Partec Reagents & mAb Catalog

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List of mouse monoclonal antibodies 4 List of mouse monoclonal antibodies (Please contact us for further information on antibodies not listed here)
sPecificity format order no. Qty isotyPe clone reactivity examPle cd1a FITC 05-7-123F 1 ml* IgG1 HI149 Hu PE 05-7-123P 1 ml* APC 05-7-123A 1 ml* comment CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent on vesicular acidification. The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with beta2microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukaemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. cd2 FITC 05-7-393F 1 ml* IgG2a LT2 Hu PE 05-7-393P 1 ml* APC 05-7-393A 1 ml* FITC 05-7-502F 1 ml* IgG1 HIT11 Hu PE 05-7-502P 1 ml* comment CD2 is a member of the immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cellcell interface to provide tight adhesion. Moreover T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. The antibody LT2 reacts with CD2, a 50 kDa glycoprotein present on human peripheral blood T and NK cells and is also expressed by all thymocytes. The antibody HIT11 recognises a 50-kDa type-I single-chain transmembrane glycoprotein called LFA-2 (lymphocyte function associated antigen-2) or sheep red blood cell (SRBC) receptor. The CD2 antigen is expressed on 70-80% of peripheral blood lymphocytes and 80%-90% of thymocytes and NK cells. The primary ligand for CD2 is CD58 (LFA-3) despite binding to CD48, CD59 and CD15. The CD2 antigen plays a role in T cell signaling and in lymphocyte adhesion, and is an alternative pathway of T cell activation. There are two forms of CD2, a membrane form on cell surface and a soluble form in serum. *for 50 tests Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine List of mouse monoclonal antibodies 5
Page 1 and 2: Reagents illuminated by Partec. emi
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Page 41 and 42: sPecificity clone-isotyPe fluorochr
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Page 45 and 46: Antibody premix for triple staining
Page 47 and 48: cd4 easy count kit cd4% easy count
Page 49 and 50: cd3 easy count kit cd8 easy count k
Page 51 and 52: cylyse® 05-5010 200 tests control
Page 53 and 54: tm 05-6001 30 tests oenoyeast yeast
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yeast control neutral lipids yeast
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cystain ® Pi absolute P cystain ®
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cystain ® dna/Protein control bloo
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calibration beads 1 µm concentrate
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countcheck beads countcheck beads g
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Partec sheath fluid sample tubes cl
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Contact Partec GmbH Otto-Hahn-Stra
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