preparatis gamoyenebis instruqcia ciprinoli® sainfuzio xsnari ...

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preparatis gamoyenebis instruqcia ciprinoli® sainfuzio xsnari ...

preparatis gamoyenebis instruqciaciprinoli ®sainfuzio xsnari (koncentrati) 100 mg/10 ml,sainfuzio xsnari 100 mg/50 ml,sainfuzio xsnari 200 mg/100 mlCiprinol ®ciprofloqsacini, CiprofloxacinumSemadgenloba10 ml (1 ampula) koncentrati Seicavs 100 mg ciprofloqsacins laqtatissaxiT.1 ml koncentrati Seicavs 10 mg ciprofloqsacins laqtatis saxiT.damxmare nivTierebebi: rZemJava, marilmJava, dinatriumis edetati, saineqciowyali.50 ml (1 flakoni) koncentrati Seicavs 100 mg ciprofloqsacins laqtatissaxiT.100 ml (1 flakoni) koncentrati Seicavs 200 mg ciprofloqsacins laqtatissaxiT.1 ml xsnari Seicavs 2 mg ciprofloqsacins laqtatis saxiT.damxmare nivTierebebi: natriumis laqtati, natriumis qloridi, marilmJava,saineqcio wyali.Tvisebebi da moqmedebaciprinoli – erTerTi yvelaze efeqturi sinTetikuri qimioTerapiulisaSualebaa, romelic ganekuTvneba mikrobebis sawinaaRmdego farTo speqtrismoqmedebis mqone qinolonebis jgufs. baqteriuli girazas A suberTeulisinhibirebiT, ciprinoli anelebs baqteriuli dnm-s replikacias, romelicaucilebelia cilebis sinTezisaTvis. preparats gaaCnia baqtericidulimoqmedeba umetesi gram-dadebiTi da gram-uaryofiTi mikroorganizmebis mimarTiseve, rogorc sxva antibiotikebis moqmedebaze mdgradi mikroorganizmebismimarT. ciprofloqsacinis in vitro mimarT mgrZnobiareni arian Semdegi gramuaryofiTimikroorganizmebi: enterobaqteriebi (E. coli, Shigella spp., Salmonella spp.,Citrobacter, Klebsiella spp., Enterobacter spp., Proteus Providencia spp., Morganella morganii, Vibrospp., Yersinia spp.); sxva gram-uaryofiTi mikroorganizmebi (Aeromonas spp.,Plesiomonas shigeloides, Pseudomonas Aeruginosa, Neisseia spp., Moraxella (Branhamella)catarrhlis); zogierTi Sidaujreduli gamaRizianebeli (Legionella pneumophila, Brucellaspp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacteriumkansasii, Mycobacterium aviumintracellulare). gram-dadebiT baqteriebs Sorisdamtkicebulia mgrZnobeloba in vitro Semdegi baqteriebis mimarT: Staphylococcusspp. (S. aureus, S. haemolyticus, S. hominis da S. saprophyticus) da Streptococcus spp. (S. pyogenesda S. agalactiae). meTicilinis mimarT mdgradi stafilokokTa umetesoba, mdgradniarian ciprofloqsacinis mimarTac.baqteriebis Streptococcusa pneumoniae da Streptococcusa faecalisa mgrZnobelobazomieria.Corynebacterium spp., Bacteroides fragillis, Pseudomonas ceracia da maltophilia, Ureaplasmaurealyticum, Clostridiumdifficile, Nocardia asteroides, Streptococcus faecium da Treponema pallidumjgufis baqteriebi ciprofloqsacinis mimarT mdgradni arian.infuziis dawyebidan 60 wuTSi 200 mg da 400 mg dozirebisas preparatiskoncentracia SratSi Seadgens 2.1 μg/ml an 4.6 μg/ml. preparatis koncentraciaSardSi miRebidan pirveli ori saaTis ganmavlobaSi TiTqmis 100-jer metia,vidre SratSi. naxevargamoyofis periodi TiTqmis 3-5 saaTs Seadgens. dozis


fizikur datvirTvas. mkurnalobis periodSi rekomendebuli ar arisalkoholis miReba.orsuloba da laqtaciaciprinolis gamoyeneba orsulobis periodSi daiSveba mxolod maSin, rodesacmosalodneli sargebeli dedisaTvis aRemateba potenciur risks nayofisaTvis.ciprinoli aRwevs dedis rZeSi, amitom laqtaciis periodSi misi gamoyenebarekomendebuli ar aris. Tu ciprinoliT mkurnaloba aucilebelia, ZuZuTikveba unda Sewydes.zegavlena fsiqofizikur unarebzestandartuli dozirebiT ciprinols SeuZlia Seamciros swrafi reaqciisunari, gansakuTrebiT im SemTxvevaSi, Tu avadmyofi mas alkoholTan erTadiRebs. eqimma da farmacevtma amis Sesaxeb avadmyofs unda acnobon, Tumkurnalobis dros avadmyofi avtotransports marTavs an dazgebze muSaobs.urTierTqmedeba sxva wamlebTanciprofloqsacinisa da Teofilinis an kofeinis erTad gamoyenebam SeiZlebagamoiwvios plazmaSi Teofilinis an kofeinis koncentraciis momateba da maTigamoyofis drois gaxangrZliveba. ciprinolisa da ciklosporinis erTadmiReba ciklosporinis nefrotoqsikurobas zrdis. rekomendebulia SratSiTeofilinisa da ciklosporinis koncentraciis xSiri kontrolis Catareba.ciprinolisa da antikoagulantebis kombinirebisas SesaZloa gaxangrZlivdessisxldenis dro, ris Sedegadac aucilebelia proTrombinuli droiskontroli.dozireba da gamoyenebis wesivenaSi Sesayvanad yvela kargia xanmokle infuziis gamoyeneba (igi 60 wuTiunda grZeldebodes). rekomendebulia Semdegi dozebi: zeda saSarde gzebisgaurTulebeli infeqciebi: 200 mg dReSi orjer.zeda saSarde gzebis garTulebeli infeqciebi: 400 mg dReSi orjer.mZime infeqciebi (pnevmonia, osteomieliti): 400 mg dReSi orjer.sxva infeqciebi: 200-400 mg dReSi orjer.Zalian mZime infeqciebisa da gamaRizianeblis susti mgrZnobelobis dros(mag., infeqcia, gamowveuli P. aeruginosa fibrozuli kistozis dros)sadReRamiso dozis gazrda SeiZleba 400 mg-mde samjer dReSi venaSi. mwvavegonoreis mkurnalobis dros sakmarisia 100 mg-s erTjeradad venaSi Seyvana.xandazmul pacientebSi dozis Semcireba SeiZleba kreatininis klirensis,daavadebis saxobisa da simZimis mixedviT.qirurgiuli Carevebis dros infeqciebis prevenciisaTvis iniSneba 200-400 mgvenaSi 1/2-1 saaTiT adre operaciamde. operaciis 4 saaTze met xansgagrZelebisas doza meordeba.avadmyofebSi, romlebsac Tirkmelebis fuqnciis mZime darRvevebi awuxebT, 20ml/wT-ze naklebi kreatininis klirensiT (0.33 ml/w; kreatininis koncentraciaSratSi 400 μmoli/l-ze meti) iniSneba an Cveulebrivi erTjeradi sadReRamisodoza an dozis naxevari dReSi orjer. avadmyofebSi Tirkmlis terminaluriukmarisobiT, romlebic mudmivad qronikul hemodializze imyofebian,maqsimaluri doza Seadgens 500 mg-s dReSi. hemodializis dros preparatisumniSvnelo danakargis Sedegad, misi Catarebis Semdeg ciprinolisanazRaureba saWiro ar aris.ambulatorul peritonul hemodializze myof peritonitiT daavadebulavadmyofebSi rekomendebulia 50 mg/l ciprofloqsacinis dializatis muclisRruSi dReSi oTxjer Seyvana.mkurnalobis xangrZlivoba damokidebulia daavadebis simZimeze, klinikuri dabaqteriologiuri analizebis simZimeze. infuziiT sawyisi mkurnalobis


gagrZeleba tabletebiT TerapiiT SeiZleba. mkurnaloba grZeldeba:Cveulebriv 3-14 dRe, xolo qronikuli prostatitisa da osteomielitis dros– 4-6 kvira da meti.sainfuzio xsnaris momzadebagamoyenebis win sainfuzio koncentrati aucileblad unda gazavdes Sesabamisisainfuzio siTxiT: fiziologiuri xsnariT, ringeris an hartmanis xsnariT, 5%an 10%-ani glikozaTi, fruqtozas 10% xsnariT da glukozas 5% xsnariT0.225% NaCl an 0.45% NaCl (minimaluri moculoba 50 ml).ar SeiZleba ciprinolis Sereva sainfuzio xsnarebTan da ineqciebTan,romlebsac pH 3-4 fizikuri da qimiuri arastabiluroba gaaCniaT.Warbi dozaWarbi dozis Sedegi SeiZleba iyos Rebineba, gulisreva, diarea, Tavis tkivilida gulyra, ufro mZime SemTxvevebSi SfoTva, aRelveba, halucinaciebi dakrunCcvebi. dozebi unda Semcirdes an droebiT Sewydes infuzia. mkurnalobasimptomaturia. mniSvnelovania kargi hidratacia. mowamvlisas hemodializiaraefeqturia.gverdiTi movlenebigverdiTi movlenebi yvelaze xSirad saWmlis momnelebel traqtSi viTardebada Rebinebis, gulisrevis, meteorizmis, mucelSi tkivilis, umadobis, diareissaxiT vlindeba. Zlieri da xangrZlivi diareis an fsevdomembranuli kolitisdros, aucilebelia Terapiis Sewyveta.sxva gverdiTi movlenebi centralur nervul sistemaSi vlindeba(Tavbrusxveva, Tavis tkivili, daRliloba, SfoTva, naRvlianobis SegrZneba,krunCcvebi, qalaSida wnevis momateba, toqsikuri fsiqozi, halucinaciebi dasensoruli darRvevebi, maT Soris mxedvelobis darRvevebi, diplopia,arasasiamovno gemo, Suili yurebSi). alergiuli reaqciebi: kanis (egzaTema,eriTema, qavili), cxeleba, saxis SeSupeba, iSviaTia mgrZnobeloba sinaTlismimarT da anafilaqsiuri reaqcia, eozinofilia.kardiovaskularuli reaqciebi: sisxlis wnevis daweva, hipertenzia,paroqsizmuli taqikardia.sxva reaqciebi: saxsrebisa da kunTebis tkivili, lokaluri reaqciebi ineqciisdgilas, kristaluria.zegavlena laboratoriul parametrebze: upirvelesad avadmyofebSi RviZlisfunqciis darRvevebiT SesaZloa droebiT gaezardoT transaminazebisa datute fosfotazis aqtivoba; aseve SeiZleba tranzitulad gaizardosSardovanas, kreatininisa da bilirubinis koncentracia SratSi.Zalian iSviaTad da rogorc wesi sxva mavne faqtorebTan kombinaciaSiftorqinolonebs SeuZliaT gamoiwvios myesis tendiniti da gawyveta.aucilebelia mkurnalobis Sewyveta, Tu mZime gverdiTi efeqtebi ganviTarda(gansakuTrebiT hipermgrZnobelobis reaqciebi, fsevdomembranuli koliti,nervuli sistemis darRvevebi, halucinaciebi da tkivili myesebis areSi).Senaxvis pirobebiinaxeba mSral, bavSvebisaTvis miuwvdomel adgilas, araumetes 25 0 Ctemperaturaze. preparatis gayinva ar SeiZleba.vargisianobis vadapreparatis gamoyeneba SefuTvaze miTiTebuli vargisianobis vadis gasvlisSemdeg ar SeiZleba.gacemis pirobebisainfuzio koncentrati: gamoyeneba nebadarTulia mxolod saavadmyofoebSi.gamonaklis SemTxvevebSi, saavadmyofodan gaweris Semdeg mkurnalobisgagrZelebisas preparati gaicema mxolod receptiT.


venaSi Sesayvani xsnari 100 mg/50 ml da 200 mg/100 ml: gamoyeneba nebadarTuliamxolod saavadmyofoebSi.SefuTva.sainfuzio xsnari (koncentrati), 10 ml-ani 5 ampula, 100 mg/50 ml.sainfuzio xsnari, 100 ml/ani 1 flakoni, 200 mg/100 ml.mwarmoebeli. krka, d.d., novo mesto slovenia.

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