Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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Forschungszentrum Jülich GmbH Institut für Biotechnologie 2 Modeling Based Process Development of Fed-Batch Bioprocesses: L-Valine Production by Corynebacterium glutamicum Michel Brik Ternbach Schriften des Forschungszentrums Jülich Reihe Lebenswissenschaften / Life Sciences Band / Volume 21 ISSN 1433-5549 ISBN 3-89336-413-7
Bibliographic information published by Die Deutsche Bibliothek. Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available in the Internet . Publisher and Forschungszentrum Jülich GmbH Distributor: Zentralbibliothek 52425 Jülich Phone +49 (0)2461 61-5368 · Fax +49 (0)2461 61-6103 e-mail: zb-publikation@fz-juelich.de Internet: http://www.fz-juelich.de/zb Cover Design: Grafische Medien, Forschungszentrum Jülich GmbH Printer: Grafische Medien, Forschungszentrum Jülich GmbH Copyright: Forschungszentrum Jülich 2005 Schriften des Forschungszentrums Jülich Reihe Lebenswissenschaften/Life Sciences Band/Volume 21 D 82 (Diss., Aachen, Univ., 2005) ISSN 1433-5549 ISBN 3-89336-413-7 Neither this book nor any part of it may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
Page 1 and 2: Lebenswissenschaften Life Sciences
Page 6: ’Therefore, mathematical modeling
Page 9 and 10: Contents 3.4. Application: L-Valine
Page 11 and 12: Contents 4
Page 13 and 14: 1. Introduction need for improved m
Page 15 and 16: 2. Theory In a batch process, all s
Page 17 and 18: 2. Theory 1997; Goncalves et al., 2
Page 19 and 20: 2. Theory For batch fermentations,
Page 21 and 22: 2. Theory with Yps being the yield
Page 23 and 24: 2. Theory Inhibition Some catalytic
Page 25 and 26: 2. Theory The method of least squar
Page 27 and 28: 2. Theory evaluation can be made by
Page 29 and 30: 2. Theory We define the measured or
Page 31 and 32: 2. Theory build in the model. An ob
Page 33 and 34: 2. Theory nations, the researcher i
Page 35 and 36: 2. Theory W = J · Covθ · J T (2.
Page 37 and 38: 2. Theory arg max ξ � m� m�
Page 39 and 40: 2. Theory with all measured values
Page 41 and 42: 2. Theory which can be estimated us
Page 43 and 44: 2. Theory One option to account for
Page 45 and 46: 2. Theory θ 2 $θ 2 0 area ≅ det
Page 47 and 48: 2. Theory designed using a paramete
Page 49 and 50: 2. Theory proteome14 (Hermann et al
Page 51 and 52: 2. Theory 44
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3. Dynamic Modeling Framework itera
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3. Dynamic Modeling Framework 3.3.
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3. Dynamic Modeling Framework 3.3.3
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3. Dynamic Modeling Framework 52 du
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3. Dynamic Modeling Framework the c
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3. Dynamic Modeling Framework For d
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3. Dynamic Modeling Framework subse
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3. Dynamic Modeling Framework 60
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4. Simulative Comparison of Model D
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5. L-Valine Production Process Deve
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A. Nomenclature Table A.1.: Symbols
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Table A.1.: Symbols and Abbreviatio
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Table A.1.: Symbols and Abbreviatio
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B. Ratio between OD600 and Dry Weig
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C. The Influence of the Oxygen Supp
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The measurements of amino acids and
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kiv [mM] lac [mM] 15 10 5 0 0 10 20
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OTR, CTR 0.06 0.04 0.02 0 0 10 20 3
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DO properly at a low value in dynam
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D. Dilution for Measurement of Amin
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E. Models used in the First Model D
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Model 1.6 Model 1.6 is similar to m
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Table E.1: Model Parameters of the
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Table E.2: Model Parameters of the
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161
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Model 2.2 Model 2.2 is similar to m
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Table F.1.: Model Parameters of the
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Table F.2.: Estimated Lag-Times of
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Table F.3: Model Parameters of the
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Table F.4.: Estimated Lag-Times of
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G. Alternative Off-line Optimized P
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G.2. Overall Yield of Product on Su
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Summary Fast development of product
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Zusammenfassung Es ist wichtig, die
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Acknowledgements This thesis result
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Bibliography K. Akashi, H. Shibai,
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Bibliography A. Bodalo-Santoyo, J.L
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Bibliography A.J. Cooper, J.Z. Gino
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Bibliography A.G. Fredrickson, R.D.
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Bibliography W.G. Hunter and A.M. R
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Bibliography A.C. McHardy, A. Tauch
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Bibliography E. Radmacher, A. Vaits
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Bibliography K.J. Versyck, J.E. Cla
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Corynebacterium glutamicum - JUWEL - Forschungszentrum Jülich

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