saqarTvelos Sromis, janmrTelobisa da socialuri dacvis ministri
saqarTvelos Sromis, janmrTelobisa da socialuri dacvis ministri
saqarTvelos Sromis, janmrTelobisa da socialuri dacvis ministri
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“vamtkiceb”<strong>saqarTvelos</strong> <strong>Sromis</strong>, <strong>janmrTelobisa</strong> <strong>da</strong><strong>socialuri</strong> <strong>da</strong>cvis <strong>ministri</strong>----------------------------- a. gamyreliZe“--------“ _______________ 2003w.diflukanigamoyenebis instruqciaÀÌÏÚÄÍÄÁÉÓ ÉÍÓÔÒÖØÝÉÀDIFLUCANgeneriuli <strong>da</strong>saxeleba:FluconazoleSemadgenloba:kafsulebiaqtiuri nivTierebaflukonazoli-50mg, 100mg, 150mg <strong>da</strong> 200mg<strong>da</strong>mxmare nivTierebebi: laqtoza, simindis saxamebeli, siliciumiskoloiduri dioqsidi, natriumis stearati <strong>da</strong> natriumis lauril sulfati.fxvnili <strong>da</strong>salevi suspenziis mosamzadebla<strong>da</strong>qtiuri nivTierebaflukonazoli<strong>da</strong>mxmare nivTierebebi:saqaroza, siliciumis koloiduri orJangi, titanis dioqsidi, qsantanisfisi, natriumis citrati, limonis mJava, natriumis benzoati <strong>da</strong>forToxlis naturaluri Semavsebeli.diflukanis sainfuzio xsnariaqtiuri nivTierebaflukonazoli<strong>da</strong>mxmare nivTierebanatriumis qloridiforma:kafsulebi 50mg; 100mg; 150mg, 200mgfxvnili <strong>da</strong>salevi suspenziis mosamzadebladsainfuzio xsnarifarmakoTerapiuli jgufi:sokos sawinaaRmdego saSualeba
Cveneba:diflukans iyeneben sokovani infeqciebis samkurnalod. sokovani infeqciebismetad xSir gamomwvevs warmoadgens safuaris msgavsi kandi<strong>da</strong>s jgufis soko.preparati iniSneba eqimis rekomen<strong>da</strong>ciiT Semdegi infeqciebis samkurnalod:-kandidozuri stomatiti an piris Rrusa <strong>da</strong> xorxis rZiana (lorwovanigarsebis infeqcia). rZianas ZiriTa<strong>da</strong>d iwvevs kandi<strong>da</strong>s jgufis soko.-filtvebis, Sardgamomyofi sistemis <strong>da</strong> kanis kandidozuri infeqciebi.-piris Rrus kandidozuri infeqciebi kbilebis proTezis mqone pirebSi(piris Rrus lorwovani garsebis wylulebi, rac <strong>da</strong>kavSirebulia kbilebisproTezis tarebasTan).-kanis infeqciebi, mag, terfebis mikozebi, dermatomikozebi, frCxilisinfeqciebi.-kandi<strong>da</strong>s jgufis sokoTi gamowveuli Sinagani organoebis sokovani(sistemuri) infeqciebi, mag, sisxlis (kandidemia), saSarde gzebis(kandiduria) an sxva organoebis infeqciebi.-infeqciebi <strong>da</strong>qveiTebuli imunuri sistemis mqone avadmyofebSi intensiurTerapiul ganyofilebebSi.-kriptokokozi, maT Soris kriptokokuri meningiti <strong>da</strong> sxva lokalizaciis(filtvi, kani <strong>da</strong> sxva) kriptokokuri infeqciebi.diflukanis gamoyeneba SesaZlebelia agreTve kriptokokiT gamowveulimeoradi sokovani infeqciebis profilaqtikis mizniT.-sasqeso organoebis kandidozuri infeqciebi, mag, vaginaluri kandidozi,agreTve vaginaluri kandidozis recidivebis Sesamcireblad (3 <strong>da</strong> metiepizodi weliwadSi).-kandidozuri balaniti (asos Tavis anTeba <strong>da</strong>\an CuCis anTeba).preparatis gamoyeneba SesaZlebelia meoradi sokovani infeqciebisprofilaqtikis mizniT imunuri sistemis <strong>da</strong>avadebul avadmyofebSi.diflukans iyeneben agreTve iseTi iSviaTi sokovani infeqciebissamkurnalod, rogoricaa: kokcidiomikozi, parakokcidiomikozi,sporotriqozi <strong>da</strong> histoplazmozi.winaaRmdegCveneba:momatebuli mgrZnobeloba preparatis an misi Semadgeneli komponentebismimarT.alergiuli reaqciebi, qavilis, kanis hiperemiis an sunTqvis gaZnelebisCaTvliT.diflukanis kombinacia terfenadinTan <strong>da</strong> cizapridTan neba<strong>da</strong>rTuli araris.sifrTxile:preparati sifrTxiliT iniSneba iseTi mdgomareobebis dros rogoricaa:arsebuli an <strong>da</strong>gegmili orsuloba;laqtaciis periodi;Tirkmelebis <strong>da</strong>avadebebi.
gverdiTi movlenebi:diflukani ZiriTa<strong>da</strong>d xasiaTdeba kargi amtanianobiT, magram zogjerSesaZlebelia Semdegi gverdiTi movlenebi:gulisreva, Rebineba, diarea, meteorizmi, gamonayari kanze.im SemTxvevaSi, rodesac ze<strong>da</strong>piruli sokovani infeqciis mkurnalobisprocesSi warmoiqmneba gamonayari, romelic <strong>da</strong>kavSirebulia diflukanismiRebasTan, saWiroa preparatiT mkurnalobis Sewyveta.invaziuri\sistemuri infeqciebis mkurnalobis procesSi gamonayariswarmoqmnis SemTxvevaSi saWiroa eqimTan konsultacia. bulozurigamonayaris an multiformuli eriTemis warmoqmnis SemTxvevaSi saWiroapreparatiT mkurnalobis Sewyveta.zogjer SesaZlebelia tavis tkivili.iSviaT SemTxvevebSi flukonazolis gamoyenebisas aRiniSneba RviZlis mxrivtoqsiuri cvlilebebi, romelic, rogorc wesi, aReniSnebaT mZime sokovaniinfeqciebiT <strong>da</strong>avadebul avadmyofebs. amitom RviZlis <strong>da</strong>zianebis klinikurigamovlinebisTanave saWiroa Sewydes preparatiT mkurnaloba.diflukanis miRebisas iSviaTad SesaZlebelia agreTve cvlilebebi sisxlis,RviZlis funqciis, Sardis an bioqimiuri maCveneblebis mxriv. aRniSnulicvlilebebis SemTxvevaSi saWiroa gansakuTrebuli samedicino kontroli.flukonazoliT mkurnalobisas iSviaT SemTxvevebSi viTardeba kanis mxriveqsfoliatiuri reaqciebi.SidsiT <strong>da</strong>avadebul avadmyofebSi mniSvnelovnad momatebulia kanis mZimereaqciebis ganviTarebis riski sxva<strong>da</strong>sxva preparatebze.iSviaTad zogierT avadmyofebs aReniSnebaT alergiuli reaqciebidiflukanis mimarT:moxrCobis uecari SegrZneba, sunTqvis gaZneleba an moWeriTi xasiaTistkivili gulmkerdis areSi;quTuToebis, saxis <strong>da</strong> tuCebis SeSupeba;kanze gamonayari an qaviliT mimdinare wiTeli laqebi;mTeli sxeulis qavili.aRniSnuli gverdiTi reaqciebis SemTxvevaSi saWiroa eqimTan konsultacia.urTierTqmedeba sxva preparatebTan:flukonazoli gansakuTrebuli sifrTxiliT iniSneba iseT preparatebTankombinaciaSi rogoricaa:varfarini an kumarinis tipis antikoagulantebi, peroralurihipoglikemiuri saSualebebi, rogoricaa qlorpropamidi, glibenklamidi,glipizidi an tolbutamidi, hidroqlorTiazidi, fenitoini, rifampicini <strong>da</strong>rifabutini, ciklosporini <strong>da</strong> takrolimusi, Teofilini, terfenadini <strong>da</strong>asTemizoli, cizapridi, zidovudini.miRebis wesi <strong>da</strong> dozireba:diflukanis kafsulebi <strong>da</strong> <strong>da</strong>salevi suspenziis mosamzadebeli fzvniligamoiyeneba mxolod SigniT misaRebad. kafsulebs iReben mcire raodenobiswyalTan erTad.
<strong>da</strong>salevi suspenziis mosamzadebel fxvniliT savse flakons anjRreven <strong>da</strong>umateben 24ml wyals. flakonis SenjRreva warmoebs uSualod gamoyenebiswin. kafsulebis <strong>da</strong> suspenziis miReba xdeba erTsa <strong>da</strong> imave dros.preparatis miReba SesaZlebelia rogorc sakvebis miRebis dros, agreTvemisi miRebis Soris intervalSi.flukonazolis sainfuzio xsnari SehyavT venaSi ara umetes 10ml\wT-SisiCqariT.im avadmyofebs, romelTac ezRudebaT natriumis miReba, saWiroa maTiinformireba diflukanis saineqcio xsnarSi arsebuli 0.9% natriumisqloridis arsebobis Sesaxeb.mozrdilebSi-piris Rrus lorwovani garsis <strong>da</strong> xorxis kandidozuri infeqciebi-50-100mg erTxel dReRameSi 7-14 dRis ganmavlobaSi <strong>da</strong> meti.-piris Rrus lorwovani garsis infeqciebi kbilebis proTezis mqoneavadmyofebSi-50mg erTxel dReRameSi 14 dRis ganmavlobaSi (proTezisdezinfeqciis SemTxvevaSi).-saylapavis kandidozuri infeqciebi, filtvebis arainvaziuri infeqciebi,Sardgamomyofi sistemis infeqciebi, agreTve kanisa <strong>da</strong> lorwovaniskandidoziT gamowveuli mdgomareoba-50-100mg erTxel dReRameSi 14-30dRis ganmavlobaSi.-SidsiT <strong>da</strong>avadebul avadmyofebSi piris Rrusa <strong>da</strong> xorxis ganmeorebiTikandidozuri infeqciebis profilaqtika- 150mg kviraSi erTxel.-sasqeso organoebis kandidozuri infeqciebis mkurnaloba-150mgerTjera<strong>da</strong>d.-vaginaluri kandidozis recidivebiT Sepyrobili qalebis mkurnaloba (3 <strong>da</strong>meti epizodi weliwadSi)-150mg TveSi erTxel 4-12 Tvis ganmavlobaSi anmeti aucileblobis SemTxvevaSi.-kanis mikozuri infeqciebi-50mg erTxel dReRameSi 2-4 kviris ganmavlobaSi.terfis dermatomikozebis dros SesaZlebelia mkurnalobis gaxangrZliveba(6kviramde).-mravalferovani liqenis dros rekomendebul dozas Seadgens 300mg 1-xelkviraSi 2 kviris ganmavlobaSi. zogierT avadmyofebSi SesaZlebelia 300mgpreparatis mesamedis gamoyeneba kviraSi, maSin rodesac sxva avadmyofebSisakmarisia 300-400mg diflukanis erTjera<strong>da</strong>d miReba. mkurnalobisalternatiul sqemas warmoadgens preparatis 50mg 1-xel dReRameSi 2-4kviris ganmavlobaSi.-oniqomikozis dros-150mg kviraSi erTxel. mkurnaloba grZeldebaSesabamisad 3-6 Tve (xelebze) <strong>da</strong> 6-12 Tve (fexebze).-Sinagani organoebis kandidozuri infeqciebi-400mg pirvel dRes, Semdgom200-400mg erTxel dReRameSi. sicocxlisaTvis saSiSi kandidozuriinfeqciebis dros SesaZlebelia preparatis dozis gazr<strong>da</strong> 800mg-mdedReRameSi.-ganmeorebiTi kandidozuri infeqciebis profilaqtika-50-400mg erTxeldReRameSi infeqciis ganviTarebis momatebuli riskis periodSi.-Sinagani organoebis kriptokokuli infeqciebi-400mg pirvel dRes, Semdgom200-400mg erTxel dReSi 6-8 kviris ganmavlobaSi <strong>da</strong> meti. sicocxlisaTvis
saSiSi kriptokokuli infeqciis dros SesaZlebelia preparatis dozisgazr<strong>da</strong> 800mg-mde dReRameSi.-SidsiT <strong>da</strong>avadebul avadmyofebSi kriptokokuli meningitis recidivisprofilaqtika-200mg erTxel dReRameSi ganusazRvreli xangrZlivi droisganmavlobaSi.-kokcidiomikozis, parakokcidiomikozis, spirotriqozis <strong>da</strong> histoplazmozisdros-200-400mg erTxel dReRameSi 2 wlis ganmavlobaSi <strong>da</strong> meti.bavSvebSi 4 kviri<strong>da</strong>n 15 wlis asakamde:-lorwovani garsebis kandidozuri infeqciebi-3mg\kg wonaze erTxeldReRameSi pirvel dRes, SemdgomSi 6mg\kg wonaze dReRameSi.-Sinagani organoebis kandidozuri an kriptokokuli infeqciebi-6-12mg\kgwonaze erTxel dReRameSi.-sokovani infeqciebis profilaqtika maTi ganviTarebis momatebuli riskisperiodSi-3-12mg\kg wonaze erTxel dReRameSi.axalSobilebs <strong>da</strong>badebi<strong>da</strong>n pirveli 2 kviris ganmavlobaSi preparatieniSnebaT igive dozebSi (mg\kg wonaze), rogorc Se<strong>da</strong>rebiT mozrdili asakisbavSvebs, magram 72sT-iani intervaliT, xolo 2-4 kviris axalSobilebSiigive doza SehyavT 48sT-iani intervaliT.xan<strong>da</strong>zmul avadmyofebs, romelTac ar aReniSnebaT Tirkmelebis funqciis<strong>da</strong>rRveva preparati eniSnebaT Cveulebrivi dozebiT.Tirkmelebis funqciis ukmarisobis mqone avadmyofebSi saWiroa doziskoreqcia.dozis ga<strong>da</strong>Warbeba:didi raodenobiT diflukanis erTjera<strong>da</strong>d miRebis SemTxvevaSi SesaZlebeliasxva<strong>da</strong>sxva gverdiTi movlenebis ganviTareba, romelTa koregireba warmoebseqimTan konsultaciiT Sesabamisi mkurnalobis gamoyenebiT samkurnalo<strong>da</strong>wesebulebaSi.Senaxvis pirobebi:ara umetes 30 0 C temperaturaze. gayinva neba<strong>da</strong>rTuli ar aris.bavSvebisagan <strong>da</strong>cul adgilas.Senaxvis va<strong>da</strong>:preparatis miReba vadis gasvlis Semdeg neba<strong>da</strong>rTuli ar aris.SefuTva:N7 50mg, 100mg <strong>da</strong> 200mg kafsulebi blisterSi an N1 150mg kafsulablisterSi.fxvnili <strong>da</strong>salevi suspenziis mosamzadeblad flakonebSi 50mg\5ml-Si an200mg\5ml-Si.50ml sainfuzio xsnari gamWvirvale minis flakonebSi. xsnari Seicavsnatriumis qlorids.
mwarmoebeli:“PFIZER”safrangeTifarmakologiuri komitetisTavmjdomaren. gongaZe
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