damxmare nivTierebebi:

gpc.ge

damxmare nivTierebebi:

vamtkicebsaqarTvelos janmrTelobisa dasocialuri dacvis ministri----------------------------- g. wereTeli“-----” ----------------------- 2004 weligamoyenebis instruqciageneriuli dasaxeleba:loperamidelopediumi(LOPEDIUM)Semadgenloba da gamoSvebis formakafsulebi: SefuTvaSi 10 da 20 c.1 kafs.loperamidis hidroqloridi. . . . . . 2 mgdamxmare nivTierebebi:Jelatini, laqtoza, magniumis stearati, simindis saxamebeli, talki.kliniko-farmakologiuri jgufidiareis sawinaaRmdego saSualebafarmakodinamikapreparati aqveiTebs nawlavebis gluvi kunTebis tonuss da peristaltikas,nawlavebSi lokalizebul opioidur receptorebtan SekavSirebis gamo, romelTamimarT (gansakuTrebiT miu-receptorebis). mas gaaCnia maRali afiniteti. igi agreTvezrdis analuri sfinqteris tonuss, amcirebs siTxisa da eleqtrolitebis sekreciasnawlavebSi. efeqti vlindeba serafad da grZeldeba 4-6 sT-is ganmavlobaSi.loperdiumi ar moqmedebs nawlavis mikrofloraze.farmakokinetikalopediumis peroralurad miRebisas kuW-nawlavis traqtidan absorbirdeba miRebulidozis 65%. misi bioSeRwevadoba Seadgens 17%-s. koncentraciis piki (C max )aRiniSneba 4 sT-Si. lopediumis plazmis cilebTan kavSiri Seadgens 95%-s. igi araRwevs hematoencefalur barierSi, amitom Tavis tvinSi identificirdeba mxolodmisi kvali. lopediumis mcire raodenoba gamoiyofa dedis rZeSi, miRebuli dozisproporciulad. RviZlSi igi eqvemdebareba ”pirveli gavlis” efeqts. Sewovilipreparatis 35% gamoiyofa naRveliT metabolitebis (ZiriTadad glukuronidebis)saxiT, romlebic nawlavebSi ganicdian hidrolizs mikrofloris zegavlenit.


preparatis danarCeni nawili gamoiyofa SardiT metabolitebis da 1% ucvleliloperamidis saxiT. lopediumis naxevradgamoyofis periodi Seadgens 10-12 sT-s.Cvenebebidiarea, romelic saSiSia sxvadasxva garTulebebis TvalsazrisiT; diarea nawlavebisanTebiTi daavadebebis da maTi funqciis darRvevisas, mwvave diarea eleqtrolitebismniSvnelovani dakargviT, pacientebSi ileostomiT. defekaciis regulirebisaTvis,simptomaturi mkurnaloba mozrdilebSi da bavSvebSi.dozirebis reJimimozrdilebSi da 12 wlis zeviT asakis bavSvebSi dasawyisSi iniSneba 2 kafsula(4mg), Semdgom igi 1 kafsula (2mg) yoveli defekaciis dros Txieri ganavlisSemTxvevaSi.preparatis maqsimaluri sadReRamiso doza ar unda aRematebodes 8 kafsulas (16mg).bavSvebSi 12 wlis asakis zemoT mwvave diareis dros iniSneba 1 kafsula (2mg).maqsimaluri sadReRamiso doza ar unda aRematebodes 4 kafsulas (8mg).12 wlamde asakis bavSvebSi loperamidis miReba ar aris mizanSewonili preparatSiaqtiuri nivTierebis maRali Semcvelobis gamo.gverdiTi movlenebiiSviaTad SesaZlebelia Tavis tkivili, gadaRliloba, Tavbrusxveva, muclis areSispazmebi, gulisreva, piris simSrale da kanze gamonayari.erTeul SemTxvevebSi adgili aqvs nawlavis sanaTuris daxSobas da toqsikurmegakolons.ukuCvenebebimomatebuli mgrZnobeloba lopediumis mimarT.nawlavebis peristaltikis daTrgunva, maRali temperaturiT da sisxlianigamonadeniT mimdinare diarea, antibiotikebis miRebiT gamowveuli diarea. qronikulidiarea, mwvave koliti, orsuloba da laqtacia.2 wlamde asakis bavSvebSi loperamidis gamoyeneba nebadarTuli ar aris.2-12 wlis asakSi preparatis miReba nebadarTulia mxolos eqimTan konsultaciiT.gansakuTrebuli miTiTebebiRviZlis funqciis darRveviT Sepyrobil pacientebSi, organizmSi didi raodenobiTlopediumis dagrovebis saSiSroebis gamo sifrTxilea saWiro.lopediumis miReba 2 dReze meti xnis ganmavlobaSi nebadarTuli ar aris. imSemTxvevaSi, rodesac mwvave diareis dros 2 dRis Semdeg ar aRiniSneba avadmyofismdgomareobis gaumjobeseba saWiroa eqimTan konsultacia.sifrTxilea saWiro lopediumis miRebisas kronis daavadebis, xandazmul pacientebSi.lopediumi ar iwvevs SeCvevas, eiforias da sunTqvis centris datrgunvas. igi arcvlis nawlavis mikrofloras. RrviZlSi “pirveli gavlis” efeqtis gamo TerapiuldozebSi. igi avlens sistemur moqmedebas. aseve ar moqmedebs avtotransportis damanqana danadgarebis martvis unarze.orsuloba da laqtaciaorsulobis dros preparatis gamoyenebis Sesaxeb monacemebis ar arsebobis gamo, amdros loperamidis daniSvna ar aris nebadarTuli.


loperamidi gadadis dedis rZeSi, amitom misi gamoyeneba laqtaciis ar arismizanSewonili.Warbi dozirebaiSviaTad viTardeba ftozi, kunTebis hipertonusi, Zilianoba, bradipnoe.mkurnaloba:antidotis saxiT SehyavT naloqsoni. saWiroa monitoringi 48 sT.sxva wamlebTan urTierTqmedebaar aris dadgenili.Senaxvis pirobebi da vadapreparati inaxeba oTaxis temperaturaze, mSral, sinaTlisagan da bavSvebisagandacul adgilas.vargisianobis vada – 5 welimwarmoebeli firma:HEXAL (Germany)farmakologiuri komitetisTavmjdomaren. gongaZe

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