CURRICULUM VITAE - Department of Pharmacy
CURRICULUM VITAE - Department of Pharmacy
CURRICULUM VITAE - Department of Pharmacy
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Personal Particulars<br />
Name: HO Han Kiat<br />
Address: Block S4, #03-03<br />
18 Science Drive 4<br />
Singapore 117543<br />
Tel: 65-65167963<br />
<strong>CURRICULUM</strong> <strong>VITAE</strong><br />
HO HAN KIAT<br />
Email: phahohk@nus.edu.sg<br />
Job Title: Assistant Pr<strong>of</strong>essor, <strong>Department</strong> <strong>of</strong> <strong>Pharmacy</strong>, NUS<br />
Secondary: Adjunct Investigator, IMB, A*STAR<br />
Education and Qualification<br />
July 1996 to May 2000: BSc.(<strong>Pharmacy</strong>) 1 st Class Honors<br />
1<br />
Ho Han Kiat<br />
Updated: January 2013<br />
Sep 2000 to Oct 2005: Ph.D. (Medicinal Chemistry), University <strong>of</strong><br />
Washington, USA
Scholarships and Awards<br />
1999: Lee Kuan Yew Gold Medal<br />
1999: Chalmers Medal<br />
1996-1999: Five times recipient <strong>of</strong> Dean’s List award<br />
1999: Glaxo Wellcome Overseas Training Scheme<br />
2<br />
Ho Han Kiat<br />
Updated: January 2013<br />
2000-2005: Overseas Graduate Scholarship with the Agency for<br />
Science, Technology and Research (A*STAR)<br />
2004: Merck Award/scholarship (Dept <strong>of</strong> Medicinal Chemistry, Univ<br />
<strong>of</strong> Washington)<br />
2005: Carl Smith Award- Honorable mention<br />
2009-2012: Three-time recipient <strong>of</strong> Faculty Teaching Excellence Award<br />
2009-2012: Two-time recipient <strong>of</strong> Annual Teaching Excellence Award<br />
Pr<strong>of</strong>essional Experiences:<br />
May 2000-Aug 2000: Research assistant at the <strong>Department</strong> <strong>of</strong> <strong>Pharmacy</strong>,<br />
National University <strong>of</strong> Singapore.<br />
Fall 2001: Teaching assistant for Medicinal Chemistry course<br />
for pharmacy students (MEDCH 402, Medicinal<br />
chemistry <strong>of</strong> anticancer agents and vitamins).<br />
Spring 2003: Teaching assistant for Medicinal Chemistry course<br />
for pharmacy students (MEDCH 401, Immunizing and<br />
antimicrobial agents)<br />
Dec 2005-present: Research fellowship at the Institute <strong>of</strong> Medical<br />
Biology (Lab <strong>of</strong> Pr<strong>of</strong>. Axel Ullrich), Promoted to<br />
Senior Research Fellow in Dec 2007 and appointed<br />
Project Leader in Aug 2008<br />
July 2007-2009: Adjunct assistant pr<strong>of</strong>essor at the <strong>Department</strong> <strong>of</strong><br />
<strong>Pharmacy</strong>, National University <strong>of</strong> Singapore
3<br />
Ho Han Kiat<br />
Updated: January 2013<br />
July 2009-present: Full-Member, Toxicology Division, Office <strong>of</strong> Life<br />
Science, National University <strong>of</strong> Singapore<br />
July 2009-present: Assistant pr<strong>of</strong>essor at the <strong>Department</strong> <strong>of</strong> <strong>Pharmacy</strong>,<br />
National University <strong>of</strong> Singapore<br />
Jan 2011-present: Member <strong>of</strong> the Management Committee <strong>of</strong> the Drug<br />
Development Unit at the National University <strong>of</strong><br />
Singapore<br />
Mar 2011-present: Member (alternate) IACUC Review Board at the<br />
National University <strong>of</strong> Singapore<br />
Jul 2011-present Resident Fellow at Raffles Hall, National University<br />
<strong>of</strong> Singapore<br />
Jul 2012-present: Editorial Member, Signpost Open Access Journal <strong>of</strong><br />
Pathobiology and Toxicology<br />
Apr 2012-April 2014 External Examiner, School and Chemical and Life<br />
Sciences, Ngee Ann Polytechnic<br />
Supervisory Experiences:<br />
1. Research team leader:<br />
Sharon Pok, Lab <strong>of</strong>ficer (2006-2008)<br />
Loo Hooi Linn, Lab <strong>of</strong>ficer (2005-2007)<br />
Tay Liang Seah, Senior research <strong>of</strong>ficer (2007-09)<br />
Priscilla Foo, Senior research <strong>of</strong>ficer (2007-8)<br />
Winnie Wong, Lab <strong>of</strong>ficer (2007-12)<br />
Lim Kah Suan, Intern (2006, 2008)<br />
Ong Hui Min (2008-2009)<br />
Ervinna Pang (2009-10)<br />
Teo Yi Ling, Research assistant (2011)<br />
Chew Yun Shan, Research assistant (2011-12)<br />
Angie Yeo, Research assistant (2011-)<br />
Ho Jia Pei, Research assistant (2012-)<br />
2. Final year project (FYP) supervisor:<br />
Lim Kah Suan, NTU BSc Biological Sciences (2007-2008)<br />
Poh Weijie, NUS BSc (Life Science) Honours (2008-09)<br />
Oh Jing Wen, NUS BSc (<strong>Pharmacy</strong>) (2008-09)
Lee Chern Yih, NUS BSc (<strong>Pharmacy</strong>) (2009-10)<br />
Vivian Teo, NUS BSc (<strong>Pharmacy</strong>) (2009-10)<br />
Joanne Sng, NUS BSc (<strong>Pharmacy</strong>) (2009-10)<br />
Debra Chan, NUS BSc (<strong>Pharmacy</strong>) (2010-11)<br />
Tan An Gie, NUS BSc (<strong>Pharmacy</strong>) (2010-11)<br />
Edwin Tan, NUS BSc (<strong>Pharmacy</strong>) (2010-11)<br />
Gavin Cheah, NUS BSc (<strong>Pharmacy</strong>) (2011-12)<br />
Jonathan Goh, NUS BSc (<strong>Pharmacy</strong>) (2011-12)<br />
Ng Hui Wen, NUS BSc (<strong>Pharmacy</strong>) (2011-12)<br />
Loh Kep Yong, Univ <strong>of</strong> London B(Pharm) (2012)<br />
Hazel Chia, NUS BSc (<strong>Pharmacy</strong>) (2012-13)<br />
Vivien Tham, NUS BSc (<strong>Pharmacy</strong>) (2012-13)<br />
Wee Hui Ling, NUS BSc (<strong>Pharmacy</strong>) (2012-13)<br />
3. PhD supervisor:<br />
Phua Lee Cheng (2009-)<br />
Duan Yan (2009-11, graduated with MSc)<br />
Pang Yi Yun (2010-)<br />
Tan Cheau Yih (2010-)<br />
Zhao Chun Yan (2011-)<br />
Co-supervisor for another 3 graduate students (2007-)<br />
4. PhD committee member:<br />
Leow Pay Chin, Dept <strong>of</strong> <strong>Pharmacy</strong>, NUS (2008-2011)<br />
Tian Quan, Dept <strong>of</strong> <strong>Pharmacy</strong>, NUS (2008-2010)<br />
Liew Chin Yee, Dept <strong>of</strong> <strong>Pharmacy</strong> (2009-2011)<br />
Amrita Nagle, Dept <strong>of</strong> <strong>Pharmacy</strong> (2010-)<br />
Sun Lingyi, Dept <strong>of</strong> <strong>Pharmacy</strong> (2010-)<br />
Rosita Koh, Dept <strong>of</strong> Pathology (2011-)<br />
Ekarin Chulikorn, Dept <strong>of</strong> Biochemistry (2011-)<br />
Jaymie Lin Siqi, Dept <strong>of</strong> Medicine (2011-)<br />
Zhang Luqi, Dept <strong>of</strong> <strong>Pharmacy</strong> (2012-)<br />
Training:<br />
4<br />
Ho Han Kiat<br />
Updated: January 2013<br />
May 1997-Jun 1997: Attachment at Changi General Hospital, Singapore,<br />
as pharmacy assistant.<br />
Jun 1999-Jul 1999: Overseas industrial internship at Glaxo Smithkline<br />
Australia.
5<br />
Ho Han Kiat<br />
Updated: January 2013<br />
Jul-Aug 2001: Industrial Internship at S*Bio Pte Ltd, a<br />
pharmaceutical research firm in Singapore.<br />
Jan 2007: Participant in the EMBO lab management course in<br />
Heidelberg, Germany<br />
June 2007: Participant in an A*STAR organized Team<br />
Effectiveness Course<br />
Jan 2008: Participant at the Performance Management<br />
Programme (SDC Consulting)<br />
April 2009: Participant at the Mid-American Toxicology Course<br />
in Kansas City, MO, USA<br />
Aug 2009-Dec 2011: Completed Pr<strong>of</strong>essional Development Programme<br />
(Teaching) at CDTL, NUS.<br />
Invited Speaker:<br />
Jun 1999: Speaker at the 4 th South East Asian Pharmaceutical<br />
Students’ Society Congress at Cebu, The Philippines.<br />
Title: Public Awareness <strong>of</strong> Diabetes Mellitus in<br />
Singapore.<br />
Jun 2004: Invited speaker for a research seminar at the<br />
Genome Institute <strong>of</strong> Singapore. Title: Mechanisms <strong>of</strong><br />
tetrafluoroethylcysteine cytotoxicity.<br />
Jun 2004: Invited speaker for a research seminar at the 2 nd<br />
Annual Merck Graduate Student Symposium at West<br />
Point, PA, USA. Title: Mechanisms <strong>of</strong><br />
tetrafluoroethylcysteine cytotoxicity.<br />
Jan 2006: Invited speaker at the 2 nd AAPS-NUS Student<br />
Chapter Symposium. Title: An investigation <strong>of</strong> cellular<br />
responses to tetrafluoroethylcysteine-induced<br />
mitochondrial dysfunction.<br />
Apr 2006: Invited speaker at the General Surgery Research<br />
Conference at Tan Tock Seng Hospital. Title: Drug-
6<br />
Ho Han Kiat<br />
Updated: January 2013<br />
induced hepatotoxicity and hepatocellular carcinoma:<br />
A basic science approach<br />
May 2007: Oral presentation <strong>of</strong> research project at Schloss<br />
Ringberg, Germany. Title: SOG project extension:<br />
Exploring the role <strong>of</strong> tyrosine kinases in hepatocellular<br />
carcinoma<br />
Oct 2007: Invited speaker for AAPS-NUS student chapter<br />
workshop. Title: Back to the future with toxicological<br />
sciences: Impact on the art <strong>of</strong> pharmacy<br />
Nov 2007: Invited speaker for the A*STAR Young Scientist<br />
Workshop on Cancer. Title: The involvement <strong>of</strong><br />
FGFR4 on hepatocellular carcinoma<br />
May 2008: Speaker for IMB seminar series. Title: FGFR4 in<br />
hepatocellular carcinoma: An emerging target for a<br />
surging disease.<br />
Nov 2008: Invited speaker for 1 st HCC Workshop by Singapore<br />
Institute <strong>of</strong> Clinical Sciences/Singapore Immunology<br />
Network. Title: The role <strong>of</strong> FGFR4 in hepatocellular<br />
carcinoma.<br />
Jan 2009: Faculty Lecture at <strong>Department</strong> <strong>of</strong> <strong>Pharmacy</strong>, NUS.<br />
Title: Tyrosine kinase inhibitors in HCC: An over-rated<br />
regimen or under-developed rudiment?<br />
Jun 2009: Invited speaker at Max-Planck Institute for<br />
Biochemistry Annual Symposium at Schloss<br />
Ringberg, Germany. Title: Tyrosine kinase inhibitors<br />
in HCC: An over-rated regimen or under-developed<br />
rudiment?<br />
Jul 2009: Invited speaker at the Singapore <strong>Pharmacy</strong><br />
Congress 2010. Title: Drug development and<br />
toxicology.<br />
Mar 2010: Invited speaker at the 3 rd Pep-Con 2010 at Beijing,<br />
China. Title: Exploring FGFR4 as a potential target for<br />
the treatment <strong>of</strong> hepatocellular carcinoma.<br />
Apr 2010: Invited speaker at Faculty Teaching Workshop,<br />
NUS. Title: Incorporating research into teaching: A<br />
case study.
7<br />
Ho Han Kiat<br />
Updated: January 2013<br />
Apr 2010: Invited speaker at the 6 th AAPS-NUS Student<br />
Chapter Scientific Symposium. Title: Laboratory <strong>of</strong><br />
liver cancer and drug-induced liver toxicity research.<br />
May 2010: Invited speaker at the NUS-AAPS<br />
PharmSci@Vietnam 2010, Ho Chi Minh City<br />
Symposium, Vietnam. Title: Exploring multi-kinase<br />
targeting inhibitors for the treatment <strong>of</strong> hepatocellular<br />
carcinoma.<br />
May 2010: Invited speaker at the NUS-AAPS<br />
PharmSci@Shanghai 2010, Fudan University, China.<br />
Title: Exploring multi-kinase targeting inhibitors for the<br />
treatment <strong>of</strong> hepatocellular carcinoma.<br />
Jun 2010: Invited speaker at the 3 rd World Cancer Congress in<br />
Singapore. Title: Exploring multi-kinase targeting<br />
inhibitors for the treatment <strong>of</strong> hepatocellular<br />
carcinoma.<br />
Sep 2010: Invited speaker at the NUS <strong>Pharmacy</strong> Medicinal<br />
Chemistry Symposium. Title: Phenotype-based<br />
screening approach to uncover new multi-targeting<br />
kinase inhibitors<br />
Jun 2011: Invited speaker and session chair at the<br />
International Conference on Materials for Advanced<br />
Technologies 2011, Singapore. Title: Extrapolating<br />
safety assessment methods from drug discovery to<br />
nanomaterials: Opportunities and pitfalls.<br />
Jul 2011: Invited speaker at the Max-Planck Institute for<br />
Biochemistry. Title: Benzylidine-indolinones as<br />
therapeutics against against hepatocellular<br />
carcinoma: Kinase inhibitors and beyond.<br />
Jul 2011: Invited speaker at Vichem Corporation. Title: An<br />
overview <strong>of</strong> structure toxicity relationship: Implications<br />
on drug design.<br />
Jan 2012: Invited speaker at the <strong>Pharmacy</strong> Teaching<br />
Workshop: Stimulating learning with applicationbased<br />
assessments.
8<br />
Ho Han Kiat<br />
Updated: January 2013<br />
May 2012: Invited speaker at Vichem Corporation. Title:<br />
Development <strong>of</strong> novel FGFR4 inhibitor<br />
Jan 2012: Invited facilitator for microteaching session at the<br />
CDTL training for teaching assistants.<br />
July 2012: Invited speaker at the CDTL workshop series:<br />
Motivating students using a student-centric approach<br />
Sep 2012: Invited speaker at the SG-GCP course by NHG R&D<br />
Office: Introduction to Drug Development Process<br />
Sep 2012: Speaker at the 8 th Congress in Toxicology for<br />
Developing Countries, Bangkok, Thailand. Title:<br />
Understanding the mechanism <strong>of</strong> lapatinib-induced<br />
hepatotoxicity: An in vitro-in vivo investigation<br />
Nov 2012: Invited speaker at CDTL Postgraduate Seminar<br />
Series. Title: Components <strong>of</strong> a Research Paper<br />
Nov 2012: Invited speaker at School <strong>of</strong> Design and<br />
Environment, NUS. Title: Engaging students through<br />
application-based assessments.<br />
Feb 2013: Invited speaker at Asia Pacific Association for the<br />
Study <strong>of</strong> the Liver (APASL) Annual Meeting,<br />
Singapore. Title: Exploring the use <strong>of</strong> mesenchymal<br />
stem cell-derived exosomes in drug-induced liver<br />
injury.<br />
Invited reviewer:<br />
Journals:<br />
1. Am J Pathology (1)<br />
2. Biochemical Pharmacology (21)<br />
3. BMC Cancer (1)<br />
4. Cancer Research (1)<br />
5. Curr Pharm Biotech (1)<br />
6. Expert Opin Drug Metab Toxicol (1)<br />
7. Human Immunology (1)<br />
8. J Drug Delivery (1)<br />
9. J Pediatric Surgery (1)<br />
10. J Toxicology and Environmental Health Sciences (1)<br />
11. Toxicological Sciences (2)<br />
12. African Journal <strong>of</strong> <strong>Pharmacy</strong> and Pharmacology (1)
13. Journal <strong>of</strong> Oncology <strong>Pharmacy</strong> Practice (1)<br />
14. Biomatters (1)<br />
15. Materials Letters (1)<br />
16. Biotechnology Advances (1)<br />
17. J Biotechnology (1)<br />
Publications (Posters/Abstracts)<br />
9<br />
Ho Han Kiat<br />
Updated: January 2013<br />
1. Hu ZH, Ho HK, Bammler TK, Kavanagh TJ, Fausto N, Nelson SD, Bruschi<br />
SA. Toxicologist 66, LB66 (2002). Genomic responses to specific<br />
intramitochondrial damage.<br />
2. Ho HK, Hu ZH, Tzung, SP, Hockenbery DM, Fausto N, Nelson SD,<br />
Bruschi SA. Toxicologist 72, Abstract 1558 (2003). Inhibition <strong>of</strong> BAX<br />
translocation and necrosis with BCL-xL overexpression in a well<br />
characterized cell culture model for tetrafluoroethylcysteine-induced<br />
nephrotoxicity.<br />
3. Ho HK, Jia YK, Hu ZH, Hockenbery DM, Fausto N, Nelson SD, Bruschi<br />
SA. Toxicologist 78, Abstract 253 (2004). Heat shock protein responses in<br />
tetrafluoroethylcysteine-induced cytotoxicity.<br />
4. Ho HK, White CC, Fernandez C, Kavanagh TJ, Fausto N, Nelson SD,<br />
Bruschi SA. Toxicologist 82, Abstract 813 (2005). Nrf2 activation involves<br />
an oxidative-stress independent pathway in tetrafluoroethylcysteineinduced<br />
cytotoxicity.<br />
5. Ho HK, Pok S, Ruhe JE, Streit SS, Hart S, Foo P, Loo HL, Aung MO,<br />
Ullrich A, Lim SG. Molecular Targets and Cancer Therapeutics, Abstract<br />
C73 (2007). Exploring the involvement <strong>of</strong> FGFR4 in hepatocellular<br />
carcinoma.<br />
6. Ho HK, Pok S, Streit SS, Ruhe JE, Hart S, Loo HL, Lim KS, Aung MO,<br />
Lim SG, Ullrich A. Liver Growth, Development and Disease, Abstract 15<br />
(2008). FGFR4 Regulates Proliferation, Anti-apoptosis and Alphafetoprotein<br />
Secretion During Hepatocellular Carcinoma Progression and<br />
Represents a Potential Target for Therapeutic Intervention<br />
7. Foo P, Ho HK, Streit S, Ruhe JE, Hart S, Ullrich A. Molecular Targets and<br />
Cancer Therapetuics, Abstract 361 (2008). FGFR4 Y367C: Contributes to<br />
a constitutively active FGFR4 and tumor aggressiveness in breast cancer<br />
cell line.
10<br />
Ho Han Kiat<br />
Updated: January 2013<br />
8. Ho HK, Wong W, Lim KS, Zhang W, Go ML, Ullrich A. Biopharma Asia<br />
Convention (2010). Benzylidine-indolinones are effective multi-targeted<br />
kinase inhibitor therapeutics against hepatocellular carcinoma.<br />
9. Chan CYE, Oh JW, New LS, Ho HK. 3rd Asia Pacific Regional ISSX<br />
Meeting (2009), Drug Metabolism Reviews, 41, S2:89. Investigating the<br />
molecular mechanism <strong>of</strong> lapatinib-induced liver toxicity.<br />
10. Saha S, New LS, Ho HK, Chui WK, Chan CYE. 3rd Asia Pacific Regional<br />
ISSX Meeting 2009, Drug Metabolism Reviews, 41, S2:26. Investigation <strong>of</strong><br />
the role <strong>of</strong> thiazolidinedione <strong>of</strong> troglitazone in inducing hepatotoxicity in<br />
humans.<br />
11. Duan Y, Wong W, Poh W, Chua BT, Ho HK. Asia Pacific Association for<br />
the Study <strong>of</strong> Liver Annual Meeting 2011. Overexpression <strong>of</strong> Tyro3 and the<br />
implications on HCC progression.<br />
12. Tan CY, Lai RC, Lin SQ, Dan YY, Lim SK, Ho HK. Asia Pacific<br />
Association for the Study <strong>of</strong> Liver Annual Meeting 2011. Exploring<br />
mesenchymal stem cell derived exosome as a hepatoprotective agent for<br />
the treatment <strong>of</strong> drug-induced liver injury.<br />
13. Pang YY, Go ML, Ho HK. Toxicologist 126, Abstract 342 (2012). A<br />
structure-toxicity-relationship investigation <strong>of</strong> 2-phenylamino-phenylacetic<br />
acid analogs<br />
14. Phua LC, Koh PK, Cheah PY, Yip LY, Sampathkumar A, Tan YM, Ho HK,<br />
Chan ECY. 12th European International Society for the Study <strong>of</strong><br />
Xenobiotics Meeting. Global gas chromatography/time-<strong>of</strong>-flight mass<br />
spectrometry (GC/TOFMS)-based metabotyping <strong>of</strong> lyophilized human<br />
feces.<br />
15. Phua LC, Mainak M, Cheah PY, Koh PK, Ho HK, Chan ECY. 2013<br />
Gastrointestinal Cancers Symposium, San Francisco, CA, USA. Global<br />
pr<strong>of</strong>iling <strong>of</strong> fecal and tissue miRNAs in Asian Chinese colorectal cancer<br />
patients.<br />
16. Tan CY, Lai RC, Lin SQ, Dan YY, Lim SK, Ho HK. International Society for<br />
the Study <strong>of</strong> Xenobiotics Annual Meeting, Dallas, TX, USA. Exploring<br />
mesenchymal stem cell derived exosome as a hepatoprotective agent in<br />
drug-induced acute liver injury.<br />
Publications (Research papers)
11<br />
Ho Han Kiat<br />
Updated: January 2013<br />
1. Wee HL, Ho HK, Li SC. Singapore Med J, 43, 128-34 (2002). Public<br />
awareness <strong>of</strong> diabetes mellitus in Singapore.<br />
2. Ho HK (Corresponding author), Hu ZH, Tzung SP, Hockenbery DM,<br />
Fausto N, Nelson SD, Bruschi, SA. Biochemical Pharmacology, 69, 147-<br />
157 (2005). BCL-xL overexpression effectively protects against<br />
tetrafluoroethylcysteine-induced intramitochondrial damage and cell death.<br />
3. Ho HK (Corresponding author), White CC, Fernandez C, Kavanagh TJ,<br />
Fausto N, Nelson SD, Bruschi SA. Toxicological Sciences, 86, 354-364<br />
(2005). Nrf2 activation involves an oxidative-stress independent pathway<br />
in tetrafluoroethylcysteine-induced cytotoxicity.<br />
4. Ho HK, Jia YK, Coe KJ, Gao Q, Doneanu CE, Hu ZH, Bammler TK, Beyer<br />
RP, Fausto N, Bruschi SA, Nelson SD. Biochemical Pharmacology, 72,<br />
80-90 (2006). Cytosolic heat shock proteins and heme oxygenase-1 are<br />
preferentially induced in response to specific and localized<br />
intramitochondrial damage by tetrafluoroethylcysteine.<br />
5. Boelsterli UA, Ho HK, Zhou SF, Leow KY. Current Drug Metabolism, 7,<br />
715-727 (2006). Bioactivation and hepatotoxicity <strong>of</strong> nitroaromatic drugs.<br />
6. Coe, KJ, Jia Y, Ho HK, Rademacher P, Bammler TK, Beyer RP, Farin FM,<br />
Woodke L, Plymate SR, Fausto N, Nelson SD. Chem Res Tox, 20, 1277-<br />
1290 (2007). Comparison <strong>of</strong> the cytotoxicity <strong>of</strong> the nitroaromatic drug<br />
flutamide to its cyano analog in the hepatocyte cell line TAMH: Evidence<br />
for complex I inhibition and mitochondrial dysfunction using toxicogenomic<br />
screening.<br />
7. Ruhe JE, Streit SS, Hart S, Wong CH, Specht K, Knyazev P, Knyazeva K,<br />
Tay LS, Loo HL, Foo P, Wong W, Pok S, Lim SJ, Ong HM, Luo M, Ho HK,<br />
Peng K, Lee TC, Bezler M, Mann C, Gaertner S, Hoefler H, Iacobelli S,<br />
Peter S, Tay A, Brenner S, Venkatesh B, Ullrich A. Cancer Res, 67,<br />
11368-11376 (2007). Genetic alterations in the tyrosine kinase<br />
transcriptome <strong>of</strong> human cancer cell lines.<br />
8. Ho HK (Corresponding author), Pok S, Streit SS, Ruhe JE, Hart S, Loo<br />
HL, Lim KS, Aung MO, Lim SG, Ullrich A. J Hepatology, 50, 118-127<br />
(2009). FGFR4 Regulates Proliferation, Anti-apoptosis and Alphafetoprotein<br />
Secretion During Hepatocellular Carcinoma Progression and<br />
Represents a Potential Target for Therapeutic Intervention.<br />
9. Saha S, New LS, Ho HK, Chui WK, Chan ECY. Tox Letters, 192, 141-149<br />
(2010). Investigation <strong>of</strong> the role <strong>of</strong> thiazolidinedinone ring <strong>of</strong> troglitazone in<br />
inducing hepatotoxicity
12<br />
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Updated: January 2013<br />
10. Roidl A, Foo P, Mann C, Bechtold S, Berger HJ, Streit S, Ruhe JE, Hart S,<br />
Ullrich A, Ho HK (Corresponding author). Oncogene, 29, 1543-1552<br />
(2010). The FGFR4 Y367C Mutant is a Dominant Oncogene in MDA-<br />
MD453 Breast Cancer Cells.<br />
11. Saha S, New LS, Ho HK, Chui WK, Chan ECY. Tox Letters, 195(2-3),<br />
135-141 (2010). Direct toxicity effects <strong>of</strong> sulfo-conjugated troglitazone on<br />
human hepatocytes.<br />
12. Teng WC, Oh JW, New LS, Wahlin MD, Nelson SD, Ho HK and Chan<br />
CYE. Mol Pharmacol, 78, 693-703 (2010). Mechanism-based inactivation<br />
<strong>of</strong> Cytochrome P450 3A4 by lapatinib.<br />
13. Nayak T, Li J, Phua LC, Ho HK, Ren Y, Pastorin G. ACS Nano, 4(12),<br />
7717-25 (2010). Thin films <strong>of</strong> functionalized multi-walled carbon<br />
nanotubes as suitable scaffold materials for stem cells proliferation and<br />
bone formation.<br />
14. Chan CY, New LS, Ho HK, Chan EC. Tox Letters, 206(3), 314-24 (2011).<br />
Reversible time-dependent inhibition <strong>of</strong> CYP450 enzymes by duloxetine<br />
and the inertness <strong>of</strong> its thiophen ring towards bioactivation.<br />
15. Teo YL, Saetaew M, Chanthawong S, Yap YS, Chan EC, HO HK, Chan A.<br />
Breast Cancer Res Treat, 133(2), 703-711 (2012). Effect <strong>of</strong> CYP3A4<br />
inducer dexamethasone on hepatotoxicity <strong>of</strong> lapatinib: clinical and in vitro<br />
evidence.<br />
16. Poh W, Wong W, Ong H, Aung MO, Lim SG, Chua BT, Ho HK<br />
(Corresponding author). Mol Cancer, 11:14 (2012). Klotho-beta<br />
overexpression as a novel target for suppressing proliferation and<br />
fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma.<br />
17. Chan EC, New LS, Chua TB, Yap CW, Ho HK, Nelson SD. Drug Metab<br />
Disp, 40(7), 1414-1422 (2012). Interaction <strong>of</strong> lapatinib with cytochrome<br />
P450 3A5.<br />
18. Tian Q, Wong W, Xu Y, Chan Y, Ho HK, Pastorin G, Ang WH. Chem<br />
Comm, 48(44), 5467-5469 (2012). Immobilisation <strong>of</strong> quantum dots by bioorthogonal<br />
PCR amplification and labeling for direct gene detection and<br />
quantification.<br />
19. Chng HT, Ho HK, Yap CW, Lam SH, Chan EC. J Biomol Screen, 17(7),<br />
974-986 (2012). An investigation <strong>of</strong> the bioactivation potential and<br />
metabolism pr<strong>of</strong>ile <strong>of</strong> zebrafish versus human.
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Ho Han Kiat<br />
Updated: January 2013<br />
20. Zhao C, Tan A, Pastorin G, Ho HK. Biotech Adv, E published (2012).<br />
Nanomaterial scaffolds for stem cell differentiation and proliferation in<br />
tissue engineering.<br />
21. Saha S, Chan DS, Lee CY, Wong W, Yap CW, Chui WK, Chan EC, Ho<br />
HK. Eur J Pharmacol 697(1-3), 13-23 (2012). Pyrrolidinediones reduce the<br />
toxicity <strong>of</strong> thiazolidinediones and modify their anti-diabetic and anti-cancer<br />
properties.<br />
22. Teo YL, Ho HK, Chan A. Cancer Treat Rev 39(2), 199-206 (2013). Risk <strong>of</strong><br />
tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: A<br />
meta-analysis.<br />
23. Phua LC, Mal M, Koh PK, Cheah PY, Chan EC, Ho HK. Cancer<br />
Chemother Pharmacol E-published (2012). Investigating the role <strong>of</strong><br />
nucleoside transporters in the resistance <strong>of</strong> colorectal cancer to 5fluorouracil<br />
therapy.<br />
24. Chan A, Ho HK, Cheung YT, Teo YL. Adv Pharmacoepidem Drug Safety,<br />
1:5 (2012). Supportive care in cancer patients: Current challenges and<br />
opportunities.<br />
Patents<br />
1. PCT International Application No. PCT/SG2007/000412 for the invention<br />
entitled, “Cancer-Related Protein Kinases”<br />
2. PCT International Application No. PCT/SG2009/000376 for invention<br />
entitled, “A Novel Benzylidene-indolinone (Compound 47) as a Multitargeted<br />
Tyrosine Kinase Inhibitor with Potent Anti-cancer Properties<br />
Against Liver Cancer”<br />
3. US Provisional Application number 61/514,950 “Benzylidene-indolinone<br />
and their medical uses”.<br />
Research Grants<br />
1. Faculty <strong>of</strong> Science, Start-up Grant: “Exploring the role <strong>of</strong> receptor tyrosine<br />
kinase Tyro3 in Hepatocellular Carcinoma”, Sep 2009-Aug 2012,<br />
$180,000 (Role: PI)<br />
2. NMRC New Investigator Grant: “Exploring Mesenchymal Stem Cellderived<br />
Conditioned Medium as Hepatoprotective Agents Against Druginduced<br />
Liver Injuries”, Nov 2009-Nov 2011, $170,000 (Role: PI)
14<br />
Ho Han Kiat<br />
Updated: January 2013<br />
3. Faculty <strong>of</strong> Science, FRC Grant: “Molecular pr<strong>of</strong>iling <strong>of</strong> fecal microRNAs for<br />
the detection <strong>of</strong> colorectal cancer”, May 2010-Apr 2013, $175,000 (Role:<br />
PI)<br />
4. A*STAR TSRP Integrated Nano-photo-bio interface grant: “Quantum dotbased<br />
micr<strong>of</strong>luidic device for determining etiology <strong>of</strong> rhinitis”. May 2010-<br />
Apr 2013, $902,510 (Role: Co-PI)<br />
5. A*STAR-SSCC grant: “Systematic characterization <strong>of</strong> the intrinsic drug<br />
metabolizing capacity <strong>of</strong> hepatocytes differentiated from stem cells”, Sep<br />
2010-Aug 2013, $243,783 (Role: Co-PI)<br />
6. A*STAR-NKTH Grant, “Development <strong>of</strong> Small Molecule Inhibitors <strong>of</strong><br />
FGFR4 and ACK1”, Sep 2009-Aug 2012, $530,000 (Role: Collaborator)<br />
7. Singapore Cancer Society Cancer Research Grant, “Optimization <strong>of</strong> a<br />
Dosage Regimen for sunitinib in metastatic renal cell carcinoma treatment<br />
through pharmacokinetic monitoring to achieve better efficacy and safety<br />
pr<strong>of</strong>ile”, Jan 2011-Jan 2012, $99,700 (Role: Collaborator)