Gen specie boala Faza de evolutie Infectiv /nu ... - Cursuri Medicina
Gen specie boala Faza de evolutie Infectiv /nu ... - Cursuri Medicina
Gen specie boala Faza de evolutie Infectiv /nu ... - Cursuri Medicina
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<strong>Gen</strong> <strong>specie</strong> <strong>boala</strong> <strong>Faza</strong> <strong>de</strong> <strong>evolutie</strong> <strong>Infectiv</strong><br />
/<strong>nu</strong><br />
Entamoeba hystolitica<br />
Dizenteria amibiana<br />
Negleria fowleri<br />
Meningoencefalita<br />
amibiana I acuta<br />
Acanthamoeba<br />
Giardia duo<strong>de</strong>nalis<br />
Giardioza<br />
-Chist: matur si imatur, <strong>nu</strong>cli<br />
in ochi <strong>de</strong> pasare, rezistent<br />
in mediu<br />
-Trofozoit : pseudopod<br />
unidirectional, forma<br />
vegetativa, <strong>nu</strong>cleu = roata<br />
cu spite<br />
-Chist: rotund, rezitent in<br />
mediu,<strong>nu</strong>cleu central in ochi<br />
<strong>de</strong> pasare<br />
-Flagelat: 2 flageli, la<br />
22(gra<strong>de</strong>) si umiditate <strong>nu</strong> se<br />
divi<strong>de</strong>, <strong>nu</strong> inchisteaza<br />
-Trofozoit: forma<br />
neregulata, pseudopod<br />
bilobat, citoplasma<br />
vacuolara, <strong>nu</strong>cleu in ochi <strong>de</strong><br />
pasare<br />
-Chist: rotund, rezistent,<br />
billamelar(exochist rotund si<br />
endochist pentagonal)<br />
-Trofozoit: f veg, mai multe<br />
pseudopo<strong>de</strong> mici =<br />
acanthopodi, <strong>nu</strong>cleu in ochi<br />
<strong>de</strong> pasare<br />
-chist-rezistenta: oval,<br />
perete gros bilamelar,<br />
2/4<strong>nu</strong>cleicorpi semilunari<br />
parabazali<br />
-trofozoit-vegetativ:<br />
piriform, 2 <strong>nu</strong>clei, disc<br />
a<strong>de</strong>ziv ventral-concava, 4<br />
perechi <strong>de</strong> flageli si 8 kineto<br />
<strong>nu</strong>clei<br />
!!!fara<br />
+<br />
+<br />
+<br />
+<br />
Transmitere Vector/gazda<br />
intmed/gazda<br />
<strong>de</strong>finitiva<br />
Digestiva Cec si colon<br />
Din apa – fose nazale – NV<br />
olfactiv - SNC<br />
-Conjuctiva oculara –<br />
<strong>de</strong>chistare – t – SNC<br />
Orga<strong>nu</strong>l afectat Diagnostic<br />
-ulceratii: nodular si<br />
serpiginos<br />
*morfologic id t – stadiu<br />
diareic & c – satadiu <strong>de</strong><br />
purtator<br />
*coproparazitologie –<br />
frotiu, coprocultura<br />
*biopsii <strong>de</strong> colon<br />
*imuno – copro ag<br />
Creier *morfologic: id t in LCR,<br />
in vivo/in vitro, inoculare<br />
la soarece, amprenta pe<br />
creier - necropsie<br />
Creier<br />
Lez ulcerative<br />
corneene + cheratite<br />
Irev - cecitate<br />
Digestiva Duo<strong>de</strong>n si IS 1/3<br />
proximal<br />
-asimptomatica la ad<br />
purtatori, acuta cu<br />
diaree exploziva si<br />
scuipat rectal si cronica<br />
abd cr dureros si SII<br />
-malabsorbtie<br />
*morfologic: id t in LCR,<br />
raclaj cornean – c+t ,<br />
in vivo/in vitro, inoculare<br />
la soarece<br />
*imuno – ag in LCR<br />
*ex coproparazitologic-<br />
pentru trofozoiti<br />
*EDS-absrotie lichid<br />
duo<strong>de</strong>nal/biopsie<br />
*enterotest<br />
*imuno-coproag<br />
! ac NU
Trichomonas vaginalis<br />
Trichomoniaza<br />
urogenitala<br />
Leishmania<br />
-tropica<br />
Buton <strong>de</strong> orient<br />
-major<br />
Buton <strong>de</strong> orient<br />
-mexicana mexicana<br />
Ulcer chicleros<br />
mitocondrimetabolism<br />
anaerob<br />
-amastigoti-cu corpi LD in<br />
MF<br />
-promastigoti- in vector<br />
-amastigoti-cu corpi LD in<br />
MF<br />
-promastigoti- in vector<br />
-amastigoti-cu corpi LD in<br />
MF<br />
-promastigoti- in vector<br />
-brasiliensis -amastigoti-cu corpi LD in<br />
MF<br />
-promastigoti- in vector<br />
-donovani<br />
Boala kalaazar(neagra)<br />
-amastigoti-cu corpi LD in<br />
MF<br />
-promastigoti- in vector<br />
Inoculativ-vectoriala<br />
Antroponotica<br />
Inoculativ-vectoriala<br />
zoonotica<br />
Inoculativ-vectoriala<br />
Inoculativ-vectoriala<br />
Inoculativ-vectoriala<br />
Phlebotom femela Piele:<br />
Buton <strong>de</strong> orient- forma<br />
uscata, vin<strong>de</strong>care lenta<br />
cu cicatrice mica<br />
Phlebotom femela Piele:<br />
Buton <strong>de</strong> orient- forma<br />
umeda, vin<strong>de</strong>care<br />
rapida cu cicatrice<br />
mare<br />
Phlebotom femela Muco-cutanat;<br />
Ulcer<br />
chiclerosulceratii pe<br />
cartilaje: nazal si pav<br />
urechii<br />
Phlebotom femela Muco-cutanat;<br />
Espundiaulceratie<br />
plus a<strong>de</strong>nopatie locala.<br />
In 2 4 ani poate ajunge<br />
la os<br />
Phlebotom femela Visceral;<br />
Dezvoltarea<br />
leptomonas in MF din<br />
SRE<br />
*id amastigoti pe biopsiela<br />
inoculare/amprente<br />
necroptice<br />
*id promastigoti pe med<br />
<strong>de</strong> cultura NNN<br />
*imuno ac si ag specifice<br />
*id amastigoti pe biopsiela<br />
inoculare/amprente<br />
necroptice<br />
*id promastigoti pe med<br />
<strong>de</strong> cultura NNN<br />
*imuno ac si ag specifice<br />
*id amastigoti pe biopsiela<br />
inoculare/amprente<br />
necroptice<br />
*id promastigoti pe med<br />
<strong>de</strong> cultura NNN<br />
*imuno ac si ag specifice<br />
*id amastigoti pe biopsiela<br />
inoculare/amprente<br />
necroptice<br />
*id promastigoti pe med<br />
<strong>de</strong> cultura NNN<br />
*imuno ac si ag specifice<br />
*id amastigoti pe biopsiela<br />
inoculare sau in ficatsplina/amprente<br />
necroptice
Trypanosoma<br />
-brucei gambiese<br />
Tripanosomiaza<br />
africana= <strong>boala</strong><br />
som<strong>nu</strong>lui vest si centru<br />
-brucei rho<strong>de</strong>siense<br />
Tripanosomiaza<br />
africana= <strong>boala</strong><br />
som<strong>nu</strong>lui est si sud<br />
-cruzi<br />
Tripanosomiaza<br />
americana= <strong>boala</strong><br />
Chagas<br />
-amastigoti<br />
-promastigoti<br />
-epimastigiti<br />
-trypomastogoti slen<strong>de</strong>r<br />
produce <strong>boala</strong> si se<br />
multiplica!!! Dar stumpy<br />
este esential pentru<br />
transmitere la vector<br />
!!!sferomastigotii trec<br />
bariera hematoencefalica<br />
-amastigoti<br />
-promastigoti<br />
-epimastigiti<br />
-trypomastogoti -slen<strong>de</strong>r<br />
produce <strong>boala</strong> si se<br />
multiplica!!! Dar stumpy<br />
este esential pentru<br />
transmitere la vector<br />
!!!sferomastigotii trec<br />
bariera hematoencefalica<br />
-amastigoti/pseudochist in<br />
tesuturi<br />
-trypomastogoti<br />
Toxoplasma gondii -tahizoit<br />
-bradizoit: -chist tisular<br />
-oochist – imatur,<br />
sporuleaza in 5 zile – matur<br />
(8 sporozoiti)<br />
+<br />
Inoculativvectorialatrypanom(ulce<br />
ratie pruriginoasa-cu<br />
cicatrice la vin<strong>de</strong>care)<br />
-Sem<strong>nu</strong>l winterottom<br />
-sem<strong>nu</strong>l<br />
keran<strong>de</strong>l=hiperestezii<br />
-evol lenta<br />
Inoculativvectorialatrypanom(ulce<br />
ratie pruriginoasa-cu<br />
cicatrice la vin<strong>de</strong>care)<br />
-Sem<strong>nu</strong>l winterottom<br />
-sem<strong>nu</strong>l<br />
keran<strong>de</strong>l=hiperestezii<br />
-evol rapida<br />
contaminativavectorialachagoma/Sem<br />
<strong>nu</strong>l romana-e<strong>de</strong>m<br />
palpebral unilateral—fv lla<br />
copii<br />
Digestiva<br />
Transplacentar<br />
Musca tze-tze-hematoga<br />
Musca tze-tze-hematoga<br />
Reduviid—hematofag,<br />
dar lasa <strong>de</strong>jectele, care<br />
sunt<br />
pruriginoaseconjuncti<br />
vita<br />
-sange-hemoflagelat<br />
polimorfi<br />
!!!poate suferi variatie<br />
antigenicaepuizare SI<br />
-febra neregulata si<br />
cefalee<br />
-modif ritm somn<br />
veghe<br />
-ob<strong>nu</strong>bilare coma<br />
<strong>de</strong>ces<br />
-sange-hemoflagelat<br />
polimorfi<br />
!!!poate suferi variatie<br />
antigenicaepuizare SI<br />
-febra neregulata si<br />
cefalee<br />
-modif ritm somn<br />
veghe<br />
-ob<strong>nu</strong>bilare coma<br />
<strong>de</strong>ces<br />
-f acuta cu fb, rash,<br />
miocardita.<br />
-f cronica<br />
megaorgnestica<br />
inervatia autonoma a<br />
m nete<strong>de</strong>/miocardice<br />
Creier<br />
Sit limfatic<br />
Boala abortiva si<br />
mafolmativa<br />
*id promastigoti pe med<br />
<strong>de</strong> cultura NNN<br />
*imuno ac si ag specifice<br />
*morf pe frotiu sau<br />
picatura groasa<br />
*biopsie ggl<br />
*IF<br />
*celula Mott pe necropsii<br />
cerebrale<br />
*morf pe frotiu sau<br />
picatura groasa<br />
*biopsie ggl<br />
*IF<br />
*celula Mott pe necropsii<br />
cerebrale<br />
*morf direct sau<br />
frotiutrypomastigoti<br />
monomorfi<br />
*necropsii ale<br />
pseudoochisturilor<br />
*xenodiagnostic<br />
*morfologic:<br />
-t p pe biopsi sre/la/lcr;<br />
frotiu; inocul la animal<br />
-b/ct necropsi musculare<br />
sau cerebrale<br />
*imuno<br />
*imag
Pneumocistis carinii -trofozoit<br />
Cryptosporidium<br />
parvum<br />
Isospora belli<br />
Plasmodium<br />
-falciparum<br />
Inoculativ-vectoriala<br />
-ovale Inoculativ-vectoriala<br />
-malariae<br />
Inoculativ-vectoriala<br />
-vivax Inoculativ-vectoriala<br />
Taenia solium -ou cu embrion<br />
+ Digestiva<br />
Teniaza <strong>de</strong> porc hexacant=infectioase<br />
Autoinfectie exogena si<br />
CISTICERCOZA -larva=cysticerc cellulosae + endogena<br />
-adult-scolex globulos cu 4<br />
ventuze si cu 20 carlige pe<br />
Heteroinfectie<br />
GI acci<strong>de</strong>ntala =om<br />
CISTICERCOZA(daca<br />
ouale ajung in<br />
stomaccysticercul va<br />
ajunge tisular)<br />
Plamani – fagure <strong>de</strong><br />
miere<br />
IS<br />
Cerebral<br />
Ocular<br />
Subcutan<br />
* morf-ex<br />
coproparazitologic pentru<br />
evid oua(microscopic) sau<br />
proglot (macroscopic)!ZN-<br />
*AMPRENTA ANALA
Taenia saginata<br />
Teniaza <strong>de</strong> vita<br />
Echinococcus<br />
gra<strong>nu</strong>losus<br />
Hidatoza chistica<br />
alveolari/multilocularis<br />
Hidatoza alveolara<br />
Diphyllobotrium latum<br />
Botriocefaloza<br />
Fasciola hepatica<br />
rostru<br />
-90% in ficat *imagistic: rmn, ct, rx,<br />
echo abd,<br />
*morf-piesa operatorie<br />
(CH cu vezicule fiice)<br />
*imuno ag+ac spec<br />
!!!consuma acid<br />
folic&vitB12 competitiv<br />
cu IS anemie<br />
megaloblastica,<br />
parestezii<br />
*morf-ex<br />
coproparazitologic pentru<br />
evid oua(microscopic) sau<br />
proglot (macroscopic)<br />
*
Paragonimus<br />
Schisostoma<br />
japonicum<br />
Enterobius<br />
vermicularis<br />
Oxiuroza<br />
Trichinella spiralis<br />
Trichineloza<br />
Ascaris lumbricoi<strong>de</strong>s<br />
Ascaridioza<br />
-ou: rezistent in ext<br />
-adult—buton cefalic <strong>de</strong><br />
fixare<br />
F-<br />
M-<br />
-larva:<br />
-adult<br />
F-vivipara<br />
M-spicul terminal in carja<br />
-ou: -fertil=<br />
fecundat,rezistent in sol,<br />
embr unicel<br />
-nefertil=<br />
nefecundat,oval cu go<strong>de</strong>uri<br />
si peret subtire,are o masa<br />
amorfa si <strong>nu</strong> poate<br />
embriona in sol<br />
-larva<br />
-adult<br />
F-gros cu capete drpte si<br />
mai lung<br />
M-subtire cu spicul terminal<br />
-<br />
+<br />
+ Digestiv<br />
auto/heteroinfectie<br />
Retroinfectie<br />
+ Digestiv AUTOXENE<br />
ZOONOZA-porc<br />
Ceculceratii ce se<br />
suprainfecteaza<br />
Prurit anogenital(<strong>de</strong> la<br />
<strong>de</strong>punerea <strong>de</strong> oua)<br />
-<strong>Faza</strong> intestinala cu<br />
enterita acuta<br />
-<strong>Faza</strong> <strong>de</strong> localizare:<br />
Chist muscular= larvaface<br />
o spira 2+ 1/2 in<br />
celula doica/fost miocit<br />
Digestiv -intestinali<br />
-abcese<br />
extraintestinale<br />
*morf: AMPRENTA ANALA<br />
pt femela si ou<br />
*rectosigmoidoscopie<br />
*an uzuale-anemie<br />
carentiala<br />
*r <strong>de</strong> ppdaca precipita<br />
viermii, atunci avem ac in<br />
ser<br />
*morf: biopsii musculare,<br />
necropsii<br />
*xenodg---tardiv/<br />
postmortem pt certitudine<br />
*emg pt stadilizare<br />
*morf M-adultii<br />
*morf m-oufetil/nefertilex<br />
coproparazitologic<br />
*rx cu BaSO4
Trichuris trichura<br />
Trichuriaza<br />
Ancylostoma<br />
duo<strong>de</strong>nale<br />
Ancylostomiaza<br />
Necator america<strong>nu</strong>s<br />
Necatoroza<br />
Wuchereria bancrofti<br />
Brugia malayi<br />
incurbat, e mai scurt<br />
-ou: rezistent in sol, forma<br />
<strong>de</strong> lamaie, dopuri hialine<br />
polare, masa vitelina<br />
amorfa<br />
-adult !!!400f/1m<br />
!vierme in bici=3/5 ant e<br />
subtire pt fixare<br />
-ou-neembrionat, morula cu<br />
2-4 blastomere<br />
-larva rabditoidaneinfesofag<br />
bicameral<br />
-larva strongyloidainfectioasa,<br />
patrun<strong>de</strong> PRIN<br />
PIELE<br />
-adult: F si M. are 2 perechi<br />
<strong>de</strong> dinti<br />
-ou-neembrionat, morula cu<br />
8-16blastomere<br />
-larva rabditoidaneinfesofag<br />
bicameral<br />
-larva strongyloidainfectioasa,<br />
patrun<strong>de</strong> PRIN<br />
PIELE<br />
-adult: F si M. are 2 lame<br />
- Digestiva-vegetale !!!hematofag IS *rectosigmoidoscopie<br />
*morf m-ou-ex<br />
coproparazitologic<br />
-<br />
-<br />
+<br />
-<br />
-<br />
+<br />
Patru<strong>de</strong>re prin pielea larvei<br />
Sau prin mucoasa digestiva<br />
Sau tranzit pulmonar<br />
!v cu carlig-z temperate<br />
Patru<strong>de</strong>re prin pielea larvei<br />
Sau prin mucoasa digestiva<br />
Sau tranzit pulmonar<br />
!v cu carlig-tropicale<br />
!!!hematofag Duo<strong>de</strong>n-jejun<br />
-faza larvara cu<br />
urticarie/ pneumonie<br />
-faza intestinala cu<br />
enterita acuta sau<br />
cronica<br />
!!!hematofag Duo<strong>de</strong>n-jejun<br />
Inoculativ-vectoriala -limfatic<br />
Inoculativ-vectoriala -limfatic<br />
*morf-ex copropar-ou si<br />
adulti<br />
*tubaj dd-adulti si ou<br />
*EDS<br />
*hemato-verificare<br />
anemiei
Onchocercus volvulus<br />
Loa loa<br />
Dracunculus<br />
medinensis<br />
Inoculativ-vectoriala -subcutan<br />
Inoculativ-vectoriala -subcutan<br />
Digestiv -subcutan
Cambia lingua