Immunogenicity and aggregation of therapeutic proteins - American ...

Immunogenicity and aggregation of
therapeutic proteins
In cooperation with
Keynote Speakers
John Carpenter
University of Colorado
Mary Cromwell
Genentech Inc.
Huub Schellekens
Utrecht University
Poster session – Exhibition
4 th to 5 th October 2011
Berlin, Germany
Course No. 6385
International Association for Pharmaceutical Technology

Immunogenicity and aggregat
Day 1: Immunogenicity of Protein Formulation
Tuesday, 4 th October 2011
10.00 to 17.30 h
Welcome
Gerrit Borchard
Université de Genève
Geneva, Switzerland
Introduction to the course programme
Gerrit Borchard
Université de Genève
Geneva, Switzerland
Innate immunity in protein drug
immunogenicity
N. N.
Utrecht University
Utrecht, The Netherlands
Protein drug formulation & immunogenicity
John Carpenter
University of Colorado
Denver, United States
Lunch, poster & exhibition
The role of protein charge and proximity
energies in aggregation and viscosity
Prof. Thomas M. Laue
University of New Hampshire
Durham, United States
Immunogenicity in preclinical testing
Anja Langenkamp
Roche AG
Basel, Switzerland
Coffee break, poster & exhibition
Regulatory requirements for immunogenicity
testing
Brigitte Brake
Bundesinst. f. Arzneimittel u. Medizinprodukte
(BfArM)
Bonn, Germany
Panel discussion, Q & A
City tour and networking dinner
Day 2: Protein Aggregation
Wednesday, 5 th October 2011
09.00 to 16.00 h
Welcome
Karoline Bechtold-Peters
Roche AG
Basel, Switzerland
Protein aggregation
Jamie Moore
Genentech Inc.
South San Francisco, United States
Detection and characterization of particles in
drug products
Hanns-Christian Mahler
Roche AG, Basel, Switzerland
Coffee break, poster & exhibition
Freeze-drying and aggregates
Andrea Wiggenhorn-Hawe
Coriolis Pharma Services GmbH
Martinsried, Germany
Orthogonal methods for aggregate analysis
Kay Vogel
Boehringer Ingelheim Pharma GmbH und Co. KG
Biberach/Riss, Germany
Lunch, poster & exhibition
Influence of packaging on protein aggregation
Linda Narhi
Amgen Inc.
Thousand Oaks, United States
Stabilization of highly concentrated protein solutions
Tudor Arvinte
Therapeomic Inc.
Basel, Switzerland
Panel discussion, Q & A and closing
Programme is subject to change

on of therapeutic proteins
In cooperation with
Therapeutic protein candidates are increasingly entering the pipelines of pharmaceutical companies
and the marketplace in spite of production, formulation and safety challenges encountered. This 2day
conference held under the auspices of APV (www.apv-mainz.de) and AAPS (www.aaps.org) will
focus on issues in immunogenicity and protein aggregation by gathering opinion leaders from academia,
industry and regulatory authorities for an update on the state-of-the-art. The conference will
also offer to students the presentation of their latest results in poster format, and the display of
advanced analytical technology to suppliers in an industrial exhibition.
Karoline Bechtold-Peters, Roche AG, Basel, Switzerland
Gerrit Borchard, University of Geneva, Switzerland
Dr. Michael Wiggenhorn, Coriolis Pharma Services GmbH, Martinsried, Germany
AAPS
The American Association of Pharmaceutical Scientists
is a professional, scientific society of more than
12,000 members employed in academia, industry,
government and other research institutes worldwide.
Founded in 1986, AAPS provides a dynamic international
forum for the exchange of knowledge among
scientists to enhance their contributions to public
health. AAPS offers timely scientific programs, ongoing
education, information resources, opportunities
for networking, and professional development.
APV – Making Science Work
APV is the pharmaceutical non-for-profit
association in German-speaking countries and in
Europe for everyone involved in the field of pharmaceuticals.
We support pharmaceutical sciences and
technology as well as all related disciplines, circulate
knowledge and knowhow from these fields and
represent the scientific interests in these areas in academia,
the industry and regulatory authorities. Our
society promotes research and development in academia
and in the industry and a platform for sharing
and spreading scientific information related to
pharmaceuticals. We enhance professional skills by
conducting high-quality training seminars.
As experts, we contribute to opinion making
in the relevant authorities, associations and in the
public press. We publish our own scientific journal
(EJPB – European Journal of Pharmaceutics and
Biopharmaceutics).

Abstract Submission:
You are kindly invited to submit abstracts for poster presentations
during the conference.
Please send all abstracts (2 pages) to mb@apv-mainz.de
Deadlines:
Call for Abstracts – Open 15 th April 2011
Abstract Submission – Deadline 1 st August 2011
Notification of Acceptance – 1 st September 2011
Social Programme:
A city tour and networking dinner will give the participants the
opportunity to get together.
Exhibition and sponsoring:
For exhibition and sponsoring opportunities please contact the APV
headquarters
Phone +49 6131 9769-85
e-mail it@apv-mainz.de
Register by Tuesday 31 st May 2011 to take advantage of the early bird fee
Course No. 6385
Immunogenicity and aggregation of therapeutic proteins
Berlin, Germany, 4 th to 5 th October 2011
Title, First Name, Name
Company/institution name
Company/institution address
Phone Fax
e-mail Order no.
Position in Company/institution Department
APV member Non-member
Date Signature
Date
Course No. 6385
from 04 th Oct. 2011 10:00
to 05 th Oct. 2011 16:00
Location
Holiday Inn Berlin City-West
Rohrdamm 80
13629 Berlin, Germany
Phone: +49 30 38389-0
Fax: +49 30 38389-900
Early bird Full fee
Member of APV 1260 EUR 1360 EUR
Non-Member of APV 1390 EUR 1490 EUR
Member of APV (Academic, Governmental) 630 EUR 680 EUR
Non-Member of APV (Academic, Governmental) 695 EUR 745 EUR
Member of APV (Students) 120 EUR 150 EUR
Registration
All correspondence regarding the
conference should be addressed
to:
APV-Geschäftsstelle
Kurfürstenstraße 59
55118 Mainz/Germany
Phone: +49 6131 9769-0
Fax: +49 6131 9769-69
e-mail: apv@apv-mainz.de
You will receive a confirma-tion
of your registration with the
invoice.