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Original Research Article ABSTRACT - GJRMI - Global Journal of ...

Original Research Article ABSTRACT - GJRMI - Global Journal of ...

Original Research Article ABSTRACT - GJRMI - Global Journal of

www.gjrmi.com GJRMI, Volume 1, Issue 8, August 2012, 340–351 Global Journal of Research on Medicinal Plants & Indigenous Medicine Original Research Article EVALUATION OF ANTI ULCER ACTIVITY OF FICUS PUMILA L. LEAF EXTRACT IN ALBINO RATS. Muhammed Ashraf V K 1 , Thamotharan G 2 *, Sengottuvelu S 3 , Haja Sherief S 4 , Sivakumar T 5 1,2,3,4,5 Department of Pharmacology, Nandha College of Pharmacy and Research Institute, Erode - 52, Tamilnadu, India *Corresponding author: Mob:-+91 90 2526 5999; Email: jthams0309@gmail.com ABSTRACT Received: 22/06/2012; Revised: 28/07/2012; Accepted: 30/07/2012 The objective of this study was to investigate the gastro protective activity of ethanolic extract of leaves of Ficus pumila L. (Moraceae) in different experimental models of gastric ulcer in rats. Two doses (200 mg/kg and 400 mg/kg) of the extracts were used for the study. The experimental ulcers were induced by different models such as pyloric ligation, ethanol and cold restrained ulcer models. Omeprazole (10 mg/kg) and sucralfate 100 mg/kg) were used as the standard drugs. All drugs were administered by the oral route. The ulcer index and percentage of ulcer protection were measured. Phytochemical tests and various parameters such as free acidity, total acidity, total hexose, Hexosamine, Fucose and total protein were measured. The result showed that administration of the extract of Ficus pumila L. to the Albino rats significantly decreases the ulcer index with increase in the percentage of ulcer protection in a dose dependent manner when compared with control groups. Phyto-chemical analysis revealed the presence of carbohydrate, glycosides, sterols, flavonoids and triterpenes. It could be concluded that the ethanolic extract of leaves of Ficus pumila possess significant, dose dependent anti ulcer activity. KEYWORDS: Anti-ulcer, Ficus pumila L., pyloric ligation, ethanolic extract, ethanol, cold restraint Ulcer.

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