cv_lember_marius (PDF / 162.8 KB) - CellNetworks

cv_lember_marius (PDF / 162.8 KB) - CellNetworks

Dr. Marius Kaspar Lemberg

Date of birth 23.11.1973 in Stuttgart

Scientific Education

Zentrum für Molekulare Biologie der Universität

Heidelberg (ZMBH)

Im Neuenheimer Feld 282

69120 Heidelberg


Phone: +49-6221-545889; Fax: +49-6221-545893


Web page:

1997 Undergraduate degree in Biochemistry,

Eberhard-Karls University Tübingen

2000 Diploma of Natural Sciences,

ETH Zürich, Switzerland.

Topic of diploma thesis: Processing of signal peptides in

rough microsomes

2003 Doctor of Natural Sciences, Institute of Biochemistry,

ETH Zürich, Switzerland.

Topic: Intramembrane Proteolysis by the aspartic protease


2004 - 2007 Postdoctoral fellow with Dr. Matthew Freeman,

MRC Laboratory of Molecular Biology, Cambridge, UK.

Topics: Molecular mechanism of rhomboid-catalysed

proteolysis; Characterization of mammalian rhomboids

2007 - present Junior Group Leader at the ZMBH, University of Heidelberg


Personal PhD-student fellowship from the Boehringer Ingelheim Fonds (2001)

EMBO long-term fellowship (2003)

Award and Silver Medal for a distinguished PhD thesis, ETH Zürich (2004)

SNF Fellowship for Advanced Researchers (2005)

Filed of current interest

Cell biology and membrane biology; mechanism, regulation and function of proteases; cellular

quality control and cellular stress response

Publications (5 most important are highlighted in bold)

Fleig L., Bergbold N., Sahasrabudhe P., Geiger B., Kaltak L., and Lemberg M.K. (2012)

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of

Membrane Proteins. Mol. Cell 47, 558-569. Highlighted by News and Views in Nat. Struct.

Mol. Biol., Preview in Dev. Cell and Faculty of 1000

Prod´home V., Tomasec P., Cunningham C., Lemberg M.K., Stanton R.J., et al. (2012)

Human Cytomegalovirus UL40 Signal Sequence Regulates Cell Surface Expression of the

Natural Killer Cell Ligands HLA-E and gpUL18. J. Immunol. 188, 2794-2804.

CV Marius Lemberg page 1

Lemberg, M.K. (2011) Intramembrane proteolysis in regulated protein trafficking. Traffic. 12,

1109-1118. Review.

Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M.K., and Freeman, M. (2011)

Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12,


Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D.J., and Lemberg, M.K. (2011) The

mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1

trafficking. J. Neurochem. 117, 856-867.

Lemberg, M.K., and Freeman, M. (2007). Functional and evolutionary implications of

enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17,


Lemberg, M.K., and Freeman, M. (2007). Cutting proteins within lipid bilayers: rhomboid

structure and mechanism. Mol. Cell. 28, 930-940. Review.

Lemberg, M.K., Menendez, J., Misik, A., Garcia, M., Koth, C.M., and Freeman, M. (2005).

Mechanism of intramembrane proteolysis investigated with purified rhomboid

proteases. EMBO J. 24, 464-472.

Friedmann, E., Lemberg, M.K., Weihofen, A., Dev, K.K., Dengler, U., et al. (2004) Consensus

analysis of signal peptide peptidase and homologous human aspartic proteases reveals

opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279, 50790-


Lemberg, M.K., and Martoglio, B. (2004) On the mechanism of SPP-catalysed intramembrane

proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane.

FEBS Lett. 564, 213-218. Review.

Bland, F.A., Lemberg, M.K., McMichael, A., Martoglio, B., and Braud, V.M.

(2003) Requirement of the proteasome for the trimming of signal peptide-derived epitopes

presented by the nonclassical MHC class I molecule HLA-E. J. Biol. Chem. 278, 16528-


Lemberg, M.K., and Martoglio, B. (2003) Analysis of polypeptides by SDS-PAGE alongside in

vitro generated reference peptides. Anal. Biochem., 319, 327-331.

Weihofen, A.*, Lemberg, M.K.*, Friedmann, E. Rueeger, H., Schmitz, A., Paganetti, P.,

Rovelli, G., and Martoglio, B. (2003). Targeting Presenilin-type Aspartic Protease Signal

Peptide Peptidase with γ-Secretase Inhibitors. J. Biol. Chem. 278, 16528-16533. (* equally


Lemberg, M.K., and Martoglio, B. (2002). Requirements for signal peptide peptidasecatalyzed

intramembrane proteolysis. Mol. Cell 10, 735-744. Highlighted by Molecular Cell

Preview; recommended by the Faculty of 1000.

McLauchlan, J., Lemberg, M.K., Hope, G., and Martoglio, B. (2002). Intramembrane

proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 21,


Weihofen, A., Binns, K., Lemberg, M.K., Ashman, K., and Martoglio, B. (2002). Identification

of signal peptide peptidase, a presenilin-type aspartic protease. Science 296, 2215-2218.

Highlighted by Science Perspective; recommended by the Faculty of 1000.

Lemberg, M.K*., Bland, F.A.*, Weihofen, A., Braud, V.M., and Martoglio, B. (2001).

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E

epitopes. J. Immunol. 167, 6441-6446. (* equally contributed) Recommended by the Faculty

of 1000.

Weihofen, A., Lemberg, M.K., Ploegh, H.L., Bogyo, M., and Martoglio, B. (2000). Release of

signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a

protease activity that is specifically blocked by a novel cysteine protease inhibitor. J. Biol.

Chem. 275, 30951-30956.

CV Marius Lemberg page 2

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