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Effects of Thai Traditional Massage on Autistic Children's Behavior

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THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE<br />

Volume 15, Number 12, 2009, pp. 1355–1361<br />

ª Mary Ann Liebert, Inc.<br />

DOI: 10.1089=acm.2009.0258<br />

Abstract<br />

<str<strong>on</strong>g>Effects</str<strong>on</strong>g> <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>Thai</str<strong>on</strong>g> <str<strong>on</strong>g>Traditi<strong>on</strong>al</str<strong>on</strong>g> <str<strong>on</strong>g>Massage</str<strong>on</strong>g> <strong>on</strong> <strong>Autistic</strong><br />

Children’s <strong>Behavior</strong><br />

Krisna Piravej, M.D., 1 Preeda Tangtr<strong>on</strong>gchitr, B.Sc.(Pharm), M.Sc., 2 Parichawan Chandarasiri, M.D., 3<br />

Luksamee Paoth<strong>on</strong>g, M.D., 1 and Saengaro<strong>on</strong> Sukpras<strong>on</strong>g, B.Sc. 4<br />

Objectives: The objective <str<strong>on</strong>g>of</str<strong>on</strong>g> this study was to access whether there were any therapeutic effects <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>Thai</str<strong>on</strong>g> <str<strong>on</strong>g>Traditi<strong>on</strong>al</str<strong>on</strong>g><br />

<str<strong>on</strong>g>Massage</str<strong>on</strong>g> (TTM) <strong>on</strong> major behavioral and emoti<strong>on</strong>al disturbances in <str<strong>on</strong>g>Thai</str<strong>on</strong>g> autistic children.<br />

Design: This was a randomized c<strong>on</strong>trolled trial study.<br />

Settings=locati<strong>on</strong>: The study was c<strong>on</strong>ducted at the Rehabilitati<strong>on</strong> Centre <str<strong>on</strong>g>of</str<strong>on</strong>g> the <str<strong>on</strong>g>Thai</str<strong>on</strong>g> Red Cross Society.<br />

Subjects: A total <str<strong>on</strong>g>of</str<strong>on</strong>g> 60 autistic children between the ages <str<strong>on</strong>g>of</str<strong>on</strong>g> 3 and 10 completed this study.<br />

Interventi<strong>on</strong>s: Standard sensory integrati<strong>on</strong> therapy (SI) was compared to the SI with TTM treatments.<br />

Outcome measures: Parents and teachers assessed major behavior disturbances using the C<strong>on</strong>ners’ Rating Scales<br />

at 0 and 8 weeks. Sleep Diary (SD), recorded by the parents, assessed the patient’s sleeping patterns every week.<br />

Results: Sixty (60) autistic children, mean age 4.67 1.82, were recruited. No statistical differences were seen in<br />

the demographic and baseline data am<strong>on</strong>g both groups. From both the C<strong>on</strong>ners’ Teacher Questi<strong>on</strong>naire and SD,<br />

statistical improvement was detected for c<strong>on</strong>duct problem, hyperactivity, inattenti<strong>on</strong>-passivity, hyperactivity<br />

index, and sleeping behavior. However, results from the C<strong>on</strong>ners’ Parent Questi<strong>on</strong>naire revealed an improvement<br />

<strong>on</strong>ly for anxiety ( p ¼ 0.04) in the massage group, whereas when both groups were compared, a significant<br />

improvement in c<strong>on</strong>duct problem ( p ¼ 0.03) and anxiety ( p ¼ 0.01) was found. Results indicated that TTM may<br />

have a positive effect in improving stereotypical behaviors in autistic children.<br />

C<strong>on</strong>clusi<strong>on</strong>s: Over a period <str<strong>on</strong>g>of</str<strong>on</strong>g> 8 weeks, our findings suggested that TTM could be used as a complementary<br />

therapy for autistic children in <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land.<br />

Introducti<strong>on</strong><br />

In recent years, autism spectrum disorders have received<br />

increased attenti<strong>on</strong> in youngsters. The number <str<strong>on</strong>g>of</str<strong>on</strong>g> individuals<br />

diagnosed with autism has dramatically increased in the<br />

past few years. Similarly, in <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land, autism has also become<br />

a more comm<strong>on</strong>ly diagnosed childhood brain disorder. It was<br />

found that 4.4 <str<strong>on</strong>g>of</str<strong>on</strong>g> 1000 <str<strong>on</strong>g>Thai</str<strong>on</strong>g> children were pr<strong>on</strong>e to be autistic,<br />

and the prevalence rate has been 9.9 children per 10,000<br />

populati<strong>on</strong>s. 1 These patients typically dem<strong>on</strong>strated problems<br />

in behavior and were less effective communicators.<br />

Interestingly, no single cause has been identified for the<br />

development <str<strong>on</strong>g>of</str<strong>on</strong>g> autism. 2–7 Presently, since neuropsychological<br />

etiology is essentially unknown, 8,9 it is difficult to treat<br />

autism from a pharmaceutical standpoint. 2,3,10 This situati<strong>on</strong><br />

has created a demand for n<strong>on</strong>pharmaceutically based treatments<br />

and has led to the development <str<strong>on</strong>g>of</str<strong>on</strong>g> treatment methodologies<br />

in a wide variety <str<strong>on</strong>g>of</str<strong>on</strong>g> fields.<br />

For example, sensory integrati<strong>on</strong> therapy (SI) uses the<br />

child’s intrinsic motivati<strong>on</strong> to help change the child’s adaptive<br />

resp<strong>on</strong>se by utilizing a wide variety <str<strong>on</strong>g>of</str<strong>on</strong>g> play media, activities,<br />

and=or equipment to stimulate sensory integrati<strong>on</strong>. 11 This<br />

process occurs at the neur<strong>on</strong>al cellular level where many parts<br />

<str<strong>on</strong>g>of</str<strong>on</strong>g> the nervous system work together to allow the pers<strong>on</strong> to<br />

interact with the envir<strong>on</strong>ment effectively and experience appropriate<br />

satisfacti<strong>on</strong>. 12 At each sessi<strong>on</strong>, the therapist will<br />

select a sensory agent that has either a facilitatory or an inhibitory<br />

effect <strong>on</strong> the child’s nervous system that will target<br />

certain adaptive resp<strong>on</strong>ses such as reflex integrati<strong>on</strong>, adequate<br />

postural adjustments, movement successes, increased alertness<br />

and awareness <str<strong>on</strong>g>of</str<strong>on</strong>g> input, self-regulati<strong>on</strong> without maladaptive<br />

emoti<strong>on</strong>al reacti<strong>on</strong>s, and abilities to start and<br />

participate in the task through to completi<strong>on</strong>. 13 This technique<br />

has been shown to help decrease tactile and other sensitivities<br />

to stimuli known to interfere with the children’s ability to<br />

play, learn, and interact. 14,15<br />

Departments <str<strong>on</strong>g>of</str<strong>on</strong>g> 1 Rehabilitati<strong>on</strong> Medicine and 3 Psychiatry, Faculty <str<strong>on</strong>g>of</str<strong>on</strong>g> Medicine, Chulal<strong>on</strong>gkorn University, Bangkok, <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land.<br />

2 WATPO <str<strong>on</strong>g>Thai</str<strong>on</strong>g> <str<strong>on</strong>g>Traditi<strong>on</strong>al</str<strong>on</strong>g> Medicine and <str<strong>on</strong>g>Massage</str<strong>on</strong>g> School, Bangkok, <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land.<br />

4 Rehabilitati<strong>on</strong> Centre, <str<strong>on</strong>g>Thai</str<strong>on</strong>g> Red Cross Society, Samuthprakarn, <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land.<br />

1355


1356 PIRAVEJ ET AL.<br />

Other new approaches have emerged to improve socializati<strong>on</strong><br />

and learning abilities <str<strong>on</strong>g>of</str<strong>on</strong>g> these patients. 2,9,16,17 These<br />

interventi<strong>on</strong>s are starting to involve the parents <str<strong>on</strong>g>of</str<strong>on</strong>g> the patients<br />

in the therapeutic sessi<strong>on</strong>s. In additi<strong>on</strong>, some <str<strong>on</strong>g>of</str<strong>on</strong>g> the skills used<br />

by the occupati<strong>on</strong>al therapists are being transferred to the<br />

parents such as massages or touch therapies so they can c<strong>on</strong>tinue<br />

administering these techniques at home at their own<br />

c<strong>on</strong>venience. 18<br />

It has been reported that tactile stimulati<strong>on</strong> in the form <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

massage could reduce stereotypical behavior and touch aversi<strong>on</strong>s<br />

as well as improve sleep disturbance, classroom c<strong>on</strong>centrati<strong>on</strong>,<br />

and social interacti<strong>on</strong>s. 19 Another study showed<br />

massages delivered by the parents significantly improved<br />

sleep and enhanced behavior c<strong>on</strong>trol in preschool autistic<br />

children. 20 Likewise, Cullen-Powell et al. (2005) dem<strong>on</strong>strated<br />

that massage therapy was able to calm and relax autistic<br />

children enough to pay attenti<strong>on</strong> to classroom activities. 18<br />

Though these initial evidences are encouraging, the number <str<strong>on</strong>g>of</str<strong>on</strong>g><br />

studies is still scarce and warrant further studies in this area.<br />

Of note, <str<strong>on</strong>g>Thai</str<strong>on</strong>g> <str<strong>on</strong>g>Traditi<strong>on</strong>al</str<strong>on</strong>g> <str<strong>on</strong>g>Massage</str<strong>on</strong>g> (TTM) has never been<br />

studied in autistic patients even though <str<strong>on</strong>g>Thai</str<strong>on</strong>g> massages have<br />

been used frequently as an alternative therapy dating back<br />

more than 2500 years ago. This technique has been traditi<strong>on</strong>ally<br />

attributed to Shivaga Komarapaj, the Lord <str<strong>on</strong>g>of</str<strong>on</strong>g> Buddha’s<br />

doctor and the Father <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>Thai</str<strong>on</strong>g> Medicine. The <str<strong>on</strong>g>Thai</str<strong>on</strong>g>s have<br />

combined Indian yoga with Chinese acupressure, resulting in<br />

a unique <str<strong>on</strong>g>Thai</str<strong>on</strong>g> style massage. It is noteworthy that TTM does<br />

not c<strong>on</strong>centrate <strong>on</strong> the muscles but focuses <strong>on</strong> the entire<br />

physical body by manipulating invisible channels and energy<br />

bodies known as auric body. By applying pressure to vital<br />

points al<strong>on</strong>g these channels, the therapist’s internal energy is<br />

used to boost and stimulate the flow <str<strong>on</strong>g>of</str<strong>on</strong>g> the patient’s internal<br />

energy, and direct it toward the patient’s ailing organs and<br />

glands. Hence, TTM is c<strong>on</strong>sidered to be both spiritual and<br />

therapeutic. For this reas<strong>on</strong>, we wanted to investigate whether<br />

this alternative therapy, TTM, can be used to improve<br />

behavioral and emoti<strong>on</strong>al disturbances in <str<strong>on</strong>g>Thai</str<strong>on</strong>g> autistic children<br />

in combinati<strong>on</strong> with SI.<br />

Materials and Methods<br />

Participant selecti<strong>on</strong><br />

The study protocol was approved by The Instituti<strong>on</strong>al<br />

Review Board <str<strong>on</strong>g>of</str<strong>on</strong>g> the Faculty <str<strong>on</strong>g>of</str<strong>on</strong>g> Medicine, Chulal<strong>on</strong>gkorn<br />

University, Bangkok, <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land. This was a randomized,<br />

c<strong>on</strong>trolled clinical trial comparing the effects <str<strong>on</strong>g>of</str<strong>on</strong>g> TTM, a behavioral<br />

interventi<strong>on</strong>, with SI in <str<strong>on</strong>g>Thai</str<strong>on</strong>g> autistic children between<br />

the ages <str<strong>on</strong>g>of</str<strong>on</strong>g> 3 and 10 who were recruited from the Rehabilitati<strong>on</strong><br />

Centre <str<strong>on</strong>g>of</str<strong>on</strong>g> the <str<strong>on</strong>g>Thai</str<strong>on</strong>g> Red Cross Society. This Centre<br />

received referrals from several doctors from different hospitals<br />

located throughout <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land and hence was the perfect<br />

venue for us to recruit our participants.<br />

A total <str<strong>on</strong>g>of</str<strong>on</strong>g> 60 autistic children were enrolled in the study and<br />

were randomized into two groups: massage group (n ¼ 30)<br />

and c<strong>on</strong>trol group (n ¼ 30). The c<strong>on</strong>trol group received <strong>on</strong>ly<br />

SI, whereas both SI and TTM were administered to the massage<br />

group. The preferred and ideal treatment for the massage<br />

group should <strong>on</strong>ly be TTM, but since this procedure has<br />

never been studied in autistic children, the local Instituti<strong>on</strong>al<br />

Review Board (IRB) prohibited its use unless it was accompanied<br />

with SI. Each participant was required to have a<br />

definite diagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> autistic disorder made by a psychiatrist<br />

based <strong>on</strong> the Diagnostic and Statistical Manual <str<strong>on</strong>g>of</str<strong>on</strong>g> Mental<br />

Disorders (DSM IV) criteria. In <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land, diagnosing children<br />

with autism based <strong>on</strong> the criteria <str<strong>on</strong>g>of</str<strong>on</strong>g> DSM IV is acceptable. 21<br />

Parental or guardian c<strong>on</strong>sent was obtained from each participant<br />

prior to starting the study. The exclusi<strong>on</strong> criteria<br />

included c<strong>on</strong>traindicati<strong>on</strong>s for TTM such as hematological<br />

disorders, fractures, arthritis, joint dislocati<strong>on</strong>, fevers, cardiovascular,<br />

and pulm<strong>on</strong>ary diseases. Additi<strong>on</strong>al exclusi<strong>on</strong>ary<br />

criteria included the inability to complete 80% <str<strong>on</strong>g>of</str<strong>on</strong>g> the<br />

treatment program or receive a total <str<strong>on</strong>g>of</str<strong>on</strong>g> 13 massage sessi<strong>on</strong>s.<br />

Patients with n<strong>on</strong>cooperative parents or guardians were excluded<br />

to avoid patients lost to follow-up or withdrawals. As<br />

per Good Clinical Trial practices, all patients were informed<br />

that they could withdraw from the study at any time without<br />

losing any current health care benefits from the Centre.<br />

Randomizati<strong>on</strong> and assessment tools<br />

The participants were randomized into the c<strong>on</strong>trol and<br />

massage group via block randomizati<strong>on</strong>. This technique<br />

randomly allocates permutati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> treatments within each<br />

block, maintaining the same size for each group.<br />

The parents were not blinded in accordance with local IRB<br />

guidelines, but the teacher (occupati<strong>on</strong>al therapist) was blinded.<br />

After the patients were randomized, the parents and<br />

teacher were required to fill out the C<strong>on</strong>ners’ Parent Rating<br />

Scales (CPRS) 22 and C<strong>on</strong>ners’ Teacher Rating Scales (CTRS) 22<br />

<strong>on</strong> day 0 and at the end <str<strong>on</strong>g>of</str<strong>on</strong>g> week 8, respectively. Aside from<br />

that, the parents were also required to record their autistic<br />

children’s sleeping behaviors every week in the Sleep Diary<br />

(SD). 23 Assessment using the SD has been shown to be effective<br />

in identifying improvement in sleep disorders in autistic<br />

children. 24 At week 8, both groups were re-evaluated<br />

using the same questi<strong>on</strong>naires from day 0 (Fig. 1).<br />

Clinical interventi<strong>on</strong>s<br />

Both the c<strong>on</strong>trol and massage groups received SI by the<br />

same occupati<strong>on</strong>al therapist, 2 sessi<strong>on</strong>s per week, 1 hour per<br />

sessi<strong>on</strong>, for a durati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> 8 weeks, for a total <str<strong>on</strong>g>of</str<strong>on</strong>g> 16 sessi<strong>on</strong>s.<br />

For each child, the therapist created an appropriate and individualized<br />

therapeutic envir<strong>on</strong>ment. The sessi<strong>on</strong>s utilized<br />

FIG. 1. A randomized c<strong>on</strong>trolled trial C<strong>on</strong>solidated Standards<br />

<str<strong>on</strong>g>of</str<strong>on</strong>g> Reporting Trials (CONSORT) flow diagram.


EFFECTS OF THAI TRADITIONAL MASSAGE 1357<br />

the following key principles <str<strong>on</strong>g>of</str<strong>on</strong>g> SI: (1) Just Right Challenge,<br />

(2) The Adaptive Resp<strong>on</strong>se, (3) Active Engagement, and (4)<br />

Child Directed. 15 For the ‘‘Just Right Challenge,’’ the therapist<br />

created playful activities that were slightly challenging<br />

but easily accomplished by the child. This approach balanced<br />

the abilities <str<strong>on</strong>g>of</str<strong>on</strong>g> the child with the challenges given. As for<br />

‘‘The Adaptive Resp<strong>on</strong>se,’’ the therapist observed the child’s<br />

ability to resp<strong>on</strong>d and adapt to the ‘‘Just Right Challenge’’<br />

activities. In order to reinforce the new behavior, more activities<br />

were given.<br />

Next, for the ‘‘Active Engagement,’’ the therapist c<strong>on</strong>tinued<br />

to challenge the child with artful, creative, playful,<br />

sensory activities to entice the child to incorporate new and<br />

advanced abilities. This enabled the child to ‘‘learn how to<br />

learn’’ by incorporating a variety <str<strong>on</strong>g>of</str<strong>on</strong>g> activities that targeted<br />

specific sensory deficits. These activities incorporated vestibular<br />

integrati<strong>on</strong>, proprioceptive and tactile stimulati<strong>on</strong>. A<br />

planned activity schedule was inserted into the child’s natural<br />

envir<strong>on</strong>ment. Last, for the ‘‘Child Directed,’’ the therapist<br />

followed the child’s lead or suggesti<strong>on</strong>s in creating more<br />

sensory-rich activities to develop a higher cognitive level and<br />

motor functi<strong>on</strong>s. All <str<strong>on</strong>g>of</str<strong>on</strong>g> these activities also included the<br />

child’s caregivers and other relevant pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essi<strong>on</strong>als.<br />

The sec<strong>on</strong>d interventi<strong>on</strong> used was TTM. Only the massage<br />

group received TTM treatments in additi<strong>on</strong> to SI. To avoid<br />

variati<strong>on</strong>s in the massage technique, <strong>on</strong>ly <strong>on</strong>e masseuse was<br />

employed to deliver the massages to all patients in the interventi<strong>on</strong><br />

group. First, pre-massage rapport was d<strong>on</strong>e prior to<br />

the sessi<strong>on</strong> to reduce the patient’s anxiety or fear. Building<br />

rapport with the patient prior to the massage treatment significantly<br />

enhanced the patient’s cooperati<strong>on</strong> and willingness<br />

to be massaged. After that, the child was instructed to lie<br />

down, facing upward while the massage was administered.<br />

The masseuse applied some pressure to the sole <str<strong>on</strong>g>of</str<strong>on</strong>g> the foot for<br />

a few minutes before moving to the foot, leg, thigh, hand, arm,<br />

and fingers. Next, the child changed positi<strong>on</strong>s by lying <strong>on</strong> <strong>on</strong>e<br />

side <str<strong>on</strong>g>of</str<strong>on</strong>g> the body. The foot, leg, thigh, waist, arm, shoulder, and<br />

neck were massaged for a couple minutes in that order. Then<br />

the child was rolled over to face the floor while the foot, calf,<br />

buttock, back, and scapular were massaged. Afterward, the<br />

back was stretched before changing positi<strong>on</strong>s again, this time<br />

lying face up. Once again, the whole entire body was stretched<br />

gently for a few minutes before sitting upward. The back<br />

and shoulders were massaged and stretched. Last, the ears<br />

were massaged gently by pulling them up for a few minutes<br />

before pulling them downward.<br />

During the massage sessi<strong>on</strong>, the parents were encouraged<br />

to be with the patients. To induce a relaxed atmosphere, the<br />

massage room was organized in a certain way and the temperature<br />

was carefully moderated. Meanwhile, the massage<br />

was d<strong>on</strong>e gently with moderate pressure to avoid pain or<br />

injuries. If the patients cried or showed obvious anxiety, the<br />

massage would be terminated immediately. Talc and oil were<br />

used to facilitate the massage. Importantly, the massage<br />

methodology was standardized for the children to avoid<br />

variati<strong>on</strong>s that could affect the results <str<strong>on</strong>g>of</str<strong>on</strong>g> the study (Fig. 2).<br />

Data collecti<strong>on</strong><br />

Data captured for analysis included the following: (1)<br />

General geographic data including age and sex; (2) General<br />

health data such as chr<strong>on</strong>ic diseases, chr<strong>on</strong>ic medicati<strong>on</strong>s,<br />

FIG. 2. <str<strong>on</strong>g>Thai</str<strong>on</strong>g> <str<strong>on</strong>g>Traditi<strong>on</strong>al</str<strong>on</strong>g> <str<strong>on</strong>g>Massage</str<strong>on</strong>g> in autistic child.


1358 PIRAVEJ ET AL.<br />

autistic development pr<str<strong>on</strong>g>of</str<strong>on</strong>g>ile, durati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> autism prior to the<br />

study, and durati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> rehabilitati<strong>on</strong> treatment prior to the<br />

study; (3) <strong>Behavior</strong> assessment data obtained from the C<strong>on</strong>ners’<br />

Rating Scales (CRS) <strong>on</strong> day 0; and (4) SD data <strong>on</strong> sleep<br />

behavior assessed by the sleep assessment form.<br />

Statistical analysis<br />

After the completi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the treatment sessi<strong>on</strong>s, patients in<br />

both the c<strong>on</strong>trol and massage groups were reassessed by using<br />

the CRS and SD. The results were analyzed with standard<br />

statistical methodology by using SPSS versi<strong>on</strong> 12 (SPSS Inc.,<br />

Chicago, IL).<br />

Demographic data were analyzed using mean and standard<br />

deviati<strong>on</strong>. For normal distributi<strong>on</strong>, Student’s t-test was used<br />

whereas for abnormal distributi<strong>on</strong> data, the Mann-Whitney U<br />

test was utilized. For quantitative data, percentage and w 2 test<br />

were used. As for the data from either the c<strong>on</strong>trol or the interventi<strong>on</strong><br />

group, pre- and post-treatment data were analyzed<br />

by using the Wilcox<strong>on</strong> signed-rank test. When both groups<br />

were compared to each other, the pre- and post-treatment<br />

difference scores were calculated by the Mann-Whitney U<br />

test. A p-value


EFFECTS OF THAI TRADITIONAL MASSAGE 1359<br />

Table 3. Comparis<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the C<strong>on</strong>ners’ Parent<br />

Rating Scales, C<strong>on</strong>ners’ Teacher Rating Scales,<br />

and Sleep <strong>Behavior</strong> Before and After Treatment<br />

in C<strong>on</strong>trol Group<br />

Variables Week 0 Week 8 p-value<br />

C<strong>on</strong>ners’ Parent Rating Scales<br />

C<strong>on</strong>duct problem 0.59 (0.34) 0.63 (0.33) 0.27<br />

Learning problem 2.02 (0.56) 1.87 (0.53) 0.32<br />

Psychosomatic 0.43 (0.34) 0.39 (0.25) 0.50<br />

Impulsivity–hyperactivity 1.65 (0.65) 1.69 (0.57) 0.97<br />

Anxiety 0.62 (0.49) 0.73 (0.50) 0.17<br />

Hyperactivity 1.53 (0.48) 1.42 (0.42) 0.27<br />

C<strong>on</strong>ners’ Teacher Rating Scales<br />

C<strong>on</strong>duct problem 1.11 (0.27) 0.71 (0.26) 0.00*<br />

Hyperactivity 2.01 (0.34) 1.49 (0.37) 0.00*<br />

Inattenti<strong>on</strong>–passivity 1.67 (0.27) 1.34 (0.36) 0.00*<br />

Hyperactivity index 1.80 (0.36) 1.28 (0.40) 0.00*<br />

Sleep behavior 13.90 (7.67) 8.20 (6.83) 0.00*<br />

*Statistical significance was defined as a p-value <str<strong>on</strong>g>of</str<strong>on</strong>g>


1360 PIRAVEJ ET AL.<br />

<str<strong>on</strong>g>of</str<strong>on</strong>g> disabilities. 31 As for our study, we did not assess emoti<strong>on</strong>al<br />

b<strong>on</strong>ding and attachment between the parents and their<br />

autistic children because the massage was d<strong>on</strong>e by a pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essi<strong>on</strong>al.<br />

Yet we acknowledged that massage did affect the<br />

behaviors <str<strong>on</strong>g>of</str<strong>on</strong>g> the children to the extent that it could improve<br />

their relati<strong>on</strong>ship with their parents. It would be interesting<br />

to see whether TTM was able to improve the children’s social<br />

skills and communicati<strong>on</strong> with their peers and other family<br />

members.<br />

Similar changes have also been noted for child and adolescent<br />

psychiatric inpatients diagnosed with adjustment and<br />

depressive disorders. They showed significantly less depressi<strong>on</strong><br />

and anxiety through measurements <str<strong>on</strong>g>of</str<strong>on</strong>g> salivary and<br />

urinary cortisol (associated with stress), increase in cooperati<strong>on</strong>,<br />

reducti<strong>on</strong> in night waking, and an increase in time<br />

spent sleeping after receiving massage therapies. 28 Al<strong>on</strong>g the<br />

same lines, another massage study did not rely <strong>on</strong>ly <strong>on</strong><br />

subjective data but more <strong>on</strong> objective data by focusing <strong>on</strong><br />

biological measurements such as electroencephalography<br />

(EEG) wave changes, 32 and vagal activity by measuring<br />

heart rate. 32 From EEG wave changes, Diego and colleagues<br />

were able to show that massage therapies increased alertness<br />

in autistic patients, especially <strong>on</strong> math tasks. The other study<br />

using vagal t<strong>on</strong>es showed an increase <str<strong>on</strong>g>of</str<strong>on</strong>g> this measurement<br />

during massage therapy, which was <str<strong>on</strong>g>of</str<strong>on</strong>g>ten associated with<br />

enhanced attentiveness and a more relaxed state. 33 One <str<strong>on</strong>g>of</str<strong>on</strong>g> the<br />

differences between these studies and ours was that we did<br />

not access for biological measurements, which could help substantiate<br />

results not found significant obtained from the CRS.<br />

Study limitati<strong>on</strong>s<br />

The results from the CRS revealed that both groups were<br />

able to reduce stereotypical behaviors. Since there were no<br />

differences reported by the teacher, we hypothesized that the<br />

CTRS might not be able to provide reliable data as compared<br />

to the data from the CPRS. One possible explanati<strong>on</strong> is that<br />

the teacher may not be familiar with the patients compared<br />

to the parents and their observati<strong>on</strong>s might be limited. Besides,<br />

children were well known to behave differently while<br />

in school from when they were at home with their parents.<br />

As for the results obtained from the CPRS, it was shown<br />

that in the c<strong>on</strong>trol group, there was an improvement in<br />

learning problems, psychosomatic, and hyperactivity variables,<br />

whereas in the massage group, improvement was seen<br />

in five <str<strong>on</strong>g>of</str<strong>on</strong>g> six variables: c<strong>on</strong>duct problems, learning problems,<br />

impulsivity–hyperactivity, anxiety, and hyperactivity. Interestingly,<br />

<strong>on</strong>ly c<strong>on</strong>duct problems and anxiety were found to<br />

be statistically significant in the massage group. The reas<strong>on</strong><br />

for this may be that the study’s sample size may have been<br />

too small to show any significant improvement in the other<br />

variables and=or the CPRS may not be as reliable in obtaining<br />

accurate informati<strong>on</strong> from the parents since they<br />

were not blinded.<br />

Also, we would like to point out that even though the CRS<br />

used in this study was not the most sensitive and reliable<br />

measurement in autistic patients, we c<strong>on</strong>tinued to use the<br />

CRS based <strong>on</strong> another study. 20 The questi<strong>on</strong>naire was<br />

translated into <str<strong>on</strong>g>Thai</str<strong>on</strong>g> and has been widely used in <str<strong>on</strong>g>Thai</str<strong>on</strong>g>land to<br />

assess behavioral problems in children.<br />

Another limitati<strong>on</strong> may be the durati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the study, because<br />

it was difficult to assess any real behavioral changes in<br />

a relatively short time even though three studies, c<strong>on</strong>ducted<br />

in 1 m<strong>on</strong>th, 20 8 weeks, 18 and 4 weeks, 19 were able to show<br />

some changes in the interventi<strong>on</strong> group. Although in our<br />

study we were not able to detect many significant behavioral<br />

changes by 8 weeks, from our findings, TTM may be a useful<br />

treatment opti<strong>on</strong> for autistic children.<br />

Recommendati<strong>on</strong>s<br />

We suggested that for future studies, the durati<strong>on</strong> be extended<br />

with crossover to avoid parent biases. Importantly, a<br />

larger sample size may dem<strong>on</strong>strate more visible significant<br />

improvements in behavioral changes in the massage group.<br />

Furthermore, a 12-m<strong>on</strong>th follow-up interview or questi<strong>on</strong>naire<br />

may reveal the l<strong>on</strong>ger-term outcomes <str<strong>on</strong>g>of</str<strong>on</strong>g> TTM. As for<br />

our study, we were unable to follow up our patients up<strong>on</strong><br />

the completi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the study since most <str<strong>on</strong>g>of</str<strong>on</strong>g> them were referred<br />

to the Centre, which will be a challenge for future studies.<br />

Also, other scales should be used in c<strong>on</strong>juncti<strong>on</strong> with the<br />

CRS to determine whether other variables have improved<br />

over time. Measurements from ABC and ESC will allow us to<br />

expand <strong>on</strong> other variables that cannot be seen from just using<br />

the CRS. In additi<strong>on</strong>, to avoid any biases in the results reported<br />

by the parents, teachers, or other people involved in<br />

the study, videotaping the assessment sessi<strong>on</strong>s and the patient’s<br />

sleeping pattern at home could help investigators in<br />

interpreting the results.<br />

It was important to emphasize that studies based solely <strong>on</strong><br />

the CRS, ABC, and ESC forms were limited by their subjective<br />

nature and possible bias from both the parents and<br />

teachers. Therefore, objective data in the form <str<strong>on</strong>g>of</str<strong>on</strong>g> biological<br />

measurements studies are also needed to c<strong>on</strong>firm the results.<br />

C<strong>on</strong>clusi<strong>on</strong>s<br />

Overall, we showed that this type <str<strong>on</strong>g>of</str<strong>on</strong>g> massage was able to<br />

significantly reduce c<strong>on</strong>duct problems and anxiety in <str<strong>on</strong>g>Thai</str<strong>on</strong>g><br />

autistic children. Therefore, we c<strong>on</strong>cluded that TTM could be<br />

used as a complementary therapy for autistic children.<br />

Acknowledgments<br />

This work was funded by the Asia Research Centre,<br />

Chulal<strong>on</strong>gkorn University. We would like to thank all the<br />

participants, parents, and teachers for their involvement in<br />

the study. Source <str<strong>on</strong>g>of</str<strong>on</strong>g> support: Grant #009=2549.<br />

Disclosure Statement<br />

No competing financial interests exist.<br />

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Address corresp<strong>on</strong>dence to:<br />

Krisna Piravej, M.D.<br />

Department <str<strong>on</strong>g>of</str<strong>on</strong>g> Rehabilitati<strong>on</strong> Medicine<br />

Faculty <str<strong>on</strong>g>of</str<strong>on</strong>g> Medicine<br />

Chulal<strong>on</strong>gkorn University<br />

Bangkok 10330<br />

<str<strong>on</strong>g>Thai</str<strong>on</strong>g>land<br />

E-mail: knpiravej@hotmail.com


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