rocephin - GPC

“vamtkiceb”
saqarTvelos Sromis, jamrTelobisa da
socialuri dacvis ministri
----------------------------- a. gamyreliZe
“--------“ _______________ 2002w.
rocefini
gamoyenebis instruqcia
ÀÌÏÚÄÍÄÁÉÓ ÉÍÓÔÒÖØÝÉÀ
ROCEPHIN
generiuli dasaxeleba:
Ceftriaxone
qimiuri dasaxeleba:
dinatrium-(Z)-(6R,7R)-7-2 (2-amino-1.3-Tiazol-4-il)-2-(metoqsiimino)
acetamido)-8-oqso-3-(2.5-dihidro-2-meTil-6-oqsido-5-oqso-1,2,4-triazin-3il)
TiomeTil)-5-Tia-1-azabiciklo (4.2.0.)-oqt-2-en-2-karboqsilati.
rocefini warmoadgens TeTr an moyviTalo-narinjisferi Seferilobis
kristalur fxvnils.
Semadgenloba:
erTi flakoni mSrali fxvniliT kunTebSi saineqcio xsnaris dasamzadeblad
Seicavs:
aqtiuri nivTiereba:
ceftriaqsoni-0.25g; 0.5g; 1g.
(1 ampula 2ml an 3.5ml 1% lidokainis xsnarTan erTad.)
erTi flakoni mSrali fxvniliT venaSi Sesayvani saineqcio xsnaris
dasamzadeblad Seicavs:
aqtiuri nivTiereba:
ceftriaqsoni-0.25g; 0.5g; 1g.
(1 ampula 5ml an 10ml saineqcio wyalTan erTad.)
erTi flakoni mSrali fxvniliT kunTebSi, venaSi an sainfuzio xsnaris
dasamzadeblad Seicavs:
aqtiuri nivTiereba:
ceftriaqsoni 1g.
(gamxsnelis gareSe).
erTi flakoni mSrali fxvniliT venaSi Sesayvani wveTovani saineqcio
xsnaris dasamzadeblad Seicavs:
aqtiuri nivTiereba:
ceftriaqsoni-2g.

ocefinis yvela samkurnalo formebi 1g ceftriaqsonisTvis Seicavs
daaxloebiT 83mg (3.6mmol) natriumis marils.
forma:
fxvnili saineqcio xsnaris mosamzadeblad 0.25g; 0.5g; 1g.
farmakoTerapiuli jgufi:
cefalosporinebis jgufis antibiotiki
farmakologiuri Tvisebebi:
ceftriaqsoni warmoadgens prolongirebuli moqmedebis III generaciis
cefalosporinebis rigis antibiotiks parenteraluri gamoyenebisaTvis.
ceftriaqsonis baqteriociduli moqmedeba ganpirobebulia ujredis kedlis
sinTezis inhibirebiT. In vitro igi xels uSlis umravlesi gram-dadebiTi da
gram-uaryofiTi mikroorganizmebis zrdis process. igi mdgradia betalaqtamazebis
(umravlesi gram-uaryofiTi da gram-dadebiTi baqteriebis mier
producirebuli, rogorc penicilinazas, agreTve cefalosporinazas)
mimarT.
In vitro da klinikuri praqtikis pirobebSi ceftriaqsoni aqtiuria Semdegi
mikroorganizmebis mimarT:
gram-dadebiTi aerobebi:
Staphylococcus aureus (meticilinis mimarT mdgradi), koagulazo-uaryofiTi
stafilokokebi, Streptococcus pyogenes (β-hemolizuri, A jgufis),
Streptococcus agalactiae ((β-hemolizuri, B jgufis), β-hemolizuri
streptokokebi (arc A da arc B jgufis), Streptococcus viridans, Streptococcus
pneumoniae.
SeniSvna: meticilinis mimarT mdgradi Staphylococcus spp., rezistentulia
agreTve cefalosporinebis, maT Soris, ceftriaqsonis mimarT.
rogorc wesi, enterokokebis umravlesi Stamebi mag. Enterococcus faecalis,
Enterococcus faecium da Listeria monocytogenes mdgradia agreTve
ceftriaqsonis mimarT.
gram-uaryofiTi aerobebi:
Acinetobacter lwoffi, Acinetobacter anitratus ( ZiriTadad, A. baumanii), Aeromonas
Hydrophila, Alcaligenes faecalis, Alcaligenes odorans, alkaligenomsgavsi
baqteriebi, Borrelia burgdorferi, Capnocytophaga spp., Citrobacter diversus (maT
Soris, C. amalonaticus), Citrobacter freundii, Escherichia coli, Enterobacter
aerogenes, Enterobacter cloacae, Enterobacter spp. (zogierTi), Haemophylus
ducreyi, Haemophylus influenzae, Haemophylus parainfluenzae, Hafnia alvei,
Klebsiella oxytoca, klebsiella pneumoniae, Moraxella catarrhalis (adre Branhamella
catarralis wodebuli), Moraxella osloensis, Moraxella spp., (zogierTi), Moraxella
morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida,
Plesiomonas shigelloides, proteus mirabiles, Proteus penneri, Proteus vulgaris,
Pseudomonas fluorescens, Pseudomonas spp., (zogierTi), Providentia rettgeri,
Providentia spp., (zogierTi), Salmonella typhi, Salmonella spp. (nefitoiduri),

Serratia marcescens, Serratia spp. (zogierTi), Shigella spp., Vibrio spp., Yersinia
enterocolitica, Yersinia spp. (zogierTi).
SeniSvna:
CamoTvlili mikroorganizmebis zogierTi izolatebi, romlebic
gamoimuSaveben beta-laqtamazas, mdgradni arian ceftriaqsonis mimarT.
SeniSvna:
zemoT CamoTvlili mikroorganizmebis zogierTi Stamebi,
naxevradrezistentulni arian sxva antibiotikebis mimarT, rogoricaa,
aminopenicilinebi da ureidopenicilinebi, ceftriaqsonis mimarT
mgrZnobiare I da II Taobis cefalosporinebi da aminoglikozidebi.
Treponema pallidum mgrZnobiarea ceftriaqsonis mimarT, rogorc In vitro,
agreTve cxovelebze Catarebuli cdebis Sedegad. pirveladi da meoradi
aTaSangis SemTxvevaSi ceftriaqsoni xasiaTdeba kargi efeqtiT.
anaerobuli paTogenebi:
Bacteroides spp., (maT Soris B. fragilis zogierTi Stamebi), Clostridium spp.,
(garda C difficile), Fusobacterium nucleatum, Fusobacterium spp., Gaffkia
anaerobica (adre Peptococcus wodebuli), Peptostreptococcus spp.
CamoTvlili mikroorganizmebis zogierTi Stamebi beta-laqtamazas
warmoqmnis gamo mdgradni arian ceftriaqsonis mimarT.
SeniSvna: beta-laqtamazwarmomqmneli Bacteroides spp. mravali Stamebi
(kerZod B. fragilis ) mdgradni arian. mdgradia agreTve Clostridium difficile.
ceftriaqsonis mimarT mgrZnobelobis gansazRvris mizniT iyeneben klinikur
laboratoriuli standartebis nacionaluri komitetis mier mowodebul
diskodifuzur an agarze da bulionze seriuli ganzavebebis standartul
meTodebs. gansazRvrisaTvis iyeneben ceftriaqsonis Semcvel diskebs.
rogorc naCvenebia cxrilSi, In vitro klasikur cefalosporinebis mimarT
paTogenebis garkveuli Stamebi mdgradia.
ceftriaqsonis mimarT gamomwvevi Stamebis mgrZnobelobis testebi.
sinji ganzavebaze,
damTrgunveli
koncentracia mg\l
difuziis testi (30mkg
ceftriaqsonis Semcveli
diski) diametri mm-Si
mgrZnobiare
Stami
zomierad
mgrZnobiare
Stami
=8 16-32 =64
=21 20-14 =13
mdgradi Stami
farmakokinetika:
ceftriaqsonis saerTo koncentraciebze damokidebuli yvela ZiriTadi
farmakokinetikuri parametrebi, naxevrad gamoyofis periodis garda,
damokidebulia preparatis dozaze.
Sewova:

ceftriaqsonis maqsimaluri koncentracia sisxlis plazmaSi aRiniSneba 2-
3sT-is ganmavlobaSi 1g preparatis kunTebSi erTjeradi ineqciis Semdeg da
Seadgens daaxloebiT 81mg\l-s.
mrudi “koncentracia-dro”-s farTi sisxlis SratSi preparatis kunTebSi
da venaSi ineqciis dros erTnairia, rac metyvelebs imaze, rom
ceftriaqsonis bioSeRwevadoba misi kunTebSi ineqciebis dros Seadgens
100%-s.
ganawileba:
ceftriaqsonis moculobiTi ganawilebis koeficienti Seadgens 7-12l-s.
venaSi Seyvanis dros 1-2g ceftriaqsoni swrafad difundirebs qsovilebSi
da intersticiul siTxeebSi (maT Soris, filtvebSi, gulSi, sanaRvle
gzebSi, RviZlSi, nuSisebr jirkvlebSi, Sua yurSi da cxviris lorwovan
garsSi, ZvlebSi, agreTve Tavzurg-tvinis, plevralur da sinovialur
siTxeebSi da winamdebare jirkvlis sekretSi), sadac preparatis
baqteriociduli moqmedeba misadmi mgrZnobiare paTogenebis mimarT
SenarCunebulia 24sT-is ganmavlobaSi.
plazmis cilebTan kavSiri:
ceftriaqsoni Seqcevadad ukavSirdeba albuminebs da es kavSiri misi
koncentraciis ukuproporciulia: mag. im SemTxvevaSi, rodesac preparatis
koncentracia sisxlis SratSi ara umcires 100mg\l-ia, ceftriaqsonis
kavSiri cilebTan Seadgens 95%, xolo preparatis koncentraciisas
300mg\l-mxolod 85%-s.
intersticiul siTxeSi albuminis dabali Semcvelobis gamo ceftriaqsonis
koncentracia masSi ufro maRalia, vidre sisxlis SratSi.
preparatis SeRwevadoba Tavzurg-tvinis siTxeSi:
axalSobilebSi da bavSvebSi tvinis garsis anTebis dros ceftriaqsoni
aRwevs Tavzurg-tvinis siTxeSi.
baqteriuli meningitis dros sisxlis SratSi arsebuli preparatis
koncentraciis saSualod 17% difundirebs Tavzurg-tvinis siTxeSi, rac
daaxloebiT 4-jer ufro metia vidre aseptiuri meningitis dros.
ceftriaqsonis 50-100mg\kg wonaze doziT venaSi infuziidan 24sT-is Semdeg,
Tavzurg-tvinis siTxeSi preparatis koncentracia aRemateba 1.4mg\l-s.
meningitiT daavadebul mozrdilebSi ceftriaqsonis 50mg\kg wonaze doziT
Seyvanidan 2-2,5sT-is Semdeg ceftriaqsonis koncentracia mravaljer
aRemateba im minimalur dozas, romelic aucilebelia meningitis gamomwvevi
paTogenuri mikroorganizmebis dasaTrgunad.
ceftriaqsoni gaivlis placentur bariers da mcire koncentraciebSi
eqskregirebs dedis rZeSi.
metabolizmi:
ceftriaqsoni ar ganicdis sistemur metabolizms. nawlavuri floris
zemoqmedebiT igi gardaiqmneba araaqtiur metabolitad.
gamoyofa:
ceftriaqsonis saerTo plazmuri klirensi Seadgens 10-22ml\wT-Si.
Tirkmlis klirensi-5-12ml\wT-Si. ceftriaqsoni ucvleli saxiT (50%-mde),
xolo 40-50% Tirkmelebis saSualebiT, eliminirdeba naRvelTan erTad.
mozrdilebSi ceftriaqsonis naxevrad gamoyofis periodi Seadgens
daaxloebiT 8sT-s.

axalSobilebSi Seyvanili dozis daaxloebiT 70% gamoiyofa Tirkmelebis
saSualebiT.
axalSobilebSi 8 dRemde da 75 wlis asakis zemoT pacientebSi aRniSnuli
periodi orjer ufro xangrZlivia.
RviZlisa da Tirkmelebis ukmarisobis mqone mozrdil pacientebSi
ceftriaqsonis farmakokinetika TiTqmis ar icvleba, xolo eliminaciis
naxevarperiodi umniSvnelod xangrZlivdeba. Tirkmelebis funqciis
darRvevis SemTxvevaSi, preparatis gamoyofa Zlierdeba naRvelTan erTad,
xolo RviZlis paTologiebis dros piriqiT-Tirkmelebis saSualebiT.
Cveneba:
rocefinis mimarT mgrZnobiare paTogenuri mikroorganizmebiT gamowveuli
infeqciebi: sefsisi, meningiti, laimas diseminirebuli boreliozi
(daavadebis adreuli da gviani stadiebi), muclis Rrus organoebis
infeqciebi (peritoniti, kuW-nawlavis traqtis, sanaRvle gzebis
infeqciebi), Zvlebis, saxsrebis, SemaerTebeli qsovilis, kanis, WrilobiT
gamowveuli infeqciebi.
infeqciebi daqveiTebuli imunuri sistemis mqone pacientebSi. Tirkmelebisa
da saSarde gzebis infeqciebi, qveda sasunTqi gzebis (gansakuTrebiT
pnevmoniebi, bronqitebi) infeqciebi, otorinolaringologiuri infeqciebi,
genitaliumis infeqciebi, maT Soris gaurTulebeli gonorea da sxva
infeqciebi, romlebic gadaecema sqesobrivi gziT.
iyeneben agreTve qirurgiuli operaciebis Semdgom periodSi ganviTarebuli
infeqciebis profilaqtikisaTvis.
winaaRmdegCveneba:
momatebuli mgrZnobeloba cefalosporinebis rigis antibiotikebis mimarT;
gverdiTi movlenebi:
sistemuri gverdiTi efeqtebi: Civilebi kuW-nawlavis traqtis mxriv
(avadmyofTa daaxloebiT 2%-s): Txieri ganavali an diarea, gulisreva,
Rebineba, stomatiti da glositi.
cvlilebebi sisxlis suraTis mxriv (avadmyofTa daaxloebiT 2%-s):
eozinofilia, leikopenia, granulocitopenia, hemolizuri anemia,
Trombocitopenia. aRwerilia agranulocitozis erTeuli SemTxvevebi (1mkl-
Si 500 ujredze naklebi), maT Soris umetesi nawili warmoiqmneba
mkurnalobidan 10 dRis Semdeg da preparatis kumulaciur dozebSi 20mg da
meti raodenobiT miRebis dros.
kanis reaqciebi (avadmyofTa daaxloebiT 1%-s): gamonayari, alergiuli
dermatiti, urtikaria, SeSupeba. mZime SemTxvevebSi viTardeba
multiformuli eriTema, stivens-jonsonis sindromi, laielis sindromi an
toqsiuri epidermuli nekrolizi.
sxvadasxva iSviaTad: Tavis tkivili, Tavbrusxveva, RviZlis fermentebis
aqtivobis momateba, Sesabamisi simptomatikis mqone ceftriaqsonis
kalciumis marilebis precipitacia naRvlis buStSi, oliguria, sisxlis
SratSi kreatininis raodenobis gazrda, genitaliumis areSi-mikozebi,
temperaturis momateba, Semcivneba, anafilaqsia an anafilaqsiuri reaqciebi.

iSviaTad adgili aqvs fsevdomembranuli kolitis ganviTarebas da sisxlis
Sededebis darRvevas, agreTve TirkmelebSi konkrementebis warmoqmnas,
ZiriTadad 3 wlis asakis zemoT bavSvebSi, romlebic iReben preparats didi
sadReRamiso dozebiT (≥80mg\kg dReRameSi) an kumulaciuri dozebiT 10mg
da meti, agreTve sxva damatebiTi risk faqtorebis dros (siTxis miRebis
SezRudva, woliTi reJimi da sxva).
TirkmelebSi konkrementebis warmoqmnis procesi mimdinareobs usimptomod
an zogjer klinikurad vlindeba Tirkmelebis ukmarisobiT. aRniSnuli
procesi Seqcevadia rocefiniT mkurnalobis Sewyvetis SemTxvevaSi.
adgilobrivi gverdiTi efeqtebi (iSviaTad):
preparatis venaSi Seyvanis dros gamoricxuli ar aris flebitis
ganviTareba. aRniSnuli movlenis Tavidan acileba SesaZlebelia preparatis
neli (2-4wT-is ganmavlobaSi) SeyvaniT.
lidokainis damatebis gareSe ceftriaqsonis kunTebSi ineqciebi iwvevs
tkivils.
kunTebSi ineqcia lidokainis gamoyenebis gareSe mtkivneulia.
aRniSnuli gverdiTi efeqtebi ZiriTadad gaivlis spontanurad an
preparatiT mkurnalobis Sewyvetis Semdeg.
urTierTqmedeba sxva preparatebTan:
rocefinis didi dozebiT da Zlieri diurezuli saSualebebis (mag.
furosemidis) erTdrouli gamoyenebiT ar aRiniSneba Tirkmelebis funqciis
darRveva.
rocefini ar zrdis aminoglikozidebis nefrotoqsiurobas.
rocefinis Seyvanis Semdeg alkoholuri sasmelis miReba ar iwvevs
disulfiramis msgavsi reaqciebis warmoqmnas.
ceftriaqsoni ar Seicavs N-meTilTiotetrazolis jgufs, romelic iwvevs
eTanolis mimarT reaqcias da sisxldenas, riTac arsebiTad xasiaTdebian
zogierTi sxva cefalosporinebi.
probenecidi gavlenas ar axdens rocefinis organizmidan gamoyofis
procesze.
In vitro dadgenilia qloramfenikolsa da ceftriaqsons Soris antagonizmi.
SeuTavsebloba:
ceftriaqsonis xsnaris Sereva sxva sainfuzio xsnarebTan, romlebic
Seicavs kalciums mag. hartmanis da ringeris siTxeebTan an misi
erTdrouli Seyvana organizmSi sxva antibaqteriul preparatebTan
amsakrinTan, vankomicinTan, flukonazolTan da aminoglikozidebTan erTad
rekomendirebuli ar aris.
laboratoriul maCveneblebze zemoqmedeba:
rocefiniT mkurnalobis procesSi avadmyofebSi iSviaT SemTxvevebSi
adgili aqvs kumbsis sinjze crudadebiT maCveneblebs.
iseve rogorc sxva antibiotikebi, rocefini crudadebiT maCveneblebs
iZleva galaqtozemiis sinjze. aseTive maCveneblebi miiReba SardSi
glukozis gansazRvris dros, amitom rocefiniT mkurnalobis procesSi
glukozuriis gansazRvra aucileblobis SemTxvevaSi xdeba mxolod
fermentuli meTodiT.

sifrTxile:
anamnezis zusti monacemebis Segrovebis miuxedavad, rac aucileblobas
warmoadgens sxva cefalosporinebis rigis antibiotikebTan mimarTebaSi
SeiZleba gamoiricxos anafilaqsiuri Sokis ganviTarebis SesaZlebloba.
avadmyofebSi penicilinis mimarT momatebuli mgrZnobelobis dros saWiroa
gansakuTrebuli sifrTxile, SesaZlebeli jvaredini alergiuli reaqciebis
warmoqmnis Tavidan acilebis mizniT.
iseve rogorc sxva antibaqteriuli preparatebiT mkurnalobis dros,
SesaZlebelia superinfeqciebis ganviTareba.
ultrabgeriTi gamokvlevebis dros zogjer naRvlis buStSi aRiniSneba
Crdilis arseboba, rac miuTiTebs naleqebis dagrovebaze, romelic
warmoadgens ceftriaqsonis kalciumis marilis precipitatebs, aRniSnuli
movlenebi maleve gaivlis simptomaturi mkurnalobis, an ceftriaqsoniT
mkurnalobis droebiTi Sewyvetis Sedegad. tkivilis sindromis arsebobac
ki msgavs SemTxvevebSi ar saWiroebs qirurgiul Carevas, sakmarisia
konservatuli mkurnaloba.
zogierT avadmyofebSi rocefinis miRebis dros adgili aqvs sanaRvle
gzebis obstruqciiT gamowveul pankreatitis iSviaT SemTxvevebs.
dadgenilia, rom sxva cefalosporinebis rigis antibiotikebis msgavsad,
ceftriaqsoni aZevebs sisxlis SratTan SekavSirebul albumins, ris gamoc
hiperbilirubinemiiT Sepyrobil axalSobilebSi da gansakuTrebiT
dRenaklul bavSvebSi, romlebSic arsebobs bilirubiniT gamowveuli
encefalopaTiis ganviTarebisa riski, ceftriaqsonis gamoyeneba saWiroebs
gansakuTrebul sifrTxiles.
orsuloba da laqtacia:
ceftriaqsoni gaivlis placentur bariers.
preparatis gamoyenebis usafrTxoeba orsulobis dros dReisaTvis
dadgenili ar aris.
mcire koncentraciebSi ceftriaqsoni gadadis dedis rZeSi, amitom
laqtaciis periodSi misi gamoyenebis dros saWiroa gansakuTrebuli
sifrTxile.
miRebis wesi da dozireba:
ceftriaqsoni SehyavT kunTebSi an venaSi.
mozrdilebSi da 12 wlis asakis zemoT bavSvebSi ceftriaqsonis doza
Seadgens 1-2g-s 1-jer (yovel 24sT-Si).
mZime SemTxvevebSi an zomierad mgrZnobiare paTogenuri mikrobebiT
gamowveuli infeqciebis dros SesaZlebelia erTjeradi sadReRamiso dozis
gazrda 4g-mde.
axalSobilebSi 2 kviramde ceftriaqsonis dozaa-20-50mg\kg wonaze
dReRameSi. (axalSobilebSi fermentuli sistemis arasrulfasovnebis gamo
preparatis daniSvna 50mg\kg\wonaze ufro meti doziT nebadarTuli ar
aris).
bavSvebSi 2 Tvis asakidan 12 wlis asakamde sadReRamiso doza Seadgens 20-
80mg\kg wonaze.

50kg da meti wonis mqone bavSvebs preparati eniSnebaT igive dozebSi,
rogorc mozrdilebs.
preparatis venaSi infuzia grZeldeba 30wT-is ganmavlobaSi.
mkurnalobis xangrZlivoba damokidebulia paTologiuri procesis
mimdinareobaze da daavadebis simZimis xarisxze, agreTve mocemul
baqteriologiur gamokvlevebze. ZiriTadad igi Seadgens 4-14 dRes. mZime
infeqciuri daavadebebis dros, SesaZlebelia ufro xangrZlivi Terapia.
daavadebis simptomebis gaqrobis Semdeg, umravlesi infeqciuri daavadebebis
dros mkurnaloba grZeldeba minimum 48-72 sT-s.
kombinirebuli mkurnaloba:
dadgenilia, rom mraval gram-uaryofiT baqteriebze zemoqmedebiT
ceftriaqsonsa da aminoglikozidebs Soris adgili aqvs sinergizms, Tumca
msgavsi kombinaciis mapotencirebeli efeqtis winaswar gansazRvra
SeuZlebelia, mZime da sicocxlisaTvis saSiSi infeqciebis dros (mag.
Pseudomonas aeruginosa-s mier gamowveuli) gansakuTrebiT ki maTi
erTdrouli daniSvniT. ceftriaqsoni da aminoglikozidebi maTi
SeuTavseblobis gamo aucilebelia dainiSnos rekomendebul dozebSi calcalke.
meningiti:
axalSobilebSi da bavSvebSi baqteriuli meningitis dros preparatis
sawyisi doza Seadgens 100mg\kg wonaze 1-jer dReSi (maqsimaluri 4g-s).
mas Semdeg, rac SesaZlebelia paTogenuri mikroorganizmebis gamoyofa da
misi mgrZnobelobis gansazRvra, saWiroa dozis Sesabamisi Semcireba.
metad mnSvnelovani monacemebis miReba SeiZleba Sesabamis vadebSi
mkurnalobis Sedegad, romelic mocemulia qvemoT moyvanil cxrilSi.
daavadebis gamomwvevi mkurnalobis xangrZlivoba
Neisseria meningitidis 4 dRe
Haemophilus influenzae 6 dRe
Streptococcus pneumoniae 7 dRe
laimas boreliozi:
mozrdilebs da bavSvebs eniSnebaT 50mg\kg (umaRlesi sadReRamiso doza-2g)
1-jer dReRameSi 14 dRis ganmavlobaSi.
gonorea:
rogorc penicilinazas warmomqmneli, agreTve misi ar warmomqmneli
StamebiT gamowveuli gonoreis mkurnalobis rekomendebul dozas Seadgens
250mg 1-jer kunTebSi.
inficirebuli an savaraudod inficirebuli qirurgiuli Carevis win
infeqciis simZimis mixedviT-operaciamde 30-90wT-iT adre rekomendebulia
1-2g ceftriaqsonis erTjeradad Seyvana.
RviZlisa da Tirkmelebis funqciis ukmarisoba:
Tirkmelebis funqciis darRvevis mqone avadmyofebSi-RviZlis normaluri
funqcionirebis pirobebSi- aucilebeli ar aris ceftriaqsonis dozis
Semcireba. mxolod Tirkmelebis ukmarisobis dros preterminalur stadiaSi
(kreatininis klirensi naklebia 10ml\wT-Si), ceftriaqsonis sadReRamiso
doza ar unda aRematebodes 2g-s.

RviZlis funqciis darRvevis mqone avadmyofebSi-Tirkmelebis Senaxuli
funqciis SemTxvevaSi- aucilebeli ar aris ceftriaqsonis dozis Semcireba.
RviZlisa da Tirkmelebis erTdrouli mZime paTologiebis SemTxvevaSi
aucilebelia sisxlis SratSi ceftriaqsonis koncentraciis regularuli
kontroli.
hemodializze myof avadmyofebSi, aRniSnuli proceduris Catarebis Semdeg
preparatis dozis Secvla aucilebeli ar aris.
momzadebuli xsnari oTaxis temperaturaze inarCunebs Tavis fizikur da
qimiur stabilurobas 6sT-is ganmavlobaSi. 5 0 C temperaturaze-24sT-is
ganmavlobaSi. Tumca sayovelTaod miRebuli wesis Sesabamisad, saWiroa
axladmomzadebuli xsnaris dauyovnebliv Seyvana organizmSi.
momzadebuli xsnaris feri SeiZleba iyos Ria yviTelsa da ambris ferebs
Soris, rac damokidebulia preparatis koncentraciaze da misi Senaxvis
xangrZlivobaze.
aqtiuri nivTierebis xsnaris feri gavlenas ar axdens preparatis
samkurnalo efeqtze.
kunTebSi Seyvanis dros umtkivneulo ineqciebisaTvis preparatis 0.25g an
0.5g-s sxnian 2ml 1% lidokainis xsnarSi Semdegi TanafardobiT: flakonis
SigTavss 1g-s xsnian 3.5ml lidokainis xsnarSi da SehyavT Rrmad
dunduloSi. lidokainis Seyvana venaSi nebadarTuli ar aris.
venaSi Seyvanis dros preparatis 0.25g an 0.5g-s xsnian 5ml sterilur
saineqcio wyalSi Semdegi TanafardobiT: flakonis SigTavss 1g-s xsnian
10ml sterilur distilirebul wyalSi da SehyavT venaSi nela 2-4wT-is
ganmavlobaSi.
venaSi infuziis xangrZlivoba Seadgens 30wT-s. amisaTvis 2g fxvnils xsnian
daaxloebiT 40ml kalciumis ionisagan Tavisufal xsnarSi: mag. 0.9%
natriumis qloridis an 0.45% natriumis qloridis xsnarSi 2,5%
glukozis SemcvelobiT, 5% an 10% glukozis xsnarSi, 5% fruqtozis, 6%
deqstrozis xsnarSi. sxva gamxsnelebs ar iyeneben.
Warbi dozireba:
dozis gadaWarbebis dros hemodializi da peritonealuri dializi
araefeqturia.
specifiuri antidoti ar arsebobs.
mkurnaloba simptomaturia.
Senaxvis vada:
3 weli
Senaxvis pirobebi:
sinaTlisagan dacul adgilas, ara umetes 25 0 C temperaturaze.
bavSvebisagan dacul adgilas.
momzadebuli xsnari inaxeba oTaxis temperaturaze ra umetes 6sT-is
ganmavlobaSi an macivarSi 2-8 0 C temperaturaze ara umetes 24sT-is
ganmavlobaSi.

SefuTva:
1 flakoni mSrali fxvniliT, romelic Sesabamisad Seicavs 0.25g, 0.5g an 1g
ceftriaqsons da 1 ampula 2ml an 3.5ml 1%-iani lidokainis xsnarTan
erTad-1, 5, 50.
venaSi ineqciisaTvis:
1 flakoni mSrali fxvniliT, romelic Sesabamisad Seicavs 0.25g, 0.5g an 1g
ceftriaqsons da 1 ampula 5ml an 10ml saineqcio wyalTan erTad-1, 5, 50.
venaSi ineqciisaTvis:
1 flakoni mSrali fxvniliT, romelic Sesabamisad Seicavs 2g
ceftriaqsons-1, 5, 50.
kunTebSi, venaSi saineqcio an sainfuzio xsnaris SefuTva:
1 flakoni mSrali fxvniliT, romelic Sesabamisad Seicavs 1g
ceftriaqsons-50, 100, 143.-jgufuri SefuTva
mwarmoebeli:
“F. HOFFMANN-La ROCHE LTD”
Sveicaria
farmakologiuri komitetis
Tavmjdomare n. gongaZe