstrated that Naticol ® Gut can 

significantly reduce the severity of experimental colitis through immunedependent 

mechanisms while promoting a healthier gut microbiota. 

Furthermore, it was shown to help restore the anti-inflammatory profile 

of immune cells from individuals with Inflammatory Bowel Disease 

(IBD), highlighting its promising potential for gut support. 

Naticol ® Gut delivers anti-inflammatory activity 

within the gut 

The gut immune system plays a central role in regulating the inflammatory 

status of the gastrointestinal tract. Among immune cells, 

macrophages are a key population involved in maintaining intestinal 

balance. Under normal physiological conditions, intestinal 

macrophages remain tolerant to the gut microbiota, preventing inappropriate 

immune responses. In contrast, in inflammatory conditions, 

a large infiltration of macrophages occurs, contributing to the 

disruption of the intestinal barrier through pro-inflammatory and prooxidant 

activities4. 

The experimental colitis model used to evaluate the activity of Naticol ® 

Gut relies on the chemical induction of intestinal inflammation with 

Dextran Sodium Sulfate (DSS), producing symptoms and biological 

alterations comparable to those observed in human colitis 5 . Notably, 

DSS-treated mice receiving Naticol ® Gut showed a reduced level of 

colonic inflammation, as evidenced by decreased immune cell infiltration, 

less crypt loss, and reduced epithelial erosion in histological 

sections of the colon 6 (Figure 1 A). 

Naticol ® Gut beneficially modulates 

the gut microbiota 

The gut microbiota is one of the key factors 

involved in the development of gastrointestinal 

disorders. During intestinal 

inflammation, the balanced interaction 

between the microbiota and the immune 

system becomes disrupted. As a result, 

the microbiota becomes unbalanced while 

the immune system becomes overactivated. 

This microbial imbalance, known as 

dys biosis, is characterized by an increase 

in potentially harmful species and a reduction 

in beneficial, anti-inflammatory microorganisms 

7 . 

Interestingly, administration of Naticol ® Gut 

was shown to reduce the abundance of 

undesirable bacteria such as Enterobacteria 

and Escherichia coli, while promoting 

the growth of beneficial microorganisms 

including Faecalibacterium prausnitzii and 

Lactobacillus murinus. Our study demonstrates 

that this positive modulation of the gut 

microbiota is mediated through the action of 

Naticol ® Gut on the immune system, highlighting 

an important cross-talk between 

these two components 6 (Figure 1 B). 

(A) 

(B) 

Fig. 1: (A) Colonic tissue damage score and (B) microbiota composition. 

*p ≤ 0.05, **p ≤ 0.01 DSS-exposed mice compared to DSS-exposed mice supplemented with Naticol ® Gut 


Gut health 

Naticol ® Gut effectively restores an 

anti-inflammatory immune profile in 

human monocytes 

The efficacy of Naticol ® Gut was directly 

proven on immune blood cells from individuals 

with Inflammatory Bowel Disease 

(IBD). 

The stimulation of these cells with Naticol ® 

Gut led to a clear reduction in pro-inflammatory 

cytokine production, while simultaneously 

increasing the levels of anti-inflammatory 

cytokines 6 (Figure 2). 

These results support that Naticol ® Gut can 

effectively modulate the immune response in 

monocytes from IBD patients by promoting 

an anti-inflammatory profile, underscoring 

its promising potential for human gut health. 

Moreover, Weishardt has advanced the scientific understanding of 

fish collagen peptides by uncovering the mechanisms through which 

Naticol ® Gut delivers its beneficial effects 6 , providing deeper insight 

into its role in gut health. 

References 

1 

Actis, G. C., Pellicano, R., Fagoonee, S. & Ribaldone, D. G. History of Inflammatory Bowel 

Diseases. J. Clin. Med. 8, 1970 (2019). 

2 

Rajendran, N. & Kumar, D. Role of diet in the management of inflammatory bowel disease. 

World J. Gastroenterol. WJG 16, 1442–1448 (2010). 

3 

Rossi, R. E. et al. The role of dietary supplements in inflammatory bowel disease: a systematic 

review. Eur. J. Gastroenterol. Hepatol. 28, 1357–1364 (2016). 

4 

Kühl, A. A., Erben, U., Kredel, L. I. & Siegmund, B. Diversity of Intestinal Macrophages in 

Inflammatory Bowel Diseases. Front. Immunol. 6, (2015). 

5 

Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium 

(DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, 15.25.1-15.25.14 (2014). 

6 

Rahabi, M. et al. Bioactive fish collagen peptides weaken intestinal inflammation by 

orienting colonic macrophages phenotype through mannose receptor activation. Eur. J. Nutr. 

(2022) doi:10.1007/s00394-021-02787-7. 

7 

Ni, J., Wu, G. D., Albenberg, L. & Tomov, V. T. Gut microbiota and IBD: causation or correlation? 

Nat. Rev. Gastroenterol. Hepatol. 14, 573–584 (2017). 

Fig. 2: cytokine production by human blood monocytes from individuals with IBD 

**p ≤ 0.01, ****p ≤ 0.001 human blood monocytes from individuals with IBD compared to the same monocytes stimulated 

with Naticol ® Gut 

Conclusion 

The use of functional ingredients to support 

gut comfort is an emerging approach. In this 

context, Weishardt offers robust preclinical 

evidence, complemented by a translational 

study using immune cells directly obtained 

from human subjects, demonstrating that 

Naticol ® Gut fish collagen peptides effectively 

restores an anti-inflammatory immune 

profile 6 . 


Weishardt International 

Rond-point Georges Jolimaître, 

81300, Graulhet, France 

www.weishardt.com 

www.naticol.com 


51


Probiotics for mothers and children: 

Nurturing health from day one 

Laura Castres 

Human health is shaped by microbial conversations that 

begin before birth and continue throughout childhood. These 

microscopic dialogues shape immunity, metabolism, brain 

development, and lifelong health. For mothers and their children, 

the first thousand days, from conception through age 

two, represent a critical window where microbial foundations 

are built.(1) 

When the gut microbiome thrives, it supports robust health. When 

disrupted - by antibiotics, stress, or illness - consequences can echo 

across generations. This is where probiotics enter: live microorganisms 

that, when administered appropriately, confer health benefits. 

(2) Decades of research have established their efficacy for specific 

maternal and pediatric applications. 

Supporting mothers through pregnancy 


Gestational diabetes affects approximately 14 % of pregnancies 

worldwide, carrying risks for mother and baby.(3) Some largescale 

analyses show that probiotic supplementation can reduce this 

risk by up to 30 %, with strongest benefits 

observed in younger women with a healthy 

body weight.(4) Early intervention (in the 

first trimester) appears the most effective. 

In a randomized clinical trial (RCT), probiotic 

supplementation combined with dietary 

recommendations as soon as the first 

trimester reduced the prevalence of gestational 

diabetes from 36 % to 13 %.(5) Probiotics 

work at multiple levels, they enhance 

insulin sensitivity, reduce inflammation, and 

optimize metabolic adaptation. Multiple 

studies also demonstrate that probiotics 

help to manage gestational weight gain. (6) 

Vaginal and breast health 

Bacterial vaginosis is a manifestation of 

vaginal dysbiosis that can affect up to 30 % 

of pregnant woman and is associated with 

higher risk of preterm birth. Oral probiotic 

supplementation with specific Lactobacillus 



strains can restore vaginal balance by inhibiting 

the growth of harmful bacteria, via the 

production of lactic acid and the secretion 

of antimicrobial compounds.(7) 

Lactational mastitis affects 10-30 % of 

breastfeeding mothers, frequently leading to 

premature weaning. Probiotic supplementation 

show efficacy for both the prevention 

and management of mastitis, with beneficial 

bacteria being transferred to infants during 

breastfeeding (vertical transmission).(8) 

Mental wellbeing 

Perinatal mental disorders affect one in 

five women. The gut-brain axis, mediated 

by neural, immune and hormonal signals, 

offers new avenues for supporting maternal 

mental wellbeing. Clinical trials demonstrate 

that probiotics can reduce depressive 

and anxiety symptoms by producing moodregulating 

compounds, modulating stress 

hormones, and reducing inflammation.(9) 

Optimizing infant health 

Relieving colic 

Infantile colic affects roughly 20 % of babies. 

Evidence increasingly points to gut microbial 

imbalance. Recent analyses found that 

probiotic supplementation can reduce daily 

crying time by nearly an hour – particularly 

pronounced in breastfed infants.(10,11) 

Benefits are observed within one week with 

reduced gut inflammation, improved gut 

motility, and restoration of a balanced intestinal 

microbiota.(12) 

Preventing allergies 

Multiple studies suggest a role of probiotics 

in preventing or relieving atopic diseases, 

including eczema and allergic rhinitis in 

infants. Oral administration in pregnant 

women, breastfeeding mothers or infants 

suggest greatest benefits of probiotic 

supplementation when given during both 

pregnancy and early infancy. Beneficial 

effects are also more pronounced in highrisk 

(with family history) infants. Mechanisms 

include an improved immune tolerance 

(prevention of overreactions), restoration 

of microbial balance, and barrier reinforcement. 

Reducing respiratory infections 

Young children experienced an average of six to eight respiratory 

infections annually. Systematic reviews demonstrate that probiotic 

supplementation significantly reduces illness duration, frequency, and 

school absenteeism - most observed in daycare-attending children. 

(17,18) Some studies also report reductions in antibiotic prescription 

rates associated with the preventive probiotic use, addressing antimicrobial 

resistance. 

Protecting premature infants 

Necrotizing enterocolitis - a life-threatening intestinal disease – carries 

20-30 % mortality in premature infants. Large scale analyses demonstrate 

that probiotics significantly reduce the incidence of necrotizing 

enterocolitis, sepsis, and mortality.(19,20) Combinations of Lactobacillus 

and Bifidobacterium species show the best benefits to prevent 

NEC likely through the restoration of gut microbiota and modulation 

of the immune system. Many leading neonatal units worldwide now 

implement probiotic protocols with strict quality assurance.(21) 

Restoring missing microbes 

Bifidobacterium longum subsp. infantis – a keystone infant gut 

species – is disappearing from infant gut microbiota in industrialized 

nations. Recent studies show that supplementing breastfed infants 

between two and four months of age successfully restores this colonization, 

with bacteria persisting even after supplementation ends (22). 

This enrichment is critical because B. infantis can metabolize human 

milk oligosaccharides (HMOs), thereby establishing a co-evolved 

symbiosis which participates in immune maturation and metabolic 

programming.(23) 

How probiotics work 

Probiotics influence health through multiple mechanisms: 

• competing with pathogens for both nutrients and colonization sites 

and producing antimicrobial compounds; 

• strengthening intestinal barriers by upregulating tight junction 

proteins and stimulating mucus secretion;(24) 

• modulating immune function by promoting cells that prevent 

excessive inflammation while enhancing defences against 

infections;(25) 


53


• and generating bioactive compounds including short-chain fatty 

acids, vitamins, and neuroactive substances that extend benefits 

beyond the gut.(26) 

The Exden difference 

At Exden, we are biotics specialists – this is our core expertise. Our 

formulations are built on scientifically validated strains with demonstrated 

human efficacy, developed and manufactured at our French 

site entirely dedicated to biotic supplements (ISO 22000, HACCP 

certified). As a full-service private label partner, we offer complete 

solutions – from strain selection and formulation development to 

production, with scientific support and regulatory compliance - for 

brands seeking to enter maternal and child probiotic markets with 

rigour and confidence. 

While probiotic stability is a critical challenge across the industry, 

our proprietary Probiopack ® technology addresses it systematically: 

combining clinically relevant strains within an optimised matrix, 

paired with adapted dosage forms - capsules, powders, or oils - and 

appropriate packaging to maximise viability from production through 

to the end of shelf life. 

Looking forward 

The evidence supporting probiotics in maternal and child health has 

reached substantial maturity. From reducing the risk of gestational 

diabetes to soothing colicky babies, from preventing childhood allergies 

to protecting premature infants, probiotics offer scientifically validated 

interventions for common conditions significantly impacting 

family wellbeing. 

The science continues to advance rapidly, refining our understanding 

of optimal strain selection, timing, and dosing. Integration of microbiome 

science with clinical practice promises to unlock even greater 

potential for supporting health during critical developmental windows. 

At Exden, we develop evidence-based solutions through scientific 

monitoring, uncompromising quality, and transparent communication. 

We aim to realize the full potential of probiotics to promote lifelong 

health from the very beginning. 


Laura Castres, Marketing Manager at 

Exden 

1, rue Alessandro Volta 

44470 Carquefou, France 

contact@exden.fr 

www.exden.fr 

References 

(1) Robertson RC et al. The Human Microbiome and Child Growth — First 1000 Days and 

Beyond. Trends Microbiol. 2019;27(2):131-147. 

(2) Hill C et al. The International Scientific Association for Probiotics and Prebiotics 

consensus statement on the scope and appropriate use of the term probiotic. Nat Rev 

Gastroenterol Hepatol. 2014;11(8):506-514. 

(3) Wang H et al. IDF Diabetes Atlas: estimation of global and regional gestational diabetes 

mellitus prevalence for 2021. Diabetes Res Clin Pract. 2022;183:109050. 

(4) Li X et al. Probiotics for the prevention of gestational diabetes mellitus: a meta-analysis 

of randomized controlled trials. Biomol Biomed. 2024;24(5):1092-1104. 

(5) Luoto R et al. Impact of maternal probiotic-supplemented dietary counselling on pregnancy 

outcome and prenatal and postnatal growth: a double-blind, placebo-controlled 

study. Br J Nutr. 2010;103(12):1792-1799. 

(6) Jia X. Meta-analysis of probiotic metabolites in the prevention of gestational weight 

gain and postpartum weight retention. Front Cell Infect Microbiol. 2025;15 :1627206 

(7) Afifirad R et al. Effects of pro/prebiotics alone over pro/prebiotics combined with 

conventional antibiotic therapy to treat bacterial vaginosis: a systematic review. Int J Clin 

Pract. 2022;2022:4774783. 

(8) Fernández L et al. Prevention of infectious mastitis by oral administration of Lactobacillus 

salivarius PS2 during late pregnancy. Clin Infect Dis. 2016;62(5):568-573. 

(9) Slykerman RF et al. Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum 

symptoms of depression and anxiety: a randomised double-blind placebocontrolled 

trial. EBioMedicine. 2017;24:159-165. 

(10) Vaz SR et al. Probiotics for infantile colic: is there evidence beyond doubt? A metaanalysis 

and systematic review. Acta Paediatr. 2024;113(2):170-182. 

(11) Ong TG et al. Probiotics to prevent infantile colic. Cochrane Database Syst Rev. 

2019;3:CD012473. 

(12) Skonieczna-Żydecka K et al. The effect of probiotics on symptoms, gut microbiota 

and inflammatory markers in infantile colic: a systematic review, meta-analysis and metaregression 

of randomized controlled trials. J Clin Med. 2020;9(4):999. 

(13) Wang F et al. The effect of probiotics in the prevention of atopic dermatitis in children: 

a systematic review and meta-analysis. Transl Pediatr. 2023;12(4):731-748. 

(14) Zuccotti G et al. Probiotics for prevention of atopic diseases in infants: systematic 

review and meta-analysis. Allergy. 2015;70(11):1356-1371. 

(15) Luo X et al. Effects of probiotics on the prevention and treatment of children with allergic 

rhinitis: a meta-analysis of randomized controlled trials. Front Pediatr. 2024;12:1352879. 

(16) Jiang L et al. Probiotics supplementation during pregnancy or infancy on multiple 

food allergies and gut microbiota: a systematic review and meta-analysis. Nutr Rev. 

2025;83(2):e25-e41. 

(17) Zhao Y et al. Probiotics for preventing acute upper respiratory tract infections. 

Cochrane Database Syst Rev. 2015;(2):CD006895. 

(18) Wang Y et al. Probiotics for prevention and treatment of respiratory tract infections in 

children: a systematic review and meta-analysis of randomized controlled trials. Medicine 

(Baltimore). 2016;95(31):e4509. 

(19) Sharif S et al. Probiotics to prevent necrotising enterocolitis in very preterm or very low 

birth weight infants. Cochrane Database Syst Rev. 2023;7(7):CD005496. 

(20) Han J et al. The effectiveness of probiotics in preventing necrotizing enterocolitis and 

related mortality: results from an umbrella meta-analysis on meta-analyses of randomized 

controlled trials. BMC Gastroenterol. 2025;25(1):245. 

(21) Poindexter B; AAP Committee on Fetus and Newborn. Use of probiotics in preterm 

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Where 

Ingredient Science 

Meets Applied 

Health Innovation 

IFT FIRST connects global food science and ingredient expertise 

to support evidence based innovation across functional ingredients, 

fortified nutrition, and product development. 

Join Us 

ift.org/ift-first-event 

July 12-15, 2026

Vitafoods Europe – Preview 

Vitafoods Europe unveils programme 

to help industry navigate 

the sector’s most disruptive trends 

The programme features over 100 expert speakers from across the nutraceutical sector, including Professor 

Tim Spector OBE as keynote speaker at the Future of Nutrition Lunch and Learn. 

Vitafoods Europe (5–7 May 2026), the leading global platform 

for the nutraceutical, functional food and beverage, and 

dietary supplement industries, has unveiled the agenda for 

its largest and most forward-looking edition yet. The 2026 

programme is designed to help brands respond to some of 

the most disruptive forces shaping the nutraceuticals landscape, 

with full day sessions dedicated to the explosive 

impact of GLP-1 medications on nutrition strategies and the 

rapidly rising beauty-from-within market. 

These spotlight sessions will take place on day three of the show, 

running alongside an extensive programme of more than 37 hours 

of content across multiple stages, including the Vitafoods Insights 

Theatre and the Vitafoods Europe Conference. With over 100 expert 

speakers from across the nutraceutical sector, the programme offers 

unmatched insight into emerging trends, product innovation, and the 

future of nutrition. Speaker highlights include Professor Tim Spector 

OBE, Scientific Co-Founder at ZOE and Professor of Genetic Epidemiology 

at King's College London, alongside leading specialists in 

trends and innovation, such as Mintel, FMCG Gurus, Innova Market 

Insights and more. 

The GLP-1 era: turning disruption into 

opportunity 

With more than 150 new GLP-1 drug candidates 

currently in development,[1] products 

making GLP‐1‐related claims have grown 

at an estimated 124 % CAGR over the past 

five years,[2] meaning the weight management 

sector is set for a transformative shift. 

In response, demand is growing for targeted 

nutritional solutions that support users 

throughout the GLP-1 journey, including for 

muscle maintenance, metabolic health and 

overall wellbeing. 

To help brands navigate this evolving landscape, 

Vitafoods Europe 2026 will host a 

dedicated spotlight on weight management 

on 7 May. Sessions will include discussions 

on the need to shift from focusing on 

calorie restriction to holistic, evidence-based 



approaches; the potential of plant-based 

proteins for metabolic support; and emerging 

supplement-based alternatives to GLP-1 

medications – offering insights into how the 

nutraceutical sector can deliver effective 

tailored results for consumers. Key sessions 

will include Sophia Cornelius, specialised 

Nutrition Analyst at Mintel, on “The future 

of weight management: Nutrition innovation 

in a GLP-1 era” and a panel discussion 

on complementary supplements for GLP-1s, 

featuring Lauren Struszczak, Senior Scientist 

at the British Nutrition Foundation. 

market, with Innova Market Insights highlighting 

its top ten trends for 2026 (May 

5) to open the stage. Another key highlight 

will be the Startup Challenge live pitches 

and awards (May 5), which will showcase 

breakthrough ideas from rising innovators. 

Meanwhile the Vitafoods Europe Conference 

serves as the central hub for cuttingedge 

science, with a carefully curated 

programme designed to inspire and equip 

professionals in R&D, product development, 

innovation, and strategy roles. These content 

features will join the Nutraceutical Showcase 

Theatre, which was introduced last year to 

feature voices from across the entire nutraceutical 

supply chain, from contract manufacturers 

to finished products and beyond. 

Networking and knowledge 

Also returning in 2026 are networking 

sessions created to facilitate industry 

Beauty-from-within: the next nutrition 

boom 

The rapidly accelerating beauty-from-within 

movement is positioning nutricosmetics as 

one of the most exciting frontiers in the global 

nutrition industry, with the market projected 

to grow from around $8.3 billion in 2026 to 

nearly $16 billion by 2034.[3] As consumers 

increasingly link appearance with overall wellbeing, 

innovation is expanding beyond traditional 

supplements into functional foods, 

beauty drinks and longevity-focused nutrition. 

Vitafoods Europe’s dedicated nutricosmetics 

spotlight will bring experts together to 

explore the science and innovation shaping 

the future of ingestible beauty. Sessions 

will explore the convergence of beauty, 

nutrition and pharma innovation, examining 

evidence for emerging ingredients – 

including peptides, antioxidants and marine 

compounds – and highlight the preventative 

“beauty-from-within” strategies resonating 

with younger consumers. Attendees will take 

a deep dive into the rapidly expanding nutricosmetics 

market and its global impact, with 

a highlight session from Mike Hughes, Head 

of Research and Insight at FMCG Gurus on 

the market opportunities for nutricosmetics. 

More to learn across the show floor 

Alongside the new spotlight sessions, Vitafoods 

Europe 2026 will see the return of key 

learning platforms. The Vitafoods Insights 

Theatre features presentations covering 

market updates and major consumer 

trends influencing the global nutraceutical


and build meaningful relationships that 

last beyond the show floor, with interactive 

discussions focused on personal and professional 

growth. 

dialogue, including the return of the Future of NutritionLunch & 

Learn. This year’s session will bring together industry experts to 

explore how biohacking and longevity science are shaping the next 

generation of nutraceutical innovation. Newly announced for this 

year, Professor Tim Spector OBE, Scientific Co-Founder at ZOE and 

Professor of Genetic Epidemiology at King's College London, will 

appear as keynote speaker, with further details of his talk to be 

announced soon. 

The Women’s Networking Breakfast also returns for 2026, featuring a 

panel discussion exploring how women’s health is shaping resilience, 

product development and business success across the industry. This 

fan-favourite session aims to create space for women to network 

Speaking on the 2026 agenda, Gareth 

Baguley, Brand Director, Vitafoods Europe, 

Informa Markets, says: “We are in what 

is perhaps the most dynamic period of 

nutraceutical innovation in recent history. 

Advances in science and technology are 

rapidly reshaping what is possible and 

raising expectations around how nutrition 

can support health. As a result, we are seeing 

a fundamental shift towards solutions that 

support health in more personalised, preventative 

and holistic ways. The Vitafoods Europe 

2026 programme is designed to bring these 

shifts into sharp focus, enabling the global 

nutrition community to explore the ideas, 

research and collaborations that will define 

the next chapter of nutraceuticals.” 

Registration for Vitafoods Europe 2026 is 

now open. 

Don’t miss out by securing your pass today: 

www.vitafoods.eu.com/en/home.html 

To explore the full agenda, please visit 

www.vitafoods.eu.com/en/whats-on/agenda/full-programme.html. 

Impressum 

ISSN 2364-8104 

Wellness Foods & Supplements | No. 1/2026 

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Wellness Foods + Supplements 1/2026

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