Patologías digestivas

fcm.uncu.edu.ar

Patologías digestivas

Samuel Alexander Kinnier Wilson in 1912Enfermos 1:5000 / 1:30.000Portadores 1:90Consanguinidad58% India mutaciones cromosomicasATPB7Requerimiento dieta: 1-2 mg/dIn 1993, Wilson disease gene, ATP7B, was identified by separate groups.ATP7B encodes a metal-transporting P-type adenosine triphosphatase(ATPase), which is expressed mainly in hepatocytes and functions in theexcretion of copper into bile probably via the late endosome and lysosome.Failure of this system results in copper accumulation in the body.

More magazines by this user
Similar magazines