cv_lember_marius (PDF / 162.8 KB) - CellNetworks
cv_lember_marius (PDF / 162.8 KB) - CellNetworks
cv_lember_marius (PDF / 162.8 KB) - CellNetworks
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Dr. Marius Kaspar Lemberg<br />
Date of birth 23.11.1973 in Stuttgart<br />
Scientific Education<br />
Zentrum für Molekulare Biologie der Universität<br />
Heidelberg (ZMBH)<br />
Im Neuenheimer Feld 282<br />
69120 Heidelberg<br />
Germany<br />
Phone: +49-6221-545889; Fax: +49-6221-545893<br />
E-mail: m.<strong>lember</strong>g@zmbh.uni-heidelberg.de<br />
Web page: http://www.zmbh.uni-heidelberg.de/<strong>lember</strong>g/<br />
1997 Undergraduate degree in Biochemistry,<br />
Eberhard-Karls University Tübingen<br />
2000 Diploma of Natural Sciences,<br />
ETH Zürich, Switzerland.<br />
Topic of diploma thesis: Processing of signal peptides in<br />
rough microsomes<br />
2003 Doctor of Natural Sciences, Institute of Biochemistry,<br />
ETH Zürich, Switzerland.<br />
Topic: Intramembrane Proteolysis by the aspartic protease<br />
SPP<br />
2004 - 2007 Postdoctoral fellow with Dr. Matthew Freeman,<br />
MRC Laboratory of Molecular Biology, Cambridge, UK.<br />
Topics: Molecular mechanism of rhomboid-catalysed<br />
proteolysis; Characterization of mammalian rhomboids<br />
2007 - present Junior Group Leader at the ZMBH, University of Heidelberg<br />
Fellowships/Awards<br />
Personal PhD-student fellowship from the Boehringer Ingelheim Fonds (2001)<br />
EMBO long-term fellowship (2003)<br />
Award and Silver Medal for a distinguished PhD thesis, ETH Zürich (2004)<br />
SNF Fellowship for Advanced Researchers (2005)<br />
Filed of current interest<br />
Cell biology and membrane biology; mechanism, regulation and function of proteases; cellular<br />
quality control and cellular stress response<br />
Publications (5 most important are highlighted in bold)<br />
Fleig L., Bergbold N., Sahasrabudhe P., Geiger B., Kaltak L., and Lemberg M.K. (2012)<br />
Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of<br />
Membrane Proteins. Mol. Cell 47, 558-569. Highlighted by News and Views in Nat. Struct.<br />
Mol. Biol., Preview in Dev. Cell and Faculty of 1000<br />
Prod´home V., Tomasec P., Cunningham C., Lemberg M.K., Stanton R.J., et al. (2012)<br />
Human Cytomegalovirus UL40 Signal Sequence Regulates Cell Surface Expression of the<br />
Natural Killer Cell Ligands HLA-E and gpUL18. J. Immunol. 188, 2794-2804.<br />
CV Marius Lemberg page 1
Lemberg, M.K. (2011) Intramembrane proteolysis in regulated protein trafficking. Traffic. 12,<br />
1109-1118. Review.<br />
Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M.K., and Freeman, M. (2011)<br />
Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12,<br />
421-427.<br />
Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D.J., and Lemberg, M.K. (2011) The<br />
mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1<br />
trafficking. J. Neurochem. 117, 856-867.<br />
Lemberg, M.K., and Freeman, M. (2007). Functional and evolutionary implications of<br />
enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17,<br />
1634-1646.<br />
Lemberg, M.K., and Freeman, M. (2007). Cutting proteins within lipid bilayers: rhomboid<br />
structure and mechanism. Mol. Cell. 28, 930-940. Review.<br />
Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M., and Freeman, M. (2005).<br />
Mechanism of intramembrane proteolysis investigated with purified rhomboid<br />
proteases. EMBO J. 24, 464-472.<br />
Friedmann, E., Lemberg, M.K., Weihofen, A., Dev, K.K., Dengler, U., et al. (2004) Consensus<br />
analysis of signal peptide peptidase and homologous human aspartic proteases reveals<br />
opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279, 50790-<br />
50798.<br />
Lemberg, M.K., and Martoglio, B. (2004) On the mechanism of SPP-catalysed intramembrane<br />
proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane.<br />
FEBS Lett. 564, 213-218. Review.<br />
Bland, F.A., Lemberg, M.K., McMichael, A., Martoglio, B., and Braud, V.M.<br />
(2003) Requirement of the proteasome for the trimming of signal peptide-derived epitopes<br />
presented by the nonclassical MHC class I molecule HLA-E. J. Biol. Chem. 278, 16528-<br />
16533.<br />
Lemberg, M.K., and Martoglio, B. (2003) Analysis of polypeptides by SDS-PAGE alongside in<br />
vitro generated reference peptides. Anal. Biochem., 319, 327-331.<br />
Weihofen, A.*, Lemberg, M.K.*, Friedmann, E. Rueeger, H., Schmitz, A., Paganetti, P.,<br />
Rovelli, G., and Martoglio, B. (2003). Targeting Presenilin-type Aspartic Protease Signal<br />
Peptide Peptidase with γ-Secretase Inhibitors. J. Biol. Chem. 278, 16528-16533. (* equally<br />
contributed)<br />
Lemberg, M.K., and Martoglio, B. (2002). Requirements for signal peptide peptidasecatalyzed<br />
intramembrane proteolysis. Mol. Cell 10, 735-744. Highlighted by Molecular Cell<br />
Preview; recommended by the Faculty of 1000.<br />
McLauchlan, J., Lemberg, M.K., Hope, G., and Martoglio, B. (2002). Intramembrane<br />
proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 21,<br />
3980-3988.<br />
Weihofen, A., Binns, K., Lemberg, M.K., Ashman, K., and Martoglio, B. (2002). Identification<br />
of signal peptide peptidase, a presenilin-type aspartic protease. Science 296, 2215-2218.<br />
Highlighted by Science Perspective; recommended by the Faculty of 1000.<br />
Lemberg, M.K*., Bland, F.A.*, Weihofen, A., Braud, V.M., and Martoglio, B. (2001).<br />
Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E<br />
epitopes. J. Immunol. 167, 6441-6446. (* equally contributed) Recommended by the Faculty<br />
of 1000.<br />
Weihofen, A., Lemberg, M.K., Ploegh, H.L., Bogyo, M., and Martoglio, B. (2000). Release of<br />
signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a<br />
protease activity that is specifically blocked by a novel cysteine protease inhibitor. J. Biol.<br />
Chem. 275, 30951-30956.<br />
CV Marius Lemberg page 2