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cv_lember_marius (PDF / 162.8 KB) - CellNetworks

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Dr. Marius Kaspar Lemberg<br />

Date of birth 23.11.1973 in Stuttgart<br />

Scientific Education<br />

Zentrum für Molekulare Biologie der Universität<br />

Heidelberg (ZMBH)<br />

Im Neuenheimer Feld 282<br />

69120 Heidelberg<br />

Germany<br />

Phone: +49-6221-545889; Fax: +49-6221-545893<br />

E-mail: m.<strong>lember</strong>g@zmbh.uni-heidelberg.de<br />

Web page: http://www.zmbh.uni-heidelberg.de/<strong>lember</strong>g/<br />

1997 Undergraduate degree in Biochemistry,<br />

Eberhard-Karls University Tübingen<br />

2000 Diploma of Natural Sciences,<br />

ETH Zürich, Switzerland.<br />

Topic of diploma thesis: Processing of signal peptides in<br />

rough microsomes<br />

2003 Doctor of Natural Sciences, Institute of Biochemistry,<br />

ETH Zürich, Switzerland.<br />

Topic: Intramembrane Proteolysis by the aspartic protease<br />

SPP<br />

2004 - 2007 Postdoctoral fellow with Dr. Matthew Freeman,<br />

MRC Laboratory of Molecular Biology, Cambridge, UK.<br />

Topics: Molecular mechanism of rhomboid-catalysed<br />

proteolysis; Characterization of mammalian rhomboids<br />

2007 - present Junior Group Leader at the ZMBH, University of Heidelberg<br />

Fellowships/Awards<br />

Personal PhD-student fellowship from the Boehringer Ingelheim Fonds (2001)<br />

EMBO long-term fellowship (2003)<br />

Award and Silver Medal for a distinguished PhD thesis, ETH Zürich (2004)<br />

SNF Fellowship for Advanced Researchers (2005)<br />

Filed of current interest<br />

Cell biology and membrane biology; mechanism, regulation and function of proteases; cellular<br />

quality control and cellular stress response<br />

Publications (5 most important are highlighted in bold)<br />

Fleig L., Bergbold N., Sahasrabudhe P., Geiger B., Kaltak L., and Lemberg M.K. (2012)<br />

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of<br />

Membrane Proteins. Mol. Cell 47, 558-569. Highlighted by News and Views in Nat. Struct.<br />

Mol. Biol., Preview in Dev. Cell and Faculty of 1000<br />

Prod´home V., Tomasec P., Cunningham C., Lemberg M.K., Stanton R.J., et al. (2012)<br />

Human Cytomegalovirus UL40 Signal Sequence Regulates Cell Surface Expression of the<br />

Natural Killer Cell Ligands HLA-E and gpUL18. J. Immunol. 188, 2794-2804.<br />

CV Marius Lemberg page 1


Lemberg, M.K. (2011) Intramembrane proteolysis in regulated protein trafficking. Traffic. 12,<br />

1109-1118. Review.<br />

Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M.K., and Freeman, M. (2011)<br />

Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12,<br />

421-427.<br />

Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D.J., and Lemberg, M.K. (2011) The<br />

mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1<br />

trafficking. J. Neurochem. 117, 856-867.<br />

Lemberg, M.K., and Freeman, M. (2007). Functional and evolutionary implications of<br />

enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17,<br />

1634-1646.<br />

Lemberg, M.K., and Freeman, M. (2007). Cutting proteins within lipid bilayers: rhomboid<br />

structure and mechanism. Mol. Cell. 28, 930-940. Review.<br />

Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M., and Freeman, M. (2005).<br />

Mechanism of intramembrane proteolysis investigated with purified rhomboid<br />

proteases. EMBO J. 24, 464-472.<br />

Friedmann, E., Lemberg, M.K., Weihofen, A., Dev, K.K., Dengler, U., et al. (2004) Consensus<br />

analysis of signal peptide peptidase and homologous human aspartic proteases reveals<br />

opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279, 50790-<br />

50798.<br />

Lemberg, M.K., and Martoglio, B. (2004) On the mechanism of SPP-catalysed intramembrane<br />

proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane.<br />

FEBS Lett. 564, 213-218. Review.<br />

Bland, F.A., Lemberg, M.K., McMichael, A., Martoglio, B., and Braud, V.M.<br />

(2003) Requirement of the proteasome for the trimming of signal peptide-derived epitopes<br />

presented by the nonclassical MHC class I molecule HLA-E. J. Biol. Chem. 278, 16528-<br />

16533.<br />

Lemberg, M.K., and Martoglio, B. (2003) Analysis of polypeptides by SDS-PAGE alongside in<br />

vitro generated reference peptides. Anal. Biochem., 319, 327-331.<br />

Weihofen, A.*, Lemberg, M.K.*, Friedmann, E. Rueeger, H., Schmitz, A., Paganetti, P.,<br />

Rovelli, G., and Martoglio, B. (2003). Targeting Presenilin-type Aspartic Protease Signal<br />

Peptide Peptidase with γ-Secretase Inhibitors. J. Biol. Chem. 278, 16528-16533. (* equally<br />

contributed)<br />

Lemberg, M.K., and Martoglio, B. (2002). Requirements for signal peptide peptidasecatalyzed<br />

intramembrane proteolysis. Mol. Cell 10, 735-744. Highlighted by Molecular Cell<br />

Preview; recommended by the Faculty of 1000.<br />

McLauchlan, J., Lemberg, M.K., Hope, G., and Martoglio, B. (2002). Intramembrane<br />

proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 21,<br />

3980-3988.<br />

Weihofen, A., Binns, K., Lemberg, M.K., Ashman, K., and Martoglio, B. (2002). Identification<br />

of signal peptide peptidase, a presenilin-type aspartic protease. Science 296, 2215-2218.<br />

Highlighted by Science Perspective; recommended by the Faculty of 1000.<br />

Lemberg, M.K*., Bland, F.A.*, Weihofen, A., Braud, V.M., and Martoglio, B. (2001).<br />

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E<br />

epitopes. J. Immunol. 167, 6441-6446. (* equally contributed) Recommended by the Faculty<br />

of 1000.<br />

Weihofen, A., Lemberg, M.K., Ploegh, H.L., Bogyo, M., and Martoglio, B. (2000). Release of<br />

signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a<br />

protease activity that is specifically blocked by a novel cysteine protease inhibitor. J. Biol.<br />

Chem. 275, 30951-30956.<br />

CV Marius Lemberg page 2

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