Réponses immunitaires et progression tumorale I) Inflammation ...
Réponses immunitaires et progression tumorale I) Inflammation ...
Réponses immunitaires et progression tumorale I) Inflammation ...
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T<br />
Tumor An4gènes antigens de tumeur recognized reconnus by par cytolytic des CTLs-‐classifica4on<br />
T lymphocytes<br />
Cancer<br />
germline<br />
many tumors<br />
male germinal cells<br />
other normal cells<br />
MAGE-A,B,C<br />
BAGE<br />
GAGE<br />
LAGE-1/NY-ESO-1<br />
HAGE<br />
SAGE<br />
SCP-1<br />
SSX<br />
Differentiation<br />
tumor of defined<br />
histological type<br />
normal tissue of same<br />
histological type<br />
other normal cells<br />
Tyrosinase<br />
Melan-A (MART-1)<br />
gp100 (Pmel17)<br />
gp75 (TRP-1)<br />
TRP-2<br />
CEA<br />
PSA<br />
kallikrein<br />
proteinase 3<br />
Mutation<br />
tumor<br />
normal cells<br />
MUM-1,2,3<br />
CDK4<br />
b<strong>et</strong>a-catenin<br />
HLA-A2<br />
CASP-8<br />
ras<br />
B-raf<br />
BCR-ABL<br />
...<br />
p53<br />
idiotype<br />
Overexpression<br />
Many tumors<br />
Oncovirus<br />
virus-induced tumors<br />
normal cells normal cells<br />
PRAME<br />
HER2/neu<br />
p53<br />
hTERT Télomérase<br />
survivin survivine<br />
wt1<br />
HPV-16<br />
EBV<br />
HTLV-1<br />
SV40<br />
Other<br />
MUC-1<br />
NA-17
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