lotegra (desloratadini) Semadgenloba: garsiT dafaruli erTi tableti ...

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lotegra (desloratadini) Semadgenloba: garsiT dafaruli erTi tableti ...

lotegra(desloratadini)Semadgenloba:garsiT dafaruli erTi tableti Seicavs:aqtiuri nivTiereba: desloratadini – 5 mg.damxmare nivTierebebi: laqtoza, magniumis oqsidi, mikrokristaluri celuloza, polieTilenglikoli,Jelatinizirebuli saxamebeli, titanis dioqsidi, TuTiis stearatiFD & C Blue #2 aluminium lake, hipromeloza,4000 CR.aTq kodi: R06AX27.farmakoTerapiuli jgufi:antihistaminuri preparatebi sistemuri gamoyenebisaTvis.H1-histaminuri receptorebis blokatori.farmakodinamika:lotegras gaaCnia antihistaminuri, antialergiuli da anTebis sawinaaR-mdego moqmedeba.igi warmoadgens H1- histaminuri receptorebis blokators, romelic ar avlens sedaciur moqmedebas.peroraluri miRebisas desloratadini (loratadinis pirveladi aqtiuri metaboliti)avlens periferiuli histaminuri H1-receptorebis SerCeviT blokirebas. igi Trgunavs citostatikurreaqciaTa kaskads: anTebis sawinaaRmdego citokinebis gamoyofas, maT Soris interleikin-4-is, interleikin-6-is, interleikin-8-is, interleikin-13-is, RANTES tipisanTebis sawinaaRmdego hemokinebis gamoyofas, aseve Trgunavs superoqsiduri anionebis produqciasaqtivirebuli polimorfulbirTvuli neirofilebiT, Trgunavs eozinofilebisadgeziasa da hemotaqsiss, adgeziis molekulaTa eqspresias, maT Soris R-seleqtinis, lgESualeduri histaminisda D2 prostaglandinisa da C4 leikotrienis gamoyofas.farmakokinetika:preparats axasiaTebs kargi absorbcia kuW-nawlavis traqtidan. plazmaSi maqsimaluri koncentracia miiRwevadaaxloebiT 3 saaTSi. naxevargamoy-ofis periodi daaxloebiT 27 saaTs Seadgens. bioSeRwevadoba miRebulidozis proporciulia (dozis diapazoni meryeobs 5 mg-dan20 mg-mde). igi ar gadis hematoencefalur bariers da praqtikulad ar metabolizdeba RviZlSi. aRwevsplacentarul bariers da gadadis dedis rZeSi.gamoyenebis Cveneba:- sezonuri polinozi da qronikuli alergiuli riniti- alergiuli koniunqtiviti (ceminebis, cxviridan gamonadenis, cxviris dacobis da qavilis, cremldenis,Tvalebis qavilis da hiperemiis moxsnis an Semsubuqebis mizniT)- qaviliT mimdinare dermatozebi- qronikuli idiopaTuri WinWris cieba (kanis qavilis da gamonayaris Semcirebisa da gaqrobis mizniT)dozirebis reJimi:lotegra iniSneba peroralurad 5 mg erTxel dReSi, kvebisgan damoukideblad. tableti gadaylapeT mTlianad,dauReWavad, daayoleT wyali.gverdiTi movlenebi:SesaZloa Tavis tkivili.iSviaTad piris simSrale, sisuste.ukuCveneba:orsuloba, laqtacia, momatebuli mgrZnobeloba desloratadinis mimarT.urTierTqmedeba sxva samkurnalo saSualebebTan:kvlevam aCvena, rom desloratadinis ketokonazolTan da eriTromicinTan erTad miReba klinikuradmniSvnelovan cvlilebebs ar iwvevs.sakvebTan erTad miReba organizmSi desloratadinis ganawilebaze gavlenas ar axdens.desloratadini ar aZlierebs alkoholis moqmedebas centralur nervul sistemaze.gansakuTrebuli miTiTeba:preparati sifrTxiliT gamoiyeneba Tirkmlis ukmarobis mwvave formis dros.gamoyeneba pediatriaSi:SesaZlebelia eqimis daniSnulebis Sesabamisad.avtomobilisa da sxva meqanizmebis marTvis unarze gavlena.desloratadini ar moqmedebs avtomobilis marTvisa da iseT samuSaoTa Sesrulebis unarze, romelicmoiTxovs swraf fsiqomotorul reaqcias.gamoSvebis forma:tableti 5 mg, SefuTvaSi garsiT dafaruli 10 tableti blisterze.1 blisteri gamoyenebis instruqciasTan erTad moTavsebulia muyaos kolofSi.Senaxvis pirobebi:SeinaxeT bavSvebisaTvis miuwvdomel adgilas, 25 0 C-mde temperaturis pirobebSi.vargisianobis vada :preparatis vargisianobis vadaa 2 weli warmoebis TariRidan.ar gamoiyenoT vargisobis vadis gasvlis Semdeg.afTiaqidan gacemis piroba:farmacevtuli produqtis jgufi III (gaicema receptis gareSe).


mwarmoebeli:`farmasaians~. ink (kanada)misamarTi: 6111, roialmaunTsuitis aveniu, monreali, kvebeki H4P 2T4.kanadawarmoebulia:ss ji-pi-si-s dakveTiTmisamarTi: 0108, sanapiros q #6. Tbilisi, saqarTve

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